Geranyl geraniol synthetase mutant and application thereof

Abstract

The invention relates to the field of bioengineering and chemical synthesis, in particular to a geranyl geraniol synthetase mutant and application thereof, the amino acid sequence of geranyl geraniol synthetase is selected from any one of the following (a) or (b): (a) an amino acid sequence obtained by substitution, deletion or addition of at least one amino acid to a sequence as shown in SEQ ID No: 1 and derivation; (b) an amino acid sequence having at least 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% identity with (a). The invention provides a brand new method for efficiently producing alpha-tocotrienol by constructing a geranyl geraniol synthesis route in saccharomyces cerevisiae to obtain a genetic engineering strain and then chemically synthesizing alpha-tocotrienol by using geranyl geraniol from a biological source as a raw material.

Description

Technical Field

[0001] This invention relates to the fields of bioengineering and chemical synthesis, specifically to the identification of the geraniol synthase domain, the construction and application of geraniol synthase mutants, the construction of high-yielding geraniol strains, and a method for synthesizing α-tocotrienols from geraniol obtained from biological sources. Background Technology

[0002] Tocotrienols are a type of vitamin E that differs from traditional tocopherols in that they possess an unsaturated isoprene side chain with three double bonds, leading to significant differences in certain biological functions. Tocotrienols exhibit superior physiological functions compared to traditional tocopherols, particularly in neuroprotection, antioxidation, anticancer activity, and cholesterol reduction. Naturally occurring tocotrienols exist in four forms: α-, β-, γ-, and δ-tocotrienols. While different conformations of tocotrienols possess nearly similar physiological activities, α-tocotrienol exhibits higher oral bioavailability and stronger antioxidant activity compared to other tocotrienol isomers.

[0003] The complex unsaturated structures of tocotrienols hinder their commercial synthesis, resulting in low yields and purity. Currently, tocotrienols are mainly obtained from crude palm oil, with natural palm oil containing up to 800 mg / kg of tocotrienols. However, synthetic biology techniques have significantly advanced the de novo biosynthesis of tocotrienols in microorganisms. In 2020, researchers at Zhejiang University successfully achieved the biosynthesis of 320 mg / L of tocotrienols in Saccharomyces cerevisiae; however, the complexity of the biosynthetic pathway limits further yield increases.

[0004] Tocotrienols obtained through existing techniques are mixtures of various isomers, making it impossible to obtain a single configuration of tocotrienol, especially α-tocotrienol, which has a wider range of applications. Furthermore, unlike the synthesis of vitamin E, one-step acid catalysis rarely yields the target product. Summary of the Invention

[0005] To address the above technical problems, this disclosure provides an efficient method for obtaining α-tocotrienols from bio-based geraniol via a two-step Lewis acid-catalyzed reaction.

[0006] On the one hand, this disclosure provides a geraniol synthase mutant derived from *Thielavia arenaria*, the amino acid sequence of which is selected from either (a) or (b) below:

[0007] (a) An amino acid sequence derived from the sequence shown in SEQ ID No:1 by substitution, deletion or addition of at least one amino acid;

[0008] (b) has an amino acid sequence that is at least 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to (a).

[0009] In some embodiments, the amino acid sequence of the above-mentioned geraniol synthase mutant is an amino acid sequence derived from the sequence shown in SEQ ID No:1 by substituting at least one amino acid residue in amino acid residues from position 60 to 715.

[0010] In some preferred embodiments, the number of amino acid residues substituted is 1, 2, 3, 4, 5, 6, 7, 8 or 9.

[0011] In some preferred embodiments, the aforementioned substituted sites include at least one of the following positions: 60, 88, 173, 174, 188, 195, 196, 197, 228, 243, 245, 252, 431, 441, 475, 571, 604, 605, or 715 of SEQ ID No:1.

[0012] In some embodiments, the amino acid residue substitutions in the amino acid sequence of the above-mentioned geranyl geraniol synthase mutant include at least one conserved substitution and at least one non-conserved substitution.

[0013] In some preferred embodiments, the aforementioned substitutions include at least one of S60G, I88L, K173R, H174D, Y188F, G195A, Y196P, W197F, S228A, E243A, A245F, P252L, V431I, T441D, F475L, I571L, F604Y, K605Q, and E715K, and / or the amino acid sequence of the geraniol synthase mutant is the sequence shown in SEQ ID No: 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 41, 45, 49, 51, 55, 57, or 61;

[0014] More preferably, the amino acid sequence of the geraniol synthase mutant is the sequence shown in SEQ ID No: 35, 37, 39, 43, 47, 53 or 59.

[0015] On the other hand, this disclosure provides a nucleic acid molecule that encodes the above-mentioned geraniol synthase mutant.

[0016] On the other hand, this disclosure provides a recombinant vector containing the aforementioned nucleic acid molecules.

[0017] On the other hand, this disclosure provides a recombinant cell containing the above-mentioned recombinant vector; the host cell of the recombinant cell is bacteria or fungi.

[0018] On the other hand, this disclosure provides a geraniol-efficient synthetic strain, which is a mutant strain of geraniol synthase that integrates and expresses the above-mentioned geraniol synthase into the genome of Saccharomyces cerevisiae.

[0019] On the other hand, this disclosure provides a method for preparing geraniol, which includes isolating and obtaining geraniol by culturing the aforementioned recombinant cells or by fermenting the aforementioned geraniol-efficient synthetic strain.

[0020] On the other hand, this disclosure provides a method for preparing α-tocotrienol, wherein the α-tocotrienol is prepared from geraniol obtained according to the aforementioned method as a raw material; preferably, the preparation method includes:

[0021] (1) Geraniol was prepared by the aforementioned method and then reacted with trimethylhydroquinone in a first contact reaction to obtain the chain product after the Friedel-Crafts reaction.

[0022] (2) The chain product and an aqueous solution of sodium dithionite are subjected to a second contact reaction to obtain the reduced phenol;

[0023] (3) The reduced phenol was cyclized under the catalysis of Lewis acid to obtain α-tocotrienol.

[0024] On the other hand, this disclosure provides the application of the aforementioned geraniol synthase mutant, nucleic acid molecule, recombinant vector, recombinant cell, geraniol high-efficiency synthesizing strain and preparation method in the fermentation production of α-tocotrienol.

[0025] The beneficial effects of this disclosure are at least as follows:

[0026] 1. A geranyl geraniol synthase derived from *Clostridium spp.* and its mutants, along with their corresponding coding genes, were discovered. This enzyme and its mutants can efficiently synthesize the product geranyl geraniol. Furthermore, the enzyme exhibits good robustness, demonstrating excellent catalytic activity for geranyl geraniol synthases encoding homologous amino acid sequences with over 83% homology.

[0027] 2. A high-yield geraniol strain was constructed, with a fermenter yield of 15.32 g / L. The product purity was higher than that of commercially available products, laying a solid foundation for the industrial application of geraniol.

[0028] 3. High-purity, single-configuration α-tocotrienols were synthesized from bio-derived geraniol via chemical synthesis, achieving a yield of 48.82%, which is superior to other existing technologies. Attached Figure Description

[0029] The accompanying drawings, which are incorporated in and form part of this specification, illustrate embodiments consistent with this specification and, together with the description, serve to explain the principles of this specification.

[0030] Figure 1 The results of LC-ESI-HRMS analysis of the in vitro reaction of the purified proteins 066PT and 066TC are shown.

[0031] Figure 2 The diagram shows the construction of plasmids pHM003, pHM004, and pHM005.

[0032] Figure 3 A schematic diagram of the construction of knockout boxes pHM034, pHM042, and pHM021 is shown;

[0033] Figure 4 The 1H NMR spectrum of the purified geraniol is shown.

[0034] Figure 5 The 13C NMR spectrum of the purified geraniol is shown.

[0035] Figure 6 The 1H NMR spectrum of the purified α-tocotrienol is shown.

[0036] Figure 7 The 13C NMR spectrum of the purified α-tocotrienol is shown. Detailed Implementation

[0037] I. Definition

[0038] In this disclosure, unless otherwise stated, scientific and technical terms used herein have meanings commonly understood by those skilled in the art. Furthermore, the terms and laboratory procedures related to protein and nucleic acid chemistry, molecular biology, cell and tissue culture, microbiology, and immunology used herein are all widely used terms and routine procedures in their respective fields. To better understand this disclosure, definitions and explanations of relevant terms are provided below. It should be understood that this disclosure is not limited to specific methods, reagents, compounds, compositions, or biological systems, and variations thereof are certainly possible. It should also be understood that the terminology used in this application is for describing specific embodiments only and is not intended to be limiting.

[0039] As used herein, the terms “a” and “an” as well as “the” and similar pronouns indicate singular and plural, unless otherwise specified herein or the context clearly contradicts them.

[0040] As used herein and unless otherwise stated, the terms “about” or “approximately” mean within 10% of a given value or range. Where an integer is required, the term means within 10% of a given value or range, rounded up or down to the nearest integer.

[0041] As used herein, the conjunction term "and / or" between multiple elements is understood to include both individual and combined options. For example, when two elements are joined by "and / or," the first option refers to the applicability of the first element without the second. The second option refers to the applicability of the second element without the first. The third option refers to the applicability of the first and second elements together. Any of these options is understood to fall within the scope of meaning and thus satisfies the requirement of the term "and / or" as used herein. The concurrent applicability of multiple options is also understood to fall within the scope of the term's meaning and thus satisfies the requirement of the term "and / or".

[0042] As used herein, the term "identity" refers to the degree to which two or more amino acid sequences, when aligned, have the same amino acid residues at the same positions. Amino acid identity can be expressed as a percentage and can also be used to assess the similarity and homology between sequences.

[0043] The amino acid composition of the amino acid sequence disclosed herein can be altered without substantially affecting its biological activity. For example, an amino acid sequence may contain one or more conserved amino acid substitutions. A conserved amino acid substitution is the substitution of one amino acid residue by another amino acid residue with a similar side chain. Amino acid residues are classified in the literature according to the nature of their side chains. Amino acid residues containing basic side chains include lysine, arginine, and histidine; amino acid residues containing acidic side chains and amide side chains include aspartic acid, glutamic acid, asparagine, and glutamine; amino acid residues with small aliphatic, nonpolar, or weakly polar side chains include glycine, alanine, threonine, serine, and proline; amino acid residues with large aliphatic, nonpolar side chains include leucine, isoleucine, and valine; aromatic amino acid residues include phenylalanine, tryptophan, and tyrosine; and amino acid residues with sulfur-containing side chains include cysteine ​​and methionine.

[0044] As used herein, the terms “nucleic acid,” “nucleotide,” and “polynucleotide” are used interchangeably to refer to deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and polymers thereof in single-stranded, double-stranded, or multi-stranded form. This term includes, but is not limited to, single-stranded, double-stranded, or multi-stranded DNA or RNA, genomic DNA, cDNA, DNA-RNA hybrids, or polymers containing purine and / or pyrimidine bases or other natural, chemically modified, biochemically modified, non-natural, synthetic, or derived nucleotide bases. In some embodiments, nucleic acids may include mixtures of DNA, RNA, and the like. The term also covers nucleic acids containing known analogs of natural nucleotides that have similar binding properties to a reference nucleic acid and are metabolized in a manner similar to naturally occurring nucleotides. “Nucleic acid” is used interchangeably with “gene,” “DNA,” and “mRNA” encoded by a gene.

[0045] As used herein, the term "vector" refers to a segment of DNA extracted from a virus, plasmid, or cell of a higher organism, into which a foreign DNA fragment may be inserted or has been inserted for cloning and / or expression purposes. In some embodiments, the vector can be stably maintained in the organism. A vector may contain, for example, an origin of replication, a selection marker or reporter gene, such as antibiotic resistance or GFP, and / or a multiple cloning site (MCS). The term includes linear DNA fragments (e.g., PCR products, linear plasmid fragments), plasmid vectors, viral vectors, granules, bacterial artificial chromosomes (BACs), yeast artificial chromosomes (YACs), etc.

[0046] As used herein, the terms "cell" and "host cell" are used interchangeably in this invention and refer to a cell that expresses or is capable of expressing the sequence to be expressed. The host cells of this invention express polynucleotides encoding polypeptides or RNA that have a variety of uses, including biotechnology, molecular biology, and clinical applications. Host cells include prokaryotic or eukaryotic cells, and examples of suitable host cells in this invention include, but are not limited to, bacterial and fungal cells.

[0047] As used herein, the term "homologous arm" refers to a flanking sequence on a knockout plasmid that is identical to the sequences flanking the knockout gene, used to identify and facilitate recombination. Specifically, an upstream homologous arm refers to a DNA segment identical to the upstream sequence of the knockout gene; a downstream homologous arm refers to a DNA segment identical to the downstream sequence of the knockout gene.

[0048] As used in this article, the term "5-FOA reverse screening" refers to the use of 5-fluoroorotic acid (5-FOA) for yeast reverse selection, a commonly used molecular genetic screening method. The specific implementation involves obtaining a single clone of *Saccharomyces cerevisiae* that has been verified by colony PCR, culturing it in YPD medium, washing it with water, then streaking the colony onto a plate containing 5-FOA, picking cells from the plate, and performing colony PCR verification.

[0049] II. Detailed Implementation Plan

[0050] On the one hand, this disclosure provides a geraniol synthase mutant derived from *Clostridium spp.*, the amino acid sequence of which is selected from either (a) or (b) below:

[0051] (a) An amino acid sequence derived from the sequence shown in SEQ ID No:1 by substitution, deletion or addition of at least one amino acid;

[0052] (b) has an amino acid sequence that is at least 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to (a).

[0053] In some embodiments, the amino acid sequence of the above-mentioned geraniol synthase mutant is an amino acid sequence derived from the sequence shown in SEQ ID No:1 by substituting at least one amino acid residue in amino acid residues from position 60 to 715.

[0054] In some preferred embodiments, the number of amino acid residues substituted is 1, 2, 3, 4, 5, 6, 7, 8 or 9.

[0055] In some preferred embodiments, the aforementioned substituted sites include at least one of the following positions: 60, 88, 173, 174, 188, 195, 196, 197, 228, 243, 245, 252, 431, 441, 475, 571, 604, 605, or 715 of SEQ ID No:1.

[0056] In some embodiments, the amino acid residues in the amino acid sequence of the aforementioned geraniol synthase mutant contain at least one conserved substitution and at least one non-conserved substitution.

[0057] In some preferred embodiments, the aforementioned substitutions include at least one of S60G, I88L, K173R, H174D, Y188F, G195A, Y196P, W197F, S228A, E243A, A245F, P252L, V431I, T441D, F475L, I571L, F604Y, K605Q, and E715K; and / or the amino acid sequence of the above-mentioned geraniol synthase mutant is the sequence shown in SEQ ID No: 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 41, 45, 49, 51, 55, 57, or 61.

[0058] In some preferred embodiments, the aforementioned substitutions include at least one conservative substitution and at least one non-conservative substitution at positions 60, 88, 173, 174, 188, 195, 196, 197, 228, 243, 245, 252, 431, 441, 475, 571, 604, 605, or 715 of SEQ ID No: 1. The amino acid residue substitutions include at least one of S60G, I88L, K173R, H174D, Y188F, G195A, Y196P, W197F, S228A, E243A, A245F, P252L, V431I, T441D, F475L, I571L, F604Y, K605Q, and E715K. For example, it can be any of the following combinations: I88L and E243A; I88L and G195A; I88L and P252L; E243A and G195A; E243A and P252L; G195A and P252L; E715K and T441D; E715K and I571L; E715K and F604Y; T441D and I571L; T441D and F604Y; I571L and F604Y; I88L, G195A; A, T441D and F604Y; I88L, G195A, E715K and F604Y; W197F, P252L, T441D and F604Y; W197F, P252L, E715K and F604Y; S228A, P252L, T441D and F604Y; S228A, P252L, E715K and F604Y; and / or the amino acid sequences of the geraniol synthase mutants obtained by substitution are those shown in SEQ ID No: 35, 37, 39, 43, 47, 53 or 59.

[0059] On the other hand, this disclosure provides a nucleic acid molecule that encodes the above-mentioned geraniol synthase mutant.

[0060] On the other hand, this disclosure provides a recombinant vector containing the aforementioned nucleic acid molecules.

[0061] On the other hand, this disclosure provides a recombinant cell containing the above-mentioned recombinant vector; the host cell of the recombinant cell is bacteria or fungi.

[0062] On the other hand, this disclosure provides a geraniol-efficient synthetic strain, which is a mutant strain of geraniol synthase that integrates and expresses the above-mentioned geraniol synthase into the genome of Saccharomyces cerevisiae.

[0063] In some embodiments, the aforementioned high-yield geraniol strain is a recombinant Saccharomyces cerevisiae, wherein the copy number of the mevalonate pathway genes in the recombinant Saccharomyces cerevisiae is ERG10, ERG13, tHMG1, ERG12, ERG8, MVD1, IDI1 = 2, 2, 3, 2, 2, 2, 2, and the copy number of the geraniol pyrophosphate synthase gene and the geraniol synthase gene is 1-3. Specifically, ERG10 encodes acetyl-CoA thiolysis enzyme, ERG13 encodes HMG-CoA synthase, tHMG1 encodes HMG-CoA reductase, ERG12 encodes mevalonate kinase, ERG8 encodes mevalonate-5-phosphate kinase, MVD1 encodes mevalonate pyrophosphate decarboxylase, and IDI1 encodes isoprene pyrophosphate isomerase.

[0064] On the other hand, this disclosure provides a method for preparing geraniol, which includes isolating and obtaining geraniol by culturing the aforementioned recombinant cells or by culturing the aforementioned geraniol-efficient synthetic strains. In some embodiments of the present invention, the aforementioned geraniol is obtained by microbial fermentation. The purity of the obtained geraniol is 90% or higher, preferably 95% or higher, and more preferably 98% or higher. The higher the purity of geraniol, the less likely impurities from the raw materials will be introduced during the preparation of α-tocotrienol. This results in a higher purity of the prepared α-tocotrienol.

[0065] On the other hand, this disclosure provides a method for preparing α-tocotrienols, wherein the α-tocotrienols are prepared using geraniol obtained according to the aforementioned method as a raw material. Compared with synthesis using commercially available geraniol (purity 85%), the method of this disclosure improves the purity of the raw materials used while reducing the cost of obtaining the raw materials, and can achieve the acquisition of tocotrienols with a single configuration, especially α-tocotrienols with a wider range of applications.

[0066] On the other hand, this disclosure provides an efficient method for obtaining α-tocotrienols from bio-based geraniol via a two-step Lewis acid-catalyzed reaction, comprising:

[0067] (1) Geraniol was prepared by the aforementioned method and reacted with trimethylhydroquinone in a first contact reaction to obtain a chain product after a Friedel-Crafts reaction catalyzed by a Lewis acid;

[0068] (2) The chain product and an aqueous solution of sodium dithionite are subjected to a second contact reaction to obtain the reduced phenol;

[0069] (3) The reduced phenol was cyclized under the catalysis of Lewis acid to obtain α-tocotrienol.

[0070] In some embodiments, the Lewis acid used in the first contact reaction is selected from one or more of zinc chloride, boron trifluoride ether, methyl aluminum chloride, p-toluenesulfonic acid, bis(trifluoromethanesulfonyl)imide, and hydrochloric acid.

[0071] In some embodiments, the amount of Lewis acid used in the first contact reaction is 5 mol% to 20 mol%.

[0072] In some embodiments, the equivalence ratio of geraniol to trimethylhydroquinone in the first contact reaction is 1:2 to 2:1.

[0073] In some embodiments, the reaction temperature of the first contact reaction is 40°C-80°C; preferably 50°C-60°C; more preferably 60°C, which is beneficial to improving the reaction yield.

[0074] In some embodiments, the solvent for the first contact reaction is selected from one or more of ethyl acetate, dichloromethane, 1,4-dioxane, tetrahydrofuran, toluene, DMA, DMF, chlorobenzene, and chloroform.

[0075] In some embodiments, the reducing agent for the second contact reaction is selected from hydrogen, sodium dithionite, sodium borohydride, and lithium aluminum hydride.

[0076] In some embodiments, the amount of reducing agent used in the second contact reaction is 5 to 20 equivalents.

[0077] In some embodiments, the solvent for the second contact reaction is selected from one or more of dichloromethane, ethyl acetate, methanol, diethyl ether, tetrahydrofuran, ethanol, dichloroethane, and 1,4-dioxane.

[0078] In some embodiments, the temperature of the third cyclization reaction is 50°C-100°C; preferably 60°C-80°C; more preferably 80°C.

[0079] In some embodiments, the Lewis acid used to catalyze the aforementioned third-step cyclization reaction is selected from one or more of zinc chloride, aluminum chloride, boron trifluoride ether, methyl aluminum chloride, p-toluenesulfonic acid, and bis(trifluoromethanesulfonyl)imide.

[0080] In some embodiments, the solvent for the third cyclization reaction is selected from one or more of ethyl acetate, dichloromethane, 1,4-dioxane, tetrahydrofuran, toluene, DMA, DMF, chlorobenzene, chloroform, n-hexane, and n-heptane.

[0081] In some embodiments of the present invention, the yield and purity of the chain oxidation product obtained by the first step reaction are very high; then the chain oxidation product is reduced in the presence of an aqueous solution of sodium dithionite to obtain the corresponding phenol, which is then directly fed into the next step to obtain the cyclized product α-tocotrienol under the catalysis of Lewis acid.

[0082] The embodiments of this disclosure are described in detail below. The embodiments described below are exemplary and are only used to explain this disclosure, and should not be construed as limiting this disclosure.

[0083] Where specific techniques or conditions are not specified in the examples, they shall be performed in accordance with the techniques or conditions described in the literature in this field or in accordance with the product instructions. Reagents or instruments whose manufacturers are not specified are all commercially available conventional products.

[0084] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of this disclosure. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0085] Example

[0086] Example 1: Functional identification of geranyl geraniol synthase from *Clostridium spp.*

[0087] To identify the chimeric bifunctional terpene synthase PTTC066 derived from *Clostridium spp.*, which can convert isopentenyl pyrophosphate (IPP) and dimethyl allyl pyrophosphate (DMAPP) to geraniol (GGOH), the function of PTTC066 was verified by in vitro reactions.

[0088] Given that PTTC066 contains a carboxyl-terminal isopentenyltransferase domain and an amino-terminal terpene cyclase domain, it is presumed that its isopentenyltransferase domain can convert DMAPP and IPP into gerany-gerany-pyrophosphate (GGPP), and its terpene cyclase domain can convert GGPP into GGOH. Notably, the carboxyl terminus of the terpene cyclase domain contains an arginine-tyrosine amino acid residue dimer. Therefore, PTTC066 is cleaved with arginine-tyrosine amino acid residue dimers, yielding 066PT (1..339) and 066TC (340..718).

[0089] Using the synthesized PTTC066 gene (SEQ ID NO.2) as a template, the fragment 066PT was amplified with primers 066PT-F / R, and then digested with restriction endonucleases NdeI and XhoI. Finally, it was ligated with the universal protein expression vector plasmid pET28a, which was digested with the same restriction endonucleases, to obtain the recombinant plasmid pET28a-066PT.

[0090] Using the synthesized PTTC066 gene (SEQ ID NO.2) as a template, the fragment 066TC was amplified with primers 066TC-F / R, and then digested with restriction endonucleases NcoI and XhoI. Finally, it was ligated with the universal protein expression vector plasmid pET28a, which was digested with the same restriction endonucleases, to obtain the recombinant plasmid pET28a-066TC.

[0091] The primers used and their sequences are shown in Table 1.

[0092] Table 1

[0093]

[0094] The recombinant plasmids pET28a-066PT and pET28a-066TC were transformed into Escherichia coli BL21(DE3) to obtain strains E-066PT and E-066TC.

[0095] Strains E-066PT and E-066TC were inoculated into 10 mL of LB liquid medium (with an additional 1‰ kanamycin) and cultured overnight at 37°C and 220 rpm. The next day, they were transferred to 1 L of LB liquid medium (with an additional 1‰ kanamycin) at a 1% inoculation rate and cultured at 37°C and 220 rpm until OD600 = 0.6-0.8. The temperature was lowered to 16°C, and 0.1 mM of the inducer isopropyl-β-D-thiogalactoside (IPTG) was added. The culture was then carried out at 16°C and 220 rpm for 16-18 h. The cells were collected by centrifugation at 8,000 rpm for 5 min. The cells were thoroughly resuspended in 30-40 mL of buffer A (50 mM Tris, 300 mM NaCl, 4 mM β-mercaptoethanol) and sonicated in an ice bath (pulse on 5 s, pulse off 8 s, 5 min). Centrifuge at 12,000g for at least 30 minutes at 4°C, and collect the supernatant. Then filter through a 0.45μm filter membrane, adjust the imidazole concentration in the liquid to approximately 30mM, and mix well. Purify the above liquid using the AKTA rapid protein purification system to obtain purified 066PT and 066TC protein solutions.

[0096] To test the in vitro activity of PTTC066, 10 μM purified protein (066TC or 066PT+066TC), 100 μM substrate (DMAPP+IPP or GGPP), and 2 mM Mg were used. 2+ Incubate overnight at 30°C in 200 μL of 50 mM phosphate buffer (pH 7.6) and 10% glycerol. Extract the sample with hexane (600 μL) and then analyze by LC-ESI-HRMS.

[0097] like Figure 1 As shown, 066TC can synthesize GGOH using GGPP as a substrate, and the co-addition of 066PT and 066TC can synthesize GGOH using DMAPP / IPP. This demonstrates that PTTC066 is a chimeric bifunctional terpene synthase capable of directly synthesizing GGOH using DMAPP and IPP as substrates.

[0098] Example 2: Construction of a high-yield geraniol strain

[0099] 2.1 Construction of high-yield plasmids

[0100] Using primers 003-1F / R, 003-2F / R, 003-3F / R, 003-4F / R, 003-5F / R, 003-6F / R, 003-7F / R, 003-8F / R, and 003-9F / R, fragments were amplified using 30000B, 30000B, PTTC066 gene synthesis, 30000B, 30000B, 30000B, 30000B, 30000B, and pRS426 as templates to obtain the X-4 left homologous arm, ADH1 terminator, PTTC066 gene, GAL1-GAL10 promoter, BTS1 gene, ERG20 gene, CPS1 terminator, X-4 right homologous arm, and plasmid backbone. Subsequently, using yeast assembly methods, these fragments were recombined in *Saccharomyces cerevisiae* to construct pHM003. See the schematic diagram of plasmid pHM003 construction. Figure 2 The primers used and their sequences are shown in Table 2.

[0101] Table 2

[0102]

[0103]

[0104] Using primers 004-1F / R, 004-2F / 003-2R, 003-3F / R, 003-4F / R, 003-5F / R, 003-6F / R, 003-7F / 004-7R, 004-8F / R, and 004-9F / R, fragments XI-1 (left homologous arm), ADH1 terminator, PTTC066 gene, GAL1-GAL10 promoter, BTS1 gene, ERG20 gene, CPS1 terminator, XI-1 (right homologous arm), and plasmid backbone were amplified using 30000B, 30000B, PTTC066 gene synthesis, 30000B, 30000B, 30000B, 30000B, and pRS426 as templates, respectively. Subsequently, using yeast assembly methods, these fragments were recombined in *Saccharomyces cerevisiae* to construct pHM004. See the schematic diagram of plasmid pHM004 construction. Figure 2 The primers used and their sequences are shown in Table 3.

[0105] Table 3

[0106]

[0107] Using primers 005-1F / R, 005-2F / 003-2R, 003-3F / R, 003-4F / R, 003-5F / R, 003-6F / R, 003-7F / 005-7R, 005-8F / R, and 005-9F / R, fragment XII-5 was amplified using 30000B, 30000B, PTTC066 synthetic gene, 30000B, 30000B, 30000B, 30000B, 30000B, and pRS426 as templates to obtain the left homologous arm of fragment XII-5, the ADH1 terminator, the PTTC066 gene, the GAL1-GAL10 promoter, the BTS1 gene, the ERG20 gene, the CPS1 terminator, the right homologous arm of fragment XII-5, and the plasmid backbone. Subsequently, using yeast assembly methods, the above fragments were recombined in *Saccharomyces cerevisiae* to construct pHM005. A schematic diagram of plasmid pHM005 construction is shown below. Figure 2 The primers used and their sequences are shown in Table 4.

[0108] Table 4

[0109]

[0110] 2.2 Construction of gene editing plasmids

[0111] The fragment was amplified using primer X-4_scaffold F / pKIURA3-R-common with pKlURA100 as a template. Then, using the Goldengate method, the fragment and pCAS were assembled to construct the plasmid pCRISPR001 (pKlURA100 and pCAS are referenced in Zhang, Yueping et al. “A gRNA-tRNA array for CRISPR-Cas9-based rapid multiplexed genome editing in Saccharomyces cerevisiae.” Nature Communications vol.10, 1 1053.5 Mar.2019, doi:10.1038 / s41467-019-09005-3). The primers used and their sequences are shown in Table 5.

[0112] Table 5

[0113]

[0114] The fragment was amplified using primers X-4_scaffold F / scaffold R and tGly F / tGly_XI-1R with pKlURA100 as a template. Then, using the fragment obtained with X-4_scaffold F and tGly_XI-1R as a template, overlap extension PCR was performed to obtain scaffold fragment 1. The fragment was then amplified using primer XI-1_scaffold F / pKIURA3-R-common with pKlURA100 as a template. Subsequently, the above fragments and pCAS were assembled using the Goldengate method to construct the plasmid pCRISPR002. The primers used and their sequences are shown in Table 6.

[0115] Table 6

[0116]

[0117] Fragments were amplified using primers X-4_scaffold F / tGly_XI-1R, XI-1_scaffold F / tGly_XII-5R, and XII-5_scaffold F / pKIURA3-R-common as templates for pCRISPR002, pCRISPR002, and pKlURA100. These fragments were then assembled with pCAS using the Goldengate method to construct the plasmid pCRISPR003. The primers used and their sequences are shown in Table 7.

[0118] Table 7

[0119]

[0120]

[0121] 2.3 Knockout Box Construction

[0122] Fragments were amplified using primers 34-1F / R, 34-2F / R, and 34-3F / R with 30000B, pRS423, and 30000B as templates. Subsequently, overlap extension PCR was performed using the fragments obtained with primers 34-1F and 34-3R as templates to obtain the pHM034 knockout cassette. A schematic diagram of the pHM034 knockout cassette construction is shown below. Figure 3 The primers used and their sequences are shown in Table 8.

[0123] Table 8

[0124]

[0125] Fragments were amplified using primers 35-1F / R, 35-2F / R, and 35-3F / R with 30000B, pRS426, and 30000B as templates. Subsequently, overlap extension PCR was performed using the fragments obtained with primers 35-1F and 35-3R as templates to obtain the pHM042 knockout cassette. A schematic diagram of the pHM042 knockout cassette construction is shown below. Figure 3 The primers used and their sequences are shown in Table 9.

[0126] Table 9

[0127]

[0128] Using primers 21-1F / 21-1Rn, 21-2Fn / 21-2R, 21-3F / R, 21-4F / R, 21-5F / 21-5Rn, and 21-6Fn / 21-6R, fragments were amplified using 30000B, pRS426, pRS424, pRS425, pRS423, and 30000B as templates, respectively. Subsequently, overlap extension PCR was performed using the fragments obtained with primers 21-1F and 21-6R as templates to obtain the pHM021 knockout cassette. A schematic diagram of the pHM021 knockout cassette construction is shown below. Figure 3 The primers used and their sequences are shown in Table 10.

[0129] Table 10

[0130]

[0131]

[0132] 2.4 Strain Construction

[0133] Plasmid pHM003 was linearized using MssI and then integrated into strain JCR27 using CRISPR plasmid pCRISPR001. After 5-FOA screening, strain JGGOH01 was obtained. Plasmids pHM003 and pHM004 were linearized using MssI and then integrated into strain JCR27 using CRISPR plasmid pCRISPR002. After 5-FOA screening, strain JGGOH02 was obtained. Plasmids pHM003, pHM004, and pHM005 were linearized using MssI and then integrated into strain JCR27 using CRISPR plasmid pCRISPR003. After 5-FOA screening, strain JGGOH03 was obtained. The pHM034 knockout cassette was then transferred into strain JGGOH03 to obtain strain JGGOH04. The pHM042 knockout kit was transferred into strain JGGOH04 to obtain strain JGGOH05. The pHM021 knockout kit was transferred into strain JGGOH05 to obtain strain JGGOH06.

[0134] 2.5 strain fermentation

[0135] Strains JGGOH01, JGGOH02, JGGOH03, JGGOH04, JGGOH05, and JGGOH06 were inoculated into YPD liquid medium and cultured overnight at 30°C and 220 rpm. The next day, they were transferred to 45 ml of YPDHG liquid medium (JGGOH01, JGGOH02, JGGOH03, JGGOH04, JGGOH05) or YPD liquid medium (JGGOH06) at an initial OD600 of 0.1, with 5 ml of n-dodecane added, and cultured at 30°C and 220 rpm for 72 hours. After fermentation, the organic layer was collected, centrifuged to remove impurities, and then analyzed using an analytical HPLC Dionex Ultimate 3000 with a C18 column (Waters Xterra RP18, 150 mm × 3.9 mm, 5 μm) and a UV absorbance detector monitored at 210 nm. The mobile phase was a mixture of methanol and water in a ratio of 80:20 (v / v), and the flow rate was 1 mL / min. The column temperature was set at 20 °C. The yield improvement results are shown in Table 11.

[0136] Table 11. Effects of iterative modification strategies on GGOH production in yeast strains

[0137] mutant strain culture medium Production increase JGGOH01 YPDHG 100.00％ JGGOH02 YPDHG 129.79％ JGGOH03 YPDHG 148.11％ JGGOH04 YPDHG 165.57％ JGGOH05 YPDHG 193.76％ JGGOH06 YPD 402.41％

[0138] Example 3: Comparison of yields of different homologous nucleotide sequences

[0139] Following the steps described in Example 2 for constructing plasmid pHM003-005 and strain JGGOH03, only the gene encoding the synthesis of geranyl geranyl synthase (SEQ ID NO:1) (SEQ ID NO:2) was replaced with the gene encoding the synthesis of geranyl geranyl synthase mutants (SEQ ID NO:3-61 (odd numbers)) (SEQ ID NO:4-62 (even numbers)). The resulting positive strains were named JGGOH07-JGGOH43. The location and type of mutations in the mutants of each strain are shown in Table 12.

[0140] Strains JGGOH03 and JGGOH07–JGGOH43 were inoculated into 5 mL of seed culture medium (peptone (20 g / L), yeast extract (10 g / L), glucose (20 g / L)) and cultured at 30 °C and 200 rpm for 20–24 h. Then, they were transferred to 45 mL of fermentation medium (peptone (20 g / L), yeast extract (10 g / L), glucose (10 g / L), galactose (10 g / L)) at a final OD600 of 0.1. After transfer, the medium was covered with 5 mL of organic phase (n-hexane) and fermented at 30 °C and 200 rpm for 72 h. The yield of geraniol in the fermentation broth was determined using the same HPLC method as in Example 2, and the yield ratio of geraniol in yeast strains expressing different mutants to that in yeast strains expressing wild-type enzymes was calculated (experimental group / control group). The results are shown in Table 12.

[0141] Table 12 Geraniol synthase mutants and related strains activity parameters

[0142]

[0143]

[0144] Example 4: Comparison of yields of different homologous nucleotide sequences

[0145] Based on the amino acid sequence of the wild-type enzyme (SEQ ID NO:1), a series of new mutants were designed. The design of these new mutant sequences used identity as an indicator, where identity adjustments were achieved through amino acid residue substitutions, and the mutation sites listed in Table 2 were not involved in the identity adjustment process. The amino acid sequences of the new mutants are shown in SEQ ID NO:63-77 (odd numbers), and the nucleotide sequences are shown in SEQ ID NO:64-78 (even numbers).

[0146] Following the steps described in Example 2 for constructing plasmid pHM003-005 and strain JGGOH03, only the gene encoding geraniol synthase was replaced to obtain a positive strain. After fermentation, the difference in geraniol yield relative to the wild type was compared, and the results are shown in Table 13.

[0147] Table 13 Comparison of the activities of homologous amino acid sequences with different identities

[0148] identity Designed amino acid sequence Optimized nucleotide sequence Yield ratio compared to wild type 95.13％ SEQ ID NO.63 SEQ ID NO.64 1.02 93.05％ SEQ ID NO.65 SEQ ID NO.66 0.95 91.10％ SEQ ID NO.67 SEQ ID NO.68 0.98 89.01％ SEQ ID NO.69 SEQ ID NO.70 0.97 87.07％ SEQ ID NO.71 SEQ ID NO.72 0.9 85.12％ SEQ ID NO.73 SEQ ID NO.74 1.07 83.03％ SEQ ID NO.75 SEQ ID NO.76 0.95 81.08％ SEQ ID NO.77 SEQ ID NO.78 0.12

[0149] As shown in Table 13, when the coding sequence of wild-type geraniol synthase is adjusted for identity, and the identity ratio reaches more than 83%, the catalytic activity of the obtained geraniol synthase is not significantly different from that of wild-type geraniol synthase, and it has good robustness.

[0150] Example 5: Fermentation of high-yield geraniol strain in fermenter

[0151] The pHM034, pHM042, and pHM021 knockout boxes were sequentially transferred into the strain JGGOH42, which had the highest yield, to obtain strain JGGOH101. Following the fermenter culture medium described in the literature (Ye Z, Huang Y, Shi B, et al. Coupling cell growth and biochemical pathway induction in Saccharomyces cerevisiae for production of (+)-valencene and its chemical conversion to (+)-nootkatone [published online ahead of print, 2022 Mar 13]. Metab Eng. 2022;72:107-115. doi:10.1016 / j.ymben.2022.03.005), the constructed strain JGGOH101 was subjected to fed-batch fermentation. During fermentation, a covering agent, n-dodecane, was added to achieve in-situ extraction. During fermentation, dissolved oxygen was controlled at above 20%, pH at 5, glucose concentration at 1-2 g / L, and ethanol concentration at below 5 g / L. Ultimately, the yield of geraniol reached 15.32 g / L in a 1 L fermenter.

[0152] Example 6: Purification of biogenic geraniol (GGOH)

[0153] After fermentation, the bacterial culture was centrifuged at 10,000 rpm for 10 minutes to remove cell debris. Then, the oil layer of n-dodecane was collected from the culture medium using a separation funnel. The product and n-dodecane were separated by vacuum distillation using a 0.6 m distillation column packed with 4 mm × 4 mm Dixon rings. The structure and purity of the product were determined by nuclear magnetic resonance (NMR) and gas chromatography-mass spectrometry (GC-MS). This process yielded a yellow oily GGOH in 86% yield with a purity exceeding 95%. NMR results are shown below. Figure 4 , Figure 5 As shown.

[0154] Example 7: Synthesis of 2,3,6-trimethyl-5-[(2E,6E,10E)-3,7,11,15-tetramethylhexadec-2,6,10,14-tetraenyl]benzene-1,4-dione from bio-derived geraniol.

[0155] Geraniol (852.2 mg) of biological origin was added to a reaction flask, followed by 10 mL of ethyl acetate, 10 mL of 1,4-dioxane, trimethylhydroquinone (922.4 mg), and boron trifluoride diethyl ether (0.2 mL). The mixture was heated to 60 °C and stirred under a nitrogen atmosphere. After reacting for 4 h, saturated ammonium chloride was added to quench the reaction. The mixture was then extracted with ethyl acetate, concentrated under reduced pressure, and separated by silica gel column chromatography to obtain the target product.

[0156] Geraniol (1.534 g) of biological origin was added to a reaction flask, followed by 50 mL of ethyl acetate, 2.021 g of trimethylhydroquinone, and 0.5 mL of boron trifluoride diethyl ether. The mixture was heated to 60 °C and stirred under a nitrogen atmosphere. After reacting for 4 h, saturated ammonium chloride was added to quench the reaction. The mixture was then extracted with ethyl acetate, concentrated under reduced pressure, and separated by silica gel column chromatography to obtain the target product.

[0157] Geraniol (922.2 mg) of biological origin was added to a reaction flask, followed by 10 mL of ethyl acetate, 10 mL of 1,4-dioxane, trimethylhydroquinone (812.4 mg), and boron trifluoride diethyl ether (0.2 mL). The mixture was heated to 60 °C and stirred under a nitrogen atmosphere. After reacting for 4 h, saturated ammonium chloride was added to quench the reaction. The mixture was then extracted with ethyl acetate, concentrated under reduced pressure, and separated by silica gel column chromatography to obtain the target product.

[0158] Geraniol (10 g) of biological origin was added to a reaction flask, and 150 mL of 1,4-dioxane, trimethylhydroquinone (8.5 g), and boron trifluoride diethyl ether (3 mL) were added to the system. The mixture was heated to 80 °C and stirred under a nitrogen atmosphere. After reacting for 4 h, saturated ammonium chloride was added to quench the reaction. The mixture was extracted with ethyl acetate, concentrated under reduced pressure, and separated by silica gel column chromatography to obtain the target product.

[0159] Example 8: Reduction of 2,3,6-trimethyl-5-[(2E,6E,10E)-3,7,11,15-tetramethylhexadec-2,6,10,14-tetraenyl]benzene-1,4-dione

[0160] The compound obtained in Example 8 (633.5 mg) was added to a reaction flask, along with an aqueous solution of sodium dithionite (50% w / w, 10 mL) and dichloromethane as the solvent. The mixture was stirred at room temperature and reacted overnight. After concentration under reduced pressure, the crude product was directly used in the next step.

[0161] The compound obtained in Example 8 (1.257 mg) was added to a reaction flask, along with an aqueous solution of sodium dithionite (50% w / w, 30 mL) and dichloromethane as the solvent. The mixture was stirred at room temperature and reacted overnight. After concentration under reduced pressure, the crude product was directly used in the next step.

[0162] The compound obtained in Example 8 (535.5 mg) was added to a reaction flask, along with an aqueous solution of sodium dithionite (50% w / w, 10 mL) and dichloromethane as the solvent. The mixture was stirred at room temperature and reacted overnight. After concentration under reduced pressure, the crude product was directly used in the next step.

[0163] The compound (6.9 g) obtained in Example 8 was added to a reaction flask, along with an aqueous solution of sodium dithionite (50% w / w, 100 mL) and ethyl acetate as the solvent. The mixture was stirred at room temperature and reacted overnight. After concentration under reduced pressure, the crude product was obtained and used directly in the next step.

[0164] The compound obtained in Example 8 (5.5 g) was added to a reaction flask, along with sodium borohydride (0.7566 g) and methanol as the solvent. The mixture was stirred at room temperature and reacted overnight. After concentration under reduced pressure, the crude product was obtained and used directly in the next step.

[0165] The compound obtained in Example 8 (253.8 mg) was added to a reaction flask, along with sodium borohydride (35 mg) and methanol as the solvent. The mixture was stirred at room temperature and reacted overnight. After concentration under reduced pressure, the crude product was directly used in the next step.

[0166] Example 9: Synthesis of α-Tocotrienol

[0167] The crude product obtained from the reduction in Example 8 was immediately placed under a nitrogen atmosphere, and n-hexane was added as a solvent. After adding p-toluenesulfonic acid (10 mol%), the mixture was stirred at 80°C overnight. The resulting system was purified by silica gel column chromatography to obtain the target product, α-tocotrienol. The NMR results of the target product are as follows: Figure 6 , Figure 7 As shown.

[0168] The crude product obtained from the reduction in Example 8 was immediately placed under a nitrogen atmosphere, toluene was added as a solvent, p-toluenesulfonic acid (10 mol%) was added, and the mixture was stirred at 80°C overnight. After purification by silica gel column chromatography, the target product α-tocotrienol was obtained.

[0169] The crude product obtained from the reduction in Example 8 was immediately placed under a nitrogen atmosphere, and n-hexane was added as a solvent. After adding methyl aluminum chloride (10 mol%), the mixture was stirred at 80°C overnight. The system was then purified by silica gel column chromatography to obtain the target product with a yield of 33%.

[0170] The crude product obtained from the reduction in Example 8 was immediately placed under a nitrogen atmosphere, and n-heptane was added as a solvent. After adding p-toluenesulfonic acid (10 mmol%, 140 mg) and stirring at 60°C overnight, the system was purified by silica gel column chromatography to obtain the target product with a yield of 30%.

[0171] The crude product obtained from the reduction in Example 8 was immediately placed under a nitrogen atmosphere, and n-hexane was added as a solvent. After adding aluminum chloride (10 mol%), the mixture was stirred at 80°C overnight. The system was then purified by silica gel column chromatography to obtain the target product with a yield of 20%.

[0172] The gene sequences involved in this disclosure are as follows:

[0173] >SEQ ID NO.1

[0174] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTA

[0175] LVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQ

[0176] AKMMYQLARTDKRCAERVKRVWKTMLSTTLKHKSDSFASLEEYLNYRIIDTGGYWVESVMLFGMGMTL

[0177] TEEEDAQLAEVVRPCYASLALANDYFSFDREWEEAQNGGPPPTNAVWLYMRWNGIPMPAAKKLVREASN

[0178] RYEARFLELLCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARG

[0179] DGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDT

[0180] KHVAAPFDYVASLPSKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMFDDIEDGSELRRGNPAAH

[0181] AVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKT

[0182] GGLFKLISRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDFKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTK

[0183] GQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[0184] >SEQ ID NO.2

[0185] ATGTGTACTATGGATGATCATACATCTGAATTGTTGGATATCTCACAATTCGATACTCAAGGTTTCTGTCC

[0186] AGGTTATCCATTGAGAAGACATAGATACGAATCTTTAGCAAATTCAGGTTGTTATGAAGCTAGACAAGA

[0187] TTGGATTCATTACGTTGGTCCAGCTGAAGAATTTGGTTCTTGTGATCCAACTAACGGTAACTTCACAGC

[0188] ATTGGTTTTACCATTGACTAAACCAGAAAGATTGCATTTGGTTGCTTACATCATCGAGTGTGAGTTTATT

[0189] AGAGTTTGTACCCATACGCATTTTTGCATGATAATGTGTGTTGAAGCAGTTATGCCAGATTCTTCAACAA

[0190] ACAACGTGACGATTTCCATTTGGGTGAAGCTGAAAAGAGACAAAGAAACGTTAGAATGGGTAGAAA

[0191] GCAAATCCAAGCAAAGATGATGTACCAATTGGCTAGAACTGATAAGAGATGTGCAGAAAGAGTTAAGA

[0192] GAGTTTGGAAGACAATGTTGTCTACTACATTGAAGCATAAGTCAGATTCTTTCGCATCATTGGAAGAATA

[0193] TTTGAACTACAGAATCATCGATACTGGTGGTTACTGGGTTGAATCTGTTATGTTGTTTGGTATGGGTATG

[0194] ACTTTAACAGAAGAAGAAGATGCTCAATTGGCAGAAGTTGTTAGACCATGTTATGCTTCTTTAGCTTTG

[0195] GCAAACGATTACTTCTCATTCGATAGAGAATGGGAAGAAGCTCAAAATGGTGGTCCACCACCAACAAA

[0196] TGCAGTTGGTTGTATATGAGATGGAATGGTATTCCAATGCCAGCTGCTAAGAAATTGGTTAGAGAAGC

[0197] ATCTAACAGATACGAAGCTAGATTTTTAGAATTGTGTGATTCTTTTAGAAGAAACAACCCATTGTACTCA

[0198] GAAAAATTGGATAAATATTTGAGAGGTTTGGCTTACCAAAATTTCTGGTAATGTTGTTTGGTCATTGACTT

[0199] GTCCAAGATATCATCCAGAGTTTAGATACGATCCAAATGCTGGTATGGAAGATTTGTTAACTGCTCAAGC

[0200] TAGAGGTGACGGTGGTGCTGTTTCTGGTGGTGAAGCTGATTACACAGCAGAACATAGACAATCAATCA

[0201] TTTCTTTAGAATCACAACATACTGCTTCTTCAACAAGATATTCAGCATCTGATTGGCAATCTTCAAGATC

[0202] TTCATCTTTTTCTGAAATCTCAGTTGATGGTGAAGATGGTGAAACTCATGCAGTTAAATTGCCAGCTGA

[0203] ACAAGGTTTAGATACAAAACATGTTGCTGCACCATTTGATTATGTTGCTTCTTTGCCATCAAAGGGTGTT

[0204] AGAACTACATTGATCGATGCATTGAATTTGTGGTGTGATTTGCCAGATACTACATTGGCTGGTATTAAAG

[0205] AAGTTGTTGATAAATTGCATACAGCATCTTTAATGTTCGATGATATCGAAGATGGTTCAGAATTGAGAAG

[0206] AGGTAATCCAGCTGCACATGCAGTTTACGGTGTTCCACAAACTATTAATGCTGCATCTTTTGCTATTGTT

[0207] GATGCAGTTTCAAAAGCTCAAGATATTCCAGTTACAGGTGCTGTTGATATTGTTTTAGAACAATTGAGA

[0208] GATTTGCATATCGGTCAATCTTATGATATCCATTGGACTAGACATTCATCTTGTCCATCAGAAACAGAATA

[0209] CTTAGAAATGGTTGCTAAGAAAACTGGTGGTTTGTTTAAATTAATTTCTAGATTGATGACTACAGGTTTA

[0210] CCAGATATCACTAAATCAACAATCGATGATTTGGTTACACAATTGGGTATCTATTTCCAAATCAGAGATG

[0211] ATTTCAAGAATTTGAACTCTGATGAATACGCTTCACAAAAAGGTTTCTGTGAAGATTTGGATGAGGGTA

[0212] AATTTTCTTTCCCATTGGTTCATTATTTGACTAAAGGTCAAGAATCTCCACCTTTTATGTTGAGAGAAAT

[0213] CATGCAACAAAGAAGAGAATCTAAGGGTTTGAACGTTCCATCAAAGATGTTGGCTTTGCAACAATTGA

[0214] AGAAATCTGGTTCTTTAGAATACACTCATAGAACATTGAAGAGATTAGAAGTTCAAATTAATCAAATCAT

[0215] TGGTAGATTGGAAAGAATCACTGGTAAAGATAACTGGGTTTTGAGATTGTGTATGGGTGAATTAACAGT

[0216] TTGA

[0217] SEQ ID NO. 3

[0218] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGGCDPTNGNFTA

[0219] LVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQ

[0220] AKMMYQLARTDKRCAERVKRVWKTMLSTTLKHKSDSFASLEEYLNYRIIDTGGYWVESVMLFGMGMTL

[0221] TEEEDAQLAEVVRPCYASLALANDYFSFDREWEEAQNGGPPPTNAVWLYMRWNGIPMPAAKKLVREASN

[0222] RYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARG

[0223] DGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDT

[0224] KHVAAPFDYVASLPSKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMFDDIEDGSELRRGNPAAH

[0225] AVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKT

[0226] GGLFKLISRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDFKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTK

[0227] GQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[0228] >SEQ ID NO.4

[0229] ATGTGTACTATGGATGATCATACATCTGAATTGTTGGATATCTCACAATTCGATACTCAAGGTTTCTGTCC

[0230] AGGTTATCCATTGAGAAGACATAGATACGAATCTTTAGCAAATTCAGGTTGTTATGAAGCTAGACAAGA

[0231] TTGGATTCATTACGTTGGTCCAGCTGAAGAATTTGGTGGTTGTGATCCAACTAACGGTAACTTCACAGC

[0232] ATTGGTTTTACCATTGACTAAACCAGAAAGATTGCATTTGGTTGCTTACATCATCGAGTGTGAGTTTATT

[0233] AGAGTTTTGTACCCATACGCATTTTTGCATGATAATGTTGTTGAAGCAGTTATGCCAGATTCTTCAACAA

[0234] ACAACGGTGACGATTTCCATTTGGGTGAAGCTGAAAAGAGACAAAGAAACGTTAGAATGGGTAGAAA

[0235] GCAAATCCAAGCAAAGATGATGTACCAATTGGCTAGAACTGATAAGAGATGTGCAGAAAGAGTTAAGA

[0236] GAGTTTGGAAGACAATGTTGTCTACTACATTGAAGCATAAGTCAGATTCTTTCGCATCATTGGAAGAATA

[0237] TTTGAACTACAGAATCATCGATACTGGTGGTTACTGGGTTGAATCTGTTATGTTGTTTGGTATGGGTATG

[0238] ACTTTAACAGAAGAAGAAGATGCTCAATTGGCAGAAGTTGTTAGACCATGTTATGCTTCTTTAGCTTTG

[0239] GCAAACGATTACTTCTCATTCGATAGAGAATGGGAAGAAGCTCAAAATGGTGGTCCACCACCAACAAA

[0240] TGCAGTTTGGTTGTATATGAGATGGAATGGTATTCCAATGCCAGCTGCTAAGAAATTGGTTAGAGAAGC

[0241] ATCTAACAGATACGAAGCTAGATTTTTAGAATTGTGTGATTCTTTTAGAAGAAACAACCCATTGTACTCA

[0242] GAAAAATTGGATAAATATTTGAGAGGTTTGGCTTACCAAATTTCTGGTAATGTTGTTTGGTCATTGACTT

[0243] GTCCAAGATATCATCCAGAGTTTAGATACGATCCAAATGCTGGTATGGAAGATTTGTTAACTGCTCAAGC

[0244] TAGAGGTGACGGTGGTGCTGTTTCTGGTGGTGAAGCTGATTACACAGCAGAACATAGACAATCAATCA

[0245] TTTCTTTAGAATCACAACATACTGCTTCTTCAACAAGATATTCAGCATCTGATTGGCAATCTTCAAGATC

[0246] TTCATCTTTTTCTGAAATCTCAGTTGATGGTGAAGATGGTGAAACTCATGCAGTTAAATTGCCAGCTGA

[0247] ACAAGGTTTAGATACAAAACATGTTGCTGCACCATTTGATTATGTTGCTTCTTTGCCATCAAAGGGTGTT

[0248] AGAACTACATTGATCGATGCATTGAATTTGTGGTGTGATTTGCCAGATACTACATTGGCTGGTATTAAAG

[0249] AAGTTGTTGATAAATTGCATACAGCATCTTTAATGTTCGATGATATCGAAGATGGTTCAGAATTGAGAAG

[0250] AGGTAATCCAGCTGCACATGCAGTTTACGGTGTTCCACAAACTATTAATGCTGCATCTTTTGCTATTGTT

[0251] GATGCAGTTTCAAAAGCTCAAGATATTCCAGTTACAGGTGCTGTTGATATTGTTTTAGAACAATTGAGA

[0252] GATTTGCATATCGGTCAATCTTATGATATCCATTGGACTAGACATTCATCTTGTCCATCAGAAACAGAATA

[0253] CTTAGAAATGGTTGCTAAGAAAACTGGTGGTTTGTTTAAATTAATTTCTAGATTGATGACTACAGGTTTA

[0254] CCAGATATCACTAAATCAACAATCGATGATTTGGTTACACAATTGGGTATCTATTTCCAAATCAGAGATG

[0255] ATTTCAAGAATTTGAACTCTGATGAATACGCTTCACAAAAAGGTTTCTGTGAAGATTTGGATGAGGGTA

[0256] AATTTTCTTTCCCATTGGTTCATTATTTGACTAAAGGTCAAGAATCTCCACCTTTTATGTTGAGAGAAAT

[0257] CATGCAACAAAGAAGAGAATCTAAGGGTTTGAACGTTCCATCAAAGATGTTGGCTTTGCAACAATTGA

[0258] AGAAATCTGGTTCTTTAGAATACACTCATAGAACATTGAAGAGATTAGAAGTTCAAATTAATCAAATCAT

[0259] TGGTAGATTGGAAAGAATCACTGGTAAAGATAACTGGGTTTTGAGATTGTGTATGGGTGAATTAACAGT

[0260] TTGA

[0261] SEQ ID NO. 5

[0262] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTA

[0263] LVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQ

[0264] AKMMYQLARTDKRCAERVKRVWKTMLSTTLRHKSDSFASLEEYLNYRIIDTGGYWVESVMLFGMGMTL

[0265] TEEEDAQLAEVVRPCYASLALANDYFSFDREWEEAQNGGPPPTNAVWLYMRWNGIPMPAAKKLVREASN

[0266] RYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARG

[0267] DGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDT

[0268] KHVAAPFDYVASLPSKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMFDDIEDGSELRRGNPAAH

[0269] AVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKT

[0270] GGLFKLISRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDFKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTK

[0271] GQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[0272] >SEQ ID NO.6

[0273] ATGTGTACTATGGATGATCATACATCTGAATTGTTGGATATCTCACAATTCGATACTCAAGGTTTCTGTCC

[0274] AGGTTATCCATTGAGAAGACATAGATACGAATCTTTAGCAAATTCAGGTTGTTATGAAGCTAGACAAGA

[0275] TTGGATTCATTACGTTGGTCCAGCTGAAGAATTTGGTTCTTGTGATCCAACTAACGGTAACTTCACAGC

[0276] ATTGGTTTTACCATTGACTAAACCAGAAAGATTGCATTTGGTTGCTTACATCATCATCGAGGTGTGAGTTTATT

[0277] AGAGTTTGTACCCATACGCATTTTTGCATGATAATGTGTGTTGAAGCAGTTATGCCAGATTCTTCAACAA

[0278] ACAACGTGACGATTTCCATTTGGGTGAAGCTGAAAAGAGACAAAGAAACGTTAGAATGGGTAGAAA

[0279] GCAAATCCAAGCAAAGATGATGTACCAATTGGCTAGAACTGATAAGAGATGTGCAGAAAGAGTTAAGA

[0280] GAGTTTGGAAGACAATGTTGTCTACTACATTGAGACATAAGTCAGATTCTTTCGCATCATTGGAAGAATA

[0281] TTTGAACTACAGAATCATCGATACTGGTGGTTACTGGGTTGAATCTGTTATGTTGTTTGGTATGGGTATG

[0282] ACTTTAACAGAAGAAGAAGATGCTCAATTGGCAGAAGTTGTTAGACCATGTTATGCTTCTTTAGCTTTG

[0283] GCAAACGATTACTTCTCATTCGATAGAGAATGGGAAGAAGCTCAAAATGGTGGTCCACCACCAACAAA

[0284] TGCAGTTTGGTTGTATATGAGATGGAATGGTATTCCAATGCCAGCTGCTAAGAAATTGGTTAGAGAAGC

[0285] ATCTAACAGATACGAAGCTAGATTTTTAGAATTGTGTGATTCTTTTAGAAGAAACAACCCATTGTACTCA

[0286] GAAAAATTGGATAAATATTTGAGAGGTTTGGCTTACCAAATTTCTGGTAATGTTGTTTGGTCATTGACTT

[0287] GTCCAAGATATCATCCAGAGTTTAGATACGATCCAAATGCTGGTATGGAAGATTTGTTAACTGCTCAAGC

[0288] TAGAGGTGACGGTGGTGCTGTTTCTGGTGGTGAAGCTGATTACACAGCAGAACATAGACAATCAATCA

[0289] TTTCTTTAGAATCACAACATACTGCTTCTTCAACAAGATATTCAGCATCTGATTGGCAATCTTCAAGATC

[0290] TTCATCTTTTTCTGAAATCTCAGTTGATGGTGAAGATGGTGAAACTCATGCAGTTAAATTGCCAGCTGA

[0291] ACAAGGTTTAGATACAAAACATGTTGCTGCACCATTTGATTATGTTGCTTCTTTGCCATCAAAGGGTGTT

[0292] AGAACTACATTGATCGATGCATTGAATTTGTGGTGTGATTTGCCAGATACTACATTGGCTGGTATTAAAG

[0293] AAGTTGTTGATAAATTGCATACAGCATCTTTAATGTTCGATGATATCGAAGATGGTTCAGAATTGAGAAG

[0294] AGGTAATCCAGCTGCACATGCAGTTTACGGTGTTCCACAAACTATTAATGCTGCATCTTTTGCTATTGTT

[0295] GATGCAGTTTCAAAAGCTCAAGATATTCCAGTTACAGGTGCTGTTGATATTGTTTTAGAACAATTGAGA

[0296] GATTTGCATATCGGTCAATCTTATGATATCCATTGGACTAGACATTCATCTTGTCCATCAGAAACAGAATA

[0297] CTTAGAAATGGTTGCTAAGAAAACTGGTGGTTTGTTTAAATTAATTTCTAGATTGATGACTACAGGTTTA

[0298] CCAGATATCACTAAATCAACAATCGATGATTTGGTTACACAATTGGGTATCTATTTCCAAATCAGAGATG

[0299] ATTTCAAGAATTTGAACTCTGATGAATACGCTTCACAAAAAGGTTTCTGTGAAGATTTGGATGAGGGTA

[0300] AATTTTCTTTCCCATTGGTTCATTATTTGACTAAAGGTCAAGAATCTCCACCTTTTATGTTGAGAGAAAT

[0301] CATGCAACAAAGAAGAGAATCTAAGGGTTTGAACGTTCCATCAAAGATGTTGGCTTTGCAACAATTGA

[0302] AGAAATCTGGTTCTTTAGAATACACTCATAGAACATTGAAGAGATTAGAAGTTCAAATTAATCAAATCAT

[0303] TGGTAGATTGGAAAGAATCACTGGTAAAGATAACTGGGTTTTGAGATTGTGTATGGGTGAATTAACAGT

[0304] TTGA

[0305] >SEQ ID NO.7

[0306] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTA

[0307] LVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQ

[0308] AKMMYQLARTDKRCAERVKRVWKTMLSTTLKDKSDSFASLEEYLNYRIIDTGGYWVESVMLFGMGMTL

[0309] TEEEDAQLAEVVRPCYASLALANDYFSFDREWEEAQNGGPPPTNAVWLYMRWNGIPMPAAKKLVREASN

[0310] RYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARG

[0311] DGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDT

[0312] KHVAAPFDYVASLPSKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMFDDIEDGSELRRGNPAAH

[0313] AVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKT

[0314] GGLFKLISRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDFKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTK

[0315] GQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[0316] >SEQ ID NO.8

[0317] ATGTGTACTATGGATGATCATACATCTGAATTGTTGGATATCTCACAATTCGATACTCAAGGTTTCTGTCC

[0318] AGGTTATCCATTGAGAAGACATAGATACGAATCTTTAGCAAATTCAGGTTGTTATGAAGCTAGACAAGA

[0319] TTGGATTCATTACGTTGGTCCAGCTGAAGAATTTGGTTCTTGTGATCCAACTAACGGTAACTTCACAGC

[0320] ATTGGTTTTACCATTGACTAAACCAGAAAGATTGCATTTGGTTGCTTACATCATCGAGTGTGAGTTTATT

[0321] AGAGTTTTGTACCCATACGCATTTTTGCATGATAATGTTGTTGAAGCAGTTATGCCAGATTCTTCAACAA

[0322] ACAACGGTGACGATTTCCATTTGGGTGAAGCTGAAAAGAGACAAAGAAACGTTAGAATGGGTAGAAA

[0323] GCAAATCCAAGCAAAGATGATGTACCAATTGGCTAGAACTGATAAGAGATGTGCAGAAAGAGTTAAGA

[0324] GAGTTTGGAAGACAATGTTGTCTACTACATTGAAGGATAAGTCAGATTCTTTCGCATCATTGGAAGAATA

[0325] TTTGAACTACAGAATCATCGATACTGGTGGTTACTGGGTTGAATCTGTTATGTTGTTTGGTATGGGTATG

[0326] ACTTTAACAGAAGAAGAAGATGCTCAATTGGCAGAAGTTGTTAGACCATGTTATGCTTCTTTAGCTTTG

[0327] GCAAACGATTACTTCTCATTCGATAGAGAATGGGAAGAAGCTCAAAATGGTGGTCCACCACCAACAAA

[0328] TGCAGTTTGGTTGTATATGAGATGGAATGGTATTCCAATGCCAGCTGCTAAGAAATTGGTTAGAGAAGC

[0329] ATCTAACAGATACGAAGCTAGATTTTTAGAATTGTGTGATTCTTTTAGAAGAAACAACCCATTGTACTCA

[0330] GAAAAATTGGATAAATATTTGAGAGGTTTGGCTTACCAAATTTCTGGTAATGTTGTTTGGTCATTGACTT

[0331] GTCCAAGATATCATCCAGAGTTTAGATACGATCCAAATGCTGGTATGGAAGATTTGTTAACTGCTCAAGC

[0332] TAGAGGTGACGGTGGTGCTGTTTCTGGTGGTGAAGCTGATTACACAGCAGAACATAGACAATCAATCA

[0333] TTTCTTTAGAATCACAACATACTGCTTCTTCAACAAGATATTCAGCATCTGATTGGCAATCTTCAAGATC

[0334] TTCATCTTTTTCTGAAATCTCAGTTGATGGTGAAGATGGTGAAACTCATGCAGTTAAATTGCCAGCTGA

[0335] ACAAGGTTTAGATACAAAACATGTTGCTGCACCATTTGATTATGTTGCTTCTTTGCCATCAAAGGGTGTT

[0336] AGAACTACATTGATCGATGCATTGAATTTGTGGTGTGATTTGCCAGATACTACATTGGCTGGTATTAAAG

[0337] AAGTTGTTGATAAATTGCATACAGCATCTTTAATGTTCGATGATATCGAAGATGGTTCAGAATTGAGAAG

[0338] AGGTAATCCAGCTGCACATGCAGTTTACGGTGTTCCACAAACTATTAATGCTGCATCTTTTGCTATTGTTGATGCAGTTTCAAAAGCTCAAGATATTCCAGTTACAGGTGCTGTTGATATTGTTTTAGAACAATTGAGAGATTTGCATATCGGTCAATCTTATGATATCCATTGG ACTAGACATTCATCTTGTCCATCAGAAACAGAATACTTAGAAATGGTTGCTAAGAAAACTGGTGGTTTGTTTAAATTAATTTCTAGATTGATGACTACAGGTTTACCAGATATCACTAAATCAACAATCGATGATTTGGTTACACAATTGGGTATCTATTTCCAAATCAGAGATG ATTTCAAGAATTTGAACTCTGATGAATACGCTTCACAAAAAGGTTTCTGTGAAGATTTGGATGAGGGTAAATTTTCTTTCCCATTGGTTCATTATTTGACTAAAGGTCAAGAATCTCCACCTTTTATGTTGAGAGAAATCATGCAACAAAGAAGAGAATCTAAGGGTTTGAACGTTCCATCAAAGATGTTGGCTTTGCAACAATTGAAGAAATCTGGTTCTTTAGAATACACTCATAGAACATTGAAGAGATTAGAAGTTCAAATTAATCAAATCAATCATTGGTAGATTGGAAAGAATCACTGGTAAAGATAACTGGGTTTTGAGATTGTGTATGGGTGAATTAACAGTTTGA

[0339] >SEQ ID NO.9

[0340] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTALVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQAKMMYQLARTDKRCAERVKRVWKTMLSTTLKHKSDSFASLEEYLNFRIIDTGGYWVESVMLFGMGMTLTEEEDAQLAEVVRPCYASLALANDYFSFDREWEEAQNGGPPPTNAVWLYMRWNGIPMPAAKKLVREASNRYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARGDGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDTKHVAAPFDYVASLPSKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMFDDIEDGSELRRGNPAAHAVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKTGGLFKLISRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDFKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTKGQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[0341] >SEQ ID NO.10

[0342]

[0343] >SEQ ID NO.11

[0344] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTA

[0345] LVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQ

[0346] AKMMYQLARTDKRCAERVKRVWKTMLSTTLKHKSDSFASLEEYLNYRIIDTGAYWVESVMLFGMGMTL

[0347] TEEEDAQLAEVVRPCYASLALANDYFSFDREWEEAQNGGPPPTNAVWLYMRWNGIPMPAAKKLVREASN

[0348] RYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARG

[0349] DGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDT

[0350] KHVAAPFDYVASLPSKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMFDDIEDGSELRRGNPAAH

[0351] AVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKT

[0352] GGLFKLISRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDFKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTK

[0353] GQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[0354] SEQ ID NO. 12

[0355] ATGTGTACTATGGATGATCATACATCTGAATTGTTGGATATCTCACAATTCGATACTCAAGGTTTCTGTCC

[0356] AGGTTATCCATTGAGAAGACATAGATACGAATCTTTAGCAAATTCAGGTTGTTATGAAGCTAGACAAGA

[0357] TTGGATTCATTACGTTGGTCCAGCTGAAGAATTTGGTTCTTGTGATCCAACTAACGGTAACTTCACAGC

[0358] ATTGGTTTTACCATTGACTAAACCAGAAAGATTGCATTTGGTTGCTTACATCATCATCGAGGTGTGAGTTTATT

[0359] AGAGTTTGTACCCATACGCATTTTTGCATGATAATGTGTGTTGAAGCAGTTATGCCAGATTCTTCAACAA

[0360] ACAACGTGACGATTTCCATTTGGGTGAAGCTGAAAAGAGACAAAGAAACGTTAGAATGGGTAGAAA

[0361] GCAAATCCAAGCAAAGATGATGTACCAATTGGCTAGAACTGATAAGAGATGTGCAGAAAGAGTTAAGA

[0362] GAGTTTGGAAGACAATGTTGTCTACTACATTGAAGCATAAGTCAGATTCTTTCGCATCATTGGAAGAATA

[0363] TTTGAACTACAGAATCATCGATACTGGTGCTTACTGGGTTGAATCTGTTATGTTGTTTGGTATGGGTATG

[0364] ACTTTAACAGAAGAAGAAGATGCTCAATTGGCAGAAGTTGTTAGACCATGTTATGCTTCTTTAGCTTTG

[0365] GCAAACGATTACTTCTCATTCGATAGAGAATGGGAAGAAGCTCAAAATGGTGGTCCACCACCAACAAA

[0366] TGCAGTTTGGTTGTATATGAGATGGAATGGTATTCCAATGCCAGCTGCTAAGAAATTGGTTAGAGAAGC

[0367] ATCTAACAGATACGAAGCTAGATTTTTAGAATTGTGTGATTCTTTTAGAAGAAACAACCCATTGTACTCA

[0368] GAAAAATTGGATAAATATTTGAGAGGTTTGGCTTACCAAATTTCTGGTAATGTTGTTTGGTCATTGACTT

[0369] GTCCAAGATATCATCCAGAGTTTAGATACGATCCAAATGCTGGTATGGAAGATTTGTTAACTGCTCAAGC

[0370] TAGAGGTGACGGTGGTGCTGTTTCTGGTGGTGAAGCTGATTACACAGCAGAACATAGACAATCAATCA

[0371] TTTCTTTAGAATCACAACATACTGCTTCTTCAACAAGATATTCAGCATCTGATTGGCAATCTTCAAGATC

[0372] TTCATCTTTTTCTGAAATCTCAGTTGATGGTGAAGATGGTGAAACTCATGCAGTTAAATTGCCAGCTGA

[0373] ACAAGGTTTAGATACAAAACATGTTGCTGCACCATTTGATTATGTTGCTTCTTTGCCATCAAAGGGTGTT

[0374] AGAACTACATTGATCGATGCATTGAATTTGTGGTGTGATTTGCCAGATACTACATTGGCTGGTATTAAAG

[0375] AAGTTGTTGATAAATTGCATACAGCATCTTTAATGTTCGATGATATCGAAGATGGTTCAGAATTGAGAAG

[0376] AGGTAATCCAGCTGCACATGCAGTTTACGGTGTTCCACAAACTATTAATGCTGCATCTTTTGCTATTGTT

[0377] GATGCAGTTTCAAAAGCTCAAGATATTCCAGTTACAGGTGCTGTTGATATTGTTTTAGAACAATTGAGA

[0378] GATTTGCATATCGGTCAATCTTATGATATCCATTGGACTAGACATTCATCTTGTCCATCAGAAACAGAATA

[0379] CTTAGAAATGGTTGCTAAGAAAACTGGTGGTTTGTTTAAATTAATTTCTAGATTGATGACTACAGGTTTA

[0380] CCAGATATCACTAAATCAACAATCGATGATTTGGTTACACAATTGGGTATCTATTTCCAAATCAGAGATG

[0381] ATTTCAAGAATTTGAACTCTGATGAATACGCTTCACAAAAAGGTTTCTGTGAAGATTTGGATGAGGGTA

[0382] AATTTTCTTTCCCATTGGTTCATTATTTGACTAAAGGTCAAGAATCTCCACCTTTTATGTTGAGAGAAAT

[0383] CATGCAACAAAGAAGAGAATCTAAGGGTTTGAACGTTCCATCAAAGATGTTGGCTTTGCAACAATTGA

[0384] AGAAATCTGGTTCTTTAGAATACACTCATAGAACATTGAAGAGATTAGAAGTTCAAATTAATCAAATCAT

[0385] TGGTAGATTGGAAAGAATCACTGGTAAAGATAACTGGGTTTTGAGATTGTGTATGGGTGAATTAACAGT

[0386] TTGA

[0387] >SEQ ID NO.13

[0388] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTA

[0389] LVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQ

[0390] AKMMYQLARTDKRCAERVKRVWKTMLSTTLKHKSDSFASLEEYLNYRIIDTGGPWVESVMLFGMGMTL

[0391] TEEEDAQLAEVVRPCYASLALANDYFSFDREWEEAQNGGPPPTNAVWLYMRWNGIPMPAAKKLVREASN

[0392] RYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARG

[0393] DGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDT

[0394] KHVAAPFDYVASLPSKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMFDDIEDGSELRRGNPAAH

[0395] AVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKT

[0396] GGLFKLISRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDFKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTK

[0397] GQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[0398] >SEQ ID NO.14

[0399] ATGTGTACTATGGATGATCATACATCTGAATTGTTGGATATCTCACAATTCGATACTCAAGGTTTCTGTCC

[0400] AGGTTATCCATTGAGAAGACATAGATACGAATCTTTAGCAAATTCAGGTTGTTATGAAGCTAGACAAGA

[0401] TTGGATTCATTACGTTGGTCCAGCTGAAGAATTTGGTTCTTGTGATCCAACTAACGGTAACTTCACAGC

[0402] ATTGGTTTTACCATTGACTAAACCAGAAAGATTGCATTTGGTTGCTTACATCATCGAGTGTGAGTTTATT

[0403] AGAGTTTTGTACCCATACGCATTTTTGCATGATAATGTTGTTGAAGCAGTTATGCCAGATTCTTCAACAA

[0404] ACAACGGTGACGATTTCCATTTGGGTGAAGCTGAAAAGAGACAAAGAAACGTTAGAATGGGTAGAAA

[0405] GCAAATCCAAGCAAAGATGATGTACCAATTGGCTAGAACTGATAAGAGATGTGCAGAAAGAGTTAAGA

[0406] GAGTTTGGAAGACAATGTTGTCTACTACATTGAAGCATAAGTCAGATTCTTTCGCATCATTGGAAGAATA

[0407] TTTGAACTACAGAATCATCGATACTGGTGGTCCTTGGGTTGAATCTGTTATGTTGTTTGGTATGGGTATG

[0408] ACTTTAACAGAAGAAGAAGATGCTCAATTGGCAGAAGTTGTTAGACCATGTTATGCTTCTTTAGCTTTG

[0409] GCAAACGATTACTTCTCATTCGATAGAGAATGGGAAGAAGCTCAAAATGGTGGTCCACCACCAACAAA

[0410] TGCAGTTTGGTTGTATATGAGATGGAATGGTATTCCAATGCCAGCTGCTAAGAAATTGGTTAGAGAAGC

[0411] ATCTAACAGATACGAAGCTAGATTTTTAGAATTGTGTGATTCTTTTAGAAGAAACAACCCATTGTACTCA

[0412] GAAAAATTGGATAAATATTTGAGAGGTTTGGCTTACCAAATTTCTGGTAATGTTGTTTGGTCATTGACTT

[0413] GTCCAAGATATCATCCAGAGTTTAGATACGATCCAAATGCTGGTATGGAAGATTTGTTAACTGCTCAAGC

[0414] TAGAGGTGACGGTGGTGCTGTTTCTGGTGGTGAAGCTGATTACACAGCAGAACATAGACAATCAATCA

[0415] TTTCTTTAGAATCACAACATACTGCTTCTTCAACAAGATATTCAGCATCTGATTGGCAATCTTCAAGATC

[0416] TTCATCTTTTTCTGAAATCTCAGTTGATGGTGAAGATGGTGAAACTCATGCAGTTAAATTGCCAGCTGA

[0417] ACAAGGTTTAGATACAAAACATGTTGCTGCACCATTTGATTATGTTGCTTCTTTGCCATCAAAGGGTGTT

[0418] AGAACTACATTGATCGATGCATTGAATTTGTGGTGTGATTTGCCAGATACTACATTGGCTGGTATTAAAG

[0419] AAGTTGTTGATAAATTGCATACAGCATCTTTAATGTTCGATGATATCGAAGATGGTTCAGAATTGAGAAG

[0420] AGGTAATCCAGCTGCACATGCAGTTTACGGTGTTCCACAAACTATTAATGCTGCATCTTTTGCTATTGTT

[0421] GATGCAGTTTCAAAAGCTCAAGATATTCCAGTTACAGGTGCTGTTGATATTGTTTTAGAACAATTGAGA

[0422] GATTTGCATATCGGTCAATCTTATGATATCCATTGGACTAGACATTCATCTTGTCCATCAGAAACAGAATA

[0423] CTTAGAAATGGTTGCTAAGAAAACTGGTGGTTTGTTTAAATTAATTTCTAGATTGATGACTACAGGTTTA

[0424] CCAGATATCACTAAATCAACAATCGATGATTTGGTTACACAATTGGGTATCTATTTCCAAATCAGAGATG

[0425] ATTTCAAGAATTTGAACTCTGATGAATACGCTTCACAAAAAGGTTTCTGTGAAGATTTGGATGAGGGTA

[0426] AATTTTCTTTCCCATTGGTTCATTATTTGACTAAAGGTCAAGAATCTCCACCTTTTATGTTGAGAGAAAT

[0427] CATGCAACAAAGAAGAGAATCTAAGGGTTTGAACGTTCCATCAAAGATGTTGGCTTTGCAACAATTGA

[0428] AGAAATCTGGTTCTTTAGAATACACTCATAGAACATTGAAGAGATTAGAAGTTCAAATTAATCAAATCAT

[0429] TGGTAGATTGGAAAGAATCACTGGTAAAGATAACTGGGTTTTGAGATTGTGTATGGGTGAATTAACAGT

[0430] TTGA

[0431] SEQ ID NO. 15

[0432] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTA

[0433] LVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQ

[0434] AKMMYQLARTDKRCAERVKRVWKTMLSTTLKHKSDSFASLEEYLNYRIIDTGGYFVESVMLFGMGMTLT

[0435] EEEDAQLAEVVRPCYASLALANDYFSFDREWEEAQNGGPPPTNAVWLYMRWNGIPMPAAKKLVREASNR

[0436] YEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARGD

[0437] GGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDTK

[0438] HVAAPFDYVASLPSKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMFDDIEDGSELRRGNPAAHA

[0439] VYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKTG

[0440] GLFKLISRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDFKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTKG

[0441] QESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[0442] >SEQ ID NO.16

[0443] ATGTGTACTATGGATGATCATACATCTGAATTGTTGGATATCTCACAATTCGATACTCAAGGTTTCTGTCC

[0444] AGGTTATCCATTGAGAAGACATAGATACGAATCTTTAGCAAATTCAGGTTGTTATGAAGCTAGACAAGA

[0445] TTGGATTCATTACGTTGGTCCAGCTGAAGAATTTGGTTCTTGTGATCCAACTAACGGTAACTTCACAGC

[0446] ATTGGTTTTACCATTGACTAAACCAGAAAGATTGCATTTGGTTGCTTACATCATCGAGTGTGAGTTTATT

[0447] AGAGTTTTGTACCCATACGCATTTTTGCATGATAATGTTGTTGAAGCAGTTATGCCAGATTCTTCAACAA

[0448] ACAACGGTGACGATTTCCATTTGGGTGAAGCTGAAAAGAGACAAAGAAACGTTAGAATGGGTAGAA

[0449] GCAAATCCAAGCAAAGATGATGTACCAATTGGCTAGAACTGATAAGAGATGTGCAGAAAGTTAAGA

[0450]

[0451] >SEQ ID NO.17

[0452] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTALVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQAKMMYQLARTDKRCAERVKRVWKTMLSTTLKHKSDSFASLEEYLNYRIIDTGGYWVESVMLFGMGMTLTEEEDAQLAEVVRPCYAALALANDYFSFDREWEEAQNGGPPPTNAVWLYMRWNGIPMPAAKKLVREASNRYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARGDGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDTKHVAAPFDYVASLPSKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMFDDIEDGSELRRGNPAAHAVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKTGGLFKLISRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDFKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTKGQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[0453] >SEQ ID NO.18

[0454]

[0455] >SEQ ID NO.19

[0456] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTALVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQAKMMYQLARTDKRCAERVKRVWKTMLSTTLKHKSDSFASLEEYLNYRIIDTGGYWVESVMLFGMGMTLTEEEDAQLAEVVRPCYASLALANDYFSFDREWAEAQNGGPPPTNAVWLYMRWNGIPMPAAKKLVREASNRYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARGDGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDTKHVAAPFDYVASLPSKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMFDDIEDGSELRRGNPAAHAVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKTGGLFKLISRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDFKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTKGQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[0457] >SEQ ID NO.20

[0458]

[0459] >SEQ ID NO.21

[0460] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTALVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQAKMMYQLARTDKRCAERVKRVWKTMLSTTLKHKSDSFASLEEYLNYRIIDTGGYWVESVMLFGMGMTLTEEEDAQLAEVVRPCYASLALANDYFSFDREWEEFQNGGPPPTNAVWLYMRWNGIPMPAAKKLVREASNRYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARGDGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDTKHVAAPFDYVASLPSKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMFDDIEDGSELRRGNPAAHAVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKTGGLFKLISRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDFKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTKGQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[0461] >SEQ ID NO.22

[0462]

[0463] >SEQ ID NO.23

[0464] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTALVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQAKMMYQLARTDKRCAERVKRVWKTMLSTTLKHKSDSFASLEEYLNYRIIDTGGYWVESVMLFGMGMTLTEEEDAQLAEVVRPCYASLALANDYFSFDREWEEAQNGGPPLTNAVWLYMRWNGIPMPAAKKLVREASNRYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARGDGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDTKHVAAPFDYVASLPSKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMFDDIEDGSELRRGNPAAHAVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKTGGLFKLISRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDFKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTKGQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[0465] >SEQ ID NO.24

[0466]

[0467] >SEQ ID NO.25

[0468] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTALVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQAKMMYQLARTDKRCAERVKRVWKTMLSTTLKHKSDSFASLEEYLNYRIIDTGGYWVESVMLFGMGMTLTEEEDAQLAEVVRPCYASLALANDYFSFDREWEEAQNGGPPPTNAVWLYMRWNGIPMPAAKKLVREASNRYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARGDGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDTKHVAAPFDYVASLPSKGVRDTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMFDDIEDGSELRRGNPAAHAVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKTGGLFKLISRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDFKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTKGQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[0469] >SEQ ID NO.26

[0470] ATGTGTACTATGGATGATCATACATCTGAATTGTTGGATATCTCACAATTCGATACTCAAGGTTTCTGTCCAGGTTATCCATTGAGAAGACATAGATACGAATCTTTAGCAAATTCAGGTTGTTATGAAGCTAGACAAGATTGGATTCATTACGTTGGTCCAGCTGAAGAATTT GGTTCTTGTGATCCAACTAACGGTAACTTCACAGCATTGGTTTTACCATTGACTAAACCAGAAAGATTGCATTTGGTTGCTTACATCATCGAGTGTGAGTTTATTAGAGTTTTGTACCCATACGCATTTTTGCATGATAATGTTGTTGAAGCAGTTATGCCAGATTCTTCAACAA

[0471] ACAACGTGACGATTTCCATTTGGGTGAAGCTGAAAAGAGACAAAGAAACGTTAGAATGGGTAGAAA

[0472] GCAAATCCAAGCAAAGATGATGTACCAATTGGCTAGAACTGATAAGAGATGTGCAGAAAGAGTTAAGA

[0473] GAGTTTGGAAGACAATGTTGTCTACTACATTGAAGCATAAGTCAGATTCTTTCGCATCATTGGAAGAATA

[0474] TTTGAACTACAGAATCATCGATACTGGTGGTTACTGGGTTGAATCTGTTATGTTGTTTGGTATGGGTATG

[0475] ACTTTAACAGAAGAAGAAGATGCTCAATTGGCAGAAGTTGTTAGACCATGTTATGCTTCTTTAGCTTTG

[0476] GCAAACGATTACTTCTCATTCGATAGAGAATGGGAAGAAGCTCAAAATGGTGGTCCACCACCAACAAA

[0477] TGCAGTTTGGTTGTATATGAGATGGAATGGTATTCCAATGCCAGCTGCTAAGAAATTGGTTAGAGAAGC

[0478] ATCTAACAGATACGAAGCTAGATTTTTAGAATTGTGTGATTCTTTTAGAAGAAACAACCCATTGTACTCA

[0479] GAAAAATTGGATAAATATTTGAGAGGTTTGGCTTACCAAATTTCTGGTAATGTTGTTTGGTCATTGACTT

[0480] GTCCAAGATATCATCCAGAGTTTAGATACGATCCAAATGCTGGTATGGAAGATTTGTTAACTGCTCAAGC

[0481] TAGAGGTGACGGTGGTGCTGTTTCTGGTGGTGAAGCTGATTACACAGCAGAACATAGACAATCAATCA

[0482] TTTCTTTAGAATCACAACATACTGCTTCTTCAACAAGATATTCAGCATCTGATTGGCAATCTTCAAGATC

[0483] TTCATCTTTTTCTGAAATCTCAGTTGATGGTGAAGATGGTGAAACTCATGCAGTTAAATTGCCAGCTGA

[0484] ACAAGGTTTAGATACAAAACATGTTGCTGCACCATTTGATTATGTTGCTTCTTTGCCATCAAAGGGTGTT

[0485] AGAGATACATTGATCGATGCATTGAATTTGTGGTGTGATTTGCCAGATACTACATTGGCTGGTATTAAAG

[0486] AAGTTGTTGATAAATTGCATACAGCATCTTTAATGTTCGATGATATCGAAGATGGTTCAGAATTGAGAAG

[0487] AGGTAATCCAGCTGCACATGCAGTTTACGGTGTTCCACAAACTATTAATGCTGCATCTTTTGCTATTGTT

[0488] GATGCAGTTTCAAAAGCTCAAGATATTCCAGTTACAGGTGCTGTTGATATTGTTTTAGAACAATTGAGA

[0489] GATTTGCATATCGGTCAATCTTATGATATCCATTGGACTAGACATTCATCTTGTCCATCAGAAACAGAATA

[0490] CTTAGAAATGGTTGCTAAGAAAACTGGTGGTTTGTTTAAATTAATTTCTAGATTGATGACTACAGGTTTA

[0491] CCAGATATCACTAAATCAACAATCGATGATTTGGTTACACAATTGGGTATCTATTTCCAAATCAGAGATG

[0492] ATTTCAAGAATTTGAACTCTGATGAATACGCTTCACAAAAAGGTTTCTGTGAAGATTTGGATGAGGGTA

[0493] AATTTTCTTTCCCATTGGTTCATTATTTGACTAAAGGTCAAGAATCTCCACCTTTTATGTTGAGAGAAAT

[0494] CATGCAACAAAGAAGAGAATCTAAGGGTTTGAACGTTCCATCAAAGATGTTGGCTTTGCAACAATTGA

[0495] AGAAATCTGGTTCTTTAGAATACACTCATAGAACATTGAAGAGATTAGAAGTTCAAATTAATCAAATCAT

[0496] TGGTAGATTGGAAAGAATCACTGGTAAAGATAACTGGGTTTTGAGATTGTGTATGGGTGAATTAACAGT

[0497] TTGA

[0498] SEQ ID NO.27

[0499] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTA

[0500] LVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQ

[0501] AKMMYQLARTDKRCAERVKRVWKTMLSTTLKHKSDSFASLEEYLNYRIIDTGGYWVESVMLFGMGMTL

[0502] TEEEDAQLAEVVRPCYASLALANDYFSFDREWEEAQNGGPPPTNAVWLYMRWNGIPMPAAKKLVREASN

[0503] RYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARG

[0504] DGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDT

[0505] KHVAAPFDYVASLPSKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMLDDIEDGSELRRGNPAAH

[0506] AVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKT

[0507] GGLFKLISRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDFKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTK

[0508] GQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[0509] SEQ ID NO.28

[0510] ATGTGTACTATGGATGATCATACATCTGAATTGTTGGATATCTCACAATTCGATACTCAAGGTTTCTGTCC

[0511] AGGTTATCCATTGAGAAGACATAGATACGAATCTTTAGCAAATTCAGGTTGTTATGAAGCTAGACAAGA

[0512] TTGGATTCATTACGTTGGTCCAGCTGAAGAATTTGGTTCTTGTGATCCAACTAACGGTAACTTCACAGC

[0513] ATTGGTTTTACCATTGACTAAACCAGAAAGATTGCATTTGGTTGCTTACATCATCATCGAGGTGTGAGTTTATT

[0514] AGAGTTTGTACCCATACGCATTTTTGCATGATAATGTGTGTTGAAGCAGTTATGCCAGATTCTTCAACAA

[0515] ACAACGTGACGATTTCCATTTGGGTGAAGCTGAAAAGAGACAAAGAAACGTTAGAATGGGTAGAAA

[0516] GCAAATCCAAGCAAAGATGATGTACCAATTGGCTAGAACTGATAAGAGATGTGCAGAAAGAGTTAAGA

[0517] GAGTTTGGAAGACAATGTTGTCTACTACATTGAAGCATAAGTCAGATTCTTTCGCATCATTGGAAGAATA

[0518] TTTGAACTACAGAATCATCGATACTGGTGGTTACTGGGTTGAATCTGTTATGTTGTTTGGTATGGGTATG

[0519] ACTTTAACAGAAGAAGAAGATGCTCAATTGGCAGAAGTTGTTAGACCATGTTATGCTTCTTTAGCTTTG

[0520] GCAAACGATTACTTCTCATTCGATAGAGAATGGGAAGAAGCTCAAAATGGTGGTCCACCACCAACAAA

[0521] TGCAGTTTGGTTGTATATGAGATGGAATGGTATTCCAATGCCAGCTGCTAAGAAATTGGTTAGAGAAGC

[0522] ATCTAACAGATACGAAGCTAGATTTTTAGAATTGTGTGATTCTTTTAGAAGAAACAACCCATTGTACTCA

[0523] GAAAAATTGGATAAATATTTGAGAGGTTTGGCTTACCAAATTTCTGGTAATGTTGTTTGGTCATTGACTT

[0524] GTCCAAGATATCATCCAGAGTTTAGATACGATCCAAATGCTGGTATGGAAGATTTGTTAACTGCTCAAGC

[0525] TAGAGGTGACGGTGGTGCTGTTTCTGGTGGTGAAGCTGATTACACAGCAGAACATAGACAATCAATCA

[0526] TTTCTTTAGAATCACAACATACTGCTTCTTCAACAAGATATTCAGCATCTGATTGGCAATCTTCAAGATC

[0527] TTCATCTTTTTCTGAAATCTCAGTTGATGGTGAAGATGGTGAAACTCATGCAGTTAAATTGCCAGCTGA

[0528] ACAAGGTTTAGATACAAAACATGTTGCTGCACCATTTGATTATGTTGCTTCTTTGCCATCAAAGGGTGTT

[0529] AGAACTACATTGATCGATGCATTGAATTTGTGGTGTGATTTGCCAGATACTACATTGGCTGGTATTAAAG

[0530] AAGTTGTTGATAAATTGCATACAGCATCTTTAATGTTGGATGATATCGAAGATGGTTCAGAATTGAGAAG

[0531] AGGTAATCCAGCTGCACATGCAGTTTACGGTGTTCCACAAACTATTAATGCTGCATCTTTTGCTATTGTT

[0532] GATGCAGTTTCAAAAGCTCAAGATATTCCAGTTACAGGTGCTGTTGATATTGTTTTAGAACAATTGAGA

[0533] GATTTGCATATCGGTCAATCTTATGATATCCATTGGACTAGACATTCATCTTGTCCATCAGAAACAGAATA

[0534] CTTAGAAATGGTTGCTAAGAAAACTGGTGGTTTGTTTAAATTAATTTCTAGATTGATGACTACAGGTTTA

[0535] CCAGATATCACTAAATCAACAATCGATGATTTGGTTACACAATTGGGTATCTATTTCCAAATCAGAGATG

[0536] ATTTCAAGAATTTGAACTCTGATGAATACGCTTCACAAAAAGGTTTCTGTGAAGATTTGGATGAGGGTA

[0537] AATTTTCTTTCCCATTGGTTCATTATTTGACTAAAGGTCAAGAATCTCCACCTTTTATGTTGAGAGAAAT

[0538] CATGCAACAAAGAAGAGAATCTAAGGGTTTGAACGTTCCATCAAAGATGTTGGCTTTGCAACAATTGA

[0539] AGAAATCTGGTTCTTTAGAATACACTCATAGAACATTGAAGAGATTAGAAGTTCAAATTAATCAAATCAT

[0540] TGGTAGATTGGAAAGAATCACTGGTAAAGATAACTGGGTTTTGAGATTGTGTATGGGTGAATTAACAGT

[0541] TTGA

[0542] >SEQ ID NO.29

[0543] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTA

[0544] LVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQ

[0545] AKMMYQLARTDKRCAERVKRVWKTMLSTTLKHKSDSFASLEEYLNYRIIDTGGYWVESVMLFGMGMTL

[0546] TEEEDAQLAEVVRPCYASLALANDYFSFDREWEEAQNGGPPPTNAVWLYMRWNGIPMPAAKKLVREASN

[0547] RYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARG

[0548] DGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDT

[0549] KHVAAPFDYVASLPSKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMFDDIEDGSELRRGNPAAH

[0550] AVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKT

[0551] GGLFKLLSRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDFKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTK

[0552] GQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[0553] >SEQ ID NO.30

[0554] ATGTGTACTATGGATGATCATACATCTGAATTGTTGGATATCTCACAATTCGATACTCAAGGTTTCTGTCC

[0555] AGGTTATCCATTGAGAAGACATAGATACGAATCTTTAGCAAATTCAGGTTGTTATGAAGCTAGACAAGA

[0556] TTGGATTCATTACGTTGGTCCAGCTGAAGAATTTGGTTCTTGTGATCCAACTAACGGTAACTTCACAGC

[0557] ATTGGTTTTACCATTGACTAAACCAGAAAGATTGCATTTGGTTGCTTACATCATCGAGTGTGAGTTTATT

[0558] AGAGTTTTGTACCCATACGCATTTTTGCATGATAATGTTGTTGAAGCAGTTATGCCAGATTCTTCAACAA

[0559] ACAACGGTGACGATTTCCATTTGGGTGAAGCTGAAAAGAGACAAAGAAACGTTAGAATGGGTAGAAA

[0560] GCAAATCCAAGCAAAGATGATGTACCAATTGGCTAGAACTGATAAGAGATGTGCAGAAAGAGTTAAGA

[0561] GAGTTTGGAAGACAATGTTGTCTACTACATTGAAGCATAAGTCAGATTCTTTCGCATCATTGGAAGAATA

[0562] TTTGAACTACAGAATCATCGATACTGGTGGTTACTGGGTTGAATCTGTTATGTTGTTTGGTATGGGTATG

[0563] ACTTTAACAGAAGAAGAAGATGCTCAATTGGCAGAAGTTGTTAGACCATGTTATGCTTCTTTAGCTTTG

[0564] GCAAACGATTACTTCTCATTCGATAGAGAATGGGAAGAAGCTCAAAATGGTGGTCCACCACCAACAAA

[0565] TGCAGTTTGGTTGTATATGAGATGGAATGGTATTCCAATGCCAGCTGCTAAGAAATTGGTTAGAGAAGC

[0566] ATCTAACAGATACGAAGCTAGATTTTTAGAATTGTGTGATTCTTTTAGAAGAAACAACCCATTGTACTCA

[0567] GAAAAATTGGATAAATATTTGAGAGGTTTGGCTTACCAAATTTCTGGTAATGTTGTTTGGTCATTGACTT

[0568] GTCCAAGATATCATCCAGAGTTTAGATACGATCCAAATGCTGGTATGGAAGATTTGTTAACTGCTCAAGC

[0569] TAGAGGTGACGGTGGTGCTGTTTCTGGTGGTGAAGCTGATTACACAGCAGAACATAGACAATCAATCA

[0570] TTTCTTTAGAATCACAACATACTGCTTCTTCAACAAGATATTCAGCATCTGATTGGCAATCTTCAAGATC

[0571] TTCATCTTTTTCTGAAATCTCAGTTGATGGTGAAGATGGTGAAACTCATGCAGTTAAATTGCCAGCTGA

[0572] ACAAGGTTTAGATACAAAACATGTTGCTGCACCATTTGATTATGTTGCTTCTTTGCCATCAAAGGGTGTT

[0573] AGAACTACATTGATCGATGCATTGAATTTGTGGTGTGATTTGCCAGATACTACATTGGCTGGTATTAAAG

[0574] AAGTTGTTGATAAATTGCATACAGCATCTTTAATGTTCGATGATATCGAAGATGGTTCAGAATTGAGAAG

[0575] AGGTAATCCAGCTGCACATGCAGTTTACGGTGTTCCACAAACTATTAATGCTGCATCTTTTGCTATTGTT

[0576] GATGCAGTTTCAAAAGCTCAAGATATTCCAGTTACAGGTGCTGTTGATATTGTTTTAGAACAATTGAGA

[0577] GATTTGCATATCGGTCAATCTTATGATATCCATTGGACTAGACATTCATCTTGTCCATCAGAAACAGAATA

[0578] CTTAGAAATGGTTGCTAAGAAAACTGGTGGTTTGTTTAAATTATTGTCTAGATTGATGACTACAGGTTTA

[0579] CCAGATATCACTAAATCAACAATCGATGATTTGGTTACACAATTGGGTATCTATTTCCAAATCAGAGATG

[0580] ATTTCAAGAATTTGAACTCTGATGAATACGCTTCACAAAAAGGTTTCTGTGAAGATTTGGATGAGGGTA

[0581] AATTTTCTTTCCCATTGGTTCATTATTTGACTAAAGGTCAAGAATCTCCACCTTTTATGTTGAGAGAAAT

[0582] CATGCAACAAAGAAGAGAATCTAAGGGTTTGAACGTTCCATCAAAGATGTTGGCTTTGCAACAATTGA

[0583] AGAAATCTGGTTCTTTAGAATACACTCATAGAACATTGAAGAGATTAGAAGTTCAAATTAATCAAATCAT

[0584] TGGTAGATTGGAAAGAATCACTGGTAAAGATAACTGGGTTTTGAGATTGTGTATGGGTGAATTAACAGT

[0585] TTGA

[0586] >SEQ ID NO.31

[0587] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTA

[0588] LVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQ

[0589] AKMMYQLARTDKRCAERVKRVWKTMLSTTLKHKSDSFASLEEYLNYRIIDTGGYWVESVMLFGMGMTL

[0590] TEEEDAQLAEVVRPCYASLALANDYFSFDREWEEAQNGGPPPTNAVWLYMRWNGIPMPAAKKLVREASN

[0591] RYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARG

[0592] DGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDT

[0593] KHVAAPFDYVASLPSKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMFDDIEDGSELRRGNPAAH

[0594] AVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKT

[0595] GGLFKLISRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDYKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTK

[0596] GQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[0597] >SEQ ID NO.32

[0598] ATGTGTACTATGGATGATCATACATCTGAATTGTTGGATATCTCACAATTCGATACTCAAGGTTTCTGTCC

[0599] AGGTTATCCATTGAGAAGACATAGATACGAATCTTTAGCAAATTCAGGTTGTTATGAAGCTAGACAAGA

[0600] TTGGATTCATTACGTTGGTCCAGCTGAAGAATTTGGTTCTTGTGATCCAACTAACGGTAACTTCACAGC

[0601] ATTGGTTTTACCATTGACTAAACCAGAAAGATTGCATTTGGTTGCTTACATCATCGAGTGTGAGTTTATT

[0602] AGAGTTTTGTACCCATACGCATTTTTGCATGATAATGTTGTTGAAGCAGTTATGCCAGATTCTTCAACAA

[0603] ACAACGGTGACGATTTCCATTTGGGTGAAGCTGAAAAGAGACAAAGAAACGTTAGAATGGGTAGAAA

[0604] GCAAATCCAAGCAAAGATGATGTACCAATTGGCTAGAACTGATAAGAGATGTGCAGAAAGAGTTAAGA

[0605] GAGTTTGGAAGACAATGTTGTCTACTACATTGAAGCATAAGTCAGATTCTTTCGCATCATTGGAAGAATA

[0606] TTTGAACTACAGAATCATCGATACTGGTGGTTACTGGGTTGAATCTGTTATGTTGTTTGGTATGGGTATG

[0607] ACTTTAACAGAAGAAGAAGATGCTCAATTGGCAGAAGTTGTTAGACCATGTTATGCTTCTTTAGCTTTG

[0608] GCAAACGATTACTTCTCATTCGATAGAGAATGGGAAGAAGCTCAAAATGGTGGTCCACCACCAACAAA

[0609] TGCAGTTTGGTTGTATATGAGATGGAATGGTATTCCAATGCCAGCTGCTAAGAAATTGGTTAGAGAAGC

[0610] ATCTAACAGATACGAAGCTAGATTTTTAGAATTGTGTGATTCTTTTAGAAGAAACAACCCATTGTACTCA

[0611] GAAAAATTGGATAAATATTTGAGAGGTTTGGCTTACCAAATTTCTGGTAATGTTGTTTGGTCATTGACTT

[0612] GTCCAAGATATCATCCAGAGTTTAGATACGATCCAAATGCTGGTATGGAAGATTTGTTAACTGCTCAAGC

[0613] TAGAGGTGACGGTGGTGCTGTTTCTGGTGGTGAAGCTGATTACACAGCAGAACATAGACAATCAATCA

[0614] TTTCTTAGAATCACAACATACTGCTTCTTCAACAAGATATTCAGCATCTGATTGGCAATCTTCAAGATC

[0615] TTCATCTTTTTCTGAAATCTCAGTTGATGGTGAAGATGGTGAAACTCATGCAGTTAAATTGCCAGCTGA

[0616] ACAAGGTTTAGATACAAAACATGTTGCTGCACCATTTGATTATGTTGCTTCTTTGCCATCAAAGGGTGTT

[0617] AGAACTACATTGATCGATGCATTGAATTTGTGGTGTGATTTGCCAGATACTACATTGGCTGGTATTAAAG

[0618] AAGTTGTTGATAAATTGCATACAGCATCTTTAATGTTCGATGATATCGAAGATGGTTCAGAATTGAGAAG

[0619] AGGTAATCCAGCTGCACATGCAGTTTACGGTGTTCCACAAACTATTAATGCTGCATCTTTTGCTATTGTT

[0620] GATGCAGTTTCAAAAGCTCAAGATATTCCAGTTACAGGTGCTGTTGATATTGTTTTAGAACAATTGAGA

[0621] GATTTGCATATCGGTCAATCTTATGATATCCATTGGACTAGACATTCATCTTGTCCATCAGAAACAGAATA

[0622] CTTAGAAATGGTTGCTAAGAAAACTGGTGGTTTGTTTAAATTAATTTCTAGATTGATGACTACAGGTTTA

[0623] CCAGATATCACTAAATCAACAATCGATGATTTGGTTACACAATTGGGTATCTATTTCCAAATCAGAGATG

[0624] ATTATAAATTTGAACTCTGATGAATACGCTTCACAAAAAGGTTTCTGTGAAGATTTGGATGAGGTA

[0625] AATTTTCTTTCCCATTGGTTCATTATTGACTAAAGGTCAAGAATCTCCACCTTTTATGTTGAGAGAAT

[0626] CATGCAACAAAGAAGAGAATCTAAGGGTTTGAACGTTCCATCAAAGATGTTGGCTTTGCAACAATTGA

[0627] AGAAATCTGGTTCTTTAGAATACACTCATAGAACATTGAAGATTAGAAGTTCAAATTAATCAAATCAT

[0628] TGGTAGATTGGAAAGAATCACTGGTAAAGATAACTGGGTTTTGAGATTGTGTATGGGTGAATTAACAGT

[0629] TTGA

[0630] >SEQ ID NO.33

[0631] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTA

[0632] LVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQQIQ

[0633] AKMMYQLARTDKRCAERVKRVWKTMLSTTLKDKSDSFASLEEYLNYRIIDTGGYWVESVMLFGMGMTL

[0634] TEEEDAQLAEVVRPCYASLALANDYFSFDREWEEFQNGGPPPTNAVWLYMRWNGIPMPAAKKLVREASNRYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARGDGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDTKHVAAPFDYVASLPSKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMFDDIEDGSELRRGNPAAHAVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKTGGLFKLISRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDFKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTKGQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[0635] >SEQ ID NO.34

[0636]

[0637] >SEQ ID NO.35

[0638] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTALVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQAKMMYQLARTDKRCAERVKRVWKTMLSTTLKHKSDSFASLEEYLNYRIIDTGAYWVESVMLFGMGMTLTEEEDAQLAEVVRPCYASLALANDYFSFDREWEEFQNGGPPPTNAVWLYMRWNGIPMPAAKKLVREASNRYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARGDGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDTKHVAAPFDYVASLPSKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMFDDIEDGSELRRGNPAAHAVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKTGGLFKLISRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDFKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTKGQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[0639]

[0640] >SEQ ID NO.37

[0641] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTALVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQAKMMYQLARTDKRCAERVKRVWKTMLSTTLKDKSDSFASLEEYLNYRIIDTGGPWVESVMLFGMGMTLTEEEDAQLAEVVRPCYASLALANDYFSFDREWEEAQNGGPPPTNAVWLYMRWNGIPMPAAKKLVREASNRYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARGDGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDTKHVAAPFDYVASLPSKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMFDDIEDGSELRRGNPAAHAVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKTGGLFKLISRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDFKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTKGQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[0642] >SEQ ID NO.38

[0643] ATGTGTACTATGGATGATCATACATCTGAATTGTTGGATATCTCACAATTCGATACTCAAGGTTTCTGTCCAGGTTATCCATTGAGAAGACATAGATACGAATCTTTAGCAAATTCAGGTTGTTATGAAGCTAGACAAGATTGGATTCATTACGTTGGTCCAGCTGAAGAATTTGGTTTCTTGTGATCCAACTAACGGTAACTTCACAGCATTGGTTTTACCATTG ACTAAACCAGAAAGATTGCATTTGGTTGCTTACATCATCGAGTGTGAGTTTATTAGAGTTTTGTACCCATACGCATTTTTGCATGATAATGTTGTTGAAGCAGTTATGCCAGATTCTTCAACAAACAACGGTGACGATTTCCATTTGGGTGAAGCTGAAAAGAGACAAAGAAACGTTAGAATGGGTAGAAAGCAAATCCAAGCAAAGATGATGTACCAATTGGCT AGAACTGATAAGAGATGTGCAGAAAGAGTTAAGAGAGTTTGGAAGACAATGTTGTCTACTACATTGAAGGATAAGTCAGATTCTTTCGCATCATTGGAAGAATATTTGAACTACAGAATCATCGATACTGGTGGTCCTTGGGTTGAATCTGTTATGTTGTTTGGTATGGGTATGACTTTAACAGAAGAAGAAGATGCTCAATTGGCAGAAGTTGTTAGACCATGTTATGCTTCTTTAGCTTTGGCAAACGATTACTTCTCATTCGATAGAGAATGGGAAGAAGCTCAAAATGGTGGTCCACCACCAACAAATGCAGTTTGGTTGTATATGAGATGGAATGGTATTCCAATGCCAGCTGCTAAGAAATTGGTTAGAGAAGCATCTAACAGATACGAAGCTAGATTTTTAGAATTGTGTGATTCTTTTAGAAGAAACAACCCATTGTACTCA

[0644] GAAAAATTGGATAAATATTTGAGAGGTTTGGCTTACCAAAATTTCTGGTAATGTTGTTTGGTCATTGACTT

[0645] GTCCAAGATATCATCCAGAGTTTAGATACGATCCAAATGCTGGTATGGAAGATTTGTTAACTGCTCAAGC

[0646] TAGAGGTGACGGTGGTGCTGTTTCTGGTGGTGAAGCTGATTACACAGCAGAACATAGACAATCAATCA

[0647] TTTCTTTAGAATCACAACATACTGCTTCTTCAACAAGATATTCAGCATCTGATTGGCAATCTTCAAGATC

[0648] TTCATCTTTTTCTGAAATCTCAGTTGATGGTGAAGATGGTGAAACTCATGCAGTTAAATTGCCAGCTGA

[0649] ACAAGGTTTAGATACAAAACATGTTGCTGCACCATTTGATTATGTTGCTTCTTTGCCATCAAAGGGTGTT

[0650] AGAACTACATTGATCGATGCATTGAATTTGTGGTGTGATTTGCCAGATACTACATTGGCTGGTATTAAAG

[0651] AAGTTGTTGATAAATTGCATACAGCATCTTTAATGTTCGATGATATCGAAGATGGTTCAGAATTGAGAAG

[0652] AGGTAATCCAGCTGCACATGCAGTTTACGGTGTTCCACAAACTATTAATGCTGCATCTTTTGCTATTGTT

[0653] GATGCAGTTTCAAAAGCTCAAGATATTCCAGTTACAGGTGCTGTTGATATTGTTTTAGAACAATTGAGA

[0654] GATTTGCATATCGGTCAATCTTATGATATCCATTGGACTAGACATTCATCTTGTCCATCAGAAACAGAATA

[0655] CTTAGAAATGGTTGCTAAGAAAACTGGTGGTTTGTTTAAATTAATTTCTAGATTGATGACTACAGGTTTA

[0656] CCAGATATCACTAAATCAACAATCGATGATTTGGTTACACAATTGGGTATCTATTTCCAAATCAGAGATG

[0657] ATTTCAAGAATTTGAACTCTGATGAATACGCTTCACAAAAAGGTTTCTGTGAAGATTTGGATGAGGGTA

[0658] AATTTTCTTTCCCATTGGTTCATTATTTGACTAAAGGTCAAGAATCTCCACCTTTTATGTTGAGAGAAAT

[0659] CATGCAACAAAGAAGAGAATCTAAGGGTTTGAACGTTCCATCAAAGATGTTGGCTTTGCAACAATTGA

[0660] AGAAATCTGGTTCTTTAGAATACACTCATAGAACATTGAAGAGATTAGAAGTTCAAATTAATCAAATCAT

[0661] TGGTAGATTGGAAAGAATCACTGGTAAAGATAACTGGGTTTTGAGATTGTGTATGGGTGAATTAACAGT

[0662] TTGA

[0663] SEQ ID NO.39

[0664] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTA

[0665] LVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQ

[0666] AKMMYQLARTDKRCAERVKRVWKTMLSTTLKDKSDSFASLEEYLNYRIIDTGAYWVESVMLFGMGMTL

[0667] TEEEDAQLAEVVRPCYASLALANDYFSFDREWEEAQNGGPPPTNAVWLYMRWNGIPMPAAKKLVREASN

[0668] RYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARG

[0669] DGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDT

[0670] KHVAAPFDYVASLPSKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMFDDIEDGSELRRGNPAAH

[0671] AVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKT

[0672] GGLFKLISRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDFKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTK

[0673] GQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[0674] >SEQ ID NO.40

[0675] ATGTGTACTATGGATGATCATACATCTGAATTGTTGGATATCTCACAATTCGATACTCAAGGTTTCTGTCC

[0676] AGGTTATCCATTGAGAAGACATAGATACGAATCTTTAGCAAATTCAGGTTGTTATGAAGCTAGACAAGA

[0677] TTGGATTCATTACGTTGGTCCAGCTGAAGAATTTGGTTCTTGTGATCCAACTAACGGTAACTTCACAGC

[0678] ATTGGTTTTACCATTGACTAAACCAGAAAGATTGCATTTGGTTGCTTACATCATCGAGTGTGAGTTTATT

[0679] AGAGTTTTGTACCCATACGCATTTTTGCATGATAATGTTGTTGAAGCAGTTATGCCAGATTCTTCAACAA

[0680] ACAACGGTGACGATTTCCATTTGGGTGAAGCTGAAAAGAGACAAAGAAACGTTAGAATGGGTAGAAA

[0681] GCAAATCCAAGCAAAGATGATGTACCAATTGGCTAGAACTGATAAGAGATGTGCAGAAAGAGTTAAGA

[0682] GAGTTTGGAAGACAATGTTGTCTACTACATTGAAGGATAAGTCAGATTCTTTCGCATCATTGGAAGAATA

[0683] TTTGAACTACAGAATCATCGATACTGGTGCTTACTGGGTTGAATCTGTTATGTTGTTTGGTATGGGTATG

[0684] ACTTTAACAGAAGAAGAAGATGCTCAATTGGCAGAAGTTGTTAGACCATGTTATGCTTCTTTAGCTTTG

[0685] GCAAACGATTACTTCTCATTCGATAGAGAATGGGAAGAAGCTCAAAATGGTGGTCCACCACCAACAAA

[0686] TGCAGTTTGGTTGTATATGAGATGGAATGGTATTCCAATGCCAGCTGCTAAGAAATTGGTTAGAGAAGC

[0687] ATCTAACAGATACGAAGCTAGATTTTTAGAATTGTGTGATTCTTTTAGAAGAAACAACCCATTGTACTCA

[0688] GAAAAATTGGATAAATATTTGAGAGGTTTGGCTTACCAAATTTCTGGTAATGTTGTTTGGTCATTGACTT

[0689] GTCCAAGATATCATCCAGAGTTTAGATACGATCCAAATGCTGGTATGGAAGATTTGTTAACTGCTCAAGC

[0690] TAGAGGTGACGGTGGTGCTGTTTCTGGTGGTGAAGCTGATTACACAGCAGAACATAGACAATCAATCA

[0691] TTTCTTTAGAATCACAACATACTGCTTCTTCAACAAGATATTCAGCATCTGATTGGCAATCTTCAAGATC

[0692] TTCATCTTTTTCTGAAATCTCAGTTGATGGTGAAGATGGTGAAACTCATGCAGTTAAATTGCCAGCTGA

[0693] ACAAGGTTTAGATACAAAACATGTTGCTGCACCATTTGATTATGTTGCTTCTTTGCCATCAAAGGGTGTT

[0694] AGAACTACATTGATCGATGCATTGAATTTGTGGTGTGATTTGCCAGATACTACATTGGCTGGTATTAAAG

[0695] AAGTTGTTGATAAATTGCATACAGCATCTTTAATGTTCGATGATATCGAAGATGGTTCAGAATTGAGAAG

[0696] AGGTAATCCAGCTGCACATGCAGTTTACGGTGTTCCACAAACTATTAATGCTGCATCTTTTGCTATTGTT

[0697] GATGCAGTTTCAAAAGCTCAAGATATTCCAGTTACAGGTGCTGTTGATATTGTTTTAGAACAATTGAGA

[0698] GATTTGCATATCGGTCAATCTTATGATATCCATTGGACTAGACATTCATCTTGTCCATCAGAAACAGAATA

[0699] CTTAGAAATGGTTGCTAAGAAAACTGGTGGTTTGTTTAAATTAATTTCTAGATTGATGACTACAGGTTTA

[0700] CCAGATATCACTAAATCAACAATCGATGATTTGGTTACACAATTGGGTATCTATTTCCAAATCAGAGATG

[0701] ATTTCAAGAATTTGAACTCTGATGAATACGCTTCACAAAAAGGTTTCTGTGAAGATTTGGATGAGGGTA

[0702] AATTTTCTTTCCCATTGGTTCATTATTTGACTAAAGGTCAAGAATCTCCACCTTTTATGTTGAGAGAAAT

[0703] CATGCAACAAAGAAGAGAATCTAAGGGTTTGAACGTTCCATCAAAGATGTTGGCTTTGCAACAATTGA

[0704] AGAAATCTGGTTCTTTAGAATACACTCATAGAACATTGAAGAGATTAGAAGTTCAAATTAATCAAATCAT

[0705] TGGTAGATTGGAAAGAATCACTGGTAAAGATAACTGGGTTTTGAGATTGTGTATGGGTGAATTAACAGT

[0706] TTGA

[0707] SEQ ID NO.41

[0708] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTA

[0709] LVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQ

[0710] AKMMYQLARTDKRCAERVKRVWKTMLSTTLKHKSDSFASLEEYLNYRIIDTGAPWVESVMLFGMGMTL

[0711] TEEEDAQLAEVVRPCYASLALANDYFSFDREWEEAQNGGPPPTNAVWLYMRWNGIPMPAAKKLVREASN

[0712] RYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARG

[0713] DGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDT

[0714] KHVAAPFDYVASLPSKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMFDDIEDGSELRRGNPAAH

[0715] AVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKT

[0716] GGLFKLISRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDFKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTK

[0717] GQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[0718] >SEQ ID NO.42

[0719] ATGTGTACTATGGATGATCATACATCTGAATTGTTGGATATCTCACAATTCGATACTCAAGGTTTCTGTCC

[0720] AGGTTATCCATTGAGAAGACATAGATACGAATCTTTAGCAAATTCAGGTTGTTATGAAGCTAGACAAGA

[0721] TTGGATTCATTACGTTGGTCCAGCTGAAGAATTTGGTTCTTGTGATCCAACTAACGGTAACTTCACAGC

[0722] ATTGGTTTTACCATTGACTAAACCAGAAAGATTGCATTTGGTTGCTTACATCATCATCGAGGTGTGAGTTTATT

[0723] AGAGTTTGTACCCATACGCATTTTTGCATGATAATGTGTGTTGAAGCAGTTATGCCAGATTCTTCAACAA

[0724] ACAACGTGACGATTTCCATTTGGGTGAAGCTGAAAAGAGACAAAGAAACGTTAGAATGGGTAGAAA

[0725] GCAAATCCAAGCAAAGATGATGTACCAATTGGCTAGAACTGATAAGAGATGTGCAGAAAGAGTTAAGA

[0726] GAGTTTGGAAGACAATGTTGTCTACTACATTGAAGCATAAGTCAGATTCTTTCGCATCATTGGAAGAATA

[0727] TTTGAACTACAGAATCATCGATACTGGTGCTCCTTGGGTTGAATCTGTTATGTTGTTTGGTATGGGTATG

[0728] ACTTTAACAGAAGAAGAAGATGCTCAATTGGCAGAAGTTGTTAGACCATGTTATGCTTCTTTAGCTTTG

[0729] GCAAACGATTACTTCTCATTCGATAGAGAATGGGAAGAAGCTCAAAATGGTGGTCCACCACCAACAAA

[0730] TGCAGTTTGGTTGTATATGAGATGGAATGGTATTCCAATGCCAGCTGCTAAGAAATTGGTTAGAGAAGC

[0731] ATCTAACAGATACGAAGCTAGATTTTTAGAATTGTGTGATTCTTTTAGAAGAAACAACCCATTGTACTCA

[0732] GAAAAATTGGATAAATATTTGAGAGGTTTGGCTTACCAAATTTCTGGTAATGTTGTTTGGTCATTGACTT

[0733] GTCCAAGATATCATCCAGAGTTTAGATACGATCCAAATGCTGGTATGGAAGATTTGTTAACTGCTCAAGC

[0734] TAGAGGTGACGGTGGTGCTGTTTCTGGTGGTGAAGCTGATTACACAGCAGAACATAGACAATCAATCA

[0735] TTTCTTTAGAATCACAACATACTGCTTCTTCAACAAGATATTCAGCATCTGATTGGCAATCTTCAAGATC

[0736] TTCATCTTTTTCTGAAATCTCAGTTGATGGTGAAGATGGTGAAACTCATGCAGTTAAATTGCCAGCTGA

[0737] ACAAGGTTTAGATACAAAACATGTTGCTGCACCATTTGATTATGTTGCTTCTTTGCCATCAAAGGGTGTT

[0738] AGAACTACATTGATCGATGCATTGAATTTGTGGTGTGATTTGCCAGATACTACATTGGCTGGTATTAAAG

[0739] AAGTTGTTGATAAATTGCATACAGCATCTTTAATGTTCGATGATATCGAAGATGGTTCAGAATTGAGAAG

[0740] AGGTAATCCAGCTGCACATGCAGTTTACGGTGTTCCACAAACTATTAATGCTGCATCTTTTGCTATTGTT

[0741] GATGCAGTTTCAAAAGCTCAAGATATTCCAGTTACAGGTGCTGTTGATATTGTTTTAGAACAATTGAGA

[0742] GATTTGCATATCGGTCAATCTTATGATATCCATTGGACTAGACATTCATCTTGTCCATCAGAAACAGAATA

[0743] CTTAGAAATGGTTGCTAAGAAAACTGGTGGTTTGTTTAAATTAATTTCTAGATTGATGACTACAGGTTTA

[0744] CCAGATATCACTAAATCAACAATCGATGATTTGGTTACACAATTGGGTATCTATTTCCAAATCAGAGATG

[0745] ATTTCAAGAATTTGAACTCTGATGAATACGCTTCACAAAAAGGTTTCTGTGAAGATTTGGATGAGGGTA

[0746] AATTTTCTTTCCCATTGGTTCATTATTTGACTAAAGGTCAAGAATCTCCACCTTTTATGTTGAGAGAAAT

[0747] CATGCAACAAAGAAGAGAATCTAAGGGTTTGAACGTTCCATCAAAGATGTTGGCTTTGCAACAATTGA

[0748] AGAAATCTGGTTCTTTAGAATACACTCATAGAACATTGAAGAGATTAGAAGTTCAAATTAATCAAATCAT

[0749] TGGTAGATTGGAAAGAATCACTGGTAAAGATAACTGGGTTTTGAGATTGTGTATGGGTGAATTAACAGT

[0750] TTGA

[0751] >SEQ ID NO.43

[0752] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTA

[0753] LVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQ

[0754] AKMMYQLARTDKRCAERVKRVWKTMLSTTLKHKSDSFASLEEYLNYRIIDTGGYWVESVMLFGMGMTL

[0755] TEEEDAQLAEVVRPCYASLALANDYFSFDREWEEAQNGGPPPTNAVWLYMRWNGIPMPAAKKLVREASN

[0756] RYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARG

[0757] DGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDT

[0758] KHVAAPFDYVASLPSKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMLDDIEDGSELRRGNPAAH

[0759] AVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKT

[0760] GGLFKLLSRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDFKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTK

[0761] GQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[0762] >SEQ ID NO.44

[0763] ATGTGTACTATGGATGATCATACATCTGAATTGTTGGATATCTCACAATTCGATACTCAAGGTTTCTGTCC

[0764] AGGTTATCCATTGAGAAGACATAGATACGAATCTTTAGCAAATTCAGGTTGTTATGAAGCTAGACAAGA

[0765] TTGGATTCATTACGTTGGTCCAGCTGAAGAATTTGGTTCTTGTGATCCAACTAACGGTAACTTCACAGC

[0766] ATTGGTTTTACCATTGACTAAACCAGAAAGATTGCATTTGGTTGCTTACATCATCGAGTGTGAGTTTATT

[0767] AGAGTTTTGTACCCATACGCATTTTTGCATGATAATGTTGTTGAAGCAGTTATGCCAGATTCTTCAACAA

[0768] ACAACGGTGACGATTTCCATTTGGGTGAAGCTGAAAAGAGACAAAGAAACGTTAGAATGGGTAGAAA

[0769] GCAAATCCAAGCAAAGATGATGTACCAATTGGCTAGAACTGATAAGAGATGTGCAGAAAGAGTTAAGA

[0770] GAGTTTGGAAGACAATGTTGTCTACTACATTGAAGCATAAGTCAGATTCTTTCGCATCATTGGAAGAATA

[0771] TTTGAACTACAGAATCATCGATACTGGTGGTTACTGGGTTGAATCTGTTATGTTGTTTGGTATGGGTATG

[0772] ACTTTAACAGAAGAAGAAGATGCTCAATTGGCAGAAGTTGTTAGACCATGTTATGCTTCTTTAGCTTTG

[0773] GCAAACGATTACTTCTCATTCGATAGAGAATGGGAAGAAGCTCAAAATGGTGGTCCACCACCAACAAA

[0774] TGCAGTTTGGTTGTATATGAGATGGAATGGTATTCCAATGCCAGCTGCTAAGAAATTGGTTAGAGAAGC

[0775] ATCTAACAGATACGAAGCTAGATTTTTAGAATTGTGTGATTCTTTTAGAAGAAACAACCCATTGTACTCA

[0776] GAAAAATTGGATAAATATTTGAGAGGTTTGGCTTACCAAATTTCTGGTAATGTTGTTTGGTCATTGACTT

[0777] GTCCAAGATATCATCCAGAGTTTAGATACGATCCAAATGCTGGTATGGAAGATTTGTTAACTGCTCAAGC

[0778] TAGAGGTGACGGTGGTGCTGTTTCTGGTGGTGAAGCTGATTACACAGCAGAACATAGACAATCAATCA

[0779] TTTCTTTAGAATCACAACATACTGCTTCTTCAACAAGATATTCAGCATCTGATTGGCAATCTTCAAGATC

[0780] TTCATCTTTTTCTGAAATCTCAGTTGATGGTGAAGATGGTGAAACTCATGCAGTTAAATTGCCAGCTGA

[0781] ACAAGGTTTAGATACAAAACATGTTGCTGCACCATTTGATTATGTTGCTTCTTTGCCATCAAAGGGTGTT

[0782] AGAACTACATTGATCGATGCATTGAATTTGTGGTGTGATTTGCCAGATACTACATTGGCTGGTATTAAAG

[0783] AAGTTGTTGATAAATTGCATACAGCATCTTTAATGTTGGATGATATCGAAGATGGTTCAGAATTGAGAAG

[0784] AGGTAATCCAGCTGCACATGCAGTTTACGGTGTTCCACAAACTATTAATGCTGCATCTTTTGCTATTGTT

[0785] GATGCAGTTTCAAAAGCTCAAGATATTCCAGTTACAGGTGCTGTTGATATTGTTTTAGAACAATTGAGA

[0786] GATTTGCATATCGGTCAATCTTATGATATCCATTGGACTAGACATTCATCTTGTCCATCAGAAACAGAATA

[0787] CTTAGAAATGGTTGCTAAGAAAACTGGTGGTTTGTTTAAATTATTGTCTAGATTGATGACTACAGGTTTA

[0788] CCAGATATCACTAAATCAACAATCGATGATTTGGTTACACAATTGGGTATCTATTTCCAAATCAGAGATG

[0789] ATTTCAAGAATTTGAACTCTGATGAATACGCTTCACAAAAAGGTTTCTGTGAAGATTTGGATGAGGGTA

[0790] AATTTTCTTTCCCATTGGTTCATTATTTGACTAAAGGTCAAGAATCTCCACCTTTTATGTTGAGAGAAAT

[0791] CATGCAACAAAGAAGAGAATCTAAGGGTTTGAACGTTCCATCAAAGATGTTGGCTTTGCAACAATTGA

[0792] AGAAATCTGGTTCTTTAGAATACACTCATAGAACATTGAAGAGATTAGAAGTTCAAATTAATCAAATCAT

[0793] TGGTAGATTGGAAAGAATCACTGGTAAAGATAACTGGGTTTTGAGATTGTGTATGGGTGAATTAACAGT

[0794] TTGA

[0795] >SEQ ID NO.45

[0796] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTA

[0797] LVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQ

[0798] AKMMYQLARTDKRCAERVKRVWKTMLSTTLKHKSDSFASLEEYLNYRIIDTGGYWVESVMLFGMGMTL

[0799] TEEEDAQLAEVVRPCYASLALANDYFSFDREWEEAQNGGPPPTNAVWLYMRWNGIPMPAAKKLVREASN

[0800] RYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARG

[0801] DGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDT

[0802] KHVAAPFDYVASLPSKGVRDTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMFDDIEDGSELRRGNPAAH

[0803] AVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKT

[0804] GGLFKLLSRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDFKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTK

[0805] GQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[0806] >SEQ ID NO.46

[0807] ATGTGTACTATGGATGATCATACATCTGAATTGTTGGATATCTCACAATTCGATACTCAAGGTTTCTGTCC

[0808] AGGTTATCCATTGAGAAGACATAGATACGAATCTTTAGCAAATTCAGGTTGTTATGAAGCTAGACAAGA

[0809] TTGGATTCATTACGTTGGTCCAGCTGAAGAATTTGGTTCTTGTGATCCAACTAACGGTAACTTCACAGC

[0810] ATTGGTTTTACCATTGACTAAACCAGAAAGATTGCATTTGGTTGCTTACATCATCGAGTGTGAGTTTATT

[0811] AGAGTTTTGTACCCATACGCATTTTTGCATGATAATGTTGTTGAAGCAGTTATGCCAGATTCTTCAACAA

[0812] ACAACGGTGACGATTTCCATTTGGGTGAAGCTGAAAAGAGACAAAGAAACGTTAGAATGGGTAGAAA

[0813] GCAAATCCAAGCAAAGATGATGTACCAATTGGCTAGAACTGATAAGAGATGTGCAGAAAGAGTTAAGA

[0814] GAGTTTGGAAGACAATGTTGTCTACTACATTGAAGCATAAGTCAGATTCTTTCGCATCATTGGAAGAATA

[0815] TTTGAACTACAGAATCATCGATACTGGTGGTTACTGGGTTGAATCTGTTATGTTGTTTGGTATGGGTATG

[0816] ACTTTAACAGAAGAAGAAGATGCTCAATTGGCAGAAGTTGTTAGACCATGTTATGCTTCTTTAGCTTTG

[0817] GCAAACGATTACTTCTCATTCGATAGAGAATGGGAAGAAGCTCAAAATGGTGGTCCACCACCAACAAA

[0818] TGCAGTTTGGTTGTATATGAGATGGAATGGTATTCCAATGCCAGCTGCTAAGAAATTGGTTAGAGAAGC

[0819] ATCTAACAGATACGAAGCTAGATTTTTAGAATTGTGTGATTCTTTTAGAAGAAACAACCCATTGTACTCA

[0820] GAAAAATTGGATAAATATTTGAGAGGTTTGGCTTACCAAATTTCTGGTAATGTTGTTTGGTCATTGACTT

[0821] GTCCAAGATATCATCCAGAGTTTAGATACGATCCAAATGCTGGTATGGAAGATTTGTTAACTGCTCAAGC

[0822] TAGAGGTGACGGTGGTGCTGTTTCTGGTGGTGAAGCTGATTACACAGCAGAACATAGACAATCAATCA

[0823] TTTCTTAGAATCACAACATACTGCTTCTTCAACAAGATATTCAGCATCTGATTGGCAATCTTCAAGATC

[0824] TTCATCTTTTTCTGAAATCTCAGTTGATGGTGAAGATGGTGAAACTCATGCAGTTAAATTGCCAGCTGA

[0825] ACAAGGTTTAGATACAAAACATGTTGCTGCACCATTTGATTATGTTGCTTCTTTGCCATCAAAGGGTGTT

[0826] AGAGATACATTGATCGATGCATTGAATTTGTGGTGTGATTTGCCAGATACTACATTGGCTGGTATTAAAG

[0827] AAGTTGTTGATAAATTGCATACAGCATCTTTAATGTTCGATGATATCGAAGATGGTTCAGAATTGAGAAG

[0828] AGGTAATCCAGCTGCACATGCAGTTTACGGTGTTCCACAAACTATTAATGCTGCATCTTTTGCTATTGTT

[0829] GATGCAGTTTCAAAAGCTCAAGATATTCCAGTTACAGGTGCTGTTGATATTGTTTTAGAACAATTGAGA

[0830] GATTTGCATATCGGTCAATCTTATGATATCCATTGGACTAGACATTCATCTTGTCCATCAGAAACAGAATA

[0831] CTTAGAAATGGTTGCTAAGAAAACTGGTGGTTTGTTTAAATTATTGTCTAGATTGATGACTACAGGTTTA

[0832] CCAGATATCACTAAATCAACAATCGATGATTTGGTTACACAATTGGGTATCTATTTCCAAATCAGAGATG

[0833] ATTTCAAGAATTTGAACTCTGATGAATACGCTTCACAAAAAGGTTTCTGTGAAGATTTGGATGAGGGTA

[0834] AATTTTCTTTCCCATTGGTTCATTATTTGACTAAAGGTCAAGAATCTCCACCTTTTATGTTGAGAGAAAT

[0835] CATGCAACAAAGAAGAGAATCTAAGGGTTTGAACGTTCCATCAAAGATGTTGGCTTTGCAACAATTGA

[0836] AGAAATCTGGTTCTTTAGAATACACTCATAGAACATTGAAGAGATTAGAAGTTCAAATTAATCAAATCAT

[0837] TGGTAGATTGGAAAGAATCACTGGTAAAGATAACTGGGTTTTGAGATTGTGTATGGGTGAATTAACAGT

[0838] TTGA

[0839] SEQ ID NO.47

[0840] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTA

[0841] LVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQ

[0842] AKMMYQLARTDKRCAERVKRVWKTMLSTTLKHKSDSFASLEEYLNYRIIDTGGYWVESVMLFGMGMTL

[0843] TEEEDAQLAEVVRPCYASLALANDYFSFDREWEEAQNGGPPPTNAVWLYMRWNGIPMPAAKKLVREASN

[0844] RYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARG

[0845] DGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDT

[0846] KHVAAPFDYVASLPSKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMLDDIEDGSELRRGNPAAH

[0847] AVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKT

[0848] GGLFKLISRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDYKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTK

[0849] GQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[0850] >SEQ ID NO.48

[0851] ATGTGTACTATGGATGATCATACATCTGAATTGTTGGATATCTCACAATTCGATACTCAAGGTTTCTGTCC

[0852] AGGTTATCCATTGAGAAGACATAGATACGAATCTTTAGCAAATTCAGGTTGTTATGAAGCTAGACAAGA

[0853] TTGGATTCATTACGTTGGTCCAGCTGAAGAATTTGGTTCTTGTGATCCAACTAACGGTAACTTCACAGC

[0854] ATTGGTTTTACCATTGACTAAACCAGAAAGATTGCATTTGGTTGCTTACATCATCGAGTGTGAGTTTATT

[0855] AGAGTTTGTACCCATACGCATTTTTGCATGATAATGTGTGTTGAAGCAGTTATGCCAGATTCTTCAACAA

[0856] ACAACGTGACGATTTCCATTTGGGTGAAGCTGAAAAGAGACAAAGAAACGTTAGAATGGGTAGAAA

[0857] GCAAATCCAAGCAAAGATGATGTACCAATTGGCTAGAACTGATAAGAGATGTGCAGAAAGAGTTAAGA

[0858] GAGTTTGGAAGACAATGTTGTCTACTACATTGAAGCATAAGTCAGATTCTTTCGCATCATTGGAAGAATA

[0859] TTTGAACTACAGAATCATCGATACTGGTGGTTACTGGGTTGAATCTGTTATGTTGTTTGGTATGGGTATG

[0860] ACTTTAACAGAAGAAGAAGATGCTCAATTGGCAGAAGTTGTTAGACCATGTTATGCTTCTTTAGCTTTG

[0861] GCAAACGATTACTTCTCATTCGATAGAGAATGGGAAGAAGCTCAAAATGGTGGTCCACCACCAACAAA

[0862] TGCAGTTGGTTGTATATGAGATGGAATGGTATTCCAATGCCAGCTGCTAAGAAATTGGTTAGAGAAGC

[0863] ATCTAACAGATACGAAGCTAGATTTTTAGAATTGTGTGATTCTTTTAGAAGAAACAACCCATTGTACTCA

[0864] GAAAAATTGGATAAATATTTGAGAGGTTTGGCTTACCAAAATTTCTGGTAATGTTGTTTGGTCATTGACTT

[0865] GTCCAAGATATCATCCAGAGTTTAGATACGATCCAAATGCTGGTATGGAAGATTTGTTAACTGCTCAAGC

[0866] TAGAGGTGACGGTGGTGCTGTTTCTGGTGGTGAAGCTGATTACACAGCAGAACATAGACAATCAATCA

[0867] TTTCTTTAGAATCACAACATACTGCTTCTTCAACAAGATATTCAGCATCTGATTGGCAATCTTCAAGATC

[0868] TTCATCTTTTTCTGAAATCTCAGTTGATGGTGAAGATGGTGAAACTCATGCAGTTAAATTGCCAGCTGA

[0869] ACAAGGTTTAGATACAAAACATGTTGCTGCACCATTTGATTATGTTGCTTCTTTGCCATCAAAGGGTGTT

[0870] AGAACTACATTGATCGATGCATTGAATTTGTGGTGTGATTTGCCAGATACTACATTGGCTGGTATTAAAG

[0871] AAGTTGTTGATAAATTGCATACAGCATCTTTAATGTTGGATGATATCGAAGATGGTTCAGAATTGAGAAG

[0872] AGGTAATCCAGCTGCACATGCAGTTTACGGTGTTCCACAAACTATTAATGCTGCATCTTTTGCTATTGTT

[0873] GATGCAGTTTCAAAAGCTCAAGATATTCCAGTTACAGGTGCTGTTGATATTGTTTTAGAACAATTGAGA

[0874] GATTTGCATATCGGTCAATCTTATGATATCCATTGGACTAGACATTCATCTTGTCCATCAGAAACAGAATA

[0875] CTTAGAAATGGTTGCTAAGAAAACTGGTGGTTTGTTTAAATTTCTAGATTGATGACTACAGGTTTA

[0876] CCAGATATCACTAAATCAACAATCGATTTGGTTACACAATTGGGTATCTATTTCCAAATCAGAGATG

[0877] ATTATAAATTTGAACTCTGATGAATACGCTTCACAAAAAGGTTTCTGTGAAGATTTGGATGAGGTA

[0878] AATTTTCTTTCCCATTGGTTCATTATTGACTAAAGGTCAAGAATCTCCACCTTTTATGTTGAGAGAAT

[0879] CATGCAACAAAGAAGAGAATCTAAGGGTTTGAACGTTCCATCAAAGATGTTGGCTTTGCAACAATTGA

[0880] AGAAATCTGGTTCTTTAGAATACACTCATAGAACATTGAAGATTAGAAGTTCAAATTAATCAAATCAT

[0881] TGGTAGATTGGAAAGAATCACTGGTAAAGATAACTGGGTTTTGAGATTGTGTATGGGTGAATTAACAGT

[0882] TTGA

[0883] >SEQ ID NO.49

[0884] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTA

[0885] LVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQQIQ

[0886] AKMMYQLARTDKRCAERVKRVWKTMLSTTLKHKSDSFASLEEYLNYRIIDTGGYWVESVMLFGMGMTL

[0887] TEEEDAQLAEVVRPCYASLALANDYFSFDREWEEAQNGGPPPTNAVWLYMRWNGIPMPAAKKLVREASN

[0888] RYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARG

[0889] DGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDT

[0890] KHVAAPFDYVASLPSKGVRDTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMLDDIEDGSELRRGNPAAH

[0891] AVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKT

[0892] GGLFKLISRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDFKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTK

[0893] GQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[0894] >SEQ ID NO.50

[0895] ATGTGTACTATGGATGATCATACATCTGAATTGTTGGATATCTCACAATTCGATACTCAAGGTTTCTGTCC

[0896] AGGTTATCCATTGAGAAGACATAGATACGAATCTTTAGCAAATTCAGGTTGTTATGAAGCTAGACAAGA

[0897] TTGGATTCATTACGTTGGTCCAGCTGAAGAATTTGGTTCTTGTGATCCAACTAACGGTAACTTCACAGC

[0898] ATTGGTTTTACCATTGACTAAACCAGAAAGATTGCATTTGGTTGCTTACATCATCGAGTGTGAGTTTATT

[0899] AGAGTTTTGTACCCATACGCATTTTTGCATGATAATGTTGTTGAAGCAGTTATGCCAGATTCTTCAACAA

[0900] ACAACGGTGACGATTTCCATTTGGGTGAAGCTGAAAAGAGACAAAGAAACGTTAGAATGGGTAGAAA

[0901] GCAAATCCAAGCAAAGATGATGTACCAATTGGCTAGAACTGATAAGAGATGTGCAGAAAGAGTTAAGA

[0902] GAGTTTGGAAGACAATGTTGTCTACTACATTGAAGCATAAGTCAGATTCTTTCGCATCATTGGAAGAATA

[0903] TTTGAACTACAGAATCATCGATACTGGTGGTTACTGGGTTGAATCTGTTATGTTGTTTGGTATGGGTATG

[0904] ACTTTAACAGAAGAAGAAGATGCTCAATTGGCAGAAGTTGTTAGACCATGTTATGCTTCTTTAGCTTTG

[0905] GCAAACGATTACTTCTCATTCGATAGAGAATGGGAAGAAGCTCAAAATGGTGGTCCACCACCAACAAA

[0906] TGCAGTTTGGTTGTATATGAGATGGAATGGTATTCCAATGCCAGCTGCTAAGAAATTGGTTAGAGAAGC

[0907] ATCTAACAGATACGAAGCTAGATTTTTAGAATTGTGTGATTCTTTTAGAAGAAACAACCCATTGTACTCA

[0908] GAAAAATTGGATAAATATTTGAGAGGTTTGGCTTACCAAATTTCTGGTAATGTTGTTTGGTCATTGACTT

[0909] GTCCAAGATATCATCCAGAGTTTAGATACGATCCAAATGCTGGTATGGAAGATTTGTTAACTGCTCAAGC

[0910] TAGAGGTGACGGTGGTGCTGTTTCTGGTGGTGAAGCTGATTACACAGCAGAACATAGACAATCAATCA

[0911] TTTCTTTAGAATCACAACATACTGCTTCTTCAACAAGATATTCAGCATCTGATTGGCAATCTTCAAGATC

[0912] TTCATCTTTTTCTGAAATCTCAGTTGATGGTGAAGATGGTGAAACTCATGCAGTTAAATTGCCAGCTGA

[0913] ACAAGGTTTAGATACAAAACATGTTGCTGCACCATTTGATTATGTTGCTTCTTTGCCATCAAAGGGTGTT

[0914] AGAGATACATTGATCGATGCATTGAATTTGTGGTGTGATTTGCCAGATACTACATTGGCTGGTATTAAAG

[0915] AAGTTGTTGATAAATTGCATACAGCATCTTTAATGTTGGATGATATCGAAGATGGTTCAGAATTGAGAAG

[0916] AGGTAATCCAGCTGCACATGCAGTTTACGGTGTTCCACAAACTATTAATGCTGCATCTTTTGCTATTGTT

[0917] GATGCAGTTTCAAAAGCTCAAGATATTCCAGTTACAGGTGCTGTTGATATTGTTTTAGAACAATTGAGA

[0918] GATTTGCATATCGGTCAATCTTATGATATCCATTGGACTAGACATTCATCTTGTCCATCAGAAACAGAATA

[0919] CTTAGAAATGGTTGCTAAGAAAACTGGTGGTTTGTTTAAATTAATTTCTAGATTGATGACTACAGGTTTA

[0920] CCAGATATCACTAAATCAACAATCGATGATTTGGTTACACAATTGGGTATCTATTTCCAAATCAGAGATG

[0921] ATTTCAAGAATTTGAACTCTGATGAATACGCTTCACAAAAAGGTTTCTGTGAAGATTTGGATGAGGGTA

[0922] AATTTTCTTTCCCATTGGTTCATTATTTGACTAAAGGTCAAGAATCTCCACCTTTTATGTTGAGAGAAAT

[0923] CATGCAACAAAGAAGAGAATCTAAGGGTTTGAACGTTCCATCAAAGATGTTGGCTTTGCAACAATTGA

[0924] AGAAATCTGGTTCTTTAGAATACACTCATAGAACATTGAAGAGATTAGAAGTTCAAATTAATCAAATCAT

[0925] TGGTAGATTGGAAAGAATCACTGGTAAAGATAACTGGGTTTTGAGATTGTGTATGGGTGAATTAACAGT

[0926] TTGA

[0927] SEQ ID NO.51

[0928] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTA

[0929] LVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQ

[0930] AKMMYQLARTDKRCAERVKRVWKTMLSTTLKHKSDSFASLEEYLNYRIIDTGGYWVESVMLFGMGMTL

[0931] TEEEDAQLAEVVRPCYASLALANDYFSFDREWEEAQNGGPPPTNAVWLYMRWNGIPMPAAKKLVREASN

[0932] RYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARG

[0933] DGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDT

[0934] KHVAAPFDYVASLPSKGVRDTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMFDDIEDGSELRRGNPAAH

[0935] AVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKT

[0936] GGLFKLISRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDYKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTK

[0937] GQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[0938] >SEQ ID NO.52

[0939] ATGTGTACTATGGATGATCATACATCTGAATTGTTGGATATCTCACAATTCGATACTCAAGGTTTCTGTCC

[0940] AGGTTATCCATTGAGAAGACATAGATACGAATCTTTAGCAAATTCAGGTTGTTATGAAGCTAGACAAGA

[0941] TTGGATTCATTACGTTGGTCCAGCTGAAGAATTTGGTTCTTGTGATCCAACTAACGGTAACTTCACAGC

[0942] ATTGGTTTTACCATTGACTAAACCAGAAAGATTGCATTTGGTTGCTTACATCATCATCGAGGTGTGAGTTTATT

[0943] AGAGTTTGTACCCATACGCATTTTTGCATGATAATGTGTGTTGAAGCAGTTATGCCAGATTCTTCAACAA

[0944] ACAACGTGACGATTTCCATTTGGGTGAAGCTGAAAAGAGACAAAGAAACGTTAGAATGGGTAGAAA

[0945] GCAAATCCAAGCAAAGATGATGTACCAATTGGCTAGAACTGATAAGAGATGTGCAGAAAGAGTTAAGA

[0946] GAGTTTGGAAGACAATGTTGTCTACTACATTGAAGCATAAGTCAGATTCTTTCGCATCATTGGAAGAATA

[0947] TTTGAACTACAGAATCATCGATACTGGTGGTTACTGGGTTGAATCTGTTATGTTGTTTGGTATGGGTATG

[0948] ACTTTAACAGAAGAAGAAGATGCTCAATTGGCAGAAGTTGTTAGACCATGTTATGCTTCTTTAGCTTTG

[0949] GCAAACGATTACTTCTCATTCGATAGAGAATGGGAAGAAGCTCAAAATGGTGGTCCACCACCAACAAA

[0950] TGCAGTTTGGTTGTATATGAGATGGAATGGTATTCCAATGCCAGCTGCTAAGAAATTGGTTAGAGAAGC

[0951] ATCTAACAGATACGAAGCTAGATTTTTAGAATTGTGTGATTCTTTTAGAAGAAACAACCCATTGTACTCA

[0952] GAAAAATTGGATAAATATTTGAGAGGTTTGGCTTACCAAATTTCTGGTAATGTTGTTTGGTCATTGACTT

[0953] GTCCAAGATATCATCCAGAGTTTAGATACGATCCAAATGCTGGTATGGAAGATTTGTTAACTGCTCAAGC

[0954] TAGAGGTGACGGTGGTGCTGTTTCTGGTGGTGAAGCTGATTACACAGCAGAACATAGACAATCAATCA

[0955] TTTCTTTAGAATCACAACATACTGCTTCTTCAACAAGATATTCAGCATCTGATTGGCAATCTTCAAGATC

[0956] TTCATCTTTTTCTGAAATCTCAGTTGATGGTGAAGATGGTGAAACTCATGCAGTTAAATTGCCAGCTGA

[0957] ACAAGGTTTAGATACAAAACATGTTGCTGCACCATTTGATTATGTTGCTTCTTTGCCATCAAAGGGTGTT

[0958] AGAGATACATTGATCGATGCATTGAATTTGTGGTGTGATTTGCCAGATACTACATTGGCTGGTATTAAAG

[0959] AAGTTGTTGATAAATTGCATACAGCATCTTTAATGTTCGATGATATCGAAGATGGTTCAGAATTGAGAAG

[0960] AGGTAATCCAGCTGCACATGCAGTTTACGGTGTTCCACAAACTATTAATGCTGCATCTTTTGCTATTGTT

[0961] GATGCAGTTTCAAAAGCTCAAGATATTCCAGTTACAGGTGCTGTTGATATTGTTTTAGAACAATTGAGA

[0962] GATTTGCATATCGGTCAATCTTATGATATCCATTGGACTAGACATTCATCTTGTCCATCAGAAACAGAATA

[0963] CTTAGAAATGGTTGCTAAGAAAACTGGTGGTTTGTTTAAATTAATTTCTAGATTGATGACTACAGGTTTA

[0964] CCAGATATCACTAAATCAACAATCGATGATTTGGTTACACAATTGGGTATCTATTTCCAAATCAGAGATG

[0965] ATTATAAGAATTTGAACTCTGATGAATACGCTTCACAAAAAGGTTTCTGTGAAGATTTGGATGAGGGTA

[0966] AATTTTCTTTCCCATTGGTTCATTATTTGACTAAAGGTCAAGAATCTCCACCTTTTATGTTGAGAGAAAT

[0967] CATGCAACAAAGAAGAGAATCTAAGGGTTTGAACGTTCCATCAAAGATGTTGGCTTTGCAACAATTGA

[0968] AGAAATCTGGTTCTTTAGAATACACTCATAGAACATTGAAGAGATTAGAAGTTCAAATTAATCAAATCAT

[0969] TGGTAGATTGGAAAGAATCACTGGTAAAGATAACTGGGTTTTGAGATTGTGTATGGGTGAATTAACAGT

[0970] TTGA

[0971] >SEQ ID NO.53

[0972] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTA

[0973] LVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQ

[0974] AKMMYQLARTDKRCAERVKRVWKTMLSTTLKDKSDSFASLEEYLNYRIIDTGAYWVESVMLFGMGMTL

[0975] TEEEDAQLAEVVRPCYASLALANDYFSFDREWEEAQNGGPPPTNAVWLYMRWNGIPMPAAKKLVREASN

[0976] RYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARG

[0977] DGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDT

[0978] KHVAAPFDYVASLPSKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMLDDIEDGSELRRGNPAAH

[0979] AVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKT

[0980] GGLFKLISRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDYKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTK

[0981] GQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[0982] SEQ ID NO.54

[0983] ATGTGTACTATGGATGATCATACATCTGAATTGTTGGATATCTCACAATTCGATACTCAAGGTTTCTGTCC

[0984] AGGTTATCCATTGAGAAGACATAGATACGAATCTTTAGCAAATTCAGGTTGTTATGAAGCTAGACAAGA

[0985] TTGGATTCATTACGTTGGTCCAGCTGAAGAATTTGGTTCTTGTGATCCAACTAACGGTAACTTCACAGC

[0986] ATTGGTTTTACCATTGACTAAACCAGAAAGATTGCATTTGGTTGCTTACATCATCATCGAGGTGTGAGTTTATT

[0987] AGAGTTTGTACCCATACGCATTTTTGCATGATAATGTGTGTTGAAGCAGTTATGCCAGATTCTTCAACAA

[0988] ACAACGTGACGATTTCCATTTGGGTGAAGCTGAAAAGAGACAAAGAAACGTTAGAATGGGTAGAAA

[0989] GCAAATCCAAGCAAAGATGATGTACCAATTGGCTAGAACTGATAAGAGATGTGCAGAAAGAGTTAAGA

[0990] GAGTTTGGAAGACAATGTTGTCTACTACATTGAAGGATAAGTCAGATTCTTTCGCATCATTGGAAGAATA

[0991] TTTGAACTACAGAATCATCGATACTGGTGCTTACTGGGTTGAATCTGTTATGTTGTTTGGTATGGGTATG

[0992] ACTTTAACAGAAGAAGAAGATGCTCAATTGGCAGAAGTTGTTAGACCATGTTATGCTTCTTTAGCTTTG

[0993] GCAAACGATTACTTCTCATTCGATAGAGAATGGGAAGAAGCTCAAAATGGTGGTCCACCACCAACAAA

[0994] TGCAGTTTGGTTGTATATGAGATGGAATGGTATTCCAATGCCAGCTGCTAAGAAATTGGTTAGAGAAGC

[0995] ATCTAACAGATACGAAGCTAGATTTTTAGAATTGTGTGATTCTTTTAGAAGAAACAACCCATTGTACTCA

[0996] GAAAAATTGGATAAATATTTGAGAGGTTTGGCTTACCAAATTTCTGGTAATGTTGTTTGGTCATTGACTT

[0997] GTCCAAGATATCATCCAGAGTTTAGATACGATCCAAATGCTGGTATGGAAGATTTGTTAACTGCTCAAGC

[0998] TAGAGGTGACGGTGGTGCTGTTTCTGGTGGTGAAGCTGATTACACAGCAGAACATAGACAATCAATCA

[0999] TTTCTTTAGAATCACAACATACTGCTTCTTCAACAAGATATTCAGCATCTGATTGGCAATCTTCAAGATC

[1000] TTCATCTTTTTCTGAAATCTCAGTTGATGGTGAAGATGGTGAAACTCATGCAGTTAAATTGCCAGCTGA

[1001] ACAAGGTTTAGATACAAAACATGTTGCTGCACCATTTGATTATGTTGCTTCTTTGCCATCAAAGGGTGTT

[1002] AGAACTACATTGATCGATGCATTGAATTTGTGGTGTGATTTGCCAGATACTACATTGGCTGGTATTAAAG

[1003] AAGTTGTTGATAAATTGCATACAGCATCTTTAATGTTGGATGATATCGAAGATGGTTCAGAATTGAGAAG

[1004] AGGTAATCCAGCTGCACATGCAGTTTACGGTGTTCCACAAACTATTAATGCTGCATCTTTTGCTATTGTT

[1005] GATGCAGTTTCAAAAGCTCAAGATATTCCAGTTACAGGTGCTGTTGATATTGTTTTAGAACAATTGAGA

[1006] GATTTGCATATCGGTCAATCTTATGATATCCATTGGACTAGACATTCATCTTGTCCATCAGAAACAGAATA

[1007] CTTAGAAATGGTTGCTAAGAAAACTGGTGGTTTGTTTAAATTAATTTCTAGATTGATGACTACAGGTTTA

[1008] CCAGATATCACTAAATCAACAATCGATGATTTGGTTACACAATTGGGTATCTATTTCCAAATCAGAGATG

[1009] ATTATAAGAATTTGAACTCTGATGAATACGCTTCACAAAAAGGTTTCTGTGAAGATTTGGATGAGGGTA

[1010] AATTTTCTTTCCCATTGGTTCATTATTTGACTAAAGGTCAAGAATCTCCACCTTTTATGTTGAGAGAAAT

[1011] CATGCAACAAAGAAGAGAATCTAAGGGTTTGAACGTTCCATCAAAGATGTTGGCTTTGCAACAATTGA

[1012] AGAAATCTGGTTCTTTAGAATACACTCATAGAACATTGAAGAGATTAGAAGTTCAAATTAATCAAATCAT

[1013] TGGTAGATTGGAAAGAATCACTGGTAAAGATAACTGGGTTTTGAGATTGTGTATGGGTGAATTAACAGT

[1014] TTGA

[1015] >SEQ ID NO.55

[1016] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTA

[1017] LVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQ

[1018] AKMMYQLARTDKRCAERVKRVWKTMLSTTLKHKSDSFASLEEYLNYRIIDTGGYFVESVMLFGMGMTLT

[1019] EEEDAQLAEVVRPCYASLALANDYFSFDREWEEAQNGGPPLTNAVWLYMRWNGIPMPAAKKLVREASNR

[1020] YEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARGD

[1021] GGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDTK

[1022] HVAAPFDYVASLPSKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMLDDIEDGSELRRGNPAAHA

[1023] VYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKTG

[1024] GLFKLLSRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDFKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTKG

[1025] QESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[1026] >SEQ ID NO.56

[1027]

[1028] >SEQ ID NO.57

[1029] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTALVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQAKMMYQLARTDKRCAERVKRVWKTMLSTTLKHKSDSFASLEEYLNYRIIDTGGYFVESVMLFGMGMTLTEEEDAQLAEVVRPCYASLALANDYFSFDREWEEAQNGGPPLTNAVWLYMRWNGIPMPAAKKLVREASNRYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARGDGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDTKHVAAPFDYVASLPSKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMLDDIEDGSELRRGNPAAHAVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKTGGLFKLISRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDYKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTKGQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[1030] >SEQ ID NO.58

[1031]

[1032] >SEQ ID NO.59

[1033] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTALVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQAKMMYQLARTDKRCAERVKRVWKTMLSTTLKHKSDSFASLEEYLNYRIIDTGGYWVESVMLFGMGMTLTEEEDAQLAEVVRPCYAALALANDYFSFDREWEEAQNGGPPLTNAVWLYMRWNGIPMPAAKKLVREASNRYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARGDGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDTKHVAAPFDYVASLPSKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMLDDIEDGSELRRGNPAAHAVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKTGGLFKLLSRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDFKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTKGQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[1034] >SEQ ID NO.60

[1035]

[1036] >SEQ ID NO.61

[1037] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQDWIHYVGPAEEFGSCDPTNGNFTALVLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPDSSTNNGDDFHLGEAEKRQRNVRMGRKQIQAKMMYQLARTDKRCAERVKRVWKTMLSTTLKHKSDSFASLEEYLNYRIIDTGGYWVESVMLFGMGMTLTEEEDAQLAEVVRPCYAALALANDYFSFDREWEEAQNGGPPLTNAVWLYMRWNGIPMPAAKKLVREASNRYEARFLELCDSFRRNNPLYSEKLDKYLRGLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARGDGGAVSGGEADYTAEHRQSIISLESQHTASSTRYSASDWQSSRSSSFSEISVDGEDGETHAVKLPAEQGLDTKHVAAPFDYVASLPSKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKLHTASLMLDDIEDGSELRRGNPAAHAVYGVPQTINAASFAIVDAVSKAQDIPVTGAVDIVLEQLRDLHIGQSYDIHWTRHSSCPSETEYLEMVAKKTGGLFKLISRLMTTGLPDITKSTIDDLVTQLGIYFQIRDDYKNLNSDEYASQKGFCEDLDEGKFSFPLVHYLTKGQESPPFMLREIMQQRRESKGLNVPSKMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[1038] >SEQ ID NO.62

[1039]

[1040] >SEQ ID NO.63

[1041] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCSEARQDWIHYVGPAEDFGSCDPTNGNFTLLVEPVTKPEREHLVAYIIECEFIRVLYPYAFLHDNVVEAVMPESSTNQGDDFHLGEAEKRQRNVRMGRKQIQAKMMYQLARTDKRCAERVKRVWKTMLSTTLKHKSDSFASLEEYLWYRIIDTGGYWVESVMLFGMGMTLTEEEDAQLAEVVRPCYASLALANDYFSFDREWEEAQPGGPPPTNAVWLYMRWNGIPMPAAKKEVREASNRYEARFLELMDSFPRNNPLYSEKLDCYLRGLAYQISGNVVWSLTCPSYHPEFRFDPNAGGEDLLTAQARIDGGAVSGGEADYTAEHRQSIISLESQHTHSSTRYSASAWQSSRCSSFSEISVDGEDGETHAVKLPAEQGLDTKHVAAPFDYVASLPNKGVRTTLIDALNLWCDLPDTTLAGIKEVVDKWHTASYMFDDIEDGSECRRGNPAAHAVYGVPQTIRAASFAIHDAVKKAQDIPVTGGVDIVLEQLRDLHIGQYYDIHWTRHSSCPSETEYLEMVAKKTGGLFKLISRLMTTGLPDITKSTIDDLVTMLGIYFQIRDDFKNLNSDEYASQKGFCEDLDEGKFIFPLVHYLTKGQESPPFMLREIMQQRRFSKGLNVPSAMLALQQLKKSGSLEYTHRTLKFLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[1042] >SEQ ID NO.64

[1043]

[1044] >SEQ ID NO.65

[1045] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQVWIIYVGPAEEFGSCDPTNGNFTALVLPLTKPERLHLVAVIIECEFIRVWYPYAFLHDNVVEAVFPDSSTNEGDDFHLGEAECRQRNVRWGRKQIQAKMMYDLARQDKRCAERVKRVWKTMLSTTLKHKSDSFASLECYLNYRIIDTGGYWHESVMLFGMGMTLTEEEDAQLARVVRPCYASLALANDYFSFDREWEEAQNGGPPPTNAVWLYMRWNGIFMPAAKKLVREASNRYEARFLELCDSFRVNNPLYSEKLDKYLRGLAYQRSGNVVWSKRCPRYHPSFRYDPFAWMEDLLTAQAPGDGGAVSGGEADYTAEHRQSIISRESQHTASKTGYSASDWQSSRSSHFSEISVDGEDGETHAVKLPAEQGLDTKHVKSPFSYVYSLPTKGVRTTLIVALNLWCDLPDTTLAGIKEVVDKLHTASVTFDDIEDGSELRRGNPAAHA

[1046] VTGRPQTINAASFAIVDCVSKAQDIPVTSNVDIVLEQLRDLHIQQSYDIHWTRQSSCPSETEYLEMVAKKTG

[1047] GLFKLISRLMTTQLPDITKSTIDDLVWQDGIYFQIRDDFKNLNSDEYASRKGFCEDLDEGRFRNPLVHYLTK

[1048] GQESPPFMLREIMQQRRESKGLNVPSKMLAVQQLKKSGSLEYTHRTAKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[1049] >SEQ ID NO.66

[1050] ATGTGTACAATGGACGATCATACTTCAGAATTATTAGATATCTCTCAATTCGATACACAAGGATTTTGTCC

[1051] TGGCTATCCGTTGAGAAGACATAGATATGAATCATTGGCGAACAGCGGCTGCTATGAGGCAAGGCAAGT

[1052] TTGGATAATATACGTTGGTCCGGCAGAGGAATTTGGTAGTTGTGATCCTACTAATGGAAATTTCACTGCA

[1053] CTGGTATTGCCATTAACCAAACCTGAAAGATTACACCTAGTAGCAGTTATTATTGAATGCGAATTTATCA

[1054] GAGTATGGTACCCTTACGCTTTCTTGCACGATAATGTCGTCGAGGCTGTTTTCCCCGATTCTTCAACTAA

[1055] TGAAGGCGATGATTTTCATTTAGGTGAAGCTGAGTGTCGTCAAAGAAACGTCAGATGGGGAAGGAAGC

[1056] AAATTCAAGCGAAAATGATGTATGATCTAGCGAGACAAGATAAAAGGTGCGCTGAAAGGGTTAAGAGG

[1057] GTATGGAAGACTATGTTATCTACGACACTAAAGCATAAATCTGATAGTTTTGCATCCCTGGAATGCTATCT

[1058] AAACTACAGAATTATTGACACCGGGGGATATTGGCACGAATCTGTCATGCTATTTGGTATGGGCATGACA

[1059] CTAACAGAAGAGGAAGATGCTCAGTTAGCTAGGGTGGTTAGACCGTGCTACGCATCCTTAGCTCTTGCG

[1060] AACGATTATTTTAGTTTCGATCGTGAATGGGAGGAAGCTCAGAATGGAGGGCCTCCTCCAACTAATGCC

[1061] GTATGGTTGTACATGAGATGGAATGGCATTTTCATGCCAGCCGCAAAAAAATTAGTCCGTGAAGCAAGC

[1062] AATAGATACGAAGCACGTTTTTTGGAATTGTGTGATTCCTTCAGAGTAAATAACCCTTTATATTCTGAGA

[1063] AATTGGACAAATACCTTAGGGGACTTGCTTATCAAAGATCTGGCAATGTTGTATGGTCTAAAAGGTGTC

[1064] CCAGATATCATCCCTCATTTAGATACGATCCATTTGCTTGGATGGAAGATTTGCTAACAGCCCAGGCTCC

[1065] GGGAGATGGAGGTGCAGTGTCTGGTGGTGAAGCTGACTACACGGCTGAACATAGACAATCCATAATAT

[1066] CTAGAGAGTCTCAGCATACAGCTTCTAAAACGGGCTATAGTGCAAGTGACTGGCAATCCTCAAGAAGC

[1067] TCTCATTTCAGTGAAATATCCGTAGACGGTGAAGATGGTGAGACGCACGCAGTTAAGTTGCCTGCCGA

[1068] ACAGGGGTTGGATACAAAGCACGTGAAGTCACCCTTCTCATACGTATATTCATTACCTACAAAGGGGGT

[1069] GAGAACAACCTTGATTGTTGCTTTGAATTTGTGGTGCGACCTTCCAGATACAACATTGGCTGGTATAAA

[1070] AGAAGTGGTTGATAAGTTGCACACAGCTTCCGTAACTTTCGACGATATCGAAGATGGTTCTGAGCTTAG

[1071] AAGGGGGAACCCAGCTGCTCATGCCGTTACAGGGTAGGCCACAAACGATTAACGCTGCTTCATTTGCTAT

[1072] AGTGGACTGCGTCTCTAAGGCCCAAGACATCCCGGTAACTTCTAACGTTGATAATTGTGTTGGAACAATT

[1073] GAGGGATCTGCACATTCAACAAAGCTACGACATACATTGGACCAGACAATCCTCCTGTCCTTCCGAAAC

[1074] TGAATATTTGGAAATGGTCGCAAAAAGACCGGAGGATTGTTCAAATTGATATCTCGTCTGATGACTAC

[1075] CCAATTACCAGATATCCACAAATCAACGATAGATGACTTGGTGTGGCAGGATGGTATATATTTCCAAATA

[1076] AGGGATGACTTCAAGAATCTGAATTCAGATGAATACGCATCTAGAAAGGGCTTTTGTGAAGACTTGGAT

[1077] GAGGGAAGATTTAGAAACCCATTAGTTCACTATTTGACAAAGGGGCAGGAATCTCCTCCATTTATGTTG

[1078] AGAGAAATCATGCAACAAAGGAGGGAGAGTAAAGGTCTAAATGTACCAAGCAAGATGTTGGCTGTTC

[1079] AACAATTGAAGAAATCTGGTAGCTTGGAATATACTCACAGAACTGCAAAACGTTTGGAAGTACAGATT

[1080] AATCAAATCATAGGTAGGCTAGAAAGATTACAGGAAAAGATAATTGGGTCCTACGTTTGTGCATGGGG

[1081] GAATTGACTGTT

[1082] >SEQ ID NO.67

[1083] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHLYESLANSGCYEARQDFKSYVGPAEELGSCDPTTGNFYAL

[1084] VLPLTKPERLHLVAYIIECEFIRVLYPYAFLHDNVVEACMPDSSTNNGDDFHIGEAEKRQRNVRMGMTQCQ

[1085] AKVDAQLARTDKRCAERVDNVWKTMLSTTLKHKSDSFASLEEYLNYRIIDTQGYWVMSVMLFGMGMTL

[1086] TEEEDAQLAEVWRPCYASLALASDYFSFDREWEEAQNGIPPPTNAVWLYMRWKGIPMPAAKKLVREAQH

[1087] WYEARFLEIDDSFRRINPLYSEKLDKYPRNLAYQISGNVVWSLTCPRYHPEFRYDPNAGMEDLLTAQARGD

[1088] GGAVHGGEADYSAEHTQSIISLESQATASSTRYSASDWQSSRSSQFHEISVDGEDQETHAVKLPAEQGLDTK

[1089] HYAAPFDQVASTKSKGVRTTLIDALNLWCDLPDTTLAGIKEVNCKLHTRSLMFDDIEDGSELRRGNPAAYA

[1090] VYGVPMTIFAASFAIVDAVSKAQDILVTGAVDIVLEQLRDFHIGQSYDIHWTRTSSCPSETNYLEMVAKKTG

[1091] GLQILISRLMTTGLGDITKSTIDYKVTQLGIYFQIRDDFKNLNSDEKAAQKVFCEDLDEGKFSFPLVKYLTK

[1092] GQESPPHMLREIMQQRRESKGLNMPSPMLALQQLKKSGSLEYTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[1093] SEQ ID NO.68

[1094] ATGTGTACAATGGACGACCATACCTCCGAATTATTAGATATATCTCAATTTGATACACAAGGTTTCTGTCC

[1095] GGGTTATCCATTGAGAAGACACCTTTACGAGTCTTTAGCTAATTCTGGGTGTTATGAGGCTAGACAAGA

[1096] TTTTAAGAGCTATGTTGGTCCCGCAGAGGAATTGGGTTCTTGTGATCCGACTACTGGCAATTTCTATGCT

[1097] TTGTCTTACCACTGACGAAGCCAGAAAGATTGCATCTGGTTGCTTACATCATCGAATGTGAGTTTATTA

[1098] GGGTGCTATATCCATACGCGTTTCTACACGATAACGTCGTTGAAGCCTGCATGCCGGATTCATCTACAAA

[1099] CAACGGTGATGATTTTCACATTGGTGAGGCTGAGAAAAGACAAAGAAATGTAAGAATGGGGATGACAC

[1100] AATGTCAAGCAAAAGTTGATGCTCAGTTGGCAAGAACTGATAAGAGATGCGCTGAGAGAGTTGACAAT

[1101] GTGTGGAAAACGATGTTAAGTACAACCTTAAAGCATAAATCAGATAGTTTTGCATCTTTAGAAGAGTAT

[1102] CTGAACTATAGAATAATTGATACTCAAGGCTACTGGGTGATGAGCGTGATGTTATTTGGCATGGGCATGA

[1103] CTTTGACAGAAGAAGAAGATGCACAACTTGCAGAAGTCTGGAGACCTTGTTATGCGAGCTTGGCTTTA

[1104] GCGTCCGATTATTTCTCCTTTGATAGAGAATGGGAAGAGGCCCAAAATGGTATTCCGCCGCCCACAAAT

[1105] GCTGTCTGGCTATATATGCGTTGGAAAGGTATCCCAATGCCCGCAGCTAAAAAATTAGTTAGAGAAGCA

[1106] CAACACTGGTACGAGGCGAGGTTTCTAGAAATCGATGATTCTTTTAGACGTATTAATCCACTTTACTCCG

[1107] AAAAGTTGGACAAATATCCCAGGAACCTAGCCTACCAAATCTCAGGCAACGTCGTGTGGTCTTTAACAT

[1108] GTCCAAGATACCATCCAGAGTTCAGGTACGATCCAAATGCAGGAATGGAAGACTTGCTTACAGCACAA

[1109] GCGAGGGGAGATGGTGGTGCCGTTCACGGAGGCGAGGCTGATTATTCTGCTGAGCACACACAAAGTAT

[1110] CATTAGCTTAGAAAGTCAAGCTACAGCATCTAGCACAAGATATTCCGCCTCTGATTGGCAATCATCAAG

[1111] ATCTTCTCAGTTTCATGAAATTTCAGTTGACGGCGAAGATCAAGAAACTCACGCAGTCAAATTGCCTGC

[1112] AGAACAAGGTTTGGATACTAAGCACTATGCAGCTCCGTTCGATCAAGTTGCTAGTACTAAATCCAAAGG

[1113] AGTCAGGACAACATTAATAGATGCATTGAACCTGTGGTGTGACTTACCGGACACTACACTTGCGGGAAT

[1114] CAAAGAGGTCAATTGTAAATTGCACACCAGGTCCTTGATGTTCGACGACATTGAGGACGGTTCTGAAC

[1115] TAAGAAGAGGCAATCCTGCAGCTTACGCAGTCTATGGGGTACCTATGACGATTTTTGCTGCCTCTTTTGC

[1116] GATTGTTGACGCTGTAAGTAAGGCCCAAGATATCTTGGTCACCGGTGCCGTAGATATTGTTTTGGAGCA

[1117] ATTGAGGGACTTTCATATTGGCCAAAGTTACGATATCCATGGACTAGAACCTCCTCATGCCCAAGCGA

[1118] AACTAATTATTGGAAATGGTTGCTAAAAAGACAGGTGGTTTGCAGATTTTGATTTCTAGACTAATGACC

[1119] ACTGGTTTAGGTGATATAACGAAATCTACCATAGATTATAAGGTTACACAGCTTGGCATCTATTTTCAGAT

[1120] AAGAGATGACTTTAAGAATCTGAATTCCGACGAAAAAGCCGCCCAAAAAGTTTTTTGTGAGGATTTGG

[1121] ACGAAGGCAAGTTTTCTTTTCCCTTGGTGAATATTTGACCAAGGGACAAGAAAGCCCTCCTCACATG

[1122] CTGAGAGAGATTATGCAACAAAGAAGAATCTAAAGGTTTGAACATGCCTAGCCCGATGCTGGCTCT

[1123] GCAAACGTTGAAAAGTCTGGCAGCTTAGAATACACTCATCGTACCTTGAAGAGATTAGATAGAGA

[1124] TAAACCAAATCATAGGGAGGTTAGAGAGAATAACAGGGAAAGATAACTGGGTTTTGAGATTATGTATGG

[1125] GGGAATTAACAGTT

[1126] >SEQ ID NO.69

[1127] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRPESLANSGCYEFRPDWIHYVGKAEQFGSCDPFTGGFTA

[1128] MVLPLTAPERLHLVAYIIEAEFIRVLYPYTFLHDNVVEAVMPDSSTNNGEDFHLGEEEKRQRHCRMGRKQIQ

[1129] CKMMYQLARTDKRCAEHVKDVWQVMLSTTLKHKSDSYASLEEYLNYRIIDTGGYWCESVPLFGMRMTL

[1130] TVEEDAQLAHVVRPCYASLACANDYFSFDREWEEAYNGGPPPTQAVWLYMRWNGIPMPAAKKLVREVSL

[1131] RGEARFLELCDSFRRNNQLYSSKLDYYLRAQAYQISGNVVWSLTCPRYHPYFSYDPNAGMEDLLTAQARG

[1132] QGGAYSGGEYDYTNEHRQSIISLESQHTASSTRYSTSDWQSSRSISESHISVDGEIGETHAVKLPAEQGLDTK

[1133] HVAALFDYVASLPSKGVRTMLIDAVNLWCDLPDTTLSGIHEVVDKLHTASLMFDDIEDGEELRMQNPASH

[1134] AEYGVPQTMNAASFAIVHAVSKAQDIPVTGAVDSVLEQLRDLNFGQSYDHHWTRHSSCPSETEYLEQMAK

[1135] KTNGLFKLISRLMTTGLPDIDSSWIDDLVTQLGIYFQIRDDFKNLNSDEYASQMGFCEDLDEGKFQFPLVHY

[1136] LGKGQESTPIMLREIMQQRRGSKGLPVPSKMLALQQLKKSGSLEYTHRTLERLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[1137] >SEQ ID NO.70

[1138] ATGTGTACAATGGACGATCATACCTCAGAACTGTTAGATATATCCCAATTCGATACTCAAGGTTTTTGTCC

[1139] AGGGTATCCACTTAGAAGACATAGGCCGGAGTCCTTAGCTAACAGTGGTTGTTACGAATTCAGACCTGA

[1140] CTGGATTCACTACGTCGGTAAGGCTGAGCAGTTTGGTAGCTGTGATCCGTTTACAGGTGGTTTCACAGC

[1141] CATGGTCTTACCCTTGACTGCTCCAGAAAGATTGCACTTGGTAGCTTATATTATTGAAGCTGAGTTCATC

[1142] AGGGTGTTATACCCCTATACCTTTCTACACGATAATGTTGTAGAAGCCGTGATGCCAGATTCCTCTACAA

[1143] ATAATGGCGAAGACTTCCATTTGGGTGAAGAAGAGAAGAGACAGAGGCATTGCAGAATGGGTAGGAA

[1144] GCAAATCCAATGTAAAATGATGTATCAACTAGCACGTACAGACAAAAGATGTGCCGAACACGTAAAAG

[1145] ATGTTTGGCAAGTGATGTTGAGCACCACACTTAAACATAAATCCGATAGTTACGCCAGTCTAGAAGAAT

[1146] ATCTAAATTATAGGATCATTGATACCGGGGGTTACTGGTGTGAATCCGTTCCATTGTTTGGCATGCGTATG

[1147] ACCCTGACAGTAGAAGAATGCACAGTTGGCACATGTTGTAAGACCTTGTTACGCATCACTTGCTTGT

[1148] GCAAATGACTATTTCTCATTTGACAGGGAATGGGAGGGAAGCGTACAATGGTGGTCCTCCTCCACCCAA

[1149] GCGGTGTGGTTTATATAGAGATGGAACGGTATCCAATGCCGGCAGCAAAAAGTTGGTTAGAGAAGTT

[1150] TCTTTAAGAGGGGAAGCGAGATTTCTAGAATTGTGTGACTCTTTCCGTAGGAACAACCAGTTATATTCC

[1151] TCAAAATTGGATTACTATTTAAGAGCTCAAGCTTACCAGATCTCCGGTAACGTCGTTTGGTCATTAACCT

[1152] GCCCAAGATATCACCCATACTTTAGTTATGATCCGAACGCTGGCATGGAAGATCTATTAACGCTCAAGC

[1153] AAGAGGTCAAGGCGGTGCTTATTCAGGTGGTGAGTACGACTACAAAATGAACACAGACAATCCATTA

[1154] TTTCATTAGAATCCAACATACCGCCTCTAGCACAAGATATGCACTTCAGATTGGCAATCATCAAGGAG

[1155] CATATCCGAGTCACATATCTCAGTAGATGGTGAAATCGGTGAAACACATGCCGTTAAACTACCAGCTGA

[1156] ACAGGGCTTGGACACCAAGCATGTCGCTGCGTTATTCGACTATGTAGCCTCTTTGCCTTCTAAGGGTGT

[1157] TAGGACAATGTTGATAGATGCAGTGAATCTTTGGTGTGACTTACCAGATACAACCTTGAGTGGTATTCAT

[1158] GAAGTTGTGGACAAGCTGCATACCGCATCACTAATGTTCGACGATATTGAGGATGGTGAAGAATTAAGA

[1159] ATGCAGAACCCAGCTAGTCATGCAGAATATGGTGTACCCCAAACAATGAACGCCGCTTCCTTTGCAATA

[1160] GTCCATGCTGTTAGTAAAGCACAGGATATACCAGTCACAGGTGCCGTGGATTCCGTTTTGGAGCAGTTA

[1161] AGAGACTTAAATTTTGGGCAGTCTTATGATCACCATTGGACAAGACATTCAAGTTGTCCATCTGAAACT

[1162] GAATACCTTGAACAAATGGCTAAGAAAACAAACGGATTGTTCAAATTAATAAGCAGATTAATGACAAC

[1163] GGGCTTACCAGATATCGATAGTTCTTGGATCGATGACTTGGTAACCCAATTAGGCATATATTTTCAAATTC

[1164] GTGACGATTTCAAGAACTTGAACAGCGATGAATACGCGAGTCAAATGGGATTTTGTGAGGATTTGGAT

[1165] GAAGGTAAATTTCAATTCCCACTGGTCCATTACCTGGGAAAGGGTCAAGAATCTACGCCAATTATGCTA

[1166] AGGGAAATAATGCAACAGAGGAGGGGTTCAAAGGGCTTGCCCGTCCCCAGCAAAATGTTAGCGTTGC

[1167] AACAACTGAAGAAGAGCGGTTCATTAGAGTATACTCATAGAACACTTGAACGTTTAGAGGTTCAGATA

[1168] AATCAGATCATTGGGAGATTGGAAAGAATAACAGGAAAGGATAACTGGGTATTGCGTCTTTGCATGGGT

[1169] GAATTGACAGTT

[1170] >SEQ ID NO.71

[1171] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYAGLANSGCYEARQDWIHYVIPAEEFGSCDPTNGTFTAL

[1172] VLWLTKPERLHLVKCIIECLFIRGLYPYAFLHDNVVEAVMPDIITNNGDWFHLKEAEFRQRNVREGRKQTD

[1173] NKMMYQDARSDARDAERVKRVWKTMLSTTLKHKSFSFASLEEYLNYRIIDTGGYWVESVWLFGMGMTL

[1174] TEEEDAQLAETQRPCYASLALAIDYFSFDREWEEAQNGGPPPPNAVWLYMRYNGIPMPAAKKLVTEASNR

[1175] YEARFLELCDSFERNNPLYSEKLDKYLRGLAYQISGWVVGSLCCPGYHPEFRYAVNAGMEDLLTAQARGR

[1176] GGAVWGGEADQTQEEAQWIISLESIHTRSSTRYSDSDWQSVRSSSFSAIDVDHEDGEVRAVLLPAEQGLDT

[1177] KHVAAPFDYVAHLPSNGVRTTLIDALNLKCDLPSTTDAGIKEVVGKLITASLMFDDIELGSELRRGNPAAAA

[1178] VYGVPQTINAWSFAIVDAVSEAQDIPVTGCVDIVLEQLRDLQIGQSWDIRWQFHSSCPYEDEYLEMVANKT

[1179] GGLFKLISRTMTTGLPDITKSTIDDEVTQLGIYFQIGDDFKNLNEIEYASQKYFEEDLDEGKFSFNLVHYLTR

[1180] GQESPPFMLREIMQQRRESKGGNVVSKMLYLYMLECSGSLEYTHRRNKRLPVQINQIIGRLERITGKDNWVLRLCMGELTV*

[1181] >SEQ ID NO.72

[1182] ATGTGCACCATGGATGACCACACTTCCGAATTATTAGATATCTCTCAATTCGATACCCAGGGTTTTTGTCC

[1183] GGGTTACCCATTGAGAAGGCATAGATACGCAGGATTAGCCAACTCTGGTTGCTATGAGGCTAGACAAGA

[1184] CTGGATCCATTATGTTATTCCAGCTGAAGAGTTTGGTAGCTGCGATCCGACTAATGGTACTTTCACAGCT

[1185] TTAGTTTTGTGGTTGACCAAGCCAGAAAGATTACATCTGGTAAAGTGCATCATCGAATGTCTGTTCATTC

[1186] GTGGATTATATCCCTATGCTTTCTTACATGATAACGTCGTAGAAGCCGTGATGCCAGATATTATTACAAAC

[1187] AATGGAGACTGGTTTCACCTGAAAGAAGCGGAATTTAGGCAAAGGAATGTGCGTGAGGGAAGGAAGC

[1188] AAACTGATAACAAAATGATGTATCAAGACGCACGTTCTGACGCCAGGGATGCAGAAAGGGTCAAAAG

[1189] AGTGTGGAAGACGATGCTTTCTACAACGCTTAAACACAAGAGTTTTTCTTTCGCCAGCCTAGAAGAGT

[1190] ACTTGAATTACCGTATCATTGATACTGGTGGATATTGGGTTGAGTCCGTTTGGTTATTCGGCATGGGAAT

[1191] GACTTTGACTGAAGAAGAAGACGCCCAACTAGCCGAGACTCAACGTCCTTGCTACGCTTCCCTAGCTT

[1192] TGGCTATCGATTATTTTTCCTTTGATAGAGAATGGGAAGAGGCTCAAAACGGTGGTCCACCACCGCCAA

[1193] ACGCTGTTTGGCTATATATGAGATATAATGGTATACCTATGCCAGCTGCAAAAAAATTGGTGACGGAGGC

[1194] TTCTAATAGGTATGAGGCAAGGTTCCTAGAGCTTTGTGATTCTTTTGAACGTAATAACCCGTTATACAGC

[1195] GAAAAGTTGGACAAGTATCTGAGAGGCCTTGCATACCAGATTTCTGGTTGGGTAGTGGGTTCATTGTGT

[1196] TGCCCCGGTTATCACCCTGAGTTTAGGTATGCTGTTAACGCTGGAATGGAAGACTTGTTAACTGCTCAG

[1197] GCGAGAGGTAGAGGAGGCGCTGTCTGGGGTGGAGAGGCAGATCAAACACAAGAAGAAGCCCAGTGG

[1198] ATCATATCTCTAGAATCAATTCACACCAGAAGTTCAACTCGTTACTCTGACAGTGACTGGCAGAGCGTT

[1199] AGGTCAAGTTCATTCTCTGCAATCGATGTGGATCATGAGGATGGTGAAGTCAGAGCGGTATTGTTACCC

[1200] GCCGAACAAGGACTAGACACAAAGCATGTAGCTGCCCCTTTTGACTATGTGGCTCATCTTCCATCTAAC

[1201] GGGGTTAGAACAACGTTAATCGATGCACTAAATTTAAAGTGTGATTTACCGTCTACAACCGATGCTGGT

[1202] ATCAAGGAAGTGGTGGGTAAGTTAATAACTGCCTCTCTGATGTTCGATGATATCGAGCTGGGCAGCGAA

[1203] TTACGTCGTGGTAACCCTGCCGCCGCCGCAGTTTATGGTGTTCCCCAAACTATTAATGCTTGGTCATTCG

[1204] CCATAGTTGACGCTGTTAGCGAAGCTCAAGATATACCGGTCACTGGTTGTGTAGACATTGTTCTGGAGC

[1205] AACTTAGGGATTTGCAGATAGGACAATCCTGGGACATAAGATGGCAATTCCACTCATCATGTCCTTATGA

[1206] AGATGAATACTTGGAGATGGTTGCTAACAAGACTGGGGGATTATTTAAACTGATTTCAAGAACAATGAC

[1207] AACTGGCCTTCCCGATATCACTAAGAGTACTATCGACGATGAAGTTACTCAGCTTGGTATATACTTCCAG

[1208] ATCGGAGATGACTTTAAAAACTTAAATGAAATTGAGTATGCATCCCAAAAATACTTTGAAGAAGATCTA

[1209] GACGAAGGCAAATTTAGTTTTAATCTTGTCCACTACTTGACTAGGGGGCAAGAAAGTCCTCCTTTTATG

[1210] TTAAGAGAGATAATGCAGCAGCGTAGAGAATCCAAGGGAGGTAATGTCGTCAGTAAAATGCTTTATTTA

[1211] TATATGCTTGAATGTAGCGGTAGCTTAGAATACACACATAGGAGAAACAAGAGATTACCTGTCCAAATT

[1212] AATCAAATCATTGGAAGGCTTGAGAGAATTACAGGTAAGGATAACTGGGTCTTAAGATTATGTATGGGA

[1213] GAACTTACCGTC

[1214] >SEQ ID NO.73

[1215] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRSESLANMNCYEARQDWIHYHWPAMEFGSCDVTNGNAT

[1216] ALVLPWLSPERLHLVAAWIEREFIRRLYPYNFCHNNVVEAVMPDSSTNNLDDFFLPEAEKRQDNVRMGRK

[1217] VIQAKMMYQTACKSKRCAETYKRVWKTMMSTCLKHKSYSFKSLRSYSNYRIIDTGGYWVESCMLFGMN

[1218] MTLTEEEDAQQAEVMRPCYASLTDWNDYFSFDREWEEAANGGPPPTNAVWLYMRWNGIPMPAAKLLVG

[1219] EAVYQYEARFLELCDSRRRNNPLYSEKLDQQLRGKAYQDSGSVVWSLTCPRYHPWFRYDPNAKMEDLFT

[1220] AQARGDGGAVSGGEADYTAEERQSKISLESQKTFSSTRYSTSDQQSSRSMSFSEISGDGEDGQTHAVKLRA

[1221] EQFLDTKHSAAPFDRVASLPSKGVRTTLIDALGLWCPLPDTMLAGIKEVVDKLHTASLMFLDIEDGSELCRL

[1222] NPAAHAVYGVPQTINAAFFAIVDAVSKAQDIPVVGLVDIVLEVLRDLHIGQSVDISDTRHSSMPLETEYQVL

[1223] VAKKTGGLFKLISNLMTTGLPDITKSTICDLVTQLGIYFQIDDDFKNLNSDEYASKKGFCEDLDEGKFSFPLV

[1224] HYLTTGQHSNPFMYREIMQQRRESKGLEVESTMLADQYLKKSGCLEYTHYTPKREEDQINQIIGRLERITGKDNWVLRLCMGELTV*

[1225] >SEQ ID NO.74

[1226] ATGTGCACCATGGACGACCACACTTCTGAATTGCTTGACATCTCTCAGTTTGATACTCAAGGTTTTTGTC

[1227] CGGGCTATCCATTACGTAGACATAGATCAGAGAGTTTGGCTAATATGAATTGCTACGAAGCCAGGCAAG

[1228] ACTGGATTCATTATCACTGGCCAGCTATGGAATTTGGTAGTTGTGATGTTACGAACGGAAACGCAACCG

[1229] CTTTAGTACTACCATGGCTGAGTCCAGAGCGTTTACATTTGGTCGCTGCTTGGATCGAGAGAGAGTTTA

[1230] TTAGGAGATTGTATCCTTACAATTTTTGCCACAATAATGTGGTCGAAGCAGTTATGCCAGACTCTTCCAC

[1231] TAATAACCTTGATGATTTCTTTTTGCCCGAAGCAGAAAAAAGGCAGGACAATGTCAGAATGGGAAGAA

[1232] AGGTAATTCAAGCGAAAATGATGTATCAAACAGCCTGTAAATCCAAAAGATGTGCTGAGACCTATAAAC

[1233] GTGTTTGGAAGACTATGATGAGTACCTGCTTAAAACATAAATCATACTCTTTTAAGTCATTGCGTAGTTA

[1234] CTCAAACTATCGTATCATAGACACAGGTGGTTATTGGGTAGAGTCATGCATGCTGTTTGGTATGAACATG

[1235] ACACTGACTGAAGAAGAAGACGCACAGCAAGCCGAGGTGATGAGACCTTGTTATGCATCCCTTACAGA

[1236] TTGGAACGATTACTTCTCTTTCGATAGAGAGTGGGAAGAAGCCGCGAATGGCGGACCACCTCCCACCA

[1237] ACGCTGTGTGGTTGTATATGAGATGGAACGGTATTCCCATGCCAGCAGCGAAATTGTTAGTGGGAGAAG

[1238] CCGTTTATCAATATGAAGCAAGGTTCTTAGAATTATGTGATAGTAGACGTAGAAACAATCCATTATACTCT

[1239] GAAAAACTGGATCAACAACTAAGAGGTAAAGCTTACCAAGACTCAGGATCTGTGGTATGGAGTCTTAC

[1240] CTGCCCACGTTATCATCCGTGGTTCAGATATGACCCAAATGCTAAAATGGAAGATTTATTTACCGCACAA

[1241] GCTAGAGGGGATGGAGGAGCTGTATCCGGCGGTGAGGCAGATTACACTGCTGAGGAAAGACAATCTAA

[1242] GATTTCCTTGGAAAGTCAGAAAACTTTTTCATCAACAAGGTATTCTACCTCCGATCAACAATCCTCAAG

[1243] ATCTATGTCCTTCTCTGAAATCAGTGGTGATGGGGAGGATGGTCAAACACATGCAGTAAAACTTCGTGC

[1244] AGAACAGTTCTTAGATACTAAGCACTCTGCTGCACCGTTTGATCGTGTAGCGTCCCTGCCCAGTAAAGG

[1245] TGTTAGAACTACTTTAATCGACGCTCTAGGTTTATGGTGTCCTTTACCAGACACCATGTTAGCTGGCATT

[1246] AAGGAAGTTGTTGATAAACTTCATACAGCATCACTGATGTTTCTAGACATAGAAGACGGCTCTGAGTTA

[1247] TGTAGGCTAAATCCCGCAGCGCATGCTGTATATGGTGTTCCTCAAACTATTAATGCTGCTTTCTTCGCAAT

[1248] TGTCGATGCCGTTTCAAAAGCACAAGATATTCCAGTAGTTGGCCTAGTAGATATTGTTTTAGAGGTCTTG

[1249] AGAGATCTACACATAGGGCAATCAGTGGATATTTCAGACACTAGACACTCATCAATGCCACTAGAAACT

[1250] GAATATCAAGTCTTGGTGGCTAAGAAAACCGGTGGTTTGTTCAAATTGATTAGTAACTTAATGACCACC

[1251] GGCTTACCAGACATAACAAAGTCCACCATCTGTGACTTAGTGACTCAATTGGGAATCTACTTCCAGATC

[1252] GACGATGACTTTAAGAATTTAAATTCAGATGAATATGCGTCAAAAAAGGGTTTTTGTGAGGATTTGGAC

[1253] GAAGGTAAATTCAGCTTCCCACTTGTACACTACTTGACTACCGGCCAACACTCCAACCCATTCATGTAC

[1254] CGTGAATTATGCAACAACGTAGAGAATCAAAGGGTTTAGAAGTTGAATCAACTATGCTAGCGGATCAA

[1255] TACTTGAAAAAAAGTGGTTGCTTAGAGTATACCCACTACACTCCTAAGAGGGAGGAGGATCAAATCAA

[1256] TCAAATTATTGGCCGTCTTGAAAGGATTACTGGGAAGGACAACTGGGTGTTACGTTGTGCATGGGTGA

[1257] ATTGACAGTT

[1258] SEQ ID NO.75

[1259] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHPYESLANVGCYEARMDWKHYVGPFEYFSSCDGMNGNFT

[1260] ALVVGLTKMERLDLVHMVIEEEHINVLYPYAFLHDNVVEAVMGDSSTNNGGDFHLGEAENRERNVRDWR

[1261] YQIQAKMMYQLARTDKRCAERVKRVNKTMLSQTLKHKSDFFATPEEYCNYRIIYTGGYWVESVMLFGMG

[1262] MTLTEAEPAQVVEVVEPTYNSLALANDYFSFDREWELAQNGGYPPENAVWLYMCWNWIPMPVFHKLVPE

[1263] ASNRAEARPLEMCDSFVRNNPLYSEKLVKYLRGLAYQISGNNSWSLTCPFYHPEWRYDPAAGMEDLLTAQ

[1264] ARGDGGAVSGGEADYTAEGRKSIISLQSQHTASSTRYSASDWQWSRSSSGSEIAVDGEDGETHAVKLIAEQ

[1265] GLDTPHVAAKFDVVASLPEKGPRTTTIDALFLWCDLPDTHLAGIKEVVDKLHTCILRFVDIEPGSELRRHNP

[1266] AAHAIYCVPQTINADSFAIVDATSAAKDIPVTGYYDIVLESLRDKHIGDSYDIMWTRHSSTPSGTEYLAMVT

[1267] YKTGILFCLILRVMTTGLRMITMVTIDDLVTQLTIYFQCRDDFKNLNSDEYYSQEGFCEDNIEGKWSFPLTH

[1268] YLTKGQESPPFMLSEIMLQDREVKGLNVPSKMCILQQLKKFGSLEYTLRTLKYLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[1269] >SEQ ID NO.76

[1270] ATGTGCACCATGGATGATCATACTTCCGAATTACTAGACATCAGCCAGTTTGATACACAAGGTTTTTGTC

[1271] CAGGATATCCTTTAAGAAGACATCCCTATGAAAGTCTAGCTAACGTCGGATGCTATGAAGCGCGTATGG

[1272] ATTGGAAGCATTACGTAGGACCCTTTGAATATTTCTCTTCTTGCGACGGAATGAATGGTAATTTCACTGC

[1273] ACTTGTTGTGGGCCTTACTAAAATGGAAAGGCTGGACTTGGTGCACATGGTGATAGAAGAGGAACATA

[1274] TTAACGTCCTATATCCATACGCTTTTTTACATGATAATGTCGTAGAAGCTGTGATGGGCGATTCAAGCACT

[1275] AATAATGGTGGCGATTTCCATTTGGGGGAAGCCGAAAATCGTGAGAGAAACGTCAGAGACTGGCGTTA

[1276] CCAAATTCAGGCCAAAATGATGTACCAATTAGCCAGAACGGACAAGAGATGCGCGGAGAGAGTTAAA

[1277] AGAGTGAACAAAACAATGTTGTCTCAGACTTTAAAGCACAAATCCGATTTTTTTGCCACTCCAGAGGA

[1278] ATATTGCAACTATCGTATAATCTATACGGGTGGCTACTGGGTGGAATCTGTCATGTTATTCGGTATGGGAA

[1279] TGACATTGACTGAGGCAGAACCAGCACAAGTCGTTGAAGTTGTTGAACCCACTTACAACAGCTTAGCC

[1280] TTGGCAAACGACTACTTTTCTTTCGACAGGGAGTGGGAATTGGCCCAGAATGGCGGATACCCACCAGA

[1281] AAATGCAGTGTGGTTATACATGTGTTGGAATTGGATTCCTATGCCAGTGTTTCACAAGTTGGTTCCAGA

[1282] GGCTTCTAACCGTGCCGAAGCTAGGCCTCTGGAAATGTGTGATAGCTTTGTACGTAATAACCCCCTTTA

[1283] CAGCGAGAAATTAGTTAAGTACTTGAGAGGTTTAGCCTATCAAATTAGTGGCAACAATTCATGGTCCTT

[1284] GACTTGCCCGTTTTATCACCCAGAATGGAGGTATGACCCAGCTGCAGGTATGGAAGATTTATTGACTGC

[1285] GCAAGCTAGAGGCGATGGTGGTGCAGTGTCTGGTGGTGAGGCTGATTATACCGCTGAGGGCAGAAAAT

[1286] CTATCATTTCACTTCAATCTCAACATACGGCCTCTAGTACAAGATACTCTGCTTCAGATTGGCAATGGAG

[1287] TAGGTCAAGCTCAGGATCAGAAATAGCTGTTGATGGTGAAGATGGAGAAACTCATGCAGTCAAATTGA

[1288] TCGCCGAGCAAGGATTAGATACACCGCACGTTGCCGCTAAGTTTGACGTTGTGGCGTCTCTTCCAGAA

[1289] AAAGGTCCTAGAACAACAACCATCGATGCACTTTTCCTATGGTGTGATTTACCCGACACACATCTAGCC

[1290] GGTATAAAGGAGGTTGTCGATAAGTTGCATACCTGCATTTTGAGATTCGTGGACATTGAACCAGGCTCA

[1291] GAACTAAGAAGGCACAATCCCGCAGCACATGCAATTTACTGTGTTCCACAAACCATTAACGCAGATAGT

[1292] TTTGCCATCGTAGACGCAACTTCAGCTGCAAAGGACATTCCAGTGACCGGTTATTATGACATTGTTTTAG

[1293] AATCCCTTAGAGATAAGCATATTGGCGATTCTTATGATATTATGTGGACAAGACATTCAAGTACTCCAAG

[1294] TGGAACAGAGTATTTGGCGATGGTGACTTATAAGACTGGTATTCTGTTTTGCTTGATATTAAGAGTGATG

[1295] ACGACGGGCCTTCGTATGATTACAATGGTTACTATCGACGACCTAGTAACCCAATTAACTATATATTTTCA

[1296] GTGCAGAGATGATTTCAAGAACCTAAACAGTGATGAATACTACAGTCAAGAAGGTTTTTGCGAAGATA

[1297] ACATCGAAGGTAAGTGGTCATTTCCACTGACCCATTATCTTACCAAAGGTCAAGAGTCTCCCTCCCTTCA

[1298] TGTTATCAGAGATAATGCTGCAAGATAGGGAAGTTAAGGGTCTTAATGTACCCTCCAAGATGTGCATTTT

[1299] ACAACAATTGAAAAAATTTGGATCATTGGAATACACACTGAGGACTTTAAAATATTTGGAAGTTCAAAT

[1300] TAACCAAATAATTGGTAGGCTAGAAAGAATTACCGGGAAGGACAATTGGGTTTTGCGTCTTTGCATGGG

[1301] AGAACTAACAGTT

[1302] SEQ ID NO.77

[1303] MCTMDDHTSELLDISQFDTQGFCPGYPLRRHRYESLANSGCYEARQSWSHYHGPAEEWGSCYPTRCQFTH

[1304] LELPLTKERRLHLVTYIIECLFIRMLYDYGFLHDNVVEAVMHDSSTNNAFTFHLGEAEKRQRCVRMWRHQ

[1305] YNAKMMYQYANHDKRMFKQVYCVVCIMLATTLKHKSESFASLEEYLNYRIGDCGGYWFTSVMLFGMG

[1306] MTLTEEEYWQLAEVVRPCNASLALANDYFSFDREWEEAQNGGPPPTNAICEYWRWNGIATSAGKKLMRE

[1307] ASQLYEARFAELYDSFRRNNPLYSEKLDKYERGYKYQIIGNVVWSLTRPNYHPEFRYLPNASHADSLTAQA

[1308] RGFGGAVCGGEADYGAEHLVSIISLESVHTAMSTRYSASWWQSSRSHSFSEISVAGFDGETHRVKLCACWG

[1309] LDTEHVAAPFDYVAHLPSKSVRTTLILALNLWCDGPDTYQAGVKEVTDKLHTNSQMFDDIEDGSEQRRGN

[1310] WAAHIVIGVPQTIPSASFAAVAAVCKAEDVIVDAAVDIVLEQLRDLHTSQQYQIPWTRHSSCPKEWEYLEM

[1311] VARKTGGLFKLISRLMTTGAPAITKSTMDDLVTGLEIYQQIRDDFKNLNSDEYASQKGFCEDLDEGKFSFRL

[1312] VHHLTAGQWFPPFMLRENMQQRRESKGLNVPSKMDAIQQLKKWGSLHKTHRTLKRLEVQINQIIGRLERITGKDNWVLRLCMGELTV*

[1313] >SEQ ID NO.78

[1314] ATGTGTACCATGGATGATCATACTTCTGAACTTCTTGATATTTCCCAATTCGACACGCAGGGTTTCTGCC

[1315] CTGGTTATCCATTAAGGAGACATAGATATGAATCCCTAGCTAACAGCGGCTGTTATGAAGCCAGGCAGA

[1316] GTTGGTCACATTACCACGGTCCTGCTGAAGAATGGGGTTCCTGTTATCCCACAAGATGCCAATTTACTC

[1317] ATTTGGAACTTCCTTTAACCAAAGAAAGGAGGTTGCATCTTGTAACATATATCATTGAATGTCTATTTATT

[1318] CGTATGTTGTATGATTATGGCTTCCTACATGACAACGTAGTTGAGGCAGTTATGCATGATTCTAGTACCAA

[1319] TAACGCTTTTACATTTCACTTGGGCGAGGCTGAAAAGAGACAAAGATGTGTTAGGATGTGGCGTCATC

[1320] AATACAATGCCAAGATGATGTACCAATACGCCAATCATGACAAAAGGATGTTCAAGCAAGTGTACTGCG

[1321] TCGTTTGTATTATGTTAGCCACAACCTTGAAACACAAGAGCGAATCTTTTGCTTCACTTGAAGAATATCT

[1322] GAACTATAGAATTGGTGATTGCGGAGGGTACTGGTTTACATCTGTGATGCTTTTCGGTATGGGCATGACG

[1323] TTAACCGAAGAAGAGTACTGGCAACTAGCAGAAGTAGTAAGACCTTGTAACGCATCTCTAGCCTTGGC

[1324] TAATGATTACTTCAGTTTTGATCGTGAGTGGGAGGAAGCGCAAAATGGCGGACCACCTCCTACTAATGC

[1325] AATATGTGAATATTGGAGATGGAACGGTATTGCAACATCTGCTGGTAAAAAATTAATGAGAGAGGCATC

[1326] TCAACTATATGAAGCTAGGTTTGCAGAACTATACGATAGTTTTAGGAGAAACAACCCCTTGTACTCTGA

[1327] GAAGTTAGATAAGTACGAGAGAGGTTACAAGTATCAGATAATCGGTAATGTAGTCTGGAGTCTAACACG

[1328] TCCTAATTACCACCCAGAATTCAGATACTTACCAAATGCCTCACATGCTGACAGCTTAACTGCCCAAGCT

[1329] AGAGGTTTTGGAGGAGCTGTTTGCGGTGGGGAAGCGGACTATGGTGCTGAACATTTAGTGTCAATTATA

[1330] AGTCTTGAGAGCGTTCATACTGCCATGAGCACTAGGTATTCTGCTTCTTGGTGGCAATCCAGCCGTAGT

[1331] CATTCATTTTCTGAAATTTCAGTGGCAGGATTTGATGGTGAGACTCATAGAGTCAAATTGTGTGCTTGTT

[1332] GGGGTTTAGACACTGAGCATGTGGCAGCACCATTCGATTACGTTGCGCACTTACCATCTAAGTCTGTTA

[1333] GAACCACACTAATCTTGGCTCTGAACTTGTGGTGTGATGGCCCGGATACTTATCAAGCTGGTGTTAAGG

[1334] AAGTTACAGATAAATTGCACACCAATAGTCAGATGTTTGATGATATTGAGGATGGATCCGAGCAAAGAA

[1335] GAGGTAACTGGGCTGCTCACATAGTAATAGGTGTTCCACAAACGATTCCCTCCGCTTCTTTTGCGGCTG

[1336] TTGCGGCCGTATGCAAAGCAGAAGACGTAATCGTTGACGCTGCGGTCGATATAGTGCTGGAACAGTTA

[1337] AGAGATCTGCATACAAGCCAACAATATCAGATACCATGGACTAGACATAGTTCTTGTCCGAAGGAGTGG

[1338] GAGTATCTTGAGATGGTAGCTCGTAAGACAGGTGGATTATTTAAATTAATATCTAGATTGATGACCACCG

[1339] GAGCTCCAGCAATTACAAAATCCACAATGGATGATCTGGTGACCGGGTTGGAGATATACCAGCAAATAA

[1340] GGGATGATTTCAAAAACTTGAATTCTGATGAGTATGCTAGCCAAAAAGGTTTTTGCGAAGATTTAGACG

[1341] AAGGTAAGTTCTCCTTTCGTTTGGTTCATCATTTGACTGCTGGTCAATGGTTTCCCCCTTTTATGCTTAG

[1342] GGAAAATATGCAACAAAGAAGAGAATCAAAGGGCTTGAATGTACCTTCTAAAATGGATGCTATTCAAC

[1343] AATTGAAGAAATGGGGCTCTTTGCATAAAACTCATAGGACTTTAAAGCGTCTGGAAGTTCAAATTAATC

[1344] AAATAATAGGTCGTTTGGAGAGAATCACTGGCAAGGATAACTGGGTTTTAAGATTGTGTATGGGTGAAT

[1345] TGACAGTC

[1346] The above embodiments are preferred embodiments of the present invention, but the embodiments of the present invention are not limited to the above embodiments. Any changes, modifications, substitutions, combinations, or simplifications made without departing from the spirit and principle of the present invention shall be considered equivalent substitutions and shall be included within the protection scope of the present invention.

Claims

1. A geraniol synthase mutant derived from *Thielavia arenaria*, characterized in that, The amino acid sequence of the geraniol synthase is selected from either (a) or (b) below: (a) An amino acid sequence derived from the sequence shown in SEQ ID No:1 by substitution, deletion or addition of at least one amino acid; (b) has an amino acid sequence that is at least 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to (a).

2. The geraniol synthase mutant according to claim 1, characterized in that, The amino acid sequence of the geraniol synthase mutant is the amino acid sequence derived from the sequence shown in SEQ ID No:1 by substituting at least one amino acid residue in amino acid residues from position 60 to 715. Preferably, the number of amino acid residues substituted is 1, 2, 3, 4, 5, 6, 7, 8, or 9; More preferably, the substituted sites include at least one of the following positions: 60, 88, 173, 174, 188, 195, 196, 197, 228, 243, 245, 252, 431, 441, 475, 571, 604, 605, or 715 of SEQ ID No:

1.

3. The geraniol synthase mutant according to claim 2, characterized in that, The amino acid sequence of the geranylgeraniol synthase mutant contains at least one conserved substitution and at least one non-conserved substitution among the amino acid residues. Preferably, the amino acid residue substitutions include at least one of S60G, I88L, K173R, H174D, Y188F, G195A, Y196P, W197F, S228A, E243A, A245F, P252L, V431I, T441D, F475L, I571L, F604Y, K605Q, and E715K, and / or the amino acid sequence of the geraniol synthase mutant is the sequence shown in SEQ ID No: 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 41, 45, 49, 51, 55, 57, or 61; More preferably, the amino acid sequence of the geraniol synthase mutant is the sequence shown in SEQ ID No: 35, 37, 39, 43, 47, 53 or 59.

4. A nucleic acid molecule encoding a geraniol synthase mutant according to any one of claims 1-3.

5. A recombinant vector containing the nucleic acid molecule according to claim 4.

6. A recombinant cell containing the nucleic acid molecule according to claim 4 or the recombinant vector according to claim 5; wherein the host cell of the recombinant cell is bacteria or fungi.

7. A highly efficient geraniol-synthesizing strain, characterized in that, The strain is a mutant of geraniol synthase according to any one of claims 1-3, which is integrated into the genome of Saccharomyces cerevisiae.

8. A method for preparing geraniol, characterized in that, The preparation method includes culturing the recombinant cells according to claim 6 or fermenting the geraniol-producing strain according to claim 7 to isolate and obtain geraniol.

9. A method for preparing α-tocotrienol, characterized in that, The α-tocotrienol was prepared using geraniol, which was prepared according to the method described in claim 8, as a raw material. Preferably, the preparation method includes: (1) Geraniol is prepared by the method according to claim 8 and then reacted with trimethylhydroquinone in a first contact reaction to obtain the chain product after Friedel-Crafts reaction; (2) The chain product and an aqueous solution of sodium dithionite are subjected to a second contact reaction to obtain the reduced phenol; (3) The reduced phenol was cyclized under the catalysis of Lewis acid to obtain α-tocotrienol.

10. The geraniol synthase mutant according to any one of claims 1-3, The application of the nucleic acid molecule according to claim 4, the recombinant vector according to claim 5, the recombinant cell according to claim 6, the geraniol-producing strain according to claim 7, and the preparation method according to claim 8 or 9 in the fermentation production of α-tocotrienol.

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