Skin care composition

Abstract

Described herein are personal care compositions, such as skin care exfoliating agents. According to certain aspects, there is provided a personal care composition comprising a retinoid, a beta-hydroxy acid, and / or a salt thereof; and terpenes are mixed; optionally, wherein the personal care composition is substantially free or free of resorcinol and / or hydroquinone.

Description

[0001] Cross-reference to related applications

[0002] This application claims the benefit of priority to U.S. Provisional Patent Application No. 63 / 489,017, filed March 8, 2023, entitled “Personal Care Compositions,” the contents of which are incorporated herein by reference in their entirety for all purposes. Background Technology

[0003] Skin care offers numerous benefits beyond restoring a youthful, radiant appearance. Every day, skin naturally sheds dead skin cells; however, due to aging, sun damage, or exposure to environmental pollutants, this natural shedding process can slow down and may even stop completely. Our skin becomes dull, dry, flaky, and wrinkled. By gently removing accumulated dead skin cells, you can restore firm, beautiful, and even-toned skin.

[0004] Many personal care products currently available to consumers primarily focus on improving skin health and / or appearance. For example, a variety of topical skin care products are available that address delaying, reducing, or even eliminating dry skin, wrinkles, and other histological changes typically associated with skin aging or environmental damage to human skin. Consequently, the sale of personal care products has become a booming industry in a youth-conscious society.

[0005] There is an increasing demand for personal care formulations with anti-aging, exfoliating, and brightening effects, which provide a healthy-looking glow while evening out skin tone. Summary of the Invention

[0006] This summary is intended only to provide a brief overview of some aspects of one or more embodiments of the present disclosure. Further areas of application of this disclosure will become apparent from the detailed descriptions provided below. This summary is not an exhaustive overview, nor is it intended to illustrate key or essential elements of the teachings, nor to define the scope of the disclosure. Rather, its purpose is merely to provide, in a concise form, one or more concepts as a prelude to the following detailed descriptions.

[0007] This invention relates to personal care compositions, and in some cases to skin care peels. According to one aspect, a personal care composition is provided comprising oleyl adapalate; a β-hydroxy acid and / or its salt; and a moisturizer. In some embodiments, the personal care composition may be in the form of a skin care peel.

[0008] According to another aspect, a personal care composition is provided comprising adapalene oleyl ester, α-hydroxy acid and / or its salt, and a saccharide isomer.

[0009] According to yet another aspect, a personal care composition is provided comprising adapalene oleyl ester, α-hydroxy acid and / or its salt, and lipoic acid and / or its salt.

[0010] The following provides a list of non-limiting example implementations.

[0011] According to embodiment 1, a personal care composition is provided, the personal care composition comprising:

[0012] oleyl adapalate;

[0013] β-hydroxy acids and / or their salts; and

[0014] Moisturizer.

[0015] According to embodiment 2, a personal care composition according to embodiment 1 is provided, wherein the personal care composition is a skin care exfoliant.

[0016] According to embodiment 3, a personal care composition according to embodiment 1 or embodiment 2 is provided, wherein the β-hydroxy acid and / or its salts include salicylic acid, β-hydroxybutyric acid, scopolamine, trosococcal acid, its salts, or a combination of two or more thereof.

[0017] According to embodiment 4, a personal care composition according to any of the foregoing embodiments is provided, wherein the β-hydroxy acid and / or its salts include salicylic acid, its salts, or combinations thereof.

[0018] According to embodiment 5, a personal care composition according to any of the foregoing embodiments is provided, wherein the β-hydroxy acid and / or its salt are present in an amount of about 5% to about 25% by weight based on the total weight of the personal care composition.

[0019] According to embodiment 6, a personal care composition according to any of the foregoing embodiments is provided, the personal care composition further comprising an α-hydroxy acid and / or a salt thereof.

[0020] According to embodiment 7, a personal care composition according to embodiment 6 is provided, wherein the α-hydroxy acid and / or its salt includes mandelic acid, lactic acid, malic acid, tartaric acid, phytic acid, its salt, or a combination of two or more thereof.

[0021] According to embodiment 8, a personal care composition according to embodiment 6 or embodiment 7 is provided, wherein the α-hydroxy acid and / or its salt are present in an amount ranging from about 5% by weight to about 25% by weight, based on the total weight of the personal care composition.

[0022] According to embodiment 9, a personal care composition according to any of the foregoing embodiments is provided, the personal care composition further comprising an anti-acne agent selected from: keratolytic agents, retinoids, retinoic acid, adapalene, tazarotene, lipoic acid, benzoyl peroxide, chlorhexidine gluconate, octopirox, tetracycline, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, and 3,4,4'-trichlorobanilide. Nicotinamide, tea tree oil, rofecoxib, azelaic acid and its derivatives, phenoxyethanol, phenoxypropanol, phenoxyisopropanol, ethyl acetate, clindamycin, erythromycin, meclocycline, sebostats, minocycline, moxifloxacin, N-acetylcysteine, naflufloxacin, octopirox, prulifloxacin, sitafloxacin, sodium sulfacetamide, spironolactone, sulfacetamide, sulfur, tazarotene, retinoic acid, euricacin, metronidazole, ornidazole, urea, and combinations thereof.

[0023] According to embodiment 10, a personal care composition according to any of the foregoing embodiments is provided, further comprising an antioxidant selected from: camellia (amellia japonica) extract, quercetin, green tea, soybean, milk thistle, algae, aloe vera, angelica, bitter orange, coffee, coptis, grapefruit, scutellaria (hoellen), honeysuckle, coix seed, gromwell root, mulberry, peony, kudzu, rice, safflower, and combinations of two or more thereof.

[0024] According to embodiment 11, a personal care composition according to any of the foregoing embodiments is provided, wherein the moisturizer is selected from sorbitol, butylene glycol, 1,3-propanediol, glycerin, polyethylene glycol, polyglutamic acid, saccharide isomers, and combinations thereof.

[0025] According to embodiment 12, a personal care composition according to any of the foregoing embodiments is provided, wherein the moisturizer comprises a saccharide isomer.

[0026] According to embodiment 13, a personal care composition according to embodiment 11 or embodiment 12 is provided, wherein the moisturizer is present in an amount of about 0.01% by weight to about 5% by weight based on the total weight of the personal care composition.

[0027] According to implementation scheme 14, a personal care composition is provided, comprising:

[0028] Adapalene oil ester;

[0029] α-hydroxy acids and / or their salts; and

[0030] Carbohydrate isomers.

[0031] According to embodiment 15, a personal care composition according to embodiment 14 is provided, wherein the α-hydroxy acid and / or its salt is selected from mandelic acid, lactic acid, malic acid, tartaric acid, phytic acid, its salts, and combinations of two or more thereof.

[0032] According to embodiment 16, a personal care composition according to embodiment 14 or embodiment 15 is provided, further comprising a β-hydroxy acid and / or its salt, said β-hydroxy acid and / or its salt including salicylic acid, β-hydroxybutyric acid, scopolamine, trosococcal acid, its salt, or a combination of two or more thereof.

[0033] According to embodiment 17, a personal care composition according to any of the foregoing embodiments is provided, further comprising licorice extract.

[0034] According to implementation scheme 18, a personal care composition is provided, comprising:

[0035] Adapalene oil ester;

[0036] α-hydroxy acids and / or their salts; and

[0037] Lipoic acid and / or its salts.

[0038] According to embodiment 19, a personal care composition according to embodiment 18 is provided, wherein the α-hydroxy acid and / or its salt is selected from mandelic acid, lactic acid, malic acid, tartaric acid, phytic acid, its salts, and combinations of two or more thereof.

[0039] According to embodiment 20, a personal care composition according to embodiment 18 or embodiment 19 is provided, further comprising a β-hydroxy acid and / or a salt thereof, said β-hydroxy acid and / or a salt thereof selected from salicylic acid, β-hydroxybutyric acid, scopolamine, trosococcal acid, their salts, and combinations thereof.

[0040] According to embodiment 21, a personal care composition according to any one of embodiments 18 to 20 is provided, further comprising licorice extract.

[0041] According to embodiment 22, a personal care composition is provided, comprising:

[0042] retinoids;

[0043] psoralen;

[0044] α-hydroxy acids or their salts; and

[0045] A carrier acceptable for cosmetics.

[0046] According to embodiment 23, a personal care composition according to embodiment 22 is provided, wherein the α-hydroxy acid or a salt thereof is selected from mandelic acid, lactic acid, malic acid, tartaric acid, phytic acid, their salts, and combinations of two or more thereof.

[0047] According to embodiment 24, a personal care composition according to embodiment 22 or embodiment 23 is provided, wherein the retinoid comprises adapalene oil ester or a derivative thereof.

[0048] According to embodiment 25, a personal care composition according to any one of embodiments 22 to 24 is provided, further comprising an anti-acne agent selected from: keratolytic agents, retinoids, retinoic acid, adapalene, tazarotene, lipoic acid, benzoyl peroxide, chlorhexidine gluconate, piroctone olamine, tetracycline, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 3,4,4'-trichlorocarbonyl aniline, nicotinamide, tea tree oil, rofecoxib, nonyl alcohol. Diacids and their derivatives, phenoxyethanol, phenoxypropanol, phenoxyisopropanol, ethyl acetate, clindamycin, erythromycin, meclocycline, sebostats, minocycline, moxifloxacin, N-acetylcysteine, naflufloxacin, piroctone ethanolamine salt, prulifloxacin, sitafloxacin, sodium sulfacetamide, spironolactone, sulfacetyl, sulfur, tazarotene, retinoic acid, eufloxacin, metronidazole, ornidazole, urea, and combinations of both or more thereof.

[0049] According to implementation scheme 26, a personal care composition according to any one of implementation schemes 22 to 25 is provided, further comprising an antioxidant selected from: camellia extract, quercetin, green tea, soybean, milk thistle, algae, aloe vera, angelica, bitter orange, coffee, coptis, grapefruit, scutellaria, honeysuckle, coix seed, gromwell root, mulberry, peony, kudzu, rice, safflower, and combinations of two or more thereof.

[0050] According to embodiment 27, a personal care composition according to any one of embodiments 22 to 26 is provided, further comprising a moisturizer selected from sorbitol, butylene glycol, 1,3-propanediol, glycerin, polyethylene glycol, polyglutamic acid, saccharide isomers, and combinations thereof.

[0051] According to embodiment 28, a personal care composition according to embodiment 27 is provided, wherein the moisturizer comprises a saccharide isomer.

[0052] According to embodiment 29, a personal care composition according to any one of embodiments 22 to 28 is provided, wherein the personal care composition is in the form of: exfoliant; serum; lotion; cream; balm; and ointment.

[0053] According to embodiment 30, a personal care composition according to any of the foregoing embodiments is provided, the personal care composition having a pH of about 2.5 to about 4.5.

[0054] According to embodiment 31, a personal care composition according to embodiment 30 is provided, wherein the pH is from about 3.1 to about 4.1.

[0055] According to embodiment 32, a method is provided for treating, preventing, or improving symptoms associated with acne, post-acne scars, post-acne texture and skin color, pigmentation, clogged pores, and / or inflammation, the method comprising: applying a personal care composition according to any of the foregoing embodiments to the skin surface of a subject in need.

[0056] According to embodiment 33, any of the compositions described herein are provided for use in treating or preventing acne, post-acne scars, post-acne texture and skin tone, pigmentation, clogged pores and / or inflammation. Attached Figure Description

[0057] Figure 1 This is a bar graph illustrating the effect of a non-limiting example skin care composition according to aspects of the invention on TGFB2 and VEGF expression.

[0058] Figure 2 This is a bar graph illustrating the effect of a non-limiting example skin care composition according to an aspect of the invention on AQP3 expression.

[0059] Figure 3 This is a bar graph illustrating the effects of a non-limiting example skin care composition according to aspects of the invention on sebum, erythema index, texture count, and pore size. Detailed Implementation

[0060] For illustrative purposes, the principles of the invention are described by reference to various exemplary embodiments thereof. While certain embodiments of the invention have been specifically described herein, those skilled in the art will readily recognize that the same principles are equally applicable to and can be used in other devices and methods. Before detailing the disclosed embodiments of the invention, it should be understood that the invention is not limited in its application to the details of any particular embodiment disclosed herein. The terminology used herein is for descriptive purposes and not for limiting purposes.

[0061] As used herein and in the appended claims, the singular form includes the plural reference unless the context otherwise requires. The singular form of any class of ingredients refers not only to a single chemical substance within that class but also to mixtures of such chemical substances. The terms “an,” “one or more,” and “at least one” are used interchangeably herein. The terms “comprising,” “including,” and “having” are used interchangeably. The term “comprising” should be interpreted as “including, but not limited to.”

[0062] As used throughout, a range is used as a shorthand to describe the individual values ​​within the range and each value. Any value within the range can be chosen as an endpoint of the range. Thus, the range 1 to 5 specifically includes 1, 2, 3, 4, and 5, as well as subranges such as 2 to 5, 3 to 5, 2 to 3, 2 to 4, 1 to 4, etc.

[0063] The term “about” refers to any number within 10% of that number when referring to a number. For example, the phrase “about 2% by weight” refers to a number between 1.8% by weight and 2.2% by weight, and includes both 1.8% by weight and 2.2% by weight.

[0064] All references cited in this document are incorporated herein by reference in their entirety. In the event of any conflict between the limitations set forth in this disclosure and the limitations set forth in the cited references, the limitations set forth in this disclosure shall prevail.

[0065] Unless otherwise stated, abbreviations and symbols used herein have their ordinary meanings. The abbreviation “weight%” means a percentage by weight relative to the personal care composition. The symbol “°” refers to a degree, such as a temperature or angle. The symbols “h,” “min,” “mL,” “nm,” and “μm” refer to hours, minutes, milliliters, nanometers, and micrometers, respectively. The abbreviation “UV-VIS,” referring to a spectrometer or spectroscopy, means ultraviolet-visible. The abbreviation “rpm” means revolutions per minute.

[0066] When referring to chemical structures and names, the symbols "C", "H", and "O" represent carbon, hydrogen, and oxygen, respectively. The symbols "–", "=", and "≡" represent single, double, and triple bonds, respectively.

[0067] As used herein, “volatile” means having a flash point below approximately 100°C. As used herein, “non-volatile” means having a flash point above approximately 100°C.

[0068] Any member of the species list used to exemplify or define a genus may be distinct from, overlap with, be a subset of, be equivalent to, be nearly identical to, or be identical to any other member of the species list. Furthermore, unless explicitly stated otherwise, for example when enumerating the Markush groups, the list of species used to define or exemplify a genus is open-ended, and it is permissible for other species to exist that define or exemplify the genus that are exactly as good as or better than any other species listed.

[0069] The phrases “its mixture,” “its combination,” or “combination of two or more thereof” do not require that the mixture contain all of A, B, C, D, E, and F (although it may contain all of A, B, C, D, E, and F). Rather, it indicates a mixture that may contain any two or more of A, B, C, D, E, and F. In other words, it is equivalent to the phrase “a mixture of one or more elements selected from A, B, C, D, E, and F, and any two or more of A, B, C, D, E, and F.” Similarly, the term “its salt” also refers to “its various salts.” Therefore, when this disclosure refers to "elements selected from A, B, C, D, E, F, their salts, and mixtures thereof", it can mean one or more of A, B, C, D, and F, one or more of salts of A, B, C, D, E, and F, or a mixture of any two of salts of A, B, C, D, E, F, salts of A, B, C, D, E, and F.

[0070] All components and elements affirmatively set forth in this disclosure may be negatively excluded from the claims. In other words, the personal care compositions of this disclosure may contain no or substantially no components and elements affirmatively recited throughout this disclosure. In some cases, the personal care compositions of this disclosure may contain substantially no non-incidental amounts of the ingredients or compounds described herein. A non-incidental amount of an ingredient or compound is the amount of that ingredient or compound added alone to the personal care composition. For example, a personal care composition may contain substantially no non-incidental amounts of an ingredient or compound, although such an ingredient or compound may be present as part of raw materials included in a blend of two or more compounds.

[0071] Some of the identified different categories of components may overlap. In cases where overlap is possible and a personal care composition contains two components (or more than two overlapping components), overlapping compounds do not indicate more than one component. For example, some compounds may be called both a β-hydroxy acid and an anti-acne agent. If a particular personal care composition contains salicylic acid (which may be called both a β-hydroxy acid and an anti-acne agent), then salicylic acid will function as either a β-hydroxy acid or an anti-acne agent, not both.

[0072] For readability purposes, chemical functional groups are presented in their adjective form; for each of these adjectives, the word "group" is assumed to be used. For example, the adjective "alkyl" without a noun should be interpreted as "alkyl group".

[0073] This invention relates to personal care compositions, and in some cases to skin care exfoliants. According to one aspect, a personal care composition is provided comprising adapalene oleyl ester; β-hydroxy acid and / or its salt; and a moisturizer. According to another aspect, a personal care composition is provided comprising adapalene oleyl ester, α-hydroxy acid and / or its salt, and a saccharide isomer. According to yet another aspect, a personal care composition is provided comprising adapalene oleyl ester, α-hydroxy acid and / or its salt, and lipoic acid and / or its salt. In some embodiments, the personal care composition may be a skin care exfoliant.

[0074] Depending on the specific combination of other components, the form of the personal care composition, and / or the intended use of the formulation (e.g., serum, skin care exfoliant, etc.), suitable components, such as those listed below, may be included in or excluded from the formulation of a personal care composition. A personal care composition may be a skin care composition, such as a skin care exfoliant.

[0075] Personal care compositions may contain adapalene oil esters in varying amounts. Preferably, the personal care composition contains an effective amount of adapalene oil esters. In some cases, the amount of adapalene oil esters present in the personal care composition is from about 0.05% by weight to about 7% by weight, based on the total weight of the personal care composition. For example, based on the total weight of the personal care composition, the personal care composition may contain adapalene oil esters in the following amounts: from about 0.05% to about 5% by weight, from about 0.05% by weight to about 3% by weight, from about 0.05% by weight to about 2% by weight, from about 0.05% by weight to about 1% by weight, from about 0.05% by weight to about 0.75% by weight, from about 0.05% by weight to about 0.5% by weight, from about 0.05% by weight to about 0.25% by weight, from about 0.05% by weight to about 0.1% by weight; from about 0.1% by weight to about 7% by weight, from about 0.1% by weight to about 7% by weight, from about 0.05% by weight to about 7% by weight. 0.1 wt% to about 5 wt%, about 0.1 wt% to about 3 wt%, about 0.1 wt% to about 2 wt%, about 0.1 wt% to about 1 wt%, about 0.1 wt% to about 0.75 wt%, about 0.1 wt% to about 0.5 wt%, about 0.1 wt% to about 0.25 wt%; about 0.15 wt% to about 7 wt%, about 0.15 wt% to about 5 wt%, about 0.15 wt% to about 3 wt%, about 0.15 wt% to about 2 wt%, about 0.15 wt% to about 1 wt%, about 0. 15 wt% to about 0.75 wt%, about 0.15 wt% to about 0.5 wt%, about 0.15 wt% to about 0.25 wt%; about 0.4 wt% to about 7 wt%, about 0.4 wt% to about 5 wt%, about 0.4 wt% to about 3 wt%, about 0.4 wt% to about 2 wt%, about 0.4 wt% to about 1 wt%, about 0.4 wt% to about 0.75 wt%; about 0.8 wt% to about 7 wt%, about 0.8 wt% to about 5 wt%, about 0.8 wt% to about 3 wt%, about 0.8 wt%. From about 2 wt% by weight, from about 0.8 wt% by weight to about 1 wt% by weight; from about 1.2 wt% by weight to about 7 wt%, from about 1.2 wt% by weight to about 5 wt%, from about 1.2 wt% by weight to about 3 wt%, from about 1.2 wt% by weight to about 2 wt% by weight; from about 1.6 wt% by weight to about 7 wt%, from about 1.6 wt% by weight to about 5 wt%, from about 1.6 wt% by weight to about 3 wt%, from about 1.6 wt% by weight to about 2 wt% by weight; from about 2 wt% by weight to about 7 wt%, from about 2 wt% by weight to about 5 wt%, from about 2 wt% by weight to about 3 wt%, or any range or subrange thereof.

[0076] Personal care compositions typically contain one or more β-hydroxy acids and / or their salts, for example, in amounts from about 5% to about 25% by weight, based on the total weight of the personal care composition. For example, the total amount of β-hydroxy acids and / or their salts present in the personal care composition may be from about 5% to about 22% by weight, from about 5% to about 19% by weight, from about 5% to about 17% by weight, from about 5% to about 15% by weight, from about 5% to about 13% by weight, from about 5% to about 11% by weight, from about 5% to about 9% by weight; from about 8% to about 25% by weight, from about 8% to about 22% by weight, from about 8% to about 19% by weight, from about 8% to about 17% by weight, from about 8% to about 15% by weight, from about 8% to about 13% by weight, from about 8% to about 11% by weight; from about 10% by weight to about 25% by weight, from about 10% by weight to about 22% by weight, from about 10% by weight... % to about 19 wt%, about 10 wt% to about 17 wt%, about 10 wt% to about 15 wt%, about 10 wt% to about 13 wt%; about 12 wt% to about 25 wt%, about 12 wt% to about 22 wt%, about 12 wt% to about 19 wt%, about 12 wt% to about 17 wt%, about 12 wt% to about 15 wt%; about 14 wt% to about 25 wt%, about 14 wt% to about 22 wt%, about 14 wt% to about 19 wt%, about 14 wt% to about 17 wt%; about 16 wt% to about 25 wt%, about 16 wt% to about 22 wt%, about 16 wt% to about 19 wt%; about 18 wt% to about 25 wt%, about 18 wt% to about 22 wt%, or any range or subrange thereof.

[0077] Personal care formulations typically contain one or more β-hydroxy acids and / or their salts. Non-limiting examples of β-hydroxy acids include salicylic acid, propionic acid, β-hydroxybutyric acid, β-hydroxy-β-methylbutyric acid, β-phenyl-lactic acid, β-phenylpyruvic acid, carnitine, their salts, and combinations thereof. In some cases, the β-hydroxy acid and / or its salt may be selected from salicylic acid, esters of salicylic acid, sodium salicylate, β-hydroxybutyric acid, scopolamine, trasococcal acid, β-hydroxy acids obtained from white willow bark extract and / or holly leaves, their salts, and combinations thereof. In some embodiments, the β-hydroxy acid comprises salicylic acid and / or sodium salicylate, β-hydroxy acids from willow bark extract, or combinations thereof. In one embodiment, the β-hydroxy acid and / or its salt is salicylic acid and / or sodium salicylate.

[0078] The personal care formulations of the present invention may contain one or more alpha-hydroxy acids and / or their salts. Based on the total weight of the personal care composition, the total amount of alpha-hydroxy acids and / or their salts present in the personal care composition may be from about 5% by weight to about 25% by weight. In some embodiments, based on the total weight of the personal care composition, the amount of alpha-hydroxy acids and / or their salts present in the personal care composition is from about 5% by weight to about 22% by weight, from about 5% by weight to about 20% by weight, from about 5% by weight to about 19% by weight, from about 5% by weight to about 17% by weight, from about 5% by weight to about 15% by weight, from about 5% by weight to about 13% by weight, from about 5% by weight to about 11% by weight, from about 5% by weight to about 9% by weight; from about 8% by weight to about 25% by weight, from about 8% by weight to about 22% by weight, from about 8% by weight to about 19% by weight, from about 8% by weight to about 17% by weight, from about 8% by weight to about 15% by weight, from about 8% by weight to about 13% by weight, from about 8% by weight to about 11% by weight; from about 10% by weight to about 25% by weight, from about 10% by weight to about 22% by weight. %, about 10% to about 19% by weight, about 10% to about 17% by weight, about 10% to about 15% by weight, about 10% to about 13% by weight; about 12% to about 25% by weight, about 12% to about 22% by weight, about 12% to about 19% by weight, about 12% to about 17% by weight, about 12% to about 15% by weight; about 14% to about 25% by weight, about 14% to about 22% by weight, about 14% to about 19% by weight, about 14% to about 17% by weight; about 16% to about 25% by weight, about 16% to about 22% by weight, about 16% to about 19% by weight; about 18% to about 25% by weight, about 18% to about 22% by weight, or any range or subrange thereof.

[0079] Personal care compositions may contain one or more α-hydroxy acids and / or their salts. For example, a personal care formulation may contain one or more α-hydroxy acids and / or their salts, such as those selected from C3 to C7 α-hydroxy acids or C4 to C6 α-hydroxy acids. Examples of α-hydroxy acids and / or their salts include glycolic acid, citric acid, lactic acid, malic acid, mandelic acid, ascorbic acid, α-hydroxybutyric acid, α-hydroxyisobutyric acid, α-hydroxyisocaproic acid, arbutinic acid, α-hydroxyisovaleric acid, ethyl pyruvate, galacturonic acid, glucoheponic acid, glucoheponic acid-1,4-lactone, gluconic acid, gluconic acid lactone, glucuronic acid, glucuronic acid lactone, glycolic acid, isopropyl pyruvate, methyl pyruvate, viscous acid, pyruvate, sulcidiic acid, sulcidiic acid-1,4-lactone, tartaric acid, malonic acid, and their salts. In some embodiments, the personal care formulation contains a salt of an α-hydroxy acid. The salt of the α-hydroxy acid is preferably a sodium or potassium salt. In at least one embodiment, the salt is a sodium salt (i.e., the cation bound to the salt is sodium).

[0080] In some embodiments, one or more α-hydroxy acids include, but are not limited to, mandelic acid, glycolic acid, citric acid, lactic acid, malic acid, tartaric acid, phytic acid, hydroxyoctanoic acid, hydroxydecanoic acid, glutaric acid, gluconic acid, their salts, or combinations thereof. For example, the α-hydroxy acid and / or its salts may be selected from citric acid, mandelic acid, glycolic acid, lactic acid, their salts, or combinations thereof. In some cases, the α-hydroxy acid is selected from mandelic acid, lactic acid, malic acid, tartaric acid, phytic acid, tartaric acid, α-hydroxyglutaric acid, gluconic acid, their salts, or combinations thereof. In still other cases, the α-hydroxy acid or its salts are selected from lactic acid, malic acid, sodium D-gluconate, their salts, or combinations thereof. In at least one embodiment, the α-hydroxy acid is lactic acid.

[0081] Personal care compositions may be formulated in a weight ratio of the total amount of β-hydroxy acids and / or their salts to the total amount of α-hydroxy acids and / or their salts of about 1:1 to about 1:11; about 1:1 to about 1:10; about 1:1 to about 1:9; about 1:1 to about 1:8; about 1:1 to about 1:7; about 1:1 to about 1:6; about 1:1 to about 1:5; about 1:1 to about 1:4; about 1:1 to about 1:3; about 1:1 to about 1:2; or about 1:1.

[0082] Personal care compositions may contain one or more anti-acne agents. Based on the total weight of the personal care composition, the amount of anti-acne agent present in the oral care composition may be from about 0.01% by weight to about 20% by weight. For example, the personal care composition may contain one or more anti-acne agents in the following total amounts: about 0.01% by weight to about 35% by weight, about 0.01% by weight to about 30% by weight, about 0.05% by weight to about 30% by weight, about 0.05% by weight to about 29% by weight, about 0.1% by weight to about 30% by weight, about 0.2% by weight to about 30% by weight, about 0.25% by weight to about 30% by weight, about 0.5% by weight to about 30% by weight; about 1% by weight to about 30% by weight, about 2.5% by weight to about 30% by weight, about 5% by weight to about 30% by weight, about 7.5% by weight to about 30% by weight, about 10% by weight to about 30% by weight, or about 12.5% ​​by weight to about 30% by weight.

[0083] Based on the total weight of the personal care composition, the amount of anti-acne agent present in the oral care composition can be from about 0.01% by weight to about 7% by weight. For example, based on the total weight of the personal care composition, the personal care composition may contain one or more anti-acne agents in the following total amounts: about 0.01% by weight to about 5% by weight, about 0.01% by weight to about 3% by weight, about 0.01% by weight to about 2% by weight, about 0.01% by weight to about 1% by weight, about 0.01% by weight to about 0.75% by weight, about 0.01% by weight to about 0.5% by weight, about 0.01% by weight to about 0.25% by weight, about 0.01% by weight to about 0.1% by weight; about 0.05% by weight to about 7% by weight, about 0.05% by weight to about 5% by weight, about 0.05% by weight to about 3% by weight, about 0.0% by weight. 5 wt% to about 2 wt%, about 0.05 wt% to about 1 wt%, about 0.05 wt% to about 0.75 wt%, about 0.05 wt% to about 0.5 wt%, about 0.05 wt% to about 0.25 wt%, about 0.05 wt% to about 0.1 wt%; about 0.1 wt% to about 7 wt%, about 0.1 wt% to about 5 wt%, about 0.1 wt% to about 3 wt%, about 0.1 wt% to about 2 wt%, about 0.1 wt% to about 1 wt%, about 0.1 wt% to about 0.75 wt%, about 0.1 wt% to about 0.5 wt%, about 0.1 wt% to about 0.25 wt%; about 0.15 wt% From about 7 wt%, about 0.15 wt% to about 5 wt%, about 0.15 wt% to about 3 wt%, about 0.15 wt% to about 2 wt%, about 0.15 wt% to about 1 wt%, about 0.15 wt% to about 0.75 wt%, about 0.15 wt% to about 0.5 wt%, about 0.15 wt% to about 0.25 wt%; about 0.4 wt% to about 7 wt%, about 0.4 wt% to about 5 wt%, about 0.4 wt% to about 3 wt%, about 0.4 wt% to about 2 wt%, about 0.4 wt% to about 1 wt%, about 0.4 wt% to about 0.75 wt%; about 0.8 wt% to about 7 wt%, about 0. 8 wt% to about 5 wt%, about 0.8 wt% to about 3 wt%, about 0.8 wt% to about 2 wt%, about 0.8 wt% to about 1 wt%; about 1 wt% to about 2 wt%; about 1.2 wt% to about 7 wt%, about 1.2 wt% to about 5 wt%, about 1.2 wt% to about 3 wt%, about 1.2 wt% to about 2 wt%; about 1.6 wt% to about 7 wt%, about 1.6 wt% to about 5 wt%, about 1.6 wt% to about 3 wt%, about 1.6 wt% to about 2 wt%; about 2 wt% to about 7 wt%, about 2 wt% to about 5 wt%, about 2 wt% to about 3 wt%, or any range or subrange thereof.

[0084] Examples of anti-acne agents include, but are not limited to, keratolytic agents such as salicylic acid and its derivatives; retinoids such as retinoic acid, tretinoin, adapalene oleyl ester, adapalene, tazarotene; sulfur-containing D- and L-amino acids and their derivatives and salts; lipoic acid; antibiotics and antimicrobial agents such as benzoyl peroxide, chlorhexidine gluconate, piroctone olamine, tetracycline, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 3,4,4'-trichlorocarbonylaniline, nicotinamide, tea tree oil, rofecoxib, azelaic acid and its derivatives, phenoxyethanol, phenoxypropanol, phenoxyisopropanol, ethyl acetate, clindamycin, erythromycin, and methylchlorocycline; sebostats such as flavonoids; and bile salts such as scymnol sulfate and its derivatives, deoxycholates, and bile salts; and combinations of both or more thereof. Examples of retinoids include retinoic acid, isotretinoin, morphine, adapalene oleyl ester, adapalene, tazarotene, azelaic acid, and retinol. In some embodiments, the retinoids are present in an amount of about 0.1% by weight to about 1% by weight, based on the total weight of the personal care composition.

[0085] In some embodiments, one or more anti-acne agents include: keratolytic agents, retinoids, retinoic acid, adapalene, tazarotene, lipoic acid, benzoyl peroxide, chlorhexidine gluconate, piroctone olamine, tetracycline, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 3,4,4'-trichlorocarbonylaniline, nicotinamide, tea tree oil, rofecoxib, azelaic acid and its derivatives, phenoxyethanol, phenoxypropanol, phenoxyisopropanol, ethyl acetate, clindamycin, erythromycin, meclocycline, sebostats, minocycline, moxifloxacin, N-acetylcysteine, naflufloxacin, piroctone olamine, prulifloxacin, sitafloxacin, sodium sulfacetamide, spironolactone, sulfacetamide, sulfur, tazarotene, retinoic acid, eulifloxacin, metronidazole, ornidazole, urea, and combinations of two or more thereof.

[0086] Personal care compositions may contain two or more anti-acne agents. For example, a personal care composition may contain three, four, five, six or seven anti-acne agents, and / or may contain a series of anti-acne agents formed therefrom.

[0087] In some implementations, the anti-acne agent may be selected from acetretin, adapalene, retinoic acid, azelaic acid, azithromycin, benzoyl peroxide, besifloxacin, bexarotin, cefotaxime, cefoxitin, cefuroxime, cefepime, ceftriaxone, cefotaxime, clindamycin, erythromycin, etretinate, garafloxacin, glycolic acid, isotretinoin, lactic acid, minocycline, moxifloxacin, N-acetylcysteine, naflufloxacin, piroctone olamine, phenoxyethanol, phenoxypropanol, prulifloxacin, pyruvate, radizolide (RX-1741), retamorin, retinoid, roxithromycin, salicylic acid, sitafloxacin, sodium sulfacetamide, spironolactone, sulfacetamide, sulfur, tazarotene, retinoic acid, eulifloxacin, metronidazole, ornidazole, urea, and combinations of two or more thereof.

[0088] Antiacne agents may be selected from antimicrobial peptides possessing activity against Propionibacterium acnes (P. acnes). Antimicrobial peptides may be naturally occurring peptides or analogs thereof, or they may be synthetic peptides. As used herein, "analyte" refers to a naturally occurring antimicrobial peptide that has been chemically modified to improve its effectiveness and / or reduce its toxicity. Antimicrobial peptides may be peptides known to be effective against Gram-positive bacteria. Non-limiting examples include thiamethoxams such as nisin, subtilisin, epidermin, and gallidermin; defensins; silkworm antimicrobial peptides, such as flesh fly antimicrobial peptides; silkworm bactericidal peptides, such as silkworm bactericidal peptide A, bactericides, and lepidopteran; Xenopus antimicrobial peptides; bee venom peptides; histamine; brevinin; and combinations thereof.

[0089] In some embodiments, the anti-acne agent may be a fatty acid ester of free fatty acid (FFA), fatty acid derivatives, or propylene glycol (PG) or glycerol (G) derivatives, or any combination thereof. Examples include lauric acid, stearic acid, myristic acid, oleic acid, linoleic acid, myristone acid, palmitoleic acid, linolenic acid, sapienic acid, various polyunsaturated fatty acids (PUFAs), propylene glycol monolaurate, glyceryl monolaurate and / or glyceryl dilaurate, propylene glycol monooleate, glyceryl monooleate and / or glyceryl dioleate, or combinations thereof.

[0090] Personal care compositions may contain one or more antioxidants. For example, based on the total weight of the personal care composition, the composition may contain antioxidants in amounts from about 0.01% to about 7% by weight. In some cases, based on the total weight of the personal care composition, the composition may contain one or more anti-acne agents in the following total amounts: about 0.01% to about 5% by weight, about 0.01% to about 3% by weight, about 0.01% to about 2% by weight, about 0.01% to about 1% by weight, about 0.01% to about 0.75% by weight, about 0.01% to about 0.5% by weight, about 0.01% to about 0.25% by weight, about 0.01% to about 0.1% by weight; about 0.05% to about 7% by weight, about 0.05% to about 5% by weight, about 0.05% to about 3% by weight. %, about 0.05 wt% to about 2 wt%, about 0.05 wt% to about 1 wt%, about 0.05 wt% to about 0.75 wt%, about 0.05 wt% to about 0.5 wt%, about 0.05 wt% to about 0.25 wt%, about 0.05 wt% to about 0.1 wt%; about 0.1 wt% to about 7 wt%, about 0.1 wt% to about 5 wt%, about 0.1 wt% to about 3 wt%, about 0.1 wt% to about 2 wt%, about 0.1 wt% to about 1 wt%, about 0.1 wt% to about 0.75 wt%, about 0.1 wt% to about 0.5 wt%, about 0.1 wt% to about 0.25 wt%; About 0.15 wt% to about 7 wt%, about 0.15 wt% to about 5 wt%, about 0.15 wt% to about 3 wt%, about 0.15 wt% to about 2 wt%, about 0.15 wt% to about 1 wt%, about 0.15 wt% to about 0.75 wt%, about 0.15 wt% to about 0.5 wt%, about 0.15 wt% to about 0.25 wt%; about 0.4 wt% to about 7 wt%, about 0.4 wt% to about 5 wt%, about 0.4 wt% to about 3 wt%, about 0.4 wt% to about 2 wt%, about 0.4 wt% to about 1 wt%, about 0.4 wt% to about 0.75 wt%; about 0.8 wt%. From about 7 wt%, about 0.8 wt% to about 5 wt%, about 0.8 wt% to about 3 wt%, about 0.8 wt% to about 2 wt%, about 0.8 wt% to about 1 wt%; about 1.2 wt% to about 7 wt%, about 1.2 wt% to about 5 wt%, about 1.2 wt% to about 3 wt%, about 1.2 wt% to about 2 wt%; about 1.6 wt% to about 7 wt%, about 1.6 wt% to about 5 wt%, about 1.6 wt% to about 3 wt%, about 1.6 wt% to about 2 wt%; about 2 wt% to about 7 wt%, about 2 wt% to about 5 wt%, about 2 wt% to about 3 wt%, or any range or subrange thereof.

[0091] Additionally or alternatively, the personal care composition may contain one or more antioxidants. Based on the total weight of the personal care composition, the antioxidant may be present in the personal care composition in an amount from about 0.01 wt% to about 7 wt%. For example, based on the total weight of the personal care composition, the personal care composition may be formulated to contain antioxidants in the following ranges: about 0.01 wt% to about 5 wt%, about 0.01 wt% to about 3 wt%, about 0.01 wt% to about 2 wt%, about 0.01 wt% to about 1 wt%, about 0.01 wt% to about 0.75 wt%, about 0.01 wt% to about 0.5 wt%, about 0.01 wt% to about 0.25 wt%, about 0.01 wt% to about 0.1 wt%; about 0.05 wt% to about 7 wt%, about 0.05 wt% to about 5 wt%, about 0.05 wt% to about 3 wt%, about 0. 0.5 wt% to about 2 wt%, about 0.05 wt% to about 1 wt%, about 0.05 wt% to about 0.75 wt%, about 0.05 wt% to about 0.5 wt%, about 0.05 wt% to about 0.25 wt%, about 0.05 wt% to about 0.1 wt%; about 0.1 wt% to about 7 wt%, about 0.1 wt% to about 5 wt%, about 0.1 wt% to about 3 wt%, about 0.1 wt% to about 2 wt%, about 0.1 wt% to about 1 wt%, about 0.1 wt% to about 0.75 wt%, about 0.1 wt% to about 0.5 wt%, about 0.1 wt% to about 0.25 wt%; about 0.1 5 wt% to about 7 wt%, about 0.15 wt% to about 5 wt%, about 0.15 wt% to about 3 wt%, about 0.15 wt% to about 2 wt%, about 0.15 wt% to about 1 wt%, about 0.15 wt% to about 0.75 wt%, about 0.15 wt% to about 0.5 wt%, about 0.15 wt% to about 0.25 wt%; about 0.4 wt% to about 7 wt%, about 0.4 wt% to about 5 wt%, about 0.4 wt% to about 3 wt%, about 0.4 wt% to about 2 wt%, about 0.4 wt% to about 1 wt%, about 0.4 wt% to about 0.75 wt%; about 0.8 wt% to about 7 wt%, about 0.8 wt% to about 5 wt%, about 0.8 wt% to about 3 wt%, about 0.8 wt% to about 2 wt%, about 0.8 wt% to about 1 wt%; about 1.2 wt% to about 7 wt%, about 1.2 wt% to about 5 wt%, about 1.2 wt% to about 3 wt%, about 1.2 wt% to about 2 wt%; about 1.6 wt% to about 7 wt%, about 1.6 wt% to about 5 wt%, about 1.6 wt% to about 3 wt%, about 1.6 wt% to about 2 wt%; about 2 wt% to about 7 wt%, about 2 wt% to about 5 wt%, about 2 wt% to about 3 wt%, or any range or subrange thereof.

[0092] One or more antioxidants may include camellia extract, quercetin, green tea, soybean, milk thistle, algae, aloe vera, angelica, bitter orange, coffee, coptis, grapefruit, scutellaria, honeysuckle, coix seed, lithospermum, mulberry, peony, kudzu, rice, safflower, or combinations thereof. Personal care compositions may also contain antioxidants selected from beta-carotene, phytosterols, and combinations thereof.

[0093] Other antioxidants include vitamin C and its derivatives, including ascorbic acid, sodium ascorbate, and fat-soluble esters such as tetrahexyldecyl ascorbate and ascorbate palmitate, magnesium ascorbate phosphate, ascorbate glucoside, glucosamine ascorbate, and ascorbate acetate. In some cases, plant extracts containing high levels of vitamin C, such as camu camu (Myrciaria dubia), golden privet, and Emblica officinalis, can be used, along with bioflavonoids from rosehip and citrus fruits. Other antioxidants include sesame (Sesamum indicum) or sesame lignin (a sesame-related fiber compound). Antioxidants can also be bioflavonoids, such as hesperidin methyl chalcone.

[0094] Antioxidants can be selected from tocopherols (e.g., d-α-tocopherol, d-β-tocopherol, d-γ-tocopherol, d-δ-tocopherol), tocotrienols (e.g., d-α-tocotrienol, d-β-tocotrienol, d-γ-tocotrienol, d-δ-tocotrienol), vitamin E (α-tocopheryl acetate), and combinations thereof. These compounds can be isolated from natural sources, prepared by synthetic methods, or mixtures thereof. Vitamin E preparations rich in tocotrienols can be obtained by fractionating vitamin E preparations to remove some of the tocopherols and recovering preparations with higher concentrations of tocotrienols. Useful tocotrienols include, for example, natural products isolated from wheat germ oil, cereals, or palm oil using high-performance liquid chromatography, or from barley, distiller's grains, or oats by alcohol extraction and / or molecular distillation. As used herein, the term "tocotrienol" includes both tocotrienol-rich fractions obtained from these natural products and pure compounds. Enhanced glutathione peroxidase activity protects the skin from oxidative damage.

[0095] In addition, carotenoids, especially lutein-type carotenoids, can be useful antioxidants. Lutein-type carotenoids include molecules such as lutein, canthaxantin, cryptoxanthin, zeaxanthin, and astaxanthin. Lutein protects compounds such as vitamin A, vitamin E, and other carotenoids.

[0096] Personal care compositions may contain one or more skin soothing agents, such as aloe vera extract, allantoin, licorice extract, glycyrrhizin, or combinations thereof. In some preferred embodiments, the personal care composition contains two or more skin soothing agents. For example, the personal care composition may contain two, three, four, five, six, seven, or any range thereof of skin soothing agents. When two or more skin soothing agents are incorporated into a personal care composition, preferably at least one skin soothing agent is licorice extract. For example, in at least one preferred embodiment, the personal care composition contains licorice extract.

[0097] In some embodiments, the soothing agent may be selected from natural extracts, including: Centella asiatica extract, Polygonum cuspidatum root extract, Scutellaria baicalensis root extract, Camellia japonica leaf extract, Glycyrrhiza uralensis root extract, Matricaria champaca flower extract, Rosmarinus officinalis leaf extract, Tea (Tea tree) leaf extract, Poria cocos extract, Caulis aubergine extract, lidocaine, Chia seed extract, Rosa rugosa flower extract, Aloe vera, allantoin, D-panthenol, turmeric, avocado oil, and lichen extract, or combinations of two or more thereof.

[0098] Based on the total weight of the personal care composition, the amount of one or more skin soothing agents in the personal care composition can be from about 0.01% by weight to about 7% by weight. In some cases, based on the total weight of the personal care composition, the personal care composition can be formulated to contain skin soothing agents in the following total amounts: about 0.01% by weight to about 5% by weight, about 0.01% by weight to about 3% by weight, about 0.01% by weight to about 2% by weight, about 0.01% by weight to about 1% by weight, about 0.01% by weight to about 0.75% by weight, about 0.01% by weight to about 0.5% by weight, about 0.01% by weight to about 0.25% by weight, about 0.01% by weight to about 0.1% by weight; about 0.05% by weight to about 7% by weight, about 0.05% by weight to about 5% by weight, about 0.05% by weight to about 3% by weight. Approximately 0.05 wt% to approximately 2 wt%, approximately 0.05 wt% to approximately 1 wt%, approximately 0.05 wt% to approximately 0.75 wt%, approximately 0.05 wt% to approximately 0.5 wt%, approximately 0.05 wt% to approximately 0.25 wt%, approximately 0.05 wt% to approximately 0.1 wt%; approximately 0.1 wt% to approximately 7 wt%, approximately 0.1 wt% to approximately 5 wt%, approximately 0.1 wt% to approximately 3 wt%, approximately 0.1 wt% to approximately 2 wt%, approximately 0.1 wt% to approximately 1 wt%, approximately 0.1 wt% to approximately 0.75 wt%, approximately 0.1 wt% to approximately 0.5 wt%, approximately 0.1 wt% to approximately 0.25 wt%; approximately 0.15 wt% to about 7 wt%, about 0.15 wt% to about 5 wt%, about 0.15 wt% to about 3 wt%, about 0.15 wt% to about 2 wt%, about 0.15 wt% to about 1 wt%, about 0.15 wt% to about 0.75 wt%, about 0.15 wt% to about 0.5 wt%, about 0.15 wt% to about 0.25 wt%; about 0.4 wt% to about 7 wt%, about 0.4 wt% to about 5 wt%, about 0.4 wt% to about 3 wt%, about 0.4 wt% to about 2 wt%, about 0.4 wt% to about 1 wt%, about 0.4 wt% to about 0.75 wt%; about 0.8 wt% to About 7 wt%, about 0.8 wt% to about 5 wt%, about 0.8 wt% to about 3 wt%, about 0.8 wt% to about 2 wt%, about 0.8 wt% to about 1 wt%; about 1.2 wt% to about 7 wt%, about 1.2 wt% to about 5 wt%, about 1.2 wt% to about 3 wt%, about 1.2 wt% to about 2 wt%; about 1.6 wt% to about 7 wt%, about 1.6 wt% to about 5 wt%, about 1.6 wt% to about 3 wt%, about 1.6 wt% to about 2 wt%; about 2 wt% to about 7 wt%, about 2 wt% to about 5 wt%, about 2 wt% to about 3 wt%, or any range or subrange thereof.

[0099] Personal care compositions may contain one or more moisturizers, for example, in amounts ranging from about 0.01 wt% to about 5 wt% based on the total weight of the personal care composition. For example, based on the total weight of the personal care composition, one or more moisturizers may be present in the following total amounts: about 0.01 wt% to about 4 wt%, about 0.01 wt% to about 3 wt%, about 0.01 wt% to about 2 wt%, about 0.01 wt% to about 1 wt%, about 0.01 wt% to about 0.75 wt%, about 0.01 wt% to about 0.5 wt%, about 0.01 wt% to about 0.25 wt%, about 0.01 wt% to about 0.1 wt%; about 0.05 wt% to about 5 wt%, about 0.05 wt% to about 3 wt%. Approximately 0.05 wt% to approximately 2 wt%, approximately 0.05 wt% to approximately 1 wt%, approximately 0.05 wt% to approximately 0.75 wt%, approximately 0.05 wt% to approximately 0.5 wt%, approximately 0.05 wt% to approximately 0.25 wt%, approximately 0.05 wt% to approximately 0.1 wt%; approximately 0.1 wt% to approximately 5 wt%, approximately 0.1 wt% to approximately 3 wt%, approximately 0.1 wt% to approximately 2 wt%, approximately 0.1 wt% to approximately 1 wt%, approximately 0.1 wt% to approximately 0.75 wt%, approximately 0.1 wt% to approximately 0.5 wt%, approximately 0.1 wt% % to about 0.25 wt%; about 0.15 wt% to about 5 wt%, about 0.15 wt% to about 3 wt%, about 0.15 wt% to about 2 wt%, about 0.15 wt% to about 1 wt%, about 0.15 wt% to about 0.75 wt%, about 0.15 wt% to about 0.5 wt%, about 0.15 wt% to about 0.25 wt%; about 0.4 wt% to about 5 wt%, about 0.4 wt% to about 3 wt%, about 0.4 wt% to about 2 wt%, about 0.4 wt% to about 1 wt%, about 0.4 wt% to about 0.75 wt%. ; about 0.5 wt%; about 0.8 wt% to about 5 wt%, about 0.8 wt% to about 3 wt%, about 0.8 wt% to about 2 wt%, about 0.8 wt% to about 1 wt%; about 1.2 wt% to about 5 wt%, about 1.2 wt% to about 3 wt%, about 1.2 wt% to about 2 wt%; about 1.6 wt% to about 5 wt%, about 1.6 wt% to about 3 wt%, about 1.6 wt% to about 2 wt%; about 2 wt% to about 7 wt%, about 2 wt% to about 5 wt%, about 2 wt% to about 3 wt%, or any range or subrange thereof.

[0100] Examples of moisturizers that can be incorporated into personal care compositions include, but are not limited to, polyols such as glycerin, saccharide isomers, butylene glycol, 1,3-propanediol, sorbitol, xylitol, or low molecular weight polyethylene glycol (PEG), polyoxyethylene, or combinations thereof. In some embodiments, the moisturizer is sorbitol (preferably, non-crystalline sorbitol), butylene glycol, 1,3-propanediol, glycerin (e.g., vegetable-refined glycerin), polyethylene glycol, or combinations thereof. In at least one embodiment, the moisturizer is selected from glycerin, butylene glycol, and 1,3-propanediol. Typically, the moisturizer is vegetable-refined glycerin. Other suitable moisturizers include, but are not limited to, polyglutamic acid, saccharide isomers, or combinations thereof. In at least one case, the moisturizer is a saccharide isomer. Saccharide isomers are commercially available, for example, from DSM under the trademark Pentavitin™. Other examples of humectants include glycerin and its derivatives, urea and its derivatives, sodium pidolate, xylitol, serine, sodium lactate, ectoin and its derivatives, chitosan and its derivatives, collagen, plankton, extracts of Imperata cylindra, beta-glucan, and / or rosehip oil.

[0101] In some embodiments, the personal care composition comprises a moisturizer selected from sorbitol, butylene glycol, 1,3-propanediol, glycerin, polyethylene glycol, polyglutamic acid, saccharide isomers, or combinations thereof. In some preferred embodiments, the personal care composition comprises saccharide isomers.

[0102] Personal care compositions may contain a carrier, such as water and / or a monohydric alcohol. For example, a personal care composition may contain a volatile monohydric alcohol. In some embodiments, the carrier may include ethanol, propanol, butanol, or combinations thereof. In at least one embodiment, the carrier comprises water. In another embodiment, the carrier is ethanol. In yet another embodiment, the carrier comprises ethanol and water.

[0103] In some embodiments, the amount of carrier in the personal care composition can range from about 0.01 wt% to about 7 wt% based on the total weight of the personal care composition. In some cases, the total amount of carrier present in the personal care composition can be from about 0.01 wt% to about 5 wt%, from about 0.01 wt% to about 3 wt%, from about 0.01 wt% to about 2 wt%, from about 0.01 wt% to about 1 wt%, from about 0.01 wt% to about 0.75 wt%, from about 0.01 wt% to about 0.5 wt%, from about 0.01 wt% to about 0.25 wt%, from about 0.01 wt% to about 0.1 wt%; from about 0.05 wt% to about 7 wt%, from about 0.05 wt% to about 5 wt%, from about 0.05 wt% to about 3 wt%, from about 0.05 wt% to about 7 wt%, from about 0.05 wt% to about 5 wt%, from about 0.05 wt% to about 3 wt%, from about 0.05 wt% to about 7 wt%. By weight % to about 2 wt%, about 0.05 wt% to about 1 wt%, about 0.05 wt% to about 0.75 wt%, about 0.05 wt% to about 0.5 wt%, about 0.05 wt% to about 0.25 wt%, about 0.05 wt% to about 0.1 wt%; about 0.1 wt% to about 7 wt%, about 0.1 wt% to about 5 wt%, about 0.1 wt% to about 3 wt%, about 0.1 wt% to about 2 wt%, about 0.1 wt% to about 1 wt%, about 0.1 wt% to about 0.75 wt%, about 0.1 wt% to about 0.5 wt%, about 0.1 wt% to about 0.25 wt%; about 0.15 By weight % to about 7 wt%, by weight % to about 5 wt%, by weight % to about 3 wt%, by weight % to about 2 wt%, by weight % to about 1 wt%, by weight % to about 0.15 wt%, by weight % to about 0.75 wt%, by weight % to about 0.5 wt%, by weight % to about 0.15 wt%, by weight % to about 0.25 wt%; by weight % to about 7 wt%, by weight % to about 5 wt%, by weight % to about 3 wt%, by weight % to about 2 wt%, by weight % to about 1 wt%, by weight % to about 0.75 wt%; by weight % to about 7 wt%. % by weight, about 0.8% by weight to about 5% by weight, about 0.8% by weight to about 3% by weight, about 0.8% by weight to about 2% by weight, about 0.8% by weight to about 1% by weight; about 1.2% by weight to about 7% by weight, about 1.2% by weight to about 5% by weight, about 1.2% by weight to about 3% by weight, about 1.2% by weight to about 2% by weight; about 1.6% by weight to about 7% by weight, about 1.6% by weight to about 5% by weight, about 1.6% by weight to about 3% by weight, about 1.6% by weight to about 2% by weight; about 2% by weight to about 7% by weight, about 2% by weight to about 5% by weight, about 2% by weight to about 3% by weight, or any range or subrange thereof.

[0104] Some embodiments of the present invention provide personal care compositions that are substantially free of or free of resorcinol. Further embodiments of the present invention provide personal care compositions that are substantially free of or free of hydroquinone. Still other embodiments provide personal care compositions that are substantially free of both resorcinol and hydroquinone.

[0105] In some embodiments, the personal care composition comprises a meroterpene, such as bakuchiol. In some embodiments, bakuchiol is present in an amount of about 0.1% to about 5% by weight, based on the total weight of the personal care composition. In some embodiments, bakuchiol is present in an amount of about 0.2% to about 4% by weight, based on the total weight of the personal care composition. In some embodiments, bakuchiol is present in an amount of about 0.3% to about 3.5% by weight, based on the total weight of the personal care composition. In some embodiments, bakuchiol is present in an amount of about 0.4% to about 3% by weight, based on the total weight of the personal care composition. In some embodiments, bakuchiol is present in an amount of about 0.5% to about 2.5% by weight, based on the total weight of the personal care composition. In some embodiments, bakuchiol is present in an amount of about 1% to about 2% by weight, based on the total weight of the personal care composition. In some cases, bakuchiol may be in the form of a salt.

[0106] In some embodiments, the personal care composition is in the form of one or more carriers in an amount ranging from about 25% to about 85% by weight based on the total weight of the personal care composition. For example, one or more carriers may be present in the personal care composition in the following amounts based on the total weight of the personal care composition: about 30% to about 85% by weight, about 35% to about 85% by weight, about 40% to about 85% by weight, about 45% to about 85% by weight, about 50% to about 85% by weight, about 55% to about 85% by weight, about 60% to about 85% by weight, about 65% to about 85% by weight, about 70% to about 85% by weight; about 25% to about 80% by weight, about 30% to about 85% by weight, about 30% to about 85% by weight, etc. 80 wt%, about 35 wt% to about 80 wt%, about 40 wt% to about 80 wt%, about 45 wt% to about 80 wt%, about 50 wt% to about 80 wt%, about 55 wt% to about 80 wt%, about 60 wt% to about 80 wt%, about 65 wt% to about 80 wt%; about 25 wt% to about 75 wt%, about 30 wt% to about 75 wt%, about 35 wt% to about 75 wt%, about 40 wt% to about 75 wt%, about 45 wt% to about 75 wt%, about 50 wt% to about 75 wt%, about 55 wt% % to about 75% by weight, about 60% by weight to about 75% by weight; about 25% by weight to about 70% by weight, about 30% by weight to about 70% by weight, about 35% by weight to about 70% by weight, about 40% by weight to about 70% by weight, about 45% by weight to about 70% by weight, about 50% by weight to about 70% by weight, about 55% by weight to about 70% by weight; about 25% by weight to about 65% by weight, about 30% by weight to about 65% by weight, about 35% by weight to about 65% by weight, about 40% by weight to about 65% by weight, about 45% by weight to about 65% by weight, about 50% by weight to about 65% by weight; about 25% by weight to about 60% by weight, about 30% by weight to about 60% by weight, about 35% by weight to about 60% by weight, about 40% by weight to about 60% by weight, about 45% by weight to about 60% by weight; about 25% by weight to about 55% by weight, about 30% by weight to about 55% by weight, about 35% by weight to about 55% by weight, about 40% by weight to about 55% by weight; about 25% by weight to about 50% by weight, about 30% by weight to about 50% by weight, about 35% by weight to about 50% by weight, or any range or subrange thereof.

[0107] In some embodiments, polyols and polyether derivatives may be used as solvents and / or surfactants in topical formulations. Suitable polyols and polyethers include propylene glycol, dipropylene glycol, polypropylene glycol 2000 and 4000, poly(ethylene oxide-copoly-propylene oxide) glycol, glycerol, sorbitol, ethoxylated sorbitol, hydroxypropyl sorbitol, polyethylene glycol 200 to 6000, methoxy polyethylene glycol 350, 550, 750, 2000 and 5000, polyethylene oxide homopolymers (100,000 to 5,000,000), polyalkylene glycols and derivatives, hexanediol, 2-methyl-2,4-pentanediol, 1,3-butanediol, 1,2,6-hexanetriol, 2-ethyl-1,3-hexanediol, vicinal diols having 15 to 18 carbon atoms, and polyoxypropylene derivatives of trimethylolpropane.

[0108] In some embodiments, the solvent may increase permeability by encapsulating polar pathways and / or by fluidizing lipids. Examples include water, alcohols (e.g., methanol and ethanol); alkyl methyl sulfoxides (e.g., dimethyl sulfoxide, alkyl homologues of methyl sulfoxide, dimethylacetamide, and dimethylformamide); pyrrolidones (e.g., 2-pyrrolidone, N-methyl-2-pyrrolidone); laurocapram (azone); and other solvents (e.g., propylene glycol, glycerol, organosilicon fluids, isopropyl palmitate).

[0109] In some implementations, surfactants can enhance polar pathway delivery, particularly for hydrophilic drugs. The ability of surfactants to alter permeation is a function of the polar head group and hydrocarbon chain length. Anionic surfactants include, but are not limited to, dioctyl sulfosuccinate, sodium lauryl sulfate, and decodecylmethylsulphoxide. Nonionic surfactants include, but are not limited to, Pluronic F127 and Pluronic F68. Bile salts include, but are not limited to, sodium ms taurocholate, sodium deoxycholate, and sodium tauroglycocholate. Others include, for example, propylene glycol-oleic acid and 1,4-butanediol-linoleic acid, urea, N,N-dimethyl-m-toluamide, calcium thioglycolate; anticholinergic agents, eucalyptol, di-O-methyl-β-cyclodextrin, and soy casein.

[0110] In other embodiments, polyol esters can be used as emulsifiers or emollients. Suitable polyol esters include ethylene glycol mono- and di-fatty acid esters, diethylene glycol mono- and di-fatty acid esters, polyethylene glycol (200 to 6000) mono- and di-fatty acid esters, propylene glycol mono- and di-fatty acid esters, polypropylene glycol 2000 monooleate, polypropylene glycol 2000 monostearate, ethoxylated propylene glycol monostearate, glyceryl mono- and di-fatty acid esters, polyglycerol polyfatty acid esters, ethoxylated glyceryl monostearate, 1,3-butanediol monostearate, 1,3-butanediol distearate, polyoxyethylene polyol fatty acid esters, sorbitol fatty acid esters, and polyoxyethylene sorbitol fatty acid esters.

[0111] Suitable emulsifiers for topical formulations include anionic surfactants, cationic surfactants, nonionic surfactants, and amphoteric surfactants. Preferred ionic emulsifiers include phospholipids, such as lecithin and its derivatives. Lecithin and other phospholipids can be used to prepare liposomes comprising peptide compositions as described herein. Lipid vesicles form when phospholipids, such as lecithin, are placed in water and subsequently, upon supplying sufficient energy, form a bilayer or a series of bilayers (separated by individual water molecules). Liposomes can be produced by sonicating phospholipids in water. Low shear rates produce multilayered liposomes. Sustained high-shear sonication tends to form smaller monolayer liposomes. Hydrophobic chemicals can dissolve into the phospholipid bilayer membrane. The lipid bilayer of liposomes delivers peptide compositions as described herein.

[0112] The personal care compositions described herein may comprise micelles, or aggregates of surfactant molecules dispersed in an aqueous solution. Micelles can be prepared by dispersing an oil solvent in an aqueous solution containing a surfactant, wherein the surfactant concentration exceeds a critical micelle concentration. The resulting formulation comprises micelles, i.e., spherical oil droplets surrounded by a film of polar surfactant molecules dispersed in an aqueous solvent.

[0113] Sterols (including, for example, cholesterol and cholesterol fatty acid esters); amides (such as fatty acid amides, ethoxylated fatty acid amides and fatty acid alkanolamides) can also be used as emollients and / or penetration enhancers.

[0114] In some embodiments, the pH of the personal care composition described herein is from about 2.0 to about 4.5. In other embodiments, the pH of the personal care composition described herein is from about 2.1 to about 4.4. In other embodiments, the pH of the personal care composition described herein is from about 2.2 to about 4.3. In some embodiments, the pH of the personal care composition described herein is from about 2.3 to about 4.2. In some embodiments, the pH of the personal care composition described herein is from about 2.4 to about 4.1. In other embodiments, the pH of the personal care composition described herein is from about 2.5 to about 4.0. In some embodiments, the pH of the personal care composition described herein is from about 2.6 to about 3.9. In other embodiments, the pH of the personal care composition described herein is from about 2.7 to about 3.8. In other embodiments, the pH of the personal care composition described herein is from about 2.8 to about 3.7. In some embodiments, the pH of the personal care composition described herein is from about 2.9 to about 3.6. In some embodiments, the pH of the personal care composition described herein is from about 3.0 to about 3.5. In some embodiments, the pH of the personal care composition described herein is from about 2.1 to about 4.1. In some other embodiments, the pH of the personal care composition described herein is from about 3.1 to about 4.1. In some embodiments, the pH of the personal care composition is about 2.0, about 2.1, about 2.2, about 2.3, about 2.4, about 2.5, about 2.6, about 2.7, about 2.8, about 2.9, about 3.0, about 3.1, about 3.2, about 3.3, about 3.4, about 3.5, about 3.6, about 3.7, about 3.8, about 3.9, about 4.0, about 4.1, about 4.2, about 4.3, about 4.4, or about 4.5.

[0115] Example

[0116] Example 1

[0117] Non-limiting example personal care compositions (Example 1) were prepared according to aspects of the present invention. The formulation of Example 1 is shown in Table 1 (below).

[0118] Table 1

[0119]

[0120] Example 2

[0121] A second non-limiting example personal care composition (Example 2) was prepared according to an aspect of the invention. The formulation of Example 2 is shown in Table 1 (below).

[0122] Table 2

[0123]

[0124] Example 3

[0125] An in vitro evaluation of Example 1 was performed to assess the effect of such a skin care composition on the expression of TGFB2, VEGF, and AQP3 (biomarkers associated with improved regeneration and healing). Specifically, Example 1 was applied to skin care products containing EpiDerm. TM Samples of keratinocytes were provided and incubated for 24 or 48 hours. Control samples were prepared by following the same steps but without applying the methods described in Example 1.

[0126] In addition, Example 1 was applied to a skin explant sample obtained from a 37-year-old female volunteer with Fitzpatrick skin type V. The skin explant sample was then incubated for 6 days. A control sample was prepared by following the same procedure but without applying Example 1.

[0127] Keratinocyte and skin explant samples were evaluated, and the results are summarized as follows: Figure 1 and Figure 2 Based on these results, it was determined that Example 1 promoted the desired regulation of biomarkers associated with skin cell regeneration and wound healing, which were impaired in acne lesions.

[0128] Example 4

[0129] An in vivo evaluation of Example 1 was conducted to assess the effectiveness of such a skin care composition over an eight-week period. Specifically, five volunteers were instructed to apply Example 1 to their skin areas after rinsing and patting dry twice. The volunteers were then instructed to apply the provided moisturizer and provided sunscreen to the same skin area. The skin area was evaluated to assess sebum levels, erythema index, texture count, and pore size. Figure 3 The summary of sebum levels, erythema index, texture count, and pore size is shown before and after the completion of the eight-week application period of Example 1. Based on the results, Example 1 was determined to be effective in reducing acne lesions characterized by sebum, pores, uneven texture, and redness.

[0130] This disclosure has been described with reference to exemplary embodiments. While a limited number of embodiments have been shown and described, those skilled in the art will understand that changes can be made to these embodiments without departing from the principles and spirit of the foregoing embodiments. This disclosure is intended to be construed as including all such modifications and changes, provided they fall within the scope of the appended claims or their equivalents.

Claims

1. A personal care composition comprising: Adapalene oil ester; β-hydroxy acids and / or their salts; and Moisturizer.

2. The personal care composition of claim 1, wherein the β-hydroxy acid and / or its salt comprises salicylic acid, β-hydroxybutyric acid, scopolamine, trasococcal acid, its salt, or a combination of two or more thereof.

3. The personal care composition according to claim 1 or claim 2, wherein the β-hydroxy acid and / or its salt comprises salicylic acid, its salt, or a combination thereof.

4. The personal care composition according to any of the preceding claims, wherein the β-hydroxy acid and / or its salt are present in an amount of about 5% to about 25% by weight, based on the total weight of the personal care composition.

5. The personal care composition according to any of the preceding claims further comprises an α-hydroxy acid and / or a salt thereof.

6. The personal care composition of claim 5, wherein the α-hydroxy acid and / or its salt comprises mandelic acid, lactic acid, malic acid, tartaric acid, phytic acid, its salt, or a combination of two or more thereof.

7. The personal care composition according to claim 5 or claim 6, wherein the α-hydroxy acid and / or its salt are present in an amount ranging from about 5% by weight to about 25% by weight, based on the total weight of the personal care composition.

8. The personal care composition according to any of the preceding claims further comprises an anti-acne agent selected from: keratolytic agents, retinoids, retinoic acid, adapalene, tazarotene, lipoic acid, benzoyl peroxide, chlorhexidine gluconate, piroctone olamine salt, tetracycline, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 3,4,4'-trichlorocarbonylaniline, nicotinamide, tea tree oil, rofecoxib, azelaic acid and its derivatives. The following substances, including phenoxyethanol, phenoxypropanol, phenoxyisopropanol, ethyl acetate, clindamycin, erythromycin, meclocycline, sebostats, minocycline, moxifloxacin, N-acetylcysteine, naflufloxacin, piroctone ethanolamine salt, prulifloxacin, sitafloxacin, sodium sulfacetamide, spironolactone, sulfacetamide, sulfur, tazarotene, retinoic acid, eufloxacin, metronidazole, ornidazole, urea, and combinations thereof.

9. The personal care composition according to any of the preceding claims further comprises an antioxidant selected from: camellia extract, quercetin, green tea, soybean, milk thistle, algae, aloe vera, angelica, bitter orange, coffee, coptis, grapefruit, scutellaria, honeysuckle, coix seed, gromwell root, mulberry, peony, kudzu, rice, safflower, and combinations of two or more thereof.

10. The personal care composition according to any of the preceding claims, wherein the moisturizer is selected from sorbitol, butylene glycol, 1,3-propanediol, glycerin, polyethylene glycol, polyglutamic acid, saccharide isomers, and combinations thereof or more.

11. The personal care composition of claim 10, wherein the moisturizer is present in an amount of about 0.01% by weight to about 5% by weight, based on the total weight of the personal care composition.

12. The personal care composition according to any of the preceding claims further comprises licorice extract.

13. A personal care composition comprising: Adapalene oil ester; α-hydroxy acids and / or their salts; Lipoic acid and / or its salts; and Carbohydrate isomers.

14. The personal care composition of claim 13, wherein the α-hydroxy acid and / or its salt is selected from mandelic acid, lactic acid, malic acid, tartaric acid, phytic acid, its salts, and combinations of two or more thereof.

15. The personal care composition of claim 14 further comprises a β-hydroxy acid and / or a salt thereof, said β-hydroxy acid and / or a salt thereof selected from salicylic acid, β-hydroxybutyric acid, scopolamine, trosococcal acid, their salts, and combinations of two or more thereof.

16. The personal care composition of claim 14, further comprising licorice extract.

17. A personal care composition comprising: retinoids; psoralen; α-hydroxy acids or their salts; and A carrier acceptable for cosmetics.

18. The personal care composition of claim 17, wherein the α-hydroxy acid or a salt thereof is selected from mandelic acid, lactic acid, malic acid, tartaric acid, phytic acid, their salts, and combinations thereof.

19. The personal care composition of claim 17 or claim 18, wherein the retinoid comprises adapalene oleyl ester or a derivative thereof.

20. The personal care composition according to any of the preceding claims, wherein the pH of the personal care composition is from about 2.5 to about 4.5.

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