Composition with soothing and repairing effects as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of cosmetics, and particularly relates to a composition with soothing and repairing effects and a preparation method and application thereof.The composition with the soothing and repairing effects is prepared from, by weight, 0.5%-4.0% of humulus lupulus extract, 0.5%-4.0% of humulus lupulus extract, 0.5%-4.0% of humulus lupulus extract, 0.5%-4.0% of humulus lupulus extract and the balance water. And 0.1%-2.0% of a Velcro root extract. According to the technical scheme, the humulus lupulus extract, the magic claw root extract and the ceramide are scientifically compounded, so that a multi-channel synergistic effect is realized, and the soothing and repairing effects are effectively improved.

Description

Technical Field

[0001] This invention relates to a composition with soothing and repairing effects, its preparation method and application, belonging to the field of cosmetic technology. Background Technology

[0002] Sensitive skin typically manifests as persistent or intermittent redness, dryness, burning, or stinging, severely impacting consumers' skin health. Therefore, there is an urgent market demand for skincare products with highly effective soothing, moisturizing, and barrier-repairing functions.

[0003] Currently, the active ingredients used in cosmetics for soothing and anti-allergy purposes are mostly concentrated in areas such as bisabolol, gentian extract, and various ceramides. While these ingredients have some effect, related products in the market are highly homogenized. More importantly, existing technological solutions for addressing skin sensitivity often focus solely on anti-inflammation or repairing the physical barrier, lacking the targeted and comprehensive ability to address complex sensitivity conditions such as deep stinging and neurogenic redness. This results in many products providing only temporary surface relief, failing to achieve long-term repair and stabilization through multiple pathways and at the root cause.

[0004] Therefore, there is an urgent need in this field to develop a novel technical solution that can synergistically act on multiple key pathways related to skin sensitivity (such as immune-inflammatory pathways and neurosensory pathways) to achieve faster and more comprehensive intervention and repair of complex sensitivity symptoms such as skin redness and stinging, thereby making up for the shortcomings of existing technologies. Summary of the Invention

[0005] This invention addresses the shortcomings of existing technologies by providing a composition with soothing and repairing effects, its preparation method, and its application. This composition can inhibit inflammatory responses through both immune and neural pathways, rapidly relieving skin redness, stinging, and other discomforts, while simultaneously repairing the skin barrier.

[0006] The technical solution of the present invention to solve the above-mentioned technical problems is as follows: One objective of this invention is to provide a composition with soothing and repairing effects, comprising the following active ingredients by weight percentage: Hops ( Humulus lupulus L.) extract 0.5%–4.0%; Root extract of *Harpagophytum procumbens*, 0.1%–2.0%.

[0007] The above-mentioned technical solution of the present invention achieves multi-pathway synergistic effect through the scientific combination of hop extract, devil's claw root extract and ceramide, effectively improving the soothing and repairing effect.

[0008] Among them, hop extract is rich in α-acids such as humulone, which has significant anti-inflammatory activity and can effectively inhibit the production of pro-inflammatory mediators (such as TNF-α, IL-6), blocking the inflammatory cascade from the source of immunity, thereby reducing the inflammatory response of the skin and providing a rapid redness reduction effect; the harpain component in devil's claw root extract can effectively inhibit COX-2 (cyclooxygenase-2) activity, thereby reducing the synthesis of inflammatory factors such as prostaglandins, strongly blocking the inflammatory pathway, and can also act on the nerve perception pathway, quickly relieving the stinging sensation of the skin by regulating the sensitivity of nerve endings; the combination of the two forms a "immune-neural" dual inhibitory closed loop, with hop inhibiting the initiation of inflammatory signals from the upstream, and devil's claw inhibiting the synthesis of inflammatory mediators and soothing nerves from the downstream, together achieving comprehensive, multi-target deep soothing, quickly relieving discomfort such as redness, stinging, and burning, overcoming the shortcomings of existing technologies where single ingredients or simple combinations are insufficient in terms of specificity and comprehensive effect when solving complex sensitivity problems.

[0009] Furthermore, by weight percentage, it also includes the following components: Purified water 70%–90%; Glycerin 5%–10%; 1,3-Butanediol 5%–10%; D-Panthenol 1%–5%; Ceramides 0.6%–1.0%; A copolymer of ammonium acryloyl dimethyl taurate / vinylpyrrolidone (also known as ammonium acryloyl dimethyl taurate / VP copolymer) 0.1%–0.6%; Polyacrylate crosspolymer-6 0.1%~0.6%; Sodium hyaluronate 0.1%–1%; Polydimethylsiloxane 0.1%–1%; Capryloyl hydroxamic acid 0.1%–0.8%; p-Hydroxyacetophenone 0.1%–0.6%.

[0010] Furthermore, the active ingredient in the hops extract includes humulone; the active ingredient in the devil's claw root extract includes harpaquinone.

[0011] A second objective of this invention is to provide a method for preparing the composition described above, comprising the following steps: S1. Mix purified water, ammonium acryloyl dimethyl taurate / vinylpyrrolidone copolymer, polyacrylate crosspolymer-6, glycerol, 1,3-butanediol, D-panthenol, sodium hyaluronate and polydimethylsiloxane, and heat and stir until completely dissolved and homogeneous. S2. Homogenize and stir; S3. Cool, add hop extract, devil's claw root extract, ceramide, capryloyl hydroxamic acid and p-hydroxyacetophenone, and stir well; S4. Cool to room temperature, discharge, and the product is ready.

[0012] Furthermore, in step S1, the temperature is raised to 70–90°C.

[0013] Furthermore, in step S2, the temperature is maintained at 70–90°C, and the stirring time is 5–20 minutes.

[0014] Furthermore, in step S3, the temperature is cooled to 40–50°C.

[0015] A third objective of this invention is to provide the use of the composition described above in the preparation of cosmetics for soothing, repairing the skin barrier, and reducing skin redness and / or stinging.

[0016] Furthermore, the cosmetic product is a serum, lotion, cream, or mask.

[0017] Furthermore, the cosmetic product is a serum.

[0018] Compared with the prior art, the present invention has the following beneficial effects: 1. Significant Synergistic Effect: This invention is the first to combine hop extract and devil's claw root extract, discovering a significant synergistic effect between the two in soothing and anti-inflammatory aspects. Hop extract (rich in humulone) can inhibit the production of pro-inflammatory mediators such as TNF-α and IL-6 from upstream, blocking the immune-inflammatory cascade; devil's claw root extract (rich in harpacoside) can effectively inhibit COX-2 activity from downstream, reducing the synthesis of inflammatory mediators such as prostaglandins, and can act on nerve endings to alleviate tingling sensation. The two form a "immune-neural" dual inhibitory closed loop, achieving comprehensive and multi-target deep soothing, with effects superior to the simple superposition of single ingredients. Ceramides, as an important component of the skin barrier, can replenish lipids lost in the stratum corneum, enhance the integrity of the skin barrier and its ability to resist external stimuli, reduce moisture loss, and improve dry skin. The synergistic effect of the three not only inhibits inflammation through both immune and neurological pathways, quickly relieving discomfort symptoms such as skin redness and tingling, but also simultaneously repairs the damaged skin barrier, achieving long-term repair and stabilization of sensitive skin.

[0019] 2. Comprehensive efficacy: This composition not only provides powerful soothing, but also, through the combination of ingredients such as ceramides, panthenol, and sodium hyaluronate, it can simultaneously achieve three major functions: "soothing, moisturizing, and repairing," addressing both the symptoms and the root cause, and fundamentally improving skin health and tolerance.

[0020] 3. Safe and gentle: The core active ingredients are all derived from natural plant extracts, which are gentle and non-irritating, and suitable for sensitive skin.

[0021] 4. Simple preparation process: The preparation method provided by this invention has simple steps, easy-to-control conditions, and is suitable for large-scale production. Detailed Implementation

[0022] The principles and features of the present invention are described below. The examples given are only for explaining the present invention and are not intended to limit the scope of the present invention.

[0023] The hop extract and devil's claw root extract described in this invention are both commercially available or prepared using conventional plant extraction processes in the field (such as water extraction and alcohol extraction). The ceramide can be common types such as ceramide NP and ceramide EOP.

[0024] Example 1 This embodiment provides a serum with soothing and repairing effects, the formula of which includes the following components by weight percentage: Hops extract: 2.0%; Devil's claw root extract: 1.2%; Ceramide NP: 0.6%; Sodium hyaluronate: 0.15%; Glycerin: 5.0%; D-Panthenol: 2.0%; 1,3-Butanediol: 5.0%; Polyacrylate crosspolymer-6: 0.3%; Acryloyldimethyl taurate ammonium / VP copolymer: 0.5%; Polydimethylsiloxane: 0.8%; Capryloyl hydroxamic acid: 0.3%; p-Hydroxyacetophenone: 0.4%; Deionized water: Add to 100%.

[0025] Preparation method: (1) Add deionized water, ammonium acryloyl dimethyl taurate / VP copolymer, polyacrylate crosspolymer-6, glycerol, part of 1,3-butanediol, D-panthenol, sodium hyaluronate and polydimethylsiloxane to the main pot, heat to 80°C, and stir at 100 rpm until all components are completely dissolved and the system is homogeneous.

[0026] (2) Switch to a high-speed homogenizer and homogenize at 80°C and 130 rpm for 10 minutes to form a uniform base material.

[0027] (3) When the material is cooled to 45°C, add hop extract, devil's claw root extract, ceramide NP, capryloyl hydroxamic acid, p-hydroxyacetophenone and the remaining 1,3-butanediol, and continue stirring until the mixture is uniform.

[0028] (4) Continue stirring and cooling to below 30°C, then discharge the material to obtain the essence with soothing and repairing effects.

[0029] Example 2 This embodiment provides a serum with soothing and repairing effects, the formula of which includes the following components by weight percentage: Hops extract: 3.0%; Devil's claw root extract: 0.8%; Ceramide NP: 0.8%; Sodium hyaluronate: 0.18%; Glycerin: 6.0%; D-Panthenol: 1.0%; 1,3-Butanediol: 5.0%; Polyacrylate crosspolymer-6: 0.4%; Acryloyldimethyl taurate ammonium / VP copolymer: 0.5%; Polydimethylsiloxane: 0.8%; Capryloyl hydroxamic acid: 0.3%; p-Hydroxyacetophenone: 0.4%; Deionized water: Add to 100%.

[0030] The preparation process in this embodiment is the same as in Example 1, except that the ratio of hop extract and devil's claw root extract was adjusted.

[0031] Example 3 This embodiment provides a serum with soothing and repairing effects, the formula of which includes the following components by weight percentage: Hops extract: 1.0%; Devil's claw root extract: 1.5%; Ceramide NP: 0.6%; Sodium hyaluronate: 0.1%; Glycerin: 6.0%; D-Panthenol: 1.0%; 1,3-Butanediol: 7.0%; Polyacrylate crosslinker-6: 0.25%; Ammonium acryloyldimethyltaurate / VP copolymer: 0.45%; Polydimethylsiloxane: 1.2%; Capryloyl hydroxamic acid: 0.3%; p-Hydroxyacetophenone: 0.4%; Deionized water: Add to 100%.

[0032] The preparation process in this embodiment is the same as in Example 1, except that the ratio of hop extract and devil's claw root extract was adjusted.

[0033] Comparative Example 1 The formula is basically the same as that in Example 1, except that hop extract is not added.

[0034] Comparative Example 2 The formula is basically the same as that in Example 1, except that devil's claw root extract is not added.

[0035] Comparative Example 3 The formula is basically the same as that in Example 1, except that hop extract and devil's claw root extract are not added.

[0036] Efficacy evaluation: To verify the efficacy of the composition of this invention, 60 volunteers with sensitive skin and fragile skin barrier (TEWL value > 15g / hm) were recruited. 2 The subjects were divided into 6 groups on average. Using a self-comparison method, each group used the essence prepared in Examples 1-3 and Comparative Examples 1-3 in the morning and evening for 14 consecutive days. Relevant skin indicators were measured before use (D0) and after use (D14).

[0037] I. Test Steps: 1. Before sample use (D0) (1) Cleanse face and wait: Subjects cleanse their face with facial cleanser and dry their skin with dry facial tissue. They sit quietly for 30 minutes in a laboratory at a temperature of 21±1℃ and 50±10%RH. (2) Testing: Laboratory personnel measured and recorded the subject's skin stratum corneum moisture content, transepidermal water loss (TEWL) value, skin color a* value, and skin red pigment value; (3) Sample distribution and use: Laboratory personnel instruct subjects on how to use the samples and distribute test samples.

[0038] 2. Samples were used 14 days later (D14). (1) Cleanse face and wait: Subjects cleanse their face with facial cleanser and dry their skin with a dry facial tissue. They sit quietly for 30 minutes in a laboratory at a temperature of 21±1℃ and 50±10%RH. (2) Testing: Laboratory personnel measured and recorded the subject’s skin stratum corneum moisture content, transepidermal water loss (TEWL) value, skin color (a*) value, and skin red pigment value.

[0039] II. The instruments used in the experiment are shown in Table 1.

[0040] Table 1 Test Instrument Item List

[0041] III. The results of the skin stratum corneum moisture content test are shown in Table 2.

[0042] Table 2. Data on the moisture content of the stratum corneum of the skin.

[0043] As shown in Table 2 above, after 14 days of continuous use of the serum product of this invention, the water content of the stratum corneum of the facial skin of the subjects increased compared with the initial value, and the increase was significant (p < 0.05). Therefore, this invention can significantly improve the water content of the stratum corneum and has a moisturizing effect.

[0044] IV. The results of the transepidermal water loss (TEWL) value test are shown in Table 3.

[0045] Table 3. Transepidermal water loss (TEWL) data (unit: g / hm) 2 )

[0046] As shown in Table 3 above, after 14 days of continuous use of the serum product of this invention, the transepidermal water loss (TEWL) value of the subjects' faces decreased compared with the initial value, and the decrease was statistically significant (p < 0.05). Therefore, this invention can significantly reduce the transepidermal water loss (TEWL) value of the skin, and has the effects of reducing skin moisture loss and repairing the skin barrier.

[0047] V. The results of the skin color a* value test are shown in Table 4.

[0048] Table 4 Skin Color a* Value Data Table

[0049] As shown in Table 4 above, after 14 days of continuous use of the serum product of this invention, the a* value of the subjects' facial skin color decreased compared with the initial value, and the decrease was significant (p < 0.05). This indicates that the present invention can significantly reduce the a* value of skin color, meaning it can alleviate skin redness.

[0050] VI. The results of the skin red pigment value test are shown in Table 5.

[0051] Table 5. Skin Hemogen Value Data Table

[0052] As shown in Table 5 above, after 14 days of continuous use of the serum product of this invention, the facial skin redness value of the subjects decreased compared with the initial value, and the decrease was statistically significant (p < 0.05). Therefore, this invention can significantly reduce skin redness value and alleviate skin redness.

[0053] Explanation of Tables 2-5: 1. The formula for calculating the rate of change is: Rate of change (= D14 mean) (mean of D0) / mean of D0 × 100%.

[0054] 2. P value: Generally, P > 0.05 indicates no significant difference, P < 0.05 indicates a statistically significant difference, and P < 0.01 indicates a highly statistically significant difference.

[0055] 3. Difference analysis: Based on the P value, "no significant difference (P>0.05)", "statistically significant difference (P<0.05)", and "extremely significant difference (P<0.01)".

[0056] The experimental results showed that Examples 1 to 3 were all compound systems of hop extract and devil's claw root extract, and the efficacy gradually increased with the optimization of the ratio.

[0057] Example 1 (basic compound ratio): After 14 days of use, the stratum corneum moisture content increased by 9.74%, the TEWL value decreased by 12.66%, and the a* value and red pigment value decreased by 3.14% and 5.37% respectively. All indicators showed significant differences (p<0.05), achieving the basic effects of moisturizing, repairing the skin barrier, and soothing redness. Examples 2 and 3 (optimized compound ratio) showed better efficacy, with a moisture content increase rate of 13.71%-14.80%, a TEWL value decrease rate of 20.71%-23.91%, and a redness-related index (a* value, red pigment value) decrease rate of 5.80%-12.46%, all of which reached extremely significant differences (p<0.01), confirming that after optimizing the compound ratio of the core ingredients, the synergistic effect was further enhanced and the efficacy was more significant.

[0058] The efficacy change rates of Comparative Example 1 (containing only hops extract) and Comparative Example 2 (containing only devil's claw root extract) were all less than 6%. Among them, the moisture content increased by 4.53%-5.27%, the TEWL value decreased by 4.98%-5.87%, and the redness index decreased by 0.32%-2.69%. Moreover, the P values ​​of all indicators were >0.05, indicating no statistical difference, which shows that a single ingredient is difficult to achieve ideal skin care effects.

[0059] The skin indicators of Comparative Example 3 (without core extract) showed almost no change, with the highest change rate being only 1.49%, further confirming that the combination of hop extract and devil's claw root extract is the key to efficacy.

[0060] In terms of safety, no adverse reactions were observed in any of the subjects during continuous use of the products in each embodiment, indicating that the products are safe and non-irritating.

[0061] In summary, the combination of hop extract and devil's claw root extract of this invention has excellent moisturizing, skin barrier repair and redness soothing effects. After optimization of the ratio (Examples 2 and 3), the effects are more significant. The comparative group highlights the necessity of the synergistic effect of the combination. This product is especially suitable for people with sensitive skin and fragile skin barriers and has extremely high application value.

[0062] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A composition having soothing and repairing effects, characterized in that, By weight percentage, it contains the following active ingredients: Hops extract 0.5%–4.0%; Devil's claw root extract 0.1%–2.0%.

2. The composition with soothing and repairing effects according to claim 1, characterized in that, It also includes the following components by weight percentage: Purified water 70%–90%; Glycerin 5%–10%; 1,3-Butanediol 5%–10%; D-Panthenol 1%–5%; Ceramides 0.6%–1.0%; Copolymer of ammonium acryloyldimethyl taurate / vinylpyrrolidone: 0.1%–0.6%; Polyacrylate crosspolymer-6 0.1%~0.6%; Sodium hyaluronate 0.1%–1%; Polydimethylsiloxane 0.1%–1%; Capryloyl hydroxamic acid 0.1%–0.8%; p-Hydroxyacetophenone 0.1%–0.6%.

3. The composition with soothing and repairing effects according to claim 1 or 2, characterized in that, The active ingredient in the hop extract includes humulone; the active ingredient in the devil's claw root extract includes harpain.

4. A method for preparing the composition according to any one of claims 1 to 3, characterized in that, Includes the following steps: S1. Mix purified water, ammonium acryloyl dimethyl taurate / vinylpyrrolidone copolymer, polyacrylate crosspolymer-6, glycerol, 1,3-butanediol, D-panthenol, sodium hyaluronate and polydimethylsiloxane, and heat and stir until completely dissolved and homogeneous. S2. Homogenize and stir; S3. Cool, add hop extract, devil's claw root extract, ceramide, capryloyl hydroxamic acid and p-hydroxyacetophenone, and stir well; S4. Cool to room temperature, discharge, and the product is ready.

5. The preparation method according to claim 4, characterized in that, In step S1, the temperature is heated to 70–90°C.

6. The preparation method according to claim 4, characterized in that, In step S2, the temperature is maintained at 70-90℃, and the stirring time is 5-20 minutes.

7. The preparation method according to claim 4, characterized in that, In step S3, the temperature is cooled to 40–50°C.

8. The use of a composition according to any one of claims 1 to 3 in the preparation of a cosmetic for soothing, repairing the skin barrier, reducing redness and / or stinging sensations.

9. The application according to claim 8, characterized in that, The cosmetics mentioned are serums, lotions, creams, or masks.

10. The application according to claim 9, characterized in that, The cosmetic product in question is a serum.

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