Controlled-release drug interventional therapy device adaptive to tumor local drug delivery

Abstract

The invention provides a controlled-release drug interventional therapy device adaptive to tumor local drug delivery, and relates to the field of medical instruments. The controlled-release drug interventional therapy device matched with tumor local drug delivery comprises a conveying cylinder, external threads are arranged on the two sides of the outer wall of the conveying cylinder, and the outer walls of the external threads are in threaded connection with positioning screw rings. According to the device, the servo motor provides stable and accurately-regulated driving force, the screw rod is driven to rotate, so that the threaded sleeve rod stably pushes the pressing disc, the rubber abutting block below the pressing disc is in close contact with the piston disc, the medicine pushing deviation caused by incompact contact is avoided, the pressure can be buffered, and the assembly can be protected; the pressing disc pushes the piston disc, the piston rod and the piston to stably move along the inner wall of the conveying cylinder, the moving distance of the piston can be accurately judged in cooperation with assistance of a positioning screw ring and scale marks, then the single-time or continuously-released dosage is accurately calculated and controlled, and the situation that the dosage is insufficient due to the problems of uneven manual operation force, experience judgment deviation and the like is effectively avoided.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of medical devices, in particular to a controllable drug release interventional therapy device suitable for local drug delivery of tumors. BACKGROUND

[0002] In the field of tumor treatment, systemic chemotherapy is difficult to accurately target lesions, easy to cause serious systemic toxic side effects and insufficient local drug concentration, resulting in limited efficacy. Therefore, local drug delivery combined with interventional therapy such as transvascular catheter has become an important development direction. By delivering drug-loaded components (such as microspheres, gels, stents or drug reservoirs) to the inside or peripheral area of tumor lesions, and relying on physical, chemical or biological mechanisms to release drugs, it can maintain high concentration of drugs in the tumor area to enhance the killing effect, and greatly reduce the side effects such as nausea and bone marrow suppression caused by drugs entering the systemic circulation. It can be adapted to different lesion types such as solid tumors (such as liver cancer, breast cancer) and luminal organ tumors (such as esophageal cancer, bile duct cancer).

[0003] However, the existing drug interventional therapy device suitable for local drug delivery of tumors has significant defects in drug amount controllability. Some devices rely too much on the operation experience of doctors, which is easy to cause insufficient drug release due to human judgment deviation, difficult to accurately set the single drug release amount according to the tumor size and treatment stage, unable to grasp the actual drug release situation, and difficult to dynamically adjust the drug amount according to the treatment progress or patient adverse reactions, affecting the accuracy and safety of treatment. SUMMARY

[0004] In view of the shortcomings of the prior art, the present application provides a controllable drug release interventional therapy device suitable for local drug delivery of tumors, which solves the problem of difficult drug release control.

[0005] To achieve the above purpose, the present application realizes the following technical scheme: The controllable drug release interventional therapy device suitable for local drug delivery of tumors comprises a delivery cylinder, external threads are formed on both sides of the outer wall of the delivery cylinder, a positioning screw ring is threadedly connected to the outer wall of the external threads, a handle is fixedly connected to one side of the outer wall of the delivery cylinder, an upper end of the handle is fixedly connected to a connecting rod, a storage groove is formed on the other side of the outer wall of the connecting rod, a screw rod is rotatably connected to the middle of the bottom surface and the top surface of the storage groove, a servo motor is fixedly connected to the upper end of the connecting rod, the output end of the servo motor penetrates the connecting rod to the inside of the storage groove and is fixedly connected to the upper end of the screw rod, a threaded sleeve rod is threadedly connected to the upper end of the outer wall of the screw rod, and a pressure plate is dampingly rotatably connected to the upper end of the threaded sleeve rod. The inner wall of the conveying cylinder is slidingly connected with a piston rod, the upper end of the piston rod is fixedly connected with a piston disc, the lower end of the piston rod is fixedly connected with a piston, the outer wall of the piston disc is fixedly connected with a stop disc, the lower end of the stop disc is in abutment with the upper end of the positioning screw ring, and the end of the stop disc is opposite to the length of the end of the piston. Through the above technical scheme, the servo motor provides stable and accurately controllable driving force to drive the screw rod to rotate to smoothly push the pressure plate, the rubber block under the pressure plate not only ensures close contact with the piston disc to avoid deviation of the medicine pushing caused by imperfect contact, but also buffers the pressure to protect the assembly, the pressure plate pushes the piston disc, the piston rod and the piston to stably move along the inner wall of the conveying cylinder, and the positioning screw ring and the scale line are matched to accurately judge the moving distance of the piston, thereby accurately calculating and controlling the medicine amount of single or continuous release, and effectively avoiding the problems of insufficient medicine amount caused by uneven manual operation force and experience deviation.

[0006] Further, the front end and the rear end of the outer wall of the conveying cylinder are provided with scale lines, and the positioning screw ring is opposite to the scale lines. Through the above technical scheme, the scale lines at the front end and the rear end of the outer wall of the conveying cylinder can provide quantitative position reference, and the positioning screw ring opposite to the scale lines can assist in judging the moving stroke of the piston rod driving the piston, and the scale lines can be combined to accurately calculate the medicine pushing amount, thereby providing intuitive quantitative basis for medicine control and reducing the deviation caused by relying on experience.

[0007] Further, the lower end of the conveying cylinder is threadedly connected with a catheter, the inside of the catheter is embedded with a superfine nickel-titanium alloy wire, and the head of the catheter is provided with a spherical medicine releasing port. Through the above technical scheme, the catheter threadedly connected with the lower end of the conveying cylinder is designed to facilitate replacement of catheters with different lengths or diameters according to the position of the tumor and the interventional path, thereby improving the adaptability of the device; the superfine nickel-titanium alloy wire embedded in the inside of the catheter can ensure the flexibility of the catheter to adapt to curved interventional paths such as blood vessels and cavities, while providing sufficient support to prevent the catheter from collapsing and blocking, thereby ensuring the smoothness of the medicine delivery channel; the spherical medicine releasing port at the head of the catheter can reduce the puncture damage to the tissue during intervention, while uniformly releasing the medicine from the spherical port to avoid excessive accumulation of the medicine in the local area to cause tissue irritation, thereby improving the safety of drug administration and the uniformity of drug distribution.

[0008] Further, the outer wall of the piston rod is slidingly connected with a cap, and the cap is threadedly connected with the upper end of the outer wall of the conveying cylinder. Through the above technical scheme, the cap slidingly connected with the outer wall of the piston rod and threadedly connected with the upper end of the conveying cylinder primarily seals the upper end opening of the conveying cylinder to prevent external dust, body fluid and other pollutants from entering the inside of the conveying cylinder to contaminate the medicine, while facilitating subsequent cleaning.

[0009] Furthermore, a control panel is provided at the lower end of the outer wall on one side of the grip bar, and the control panel is electrically connected to the servo motor; The above technical solution allows for easy control of the servo motor's on / off state via a control panel.

[0010] Furthermore, a charging port is provided at the upper end of the outer wall on one side of the grip; With the above technical solution, the charging interface can directly charge the device's built-in power supply, eliminating the need for frequent battery replacements, preventing the device from shutting down due to power depletion during surgery, and ensuring continuous and stable treatment.

[0011] Furthermore, a protective shell is fixedly connected to the upper end of the connecting rod, and the top of the protective shell is fixedly connected to the upper end of the servo motor. Through the above technical solutions, the protective shell prevents damage to the motor caused by collisions with external instruments, splashes of bodily fluids, or dust adhesion during surgery, and prevents the motor from malfunctioning due to external interference.

[0012] Furthermore, a plurality of rubber blocks are fixedly connected to one side of the lower surface of the pressure plate, and the lower end of the rubber blocks abuts against the upper end of the piston plate; Through the above technical solution, multiple rubber blocks on the lower surface of the pressure plate abut against the piston plate. By utilizing the elastic properties of the rubber material, a tight contact can be formed between the pressure plate and the piston plate, avoiding uneven pressure transmission due to gaps between the two. This ensures that the thrust of the pressure plate can be stably transmitted to the piston plate, thereby driving the piston to move smoothly.

[0013] This invention provides a controlled-release drug delivery device adapted for local tumor administration. It offers the following advantages: This invention provides a controlled-release drug delivery interventional therapy device adapted for local tumor administration. A servo motor provides a stable and precisely adjustable driving force, which drives the screw to rotate and the threaded sleeve to smoothly push the pressure plate. The rubber block under the pressure plate ensures close contact with the piston plate, avoiding drug delivery deviation due to poor contact, and also buffers the pressure protection components. The pressure plate pushes the piston plate, piston rod, and piston to move stably along the inner wall of the delivery cylinder. With the assistance of the positioning screw ring and scale lines, the piston movement distance can be accurately judged, thereby accurately calculating and controlling the amount of drug released in a single or continuous manner, effectively avoiding insufficient drug dosage caused by uneven manual operation force and experience judgment deviation. Attached Figure Description

[0014] Figure 1 This is an isometric schematic diagram of the present invention; Figure 2 This is a schematic diagram of the motion of the present invention; Figure 3 This is an exploded schematic diagram of the piston rod in this invention; Figure 4This is a schematic axial section of the connecting rod in this invention; Figure 5 This is a bottom view of the present invention; Figure 6 For the present invention Figure 4 Enlarged view of point A in the middle.

[0015] In the picture: 1. Conveying cylinder; 11. External thread; 12. Scale line; 13. Positioning screw ring; 14. Guide tube; 15. Piston rod; 16. Piston disc; 17. Piston; 18. Abutment plate; 19. Cap; 2. Handle rod; 21. Control panel; 22. Charging interface; 23. Connecting rod; 24. Storage slot; 25. Screw; 26. Protective shell; 27. Servo motor; 28. Threaded sleeve rod; 29. ​​Pressure plate; 210. Rubber abutment block. Detailed Implementation

[0016] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0017] Example: like Figures 1-6 As shown, this embodiment of the invention provides a controlled-release drug interventional therapy device adapted for local tumor administration, including a delivery cylinder 1. External threads 11 are provided on both sides of the outer wall of the delivery cylinder 1. A positioning screw ring 13 is threadedly connected to the outer wall of the external threads 11. A handle 2 is fixedly connected to one side of the outer wall of the delivery cylinder 1. A connecting rod 23 is fixedly connected to the upper end of the handle 2. A storage groove 24 is provided on the other side of the outer wall of the connecting rod 23. A screw 25 is rotatably connected to the middle of the bottom and top surfaces of the storage groove 24. A servo motor 27 is fixedly connected to the upper end of the connecting rod 23. The output end of the servo motor 27 passes through the connecting rod 23 to the interior of the storage groove 24 and is fixedly connected to the upper end of the screw 25. A threaded sleeve 28 is threadedly connected to the upper end of the outer wall of the screw 25. A pressure plate 29 is damped and rotatably connected to the upper end of the threaded sleeve 28. A piston rod 15 is slidably connected to the inner wall of the conveying cylinder 1. A piston disc 16 is fixedly connected to the upper end of the piston rod 15. A piston 17 is fixedly connected to the lower end of the piston rod 15. A stop disc 18 is fixedly connected to the outer wall of the piston disc 16. The lower end of the stop disc 18 abuts against the upper end of the positioning screw ring 13. The end of the stop disc 18 is symmetrical in length to the end of the piston 17. The servo motor 27 provides a stable and precisely adjustable driving force, which drives the screw 25 to rotate, causing the threaded sleeve 28 to smoothly push the pressure plate 29. The rubber block 210 under the pressure plate 29 ensures close contact with the piston plate 16, avoiding deviations in drug delivery due to poor contact, and also buffers the pressure protection components. The pressure plate 29 pushes the piston plate 16, piston rod 15 and piston 17 to move stably along the inner wall of the delivery cylinder 1. With the assistance of the positioning screw ring 13 and the scale line 12, the movement distance of the piston 17 can be accurately judged, thereby accurately calculating and controlling the amount of drug released in a single or continuous manner, effectively avoiding insufficient drug delivery caused by uneven manual operation force and experience judgment deviation.

[0018] The front and rear ends of the outer wall of the conveying cylinder 1 are provided with scale lines 12, and the positioning screw ring 13 is opposite to the scale lines 12; The scale lines 12 on the front and rear ends of the outer wall of the delivery cylinder 1 can provide a quantitative position reference, while the positioning screw ring 13 opposite to the scale line 12 can help determine the movement stroke of the piston rod 15 driving the piston 17. Combined with the scale, the amount of drug pushed can be accurately calculated, providing an intuitive quantitative basis for drug dosage control and reducing the deviation of relying solely on experience.

[0019] The lower end of the delivery cylinder 1 is threadedly connected to a conduit 14, the inside of which is embedded an ultra-fine nickel-titanium alloy wire, and the head of the conduit 14 is provided with a spherical drug release port. The design of the catheter 14, which is threaded at the lower end of the delivery tube 1, facilitates the replacement of catheters 14 of different lengths or diameters according to the tumor location and interventional path, thereby improving the adaptability of the device. The ultra-fine nickel-titanium alloy wire embedded inside the catheter 14 can provide sufficient support to prevent the catheter 14 from collapsing and becoming blocked, while ensuring the flexibility of the catheter 14 to adapt to the curved interventional path of blood vessels and cavities, thus ensuring the smooth flow of drugs. The spherical drug release port at the tip of the catheter 14 can reduce puncture damage to tissues during intervention, while allowing the drug to be released evenly from the spherical port, avoiding excessive accumulation of drugs in the local area and causing tissue irritation, thereby improving the safety of drug administration and the uniformity of drug distribution.

[0020] A cap 19 is slidably connected to the outer wall of the piston rod 15, and the cap 19 is threadedly connected to the upper end of the outer wall of the conveying cylinder 1. The cap 19, which is slidably connected to the outer wall of the piston rod 15 and threaded to the upper end of the conveying cylinder 1, primarily functions to seal the upper opening of the conveying cylinder 1, preventing external dust, body fluids, and other contaminants from entering the conveying cylinder 1 and contaminating the medicine, while also facilitating subsequent cleaning.

[0021] A control panel 21 is provided at the lower end of the outer wall on one side of the grip bar 2. The control panel 21 is electrically connected to the servo motor 27. The servo motor 27 can be easily switched on and off via the control panel 21.

[0022] A charging port 22 is provided at the upper end of the outer wall on one side of the grip 2; The charging port 22 can directly charge the device's built-in power supply, eliminating the need for frequent battery replacements and preventing the device from shutting down due to power depletion during surgery, thus ensuring continuous and stable treatment.

[0023] A protective shell 26 is fixedly connected to the upper end of the connecting rod 23, and the top of the protective shell 26 is fixedly connected to the upper end of the servo motor 27. The protective shell 26 prevents damage to the motor caused by collisions with external instruments, splashes of bodily fluids, or dust during surgery, and prevents the motor from malfunctioning due to external interference.

[0024] Multiple rubber blocks 210 are fixedly connected to one side of the lower surface of the pressure plate 29, and the lower end of the rubber blocks 210 abuts against the upper end of the piston plate 16. Multiple rubber blocks 210 on the lower surface of the pressure plate 29 abut against the piston plate 16. By utilizing the elastic properties of the rubber material, the pressure plate 29 and the piston plate 16 can form a tight contact, avoiding uneven pressure transmission due to gaps between them. This ensures that the thrust of the pressure plate 29 can be stably transmitted to the piston plate 16, thereby driving the piston 17 to move smoothly.

[0025] Working principle: Before use, the device is powered by the charging interface 22 on the handle 2. The piston 17 is manually pulled to draw up the drug. Then, a catheter 14 of appropriate length or diameter is selected according to the tumor intervention path and connected to the lower end of the delivery cylinder 1 by thread. During operation, the doctor holds the handle 2 and adjusts the position of the positioning screw ring 13 according to the required drug amount based on the scale line 12 on the outer wall of the delivery cylinder 1 to determine the drug release amount. Then, the servo motor 27 is started through the control panel 21 on the handle 2. The servo motor 27 outputs power to drive the screw 2 in the storage slot 24 of the connecting rod 23. 5. Rotation of the screw 25 drives the threaded sleeve 28 connected to the outer wall thread to move down, thereby pushing the pressure plate 29 at the upper end of the threaded sleeve 28. The rubber block 210 on the lower surface of the pressure plate 29 makes close contact with the piston plate 16 by means of its elasticity and transmits the thrust, causing the piston plate 16 to drive the piston rod 15 and the piston 17 at the lower end to move down smoothly along the inner wall of the delivery cylinder 1. The piston 17 squeezes the drug in the delivery cylinder 1 until it abuts against the positioning screw ring 13. The drug is delivered along the catheter 14 at the lower end of the delivery cylinder 1 and finally accurately released to the tumor site from the spherical drug release port at the head of the catheter 14.

[0026] The following points should be noted in this article: 1. The accompanying drawings of the embodiments disclosed herein only relate to the structures involved in the embodiments disclosed herein; other structures can be referred to in a general design.

[0027] 2. Where there is no conflict, the embodiments of this disclosure and the features in the embodiments can be combined with each other to obtain new embodiments.

[0028] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

Claims

1. A controlled-release drug delivery device adapted for local tumor administration, comprising a delivery tube (1), characterized in that: Both sides of the outer wall of the conveying cylinder (1) are provided with external threads (11). The outer wall of the external threads (11) is threaded with a positioning screw ring (13). A handle (2) is fixedly connected to one side of the outer wall of the conveying cylinder (1). A connecting rod (23) is fixedly connected to the upper end of the handle (2). A storage groove (24) is provided on the other side of the outer wall of the connecting rod (23). A screw (25) is rotatably connected to the middle of the bottom and top surfaces of the storage groove (24). A servo motor (27) is fixedly connected to the upper end of the connecting rod (23). The output end of the servo motor (27) passes through the connecting rod (23) to the inside of the storage groove (24) and is fixedly connected to the upper end of the screw (25). A threaded sleeve (28) is threadedly connected to the upper end of the outer wall of the screw (25). A pressure plate (29) is damped and rotatably connected to the upper end of the threaded sleeve (28). A piston rod (15) is slidably connected to the inner wall of the conveying cylinder (1). A piston disc (16) is fixedly connected to the upper end of the piston rod (15). A piston (17) is fixedly connected to the lower end of the piston rod (15). A stop disc (18) is fixedly connected to the outer wall of the piston disc (16). The lower end of the stop disc (18) abuts against the upper end of the positioning screw ring (13). The end of the stop disc (18) is symmetrical in length to the end of the piston (17).

2. The controlled-release drug delivery interventional therapy device adapted for local tumor administration according to claim 1, characterized in that: The front and rear ends of the outer wall of the conveying cylinder (1) are provided with scale lines (12), and the positioning screw ring (13) is opposite to the scale lines (12).

3. The controlled-release drug delivery interventional therapy device adapted for local tumor administration according to claim 1, characterized in that: The lower end of the delivery cylinder (1) is threaded with a conduit (14), the conduit (14) is embedded with an ultra-fine nickel-titanium alloy wire, and the head of the conduit (14) is provided with a spherical drug release port.

4. The controlled-release drug delivery interventional therapy device adapted for local tumor administration according to claim 1, characterized in that: The piston rod (15) is slidably connected to a cap (19) on its outer wall, and the cap (19) is threadedly connected to the upper end of the outer wall of the conveying cylinder (1).

5. The controlled-release drug delivery interventional therapy device adapted for local tumor administration according to claim 1, characterized in that: A control panel (21) is provided at the lower end of the outer wall of one side of the grip (2), and the control panel (21) is electrically connected to the servo motor (27).

6. The controlled-release drug delivery interventional therapy device adapted for local tumor administration according to claim 1, characterized in that: A charging port (22) is provided on the upper end of the outer wall of one side of the grip (2).

7. The controlled-release drug delivery interventional therapy device adapted for local tumor administration according to claim 1, characterized in that: The upper end of the connecting rod (23) is fixedly connected to a protective shell (26), and the top of the protective shell (26) is fixedly connected to the upper end of the servo motor (27).

8. The controlled-release drug delivery interventional therapy device adapted for local tumor administration according to claim 1, characterized in that: A plurality of rubber blocks (210) are fixedly connected to one side of the lower surface of the pressure plate (29), and the lower end of the rubber blocks (210) abuts against the upper end of the piston plate (16).

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