Animal experiment workbench

Abstract

The invention discloses an animal experiment workbench which comprises a base, a supporting plate, an operation table, a fixing piece, an anesthesia cabin, a partition plate, a sliding plate, a gas sensor, a control unit, an alarm module, a display module, a liquid medicine supplementing mechanism and a spray head. The operation table is arranged above the base, and the two ends of the operation table are connected with the upper surface of the base through supporting plates. The fixing pieces are arranged on the surface of the operation table and used for fixing the limbs, the trunk and the head of an experimental animal; the anesthesia cabin is arranged at the front end of the operation table; the anesthesia cabin is of a hollow structure with one end opened and the other end sealed, and the partition plate is arranged in the anesthesia cabin and divides the anesthesia cabin into a head containing cabin and a medicament containing cabin. A plurality of air holes which are formed in rows and are used for communicating the head placing cabin with the medicament placing cabin are formed in the plate surface of the partition plate; the sliding plate is slidably arranged on the front plate face of the partition plate. The animal experiment workbench can overcome the defects that the concentration of anesthetic gas cannot be monitored in real time and anesthetic needs to be manually supplemented in the prior art.

Description

Technical Field

[0001] This invention relates to the field of laboratory equipment technology, and in particular to an animal laboratory workbench. Background Technology

[0002] In scientific research fields such as biomedicine and drug development, in vivo experiments using model animals such as mice and rats are an indispensable and crucial step. These experiments typically require safe, stable, and controllable general anesthesia for procedures such as surgery, imaging examinations, or behavioral observations. Inhalation anesthesia (such as that using isoflurane or sevoflurane) has become one of the most commonly used anesthesia methods in laboratories due to its advantages, including easily controllable depth of anesthesia, rapid animal recovery, and relatively minimal interference with physiological functions.

[0003] Currently, the basic equipment widely used in laboratories can be called a "traditional animal anesthesia workbench" or a "simple anesthesia chamber." Its typical operation is as follows: a sealed container (i.e., the anesthesia chamber) serves as the space for anesthesia induction and maintenance. Cotton balls or gauze soaked in liquid inhalation anesthetics (such as isoflurane) are placed inside as a vapor source. During anesthesia, the experimental animal is placed inside the chamber or its mouth and nose are fixed to the sealed interface of the chamber. The animal breathes a mixture of gases containing anesthetic vapors within the chamber.

[0004] However, this traditional method of anesthesia has several significant technical drawbacks, directly affecting the reliability and efficiency of the experiment:

[0005] 1. Unknown and uncontrollable anesthetic concentration: The concentration of inhaled anesthetic gas in the anesthesia chamber is a crucial parameter for controlling the depth of anesthesia, but traditional devices are completely unable to monitor it in real time. The concentration mainly depends on the initial amount of anesthetic on the cotton ball, the evaporation area, the ambient temperature, and the animal's metabolic consumption, all of which are dynamic. Therefore, the effective anesthetic concentration in the chamber will unpredictably decrease over time, leading to a gradual decline in the depth of anesthesia.

[0006] 2. Anesthesia maintenance relies on manual experience and intermittent intervention: Researchers cannot know the real-time concentration within the chamber and can only indirectly and reactively judge the depth of anesthesia by observing the animal's physiological reflexes (such as the pinching reflex). When it is judged that the anesthesia may be too shallow, only empirical manual supplementation methods can be used, such as opening the chamber lid and adding anesthesia solution to a cotton ball. This method is highly subjective, reactive, and prone to interference. Inaccurate timing and dosage of supplementation can easily cause fluctuations in the depth of anesthesia, and may even lead to intraoperative awakening (too shallow anesthesia) or respiratory depression (too deep anesthesia).

[0007] 3. The operation is cumbersome and affects the experimental process: Frequent opening of the chamber for inspection and manual replenishment of anesthetic not only interrupts continuous experimental operations (such as surgery and microscopic imaging) and introduces unnecessary interference, but also increases the risk of anesthetic exposure to the experimental environment and personnel.

[0008] The aforementioned defects may result in a "blind operation" during the anesthesia process, leading to poor stability of the depth of anesthesia. In severe cases, this may endanger experimental animals, introduce experimental variables, affect the consistency and reproducibility of data, and reduce the overall experimental efficiency. Summary of the Invention

[0009] The purpose of this invention is to provide an animal experimental workbench to overcome the shortcomings of existing technologies that cannot monitor the concentration of anesthetic gas in real time and require manual replenishment of anesthetic agents.

[0010] To solve the above-mentioned technical problems, the present invention adopts the following technical solution:

[0011] An animal experimental workbench includes a base, a support plate, an operating table, fixing components, and an anesthesia chamber. The operating table is positioned above the base, and its two ends are connected to the upper surface of the base via the support plate. The fixing components are located on the surface of the operating table and are used to fix the limbs, torso, and head of the experimental animal. The anesthesia chamber is located at the front end of the operating table. A distinguishing feature is that the animal experimental workbench also includes a partition, a sliding plate, a gas sensor, a control unit, an alarm module, a display module, a drug replenishment mechanism, and a nozzle. The anesthesia chamber is a hollow structure with one open end and the other closed. The partition is located inside the anesthesia chamber, dividing it into a head placement chamber and a drug placement chamber. The surface of the partition... The partition is equipped with multiple air vents arranged to connect the head placement chamber and the drug placement chamber; a sliding plate is slidably mounted on the front panel of the partition, and moving the sliding plate can expose or close different numbers of air vents; at least two gas sensors are provided, evenly distributed in the head placement chamber and the drug placement chamber, to detect the concentration of anesthetic gas in the head placement chamber and the drug placement chamber, respectively; a drug replenishment mechanism is connected to a nozzle, which is located above the cotton ball; the control unit is electrically connected to the gas sensors, the alarm module, the display module, and the drug replenishment mechanism; when the gas concentration in the drug placement chamber is less than the set range, the control unit controls the drug replenishment mechanism to work and sprays anesthetic supplement through the nozzle.

[0012] The animal experimental workbench provided by this invention has the following significant advantages compared to the prior art:

[0013] 1. By installing multiple gas sensors in the head placement chamber and the drug placement chamber, the system can monitor the concentration of anesthetic gas in the respiratory area (head placement chamber) and the anesthetic evaporation source (drug placement chamber) of the experimental animal in real time and with high precision. When the anesthetic concentration in the drug placement chamber falls below the set threshold due to evaporation, the control unit can automatically activate the drug replenishment mechanism to replenish the anesthetic in a quantitative manner through the nozzle. This achieves automatic and precise compensation of the anesthetic dosage. This closed-loop control mechanism completely replaces the manual replenishment method that relies on human experience and intermittent chamber checks, ensuring the continuous stability of the anesthetic gas concentration. It effectively avoids insufficient anesthesia (intraoperative awakening) or concentration fluctuations caused by unpredictable decreases in concentration, providing a basis for an animal model with a constant physiological state for experiments.

[0014] 2. Through the collaborative design of the sliding plate and the multi-pore partition, the user can adjust the gas exchange rate between the two chambers by simply sliding the sliding plate to adjust the number of exposed pores without opening the anesthesia chamber or interrupting the experiment, based on the feedback alarm (concentration too high or too low) from the gas sensor in the head placement chamber. This allows for precise and rapid adjustment of the concentration of anesthetic gas inhaled by the animal, ensuring timely adjustment while greatly reducing interference with the experimental process and exposure of the operator to anesthetics. Attached Figure Description

[0015] One or more embodiments of the invention will now be described by way of example only with reference to the accompanying drawings, in which:

[0016] Figure 1 This is a schematic diagram of the structure of the present invention in use.

[0017] Figure 2 This is a schematic diagram of the structure of the present invention after omitting the anesthesia chamber.

[0018] Figure 3 This is a cross-sectional view of the base, support plate, and operating table of the present invention in their connected state.

[0019] Figure 4 This is a schematic diagram of the anesthesia chamber of the present invention.

[0020] Figure 5 This is a cross-sectional view of the anesthesia chamber of the present invention.

[0021] Figure 6 This is a cross-sectional view of the limb fixation component of the present invention.

[0022] Figure 7 This is a cross-sectional view of the sliding plate and the sliding groove of the present invention in the connected state.

[0023] Figure 8 This is a circuit block diagram of the present invention.

[0024] Figure 9This is a circuit diagram of the power module of the present invention.

[0025] Figure 10 This is a circuit diagram showing the connection between the microcontroller module and the gas sensor, button module, alarm module, display module, and liquid pump of the present invention.

[0026] The diagram is labeled as follows: 1. Base; 2. Support plate; 21. Receiving groove; 22. Locking screw; 3. Operating table; 31. Rotating shaft; 32. Rotating column; 41. Limb fixation component; 411. Fixing seat; 412. Locking block; 413. Pressure block; 414. Wing screw; 415. Fastener; 416. Limiting ring; 417. Annular groove; 42. Torso fixation component; 421. Fixing rod; 422. Restraint strap; 43. Head fixation component; 431. Limiting column; 432. Limiting plate; 433. Wing nut; 5. Anesthesia chamber; 51. Head placement chamber; 52. 53. Medicine storage compartment; 6. Sliding cover; 7. Partition plate; 8. Vent; 9. Slide groove; 10. First protrusion; 11. Sliding plate; 12. Sliding block; 13. Second protrusion; 14. Gas sensor; 15. Control unit; 16. Housing; 17. Microcontroller module; 18. Power supply module; 19. Button module; 10. Alarm module; 20. Display module; 21. Medicine replenishment mechanism; 22. Storage tank; 23. Suction pipe; 24. Drain pipe; 25. Suction pump; 26. Nozzle; 27. Cotton ball placement plate; 28. Placement groove; 29. ​​Limiting block. Detailed Implementation

[0027] The present invention will now be described in detail with reference to exemplary embodiments shown in the accompanying drawings. However, it should be understood that the present invention may be implemented in many different forms and should not be construed as limited to the embodiments set forth herein. These embodiments are provided herein to make the disclosure of the present invention more complete and to fully convey the inventive concept to those skilled in the art.

[0028] In the description of this invention, it should be understood that the terms "center," "lateral," "longitudinal," "front," "rear," "left," "right," "upper," "lower," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limiting the scope of protection of this invention.

[0029] like Figures 1 to 10As shown, the animal experimental workbench of this embodiment includes a base 1, a support plate 2, an operating table 3, a fixing component 4, an anesthesia chamber 5, a partition 6, a sliding plate 7, a gas sensor 8, a control unit 9, an alarm module 10, a display module 20, a drug replenishment mechanism 30, and a nozzle 40.

[0030] The operating table 3, used to place experimental animals, is positioned above the base 1. Both ends of the operating table 3 are connected to the upper surface of the base 1 via support plates 2. In this embodiment, two support plates 2 are provided, one at the front end and the other at the rear end of the operating table 3. The front end of the operating table 3 is hinged to the surface of the front support plate 2. A rotating shaft 31 is located along the centerline of the rear end of the operating table 3, and a rotating column 32 coaxial with the shaft 31 is mounted on the shaft 31. The rear support plate 2 has a receiving groove 21 for accommodating the rotating column 32, and its surface has a through hole communicating with the receiving groove 21. The rotating column 32 is positioned within the receiving groove 21 and can rotate within it about its central axis. The rotating shaft 31 extends out of the receiving groove 21 through the through hole, and a handle is provided at the end of the shaft not connected to the operating table 3. A locking screw 22 is located on the side wall of the rear support plate 2, the end of which can be screwed into the receiving groove 21 to secure the rotating column 32. After loosening the locking screw 22, the handle can be gripped to rotate the shaft 31, thereby rotating the operating table 3. This allows for experiments to be performed at different angles. Tightening the locking screw 22 causes its end to press tightly against the side wall of the rotating column 32, generating friction and preventing the rotating column 32 from rotating, thus fixing the operating table 3 in its rotated position. The surface of the operating table 3 has an opening for exposing the abdomen of the experimental animal, facilitating abdominal experiments.

[0031] The fasteners are installed on the surface of the operating table 3 and are used to fix the limbs, torso, and head of the experimental animal. In this embodiment, the fasteners include a limb fastener 41, a torso fastener 42, and a head fastener 43.

[0032] The limb fixation component 41 includes a fixing base 411, a locking block 412, a pressure block 413, and a wing screw 414. Both the locking block 412 and the fixing base 411 are U-shaped thick blocks. The locking block 412 is inverted and fastened to the upper surface of the base 411, forming a U-shaped hole for fixing the experimental animal's limbs. One side of the locking block 412 is hinged to the side of the upper surface of the fixing base 411. A latch 415 is provided on the side of the fixing base 411 opposite to the hinged side to fix the locking block 412 to the fixing base 411. A limit ring 416 is fixedly connected to the end of the wing screw 414. The upper surface of the locking block 412 has a threaded hole. The end of the wing screw 414 with the limit ring 416 passes through the threaded hole into the U-shaped hole and is threadedly connected to the threaded hole. The pressure block 413 is disposed inside the U-shaped hole. A circular hole is formed on the upper surface of the pressure block 413, and an annular groove 417 is formed on the inner wall of the circular hole. The winged screw 414 can pass through the circular hole, and its end retaining ring 416 is rotatably connected to the annular groove 417 inside the circular hole. In use, the limbs of the experimental animal are placed in the fixing seat 411, then the locking block 412 is closed, the buckle 415 is fastened, and the winged screw 414 is rotated downwards, causing the retaining ring 416 to press tightly against the animal's limbs, thereby fixing the animal's limbs.

[0033] The torso fixation component 42 includes two sets of fixing rods 421 symmetrically arranged on both sides of the operating table surface and a restraint strap 422. One end of the restraint strap 422 is fixed to one of the fixing rods 421, and the other end crosses the operating table 3 and wraps around the fixing rod 421 on the other side before being attached to the strap body with Velcro. In use, the end of the restraint strap 422 with Velcro is crossed over the animal's back, then wrapped around the fixing rod 421 on the other side before being attached to the strap body with Velcro, thus fixing the animal's torso between the restraint strap 422 and the operating table 3.

[0034] The head fixing component 43 includes a limiting post 431, a limiting plate 432, and a wing nut 433. Two limiting posts 431 are provided, located on both sides of the front surface of the operating table 3, and each limiting post 431 has an external thread. The limiting plate 432 is arc-shaped, with through holes at both ends for inserting the limiting posts 431; each through hole corresponds to one limiting post 431. The wing nut 433 is located on the upper surface of the limiting plate 432 and is threadedly connected to the limiting post 431. In use, the animal's neck is placed between the two limiting posts 431 and below the limiting plate 432, and then the wing nut 433 is tightened to bring the limiting plate 432 into contact with the animal's neck, thus fixing the animal's head.

[0035] Anesthesia chamber 5 is detachably mounted at the front end of operating table 3. Anesthesia chamber 5 is a hollow structure with one end open and the other end closed. An insertion block is provided on the lower surface of the anesthesia chamber, and a slot for inserting the insertion block is provided on the upper surface of operating table 3. A partition 6 is provided inside the anesthesia chamber 5, dividing the anesthesia chamber 5 into a head placement chamber 51 and a drug placement chamber 52. The head placement chamber 51 is used to insert the head of the experimental animal, and the drug placement chamber 52 is used to place cotton balls soaked in anesthetic. In this embodiment, a cotton ball placement plate 50 is provided inside the drug placement chamber 52. The two sides of the cotton ball placement plate 50 are slidably connected to the inner walls of the two sides of the drug placement chamber 52. A sliding cover 53 is provided at the rear end of the drug placement chamber 52. After sliding the sliding cover 53 upward, the cotton ball placement plate 50 can be removed from the drug placement chamber 52. The cotton ball placement plate 50 has multiple placement slots 501 for placing cotton balls on its surface. Limiting blocks 502 are provided on the placement slots 501 to prevent the cotton balls from falling out of the placement slots 501.

[0036] The partition 6 has multiple air holes 61 arranged on its surface to connect the head placement chamber 51 and the drug placement chamber 52. After the anesthetic in the drug placement chamber 52 evaporates, the gas generated is discharged into the head placement chamber 51 through the air holes 61, making it convenient for experimental animals to inhale the anesthetic gas.

[0037] A sliding plate 7 is slidably disposed on the front surface of the partition 6. Moving the sliding plate 7 can expose or close different numbers of air holes 61. In this embodiment, a sliding plate 7 is disposed in front of each row of air holes 61. The partition 6 on both sides of each row of air holes 61 is provided with a groove 62. Multiple first protrusions 63 are spaced apart along the height direction in the groove 62. Slider blocks 71 embedded in the groove 62 are disposed on both sides of the sliding plate 7. Multiple second protrusions 72 are spaced apart along the height direction on the sidewall of the slider 71. The second protrusions 72 can elastically engage with the groove 62. Between the two first protrusions 63 on the same side, the upper surface of the anesthesia chamber 5 is provided with a plate hole extending from the upper end of the sliding plate 7. By using a certain amount of force to pull upward or push downward the end of the sliding plate 7 outside the anesthesia chamber 5, a different number of air holes 61 can be exposed, which can physically change the gas exchange rate between the two chambers, thereby finely and quickly adjusting the concentration of anesthetic gas inhaled by the animal. After releasing the hand, the second protrusion 72 is located between the two first protrusions 63, making the sliding plate 7 less likely to slide, thereby fixing the adjusted position of the sliding plate 7.

[0038] Two gas sensors 8 are provided, evenly distributed in the head placement chamber 51 and the drug placement chamber 52, respectively, to detect the concentration of anesthetic gas in the head placement chamber 51 and the drug placement chamber 52. The gas sensor in this embodiment is a model MH-440D sensor, which adopts the non-dispersive infrared (NDIR) principle to measure medical anesthetic gases such as isoflurane, sevoflurane, and desflurane.

[0039] The control unit 9 includes a housing 91 mounted on the surface of the anesthesia chamber 5, a microcontroller module 92 and a power module 93 mounted inside the housing 91, and a button module 94 mounted on the surface of the housing 91. The microcontroller module 92 is a microcontroller module with an AT32F103AVxT7 microcontroller as its core. Both gas sensors 8 are electrically connected to the microcontroller module 92. The microcontroller module 92 converts the detection signals of the gas sensors 8 into anesthetic gas concentration values.

[0040] The power module 93 provides the power supply voltage and includes a battery, a charging circuit for charging the battery, a boost circuit, a buck circuit, and a USB charging interface. The USB charging interface is located on the side wall of the housing 91 and is electrically connected to the input terminal of the charging circuit for connecting the charging cable. The charging circuit uses a TC4056A chip, and its output terminal is electrically connected to the input terminal of the battery. The output terminal of the battery is electrically connected to the input terminal of the boost circuit. The boost circuit uses a KF2185 chip to boost the output voltage of the battery to a 5V DC voltage.

[0041] The button module 94 is electrically connected to the microcontroller module 92. It includes a power button, which is connected between the battery output terminal and the input terminal of the boost circuit, and is represented by K10 in the circuit.

[0042] The alarm module 10 is disposed inside the housing 91 and is electrically connected to the microcontroller module 92. In this embodiment, the alarm module 10 includes a red light and a green light disposed on the surface of the housing 91, and a speaker disposed inside the housing 91. The red light and the green light are represented by D1 and D2 respectively in the circuit, and the speaker is represented by SPEEK in the circuit.

[0043] The display module 20 is disposed on the surface of the housing 91 and is electrically connected to the microcontroller module 92. The display module 20 uses an LCD1602 display screen to display the concentration of anesthetic gas detected by the two gas sensors 8.

[0044] The drug replenishment mechanism 30 in this embodiment includes a storage tank 301, a suction pipe 302, a discharge pipe 303, and a pump 304. The storage tank 301 is located beside the anesthesia chamber 5 and is used to store anesthetic supplements. It has a lid for pouring in the anesthetic supplements. The pump 304 is located on the side wall of the anesthesia chamber 5. Its inlet end is connected to the storage tank 301 through the suction pipe 302, and its outlet end is connected to the nozzle 40 through the discharge pipe 303. A nozzle 40 is provided above each placement slot 501. The pump 304 is electrically connected to a microcontroller module 92. When the gas concentration in the drug placement chamber 52 is less than a set range, the microcontroller module 92 controls the pump 304 to work. The pump 304 draws the anesthetic supplements from the storage tank 301, and the anesthetic supplements are sprayed from the nozzles 40 onto cotton balls. The pump 304 is represented by M in the circuit diagram. The button module 94 also includes a manual operation button, represented by K1 in the circuit. After the experimenter manually operates the button, the microcontroller module 92, upon receiving the instruction, controls the liquid pump 304 to operate and extract the anesthetic supplement. The button module 94 also includes setting buttons, represented by K2, K3, and K4 in the circuit, used to set the anesthetic gas concentration threshold in the head placement chamber and the anesthetic gas concentration threshold in the drug placement chamber.

[0045] The method of using this invention is as follows:

[0046] 1. Press the power button to turn on the power. Use the setting button to set the concentration parameters for maintaining anesthesia to the microcontroller module 92, including: setting the upper and lower limits of the concentration of anesthetic gas in the head placement chamber 51 (e.g., 1.3% ~ 1.7%); and setting the minimum replenishment threshold of the concentration of anesthetic gas in the drug placement chamber 52 (e.g., 1.8%).

[0047] 2. Open the sliding cover 53 of the anesthesia chamber 5, take out the cotton ball placement plate 50, put an appropriate amount of cotton balls soaked in anesthetic (such as isoflurane) into the placement slot 501 of the cotton ball placement plate 50, and push the cotton ball placement plate 50 into the drug placement chamber 52, then close the sliding cover 53; add anesthetic supplement to the storage tank 301.

[0048] 3. Based on the species and weight of the experimental animals, the position of the sliding plate 7 is initially adjusted so that a portion of the pores 61 on the partition plate 6 are exposed, forming an initial gas exchange channel.

[0049] 4. Gently place the experimental animal (e.g., a mouse) on the operating table 3. Secure the animal's limbs, torso, and head in sequence using the limb fixation device 41, trunk fixation device 42, and head fixation device 43. Finally, install the anesthesia chamber 5 on the operating table 3, positioning the animal's head within the head placement chamber 51. At this point, the animal begins to breathe anesthetic gas diffused from the drug placement chamber 52 through the vent 61. The operator determines the animal's anesthesia state by observing its behavior (e.g., gradually losing the righting reflex). During this process, the display module 20 displays the gas concentration values ​​in both chambers in real time.

[0050] 5. During the experiment, the two gas sensors 8 work continuously. The gas sensor 8 in the head placement chamber 51 monitors the concentration of anesthetic at the animal's inhalation end in real time; the gas sensor 8 in the drug placement chamber 52 monitors the concentration of the anesthetic volatilization source. The data is fed back to the microcontroller module 92 in real time and displayed on the display module 20.

[0051] 6. If the concentration of anesthetic gas in the head placement chamber 51 is lower than the set lower limit, the microcontroller module 92 triggers the alarm module 10 to issue a prompt (green light flashes and the speaker sounds an alarm). At this time, the operator does not need to open the anesthesia chamber 5. He / She only needs to manually select an appropriate number of sliding plates 7 and move the sliding plates 7 upward to expose more air holes 61 to increase the supply of anesthetic gas to the head placement chamber 51 until the concentration returns to the set range, and the alarm is lifted. If the concentration in the head placement chamber 51 is higher than the set upper limit, the alarm module 10 will also sound an alarm (red light flashes and the speaker sounds an alarm). The operator will then slide the sliding plates 7 in the opposite direction to block some of the air holes 61 to reduce the gas supply and lower the concentration.

[0052] 7. During the experiment, the concentration in the drug placement chamber 52 will slowly decrease due to the evaporation of the anesthetic on the cotton ball. When the concentration in this chamber falls below the preset replenishment threshold, the microcontroller module 92 controls the pump to operate (for 5 seconds; generally, the microcontroller has a timing function), drawing anesthetic supplement from the storage tank 301 and spraying it onto the cotton ball through the nozzle 40, re-wetting the cotton ball and restoring the concentration of the evaporation source. This process is completely automatic and does not require the operator to interrupt the experiment for manual replenishment.

[0053] 8. During the experiment, the locking screw 22 can be loosened and the operating table 3 can be rotated to meet the experimental operation at different angles.

[0054] 9. After the experiment is completed, the sliding plate 7 can be completely closed to block the supply of anesthetic gas, all fasteners can be loosened, and the animal's head can be removed from the head placement chamber 51 to allow it to breathe fresh air and enter the recovery process.

[0055] In summary, the animal experimental workbench provided by this invention, through multiple gas sensors installed in the head placement chamber and the drug placement chamber, enables the system to monitor the concentration of anesthetic gas in the respiratory area (head placement chamber) and the anesthetic evaporation source (drug placement chamber) of the experimental animal in real time and with high precision. When the anesthetic concentration in the drug placement chamber falls below a set threshold due to evaporation, the control unit can automatically activate the drug replenishment mechanism to quantitatively replenish the anesthetic through the nozzle, achieving automatic and precise compensation of the anesthetic dosage. This closed-loop control mechanism completely replaces the manual replenishment method that relies on human experience and intermittent chamber checks, ensuring the continuous stability of the anesthetic gas concentration and effectively avoiding insufficient anesthesia (intraoperative awakening) or concentration fluctuations caused by unpredictable decreases in concentration, thus providing a basis for an animal model with a constant physiological state for experiments. Through the collaborative design of the sliding plate and the multi-pore partition, the user can adjust the gas exchange rate between the two chambers by simply sliding the sliding plate to adjust the number of exposed pores, without opening the anesthesia chamber or interrupting the experiment, based on the feedback alarm (concentration too high or too low) from the gas sensor in the head placement chamber. This allows for precise and rapid adjustment of the concentration of anesthetic gas inhaled by the animal, ensuring timely adjustment while greatly reducing interference with the experimental process and exposure of the operator to anesthetics.

[0056] It should be understood that all the above embodiments are exemplary and not restrictive. Various modifications or variations made by those skilled in the art to the specific embodiments described above under the concept of the present invention should be within the protection scope of the present invention.

Claims

1. An animal experimental workbench, comprising a base (1), a support plate (2), an operating table (3), a fixing component, and an anesthesia chamber (5); the operating table (3) is disposed above the base (1), and the two ends of the operating table (3) are connected to the upper surface of the base (1) through the support plate (2); the fixing component is disposed on the surface of the operating table (3) for fixing the limbs, torso, and head of the experimental animal; the anesthesia chamber (5) is disposed at the front end of the operating table (3); Its features are: It also includes a partition (6), a sliding plate (7), a gas sensor (8), a control unit (9), an alarm module (10), a display module (20), a drug replenishment mechanism (30), and a nozzle (40); the anesthesia chamber (5) is a hollow structure with one end open and the other end closed. The partition (6) is set inside the anesthesia chamber (5) to divide the anesthesia chamber (5) into a head placement chamber (51) and a drug placement chamber (52); the surface of the partition (6) is provided with multiple air holes (61) arranged to connect the head placement chamber (51) and the drug placement chamber (52); the sliding plate (7) is slidably set on the front surface of the partition (6), and moving the sliding plate (7) can expose or close different numbers of air holes. A vent (61) is provided; at least two gas sensors (8) are provided, evenly distributed in the head placement chamber (51) and the drug placement chamber (52), respectively used to detect the concentration of anesthetic gas in the head placement chamber (51) and the drug placement chamber (52); the drug replenishment mechanism (30) is connected to the nozzle (40), which is located above the cotton ball; the control unit (9) is electrically connected to the gas sensor (8), the alarm module (10), the display module (20) and the drug replenishment mechanism (30); when the gas concentration in the drug placement chamber (52) is less than the set range, the control unit (9) controls the drug replenishment mechanism (30) to work and sprays out the anesthetic supplement through the nozzle (40).

2. The animal experimental workbench according to claim 1, characterized in that: The control unit (9) includes a housing (91) disposed on the surface of the anesthesia chamber (5), a microcontroller module (92) and a power module (93) disposed inside the housing (91), and a button module (94) disposed on the surface of the housing (91); the power module (93) is used to provide power supply voltage; the button module (94) is electrically connected to the microcontroller module (92); the alarm module (10) is disposed inside the housing (91) and is electrically connected to the microcontroller module (92); the display module (20) is disposed on the surface of the housing (91) and is electrically connected to the microcontroller module (92); the gas sensor (8) is electrically connected to the microcontroller module (92).

3. The animal experimental workbench according to claim 2, characterized in that: The drug replenishment mechanism (30) includes a storage tank (301), a suction pipe (302), a drain pipe (303), and a suction pump (304). The storage tank (301) is located on the side of the anesthesia chamber (5) and is used to store anesthetic supplements. The suction pump (304) is located on the side wall of the anesthesia chamber (5). Its inlet end is connected to the storage tank (301) through the suction pipe (302), and its outlet end is connected to the nozzle (40) through the drain pipe (303). The suction pump (304) is electrically connected to the microcontroller module (92).

4. The animal experimental workbench according to claim 1, characterized in that: A sliding plate (7) is provided in front of each row of air holes (61). The partition (6) on both sides of each row of air holes (61) is provided with a sliding groove (62). Multiple first protrusions (63) are provided at intervals along the height direction in the sliding groove (62). Slider (71) embedded in the sliding groove (62) is provided on both sides of the sliding plate (7). Multiple second protrusions (72) are provided at intervals along the height direction on the side wall of the slider (71). The second protrusion (72) can be elastically inserted between two first protrusions (63) on the same side. The upper surface of the anesthesia chamber (5) is provided with a plate hole extending from the upper end of the sliding plate (7).

5. The animal experimental workbench according to claim 1, characterized in that: The medicine placement chamber (52) is provided with a cotton ball placement plate (50), and the two sides of the cotton ball placement plate (50) are slidably connected to the inner walls of the two sides of the medicine placement chamber (52); a sliding cover (53) is provided at the rear end of the medicine placement chamber (52), and the cotton ball placement plate (50) can be taken out from the medicine placement chamber (52) by sliding the sliding cover (53) upward; the surface of the cotton ball placement plate (50) is provided with a plurality of placement slots (501) for placing cotton balls, and a limit block (502) is provided on the placement slot (501); a nozzle (40) is provided above each placement slot (501).

6. The animal experimental workbench according to claim 1, characterized in that: The support plate (2) is provided in two parts, which are respectively set at the front end and the rear end of the operating table (3); the front end of the operating table (3) is hinged to the plate surface of the support plate (2) located in front, and the rear end of the operating table (3) is provided with a rotating shaft (31) along its center line, and a rotating column (32) coaxial with it is provided on the rotating shaft (31); the interior of the support plate (2) located at the rear is provided with a receiving groove (21) for accommodating the rotating column (32), and the plate surface of the support plate (2) is provided with a through hole communicating with the receiving groove (21); the rotating column (32) is set in the receiving groove (21) and can rotate in the groove with its center axis as the center; the rotating shaft (31) extends out of the receiving groove (21) through the through hole; the side wall of the support plate (2) located at the rear is provided with a locking screw (22), and the end of the locking screw (22) can be screwed into the receiving groove (21) to fix the rotating column (32).

7. The animal experimental workbench according to claim 1, characterized in that: The fasteners include limb fasteners (41), trunk fasteners (42), and head fasteners (43).

8. The animal experimental workbench according to claim 1, characterized in that: The surface of the operating table (3) is provided with an opening for exposing the abdomen of the experimental animal.

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