Multi-union blood bag capable of removing white blood and used for preserving blood of cats and dogs

Abstract

The invention discloses a multi-union blood bag capable of removing white blood for preserving blood of cats and dogs, which relates to the field of multi-union blood bags for animals and comprises a blood collection bag, a blood taking needle connected with a blood inlet of the blood collection bag, a filtered blood bag connected with a blood outlet of the blood collection bag, and a red blood cell preserving fluid bag connected with the filtered blood bag. The leukocyte filter is arranged between the blood collection bag and the filtered blood bag, the mixing structure is arranged between the blood collection bag and the blood taking needle and can realize mixing of collected blood and an anticoagulant, the anticoagulant bag is connected with the mixing structure, and the one-way control structure is arranged between the anticoagulant bag and the mixing structure; according to the multi-union blood bag capable of removing white blood and used for cat and dog blood preservation, through the mixing structure and the one-way control structure, instant and sufficient mixing of blood and anticoagulant is achieved, and therefore the problems that anticoagulation is delayed and the microclot forming probability is high are solved, and the blood collection quality and preservation safety are improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of multi-connected blood bags for animals, in particular to a white-removable multi-connected blood bag for cat and dog blood preservation. BACKGROUND

[0002] In veterinary clinical treatment, cat and dog often need blood transfusion treatment due to trauma, surgery massive hemorrhage, blood disease and other conditions, and the multi-connected blood bag is the core medical device for blood collection, separation, preservation and infusion of cat and dog. The existing white-removable multi-connected blood bag for cat and dog is usually composed of a blood collection needle, a blood collection bag, a filtered blood bag, a red blood cell preservation liquid bag and a white blood cell filter, and the basic working process is to collect blood into the blood collection bag through the blood collection needle, then filter and remove white blood cells through the white blood cell filter, and finally add the preservation liquid in the red blood cell preservation liquid bag for preservation.

[0003] However, the existing multi-connected blood bag generally adopts a passive mode of blood collection first and anticoagulation later, that is, the anticoagulant is pre-packaged in the blood collection bag, and the blood flows into the collection bag through the blood collection needle and pipeline, and then the blood and the anticoagulant need to be mixed by manual shaking of the bag body by medical staff. During the process of blood flowing out of the cat and dog blood vessels and into the collection bag and contacting with the anticoagulant, the blood has started the coagulation cascade reaction, the platelets are activated and release ADP and thromboxane A2, which promotes the aggregation of platelets to form initial microthrombus; at the same time, the blood coagulation factors in the blood are activated after contacting with the inner wall of the pipeline, starting the endogenous coagulation pathway and generating fibrin monomers. Especially for cat and dog blood collection, due to the animal stress reaction leading to blood vessel contraction, low cooperation degree causing blood collection needle displacement and other problems, the blood flow rate often decreases suddenly, which further prolongs the residence time of blood in the pipeline, thereby increasing the probability of microthrombus formation.

[0004] The formed microthrombus not only blocks the subsequent white blood cell filter, leading to a decrease in filtration efficiency, and even causing the filter to break; more seriously, if the microthrombus that is not completely intercepted enters the cat and dog body with the blood infusion, it will block the capillary vessels, causing serious complications such as pulmonary embolism and microcirculation disorder, endangering the life of the animal. SUMMARY

[0005] The purpose of the present application is to provide a white-removable multi-connected blood bag for cat and dog blood preservation, which realizes the immediate and sufficient mixing of blood and anticoagulant through the mixing structure and one-way control structure, thereby solving the problems of anticoagulation delay and high probability of microthrombus formation, and improving the blood collection quality and preservation safety.

[0006] The above-mentioned optimized structure of the present application is realized by the following technical scheme: a white-removable multi-connected blood bag for cat and dog blood preservation, comprising a blood collection bag; A blood collection needle connected with the blood inlet of the blood collection bag; A filtered blood bag connected with the blood outlet of the blood collection bag; A red blood cell storage solution bag connected with the filtered blood bag; A leukocyte filter arranged between the blood collection bag and the filtered blood bag; Further comprising a mixing structure arranged between the blood collection bag and the blood collection needle, which can realize the mixing of collected blood and anticoagulant; An anticoagulant bag connected with the mixing structure; A one-way control structure arranged between the anticoagulant bag and the mixing structure.

[0007] In some embodiments, the mixing structure comprises a primary mixing component arranged between the blood collection bag and the blood collection needle and connected with the one-way control structure; A deep mixing component arranged between the blood collection bag and the primary mixing component.

[0008] In some embodiments, the primary mixing component comprises a primary mixing column arranged between the blood collection bag and the blood collection needle; A front cavity arranged on the side of the primary mixing column close to the blood collection needle and in communication with the blood collection needle, and the front cavity is filled with anticoagulant; A rear cavity arranged on the side of the primary mixing column close to the blood collection bag and in communication with the blood collection bag, and the rear cavity is connected with the one-way control structure; A barrier membrane arranged in the primary mixing column and between the front cavity and the rear cavity.

[0009] In some embodiments, the barrier membrane is made of a material that is soluble in contact with isotonic blood.

[0010] In some embodiments, the rear cavity comprises an inflow region arranged on the side of the barrier membrane away from the front cavity; An outflow region arranged on the side of the inflow region away from the barrier membrane; A mixing region arranged between the inflow region and the outflow region and connected with the one-way control structure, and the diameter of the mixing region is smaller than the diameter of the side of the inflow region away from the mixing region and the side of the outflow region away from the mixing region.

[0011] In some embodiments, the deep mixing component comprises a deep mixing column arranged between the primary mixing component and the blood collection bag; a deep mixing cavity coaxially penetrating the deep mixing column; a flow pipe coaxially arranged in the deep mixing cavity; a plurality of spiral flow guide fins arranged annularly between the flow pipe and the inner wall of the deep mixing cavity; a deep mixing plate coaxially arranged between the deep mixing cavity and the blood collection bag, and gaps are left between the deep mixing plate and the flow pipe and the inner wall of the deep mixing cavity.

[0012] In some embodiments, the one-way control structure comprises a control pipe arranged between the anticoagulant bag and the mixing structure; a sealing pipe coaxially arranged on the side of the control pipe close to the mixing structure; a sealing film coaxially arranged in the control pipe and attached to the sealing pipe; a control micro slit arranged in the middle of the sealing film.

[0013] In some embodiments, the sealing film is made of soft medical silicone or flexible polyvinyl chloride material.

[0014] In some embodiments, the blood collection bag comprises a collection bag body arranged between the white blood cell filter and the mixing structure; a blood inlet pipe arranged on the collection bag body; a filter screen arranged obliquely on the top of the collection bag body, and the blood inlet pipe is arranged above the filter screen.

[0015] In some embodiments, a transfer bag set is further arranged between the filtered blood bag and the red blood cell preservation solution bag; the transfer bag set comprises a transfer pipe arranged between the filtered blood bag and the red blood cell preservation solution bag; a plurality of transfer bags connected to the transfer pipe; a flow stop clamp arranged between the transfer bag and the transfer pipe.

[0016] The one or more technical solutions described above in the embodiments of the present application have at least the following technical effects or advantages: (1) The present application sets a mixing structure between the blood collection needle and the blood collection bag, uses the blood triggering dissolution characteristics of the pre-charging start anticoagulant and barrier membrane to mix the blood with the anticoagulant in vitro, realizes the instant and sufficient mixing of blood and anticoagulant, solves the problems of anticoagulation delay and high probability of micro-clot formation, and improves the blood collection quality and storage safety.

[0017] (2) The two-stage mixing structure combining the primary mixing component and the deep mixing component is adopted, the multiple mechanisms of flow rate change, vortex forced mixing and liquid flow impact are adopted, so that the anticoagulant and the blood are fully mixed, and the influence of local concentration unevenness on blood activity or anticoagulation effect is avoided.

[0018] (3) The one-way control structure adopts the structure of the elastic sealing film and the control micro gap, low-pressure rapid opening, zero-pressure automatic sealing are realized, the risk of blood backflow pollution of the anticoagulant bag is completely eliminated, and the safety of blood transfusion is ensured.

[0019] (4) The filtering net is integrated in the blood collection bag to realize initial filtering of blood into the bag, impurities are intercepted, the downstream white blood cell filter is protected, the filter clogging probability is reduced, and the subsequent blood processing efficiency is improved. BRIEF DESCRIPTION OF DRAWINGS

[0020] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the embodiments or the prior art description will be briefly introduced as follows. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative labor.

[0021] Figure 1 It is a structural schematic diagram of the embodiment 1 of the present application. Figure 2 It is a sectional structural schematic diagram of the primary mixing component of the embodiment 1 of the present application. Figure 3 It is a sectional structural schematic diagram of the deep mixing component of the embodiment 1 of the present application. Figure 4 It is a sectional structural schematic diagram of the one-way control structure in the embodiment 1 of the present application. Figure 5 It is a structural schematic diagram of the embodiment 2 of the present application.

[0022] In the figure: 1, blood collection bag; 11, collection bag body; 12, blood inlet tube; 13, filtering net; 2, blood collection needle; 3, filtered blood bag; 4, red blood cell preservation liquid bag; 5, transfer bag group; 51, transfer tube; 52, transfer bag; 53, flow stop clamp; 6, white blood cell filter; 7, mixing structure; 71, primary mixing column; 72, front cavity; 73, rear cavity; 731, inflow area; 732, outflow area; 733, mixing area; 74, barrier film; 75, deep mixing column; 76, deep mixing cavity; 77, flow-through tube; 78, flow guide fin; 79, deep mixing plate; 8, anticoagulant bag; 9, one-way control structure; 91, control tube; 92, sealing tube; 93, sealing film; 94, control micro gap. DETAILED DESCRIPTION

[0023] Embodiments of the present application are described in detail below with reference to the attached drawing figures, wherein the same or like reference numerals and characters throughout the figures denote the same elements or elements with the same functions. The embodiments described below are exemplary and are intended to be illustrative of the present application and are not to be used to limit the present application.

[0024] In the description of the present application, it is to be understood that the orientations or positional relationships indicated by the terms "length", "width", "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like are based on the orientations or positional relationships shown in the drawings, and are merely intended to facilitate the description of the present application and simplify the description, and therefore cannot be understood as indicating or implying that the devices or elements indicated must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present application.

[0025] In addition, the terms "first", "second", "third", etc. are used only for descriptive purposes and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the technical features indicated. Therefore, the features defined with "first", "second", etc. can explicitly or implicitly include one or more of the features. In the description of the present application, the meaning of "a plurality of" is two or more, unless otherwise explicitly specified and limited.

[0026] In the present application, unless otherwise explicitly specified and limited, the terms "mounting", "connection", "connecting", "fixing" and the like should be understood broadly, for example, can be fixed connection, can also be detachable connection, or integral; can be mechanical connection, can also be electrical connection; can be directly connected, can also be indirectly connected through an intermediate medium; can be the internal communication of two elements or the interaction relationship between two elements. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0027] Example 1: Reference Figures 1-4The application discloses a white-cell-removing multi-bag blood bag for cat and dog blood preservation, which comprises a blood collection bag 1, a blood collection needle 2, a filtered blood bag 3, a red blood cell preservation liquid bag 4, a white blood cell filter 6, a mixing structure 7, an anticoagulant bag 8 and a one-way control structure 9. The blood collection bag 1 is an initial temporary storage carrier after blood collection, and the bag body can be made of low-temperature-resistant medical PVC material. The blood outlet of the blood collection bag 1 can be connected with the inlet of the white blood cell filter 6 through a sealed pipeline. The blood collection bag 1 can receive the anticoagulated blood treated by the mixing structure 7 and complete pre-filtering. The blood collection needle 2 can be made of medical-grade stainless steel material, and the needle tip is subjected to passivation treatment to reduce the damage to the blood vessels of cats and dogs. The tail end of the blood collection needle 2 can be sealedly connected with the inlet of the mixing structure 7 through a standard luer connector. After the front end of the blood collection needle 2 is inserted into the blood vessels of cats and dogs, the blood collection needle 2 can provide a channel for blood flowing into the system. The filtered blood bag 3 can store clean blood after the white blood cells are removed by the white blood cell filter 6. The outside of the bag body can be printed with a volume scale. The inlet of the filtered blood bag 3 can be connected with the outlet of the white blood cell filter 6 through a sealed pipeline. The outlet of the filtered blood bag 3 can be connected with a transfer bag group 5 through a sealed pipeline. The inside of the red blood cell preservation liquid bag 4 can be pre-filled with special red blood cell preservation liquid for cats and dogs. The red blood cell preservation liquid bag 4 can be connected with the transfer bag group 5 through a sealed pipeline and can be injected as needed when blood is divided and stored, so that the survival time of red blood cells is prolonged. The white blood cell filter 6 is connected in series on the pipeline between the blood collection bag 1 and the filtered blood bag 3. The white blood cell filter 6 can be made of composite fiber non-woven fabric material, and the pore size thereof can be 10-45 mu. The white blood cell filter 6 can trap or adhere the white blood cells in the blood, so that the immune rejection reaction during blood transfusion is reduced. The mixing structure 7 is arranged between the blood collection bag 1 and the blood collection needle 2, so that the blood and the anticoagulant can be instantaneously and uniformly mixed, the anticoagulation delay is avoided, and the blood and the anticoagulant are uniformly mixed. The anticoagulant bag 8 can be made of light-proof medical film to prevent the anticoagulant from being degraded by light. The inside of the anticoagulant bag 8 can be pre-filled with ACD, CPD or CPDA anticoagulant. The anticoagulant bag 8 is connected with the mixing structure 7 through a sealed pipeline, so that the blood and the anticoagulant can be mixed with continuous anticoagulant supply. The one-way control structure 9 is arranged on the pipeline between the anticoagulant bag 8 and the mixing structure 7, so that the one-way flow of the anticoagulant can be realized, the blood backflow to contaminate the anticoagulant bag is avoided, and the timing and rate of anticoagulant supply can be accurately controlled.

[0028] In some embodiments, the mixing structure 7 comprises a primary mixing component and a deep mixing component. The primary mixing component is arranged between the blood collection bag 1 and the blood collection needle 2 and is connected with the one-way control structure 9. The blood can be contacted with the anticoagulant when the blood is separated from the body, so that the effect of anticoagulation when the blood is separated from the body is realized. The deep mixing component is arranged between the blood collection bag 1 and the primary mixing component. The deep mixing component can forcibly destroy the laminar flow state of the liquid flow, so that the anticoagulant and the blood molecules are uniformly mixed. The deep mixing component is suitable for the scene that the blood flow speed of cats and dogs fluctuates greatly.

[0029] In some embodiments, the primary mixing assembly includes a primary mixing column 71, a front chamber 72, a rear chamber 73, a barrier membrane 74, the primary mixing column 71 can be made of transparent medical polyolefin material, which can facilitate observation of the internal state, the primary mixing column 71 can be cylindrical, and the two ends are connected with the blood collection needle 2 and the deep mixing assembly through sealed pipelines, which can provide support for the internal chamber, the front chamber 72 is arranged on the side of the primary mixing column 71 close to the blood collection needle 2, and the volume can be 1-2 mL, which can be adapted according to the target blood collection volume, and the ACD, CPD or CPDA anticoagulant is pre-filled before leaving the factory, and the pipeline of the front chamber 72 and the blood collection needle 2 is directly connected; the connection between the blood collection needle 2 and the primary mixing column 71 can be provided with an anti-backflow structure to ensure that the pre-filled anticoagulant in the front chamber 72 will not leak before the blood collection starts, and when the blood collection needle 2 is inserted into the blood vessel, the blood flows into the front chamber 72 under the action of the system negative pressure, and is preliminarily mixed with the pre-filled anticoagulant to block the blood clotting reaction from the source; the rear chamber 73 is arranged on the side of the primary mixing column 71 close to the deep mixing assembly, and the volume can be 3-4 mL, the side wall thereof is connected with the one-way control structure 9 through a branch pipe, and the rear end is connected with the deep mixing assembly, the barrier membrane 74 seals and separates the front chamber 72 and the rear chamber 73, and can be made of a water-soluble high-molecular polymer composite membrane, which can be made by mixing hydroxypropyl methyl cellulose and polyvinyl alcohol at a ratio of 3:1, the barrier membrane 74 can maintain structural integrity in a dry state, and can completely dissolve within 2-5 seconds after contacting isotonic blood such as dog and cat blood; after the barrier membrane 74 dissolves, the mixed solution of blood and anticoagulant in the front chamber 72 flows into the rear chamber 73, and at the same time triggers the one-way control structure 9 to open, and the main anticoagulant flows into the rear chamber 73 from the anticoagulant bag 8, thereby realizing continuous supply of the anticoagulant.

[0030] In some embodiments, the rear chamber 73 includes an inflow area 731, an outflow area 732 and a mixing area 733, the inflow area 731 is arranged on the side of the barrier membrane 74 away from the front chamber 72, and the diameter gradually decreases towards the outflow area 732, which can smoothly increase the speed of the mixed solution entering the inflow area 731, the outflow area 732 is arranged on the side of the inflow area 731 away from the barrier membrane 74, and the diameter gradually increases from the mixing area 733 to the deep mixing assembly, so that the high-speed fluid is smoothly decelerated, avoiding the generation of air bubbles when entering the deep mixing assembly due to sudden change of flow rate, the mixing area 733 is arranged between the inflow area 731 and the outflow area 732 and is connected with the one-way control structure 9, and the diameter of the mixing area 733 is smaller than that of the side of the inflow area 731 away from the mixing area 733 and the side of the outflow area 732 away from the mixing area 733, when the mixed solution flows through the mixing area 733, the flow rate increases due to the decrease of the cross-sectional area, forming a local negative pressure, accelerating the main anticoagulant transported by the one-way control structure 9 to be mixed, and the turbulent flow generated by the high-speed fluid enhances the mixing effect.

[0031] In some embodiments, the deep mixing assembly comprises a deep mixing column 75, a deep mixing cavity 76, a flow pipe 77, a plurality of spiral flow guide fins 78, and a deep mixing plate 79. The deep mixing column 75 can be made of the same medical polyolefin material as the primary mixing column 71, and is sealingly connected to the rear cavity 73 and the blood inlet tube 12 of the blood collection bag 1 at both ends. The deep mixing cavity 76 is coaxially arranged through the deep mixing column 75 to provide a mixing channel for the liquid flow. The flow pipe 77 is coaxially arranged in the deep mixing cavity 76, and the front end is aligned with the outflow area 732 of the rear cavity 73 to guide the mixed liquid to flow along the inner wall of the flow pipe 77, avoiding uneven mixing caused by the liquid flow directly impacting the inner wall of the deep mixing cavity 76. The plurality of flow guide fins 78 are annularly arranged between the inner wall of the flow pipe 77 and the deep mixing cavity 76, and the spiral angle can be 25°-30°, and the number can be 4-6. When the mixed liquid flows through the flow guide fins 78, it is forced to form a high-speed vortex, which destroys the laminar flow state of the liquid flow and fully interweaves the anticoagulant and the blood. The deep mixing plate 79 is coaxially arranged at one end of the deep mixing cavity 76 close to the blood collection bag 1, and there is a gap of 0.2-0.3 cm between the deep mixing plate 79 and the inner wall of the flow pipe 77 and the deep mixing cavity 76. When the mixed liquid in the outflow area 732 enters the deep mixing cavity 76, part of it flows along the flow pipe 77, and part of it flows along the spiral flow channel formed by the flow pipe 77, the inner wall of the deep mixing cavity 76, and the plurality of flow guide fins 78. The mixed liquid flowing along the flow pipe 77 will hit the deep mixing plate 79 and mix with the spiral flowing mixed liquid, and finally flow from the gap between the deep mixing plate 79 and the inner wall of the deep mixing cavity 76 to the blood collection bag 1. This process can further disrupt the fluid motion trajectory, improve the mixing uniformity of the blood and the anticoagulant, eliminate the problem of local high or low anticoagulant concentration, reduce the anticoagulant concentration variation coefficient of the final mixed liquid, and reduce the content of microclots in the mixed liquid.

[0032] In some embodiments, the one-way control structure 9 includes a control tube 91, a sealing tube 92, a sealing film 93, and a control micro-slit 94. The control tube 91 can be made of medical-grade hard PVC. One end of the control tube 91 can be connected to the anticoagulant bag 8 through the sealing tube, and the other end can be sealingly connected to the branch tube of the rear cavity 73 of the primary mixing assembly, thereby providing a channel for the flow of anticoagulant. The sealing tube 92 can be coaxially arranged on the side of the control tube 91 close to the rear cavity 73. The sealing tube 92 is made of the same material as the control tube 91, and the inner wall can be polished to reduce the resistance to the flow of anticoagulant. The sealing film 93 can be made of soft medical silicone or flexible polyvinyl chloride. Such materials have good elasticity and sealing properties. When there is no pressure, the control micro-slit 94 can be tightly closed by relying on its own elasticity. When the pressure reaches a threshold value, the control micro-slit 94 can be quickly opened, thereby ensuring the sensitivity and reliability of one-way control. The sealing film 93 is coaxially attached to the end face of the sealing tube 92, and relies on the material's own elasticity to form an interference fit with the sealing tube 92, thereby achieving initial sealing. The control micro-slit 94 can be formed in the middle of the sealing film 93 by using a laser precision cutting process. The shape of the control micro-slit 94 can be Y-shaped or star-shaped, and the slit length can be 2-3 mm. In the natural state, the control micro-slit 94 is tightly closed due to the elastic tension of the sealing film 93, thereby achieving the separation between the anticoagulant bag 8 and the rear cavity 73.

[0033] Before blood collection, the control micro-slit 94 of the sealing film 93 is closed, preventing the leakage of anticoagulant from the anticoagulant bag 8 and preventing blood backflow. When the barrier film 74 of the primary mixing assembly dissolves and the mixed solution enters the rear cavity 73, a local negative pressure is generated when the mixed solution flows through the mixing area 733. This pressure is transmitted to the outside of the sealing film 93 through the branch tube of the rear cavity 73, causing the pressure on the outside of the sealing film 93 to be lower than the pressure on the inside of the sealing film 93. The outside of the sealing film 93 refers to the side of the sealing film 93 close to the rear cavity 73, and the inside of the sealing film 93 refers to the side of the sealing film 93 away from the rear cavity 73. Thus, the elastic tension of the sealing film 93 is overcome, and the control micro-slit 94 is stretched from the inside to the outside, forming a fluid channel of 0.2-0.3 mm. The main anticoagulant in the anticoagulant bag 8 flows into the mixing area 733 of the rear cavity 73 through the control tube 91, the sealing tube 92, and the control micro-slit 94 under the action of the pressure difference, and mixes with the blood. After blood collection is completed, the pressure in the rear cavity 73 decreases to atmospheric pressure, and the sealing film 93 resets by relying on its own elasticity, causing the control micro-slit 94 to close again, thereby completely eliminating the risk of blood backflow contaminating the anticoagulant bag 8.

[0034] In some embodiments, the blood collection bag 1 comprises a collection bag body 11, an inlet blood tube 12, and a filter screen 13. The collection bag body 11 can be made of low-temperature-resistant medical PVC material. A transparent observation window can be provided on one side of the collection bag body 11 to facilitate observation of the state of the blood and the retention of impurities. The other side can be provided with an outlet blood tube connected to the white blood cell filter 6. The inlet blood tube 12 can be made of medical-grade soft PVC tube. One end is sealingly connected to the deep mixing cavity 76 of the deep mixing assembly, and the other end penetrates the top of the collection bag body 11 and extends directly above the filter screen 13 to ensure that the mixed liquid directly impacts the filter screen 13. The filter screen 13 can be made of medical-grade nylon mesh or polyester mesh with a pore size of 150-200 μm and a thickness of 0.1-0.15 mm. It can be fixed to the inner top of the collection bag body 11 at an inclination angle of 30°-45° by heat sealing process.

[0035] After the blood is mixed by the deep mixing assembly, it flows out of the inlet blood tube 12 and vertically impacts the filter screen 13 arranged at an inclination. The small clots, skin tissue fragments and other impurities in the blood with a diameter greater than 150 μm are retained by the filter screen 13, while the red blood cells with a diameter of 6-8 μm, white blood cells with a diameter of 10-15 μm, and platelets with a diameter of 2-3 μm can pass through the filter screen 13 and flow into the bottom of the collection bag body 11 for temporary storage. The inclined design not only increases the effective filtering area of the filter screen 13, but also avoids the accumulation of impurities to block the mesh, ensuring stable blood flow speed. At the same time, the retained impurities are concentrated at the lower end of the filter screen 13, making it easy for medical staff to judge the quality of blood collection through the observation window. The blood collection bag 1 temporarily stores blood while the pre-filtering function of the filter screen 13 intercepts small clots and impurities in advance, protecting the downstream white blood cell filter 6.

[0036] Embodiment 2: Reference Figure 5 To meet the needs of small dogs and cats such as Chihuahua and cat for single small dose blood transfusion, a transfer bag set 5 is added between the filtered blood bag 3 and the red blood cell preservation liquid bag 4 to realize flexible sub-packaging of blood and accurate addition of preservation liquid. The transfer bag set 5 comprises a transfer tube 51, a plurality of transfer bags 52, and a flow stop clamp 53. The transfer tube 51 can be made of medical-grade soft PVC tube and can be designed in Y shape or tree shape. One end of the main road is sealingly connected to the outlet of the filtered blood bag 3. One end of the branch is connected to the red blood cell preservation liquid bag 4, and the remaining branches are respectively connected to each transfer bag 52. The material of the plurality of transfer bags 52 is the same as that of the filtered blood bag 3. Each transfer bag 52 is marked with an independent number and a volume scale for easy identification and measurement. The flow stop clamp 53 can be made of medical-grade ABS material and can be in an elastic pressing structure. One flow stop clamp 53 is provided on each branch of the connection between the transfer tube 51 and the transfer bag 52 to realize the opening and closing of the pipeline by pressing the clamp body.

[0037] When the blood enters the filtered blood bag 3 through the leukocyte filter 6, if multiple samples need to be divided, the corresponding flow stop clamp 53 of the target transfer bag 52 can be opened, the remaining flow stop clamps 53 are closed, and the blood is introduced into the target transfer bag 52 by squeezing the filtered blood bag 3 or using the gravity difference; after the division is completed, the flow stop clamp 53 is closed to realize independent sealed preservation of the blood; if red blood cell preservative solution needs to be added, the flow stop clamp 53 of the connecting branch of the transfer tube 51 and the red blood cell preservative solution bag 4 is opened, so that the preservative solution flows into the filtered blood bag 3 or the designated transfer bag 52, and after mixing, the flow stop clamp 53 is closed, the blood preservation time is prolonged, and the pollution risk caused by multiple exposures of the blood is avoided.

[0038] The specific working principle is as follows: The blood flows into the front cavity 72 of the preliminary mixing assembly of the mixing structure 7, is preliminarily mixed with the pre-charged anticoagulant, triggers the dissolution of the blocking membrane 74, after the blocking membrane 74 is dissolved, the mixed solution enters the rear cavity 73, the local negative pressure generated by the rear cavity 73 triggers the opening of the one-way control structure 9, the main anticoagulant flows into the mixing area 733 of the rear cavity 73 and is mixed with the blood, the preliminary mixed solution enters the deep mixing assembly, is divided by the flow guide fin 78 and the flow pipe 77, forms vortex flow and direct current, and is re-mixed after impacting the deep mixing plate 79, realizes the molecular-level uniform mixing of the anticoagulant and the blood, the uniformly mixed blood flows into the blood collection bag 1, is intercepted by the filter screen 13, and is temporarily stored in the collection bag body 11, the pipeline between the blood collection bag 1 and the leukocyte filter 6 is opened, the blood flows into the filtered blood bag 3 after the leukocytes are removed by the filter, is controlled by the flow stop clamps 53 of the transfer bag group 5, realizes the division of the blood or the mixing with the red blood cell preservative solution, and finally completes the sealed preservation or preparation of the blood for blood transfusion.

[0039] Through the structure adaptation and function cooperation of each assembly, the multi-connected blood bag completely eliminates the anticoagulation empty window period of the traditional blood bag, the mixing uniformity and impurity interception efficiency are significantly improved, and at the same time, the flexible division capacity is provided, and the clinical needs of dog and cat blood collection are completely adapted.

[0040] The above examples are only used to illustrate the technical solutions of the present application, but not limit them; although the present application has been described in detail with reference to the foregoing examples, those skilled in the art should understand that the technical solutions recorded in the foregoing examples can be modified, or some technical features can be replaced by equivalents; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the present application.

Claims

1. A white blood cell removal multi-bag for cat and dog blood preservation, comprising a blood collection bag (1); a blood collection needle (2) connected with the blood inlet of the blood collection bag (1); a filtered blood bag (3) connected with the blood outlet of the blood collection bag (1); a red blood cell preservation solution bag (4) connected with the filtered blood bag (3); a white blood cell filter (6) arranged between the blood collection bag (1) and the filtered blood bag (3); characterized in that a mixing structure (7) arranged between the blood collection bag (1) and the blood collection needle (2) to realize mixing of collected blood and anticoagulant; an anticoagulant bag (8) connected with the mixing structure (7); a one-way control structure (9) arranged between the anticoagulant bag (8) and the mixing structure (7).

2. The detachable white blood bag for cat and dog blood preservation according to claim 1, characterized in that: The mixing structure (7) comprises a preliminary mixing assembly arranged between the blood collection bag (1) and the blood collection needle (2) and connected with the one-way control structure (9); a deep mixing assembly arranged between the blood collection bag (1) and the preliminary mixing assembly.

3. The detachable white blood bag for cat and dog blood preservation according to claim 2, characterized in that: The preliminary mixing assembly comprises a preliminary mixing column (71) arranged between the blood collection bag (1) and the blood collection needle (2); a front cavity (72) arranged on the side of the preliminary mixing column (71) close to the blood collection needle (2) and in communication with the blood collection needle (2), and the front cavity (72) is filled with anticoagulant; a rear cavity (73) arranged on the side of the preliminary mixing column (71) close to the blood collection bag (1) and in communication with the blood collection bag (1), and the rear cavity (73) is connected with the one-way control structure (9); a barrier membrane (74) arranged in the preliminary mixing column (71) and between the front cavity (72) and the rear cavity (73).

4. The detachable white blood bag for cat and dog blood preservation according to claim 3, characterized in that: The barrier membrane (74) is made of a material that can be dissolved by isotonic blood in contact.

5. The detachable white blood bag for blood storage of cats and dogs according to claim 3, characterized in that: The rear cavity (73) comprises an inflow area (731) arranged on the side of the barrier membrane (74) away from the front cavity (72); an outflow area (732) arranged on the side of the inflow area (731) away from the barrier membrane (74); a mixing area (733) arranged between the inflow area (731) and the outflow area (732) and connected with the one-way control structure (9), and the diameter of the mixing area (733) is smaller than the diameter of the side of the inflow area (731) away from the mixing area (733) and the side of the outflow area (732) away from the mixing area (733).

6. The detachable white blood cell removing multi-bag for blood storage of cats and dogs according to claim 2, characterized in that: The deep mixing assembly comprises a deep mixing column (75) arranged between the preliminary mixing assembly and the blood collection bag (1); a deep mixing cavity (76) coaxially penetrating through the deep mixing column (75); A flow pipe (77) coaxially arranged in the deep mixing cavity (76); A plurality of spiral flow guide fins (78) annularly arranged between the flow pipe (77) and the inner wall of the deep mixing cavity (76); A deep mixing plate (79) coaxially arranged between the deep mixing cavity (76) and the blood collection bag (1), and the deep mixing plate (79) is spaced from the flow pipe (77) and the inner wall of the deep mixing cavity (76).

7. The detachable white blood cell removing multi-bag for blood storage of cats and dogs according to claim 1, characterized in that: The one-way control structure (9) comprises a control pipe (91) arranged between the anticoagulant bag (8) and the mixing structure (7); A sealing pipe (92) coaxially arranged on one side of the control pipe (91) close to the mixing structure (7); A sealing film (93) coaxially arranged in the control pipe (91) and attached to the sealing pipe (92); A control micro-slit (94) arranged in the middle of the sealing film (93).

8. The detachable white blood bag for cat and dog blood preservation according to claim 7, characterized in that: The sealing film (93) is made of soft medical silicone or flexible polyvinyl chloride material.

9. The detachable white blood bag for blood storage of cats and dogs according to claim 1, wherein: The blood collection bag (1) comprises a collection bag body (11) arranged between the white blood cell filter (6) and the mixing structure (7); A blood inlet pipe (12) arranged on the collection bag body (11); A filter screen (13) obliquely arranged at the top of the collection bag body (11), and the blood inlet pipe (12) is arranged above the filter screen (13).

10. The detachable white blood bag for blood storage of cats and dogs according to claim 1, wherein: Further comprising a transfer bag group (5) arranged between the filtered blood bag (3) and the red blood cell preservation solution bag (4); The transfer bag group (5) comprises a transfer pipe (51) arranged between the filtered blood bag (3) and the red blood cell preservation solution bag (4); A plurality of transfer bags (52) connected with the transfer pipe (51); A flow stop clamp (53) arranged between the transfer bag (52) and the transfer pipe (51).

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