Fresh tissue fixing device

Abstract

The invention provides a fresh tissue fixing device. The upper half part of the fresh tissue fixing device comprises a pressurizing device, a moisture absorption buffer layer, a first pressurizing layer and a first pressurizing adjusting piece; and the lower half part of the fresh tissue fixing device comprises a group of fixing boxes and a pressurizing infusion device. According to the fixing device for the fresh tissue, a slice specimen of the fresh tissue can be conveniently fixed, stored and taken out, the slice of the fresh tissue can be kept flat through pressurization, the state of the slice of the fresh tissue can be well kept through permeation of fixing liquid, and subsequent detection and observation are facilitated. The fixing device for the fresh tissue has very important application value.

Description

Technical Field

[0001] This invention relates to medical devices, and more specifically, to a device for fixing fresh tissue. Background Technology

[0002] In the existing technology, the conventional procedure for obtaining organ / tissue specimens is to fix them first and then obtain the specimens. In particular, when obtaining large sections of prostate specimens after radical prostatectomy, there is currently no fixation device for fresh specimens (especially large sections).

[0003] Fresh tissue sections cannot typically be placed directly into fixative because fresh tissues, such as those from the prostate, have a certain surface tension. Direct placement can cause the sections to twist and deform, becoming misaligned and hindering paraffin block preparation. Furthermore, placing fresh tissue sections into the fixative requires a weighted object to maintain both fixation and flatness; currently, no such device exists. Therefore, there is an urgent need to develop novel fixation devices for fresh tissues. Summary of the Invention

[0004] To overcome the problems existing in the relevant prior art and facilitate the collection of fresh specimens, cutting them into sections, and then fixing the sections, the present invention provides a fixation device for fresh tissues. This device facilitates the fixation, storage, and removal of fresh tissue specimens. It can keep the sections of fresh tissues flat by applying pressure and allow the fixative to penetrate in order to maintain the condition of the sections of fresh tissues, which is beneficial for subsequent detection and observation.

[0005] This invention provides a device for fixing fresh tissue, the device being an openable and closable cuboid box, comprising:

[0006] The upper part of the fresh tissue fixation device includes: a pressure device, a moisture-absorbing buffer layer, a first pressure layer, and a first pressure adjusting component, wherein:

[0007] The pressurizing device has an internal lifting adjustment assembly, and the pressurizing device also has a first pressurizing adjustment component on its outer side. The lifting and lowering are adjusted via the first pressurizing adjustment component, allowing the first pressurizing layer to apply pressure to the slice of fresh tissue. The moisture-absorbing buffer layer is disposed between the pressurizing device and the first pressurizing layer.

[0008] The lower half of the fresh tissue fixation device includes: a set of fixation boxes and a pressurized infusion device, wherein the pressurized infusion device is a cuboid box without a top surface;

[0009] The fixing box includes at least four fixing compartments, each of which is rectangular and can hold a slice of fresh tissue. The outer wall of each fixing compartment is provided with a moisture-absorbing layer, and the outer wall of the fixing box is also provided with a slider. The slider cooperates with a slide rail provided on the upper part of the lower half of the inner wall of the fresh tissue fixing device, so that the fixing box can move relative to each other. The bottom of each fixing compartment is provided with several penetration holes near the side wall.

[0010] The pressurized infusion device is equipped with a movable box, which contains a liquid delivery layer, a pressurized buffer layer, a liquid storage layer, and a liquid absorption layer, each corresponding to a fixed compartment.

[0011] The movable box is equipped with a pressurization component, including a support component, an adjustment component, and a second pressurization adjustment component. The support component is located near the four corners of the lower half of the fresh tissue fixation device to support the movable box. The adjustment component is located at the midline of the long side of the bottom surface of the fresh tissue fixation device, and the movable box can be raised and lowered by adjusting the adjustment component to deliver liquid.

[0012] Preferably, the liquid delivery layer is a rigid, non-hygroscopic material, with a liquid guide groove provided on its top surface near the outer edge. The top surface of the liquid delivery layer also has seepage holes, and the bottom surface of the liquid delivery layer has at least two inlet ports. The liquid delivery layer contains an inlet chamber and inlet holes, allowing liquid to be delivered through the inlet ports, the inlet chamber, and the inlet holes within the liquid guide groove. The liquid delivery layer also contains seepage channels, allowing liquid to flow through the inlet ports and the seepage channels from the top surface of the liquid delivery layer.

[0013] The pressurized buffer layer is provided with a through pressurized buffer cavity, and the opening of the pressurized buffer cavity is correspondingly provided and communicates with the infusion port to facilitate liquid delivery;

[0014] The liquid storage layer is provided with a liquid storage chamber, and an infusion tube is provided on the liquid storage chamber. The infusion tube is also provided with an infusion tube port seal. When it is necessary to store fresh tissue slices, the infusion tube port seal is removed, and the infusion tube is inserted into the infusion chamber through the pressurized buffer chamber. This allows the liquid in the liquid storage chamber to flow through the infusion chamber to the fixed compartment when pressure is applied, so as to facilitate the infiltration and preservation of the fresh tissue slices.

[0015] The liquid-absorbing layer is a highly hygroscopic material that can absorb a large amount of liquid to prevent liquid from flowing out.

[0016] Preferably, the lifting adjustment component has the same structure as the adjustment component.

[0017] Preferably, the upper part of the fresh tissue fixation device is further provided with a first isolation layer and a first low temperature layer. The first isolation layer separates the upper part of the fresh tissue fixation device to provide a space for the first low temperature layer.

[0018] Preferably, the lower half of the fresh tissue fixation device is further provided with a second isolation layer and a second low temperature layer, the second isolation layer dividing the lower half of the fresh tissue fixation device to provide a space for the second low temperature layer.

[0019] Preferably, the fixing box includes 4-6 fixing compartments.

[0020] Preferably, the adjusting assembly includes a support column, a first screw, a second screw, a first adjusting helical gear, a second adjusting helical gear, a fixing block, a connecting shaft, a support rod, and a connecting assembly. The first adjusting helical gear and the second adjusting helical gear are connected to the first screw and the second screw via the connecting shaft, and are connected to the support column via the support rod and the fixing block. The connecting shaft passes through the side wall of the movable box and the pressurized infusion device and is connected to the connecting assembly and the second pressurized adjusting component.

[0021] Preferably, the fresh tissue fixation device may also be provided with a cover, which is more conducive to preventing liquid leakage.

[0022] Preferably, three inlet ports are provided on the bottom surface of the liquid delivery layer.

[0023] Preferably, the infusion tube is correspondingly arranged with the pressurization buffer chamber to avoid pressing the infusion tube when pressurized, so as to facilitate infusion (or liquid delivery), thereby allowing the liquid in the storage chamber to flow through the infusion chamber to the fixed compartment when pressure is applied, which is conducive to the infiltration and preservation of the slices of fresh tissue.

[0024] The beneficial effects of the present invention include at least the following:

[0025] The fresh tissue fixation device of the present invention facilitates the fixation, storage, and retrieval of fresh tissue slides. It can maintain the flatness of fresh tissue slides through pressure and allow fixative to penetrate, thus effectively preserving the state of the fresh tissue slides, which is beneficial for subsequent testing and observation. The fresh tissue fixation device of the present invention has very important application value.

[0026] The features and advantages of the present invention will be described in detail in the following detailed description section. Attached Figure Description

[0027] Figure 1 This is a schematic diagram of a structure of the fresh tissue fixation device in this invention.

[0028] Figure 2 This is a schematic diagram of the structure of a liquid delivery layer, a pressure buffer layer, a liquid storage layer, and a liquid absorption layer corresponding to the fixation grid in the fresh tissue fixation device of the present invention.

[0029] Figure 3 This is a schematic diagram of the structure of a liquid delivery layer in the fresh tissue fixation device of the present invention.

[0030] Figure 4 This is a schematic diagram of another liquid delivery layer in the fresh tissue fixation device of the present invention.

[0031] Figure 5 for Figure 4 A partially enlarged view of another liquid delivery layer of the fresh tissue fixation device of the present invention.

[0032] Figure 6 This is a schematic diagram of the adjustment assembly of the fresh tissue fixation device of the present invention.

[0033] Explanation of reference numerals in the attached drawings: 1. Pressurizing device; 1-1. Cover; 2. Moisture-absorbing buffer layer; 3. First pressurizing layer; 4. First pressurizing adjustment component; 5. Isolation layer; 6. Low-temperature component; 7. Fixing box; 8. Moisture-absorbing layer; 9. Fixing grid; 10. Slider; 11. Slide rail; 12. Pressurized infusion device; 13. Moving box; 14. Support component; 15. Adjustment component; 16. Second pressurizing adjustment component; 17. Infiltration hole; 18. Liquid delivery layer; 19. Liquid guide channel; 2 0. Infusion chamber; 21. Infusion hole; 22. Leakage hole; 23. Leakage channel; 24. Infusion port; 25. Pressurized buffer layer; 26. Pressurized buffer chamber; 27. Liquid storage layer; 28. Liquid storage chamber; 29. ​​Infusion tube; 30. Infusion tube port seal; 31. Absorbent layer; 32. First screw; 32'. Second screw; 33. First adjusting helical gear; 33'. Second adjusting helical gear; 34. Fixing block; 35. Connecting shaft; 36. Support rod; 37. Connecting assembly. Detailed Implementation

[0034] The specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings. It should be understood that the specific embodiments described herein are for illustration and explanation only and are not intended to limit the present invention.

[0035] In this invention, unless otherwise stated, directional terms such as "up," "down," "ascend," "descend," "left," "right," "inner," "outer," "far," and "near" generally refer to the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this application and simplifying the description, and are not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application.

[0036] In the description of this application, unless otherwise stated, "multiple" means two or more. Furthermore, the terms "comprising," "including," and any variations thereof are intended to cover non-exclusive inclusion.

[0037] In this invention, it should also be noted that, unless otherwise explicitly specified and limited, the terms "set up," "equipped with," "connected," and "interconnected" should be interpreted broadly, referring to fixed connections or detachable connections, such as connections using screws, bolts, or clips; direct connections or indirect connections via an intermediate medium; and internal connections between two components. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0038] like Figure 1 As shown, the present invention provides a fresh tissue fixation device, the fresh tissue fixation device being an openable and closable cuboid box, comprising:

[0039] The upper part of the fresh tissue fixation device includes: a pressure device 1, a moisture-absorbing buffer layer 2, a first pressure layer 3, and a first pressure adjusting component 4, wherein:

[0040] The pressurizing device 1 has an internal lifting adjustment assembly, and the pressurizing device 1 also has a first pressurizing adjustment member 4 on its outer side. The lifting and lowering are adjusted via the first pressurizing adjustment member 4, allowing the first pressurizing layer 3 to apply pressure to the fresh tissue slice. The moisture-absorbing buffer layer 2 is disposed between the pressurizing device 1 and the first pressurizing layer 3. The moisture-absorbing buffer layer 2 is made of a rigid absorbent material, which not only absorbs excess liquid but also buffers the pressure applied to the fresh tissue slice by the pressurizing device 1 and the first pressurizing layer 3.

[0041] The lower half of the fresh tissue fixation device includes: a set of fixation boxes 7 and a pressurized infusion device 12, wherein the pressurized infusion device 12 is a cuboid box without a top surface;

[0042] The fixing box 7 includes at least four fixing compartments 9, each of which is rectangular and can accommodate a slice of fresh tissue. The outer wall of each fixing compartment 9 is provided with a moisture-absorbing layer 8, and the outer wall of the fixing box 7 is also provided with sliders 10. The sliders 10 cooperate with the slide rails 11 provided on the upper part of the lower half of the inner wall of the fresh tissue fixing device, so that the fixing box 7 can move relative to each other. The bottom of the fixing compartment 9 near the side wall is provided with several penetration holes 17, which can both ensure the fresh tissue slice is flat and allow the fixative to penetrate.

[0043] The pressurized infusion device 12 is provided with a movable box 13, which is provided with a liquid delivery layer 18, a pressurized buffer layer 25, a liquid storage layer 27 and a liquid absorption layer 31 corresponding to each fixed compartment.

[0044] The movable box 13 is provided with a pressure assembly, including a support assembly 14, an adjustment assembly 15, and a second pressure adjustment component 16. The support assembly is located near the four corners of the lower half of the fresh tissue fixation device to support the movable box 13. The adjustment assembly 15 is located at the center line of the long side of the bottom surface of the fresh tissue fixation device, and the movable box 13 can be raised and lowered by adjusting the adjustment assembly 15.

[0045] In this invention, the fixative can be a commonly used solution for preserving fresh tissues, such as formalin solution.

[0046] In some preferred embodiments, such as Figure 2 As shown, the liquid delivery layer 18 is made of a rigid, non-hygroscopic material. A liquid guide groove 19 is provided on the outer edge of its top surface. The top surface of the liquid delivery layer 18 also has seepage holes 22. At least two inlet ports 24 are provided on the bottom surface of the liquid delivery layer. An inlet chamber 20 and inlet holes 21 are provided inside the liquid delivery layer 18, allowing liquid to be delivered through the inlet ports 24, the inlet chamber 20, and the inlet holes 21 within the liquid guide groove 19. A seepage channel 23 is provided inside the liquid delivery layer 18, allowing liquid to flow through the inlet ports 24 and the seepage channel 23 from the top surface of the liquid delivery layer 18.

[0047] The pressurized buffer layer 25 is provided with a through pressurized buffer cavity 26, the opening of the pressurized buffer cavity 26 is correspondingly provided with and communicates with the infusion port 24 to facilitate liquid delivery;

[0048] The liquid storage layer 27 is provided with a liquid storage chamber 28, and an infusion tube 29 is provided on the liquid storage chamber 28. The infusion tube is also provided with an infusion tube port seal 30. When it is necessary to store fresh tissue slices, the infusion tube port seal 30 is removed, and the infusion tube 29 is inserted into the infusion chamber 20 through the pressurized buffer chamber 26, so that when pressure is applied, the liquid in the liquid storage chamber can flow through the infusion chamber 20 to the fixed compartment, which is conducive to the infiltration and preservation of the fresh tissue slices.

[0049] The liquid-absorbing layer 31 is a highly hygroscopic material (such as superabsorbent polymer (SAP)) that can absorb a large amount of liquid to prevent liquid from flowing out.

[0050] In this invention, the diameter of the cavity in the infusion chamber 20 is typically 1-3 mm, and the cavity structure can be a regular cylindrical cavity (e.g., Figure 1 and Figure 2As shown), it can also be a preferred irregular curved cavity (such as...). Figure 3 As shown), it can also be a more preferred irregular helical cavity (such as...). Figure 4 and Figure 5 (As shown), to facilitate the transport of liquid during pressurization, and also to help maintain moisture.

[0051] In some preferred embodiments, such as Figure 6 As shown, the lifting adjustment assembly has the same structure as the adjustment assembly 15. In some more preferred embodiments, the adjustment assembly 15 includes a support column, a first screw 32, a second screw 32', a first adjusting helical gear 33, a second adjusting helical gear 33', a fixing block 34, a connecting shaft 35, a support rod 36, and a connecting assembly 37. The first adjusting helical gear 33 and the second adjusting helical gear 33' are connected to each other via the connecting shaft 35 and cooperate with the first screw 32 and the second screw 32'. They are also connected to the support column via the support rod 36 and the fixing block 34. The connecting shaft 35 passes through the side wall of the movable box 13 and the pressurized infusion device 12 and is connected to the connecting assembly 37 and the second pressurized adjustment member 16.

[0052] In some preferred embodiments, the fixing box includes 4-6 fixing compartments. In some more preferred embodiments, the fixing box includes 5 fixing compartments, such as... Figure 1 As shown.

[0053] In some preferred embodiments, the moisture-absorbing buffer layer 2 uses a rigid liquid-absorbing material, which is a rigid sponge.

[0054] In some preferred embodiments, each fixed cell has 10-30 infiltration holes with a diameter of 2-4 mm at least 1-3 cm from the bottom of the sidewalls near the two long sides, to allow liquid to penetrate more easily, such as... Figure 1 and Figure 2 As shown.

[0055] In some preferred embodiments, such as Figure 1 As shown, the upper part of the fresh tissue fixation device is further provided with a first isolation layer 5 and a first low temperature layer 6. The first isolation layer 5 divides the upper part of the fresh tissue fixation device to provide a space for the first low temperature layer 6.

[0056] In some preferred embodiments, the first cryogenic layer 6 contains ice packs, and the top of the first cryogenic layer 6 can be opened to replace the ice packs.

[0057] In some preferred embodiments, the lower half of the fresh tissue fixation device is further provided with a second isolation layer and a second low-temperature layer. The second isolation layer separates the lower half of the fresh tissue fixation device to provide a space for the second low-temperature layer (not shown in the figure, but still within the scope of protection of this invention).

[0058] In some preferred embodiments, the fresh tissue fixation device may also be provided with a cover 1-1, which further facilitates sealing and prevents liquid leakage, such as... Figure 1 As shown.

[0059] In some preferred embodiments, three inlet ports 24 are provided on the bottom surface of the liquid delivery layer 18, such as... Figures 2 to 4 As shown.

[0060] In some preferred embodiments, the infusion tube 29 is correspondingly arranged with the pressurization buffer chamber 26 to prevent the infusion tube 29 from being blocked during pressurization, thereby facilitating infusion. This allows the liquid in the storage chamber to flow through the infusion chamber 20 to the fixed compartment when pressure is applied, thus facilitating the infiltration and preservation of the fresh tissue slices. Figure 2 As shown.

[0061] The fresh tissue fixation device of the present invention facilitates the fixation, storage, and retrieval of fresh tissue slides. It can maintain the flatness of fresh tissue slides through pressure and allow fixative to penetrate, thus effectively preserving the state of the fresh tissue slides, which is beneficial for subsequent testing and observation. The fresh tissue fixation device of the present invention has very important application value.

[0062] The embodiments of the present invention have been described in detail above with reference to the accompanying drawings, but the present invention is not limited thereto. Those skilled in the art can make various modifications, equivalent substitutions, or improvements within the spirit and principle of the present invention. To avoid unnecessary repetition, the present invention will not describe various possible combinations separately, but these variations and combinations should also be considered as the content disclosed in the present invention and all fall within the protection scope of the present invention.

Claims

1. A device for the fixation of fresh tissue, characterized in that The fresh tissue fixing device is a whole openable cuboid box, comprising: The upper half of the fresh tissue fixing device comprises a pressurizing device, a moisture absorbing buffer layer, a first pressurizing layer and a first pressurizing adjusting member, wherein: The pressurizing device is internally provided with a lifting adjusting assembly, and the outer side of the pressurizing device is provided with the first pressurizing adjusting member, so that the first pressurizing layer can exert pressure on the fresh tissue slice by adjusting the lifting through the first pressurizing adjusting member, and the moisture absorbing buffer layer is arranged between the pressurizing device and the first pressurizing layer; and The lower half of the fresh tissue fixing device comprises a group of fixing boxes and a pressurizing infusion device, and the pressurizing infusion device is a cuboid box without top surface, wherein: The group of fixing boxes comprises at least four fixing grids, each of which is a cuboid and can accommodate a fresh tissue slice; the outer wall of the fixing grid is provided with a moisture absorbing layer, and the outer wall of the fixing box is also oppositely provided with a sliding block, which cooperates with a slide arranged above the inner wall of the lower half of the fresh tissue fixing device, so that the fixing box can move relatively; a plurality of infiltration holes are arranged at the bottom of the fixing grid near the side wall; The pressurizing infusion device is internally provided with a moving box, and the moving box is internally provided with a liquid delivery layer, a pressurizing buffer layer, a liquid storage layer and a liquid absorbing layer corresponding to each fixing grid; The moving box is provided below with a pressurizing assembly comprising a supporting assembly, an adjusting assembly and a second pressurizing adjusting member, the supporting assembly is arranged near the four corners of the lower half of the fresh tissue fixing device to support the moving box, and the adjusting assembly is arranged at the position of the middle line of the long side of the bottom surface of the fresh tissue fixing device, and the moving box can be adjusted in lifting by adjusting the adjusting assembly to deliver liquid.

2. The fresh tissue fixing device according to claim 1, wherein: The liquid delivery layer is a hard non-hygroscopic material, the top surface of which is provided with a liquid guiding groove near the edge of the outer side, the top surface of the liquid delivery layer is also provided with an infiltration hole, at least two liquid delivery ports are arranged at the bottom surface of the liquid delivery layer, and a liquid delivery cavity and a liquid delivery hole are arranged in the interior of the liquid delivery layer, so that liquid can be delivered from the liquid delivery hole in the liquid guiding groove through the liquid delivery cavity and the liquid delivery port; the interior of the liquid delivery layer is provided with an infiltration channel, so that liquid can flow from the top surface of the liquid delivery layer through the infiltration channel and the liquid delivery port; The pressurizing buffer layer is provided with a pressurizing buffer cavity penetrating therethrough, and the opening of the pressurizing buffer cavity is correspondingly arranged and communicated with the liquid delivery port, so as to facilitate liquid delivery; The liquid storage layer is internally provided with a liquid storage cavity, and the liquid storage cavity is provided with a liquid delivery tube, and the liquid delivery tube is also provided with a liquid delivery tube port sealing member, when it is necessary to store a fresh tissue slice, the liquid delivery tube port sealing member is removed, and the liquid delivery tube is inserted into the liquid delivery cavity through the pressurizing buffer cavity, so that when pressure is applied, the liquid in the liquid storage cavity can flow into the fixing grid through the liquid delivery cavity, so as to facilitate infiltration and preservation of the fresh tissue slice; The liquid absorbing layer is a strong hygroscopic material, which can absorb a large amount of liquid to prevent liquid from flowing out.

3. A device for the fixation of fresh tissue according to claim 1 or 2, characterized in that The lifting adjusting assembly is the same in structure as the adjusting assembly.

4. A device for the fixation of fresh tissue according to claim 1 or 2, characterized in that The upper half of the fresh tissue fixing device is further provided with a first isolation layer and a first low-temperature layer.

5. A device for the fixation of fresh tissue according to claim 1 or 2, characterized in that The lower half of the fresh tissue fixing device is further provided with a second isolation layer and a second low-temperature layer.

6. A device for the fixation of fresh tissue according to claim 1 or 2, characterized in that The fixing box comprises 4-6 fixing grids.

7. The device for fixation of fresh tissue according to claim 3, characterized in that The adjusting assembly comprises a supporting column, a first screw rod, a second screw rod, a first adjusting helical gear, a second adjusting helical gear, a fixing block, a connecting shaft, a supporting rod and a connecting assembly, wherein the first adjusting helical gear and the second adjusting helical gear are connected by the connecting shaft and matched with the first screw rod and the second screw rod, and connected with the supporting column by the supporting rod and the fixing block, the connecting shaft penetrates the side wall of the moving box and the pressurized infusion device and is connected with the connecting assembly and the second pressurized adjusting member.

8. The device for fixation of fresh tissue according to claim 1, characterized in that The fresh tissue fixing device can be further provided with a cover, which is more conducive to preventing liquid from flowing out.

9. The device for fixation of fresh tissue according to claim 2, characterized in that The bottom surface of the liquid delivery layer is provided with three infusion ports.

10. The device for fixation of fresh tissue according to claim 2, characterized in that The infusion pipe is correspondingly arranged with the pressurized buffer cavity, so as to avoid pressing the infusion pipe when pressurizing, facilitate infusion, and enable the liquid in the liquid storage cavity to flow into the fixing grid through the infusion cavity when pressure is applied, thereby facilitating infiltration and preservation of the fresh tissue slices.

Images