Nipah virus f protein monoclonal antibody and application thereof

By preparing and screening monoclonal antibodies 2D12 and 3B10 that efficiently bind to the Nipah virus F protein, the challenges of virus infection control and detection in existing technologies have been solved, achieving efficient virus neutralization and detection effects, and supporting epidemiological surveillance and diagnosis.

CN121426941BActive Publication Date: 2026-06-09SHANGHAI VETERINARY RESEARCH INSTITUTE CAAS (CHINESE ANIMAL HEALTH & EPIDEMIOLOGY CENTER SHANGHAI BRANCH)
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-12-04
Publication Date
2026-06-09

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Abstract

This invention discloses a Nipah virus F protein monoclonal antibody and its applications. The antibody comprises antibody 2D12 and antibody 3B10, and is prepared from a Nipah virus F protein immunogen. This invention utilizes a specific anti-Nipah virus F protein monoclonal antibody pair for detection. This antibody pair specifically binds to the Nipah virus F protein, exhibiting high titer, good affinity, and neutralizing activity. Furthermore, the detection kit prepared based on this antibody pair can effectively detect Nipah virus, providing technical support for the treatment, epidemiological monitoring, and diagnosis of Nipah virus infection.
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Citation Information

Patent Citations

  • Soluble Forms of Hendra and Nipah Virus F Glycoprotein and Uses Thereof

    AU2013276968A1

  • Specific monoclonal antibody for resisting Nipah virus Post-F protein

    CN119798424A