Artificial cornea endothelial sheet

Abstract

The invention relates to the technical field of medical instruments, and particularly discloses an artificial corneal endothelium sheet which comprises a main body part and an extension part, the main body part is in a vault shape, and the outer diameter of the main body part is larger than or equal to the diameter of a pupil; the plurality of extension parts are arranged on the periphery of the main body part at intervals; each extension part is in an arc-shaped strip shape, the radian of the extension parts is the same as that of the main body part, the width of the extension parts is gradually reduced in the direction away from the center point of the main body part, and a notch is formed between any two adjacent extension parts. The stability of the artificial corneal endothelium sheet is improved.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and more particularly to an artificial corneal endothelial graft. Background Technology

[0002] Bullous keratopathy is a common blinding eye disease caused by damage to corneal endothelial cells. Due to the limited proliferative capacity of corneal endothelial cells in adults, when intraocular surgery, infection, or genetic diseases lead to damage to corneal endothelial cell function, problems such as subepithelial bullae, corneal edema and opacity, eye pain, and even blindness may occur. Due to the scarcity of corneal donors, only artificial corneal endothelial grafts can be used for transplantation. Existing artificial corneal endothelial grafts still have the following problems: (1) The circular artificial corneal endothelial grafts have poor adhesion to the corneal stroma, and there is a risk of postoperative detachment. (2) In order to improve the adhesion between the artificial corneal endothelial graft and the corneal stroma, clinicians need to suture the artificial corneal endothelial graft to the cornea during the operation. When the suture passes through the corneal tissue, it will directly damage the collagen fibers of the corneal stroma, which may lead to local collagen disorder, affect corneal transparency, and in severe cases, form micro-scars. In addition, improper control of suture tension may lead to abnormal corneal morphology (such as worsening of astigmatism), especially in cases where the cornea itself is thin or has weak healing ability, which will increase the difficulty of postoperative astigmatism correction.

[0003] Therefore, there is an urgent need to research an artificial corneal endothelial graft to solve the above problems. Summary of the Invention

[0004] The purpose of this invention is to provide an artificial corneal endothelial graft to solve the problems of poor stability and unnecessary damage caused by abnormal corneal morphology in existing artificial corneal endothelial grafts.

[0005] To achieve the above objectives, the present invention adopts the following technical solution:

[0006] An artificial corneal endothelial graft, comprising:

[0007] The main body is dome-shaped, and the outer diameter of the main body is greater than or equal to the diameter of the pupil;

[0008] The extension portion has a plurality of extension portions, which are spaced apart on the outer periphery of the main body portion; the extension portion is an arc-shaped strip with the same curvature as the main body portion, and the width of the extension portion gradually decreases along the direction away from the center point of the main body portion, wherein a gap is formed between any two adjacent extension portions.

[0009] As an alternative technical solution for artificial corneal endothelial grafts, the outer contour of the artificial corneal endothelial graft is circular, the chord length of the notch is L1, and the chord length of the end of the extension away from the main body is L2, wherein L1=L2.

[0010] As an alternative technology for artificial corneal endothelial grafts, ,

[0011] D1 is the circumcircle diameter of the artificial corneal endothelial graft, and n is the number of notches.

[0012] As an alternative technical solution for artificial corneal endothelial grafts, the notch is arc-shaped, wherein, R is the radius of the notch, and D2 is the diameter of the circumcircle of the main body.

[0013] As an alternative technology for artificial corneal endothelial grafts,

[0014] The artificial corneal endothelial graft is an aspherical structure, and the equation is: Where c = 1 / R0, c is the vertex curvature of the aspherical surface, R0 is the vertex radius of curvature of the aspherical surface; k is the quadratic curve coefficient; r is the radial coordinate perpendicular to the optical axis; a i r 2i It is a high-order non-spherical item.

[0015] As an alternative technical solution for artificial corneal endothelial grafts, the thickness of the extension gradually decreases along the direction away from the center point of the main body.

[0016] As an alternative technical solution for artificial corneal endothelial grafts, the convex side of the extension portion is at least partially frosted.

[0017] As an alternative technical solution for artificial corneal endothelial grafts, the frosted surface includes a peak-valley structure at the micron or nanometer level.

[0018] As an alternative technical solution for artificial corneal endothelial grafts, the extension portion is provided with marking symbols on the convex or concave side.

[0019] As an alternative technical solution for artificial corneal endothelial grafts, the number of notches ranges from 3 to 9, and several of the notches are evenly distributed on the outer periphery of the main body.

[0020] The present invention has at least the following beneficial effects:

[0021] This invention provides an artificial corneal endothelial patch, which includes a main body and an extension portion. The main body is dome-shaped, and its outer diameter is greater than or equal to the diameter of the pupil. The extension portion has several portions, which are spaced apart on the outer periphery of the main body. The extension portion is an arc-shaped strip with the same curvature as the main body. The width of the extension portion gradually decreases along the direction away from the center point of the main body. A notch is formed between any two adjacent extension portions.

[0022] With the aforementioned dome-shaped main body, its convex sidewalls more closely resemble the shape of the corneal stroma, enabling effective adhesion and reducing deformation during the adhesion process. This lowers the elastic force of the main body, making it much less than the adsorption force generated by the liquid between the main body and the cornea. Consequently, the main body maintains the same shape as the cornea, improving adhesion stability. Furthermore, the notch between the extension portions facilitates deformation of the extension portions, aiding adhesion to the cornea and increasing the adsorption area between the artificial corneal endothelial graft and the cornea. This further enhances the adsorption force between the artificial corneal endothelial graft and the cornea, improving the stability of the artificial corneal endothelial graft.

[0023] By gradually decreasing the width of the extension portion away from the main body, firstly, during the attachment stage, the wider root of the extension portion near the main body provides a larger anchoring interface, enabling the central area of ​​the artificial corneal endothelial graft to form a high-density adhesion lattice on the cornea, enhancing the barrier effect against hydrostatic pressure of the aqueous humor; secondly, the root of the extension portion near the main body acts as a rigid anchor point, bearing the main load and inhibiting the overall displacement of the artificial corneal endothelial graft; thirdly, the narrower end of the extension portion away from the main body, through stress gradient reconstruction, enhances the overall attachment reliability, making the extension portion closer to the edge more prone to deformation, allowing for precise control of the microenvironment of the notch and the surrounding attachment dynamics, and with high flexibility, adapting to dynamic changes in the curvature of the corneal periphery (such as instantaneous deformation during eye movement), dissipating shear energy through local elastic deformation, and avoiding stress concentration at the edge of the notch; fourthly, the narrower end design reduces fluid resistance and prevents eddy currents from peeling off the edge of the artificial corneal endothelial graft.

[0024] Finally, no sutures are needed between the artificial corneal endothelial graft and the cornea, avoiding unnecessary damage. Attached Figure Description

[0025] To more clearly illustrate the technical solutions in the embodiments of the present invention, the accompanying drawings used in the description of the embodiments of the present invention will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on the content of the embodiments of the present invention and these drawings without creative effort.

[0026] Figure 1 This is a frontal view of an artificial corneal endothelial graft implanted into the eyeball in an embodiment of the present invention;

[0027] Figure 2 This is a cross-sectional view of the artificial corneal endothelial graft after implantation into the eyeball in an embodiment of the present invention;

[0028] Figure 3 This is a front view of the artificial corneal endothelial graft in an embodiment of the present invention;

[0029] Figure 4 This is a top view of the artificial corneal endothelial graft in an embodiment of the present invention;

[0030] Figure 5 It is the optical path diagram of a spherically designed artificial corneal endothelial graft;

[0031] Figure 6 This is the optical path diagram of the aspherical artificial corneal endothelial graft in this embodiment of the invention.

[0032] In the picture:

[0033] 1000, corneal stroma; 2000, pupil; 3000, anterior chamber;

[0034] 10. Artificial corneal endothelial graft;

[0035] 100, Main body; 200, Extension; 300, Notch; 400, Marking symbol. Detailed Implementation

[0036] Before explaining any implementation of this application in detail, it should be understood that this application is not limited to its application to the structural details and component arrangements set forth in the following description or shown in the above drawings.

[0037] In this application, the terms "comprising," "including," "having," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes that element.

[0038] In this application, the term "and / or" describes the relationship between related objects, indicating that three relationships can exist. For example, A and / or B can represent three cases: A existing alone, A and B existing simultaneously, and B existing alone. Additionally, the character " / " in this application generally indicates that the preceding and following related objects have an "and / or" relationship.

[0039] In this application, the terms "connection," "combination," "coupling," and "installation" can refer to direct connection, combination, coupling, or installation, or indirect connection, combination, coupling, or installation. For example, a direct connection refers to two parts or components being connected together without the need for an intermediary, while an indirect connection refers to two parts or components each being connected to at least one intermediary, with the connection achieved through the intermediary. Furthermore, "connection" and "coupling" are not limited to physical or mechanical connections or couplings, but can also include electrical connections or couplings.

[0040] In this application, those skilled in the art will understand that relative terms (e.g., “about,” “approximately,” “basically,” etc.) used in conjunction with quantities or conditions are to include the values ​​and have the meaning indicated by the context. For example, such relative terms include at least the degree of error associated with the measurement of a particular value, tolerances associated with the particular value due to manufacturing, assembly, use, etc. Such terms should also be considered as disclosing a range defined by the absolute values ​​of the two endpoints. Relative terms may refer to a certain percentage (e.g., 1%, 5%, 10% or more) of the indicated value. Numerical values ​​that do not use relative terms should also be disclosed as specific values ​​with tolerances. Furthermore, “basically” when expressing relative angular relationships (e.g., substantially parallel, substantially perpendicular) may refer to a certain degree (e.g., 1 degree, 5 degrees, 10 degrees or more) added to or subtracted from the indicated angle.

[0041] In this application, those skilled in the art will understand that the function performed by a component can be performed by one component, multiple components, one part, or multiple parts. Similarly, the function performed by a part can also be performed by one part, one component, or a combination of multiple parts.

[0042] In this application, the directional terms "upper," "lower," "left," "right," "front," and "rear" are used to describe the orientation and positional relationships shown in the accompanying drawings and should not be construed as limiting the embodiments of this application. Furthermore, in the context, it should be understood that when an element is mentioned as being connected "upper" or "lower" to another element, it can be directly connected to the other element "upper" or "lower," or indirectly connected through an intermediate element. It should also be understood that directional terms such as upper side, lower side, left side, right side, front side, and rear side not only represent positive orientation but can also be understood as lateral orientation. For example, "below" can include directly below, lower left, lower right, lower front, and lower rear.

[0043] like Figures 1 to 4 As shown, this embodiment provides an artificial corneal endothelial graft for implantation into the eyeball, such as... Figure 1The image shown is a frontal view of the notch-type artificial corneal endothelial graft 10 after implantation into the eyeball. During the procedure, the clinician first removes the Descemet's membrane and endothelium of the cornea, then creates a tunnel opening in the cornea using a puncture knife. The artificial corneal endothelial graft 10 is implanted through this tunnel opening. Figure 2 The image shown is a cross-sectional view of the notch-type artificial corneal endothelial graft 10 after implantation into the eyeball. The artificial corneal endothelial graft 10 is implanted into the anterior chamber 3000 through a tunnel opening, and its anterior surface should adhere to the corneal stroma layer 1000, rather than be suspended in the anterior chamber 3000. (Combined with...) Figure 3 and Figure 4 As shown, the artificial corneal endothelial patch 10 includes a main body 100 and an extension portion 200. The main body 100 is dome-shaped, and its outer diameter is greater than or equal to the diameter of the pupil 200. Several extension portions 200 are spaced apart on the outer periphery of the main body 100. Each extension portion 200 is an arc-shaped strip with the same curvature as the main body 100. The width of the extension portion 200 gradually decreases along a direction away from the center point of the main body 100. A notch 300 is formed between any two adjacent extension portions 200. The diameter of the pupil 200 is the maximum diameter within its variation range.

[0044] With the dome-shaped main body 100, its convex sidewalls are closer in shape to the corneal stroma 1000, enabling effective adhesion and reducing deformation during the adhesion process. This reduces the elastic force of the main body 100, making it much smaller than the adsorption force generated by the liquid between the main body 100 and the corneal stroma 1000. Consequently, the main body 100 maintains the same shape as the corneal stroma 1000, improving adhesion stability. Furthermore, the notch 300 between the extension portions 200 and 200 makes deformation of the extension portions 200 easier, facilitating adhesion to the corneal stroma 1000. This increases the adsorption area between the artificial corneal endothelial lamina 10 and the corneal stroma 1000, further enhancing the adsorption force between them and improving the stability of the artificial corneal endothelial lamina 10.

[0045] By utilizing the fact that the width of the extension portion 200 gradually decreases in the direction away from the main body portion 100, firstly, during the attachment stage, the wider root portion of the extension portion 200 near the main body portion 100 provides a larger anchoring interface, enabling the central area of ​​the artificial corneal endothelial patch 10 to form a high-density adhesion lattice on the corneal stroma layer 1000, thus enhancing the barrier effect against hydrostatic pressure of the aqueous humor; secondly, the root portion of the extension portion 200 near the main body portion 100 serves as a rigid anchor point, bearing the main load and suppressing the overall displacement of the artificial corneal endothelial patch 10; thirdly, the width of the extension portion 200 gradually decreases in the direction away from the main body portion 100. The narrower end of the 0 and the reduced size design enhance the overall adhesion reliability through stress gradient reconstruction, making the outer extension 200 closer to the edge more prone to deformation. It precisely controls the microenvironment of the notch 300 and the surrounding adhesion dynamics. With high flexibility, it adapts to the dynamic changes in the curvature of the corneal stroma 1000 (such as the instantaneous deformation when the eyeball rotates). It dissipates shear energy through local elastic deformation and avoids stress concentration at the edge of the notch 300. Fourthly, the narrower end design reduces fluid resistance and prevents eddy currents from peeling off the edge of the artificial corneal endothelial 10.

[0046] Finally, no sutures are needed between the artificial corneal endothelial graft 10 and the corneal stroma 1000 to avoid unnecessary damage.

[0047] In some embodiments, the thickness of the middle portion of the epitaxial portion 200 away from the notch 300 is greater than the thickness of the edge portion near the notch 300, in order to further reduce fluid resistance and improve adhesion stability. The thickness of the epitaxial portion 200 is the dimension of the epitaxial portion 200 along the light transmission direction.

[0048] The outer contour of the artificial corneal endothelial patch 10 is circular, the chord length of the notch 300 is L1, and the chord length of the end of the extension 200 away from the main body 100 is L2, where L1=L2.

[0049] Wherein, L1 refers to the circumferential span (opening width) of the notch 300 on the outermost periphery of the artificial corneal endothelial plexus 10, representing the circumference not covered by the artificial corneal endothelial plexus 10; while L2 refers to the circumferential span (width) of the extension 200 on the outermost periphery of the artificial corneal endothelial plexus 10, representing the circumference actually covered and adhered to by the artificial corneal endothelial plexus 10. Therefore, L1 and L2 together constitute the periodic unit of the outermost circumference of the artificial corneal endothelial plexus 10. The geometric setting of L1=L2 means that around the periphery of the artificial corneal endothelial plexus 10, the width of the extension 200 is exactly equal to the width of the adjacent notch 300. This precise 1:1 ratio has the following significance:

[0050] First aspect: Optimal balance in hydrodynamics. After implantation, the artificial corneal endothelial sheet 10 will be pressed against the corneal stromal layer 1000 by aqueous humor or air bubbles. The key first step for successful implantation lies in quickly and thoroughly discharging the fluid trapped under and around the artificial corneal endothelial sheet 10, especially viscoelastic agent, balanced salt solution or trapped air bubbles. L1, as the opening width of the notch 300, directly constitutes the channel for the fluid to escape to the periphery. When L1 = L2, the width of L1 is set to the minimum width required to maximize the drainage efficiency. If L1 is too small (i.e., L1 < L2), the fluid discharge speed will be greatly reduced, which may lead to an extended implantation time, and even incomplete adhesion due to fluid retention, eventually forming peripheral warping. On the contrary, if L1 is too large (i.e., L1 > L2), although the drainage is faster, L2 (the coverage width of the extension part 200) will be correspondingly reduced, sacrificing the sealing coverage rate of the peripheral interface. L1 = L2 ensures that the notch 300 provides a sufficiently spacious fluid discharge channel to ensure rapid adhesion in the early postoperative period. At the same time, it also maximally utilizes the peripheral coverage area represented by L2 to maintain the effective functional area of the artificial corneal endothelial sheet 10. This design improves the implantation success rate while maintaining the core function of the artificial corneal endothelial sheet 10.

[0051] Second aspect: Structural mechanics and the homogenization effect of peripheral stress. After successful implantation, the artificial corneal endothelial sheet 10 is continuously affected by the aqueous humor pressure. This pressure will attempt to push the artificial corneal endothelial sheet 10 away from the corneal stromal layer 1000, generating circumferential and radial tensile stresses at the periphery. L1 = L2 creates a highly symmetric and uniform periodic structure. This symmetry ensures that the geometric stiffness of the periphery of the artificial corneal endothelial sheet 10 is constant and predictable in the circumferential direction. The tensile or shear stress borne by each extension part 200 is balanced by the geometric compliance defined by the adjacent notch 300. If L1 and L2 are not equal, for example, if L2 is too large, the stiffness of the extension part 200 is too high, which may cause the edge of the extension part 200 to become a stress concentration point when under pressure and is more likely to warp; if L1 is too large, the width L2 of the extension part 200 is too small, and the structural integrity of the extension part 200 is damaged and is easily torn under tension. Through the setting of L1 = L2, the artificial corneal endothelial sheet 10, as a whole, has the smoothest stress distribution in the circumferential direction. This significantly improves the anti-detachment ability of the extension part 200 and the stability of the long-term structure, reducing the risk of peripheral endothelial dehiscence or displacement caused by uneven structural stress after surgery.

[0052] Among them, the number range of the notches 300 is 3 to 9, and the notches 300 are evenly distributed on the outer periphery of the main body part 100.

[0053] In this embodiment, the chord length L1 of the notch 300 is equal to the chord length L2 of the extension 200. After specifying the number n of notches 300, the outer diameter D1, and the inner diameter D2, the chord length L1 or L2 and the radius R of the notch 300 will be uniquely determined. D1 is the circumcircle diameter of the artificial corneal endothelial graft 10, and n is the number of notches 300. The notches 300 are arc-shaped, wherein... R is the radius of the notch 300, and D2 is the diameter of the circumcircle of the main body 100.

[0054] In the existing technology, Figure 5 The optical path diagram of the spherically designed artificial corneal endothelial patch 10. Because the spherically designed artificial corneal endothelial patch 10 uses a fixed spherical curvature, it is prone to aberrations. These aberrations can cause light focusing deviation, resulting in blurred edges, halos, or distortion in the image, directly affecting postoperative visual quality and causing visual discomfort to patients. To solve these problems, this embodiment uses an aspherical design to correct aberrations and improve postoperative visual quality for patients. Specifically, the main body 100 is an aspherical structure, as shown in the equation: Where c = 1 / R0, c is the vertex curvature of the aspherical surface, R0 is the vertex radius of curvature of the aspherical surface; k is the quadratic curve coefficient; r is the radial coordinate perpendicular to the optical axis; a i r 2i It is a high-order aspheric term. In some embodiments, the entire artificial corneal endothelial patch 10 is an aspheric design.

[0055] The optical path diagram of the aspheric-designed artificial corneal endothelial graft 10 is as follows: Figure 6 As shown, aspherical surfaces achieve spherical aberration correction through dynamic adjustment of surface curvature, with its core mechanism stemming from the precise compensation for optical defects in traditional spherical surfaces. By defining a continuously varying surface profile on the anterior or posterior surface of the artificial corneal endothelial graft 10 using even-order aspherical equations, the aspherical coefficients can dynamically adjust the local curvature at different radial positions. Specifically, as the radial distance r increases, the curvature of the aspherical surface gradually decreases (the local radius of curvature increases), precisely "weakening" the refraction angle of edge rays, while the central region of the main body 100 maintains approximately spherical refractive properties. This gradient change in curvature can counteract the inherent refractive deviation of the spherical surface, allowing incident rays from different heights to converge at the same image point, thereby physically eliminating spherical aberration and significantly improving image sharpness and contrast.

[0056] The surface of the corneal stroma 1000 is not an ideal plane, but rather has slight curvature variations and irregularities. Traditional, thicker artificial corneal endothelial grafts, due to their high bending stiffness, tend to maintain their geometric shape when pushed by aqueous humor bubbles. However, when encountering tiny depressions or bulges on the surface of the corneal stroma 1000, the edges of the rigid outer edge cannot completely adhere, easily forming tiny gaps or localized warping, the so-called "roof" effect. These gaps can not only become channels for aqueous humor leakage, compromising the barrier function of the artificial corneal endothelial graft, but may also lead to uneven distribution of adhesive forces, affecting the long-term stability of the artificial corneal endothelial graft.

[0057] Therefore, in this embodiment, the thickness of the epitaxial portion 200 gradually decreases along the direction away from the center point of the main body 100. After the epitaxial portion 200 becomes thinner, its shape more closely resembles a flexible thin film. Under the uniform pressure of the aqueous humor bubbles, the compliant thin epitaxial portion 200 can perfectly adapt to the microscopic geometry of the corneal stroma layer 1000 surface. This adaptive adhesion capability allows the edge of the epitaxial portion 200 to achieve maximum physical contact with the stroma layer, eliminating microscopic gaps and forming a near-perfect interface seal. This perfect adhesion not only improves waterproof performance, but more importantly, it evenly distributes the capillary forces or van der Waals forces required for adhesion across the entire contact surface, avoiding stress concentration and thus significantly enhancing the stability and resistance to detachment of the surrounding adhesion. Furthermore, the thinning design of the epitaxial portion 200 also reduces the mechanical interference of the implant on aqueous humor circulation, further promoting the physiological balance of the surrounding environment.

[0058] The convex side of the epitaxial portion 200 is at least partially frosted. The convex side of the epitaxial portion 200 is the anterior side, i.e., the surface that adheres to the corneal stroma 1000. The frosted surface is prepared through a frosting process. First, from the perspective of interfacial physicochemistry, the frosted surface creates a microscopically rough structure, significantly increasing the specific surface area of ​​the epitaxial portion 200. The generation of adhesive forces, whether van der Waals forces, capillary forces, or intermolecular forces such as hydrogen bonds, is directly proportional to the effective contact area between the two contact surfaces. The frosted surface formed by the frosting process has a large number of micron or nanometer-scale peak-valley structures, which can more effectively fill the irregular microstructure of the corneal stroma 1000 surface. This causes the actual effective contact area between the epitaxial portion 200 and the corneal stroma 1000 to increase geometrically, thereby significantly enhancing the interfacial bonding strength and providing a stronger initial adhesive force. Simultaneously, the rough microstructure surface has a higher surface free energy, which is beneficial for attracting and fixing water molecules and collagen fibers in the stroma layer at the interface.

[0059] Secondly, from the perspective of biomechanics and interfacial stability, the frosted surface plays a crucial role in preventing the extension portion 200 from detaching or displacing. The microstructure formed by the rough surface provides a mechanical interlocking effect. This mechanical interlocking provides additional shear strength for adhesion, making it difficult for the extension portion 200 to slide or separate along the interface when subjected to shear stress generated by aqueous humor erosion or micro-movements within the eye. Smooth surfaces, on the other hand, lack a mechanism to resist shear forces, and once the initial adhesive force is overcome, the extension portion 200 is prone to translation or dislocation. Furthermore, this micro-roughening mimics the adhesion characteristics of natural biological interfaces, which is more conducive to the dispersion and equalization of interfacial stress, effectively preventing stress concentration that leads to local detachment. This ensures rapid, durable, and stable peripheral adhesion of the artificial corneal endothelial graft 10 during the critical postoperative period, improving the success rate of the surgery.

[0060] The outer extension 200 is provided with a marking symbol 400 on the convex or concave side to facilitate the differentiation of the front and back sides of the artificial corneal endothelial graft 10, thereby improving surgical efficiency and accuracy.

[0061] Obviously, the above embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the implementation of the present invention. Those skilled in the art will be able to make various obvious changes, readjustments, and substitutions without departing from the scope of protection of the present invention. It is neither necessary nor possible to exhaustively describe all embodiments here. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention should be included within the scope of protection of the claims of the present invention.

Claims

1. An artificial corneal endothelial graft, characterized in that, include: The main body (100) is dome-shaped, and the outer diameter of the main body (100) is greater than or equal to the diameter of the pupil (2000); An extension portion (200) is provided, and the extension portions (200) are arranged at intervals on the outer periphery of the main body portion (100). The extension portions (200) are arc-shaped strips with the same curvature as the main body portion (100). The width of the extension portions (200) gradually decreases along the direction away from the center point of the main body portion (100). A notch (300) is formed between any two adjacent extension portions (200).

2. The artificial corneal endothelial graft according to claim 1, characterized in that, The outer contour of the artificial corneal endothelial patch (10) is circular, the chord length of the notch (300) is L1, and the chord length of the end of the extension (200) away from the main body (100) is L2, where L1=L2.

3. The artificial corneal endothelial graft according to claim 2, characterized in that, ， D1 is the circumscribed circle diameter of the artificial corneal endothelial graft, and n is the number of notches (300).

4. The artificial corneal endothelial graft according to claim 3, characterized in that, The notch (300) is arc-shaped, wherein, R is the radius of the notch (300), and D2 is the diameter of the circumcircle of the main body (100).

5. The artificial corneal endothelial graft according to any one of claims 1-4, characterized in that, The artificial corneal endothelial patch (10) is an aspherical structure, and its equation is: Where c = 1 / R0, c is the vertex curvature of the aspherical surface, R0 is the vertex radius of curvature of the aspherical surface; k is the quadratic curve coefficient; r is the radial coordinate perpendicular to the optical axis; a i r 2i It is a high-order non-spherical item.

6. The artificial corneal endothelial graft according to any one of claims 1-4, characterized in that, The thickness of the extension portion (200) gradually decreases along the direction away from the center point of the main body portion (100).

7. The artificial corneal endothelial graft according to any one of claims 1-4, characterized in that, The convex side of the extension (200) is at least partially frosted.

8. The artificial corneal endothelial graft according to claim 7, characterized in that, The frosted surface includes a peak-valley structure at the micron or nanometer level.

9. The artificial corneal endothelial graft according to any one of claims 1-4, characterized in that, The extension portion (200) is provided with a marking symbol (400) on the convex side or the concave side.

10. The artificial corneal endothelial graft according to any one of claims 1-4, characterized in that, The number of the notches (300) ranges from 3 to 9, and several of the notches (300) are evenly distributed on the outer periphery of the main body (100).

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