Chaixiang depression-relieving pill as well as preparation method and application thereof

Abstract

The invention provides a firewood-fragrance depression-relieving pill as well as a preparation method and application thereof, and relates to the technical field of traditional Chinese medicines. The radix bupleuri and rhizoma cyperi depression-relieving pill is prepared from the following raw materials in parts by weight: 5 to 10 parts of radix bupleuri, 5 to 10 parts of rhizoma cyperi, 5 to 15 parts of radix paeoniae alba, 3 to 10 parts of fructus aurantii immaturus, 5 to 10 parts of radix rehmanniae, 5 to 10 parts of poria cocos, 5 to 10 parts of flos albiziae, 5 to 10 parts of fructus hordei germinatus, 5 to 10 parts of fructus ziziphi jujubae and 2 to 10 parts of liquorice root. The traditional Chinese medicine composition is compatible aiming at liver depression and spleen deficiency type depression syndromes. The liver soothing and qi regulating (radix bupleuri, rhizoma cyperi, fructus aurantii immaturus and raw malt) is used as a core, blood nourishing and liver nourishing (radix paeoniae alba and radix rehmanniae), spleen strengthening and stomach harmonizing (poria cocos, Chinese dates, liquorice and raw malt) and heart calming and nerve soothing (albizia flowers, poria cocos and Chinese dates) are used as auxiliary materials, the pathological states of qi stagnation, blood deficiency, spleen weakness, spirit disturbance and the like caused by liver depression are comprehensively conditioned, and the effects of soothing liver-qi stagnation, tonifying spleen, regulating qi, nourishing blood and tranquilizing are achieved; the traditional Chinese medicine is suitable for depression caused by liver depression, spleen deficiency and malnutrition.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and in particular to a Chaixiang Jieyu Pill, its preparation method, and its application. Background Technology

[0002] Depression, also known as depressive disorder (DD), is one of the most prevalent mental illnesses in the world. Its main clinical manifestations include depressed mood, mood disorders, loss of interest, anxiety, and insomnia. In severe cases, suicidal tendencies may occur [1]. The suicide risk of patients with depression is 30 times that of normal people. About 1 million people commit suicide due to depression every year worldwide. The authoritative medical journal The Lancet has listed depression as the third largest disease burden in the world, and it is expected to become the first by 2030. Therefore, it is of great significance to develop effective drugs for the prevention and treatment of depression.

[0003] Currently, medications such as paroxetine and sertraline are available for treating anxiety disorders, but long-term use can leave residues and cause adverse reactions such as intestinal discomfort. Although some milder traditional Chinese medicines have also emerged, their therapeutic effects have not met expectations. Summary of the Invention

[0004] In view of this, the present invention proposes a Chaixiang Jieyu Pill, its preparation method and application.

[0005] The technical solution of this invention is implemented as follows: A Chaixiang Jieyu Pill comprises the following ingredients in parts by weight: Bupleurum chinense 5-10 parts, Cyperus rotundus 5-10 parts, Paeonia lactiflora 5-15 parts, Citrus aurantium 3-10 parts, Rehmannia glutinosa 5-10 parts, Poria cocos 5-10 parts, Albizia julibrissin flower 5-10 parts, Hordeum vulgare 5-10 parts, Ziziphus jujuba 5-10 parts, and Glycyrrhiza uralensis 2-10 parts.

[0006] Furthermore, the Chaixiang Jieyu Pill comprises the following ingredients in parts by weight: Bupleurum chinense 5-8 parts, Cyperus rotundus 5-8 parts, Paeonia lactiflora 5-8 parts, Citrus aurantium 5-8 parts, Rehmannia glutinosa 5-8 parts, Poria cocos 5-8 parts, Albizia julibrissin flower 5-8 parts, Hordeum vulgare 5-8 parts, Ziziphus jujuba 5-8 parts, Glycyrrhiza uralensis 5-8 parts.

[0007] Furthermore, the Chaixiang Jieyu Pill comprises the following ingredients in parts by weight: Bupleurum chinense 6 parts, Cyperus rotundus 6 parts, Paeonia lactiflora 6 parts, Citrus aurantium 6 parts, Rehmannia glutinosa 6 parts, Poria cocos 6 parts, Albizia julibrissin 6 parts, Hordeum vulgare 6 parts, Ziziphus jujuba 6 parts, and Glycyrrhiza uralensis 6 parts.

[0008] Furthermore, the Cyperus rotundus is vinegar-processed Cyperus rotundus; the Citrus aurantium is bran-fried Citrus aurantium; the Rehmannia glutinosa is raw Rehmannia glutinosa; the malt is raw malt; and the jujube is pitted jujube.

[0009] The preparation method of Chaixiang Jieyu Pills includes the following steps: crushing ten herbs, namely Bupleurum, Cyperus, White Peony Root, Fructus Aurantii Immaturus, Rehmanniae Radix, Poria, Albiziae Fructus, Malt, Jujubae Fructus, and Glycyrrhizae Radix, into fine powder, sieving, mixing, making into water pills, and drying, to obtain the product.

[0010] Furthermore, the sieve mesh size is 80-100 mesh.

[0011] The application of Chaixiang Jieyu Pills in the preparation of medicines for liver qi stagnation, liver qi stagnation and spleen deficiency, liver qi stagnation transforming into fire, deficiency of both heart and spleen, disharmony between heart and kidney, and kidney deficiency and liver qi stagnation.

[0012] Furthermore, the application of the Chaixiang Jieyu Pill in the preparation of medicines for depression caused by liver stagnation, spleen deficiency, and malnourishment of the mind.

[0013] Furthermore, the application of the Chaixiang Jieyu Pill in the preparation of medicines for liver stagnation and spleen deficiency, as well as accompanying symptoms such as restlessness, poor appetite due to spleen deficiency, and blood deficiency.

[0014] The medicinal materials used in this invention are sourced as follows: 1. Bupleurum This product is the dried root of Bupleurum chinense DC. or Bupleurum corzonerifolium Willd., both belonging to the Apiaceae family. Based on their different characteristics, they are commonly known as "Northern Bupleurum" and "Southern Bupleurum," respectively. It is harvested in spring and autumn, and the stems, leaves, and soil are removed before drying.

[0015] This product uses the dried root of Bupleurum chinense DC., a plant belonging to the Apiaceae family. It is commonly known as "Northern Bupleurum". This product complies with the relevant provisions of Bupleurum chinense in Part I of the 2025 edition of the Chinese Pharmacopoeia.

[0016] 2. Cyperus rotundus This product is the dried rhizome of Cyperus rotundus L., a plant belonging to the Cyperaceae family. It is harvested in autumn, the hairs are singed off, and then it is briefly boiled or steamed in boiling water before being sun-dried, or singed and then sun-dried directly.

[0017] Take Cyperus rotundus slices (grains) and stir-fry them until dry according to the vinegar-processing method (General Rule 0213).

[0018] This product complies with the relevant provisions of Cyperus rotundus in Part I of the 2025 edition of the Chinese Pharmacopoeia.

[0019] 3. White peony root This product is the dried root of Paeonia lactiflora Pall., a plant belonging to the Ranunculaceae family. It is harvested in summer and autumn, washed, and the head, tail, and fine roots are removed. It is then boiled in boiling water to remove the outer skin, or the skin is removed before boiling, and finally dried in the sun.

[0020] This product complies with the relevant provisions of the Chinese Pharmacopoeia 2025 edition, Part I, under the entry for white peony root.

[0021] 4. Fructus Aurantii Immaturus This product is the dried young fruit of Citrus aurantium L. (a plant in the Rutaceae family) and its cultivated varieties, or Citrus sinensis Osbeck (a sweet orange). The fallen fruit is collected in May and June, impurities are removed, and the fruit is cut in half horizontally from the middle. It is then sun-dried or dried at low temperature. Smaller fruits are directly sun-dried or dried at low temperature.

[0022] The bitter orange used in this product is the dried young fruit of Citrus aurantium L., a plant of the Rutaceae family.

[0023] To stir-fry immature bitter orange with wheat bran, take slices of immature bitter orange and stir-fry them according to the method of stir-frying with wheat bran (General Rule 0213) until the color turns dark.

[0024] This product complies with the relevant provisions of the Chinese Pharmacopoeia 2025 edition, Part I, under the entry for Citrus aurantium.

[0025] 5. Rehmannia This product is the fresh or dried tuberous root of Rehmannia glutinosa Libosch., a plant belonging to the Scrophulariaceae family. It is harvested in autumn, and the rhizome, fibrous roots, and soil are removed before use; or the Rehmannia root can be slowly baked until it is about 80% dry. The former is commonly known as "fresh Rehmannia root", and the latter is commonly known as "raw Rehmannia root".

[0026] The Rehmannia glutinosa used in this product is raw Rehmannia glutinosa.

[0027] This product complies with the relevant provisions of the Chinese Pharmacopoeia 2025 edition, Part I, under the entry for Citrus aurantium.

[0028] 6. Poria cocos This product is the dried sclerotium of the fungus *Poria cocos* (Schw.) Wolf, belonging to the Polyporaceae family. It is mostly harvested from July to September. After being dug up, the mud and sand are removed, and the fungus is piled up to "sweat," then spread out to dry until the surface is dry. This process of "sweating" is repeated several times until wrinkles appear and most of the internal moisture is lost. Finally, it is air-dried and called "Poria cocos pieces." Alternatively, fresh Poria cocos can be cut into different parts and air-dried, resulting in "Poria cocos chunks" and "Poria cocos slices," respectively.

[0029] This product complies with the relevant provisions of the Poria cocos section of Part I of the 2025 edition of the Chinese Pharmacopoeia.

[0030] 7. Albizia julibrissin flower This product is the dried inflorescence or flower bud of Albizia julibrissin Durazz., a plant belonging to the legume family. It is harvested on sunny days during the summer when the flowers are in bloom or when the flower buds are forming, and then dried promptly. The former is commonly known as "Albizia flower," and the latter as "Albizia rice."

[0031] This product complies with the relevant provisions of the Albizia julibrissin flower section of Part I of the 2025 edition of the Chinese Pharmacopoeia.

[0032] 8. Malt This product is a processed product made from the mature fruit of barley (Hordeum vulgare L.), a plant of the Poaceae family, after germination and drying. The barley grains are soaked in water, kept at a suitable temperature and humidity, and dried in the sun or at low temperature when the sprouts reach approximately 5mm in length.

[0033] This product uses raw malt. This product complies with the relevant provisions of the Malt section of Part I of the 2025 edition of the Chinese Pharmacopoeia.

[0034] 9. Jujube This product is the dried, ripe fruit of the jujube plant (Ziziphus jujuba Mill.), belonging to the Rhamnaceae family. The fruit is harvested in autumn when ripe and then sun-dried.

[0035] This product uses pitted jujubes.

[0036] This product complies with the relevant provisions of the Jujube section of Part I of the 2025 edition of the Chinese Pharmacopoeia.

[0037] 10. Licorice This product is the dried root and rhizome of Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat., or Glycyrrhiza glabra L., both belonging to the Fabaceae family. It is harvested in spring and autumn, the fibrous roots are removed, and it is then sun-dried.

[0038] The licorice used in this product is the dried root and rhizome of Glycyrrhiza uralensis Fisch., a plant belonging to the Fabaceae family.

[0039] This product complies with the relevant provisions of the Jujube section of Part I of the 2025 edition of the Chinese Pharmacopoeia.

[0040] In the prescription of this invention, Bupleurum is pungent, bitter, and slightly cold in nature. It enters the liver, gallbladder, and lung meridians; it disperses and reduces fever, soothes the liver and relieves depression, and raises yang qi; Bupleurum is the principal herb in the prescription for soothing the liver and relieving depression.

[0041] Cyperus rotundus is pungent, slightly bitter, and slightly sweet, and neutral in nature; it enters the liver, spleen, and triple burner meridians; it soothes the liver and relieves stagnation, regulates qi and relieves chest tightness, regulates menstruation and relieves pain. Paeonia lactiflora is bitter, sour, and slightly cold in nature. It enters the liver and spleen meridians. Its functions include nourishing blood and regulating menstruation, astringing yin and stopping sweating, softening the liver and relieving pain, and calming liver yang. Stir-frying with wheat bran moderates its qi-dispersing properties. Citrus aurantium promotes qi circulation and relieves bloating, guiding stagnation downwards. When combined with Bupleurum chinense, the ascending and descending actions harmonize the qi mechanism of the middle burner, relieving abdominal distension, fullness, discomfort, and belching caused by liver stagnation affecting the spleen. Its qi-dispersing power helps to clear stagnation. Vinegar-processed Cyperus rotundus, Paeonia lactiflora, and wheat bran-stir-fried Citrus aurantium serve as assistant herbs to soothe the liver, regulate qi, nourish blood, soften the liver, and promote qi circulation and relieve bloating.

[0042] Rehmannia glutinosa is sweet and cold in nature. It enters the heart, liver, and kidney meridians. It clears heat and cools the blood, nourishes yin and generates fluids. Poria cocos is sweet and bland in nature, and neutral in nature. It enters the heart, lung, spleen, and kidney meridians. It promotes diuresis and eliminates dampness, strengthens the spleen, and calms the mind. Albizia julibrissin is sweet and neutral in nature. It enters the heart and liver meridians. It relieves depression and calms the mind. Barley malt is sweet and neutral in nature. It enters the spleen and stomach meridians. It regulates qi and promotes digestion, strengthens the spleen and improves appetite. Barley malt soothes the liver and relieves depression, alleviating loss of appetite and abdominal distension caused by liver qi stagnation, promoting digestion and strengthening the stomach, and improving spleen and stomach function. Its liver-soothing effect is mild and not harsh. Jujube (pitted) is sweet and warm in nature. It enters the spleen, stomach, and heart meridians. It tonifies the middle jiao and replenishes qi, nourishes blood and calms the mind. Rehmannia glutinosa, Poria cocos, Albizia julibrissin, barley malt, and jujube are used as adjuvant herbs to clear heat and nourish yin, strengthen the spleen and calm the mind, relieve depression and calm the mind, regulate qi and harmonize the stomach, and tonify the spleen and nourish blood.

[0043] In this formula, jujube tonifies the spleen, assists Poria in strengthening the spleen, supports vital energy, and nourishes blood; together with white peony root and rehmannia root, it nourishes blood and softens the liver; it helps Poria and Albizia flower calm the mind and soothe the nerves; it moderates the properties of the medicine, harmonizes the effects of the other medicines, reduces the irritation and dryness of Bupleurum and immature bitter orange, and protects the spleen and stomach.

[0044] Licorice is sweet and neutral in nature. It enters the heart, lung, spleen, and stomach meridians. It tonifies the spleen and replenishes qi, clears heat and detoxifies, relieves spasms and pain, and harmonizes the effects of other herbs.

[0045] Compared with the prior art, the beneficial effects of the present invention are: This formula is designed for depression caused by liver stagnation and spleen deficiency. Its core ingredients are Bupleurum, Cyperus, Fructus Aurantii Immaturus, and Malt. It is supplemented with herbs that nourish blood and soften the liver (Radix Paeoniae Alba, Radix Rehmanniae), strengthen the spleen and stomach (Poria, Fructus Jujuba, Radix Glycyrrhizae, and Malt), and calm the mind and soothe the nerves (Flos Albiziae, Poria, and Fructus Jujuba). This comprehensive approach addresses the pathological states caused by liver stagnation, including qi stagnation, blood deficiency, spleen weakness, and mental disturbance, achieving the effects of soothing the liver and relieving depression, strengthening the spleen and regulating qi, nourishing blood and calming the mind. It is suitable for depression caused by liver stagnation and spleen deficiency, and malnourishment of the heart and spirit. Symptoms include low mood, suspicion and anxiety, frequent sighing, insomnia, chest and rib distension, fatigue, epigastric fullness and belching, loose or dry stools, pale tongue, thin tongue coating, and a wiry, thready, or slippery pulse. Detailed Implementation

[0046] To better understand the technical content of this invention, specific embodiments are provided below to further illustrate the invention.

[0047] Unless otherwise specified, the experimental methods used in the embodiments of this invention are all conventional methods.

[0048] Unless otherwise specified, all materials and reagents used in the embodiments of this invention are commercially available.

[0049] Example 1 Chaixiang Jieyu Pills: Take 6g of Bupleurum, 6g of Cyperus rotundus (processed with vinegar), 6g of Paeonia lactiflora, 6g of Citrus aurantium (stir-fried with wheat bran), 6g of Rehmannia glutinosa, 6g of Poria cocos, 6g of Albizia julibrissin, 6g of Hordeum vulgare, 6g of Ziziphus jujuba (pitted), and 6g of Glycyrrhiza uralensis. Grind the ten herbs into a fine powder, pass through an 80-mesh sieve, mix well, make into water pills, and dry.

[0050] Example 2 Chaixiang Jieyu Pills: Take 8g of Bupleurum, 8g of Cyperus rotundus (processed with vinegar), 8g of Paeonia lactiflora, 5g of Citrus aurantium (stir-fried with wheat bran), 5g of Rehmannia glutinosa (raw), 5g of Poria cocos, 5g of Albizia julibrissin (flower), 5g of Hordeum vulgare (raw), 5g of Ziziphus jujuba (pitted), and 6g of Glycyrrhiza uralensis. Grind the ten herbs into a fine powder, pass through an 80-mesh sieve, mix well, make into water pills, and dry.

[0051] Example 3 Chaixiang Jieyu Pills: Take 7g of Bupleurum chinense, 7g of Cyperus rotundus (processed with vinegar), 6g of Paeonia lactiflora, 6g of Citrus aurantium (stir-fried with wheat bran), 6g of Rehmannia glutinosa, 6g of Poria cocos, 5g of Albizia julibrissin, 5g of Hordeum vulgare, 5g of Ziziphus jujuba (pitted), and 7g of Glycyrrhiza uralensis. Grind the ten herbs into a fine powder, pass through an 80-mesh sieve, mix well, make into water pills, and dry.

[0052] Test case 1. Materials and Methods 1.1 General Information Referring to the relevant content of *Guiding Principles for Clinical Research of New Traditional Chinese Medicines (Trial Implementation)*, China Medical Science and Technology Press, 2002; *General Principles for Clinical Research of New Traditional Chinese Medicines* (Center for Drug Evaluation, National Medical Products Administration, November 2015); and *Guidelines for Clinical Diagnosis and Treatment of Internal Medicine in Traditional Chinese Medicine* (compiled by the China Association of Traditional Chinese Medicine, 1st edition, January 2020), 60 cases meeting the inclusion criteria were randomly selected from outpatients between June 2020 and June 2025. Of the 60 patients, 23 were male and 37 were female, with a mean age of (42.95±10.32) years.

[0053] 1.2 Diagnostic criteria Diagnostic criteria for Depression in Traditional Chinese Medicine (TCM): Diagnosis is based on the *Guidelines for Clinical Diagnosis and Treatment of Internal Medicine in Traditional Chinese Medicine* (compiled by the China Association of Traditional Chinese Medicine, 1st edition, January 2020). Depression in TCM is characterized by symptoms such as depressed mood, emotional instability, chest tightness, hypochondriac pain, irritability, tearfulness, or a feeling of something stuck in the throat. The syndrome is diagnosed as Liver Qi Stagnation and Spleen Deficiency.

[0054] Symptoms include low mood, suspicion and worry, frequent sighing, insomnia, chest and rib distension, fatigue, epigastric fullness and belching, loose or dry stools, pale tongue, thin tongue coating, and wiry or slippery pulse.

[0055] 1.3 Inclusion Criteria (1) Patients with depression who meet the diagnostic criteria of TCM syndrome are diagnosed as liver stagnation and spleen deficiency syndrome.

[0056] (2) Adults aged 18-60.

[0057] (3) The patient gave informed consent and voluntarily accepted the treatment.

[0058] (4) Treatment and follow-up have been completed as required.

[0059] 1.4 Exclusion Criteria (1) Patients with depression whose primary diagnosis is asthma, palpitations, chest pain, insomnia, stomach pain, epigastric fullness, headache, dizziness, goiter, hypochondriac pain, impotence, sweating, internal injury fever, cancer, etc.

[0060] (2) Patients with mania, dementia, epilepsy, or stroke.

[0061] (3) Emotional problems caused by other specific diseases vary with the severity of the primary disease.

[0062] (4) Pregnant or lactating women.

[0063] (5) Those who have participated in or are currently participating in other clinical trials within the past month.

[0064] (6) Individuals allergic to this preparation.

[0065] 1.5 Treatment Methods Sixty eligible patients were randomly selected to receive single-drug treatment (referring to the "Clinical Diagnosis and Treatment Guidelines for Internal Medicine in Traditional Chinese Medicine" (compiled by the China Association of Traditional Chinese Medicine, 1st edition, January 2020), with one course of treatment lasting 90 days, and a total of one course of treatment was observed). Treatment drug: Chaixiang Jieyu Pills prepared in Example 1, 6g each time, 3 times a day, for 90 consecutive days, taken with warm water after meals.

[0066] 1.6 Efficacy Indicators (1) Comparison of symptom improvement in traditional Chinese medicine Based on the "Guidelines for Clinical Diagnosis and Treatment of Internal Medicine in Traditional Chinese Medicine" (compiled by the China Association of Traditional Chinese Medicine, 1st edition, January 2020), eight symptoms, including depressed mood, suspiciousness and worry, frequent sighing, insomnia, chest and rib distension, fatigue, epigastric fullness and belching, and alternating loose and dry stools, were used as evaluation indicators. The symptoms were scored according to Table 1 below, and the quantitative scores of each symptom were calculated. The results are shown in Table 3 below.

[0067] Table 1. Traditional Chinese Medicine Syndrome Scoring Table

[0068] (2) Evaluation of therapeutic effect The efficacy evaluation was conducted using the TCM efficacy standards. The TCM syndrome efficacy judgment standards were formulated with reference to the relevant contents of the "Guiding Principles for Clinical Research of New Chinese Medicine Drugs" and the "General Principles for Clinical Research of New Chinese Medicine Drugs". The scores were calculated according to the standards in Table 1. The reduction rate was calculated according to Table 2. Then, the corresponding efficacy status of the patients (cured, significantly effective, effective, ineffective) was statistically analyzed to evaluate the efficacy results. The results are shown in Table 4 below.

[0069] Table 2. Criteria for Judging the Efficacy of Traditional Chinese Medicine

[0070] Reduction rate (%) = (Pre-treatment score - Post-treatment score) / Pre-treatment score × 100%.

[0071] 1.7 Statistical Methods SPSS 25.0 software was used for statistical analysis. t-tests were used for continuous data. Count data were expressed as percentages (%) and recorded as mean ± standard deviation (x ± s). A p-value < 0.05 was considered statistically significant, and a p-value < 0.01 was considered statistically significant.

[0072] 2. Results: Table 3 Comparison of TCM symptom quantitative scores of patients

[0073] As shown in Table 3, the patient's TCM symptoms were observed using eight indicators, including low mood, suspiciousness and worry, frequent sighing, insomnia, chest and rib distension, fatigue, epigastric fullness and belching, and sometimes loose and sometimes dry stools. The scores decreased significantly after treatment, and the difference in scores before and after treatment was statistically significant (P<0.05).

[0074] Table 4. Results of Therapeutic Effect Evaluation

[0075] According to the statistics before and after medication, Table 4 above shows that 13 cases were cured, with a cure rate of 21.67%; 30 cases showed significant improvement, with a significant improvement rate of 50%; 14 cases were effective, with an effective rate of 23.33%; and the total effective rate was 95%.

[0076] The above results indicate that the Chaixiang Jieyu Pill of the present invention has the effects of soothing the liver and relieving depression, strengthening the spleen and regulating qi, nourishing blood and calming the mind. It has a significant improving effect on the treatment of depression caused by liver stagnation and spleen deficiency, and malnourishment of the mind, and has good safety.

[0077] Comparative study examples Comparative Example 1 Chaixiang Jieyu Pills: Take 12g of Bupleurum chinense, 4g of Cyperus rotundus (processed with vinegar), 12g of Paeonia lactiflora, 2g of Citrus aurantium (stir-fried with wheat bran), 3g of Rehmannia glutinosa, 12g of Poria cocos, 3g of Albizia julibrissin, 3g of Hordeum vulgare, 3g of Ziziphus jujuba (pitted), and 6g of Glycyrrhiza uralensis. Grind the ten herbs into a fine powder, pass through an 80-mesh sieve, mix well, make into water pills, and dry.

[0078] Comparative Example 2 Chaixiang Jieyu Pills: Take 6g of Bupleurum, 6g of Cyperus rotundus (processed with vinegar), 6g of Paeonia lactiflora, 6g of Citrus aurantium (stir-fried with wheat bran), 6g of Rehmannia glutinosa (processed), 6g of Poria cocos, 6g of Albizia julibrissin bark, 6g of raw malt, 6g of jujube (pitted), and 6g of Glycyrrhiza uralensis. Grind the ten herbs into a fine powder, pass through an 80-mesh sieve, mix well, make into water pills, and dry.

[0079] Comparative Example 3 Chaixiang Jieyu Pills: Take 6g of Bupleurum chinense, 6g of Cyperus rotundus, 6g of Paeonia lactiflora, 6g of Citrus aurantium stir-fried with wheat bran, 6g of Rehmannia glutinosa, 6g of Poria cocos, 6g of Albizia julibrissin, 6g of roasted malt, 6g of jujube (pitted), and 6g of Glycyrrhiza uralensis. Grind the ten herbs into a fine powder, pass through an 80-mesh sieve, mix well, make into water pills, and dry.

[0080] The pills of Comparative Examples 1-3 were tested according to the above method. According to the research and statistics, the total effective rate of Comparative Example 1 was 81.67% (n=60), the total effective rate of Comparative Example 2 was 86.67% (n=60), and the total effective rate of Comparative Example 3 was 85.00% (n=60). The cure rate and the significant efficacy rate were both lower than those of Chaixiang Jieyu Pills in Example 1.

[0081] During the treatment, the patient's vital signs remained normal, liver and kidney function were normal, and no significant adverse reactions occurred.

[0082] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A kind of Chaixiang Jieyu Pill, characterized in that, The ingredients include the following parts by weight: Bupleurum chinense 5-10 parts, Cyperus rotundus 5-10 parts, Paeonia lactiflora 5-15 parts, Citrus aurantium 3-10 parts, Rehmannia glutinosa 5-10 parts, Poria cocos 5-10 parts, Albizia julibrissin flower 5-10 parts, Hordeum vulgare 5-10 parts, Ziziphus jujuba 5-10 parts, Glycyrrhiza uralensis 2-10 parts.

2. The Chaixiang Jieyu Pill according to claim 1, characterized in that, The ingredients include the following parts by weight: Bupleurum chinense 5-8 parts, Cyperus rotundus 5-8 parts, Paeonia lactiflora 5-8 parts, Citrus aurantium 5-8 parts, Rehmannia glutinosa 5-8 parts, Poria cocos 5-8 parts, Albizia julibrissin flower 5-8 parts, Hordeum vulgare 5-8 parts, Ziziphus jujuba 5-8 parts, Glycyrrhiza uralensis 5-8 parts.

3. The Chaixiang Jieyu Pill according to claim 1, characterized in that, The ingredients include the following parts by weight: Bupleurum chinense 6 parts, Cyperus rotundus 6 parts, Paeonia lactiflora 6 parts, Citrus aurantium 6 parts, Rehmannia glutinosa 6 parts, Poria cocos 6 parts, Albizia julibrissin 6 parts, Hordeum vulgare 6 parts, Ziziphus jujuba 6 parts, Glycyrrhiza uralensis 6 parts.

4. The Chaixiang Jieyu Pill according to any one of claims 1-3, characterized in that, The Cyperus rotundus is vinegar-processed Cyperus rotundus; the Citrus aurantium is stir-fried Citrus aurantium with wheat bran; the Rehmannia glutinosa is raw Rehmannia glutinosa; the malt is raw malt; and the jujube is pitted jujube.

5. The preparation method of Chaixiang Jieyu Pills according to any one of claims 1-3, characterized in that, Includes the following steps: The ten herbs, namely Bupleurum, Cyperus, White Peony Root, Immature Bitter Orange, Rehmannia Root, Poria, Albizia Flower, Malt, Jujube, and Licorice, are ground into a fine powder, sieved, mixed evenly, made into water pills, and dried.

6. The preparation method of Chaixiang Jieyu Pill according to claim 5, characterized in that, The sieve mesh size is 80-100 mesh.

7. The use of Chaixiang Jieyu Pills as described in any one of claims 1-3 or prepared by the method of any one of claims 5-6 in the preparation of drugs for liver qi stagnation, liver qi stagnation and spleen deficiency, liver qi stagnation transforming into fire, deficiency of both heart and spleen, disharmony between heart and kidney, and kidney deficiency and liver qi stagnation.

8. The application according to claim 7, characterized in that, The application of the Chaixiang Jieyu Pill in the preparation of medicines for liver stagnation and spleen deficiency, as well as accompanying symptoms such as restlessness, poor appetite due to spleen deficiency, and blood deficiency.

9. The application according to claim 8, characterized in that, The application of the Chaixiang Jieyu Pill in the preparation of medicines for depression caused by liver stagnation, spleen deficiency, and malnourishment of the mind.

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