Auxiliary treatment device for neuronal ferroptosis in cerebral ischemia-reperfusion injury

Abstract

The invention relates to an auxiliary treatment device for neuronal ferroptosis in cerebral ischemia reperfusion injury, the auxiliary treatment device comprises a shell worn on the head of a patient and an ischemia adaptation assembly wound on four limbs of the patient, the inner side of the shell is fixedly connected with a first air bag, the first air bag is communicated with a first air delivery pipe, and the first air delivery pipe is communicated with a second air delivery pipe; the first air conveying pipe is communicated with a first electromagnetic valve, the end, away from the first air bag, of the first air conveying pipe is communicated with an air pump, and the first air bag is communicated with a first pressure release valve. The invention aims to solve the problem of side effects possibly caused by non-specific distribution of drugs in the prior art.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to an auxiliary treatment device for neuron ferroptosis in cerebral ischemia-reperfusion injury. BACKGROUND

[0002] Cerebral ischemia-reperfusion injury is a pathological phenomenon that occurs in ischemic stroke patients after receiving vascular recanalization therapy (such as intravenous thrombolysis and arterial thrombectomy), in which blood flow recovery exacerbates brain tissue damage. This process not only fails to reverse the cell damage during ischemia, but also activates a more complex cascade reaction, leading to blood-brain barrier damage, oxidative stress explosion, inflammation activation, and ultimately programmed cell death, which severely restricts the clinical benefits of vascular recanalization therapy.

[0003] In recent years, studies have shown that neuron ferroptosis plays a key role in the core mechanism of cerebral ischemia-reperfusion injury. Ferroptosis is a new type of programmed cell death dependent on iron ions, which is different from apoptosis (programmed death), necrosis (non-programmed death), and autophagy. Its core molecular mechanism involves the loss of glutathione peroxidase 4 activity, leading to the accumulation of intracellular lipid peroxides that cannot be cleared in time. Under the background of cerebral ischemia-reperfusion, ischemia and hypoxia can trigger metabolic disorders, free radical explosions, and free iron release, which together constitute a "perfect storm" of ferroptosis, ultimately leading to irreversible membrane structural damage and death of neurons through the toxic effects of lipid peroxides.

[0004] Based on the above mechanism, current neuroprotective strategies targeting ferroptosis mainly rely on pharmacological intervention, aiming to interrupt the ferroptosis pathway at different nodes: Iron chelators: such as deferoxamine, which chelates free iron and reduces the catalytic substrate of the Fenton reaction.

[0005] Lipophilic antioxidants: such as Ferrostatin-1 and Liproxstatin-1, which can efficiently neutralize lipid free radicals and interrupt the chain reaction of lipid peroxidation.

[0006] GPX4 agonists / supplements: aimed at restoring or enhancing the activity of GPX4, fundamentally improving the cell's ability to clear lipid peroxides.

[0007] However, non-specific distribution of drugs can lead to side effects. For example, systemic iron chelation can cause anemia, hypotension, and systemic iron metabolism disorders; some antioxidants or their metabolites can increase the burden on the liver and kidneys. SUMMARY

[0008] Therefore, the application aims to provide an auxiliary treatment device for neuronal ferroptosis in cerebral ischemia-reperfusion injury to solve the problem of side effects caused by non-specific distribution of existing drugs.

[0009] The application is realized by the following technical scheme: An auxiliary treatment device for neuronal ferroptosis in cerebral ischemia-reperfusion injury, comprising a shell worn on the head of a patient and an ischemia adaptation component wrapped around the limbs of the patient, a first air bag is fixedly connected to the inner side of the shell, a first gas delivery pipe is communicated with the first air bag, a first electromagnetic valve is communicated with the first gas delivery pipe, a gas pump is communicated with the end of the first gas delivery pipe away from the first air bag, and a first pressure relief valve is communicated with the first air bag.

[0010] Further, the ischemia adaptation component comprises a plurality of straps, and the plurality of straps are respectively wrapped around the limbs of the patient.

[0011] Further, the two ends of each of the plurality of straps are fixedly connected with a Velcro hook surface and a Velcro loop surface, and the Velcro hook surface of each of the plurality of straps is respectively pasted on the corresponding Velcro loop surface.

[0012] Further, a second air bag is fixedly connected to each of the plurality of straps for pasting on one side of the patient, a second pressure relief valve is communicated with each of the plurality of second air bags, a second gas delivery pipe is communicated with each of the plurality of second air bags, a second electromagnetic valve is communicated with each of the plurality of second gas delivery pipes, and the end of each of the plurality of second gas delivery pipes away from the corresponding second air bag is communicated with the gas pump.

[0013] Further, a cooling box is communicated with the side of the gas pump away from the first gas delivery pipe, and a semiconductor refrigeration sheet is fixedly connected in the cooling box.

[0014] Further, an electric circuit board is also fixedly connected to the inner side of the shell, a plurality of near-infrared LED lamp beads are electrically connected to the electric circuit board, and the plurality of near-infrared LED lamp beads are uniformly distributed along the length direction of the electric circuit board.

[0015] Further, the number of the first air bags and the electric circuit boards is a plurality, the plurality of first air bags and the plurality of electric circuit boards are arranged at intervals on the inner side of the shell, and the plurality of first air bags are communicated with the first gas delivery pipe.

[0016] Further, a chin strap is fixedly connected to the shell, and an adjusting buckle is installed on the chin strap.

[0017] Further, a temperature sensor is installed on the first air bag, and the temperature sensor is pasted on the scalp of the patient.

[0018] Further, a pressure sensor is installed on the first air bag, and the pressure sensor is pasted on the scalp of the patient.

[0019] The beneficial effects of the present application are: The auxiliary treatment device for neuron ferroptosis in cerebral ischemia-reperfusion injury is characterized in that the patient wears the shell, the first air bag is fixed to the scalp by the lower jaw belt and the adjusting buckle, the second air bag is fixed to the skin by winding the bandage on the limbs and using the magic tape hook surface and the magic tape wool surface, the first electromagnetic valve controls the inflation cycle of the first air bag and the first pressure relief valve controls the deflation cycle of the first air bag to perform intermittent pressure treatment on the head, the first air bag is in a sub-hypothermia state to reduce the cerebral metabolic rate, inhibit oxidative stress and inflammatory factor release and reduce ferroptosis-related lipid peroxidation reaction, the second electromagnetic valve controls the inflation cycle of the second air bag and the second pressure relief valve controls the deflation cycle of the second air bag to perform intermittent compression on the limbs, non-drug intervention is provided to reduce pharmacological side effects (such as anemia caused by iron chelators or the burden on the liver and kidneys of antioxidants), the sidewall of the air bag is cooled by natural wind to reduce the cerebral metabolic rate, inhibit oxidative stress and inflammatory factor release and reduce ferroptosis-related lipid peroxidation reaction, and the endogenous neuroprotective pathway is activated by remote ischemic conditioning to reduce the occurrence of neuron ferroptosis and improve the prognosis of cerebral ischemia-reperfusion injury.

[0020] Additional advantages, objects, and features of the application will be set forth in part by the description that follows, and in part will become apparent to those skilled in the art upon examination of the following specification or can be learned from practice of the application. The objects and other advantages of the application can be realized and attained by the structure particularly pointed out in the specification. BRIEF DESCRIPTION OF DRAWINGS

[0021] Figure 1 Use of the application Figure 1 ; Figure 2 Use of the application Figure 1 ; Figure 3 Use of the application Figure 2 ; Figure 4 Structure of the application Figure 5 Connection of the cooling box and the air pump of the application Figure 6 Connection of the shell and the first electromagnetic valve and the first pressure relief valve of the application Figure 7 Connection of the shell and the lower jaw belt of the application Figure 8 Use of the application Figure 7A local enlarged view at B; Figure 9 For the present invention Figure 7 A local enlarged view at C; Figure 10 A local structure schematic view for the present invention; In the figure: 1, shell; 2, ischemia adaptation assembly; 3, first air bag; 4, first air pipe; 5, first electromagnetic valve; 6, air pump; 7, first pressure relief valve; 8, bandage; 9, magic tape hook surface; 10, magic tape hair surface; 11, second air bag; 12, second pressure relief valve; 13, second air pipe; 14, second electromagnetic valve; 15, cooling box; 16, semiconductor refrigeration piece; 17, circuit board; 18, near-infrared LED lamp bead; 19, lower jaw band; 20, adjusting buckle; 21, temperature sensor; 22, pressure sensor. DETAILED DESCRIPTION

[0022] In order to make the purpose, technical scheme and advantages of the embodiments of the present application clearer, the technical scheme in the embodiments of the present application will be described clearly and completely below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, rather than all the embodiments. The components of the embodiments of the present application described and shown in the drawings can be arranged and designed in various different configurations.

[0023] Therefore, the following detailed description of the embodiments of the present application provided in the drawings is not intended to limit the scope of the claimed application, but only represents selected embodiments of the present application. All other embodiments obtained by those of ordinary skill in the art based on the embodiments in the present application without creative labor are within the scope of protection of the present application.

[0024] It should be noted that: similar numbers and letters represent similar items in the following drawings, therefore, once an item is defined in one drawing, it does not need to be further defined and explained in subsequent drawings.

[0025] In the above description of the present application, it should be noted that the terms "one side", "the other side" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, or the orientation or positional relationship when the product of the present application is usually placed, which is only for the convenience of describing the present application and simplifying the description, and does not indicate or imply that the indicated device or element must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application. In addition, the terms "first", "second" and the like are only used to distinguish the description and cannot be understood as indicating or implying relative importance.

[0026] In addition, the term "same" and the like do not mean that the components are absolutely the same, but there can be slight differences. The term "vertical" only means that the positional relationship between the components is more vertical than "parallel", and does not mean that the structure must be completely vertical, but can be slightly inclined.

[0027] Please refer to Figures 1-10 The application provides a technical scheme: an auxiliary treatment device for neuron ferroptosis in cerebral ischemia-reperfusion injury, which comprises a shell 1 worn on the head of a patient and an ischemia adaptation assembly 2 wound around the limbs of the patient, a first air bag 3 is fixedly connected to the inner side of the shell 1, a first gas conveying pipe 4 is communicated with the first air bag 3, a first electromagnetic valve 5 is communicated with the first gas conveying pipe 4, a gas pump 6 is communicated with one end of the first gas conveying pipe 4 away from the first air bag 3, and a first pressure relief valve 7 is communicated with the first air bag 3.

[0028] The ischemia adaptation assembly 2 comprises a plurality of binding belts 8, and the plurality of binding belts 8 are wound around the limbs of the patient respectively.

[0029] Two ends of each of the plurality of binding belts 8 are fixedly connected with a Velcro hook surface 9 and a Velcro loop surface 10 respectively, and the plurality of Velcro hook surfaces 9 are pasted on the corresponding Velcro loop surfaces 10 respectively.

[0030] A second air bag 11 is fixedly connected to each of the plurality of binding belts 8 for pasting on one side of the patient, a second pressure relief valve 12 is communicated with each of the plurality of second air bags 11, a second gas conveying pipe 13 is communicated with each of the plurality of second air bags 11, a second electromagnetic valve 14 is communicated with each of the plurality of second gas conveying pipes 13, and one end of each of the plurality of second gas conveying pipes 13 away from the corresponding second air bag 11 is communicated with the gas pump 6.

[0031] A chin strap 19 is fixedly connected to the shell 1, and an adjusting buckle 20 is installed on the chin strap 19.

[0032] A temperature sensor 21 is installed on the first air bag 3, and the temperature sensor 21 is pasted on the scalp of the patient.

[0033] A pressure sensor 22 is installed on the first air bag 3, and the pressure sensor 22 is pasted on the scalp of the patient.

[0034] A controller is further included, and the controller is electrically connected with the gas pump 6, the first electromagnetic valve 5, the first pressure relief valve 7, the second pressure relief valve 12, the second electromagnetic valve 14, the temperature sensor 21 and the pressure sensor 22.

[0035] Working principle: the first air bag 3 is inflated by the air pump 6 to apply controllable pressure to the scalp, adjust the cerebral blood flow and intracranial pressure, reduce oxidative stress and inflammatory response during reperfusion. And the side wall of the air bag is cooled by natural wind, which can reduce brain metabolic rate, inhibit oxidative stress and inflammatory factor release, thereby reducing iron death related lipid peroxidation reaction.

[0036] The second air bag 11 intermittently compresses the limbs to simulate ischemic preconditioning or postconditioning, trigger endogenous protective mechanisms (such as release of neurohumoral factors), improve the tolerance of neurons to ischemia, and thereby inhibit the key pathways of ferroptosis (such as reducing free iron release and lipid peroxide production).

[0037] The magic tape hook surface 9 and the magic tape hair surface 10 are respectively fixed on both ends of the bandage 8, which facilitates the fixation of multiple bandages 8 on the limbs of the patient. The magic tape hook surface 9 and the magic tape hair surface 10 have been softened by existing technology to reduce discomfort when they come into contact with the human skin.

[0038] The lower jaw strap 19 is fixed on the shell 1, and the adjusting buckle 20 is installed on the lower jaw strap 19, which makes the shell 1 more firmly fixed on the head of the patient.

[0039] The temperature sensor 21 and the pressure sensor 22 are used to monitor the scalp condition and reduce the risk of excessive compression or abnormal temperature.

[0040] The transmission connection mode of the above-mentioned electrical components mentioned in the technical solution of the present application is as follows: The signal output end of the temperature sensor 21 and the pressure sensor 22 is electrically connected with the signal input end of the controller, and the signal output end of the controller is electrically connected with the signal input end of the air pump 6, the first electromagnetic valve 5, the first pressure relief valve 7, the second pressure relief valve 12 and the second electromagnetic valve 14.

[0041] Therefore, the temperature sensor 21 and the pressure sensor 22 can transmit the temperature and pressure information to the controller through wired connection or wireless connection such as Wi-Fi module, and the controller can pre-process and encode the electrical signal and then transmit the electrical signal of the next action to the air pump 6, the first electromagnetic valve 5, the first pressure relief valve 7, the second pressure relief valve 12 and the second electromagnetic valve 14. As for the above-mentioned wired connection mode and / or wireless connection mode, they are one of the existing technologies in the field, and the skilled person in the art can implement and reproduce the connection and signal transmission of the above-mentioned electrical components based on the existing technology and the content recorded in the present application without creative labor and thinking.

[0042] Use method: Step one: the patient wears the shell 1, and the first air bag 3 is fixed with the scalp by the lower jaw belt 19 and the adjusting buckle 20.

[0043] Step two: the bandage 8 is wrapped around the limbs, and the second air bag 11 is in contact with the skin by using the magic tape hook surface 9 and the magic tape hair surface 10.

[0044] Step three: the air pump 6 is started by the controller, and the first electromagnetic valve 5 controls the inflation cycle of the first air bag 3 and the first pressure relief valve 7 controls the deflation cycle of the first air bag 3, and the head is subjected to intermittent pressure treatment.

[0045] And through the contact of the first air bag 3 with the scalp, it is in a sub-low temperature state, thereby reducing the brain metabolic rate, inhibiting oxidative stress and inflammatory factor release, and thereby reducing iron death related lipid peroxidation reaction.

[0046] At the same time, the second air bag 11 is controlled by the second electromagnetic valve 14 to control the inflation cycle, and the second pressure relief valve 12 controls the deflation cycle of the second air bag 11, and the limbs are subjected to intermittent compression (for example, inflation for 5 minutes, deflation for 5 minutes, and repeated multiple times).

[0047] Technical effect: non-drug intervention is provided, and the pharmacological side effects (such as anemia caused by iron chelators or the burden on liver and kidney of antioxidants) are reduced. By natural wind cooling the side wall of the air bag, the brain metabolic rate can be reduced, the oxidative stress and inflammatory factor release can be inhibited, and the iron death related lipid peroxidation reaction can be reduced. And by remote ischemic preconditioning, the endogenous neuroprotective pathway is activated, the occurrence of neuronal iron death is reduced, and the prognosis of cerebral ischemia-reperfusion injury is improved.

[0048] In this embodiment: the air pump 6 is connected with a cooling box 15 away from one side of the first air pipe 4, and the cooling box 15 is fixedly connected with a semiconductor refrigerating sheet 16. The semiconductor refrigerating sheet 16 is electrically connected with the controller.

[0049] Working principle: the semiconductor refrigerating sheet 16 in the cooling box 15 is used to actively cool the air, and the air pump 6 sends the cooled air into the first air bag 3 and the second air bag 11 through the first air pipe 4, realizing local cooling of the head and limbs, and improving the cooling effect compared with natural wind. Low temperature can reduce the brain metabolic rate, inhibit oxidative stress and inflammatory factor release, and thereby reduce iron death related lipid peroxidation reaction.

[0050] In this embodiment: the inner side of the shell 1 is also fixedly connected with a circuit board 17, and the circuit board 17 is electrically connected with a plurality of near-infrared LED lamp beads 18, and the plurality of near-infrared LED lamp beads 18 are uniformly distributed along the length direction of the circuit board 17.

[0051] The first air bags 3 and the circuit boards 17 are both multiple in number, and the multiple first air bags 3 and the multiple circuit boards 17 are arranged at intervals on the inner side of the shell 1, and the multiple first air bags 3 are all communicated with the first gas conveying pipe 4.

[0052] Working principle: The near-infrared LED lamp bead 18 emits photons of a specific wavelength (such as 808nm), which penetrates the scalp and skull and acts on the brain tissue. Near-infrared light can activate mitochondrial cytochrome c oxidase, enhance ATP synthesis, improve energy metabolism, reduce the generation of reactive oxygen species (ROS) and inhibit inflammatory response, thereby blocking the key link of ferroptosis (such as lipid peroxidation chain reaction). The circuit board 17 makes the near-infrared LED lamp bead 18 evenly distributed, and cooperates with the first air bag 3 to realize multi-mode synchronous treatment.

[0053] Finally, it should be pointed out that the above embodiments are only used to illustrate the technical solutions of the present application and are not limiting. Although the present application has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that the technical solutions of the present application can be modified or replaced by equivalents without departing from the purpose and scope of the present application, and they should be covered in the scope of the claims of the present application.

Claims

1. An adjunctive therapy device for neuronal ferroptosis in cerebral ischemia-reperfusion injury, characterized in that: The application relates to a wearable ischemia adaptation device, which comprises a shell (1) worn on the head of a patient and an ischemia adaptation component (2) wound around the limbs of the patient, the inner side of the shell (1) is fixedly connected with a first air bag (3), the first air bag (3) is communicated with a first gas conveying pipe (4), the first gas conveying pipe (4) is communicated with a first electromagnetic valve (5), the end of the first gas conveying pipe (4) away from the first air bag (3) is communicated with a gas pump (6), and the first air bag (3) is communicated with a first pressure relief valve (7).

2. The device for adjunctive therapy of neuronal ferroptosis in cerebral ischemia-reperfusion injury according to claim 1, characterized in that: The ischemia adaptation component (2) comprises a plurality of binding belts (8) which are wound around the limbs of the patient.

3. The device for adjunctive therapy of neuronal ferroptosis in cerebral ischemia-reperfusion injury according to claim 2, characterized in that: The two ends of the plurality of binding belts (8) are fixedly connected with a Velcro hook surface (9) and a Velcro loop surface (10) respectively, and the plurality of Velcro hook surfaces (9) are pasted on the corresponding Velcro loop surfaces (10) respectively.

4. The device for adjunctive therapy of ferroptosis in neurons in cerebral ischemia-reperfusion injury according to claim 2, characterized in that: The plurality of binding belts (8) are fixedly connected with a second air bag (11) on the side for pasting the patient, the plurality of second air bags (11) are communicated with a second pressure relief valve (12), the plurality of second air bags (11) are communicated with a second gas conveying pipe (13), the plurality of second gas conveying pipes (13) are communicated with a second electromagnetic valve (14), and the ends of the plurality of second gas conveying pipes (13) away from the corresponding second air bags (11) are communicated with the gas pump (6).

5. The device for adjunctive therapy of ferroptosis in neurons in cerebral ischemia-reperfusion injury according to claim 1, characterized in that: The side of the gas pump (6) away from the first gas conveying pipe (4) is communicated with a cooling box (15), and the cooling box (15) is fixedly connected with a semiconductor refrigerating sheet (16) inside.

6. The device for adjunctive therapy of neuronal ferroptosis in cerebral ischemia-reperfusion injury according to claim 1, characterized in that: The inner side of the shell (1) is further fixedly connected with a circuit board (17), the circuit board (17) is electrically connected with a plurality of near-infrared LED lamp beads (18), and the plurality of near-infrared LED lamp beads (18) are uniformly distributed along the length direction of the circuit board (17).

7. The device for the adjunctive treatment of neuronal ferroptosis in cerebral ischemia-reperfusion injury according to claim 6, characterized in that: The number of the first air bags (3) and the circuit board (17) is multiple, the plurality of first air bags (3) and the plurality of circuit boards (17) are arranged at intervals on the inner side of the shell (1), and the plurality of first air bags (3) are communicated with the first gas conveying pipe (4).

8. The device for adjunctive therapy of ferroptosis in neurons in cerebral ischemia-reperfusion injury according to claim 1, characterized in that: The shell (1) is fixedly connected with a chin strap (19), and the chin strap (19) is installed with an adjusting buckle (20).

9. The device for adjunctive therapy of ferroptosis in neurons in cerebral ischemia-reperfusion injury according to claim 1, characterized in that: The first air bag (3) is installed with a temperature sensor (21), and the temperature sensor (21) is pasted on the scalp of the patient.

10. The device for adjunctive therapy of ferroptosis in neurons in cerebral ischemia-reperfusion injury according to claim 1, characterized in that: The first air bag (3) is installed with a pressure sensor (22), and the pressure sensor (22) is pasted on the scalp of the patient.

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