Cornea surface protective agent and preparation method thereof

By combining chitosan quaternary ammonium salt, trehalose, and recombinant human collagen in a specific ratio, a corneal surface protectant is formed, which solves the problems of insufficient long-term moisturizing and tissue repair in existing technologies. This enables rapid corneal film formation, long-term moisturizing, and promotion of epithelial repair, thereby improving surgical results and patient comfort.

CN121371133APending Publication Date: 2026-01-23青岛中科蓝智生物科技发展有限公司
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Patent Information

Application Number
CN202511696831.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-11-19
Publication Date
2026-01-23

AI Technical Summary

Technical Problem

Existing corneal protectants are insufficient in terms of long-lasting moisturizing, rapid film formation, and promotion of tissue repair, and cannot meet the stringent requirements for transparency, adhesion, and biocompatibility in ophthalmic surgery.

Method used

A specific combination of chitosan quaternary ammonium salt, trehalose, and recombinant human collagen, along with Tris-HCl buffer, forms a corneal surface protectant that rapidly forms a film, provides long-lasting hydration, and promotes epithelial repair.

Benefits of technology

It forms a uniform, stable, and highly transparent protective film on the corneal surface, providing long-lasting moisturizing effects, promoting corneal epithelial repair, reducing the risk of postoperative complications, and improving surgical efficiency and patient comfort.

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Abstract

The invention relates to the technical field of medical supplies for ophthalmology, and particularly discloses a cornea surface protective agent based on a compound polysaccharide synergistic effect and a preparation method of the cornea surface protective agent. The protective agent comprises chitosan quaternary ammonium salt, trehalose and recombinant human collagen as core active components, and a specific buffer system is supplemented. Through the specific proportioning combination of the core components, the protective agent can quickly form a stable and light-transmitting protective film on the cornea surface, and provides the comprehensive effects of long-acting moisturizing, epithelial repair promotion and inflammation resistance. Experiments show that the moisturizing time of the protective agent can reach more than 90 minutes, the light transmittance exceeds 98%, and corneal epithelium injury repair can be remarkably accelerated. The invention further provides a preparation method of the protective agent, and the preparation method is simple in process and suitable for industrial production.
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