A cooling device and method for producing a pharmaceutical intermediate

Abstract

The application relates to the field of cooling equipment, in particular to a cooling device and method for medical intermediate production, which comprises a cooling bin, the inside of the cooling bin is internally provided with uniformly distributed partitions, the inside of the cooling bin is divided into multiple cooling cavities through the partitions, a rack is arranged at the lower part of the cooling bin, uniformly distributed chain plates are arranged at the upper part of the rack, fixed shafts are fixedly connected to the middle parts of the two ends of the chain plates, the fixed shafts are connected through soft chains, the chain plates are formed with circulating conveying belts, the circulating conveying belts are used for conveying storage tanks, uniformly distributed horizontal pipes are fixedly connected to the top of the cooling bin, the horizontal pipes are connected through through pipes, and sliding seats are fixedly connected to the ends, away from the horizontal pipes, of the through pipes. The application avoids cold air waste when there is no material, significantly reduces refrigeration energy consumption, and solves the core pain points of high operation cost and low energy utilization rate of traditional equipment.

Description

Technical Field

[0001] This invention relates to the field of cooling equipment, and more particularly to a cooling apparatus and method for the production of pharmaceutical intermediates. Background Technology

[0002] In the production of pharmaceutical intermediates, the cooling process is a critical step to ensure product stability and prevent deterioration, directly affecting the quality of subsequent storage and processing. Existing cooling equipment generally suffers from several technical drawbacks: most use a single, open cooling chamber, which easily triggers violent airflow exchange when storage tanks enter and exit, leading to large temperature fluctuations within the chamber, poor cooling uniformity, and a tendency for localized abnormal crystallization or deterioration of intermediates; the cold air is often continuously and indiscriminately output, maintaining a cooling state even when there is no material, resulting in significant energy consumption and high operating costs; some equipment has unreasonable airflow jet direction, with airflow collisions on both sides causing a decrease in flow velocity and creating cooling dead zones, and the fixed storage tanks further exacerbate the problem of uneven cooling; at the same time, traditional equipment has poor adaptability, making it difficult to flexibly adjust according to storage tank specifications and cooling requirements, resulting in low cooling efficiency and long cooling times, failing to meet the needs of large-scale production. These problems not only affect the product quality of pharmaceutical intermediates but also restrict production efficiency and increase energy costs. Therefore, we propose a cooling device and method for pharmaceutical intermediate production to solve the aforementioned problems. Summary of the Invention

[0003] The purpose of this invention is to address the shortcomings of the prior art by providing a cooling device and method for the production of pharmaceutical intermediates.

[0004] To achieve the above objectives, the technical solution adopted by the present invention is as follows: a cooling device for the production of pharmaceutical intermediates, comprising a cooling chamber, wherein uniformly distributed partitions are installed inside the cooling chamber, and the cooling chamber is divided into multiple cooling chambers by the partitions; a frame is installed in the lower part of the cooling chamber, and uniformly distributed chain plates are installed in the upper part of the frame; fixed shafts are fixedly connected to the middle of both ends of each chain plate, and adjacent fixed shafts are connected by flexible chains; each chain plate forms a circulating conveyor belt for conveying storage tanks; uniformly distributed horizontal pipes are fixedly connected to the top of the cooling chamber, and the horizontal pipes are connected to each other by through pipes; the end of each through pipe away from the horizontal pipe is fixedly connected to a... The slide block has nozzles fixedly connected to the side of the slide block near the chain plate. An air outlet plate is fixedly connected to the side of the pipe near the storage tank. Each air outlet plate has an inclined airflow channel that communicates with the inside of the pipe. An air outlet is opened at the end of each airflow channel, located on the side of the air outlet plate near the storage tank. A sealing plate is slidably connected to the middle of each air outlet plate, with an opening on one side and a toothed groove on the bottom side. A crossbar is rotatably connected to the bottom of each air outlet plate near the storage tank, with a half-gear fixedly connected to the end of each crossbar. The half-gear meshes with the toothed groove. A torsion spring for resetting is installed between the crossbar and the air outlet plate.

[0005] Preferably, fixed compartments are installed on the upper middle part of both sides of the frame, and rotating shafts are provided on the upper and lower parts of both sides of the circulating conveyor belt. Drive wheels are fixedly connected to both sides of the outer periphery of the rotating shafts. The drive wheels are used to drive the circulating conveyor belt. A reduction motor is installed at the end of one of the rotating shafts. The reduction motors are installed inside the fixed compartments. A bottom compartment is provided on the upper inner side of the circulating conveyor belt. The bottom compartment is fixedly connected to the upper inner side of the frame.

[0006] Preferably, each of the chain plates has a bayonet in the middle, which is used to connect to the mounting base. Each mounting base has a rotating seat on its top. Each mounting base has a fixed plate rotatably connected to its upper side via the rotating seat. Each fixed plate has uniformly distributed guide vanes fixedly connected to its outer periphery. Each fixed plate has a storage tank at the top center.

[0007] Preferably, the slides are slidably connected to both sides of the top of the frame, and each slide has a mounting rod running through its center. The mounting rods are installed on both sides of the top of the frame.

[0008] Preferably, each of the fixed plates is equipped with evenly distributed electric push rods, which are used to fix the bottom of the storage tank.

[0009] Preferably, each of the mounting bases has a mounting post fixedly connected to its bottom center, and the mounting posts are engaged inside the bayonet opening.

[0010] Preferably, the top of the cooling chamber is equipped with a top compartment, and the top compartment is equipped with a compressor refrigeration assembly and a refrigeration unit exhaust pump. The outlet of the refrigeration unit exhaust pump is connected to the inside of the horizontal pipe.

[0011] Preferably, a reserved opening is provided in the middle of both sides of the cooling cavity, and a uniformly distributed partition plate is fixedly connected to the top of each reserved opening.

[0012] Preferably, a control panel is installed on one side of the front of the cooling chamber, and the control panel is used for the other drive devices.

[0013] Preferably, a cooling method for the production of pharmaceutical intermediates includes the following cooling steps:

[0014] S1. Preparations before operation

[0015] S1.1. Start the equipment self-test through the control panel at the front of the cooling chamber to confirm that the drive equipment is running normally, and confirm that the refrigeration system pipeline in the top chamber is sealed and there is no cold air leakage; the nozzles and air outlets are not blocked. According to the cooling requirements of the pharmaceutical intermediates, set the cooling temperature and the running speed of the circulating conveyor belt through the control panel.

[0016] S1.2. Based on the size of the storage tank, select the matching mounting base and fixing plate, and determine the installation spacing of the mounting base on the chain plate according to the cooling rate requirements.

[0017] S2. Loading and securing

[0018] S2.1. Engage the mounting post at the bottom of the mounting base into the slot in the middle of the chain plate to ensure a secure and loose installation.

[0019] S2.2 Place the storage tank containing the pharmaceutical intermediate in the inner area of ​​the top center of the fixed plate;

[0020] S2.3 After the sensor on the inner side of the top of the fixed plate senses the storage tank, it automatically starts the electric push rods that are evenly distributed on the inner side. The electric push rods extend and retract to clamp the bottom of the storage tank, ensuring that the storage tank is stable and does not shake.

[0021] S3, Start the cooling system

[0022] S3.1. Start the geared motor inside the fixed compartment through the control panel. The motor drives the rotating shaft to rotate. The drive wheel on the rotating shaft drives the circulating conveyor belt to rotate in a circular manner through the fixed shaft, gradually guiding the mounting base containing the storage tank into the cooling compartment.

[0023] S3.2. Simultaneously start the compressor refrigeration components and refrigeration unit exhaust pump in the top compartment. The refrigeration components cool the extracted air, and the refrigeration unit exhaust pump guides the cold air into the horizontal pipe, and then distributes it to the corresponding slide and exhaust plate of each cooling chamber through the pipe.

[0024] S4, Cooling Process Monitoring

[0025] S4.1 When the circulating conveyor belt moves the storage tank to a certain cooling chamber, the storage tank will press against the crossbar at the bottom of the air outlet plate in that area, causing the crossbar to deflect. Through the meshing transmission of the half gear and the tooth groove, the sealing plate is pushed to move, so that the opening on the sealing plate is aligned with the airflow channel inside the air outlet plate, and cold air is sprayed out from the air outlet to cool the storage tank.

[0026] S4.2 After the storage tank continues to move and detaches from the crossbar, the torsion spring drives the crossbar to reset, the sealing plate resets simultaneously, the airflow channel is cut off, and the cold air output is stopped, realizing "gas out when the tank arrives, gas stops when the tank moves".

[0027] S4.3 When the storage tank moves between the nozzles, the cold air ejected from the nozzles impacts the guide vanes on the outer periphery of the fixed plate, causing the fixed plate to rotate around the mounting base via the rotating seat, so that the storage tank is evenly contacted by the cold airflow, thereby improving the cooling efficiency.

[0028] S4.4 The circulating conveyor belt drives the storage tank through multiple cooling chambers in the cooling compartment in sequence. The partitions prevent airflow exchange between the chambers, ensuring stable cold air in each chamber and achieving continuous gradient cooling.

[0029] S5. Discharge and Subsequent Operations

[0030] S5.1 After the storage tank completes the cooling process of all cooling chambers, it is transported to the discharge end of the cooling chamber by a circulating conveyor belt, and the storage tank is removed manually or by a robotic arm.

[0031] S5.2 After all storage tanks have discharged, shut down the refrigeration system and transmission mechanism in sequence through the control panel. After the equipment has completely stopped, clean the debris in the cooling chamber, check whether there are any impurities remaining in the nozzles and air outlets, and clear any blockages if necessary.

[0032] Compared with the prior art, the present invention has the following beneficial effects:

[0033] 1. Addressing the problem that existing equipment cooling chambers are open or single-cavity, resulting in intense airflow exchange and large internal temperature fluctuations when the storage tank is in and out, thus affecting the cooling effect, this invention divides the interior of the cooling chamber into multiple independent cooling chambers through partitions. This effectively blocks airflow interference at the inlet and outlet ends, ensuring stable temperature in each chamber. At the same time, the smaller volume of the chambers facilitates rapid filling with cold air. The cold air generated by the top chamber compressor refrigeration components is precisely delivered to each chamber through horizontal pipes and through pipes, and evenly diffused through nozzles, significantly improving the cooling rate of the storage tank and the pharmaceutical intermediates inside. This solves the pain points of long cooling time and uneven temperature distribution in traditional equipment, and is more suitable for the cooling stability requirements of intermediates.

[0034] 2. Addressing the problem that existing cooling equipment often employs a fixed airflow jet method, which easily leads to airflow collisions and reduced flow velocity on both sides, resulting in uneven cooling of the storage tank (slow cooling in some areas and over-cooling in others), this invention designs an air outlet plate with staggered pipes and inclined airflow channels. This ensures that the cold airflow from the air outlets on both sides does not interfere with each other and flows smoothly around the storage tank. Simultaneously, the airflow directly acts on the entire storage tank, avoiding cooling dead zones caused by dispersed airflow in traditional equipment. This ensures uniform cooling of the intermediate, effectively reducing problems such as abnormal crystallization and deterioration of the intermediate caused by localized temperature differences, and improving cooling quality.

[0035] 3. Addressing the issue of existing equipment continuously outputting cold air regardless of the presence of storage tanks, resulting in ineffective cold air loss and excessive energy consumption, this invention achieves automatic regulation of "cold air output when storage tanks are present, cold air stop when storage tanks leave" through a linkage structure of a crossbar, half gear, sealing plate, and torsion spring. When the storage tank triggers the crossbar, the sealing plate opens, allowing for precise cold air injection; after the storage tank leaves, the sealing plate automatically closes, blocking the airflow channel and preventing cold air waste when there is no material, significantly reducing refrigeration energy consumption and solving the core pain points of high operating costs and low energy utilization of traditional equipment.

[0036] 4. Addressing the issues of low efficiency and inadequate localized cooling caused by the fixed storage tanks in existing equipment that rely solely on natural airflow for cooling, this invention incorporates guide vanes around the fixed plate. When the cold air ejected from the nozzle impacts the guide vanes, it causes the fixed plate and the upper storage tank to rotate synchronously, ensuring 360° contact between the storage tank and the cold airflow. Compared to traditional static cooling methods, this significantly improves heat exchange efficiency. Furthermore, the cooling effect can be further optimized by adjusting the speed of the circulating conveyor belt to suit different cooling needs, solving the problems of low cooling efficiency and poor adaptability in traditional equipment and contributing to improved overall production efficiency. Attached Figure Description

[0037] Figure 1 This is a three-dimensional structural schematic diagram of a cooling device and method for producing pharmaceutical intermediates according to the present invention.

[0038] Figure 2 This is a schematic diagram of the internal structure of the cooling chamber of a cooling device and method for producing pharmaceutical intermediates according to the present invention.

[0039] Figure 3 This is a schematic diagram of the internal structure of the frame of a cooling device and method for producing pharmaceutical intermediates according to the present invention;

[0040] Figure 4 This is a partial structural diagram of the fixed plate of a cooling device and method for producing pharmaceutical intermediates according to the present invention;

[0041] Figure 5This is a partial structural diagram of the drive wheel of a cooling device and method for producing pharmaceutical intermediates according to the present invention;

[0042] Figure 6 This is a partial structural diagram of the crossbar of a cooling device and method for producing pharmaceutical intermediates according to the present invention.

[0043] Figure 7 This is a partial structural diagram of the half-gear of a cooling device and method for producing pharmaceutical intermediates according to the present invention.

[0044] 101. Cooling chamber; 102. Control panel; 103. Frame; 104. Fixed chamber; 105. Divider; 106. Chain plate; 107. Top chamber; 108. Bayonet; 109. Storage tank; 110. Horizontal pipe; 111. Through pipe; 112. Partition; 113. Mounting rod; 114. Bottom chamber; 115. Air outlet plate; 116. Slide; 117. Rotating shaft; 118. Rotating seat; 119. Mounting seat; 120. Electric push rod; 121. Nozzle; 122. Fixed plate; 123. Guide vane; 124. Flexible chain; 125. Drive wheel; 126. Fixed shaft; 127. Sealing plate; 128. Opening; 129. Air outlet; 130. Crossbar; 131. Half gear; 132. Gear. Detailed Implementation

[0045] The following description is intended to disclose the invention and enable those skilled in the art to implement it. The preferred embodiments described below are merely examples, and other obvious variations will occur to those skilled in the art.

[0046] like Figures 1-7The cooling device shown includes a cooling chamber 101, inside which are evenly distributed partitions 112. The cooling chamber 101 is divided into multiple cooling chambers by the partitions 112. A frame 103 is installed in the lower part of the cooling chamber 101. Evenly distributed chain plates 106 are installed in the upper part of the frame 103. Fixed shafts 126 are fixedly connected to the middle of both ends of each chain plate 106. Adjacent fixed shafts 126 are connected by flexible chains 124. Each chain plate 106 forms a circulating conveyor belt for transporting storage tanks 109. Evenly distributed horizontal pipes 110 are fixedly connected to the top of the cooling chamber 101. The horizontal pipes 110 are connected to each other by through pipes 111, which are located away from the horizontal pipes. One end of each 110 is fixedly connected to a slide block 116, which is slidably connected to both sides of the top of the frame 103. A mounting rod 113 runs through the middle of each slide block 116, and the mounting rod 113 is installed on both sides of the top of the frame 103. A nozzle 121 is fixedly connected to the side of each slide block 116 near the chain plate 106. A top chamber 107 is installed on the top of the cooling chamber 101. A compressor refrigeration component and a refrigeration unit exhaust pump are installed inside the top chamber 107. The outlet of the refrigeration unit exhaust pump is connected to the inside of the horizontal pipe 110. A reserved opening is opened in the middle of both sides of the cooling chamber. A uniformly distributed partition plate 105 is fixedly connected to the top of each reserved opening. A control panel 102 is installed on the front side of the cooling chamber 101. The control panel 102 is used for other drive equipment.

[0047] Furthermore, in practical implementation, the produced pharmaceutical intermediates can be stored through storage tank 109. Before storage, storage tank 109 and the pharmaceutical intermediates inside it can be cooled by passing through cooling chamber 101 to meet storage conditions. During cooling, the compressor refrigeration component inside top chamber 107 cools the extracted air. The generated cold air is introduced into horizontal pipe 110 by the refrigeration unit's outlet pump. Through horizontal pipe 110, the cold air is further introduced into through pipe 111. Through the sliding end of through pipe 111... The base 116 and nozzle 121 can vent cold air to cool the internal cooling chamber of the cooling chamber 101, thereby cooling the storage tank 109 that enters the cooling chamber. The partition 112 can divide the interior of the cooling chamber 101 into multiple cooling chambers, thereby effectively dividing the internal space of the cooling chamber 101. This avoids the airflow exchange caused by the storage tank 109 entering and exiting the cooling chamber 101 at both ends from affecting the heat distribution of the remaining space. Moreover, multiple small individual spaces are conducive to the rapid filling of cold air and the rapid cooling of the storage tank 109, which is beneficial to practical use.

[0048] Each of the chain plates 106 has a bayonet 108 in the middle, which is used to connect to the mounting base 119. Each mounting base 119 has a rotating seat 118 on its top. Each mounting base 119 has a fixed plate 122 rotatably connected to its upper side through the rotating seat 118. Each fixed plate 122 has a uniformly distributed guide plate 123 fixedly connected to its outer periphery. Each fixed plate 122 has a storage tank 109 in the middle of its top. Each fixed plate 122 has a uniformly distributed electric push rod 120 installed inside its inner side. Each electric push rod 120 is used to fix the bottom of the storage tank 109. Each mounting base 119 has a mounting post fixedly connected to its bottom middle, and the mounting post is engaged inside the bayonet 108.

[0049] Furthermore, in specific implementation, people can select appropriate mounting bases 119 and fixing plates 122 according to the actual size of the storage tank 109. Then, the mounting base 119 is installed into the bayonet 108 through the mounting column. During installation, the installation spacing of the mounting bases 119 can be controlled according to the requirements of cooling time and cooling rate. After the mounting bases 119 are installed, people can place the storage tank 109 on the upper inner side of the fixing plate 122. When the sensor on the top inner side of the fixing plate 122 senses the storage tank 109, it will activate the electric push rod 120. The operation of the electric push rod 120 can achieve the clamping and fixing of the storage tank 109.

[0050] Fixed compartments 104 are installed on the upper and middle parts of both sides of the frame 103. Rotary shafts 117 are set on the upper and lower parts of both sides of the circulating conveyor belt. Drive wheels 125 are fixedly connected to both sides of the outer periphery of the rotating shafts 117. The drive wheels 125 are used to drive the circulating conveyor belt. A geared motor is installed at the end of one of the rotating shafts 117. The geared motors are installed inside the fixed compartments 104. A bottom compartment 114 is set on the upper part of the inner side of the circulating conveyor belt. The bottom compartment 114 is fixedly connected to the upper part of the inner side of the frame 103.

[0051] Furthermore, in specific implementation, people can start the geared motor inside the fixed compartment 104 through the control panel 102. The geared motor can drive the rotating shaft 117 to rotate. The drive wheel 125 on the rotating shaft 117 can drive the fixed shaft 126 to move. This allows the circulating conveyor belt to rotate cyclically, thereby guiding the storage tank 109 into the cooling compartment 101.

[0052] Among them, the side of the pipe 111 near the storage tank 109 is fixedly connected to the air outlet plate 115. The air outlet plate 115 is provided with an inclined airflow channel and is connected to the inside of the pipe 111. The airflow channel is provided with an air outlet 129 at the end. The air outlet 129 is provided on the side of the air outlet plate 115 near the storage tank 109. The middle side of the air outlet plate 115 is slidably connected to the sealing plate 127. The sealing plate 127 is provided with an opening 128 on one side. The bottom side of the sealing plate 127 is provided with a toothed groove 132. The bottom side of the air outlet plate 115 near the storage tank 109 is rotatably connected to the crossbar 130. The end of the crossbar 130 is fixedly connected to the half gear 131. The half gear 131 is meshed with the toothed groove 132. The crossbar 130 and the air outlet plate 115 are both equipped with a torsion spring for resetting.

[0053] Furthermore, in specific implementation, when the circulating conveyor belt moves the storage tank 109, the storage tank 109 will encounter the crossbar 130. The movement of the storage tank 109 can abut against the crossbar 130, thereby causing the crossbar 130 to deflect. The half gear 131 at the end of the crossbar 130 can drive the sealing plate 127 to move through the tooth groove 132, thereby moving the opening 128 on the sealing plate 127 to match the airflow channel inside the vent plate 115, thus enabling the air to flow out. The airflow channels inside the air plate 115 are unobstructed, allowing cold air to be ejected from the air outlet 129 through these channels, forming a cool airflow that cools the entire storage tank 109. The staggered distribution of the side pipes 111 prevents the airflow from the outlets 129 from colliding with the storage tank 109, thus avoiding a decrease in gas velocity and affecting the heat dissipation rate of the storage tank 109, which is beneficial for cooling. As the device continues to move forward and disengages from the crossbar 130, the torsion spring at the bottom of the vent plate 115 resets the crossbar 130. This allows the half gear 131 to synchronously reset the sealing plate 127, which then blocks the airflow channel inside the vent plate 115, effectively reducing the output rate of cold air. This achieves automatic control, with cold air exiting when the storage tank 109 moves and stopping when the storage tank 109 moves, avoiding ineffective cold air output and improving practical use. During cooling, when the storage tank 109 is moved between the nozzles 121, the ejected cold air encounters the guide vanes 123 on the fixed plate 122. The guide vanes 123 cause the fixed plate 122 and the upper storage tank 109 to rotate, allowing the storage tank 109 to fully contact the cold air flow on both sides, further improving the cooling efficiency of the storage tank 109 and the internal pharmaceutical intermediates, thus increasing work efficiency.

[0054] One cooling method for producing a pharmaceutical intermediate includes the following cooling steps:

[0055] S1. Preparations before operation

[0056] S1.1. Start the equipment self-test via the control panel 102 at the front of the cooling chamber 101 to confirm that the compressor refrigeration components, refrigeration unit exhaust pump, geared motor, servo motor and other drive equipment are operating normally and there are no fault alarms; check that the partition 112, chain plate 106 and circulating conveyor belt in the cooling chamber 101 are not stuck or deformed, the sealing plate 127 and crossbar 130 of the exhaust plate 115 are in good reset state, and the torsion spring is in normal elasticity; confirm that the refrigeration system pipeline in the top chamber 107 is sealed and there is no cold air leakage; the nozzle 121 and the air outlet 129 are not blocked; set the refrigeration temperature and circulating conveyor belt running speed via the control panel 102 according to the cooling requirements of the pharmaceutical intermediate, such as target temperature and cooling time.

[0057] S1.2. Based on the specifications and size of the storage tank 109, select the matching mounting base 119 and fixing plate 122, and determine the installation spacing of the mounting base 119 on the chain plate 106 according to the cooling rate requirements.

[0058] S2. Loading and securing

[0059] S2.1. Engage the mounting post at the bottom of the mounting base 119 into the slot 108 in the middle of the chain plate 106 to ensure a secure and loose installation.

[0060] S2.2 Place the storage tank 109 containing the pharmaceutical intermediate in the inner area of ​​the top center of the fixed plate 122;

[0061] S2.3 After the sensor on the inner side of the top of the fixed plate 122 senses the storage tank 109, it automatically starts the electric push rods 120 that are evenly distributed on the inner side. The electric push rods extend and retract to clamp the bottom of the storage tank 109, ensuring that the storage tank is stable and does not shake.

[0062] S3, Start the cooling system

[0063] S3.1. Start the geared motor inside the fixed compartment 104 through the control panel 102. The motor drives the rotating shaft 117 to rotate. The drive wheel 125 on the rotating shaft drives the circulating conveyor belt to rotate in a cycle through the fixed shaft 126, gradually guiding the mounting base containing the storage tank 109 into the cooling compartment 101.

[0064] S3.2. Simultaneously start the compressor refrigeration components and the refrigeration unit outlet pump in the top compartment 107. The refrigeration components cool the extracted air, and the refrigeration unit outlet pump introduces the cold air into the horizontal pipe 110, and then distributes it through the pipe 111 to the corresponding slide 116 and outlet plate 115 of each cooling chamber.

[0065] S4, Cooling Process Monitoring

[0066] S4.1 When the circulating conveyor belt moves the storage tank 109 to a certain cooling chamber, the storage tank will press against the crossbar 130 at the bottom of the air outlet plate 115 in that area, causing the crossbar to deflect. Through the meshing transmission of the half gear 131 and the tooth groove 132, the sealing plate 127 is pushed to move, so that the opening 128 on the sealing plate is aligned with the airflow channel inside the air outlet plate, and cold air is sprayed out from the air outlet 129 to cool the storage tank.

[0067] S4.2 After the storage tank continues to move and disengages from the crossbar 130, the torsion spring drives the crossbar to reset, and the sealing plate 127 resets simultaneously, cutting off the airflow channel and stopping the cold air output, thus realizing "air out when the tank arrives and air stops when the tank moves".

[0068] S4.3 When the storage tank 109 moves between the nozzles 121, the cold air ejected from the nozzles impacts the guide vanes 123 on the outer periphery of the fixed plate 122, causing the fixed plate to rotate around the mounting base 119 via the rotating seat 118, so that the storage tank is evenly contacted by the cold airflow, thereby improving the cooling efficiency.

[0069] S4.4 The circulating conveyor belt drives the storage tank through multiple cooling chambers in the cooling chamber 101 in sequence. The partition 112 prevents airflow exchange between chambers, ensuring stable cold air in each chamber and realizing continuous gradient cooling.

[0070] S5. Discharge and Subsequent Operations

[0071] S5.1 After the storage tank 109 completes the cooling process of all cooling chambers, it is transported by a circulating conveyor belt to the discharge end of the cooling chamber 101, where it is removed manually or by a robotic arm.

[0072] S5.2 After all storage tanks have discharged, shut down the refrigeration system and the transmission mechanism in sequence through the control panel 102. After the equipment has completely stopped, clean the debris in the cooling chamber and check whether there are any impurities remaining in the nozzles 121 and the air outlets 129. If necessary, clear the blockages.

[0073] S5.3 Turn off the main power supply and record the process parameters of this cooling operation, such as cooling temperature and running time, to provide a reference for subsequent production.

[0074] Working principle:

[0075] In practical use, the storage tank 109 can be used to store the produced pharmaceutical intermediates. Before storage, the storage tank 109 and the pharmaceutical intermediates inside it are cooled by passing through the cooling chamber 101 to meet the storage conditions. In specific use, appropriate mounting bases 119 and fixing plates 122 can be selected according to the actual size of the storage tank 109. The mounting bases 119 are then installed into the bayonet 108 using mounting posts. During installation, the installation spacing of the mounting bases 119 can be controlled according to the required cooling time and cooling rate. After all the mounting bases 119 are installed, the storage tank 109 can be placed on the inner side of the upper part of the fixing plate 122. When the sensor on the inner side of the top of the fixing plate 122 senses... After the storage tank 109 is activated, the electric push rod 120 is engaged to clamp and fix the storage tank 109. Then, the geared motor inside the fixing chamber 104 is activated via the control panel 102. This geared motor drives the rotating shaft 117 to rotate, and the drive wheel 125 on the rotating shaft 117 moves the fixed shaft 126 via the fixed shaft 126. This causes the circulating conveyor belt to rotate, guiding the storage tank 109 into the cooling chamber 101. During cooling, the compressor refrigeration unit inside the top chamber 107 cools the extracted air. The produced cold air is then guided by the refrigeration unit's outlet pump into the horizontal pipe 110, where it is cooled. The cold air is further introduced into the through pipe 111, and through the slide 116 and nozzle 121 at the end of the through pipe 111, the cold air can be discharged to cool the cooling chamber inside the cooling chamber 101, thereby cooling the storage tank 109 that enters the cooling chamber. The partition 112 can divide the interior of the cooling chamber 101 into multiple cooling chambers, thereby effectively dividing the internal space of the cooling chamber 101. This can prevent the airflow exchange caused by the storage tank 109 entering and exiting the cooling chamber 101 from affecting the heat distribution of other spaces. Moreover, multiple small individual spaces are conducive to the rapid filling of cold air and the rapid cooling of the storage tank 109, which is beneficial to practical use. When the circulating conveyor belt moves the storage tank 109, the storage tank 109 will encounter the crossbar 13. The movement of the storage tank 109 can push against the crossbar 130, causing the crossbar 130 to deflect. The half-gear 131 at the end of the crossbar 130, via its tooth groove 132, can move the sealing plate 127, causing the opening 128 on the sealing plate 127 to align with the airflow channel inside the vent plate 115. This ensures unobstructed airflow within the vent plate 115, allowing cold air to be ejected from the vent 129, forming a cool airflow that cools the entire storage tank 109. The staggered distribution of the two side pipes 111 prevents the airflow from colliding with the storage tank 109, thus avoiding a decrease in gas velocity due to airflow collision.The reduced heat dissipation rate of storage tank 109 is beneficial for cooling. When storage tank 109 is driven forward and disengages from crossbar 130, the torsion spring at the bottom of vent plate 115 resets crossbar 130. This allows half gear 131 to synchronously reset sealing plate 127, blocking the airflow channel inside vent plate 115 and effectively reducing the output rate of cold air. This achieves the goal of "from storage tank 109 to cold air outlet, storage tank 109 moving..." The automatic control of "cooling stop" avoids ineffective cooling output, which is beneficial for practical use. During cooling, when the storage tank 109 is moved between the nozzles 121, the sprayed cold air encounters the guide vanes 123 on the fixed plate 122. The guide vanes 123 drive the fixed plate 122 and the upper storage tank 109 to rotate, allowing the entire body of the storage tank 109 to fully contact the cooling airflow on both sides, thereby further improving the cooling efficiency of the storage tank 109 and the internal pharmaceutical intermediates, and improving work efficiency.

[0076] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely principles of the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claimed invention. The scope of protection claimed by the appended claims and their equivalents is defined.

Claims

1. A cooling device for the production of pharmaceutical intermediates, comprising a cooling chamber (101), characterized in that: The cooling chamber (101) is equipped with evenly distributed partitions (112). The cooling chamber (101) is divided into multiple cooling chambers by the partitions (112). A frame (103) is installed in the lower part of the cooling chamber (101). Evenly distributed chain plates (106) are installed in the upper part of the frame (103). Fixed shafts (126) are fixedly connected to the middle of both ends of the chain plates (106). Adjacent fixed shafts (126) are connected by soft chains (124). The chain plates (106) form a circulating conveyor belt, which is used to transport the storage tank (109). The cooling chamber (101) is fixedly connected to the top of a uniformly distributed horizontal pipe (110). The horizontal pipes (110) are all connected to each other through a connecting pipe (111). A slide (116) is fixedly connected to the end of the connecting pipe (111) away from the horizontal pipe (110). A nozzle (121) is fixedly connected to the side of the slide (116) near the chain plate (106). An air outlet plate (115) is fixedly connected to the side of the connecting pipe (111) near the storage tank (109). An inclined airflow channel is provided inside the air outlet plate (115) and is connected to the inside of the connecting pipe (111). Each end is provided with an air outlet (129), which is located on the side of the air outlet plate (115) near the storage tank (109). A sealing plate (127) is slidably connected to one side of the middle of the air outlet plate (115). An opening (128) is provided on one side of the sealing plate (127). A toothed groove (132) is provided on one side of the bottom of the sealing plate (127). A crossbar (130) is rotatably connected to the bottom of the air outlet plate (115) near the storage tank (109). A half gear (131) is fixedly connected to the end of the crossbar (130). The half gear (131) is connected to the toothed groove (128). 132) Engaging connection, a torsion spring for resetting is installed between the crossbar (130) and the air outlet plate (115); a bayonet (108) is opened in the middle of the chain plate (106), the bayonet (108) is used to connect the mounting base (119), a rotating seat (118) is installed on the top of the mounting base (119), a fixed plate (122) is rotatably connected to the upper side of the mounting base (119) through the rotating seat (118), a uniformly distributed guide plate (123) is fixedly connected to the outer periphery of the fixed plate (122), and a storage tank (109) is provided in the middle of the top of the fixed plate (122).

2. The cooling device for producing pharmaceutical intermediates according to claim 1, characterized in that: Fixed compartments (104) are installed on the upper middle part of both sides of the frame (103). Rotary shafts (117) are provided on the upper and lower parts of both sides of the circulating conveyor belt. Drive wheels (125) are fixedly connected to both sides of the outer periphery of the rotating shafts (117). The drive wheels (125) are used to drive the circulating conveyor belt. A geared motor is installed at the end of one of the rotating shafts (117). The geared motor is installed inside the fixed compartment (104). A bottom compartment (114) is provided on the upper inner side of the circulating conveyor belt. The bottom compartment (114) is fixedly connected to the upper inner side of the frame (103).

3. The cooling device for pharmaceutical intermediate production according to claim 1, characterized in that: The slides (116) are all slidably connected to the top two sides of the frame (103), and the middle of each slide (116) is provided with a mounting rod (113), which is installed on the top two sides of the frame (103).

4. A cooling device for the production of pharmaceutical intermediates according to claim 1, characterized in that: The inner side of each fixed plate (122) is equipped with evenly distributed electric push rods (120), which are used to fix the bottom of the storage tank (109).

5. A cooling device for the production of pharmaceutical intermediates according to claim 4, characterized in that: Each mounting base (119) has a mounting post fixedly connected to the middle of its bottom end, and the mounting post is engaged inside the slot (108).

6. A cooling device for the production of pharmaceutical intermediates according to claim 1, characterized in that: The cooling chamber (101) is equipped with a top chamber (107) on top. The top chamber (107) is equipped with a compressor refrigeration assembly and a refrigeration pump. The outlet of the refrigeration pump is connected to the inside of the horizontal pipe (110).

7. A cooling device for the production of pharmaceutical intermediates according to claim 1, characterized in that: Both sides of the cooling chamber have reserved openings in the middle, and the top of each reserved opening is fixedly connected with evenly distributed partition plates (105).

8. A cooling device for the production of pharmaceutical intermediates according to claim 1, characterized in that: A control panel (102) is installed on one side of the front of the cooling chamber (101), and the control panel (102) is used for the other drive devices.

9. A cooling method for producing pharmaceutical intermediates, applied to the cooling apparatus for producing pharmaceutical intermediates as described in any one of claims 1-8, characterized in that: The cooling process includes the following steps: S1. Preparations before operation S1.1 Start the equipment self-test through the control panel (102) at the front of the cooling chamber (101), confirm that the drive equipment is running normally, confirm that the refrigeration system pipeline in the top chamber (107) is sealed and there is no cold air leakage; the nozzle (121) and the air outlet (129) are not blocked. According to the cooling requirements of the pharmaceutical intermediates, set the cooling temperature and the running speed of the circulating conveyor belt through the control panel (102). S1.

2. Based on the size of the storage tank (109), select the matching mounting base (119) and the fixing plate (122), and determine the installation spacing of the mounting base (119) on the chain plate (106) according to the cooling rate requirements. S2. Loading and securing S2.

1. Engage the mounting post at the bottom of the mounting base (119) into the slot (108) in the middle of the chain plate (106) to ensure that the installation is secure and there is no looseness; S2.2 Place the storage tank (109) containing the pharmaceutical intermediates on the inner side of the top center of the fixed plate (122); S2.3 After the sensor on the inner side of the top of the fixed plate (122) senses the storage tank (109), it automatically starts the electric push rod (120) evenly distributed on the inner side, and clamps the bottom of the storage tank (109) by extending and retracting the electric push rod to ensure that the storage tank is stable and does not shake. S3, Start the cooling system S3.

1. Start the geared motor inside the fixed chamber (104) through the control panel (102). The motor drives the rotating shaft (117) to rotate. The drive wheel (125) on the rotating shaft drives the circulating conveyor belt to rotate in a cycle through the fixed shaft (126), gradually guiding the mounting seat containing the storage tank (109) into the cooling chamber (101). S3.

2. Simultaneously start the compressor refrigeration components and the refrigeration pump in the top compartment (107). The refrigeration components cool the extracted air, and the refrigeration pump guides the cold air into the horizontal pipe (110), and then distributes it to the corresponding slide (116) and air outlet plate (115) of each cooling chamber through the connecting pipe (111). S4, Cooling Process Monitoring S4.1 When the circulating conveyor belt moves the storage tank (109) to a certain cooling chamber, the storage tank will press against the crossbar (130) at the bottom of the air outlet plate (115) of the cooling chamber, causing the crossbar to deflect. Through the meshing transmission of the half gear (131) and the tooth groove (132), the sealing plate (127) is pushed to move, so that the opening (128) on the sealing plate is aligned with the airflow channel inside the air outlet plate, and the cold air is sprayed out from the air outlet (129) to cool the storage tank. S4.2 After the storage tank continues to move and disengages from the crossbar (130), the torsion spring drives the crossbar to reset, and the sealing plate (127) resets simultaneously, cutting off the airflow channel and stopping the cold air output; S4.3 When the storage tank (109) moves between the nozzles (121), the cold air ejected from the nozzles impacts the guide vanes (123) on the outer periphery of the fixed plate (122), causing the fixed plate to rotate around the mounting base (119) via the rotating seat (118), so that the storage tank is evenly contacted by the cold airflow, thereby improving the cooling efficiency. S4.4 The circulating conveyor belt drives the storage tank through multiple cooling chambers in the cooling chamber (101) in sequence. The partition (112) prevents airflow exchange between chambers, ensuring stable cold air in each chamber and realizing continuous gradient cooling. S5. Discharge and Subsequent Operations S5.1 After the storage tank (109) completes the cooling process of all cooling chambers, it is transported by a circulating conveyor belt to the discharge end of the cooling chamber (101) and removed manually or by a robotic arm. S5.2 After all storage tanks discharge, shut down the refrigeration system and transmission mechanism in sequence through the control panel (102). After the equipment is completely shut down, clean up the debris in the cooling chamber, check whether there are any residual impurities in the nozzle (121) and air outlet (129), and clear any residual impurities.

Images