Rehmannia neutral homogeneous polysaccharide as well as preparation method and application thereof

By using neutral homogeneous polysaccharides from Rehmannia glutinosa as a growth scaffold for bone mesenchymal stem cells (BMSCs), the problems of low survival rate and suppressed osteogenic differentiation potential after BMSC transplantation have been solved, achieving effective treatment for osteoporosis and bone defects and providing a highly efficient and safe treatment strategy for bone metabolic diseases.

CN121319232AActive Publication Date: 2026-01-13CHINA PHARM UNIV
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Patent Information

Application Number
CN202511533471.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-10-24
Publication Date
2026-01-13
Estimated Expiration
2045-10-24

AI Technical Summary

Technical Problem

Existing bone marrow mesenchymal stem cells (BMSCs) have low survival rates after transplantation, are susceptible to immune rejection, and have suppressed osteogenic differentiation potential. Traditional bone repair strategies have limitations and cannot achieve perfect structural and functional reconstruction of bone defects.

Method used

Using Rehmannia glutinosa neutral homogeneous polysaccharide as an in vivo delivery and growth scaffold for BMSCs, we can induce their directional differentiation through specific microenvironment signals, promote osteogenic differentiation, and improve bone mineralization and bone density through Rehmannia glutinosa neutral polysaccharide to prepare osteoporosis drugs.

Benefits of technology

Neutral homogeneous polysaccharides from Rehmannia glutinosa improve the survival rate and osteogenic differentiation potential of BMSCs, promote the proliferation and directed osteogenic differentiation of bone marrow mesenchymal stem cells, effectively treat osteoporosis and bone defects, and provide an efficient and safe treatment strategy for bone metabolic diseases.

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Abstract

The invention discloses a rehmannia neutral homogeneous polysaccharide as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine preparations. The polysaccharide mainly comprises galactose, glucose and fructose, the molar ratio of the galactose to the glucose to the fructose is 2.72: 1.17: 1.11, and the weight-average molecular weight of the polysaccharide is 2152 Da. The rehmannia neutral polysaccharide can play a role in treating osteoporosis by increasing bone mineralization amount and bone mineral density; the proliferation and directional osteogenic differentiation of the bone marrow mesenchymal stem cells BMSCs can be promoted, and the obvious application effect is achieved in the aspect of preparing the bone defect treatment medicine through the stem cells. The rehmannia neutral homogeneous polysaccharide shows a huge application prospect in the aspects of preparation of medicines for treating osteoporosis and stem cell treatment (especially bone regeneration treatment based on mesenchymal stem cells). A new candidate substance and a research direction are provided for developing an efficient and safe bone metabolism disease treatment strategy derived from traditional Chinese medicines.
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