Multi-target region ion and photon simultaneous radiotherapy system

Abstract

The present application belongs to the field of tumor treatment, and particularly relates to a multi-target ion and photon synchronous radiotherapy system, which comprises a rotating seat for driving the human body to rotate, an ion therapy module and a photon therapy module being arranged around the rotating seat; a release end of the ion therapy module is arranged towards the rotating seat, and the ion therapy module is used for outputting an ion beam to a drug-resistant tumor target area; meanwhile, a release end of the photon therapy module is arranged towards the rotating seat, and the photon therapy module is used for outputting a photon beam to a sensitive tumor target area; the rotating seat, the photon therapy module and the ion therapy module are respectively signal connected to a controller, and a treatment scheme planning module is signal connected to the controller. The present application provides a multi-target ion and photon synchronous radiotherapy system, and aims to solve the problem that the drug-resistant tumor area and the sensitive tumor area cannot be treated by the conventional means.

Description

TECHNICAL FIELD

[0001] The application belongs to the field of tumor treatment, and particularly relates to a multi-target region ion and photon synchronous radiotherapy system. BACKGROUND

[0002] As a malignant disease threatening human life and health worldwide, the incidence and mortality of tumors are on the rise. According to the statistics of the World Health Organization (WHO), there are more than 19 million new cases of malignant tumor patients every year, and the number of death cases accounts for 16% of the total number of deaths. Among them, lung cancer, breast cancer, colorectal cancer, liver cancer and other solid tumors, as well as leukemia, lymphoma and other hematological tumors are high-incidence types. With the aggravation of population aging, changes in lifestyle (such as high-fat diet, sedentary, smoking) and environmental pollution exposure, the disease spectrum of tumor is gradually complicated, and the proportion of cases of advanced, metastatic and multiple primary tumors is increasing year by year, which puts forward higher requirements for the precision, systematization and individualization of clinical treatment.

[0003] According to the applicant's clinical practice, it is found that by using a multi-point biomolecular imaging method, tumor cells in a tumor can be divided into a drug-resistant tumor cell region and a sensitive tumor cell region, and a plurality of sensitive and drug-resistant tumor target regions are constructed. The biological characteristics of drug-resistant tumor cells and sensitive tumor cells are different, and the inactivation of the drug-resistant tumor cell tumor target region is more difficult than that of the sensitive tumor cell tumor target region, which is also the main reason for the failure of current tumor treatment. The research background and related theories of this part can refer to some papers published by the present inventor in advance.

[0004] In the conventional tumor treatment process, the above two different biological characteristic tumor cell regions in an individual tumor cannot be distinguished and treated specifically, which leads to the problem of incomplete inactivation of drug-resistant tumor cells during tumor treatment, and further leads to the poor tumor treatment effect in the conventional method. SUMMARY

[0005] The present application provides a multi-target region ion and photon synchronous radiotherapy system, which aims to solve the problem that conventional tumor treatment cannot separately treat drug-resistant tumor regions and sensitive tumor regions.

[0006] In order to achieve the above object, the application provides a multi-target area ion and photon synchronous radiotherapy system, which comprises a rotating seat for driving the human body to rotate, an ion therapy module and a photon therapy module are arranged around the rotating seat; the release end of the ion therapy module is arranged towards the rotating seat, the ion therapy module is used for outputting an ion beam to a drug-resistant tumor target area, and the ion beam is used for inactivating the drug-resistant tumor target area; the release end of the photon therapy module is arranged towards the rotating seat, the photon therapy module is used for outputting a photon beam to a sensitive tumor target area, and the photon beam is used for inactivating the sensitive tumor target area; the rotating seat, the photon therapy module and the ion therapy module are signal connected to a controller, and a treatment plan module is signal connected to the controller.

[0007] The present application provides targeted treatment for the sensitive tumor target area through the photon therapy module, and targeted treatment for the drug-resistant tumor target area through the ion therapy module by maximizing the LET / RBE of the ion beam. The angle of the human body is adjusted through the rotating seat to ensure that the tumor of the human body can be completely covered and treated. The treatment plan module provides a cooperative control scheme for the photon beam, the ion beam, the rotating seat and the real-time image. The technical scheme of the present application provides accurate treatment for the sensitive tumor target area and the drug-resistant tumor target area, and has better treatment effect than the conventional treatment method in the prior art.

[0008] Preferably, in order to realize accurate treatment of the drug-resistant tumor target area, the scanning position, the dose rate and the output energy of the output end of the ion therapy module are adjustable, so as to adjust the LET / RBE and make the ion beam accurately act on the drug-resistant tumor target area. The scanning position, the dose rate and the output energy are adjusted, so that the ion beam can accurately act on the drug-resistant tumor target area, the accurate treatment of the drug-resistant tumor target area is realized by maximizing the LET / RBE, and the treatment effect is better.

[0009] Preferably, in order to realize accurate treatment of the sensitive tumor target area, the grating position and the dose rate of the output end of the photon therapy module are adjustable, so that the photon beam accurately acts on the sensitive tumor target area. The grating position and the dose rate are adjusted, so that the photon beam accurately acts on the sensitive tumor target area, and the accurate treatment of the sensitive tumor target area is realized.

[0010] Preferably, in order to monitor the position of the tumor target area and adjust the position of the seat, the present application further comprises an online real-time image module, which is arranged towards the rotating seat and is signal connected to the controller; the online real-time image module receives the control signal of the controller, monitors the position of the tumor target area in real time, returns the monitoring data to the controller, and the controller controls the working state change of the rotating seat, the ion therapy module and the photon therapy module.

[0011] The scheme obtains the three-dimensional image of the tumor through the online real-time image module, and the controller monitors the position of the tumor target area and adjusts the position of the seat according to the three-dimensional image, so as to facilitate accurate tumor treatment.

[0012] Preferably, since the human body is driven to rotate by the rotating seat, in order to obtain multi-angle images of the tumor target area during the rotation of the human body, the online real-time image module is provided as two, the two online real-time image modules are distributed at an included angle, and the two online real-time image modules cooperate to realize real-time monitoring of the position of the tumor target area.

[0013] The two online real-time image modules in the scheme can ensure multi-angle monitoring of the tumor target area during tumor treatment. At the same time, in order to reduce the mutual interference of the two online real-time image modules, the two online real-time image modules are distributed at an included angle.

[0014] Preferably, in order to obtain a three-dimensional image of the tumor target area, the online real-time image module includes an X-ray emitting device and a flat panel detector, the X-ray emitting device and the flat panel detector are oppositely arranged, and the rotating seat is located between the X-ray emitting device and the flat panel detector.

[0015] Preferably, the X-ray emitting device is a CT module unit or a CBCT module unit.

[0016] Preferably, in order to distinguish the drug-resistant tumor target area and the sensitive tumor target area, the scheme further includes a tumor multi-target area generation module, which is connected with the treatment plan module, and is used to obtain tumor target area information of tumor cells and send the tumor target area information to the treatment plan module.

[0017] In order to install the ion treatment module and the photon treatment module, the scheme further includes a treatment cabin, the rotating seat is arranged in the middle of the treatment cabin, and the photon treatment module and the ion treatment module are fixedly installed on the side wall of the treatment cabin.

[0018] Preferably, the tumor multi-target area generation module includes an organ image unit, a molecular image unit and a processor, the organ image unit is used to obtain the position information of the tumor in the human body, the molecular image unit is used to obtain the spatial density distribution information of the tumor cells, and the processor generates tumor target area information by the information obtained by the organ image unit and the molecular image unit and sends the tumor target area information to the treatment plan module.

[0019] Preferably, in order to make the partition of the drug-resistant tumor target area of the sensitive tumor target area more accurate, avoid errors, the molecular imaging unit obtains the spatial density distribution information of the tumor cells before treatment, and obtains the spatial density distribution information of the tumor cells after the predetermined dose of treatment.

[0020] The beneficial effects of the present application are that the present scheme sets up the cooperation of the photon therapy module and the ion therapy module, the ion therapy module is treated for the drug-resistant tumor target area, and the photon therapy module is treated for the sensitive tumor target area. At the same time, the photon therapy beam and the ion therapy beam can be accurately applied to the treatment target area position at different space angles at the same time through the rotating chair. Compared with the existing conventional tumor treatment means, the tumor treatment means of the present scheme is better. BRIEF DESCRIPTION OF DRAWINGS

[0021] Figure 1 It is a schematic diagram of a multi-target ion and photon synchronous radiotherapy system.

[0022] Figure 2 It is a reference diagram of the sensitive tumor target area and the drug-resistant tumor target area.

[0023] The reference signs include: a rotating chair 1, an ion therapy module 2, a photon therapy module 3, an online real-time imaging module 4, an X-ray emitting device 41, a flat panel detector 42, a spacer block 5, a controller 6, a treatment plan module 7, and a tumor multi-target generation module 8. DETAILED DESCRIPTION

[0024] In order to make the purpose, technical scheme and advantages of the embodiments more clear and understandable, the present application will be further described in detail below in combination with the drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and do not limit the present application.

[0025] Embodiment 1

[0026] This embodiment is basically as shown in the accompanying drawings Figure 1 A multi-target ion and photon synchronous radiotherapy system, including a rotating chair 1, an ion therapy module 2, a photon therapy module 3, an online real-time imaging module 4, a controller 6 and a treatment plan module 7.

[0027] The rotating chair 1 in this embodiment is fixedly arranged and can rotate 360 degrees around its axis. The human body can rotate uniformly 360 degrees on the rotating chair 1 following the rotating chair 1, and the rotating chair 1 can be appropriately raised and lowered to adjust the height and posture of the human body. The rotating chair 1 is configured with a motor as a power source to ensure that the rotating chair 1 can uniformly rotate the human body under the power of itself. The specific structure of the rotating chair 1 can adopt a seat with automatic rotation function and lifting function in the prior art.

[0028] The ion therapy module 2 of the embodiment is fixedly arranged towards the rotating chair 1, and can be fixedly installed on a wall of a treatment room, so that the ion therapy module 2 remains stable. When a human body is located on the rotating chair 1, the ion therapy module 2 outputs an ion beam to perform targeted treatment on a drug-resistant tumor target area in the human body. The ion therapy module 2 can be a proton therapy device or a heavy ion therapy device in the prior art. The ion therapy module 2 performs tumor treatment by releasing an ion beam, and can further perform precise treatment of maximizing LET / RBE of the drug-resistant tumor target area by adjusting a scanning position, a dose rate, and an output energy of the output ion beam.

[0029] The photon therapy module 3 of the embodiment is also arranged towards the rotating chair 1, and can be fixedly installed on a wall of a treatment room, so that the photon therapy module 3 remains stable. When a human body is located on the rotating chair 1, the photon therapy module 3 is used to perform targeted treatment on a sensitive tumor target area in the human body. The photon therapy module 3 is a photon therapy device in the prior art, which performs tumor radiotherapy by emitting a photon beam. The photon therapy device can also precisely act on the sensitive tumor target area by adjusting a dose rate of the output photon and adjusting a position of a grating, so as to perform precise treatment of the sensitive tumor target area.

[0030] In order to reduce radiation, the embodiment can be provided with an isolation block 5 on the wall facing the photon therapy module 3. The isolation block can be a lead block, which plays a role of isolation and blocking.

[0031] In order to reduce interference between the photon therapy module 3 and the ion therapy module 2, the photon therapy module 3 and the ion therapy module 2 are arranged at an included angle in the embodiment, and the included angle between the photon therapy module 3 and the ion therapy module 2 is preferably 90 degrees, at which the interference is smaller. Of course, in some embodiments, the included angle between the photon therapy module 3 and the ion therapy module 2 can also be other angles. However, the included angle between the photon therapy module 3 and the ion therapy module 2 cannot be 180 degrees, so as to avoid the photon therapy module 3 and the ion therapy module 2 from being opposite to each other.

[0032] In order to obtain the three-dimensional image of the tumor, so as to facilitate the monitoring of the tumor target position and the adjustment of the seat position, the online real-time image module 4 is arranged on the rotating seat 1. The online real-time image module 4 can be fixedly installed on the wall of the treatment room. The online real-time image module 4 comprises an X-ray emitting device 41 and a flat panel detector 42, and the X-ray emitting device 41 and the flat panel detector 42 are oppositely arranged, and the rotating seat 1 is located between the X-ray emitting device 41 and the flat panel detector 42. The X-ray emitting device 41 can be a CT module unit or a CBCT module unit. The three-dimensional image of the human body on the rotating seat 1 is obtained through the online real-time image module 4, so as to facilitate the monitoring of the tumor target position and the adjustment of the seat position.

[0033] In the embodiment, the online real-time image module 4 can be provided with one or two, but it is more preferred that the online real-time image module 4 is provided with two, and the three-dimensional image of the tumor is obtained by cooperation of the two online real-time image modules 4. The two online real-time image modules 4 are arranged at an included angle, and it is preferred that the included angle is 90 degrees. The two online real-time image modules 4 cannot be oppositely arranged.

[0034] In the embodiment, the online real-time image module 4, the rotating seat 1, the photon treatment module 3 and the ion treatment module 2 are signal-connected with the controller 6. The three-dimensional image of the tumor is fed back to the controller 6 by the online real-time image module 4, the controller 6 monitors the tumor target position and controls the adjustment of the seat state according to the three-dimensional image of the tumor; the rotating seat 1 can be uniformly rotated at different speeds under the control of the controller 6, and the height and posture of the rotating seat 1 can be adjusted; the photon treatment module 3 adjusts the dose rate of the output photons and adjusts the position of the grating under the control of the controller 6, so as to realize the accurate treatment of the sensitive tumor target; the ion treatment module 2 adjusts the dose rate of the output ions and adjusts the output energy under the control of the controller 6, so as to realize the accurate treatment of the drug-resistant tumor target. The controller 6 can be a medical equipment main controller used in the prior art, and only needs to increase the control and adjustment of the online real-time image.

[0035] Since the treatment control schemes required by different tumors are different, the treatment scheme planning module 7 is signal-connected with the controller 6 in the embodiment. The treatment scheme planning module 7 is used to determine the targeted treatment optimization control scheme according to different tumor states, and feed back the treatment control scheme to the controller 6. The controller 6 controls the working state of the rotating seat 1, the photon treatment module 3 and the ion treatment module 2 according to the treatment control scheme, so as to realize the targeted tumor treatment. The treatment scheme planning module 7 is specifically a computer, which formulates the targeted treatment control scheme and feeds back the treatment control scheme to the controller 6.

[0036] The following is further described in detail through a specific embodiment: Before the tumor is treated, the treatment plan module 7 formulates a corresponding treatment optimization control scheme for the tumor state, and feeds the corresponding treatment control scheme to the controller 6.

[0037] After the human body is located on the rotating seat 1, the rotating seat 1 drives the human body to rotate uniformly. During the rotation of the human body, the online real-time image module 4 collects the three-dimensional image of the tumor in the human body, and adjusts the posture of the human body and the posture of the rotating seat 1 according to the three-dimensional image of the tumor, to ensure the accurate treatment. After the posture of the human body and the posture of the rotating seat 1 are adjusted, the tumor treatment can be performed.

[0038] When the tumor is treated, the controller 6 controls the rotating seat 1 to drive the human body to rotate uniformly at a predetermined speed according to the obtained treatment control scheme; during the rotation of the human body, the controller 6 controls the ion treatment module 2 and the photon treatment module 3 to work cooperatively, to realize the targeted treatment of the sensitive tumor target area and the drug-resistant tumor target area in the tumor cells, and thus achieve a better treatment effect. During the treatment, the online real-time image module 4 monitors the tumor target area position at any time, and stops the treatment in time if an accident occurs.

[0039] Embodiment 2

[0040] This embodiment is improved on the basis of embodiment 1, as shown in Figure 1 In order to distinguish the sensitive tumor target area and the drug-resistant tumor target area in the tumor, the tumor multi-target area generation module 8 is signal-connected with the treatment plan module 7, the tumor multi-target area generation module 8 detects the tumor target area information of the tumor cells, and feeds the obtained information to the treatment plan module 7, and the treatment plan module 7 determines the treatment control scheme according to the obtained data.

[0041] The tumor multi-target area generation module 8 of this embodiment specifically includes an organ image unit, a molecular image unit and a processor. The organ image unit, the molecular image unit and the processor are signal-connected.

[0042] In the process of distinguishing the tumor target area, the position information of the tumor in the human body is obtained by the organ imaging device, and the spatial density distribution information of the tumor cells is obtained by the molecular imaging unit. The spatial density distribution information of the tumor cells is obtained indirectly by measuring the data such as tumor cell metabolic activity, fibrosis expression, and specific antibody. The images for obtaining the above data include tumor cell metabolism image, tumor fibrosis image, and tumor cell specific antibody image. When the molecular imaging unit obtains the spatial density distribution information, the spatial density distribution information of the tumor cells before treatment and the spatial density distribution information of the tumor cells after a predetermined dose of treatment (such as 2Gy of standard dose of radiotherapy) need to be obtained. Then, the organ imaging unit and the molecular imaging unit feed back the obtained information to the processor, and the processor processes the data by algorithm and model to generate a tumor drug sensitivity distribution map, which can be specifically referred to as shown in Figure 2 According to the tumor drug sensitivity distribution map and the spatial density distribution information of the tumor cells before treatment, the target area information of the drug-resistant tumor target area and the sensitive tumor target area is obtained.

[0043] Embodiment 3

[0044] This embodiment is improved on the basis of embodiment 1. In the scheme of embodiment 1, the rotating seat 1, the ion therapy module 2, the photon therapy module 3, and the online real-time imaging module 4 are installed on the wall of the treatment room. Obviously, due to the different positions of the wall, the installation state needs to be adjusted correspondingly in different environments, which is relatively cumbersome. In order to install the rotating seat 1, the photon therapy module 3, the ion therapy module 2, and the online real-time imaging module 4, a treatment cabin is separately provided as the installation basis. The treatment cabin can be a cylindrical cabin body, and the treatment cabin is provided with a cabin door for personnel to enter. The rotating seat 1 can be specifically installed at the middle position of the treatment cabin, and the online real-time imaging module 4, the photon therapy module 3, and the ion therapy module 2 are installed on the side wall of the treatment cabin, so that the online real-time imaging module 4, the photon therapy module 3, and the ion therapy module 2 remain stable and fixed in position.

[0045] The above is only an embodiment of the present application, and the specific structure and characteristics of the scheme are not described in detail. It should be pointed out that for those skilled in the art, without departing from the structure of the present application, a number of modifications and improvements can be made, which should also be considered as the protection scope of the present application, and these will not affect the effect and practicality of the patent. The protection scope claimed in this application should be subject to the content of its claims, and the specific implementation mode and the like recorded in the specification can be used to explain the content of the claims.

Claims

1. A multi-target area ion and photon synchronous radiotherapy system, characterized in that: It includes a rotating seat (1) for rotating the human body, and an ion therapy module (2) and a photon therapy module (3) are arranged around the rotating seat (1); The ion therapy module (2) has its release end facing the rotating seat (1). The ion therapy module (2) is used to output an ion beam to the drug-resistant tumor target area, and the ion beam inactivates the drug-resistant tumor target area. The photon therapy module (3) has its release end facing the rotating seat (1). The photon therapy module (3) is used to output a photon beam to the sensitive tumor target area, and the photon beam inactivates the sensitive tumor target area. The rotating seat (1), photon therapy module (3) and ion therapy module (2) are respectively signal-connected to the controller (6), and the controller (6) is signal-connected to the treatment plan planning module (7).

2. The multi-target ion and photon synchronous radiotherapy system according to claim 1, characterized in that: The scanning position, dose rate and output energy of the output end of the ion therapy module (2) are adjustable, so as to realize the adjustment of LET / RBE and enable the ion beam to act precisely on the drug-resistant tumor target area.

3. The multi-target ion and photon synchronous radiotherapy system according to claim 1, characterized in that: The position and dose rate of the grating at the output end of the photon therapy module (3) are adjustable, so that the photon beam can be precisely applied to the sensitive tumor target area.

4. The multi-target ion and photon synchronous radiotherapy system according to claim 1, characterized in that: It also includes an online real-time imaging module (4), which is arranged facing the rotating seat (1) and is signal-connected to the controller (6); The online real-time imaging module (4) receives control signals from the controller (6) and monitors the location of the tumor target area in real time; the online real-time imaging module (4) returns monitoring data to the controller (6), and the controller (6) controls the working status changes of the rotating seat (1), the ion therapy module (2) and the photon therapy module (3).

5. The multi-target ion and photon synchronous radiotherapy system according to claim 4, characterized in that: The online real-time imaging module (4) is configured as two, and the two online real-time imaging modules (4) are distributed at an angle to each other. The two online real-time imaging modules (4) work together to realize real-time monitoring of the tumor target area.

6. The multi-target ion and photon synchronous radiotherapy system according to claim 4, characterized in that: The online real-time imaging module (4) includes an X-ray emitting device (41) and a flat panel detector (42), which are arranged opposite to each other, and the rotating seat (1) is located between the X-ray emitting device (41) and the flat panel detector (42).

7. The multi-target ion and photon synchronous radiotherapy system according to claim 6, characterized in that: The X-ray emitting device (41) is a CT module unit or a CBCT module unit.

8. The multi-target ion and photon synchronous radiotherapy system according to claim 1, characterized in that: It also includes a tumor multi-target area generation module (8), which is connected to the treatment plan planning module (7). The tumor multi-target area generation module (8) is used to obtain tumor target area information of tumor cells and send the tumor target area information to the treatment plan planning module (7). And / or, it also includes a treatment chamber, wherein the rotating seat (1) is disposed in the middle of the treatment chamber, and the photon therapy module (3) and the ion therapy module (2) are fixedly installed on the side wall of the treatment chamber.

9. The multi-target ion and photon synchronous radiotherapy system according to claim 8, characterized in that: The tumor multi-target generation module (8) includes an organ imaging unit, a molecular imaging unit, and a processor. The organ imaging unit is used to acquire the location information of tumors in the human body, the molecular imaging unit is used to acquire the spatial density distribution information of tumor cells, and the processor generates tumor target information and sends it to the treatment plan module (7) based on the information acquired by the organ imaging unit and the molecular imaging unit.

10. The multi-target ion and photon synchronous radiotherapy system according to claim 9, characterized in that: The molecular imaging unit acquires the spatial density distribution information of tumor cells before treatment and the spatial density distribution information of tumor cells after treatment with a predetermined dose.

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