Traditional Chinese medicine composition for treating common diseases and symptoms of children as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention provides a traditional Chinese medicine composition for treating common diseases and symptoms of children and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. Active components of the traditional Chinese medicine composition comprise the following raw materials in parts by weight: 5-15 parts of honeysuckle; 5 to 15 parts of fructus forsythiae; 10 to 20 parts of radix isatidis; 5-15 parts of radix scutellariae; 3-10 parts of mint; 3-8 parts of liquorice; 5-15 parts of platycodon grandiflorum; 5-15 parts of herba schizonepetae; 5-15 parts of radix puerariae; 3-10 parts of radix bupleuri; 2-8 parts of cicada slough; 3 to 10 parts of fructus arctii; 5-15 parts of flos farfarae; 5-15 parts of ginger processed pinellia; 5 to 15 parts of oyster; 5-15 parts of bighead atractylodes rhizome; 5-15 parts of radix ophiopogonis; 5-15 parts of fructus cannabis; the compound preparation is optimized and adjusted according to the characteristics of children on the basis of a traditional Chinese medicine prescription, and has unique curative effects on common symptoms such as cold, cough, fever, anorexia, vomiting, diarrhea, constipation and development retardation of children. Vitamin C and vitamin E can also be added into the composition to enhance immunity. The traditional Chinese medicine composition is simple in preparation process, can be prepared into various dosage forms, is suitable for children of different ages, and is remarkable in curative effect, short in onset time, convenient to take, free of toxic and side effects, safe and effective.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a traditional Chinese medicine composition for treating common childhood disease symptoms, its preparation method, and its application. Background Technology

[0002] The information disclosed in this background section is intended only to enhance understanding of the overall background of the invention and is not necessarily to be construed as an admission or in any way implying that such information constitutes prior art known to those skilled in the art.

[0003] Common childhood illnesses such as colds, coughs, and fevers account for a large proportion of pediatric outpatient visits, approximately 50-60%. These illnesses not only have a high incidence rate but also tend to recur and are difficult to cure completely, seriously affecting children's physical and mental health and growth and development. At the same time, these symptoms also cause considerable inconvenience to parents' work and daily lives, and some children may even develop a series of other complications as a result.

[0004] From the perspective of Traditional Chinese Medicine (TCM), most common childhood illnesses fall under the category of "external pathogenic factors." The causes can include: 1. Invasion of external pathogens, including the six pathogenic factors such as wind-cold, summer-heat, dampness, and dryness; 2. Dysfunction of the internal organs, such as deficiency of lung and spleen qi, excessive liver fire, and kidney yin deficiency; 3. Improper diet, such as picky eating, excessive consumption of raw or cold foods, or unclean food; 4. Insufficient congenital endowment, delicate physique, and insufficient vital energy. Clinically, symptoms include fever, cough, runny nose, sore throat, vomiting, diarrhea, and constipation. In severe cases, it can affect appetite and sleep, causing restlessness in children and great anxiety for parents who are eager to seek treatment as soon as possible to alleviate the symptoms.

[0005] Currently, treatments for common childhood illnesses mainly fall into two categories: Western medicine and traditional Chinese medicine. Western medicines, such as antipyretics, analgesics, and antibiotics, while fast-acting, have certain side effects, and long-term use may affect children's growth and development, even leading to drug resistance. Traditional Chinese medicines, such as Yinqiao San and Xiaochai Gui antipyretic granules, while having fewer side effects, suffer from poor taste, slow onset of action, and inconvenience in administration, making them difficult for children to accept. Therefore, developing a traditional Chinese medicine composition that can quickly and effectively relieve symptoms, is safe and non-toxic, and easy for children to take, has become one of the important research topics.

[0006] The applicant discovered in preliminary research that a traditional Chinese medicine composition specifically designed for children can be developed by rationally combining traditional Chinese herbs with modern pharmaceutical technology. This composition not only effectively treats symptoms of common childhood illnesses but also boasts advantages such as pleasant taste, rapid onset of action, and high safety. However, how to further optimize the drug formulation to improve efficacy while ensuring safety and ease of administration remains a question worthy of in-depth research. Summary of the Invention

[0007] To address the shortcomings of existing technologies, this invention provides a traditional Chinese medicine composition for treating common childhood illnesses, its preparation method, and its application. This invention is a compound preparation optimized and adjusted for children's characteristics based on traditional Chinese medicine formulas. It has unique efficacy in treating common symptoms in children such as colds, coughs, fever, loss of appetite, vomiting, diarrhea, constipation, and developmental delays. Furthermore, it features a simple preparation process, significant efficacy, short onset of action, convenient administration, no toxic side effects, and is safe and effective.

[0008] To achieve the above objectives, the present invention relates to the following technical solutions:

[0009] In a first aspect, the present invention provides a traditional Chinese medicine composition for treating symptoms of common childhood diseases, the traditional Chinese medicine composition comprising the following raw materials in parts by weight:

[0010] Honeysuckle 5-15 parts, Forsythia 5-15 parts, Isatis root 10-20 parts

[0011] Scutellaria baicalensis 5-15 parts, Mentha haplocalyx 3-10 parts, Glycyrrhiza uralensis 3-8 parts

[0012] Platycodon grandiflorus 5-15 parts, Schizonepeta tenuifolia 5-15 parts, Pueraria lobata 5-15 parts

[0013] Bupleurum 3-10 parts, Cicada molting 2-8 parts, Arctium lappa 3-10 parts

[0014] Coltsfoot flower 5-15 parts, ginger, pinellia 5-15 parts, oyster 5-15 parts

[0015] Atractylodes macrocephala 5-15 parts, Ophiopogon japonicus 5-15 parts, Cannabis sativa 5-15 parts

[0016] 3-8 parts dried tangerine peel, 3-8 parts dried orange peel, 5-15 parts hawthorn

[0017] 5-15 parts of Poria cocos

[0018] A second aspect of the present invention provides a method for preparing the above-mentioned traditional Chinese medicine composition for treating common childhood disease symptoms, the method comprising:

[0019] (1) Wash and dry all the above-mentioned Chinese medicinal materials;

[0020] (2) Weigh out each Chinese medicinal material according to the proportion, and crush the other Chinese medicinal materials into coarse powder of 60-80 mesh except for licorice.

[0021] (3) Slice the licorice root, decoct it twice with water for 1 hour each time, combine the decoctions, filter it, and concentrate the filtrate to an extract with a relative density of 1.10-1.15 (50℃);

[0022] (4) Add 10 times the amount of 50% ethanol to the remaining crude powder of Chinese medicinal materials, reflux extract twice, 2 hours each time, and combine the extracts;

[0023] (5) Concentrate the extract under reduced pressure to a paste with a relative density of 1.20-1.25 (50℃);

[0024] (6) Mix the extracts obtained in steps (3) and (5), stir evenly, dry, pulverize into fine powder, and pass through an 80-mesh sieve;

[0025] (7) Take an appropriate amount of excipients, such as dextrin, sucrose, maltose, etc., mix them evenly with the above fine powder, and make granules or other dosage forms.

[0026] A third aspect of the present invention provides the use of the above-mentioned traditional Chinese medicine composition for treating common childhood disease symptoms in the preparation of pharmaceutical preparations for treating common symptoms in children such as colds, coughs, fevers, anorexia, vomiting, diarrhea, constipation, and developmental delays.

[0027] A fourth aspect of the present invention provides a pharmaceutical preparation for treating symptoms of common childhood diseases, prepared from the traditional Chinese medicine composition and pharmaceutically acceptable excipients.

[0028] The pharmaceutical preparations can be formulated into various dosage forms suitable for children, such as granules, syrups, oral liquids, effervescent tablets, pills, ointments, powders, and soft capsules. Among these, granules and powders can be prepared using wet or dry granulation processes; pills, ointments, and syrups can use monosaccharides or polysaccharides as sweeteners and stabilizers; oral liquids can contain appropriate amounts of preservatives and flavoring agents; effervescent tablets can contain appropriate amounts of foaming agents and disintegrants; and soft capsules can use gelatin or plant-based gums as the encapsulation material.

[0029] The beneficial technical effects of one or more of the above-mentioned technical solutions are as follows: The traditional Chinese medicine composition of the present invention is specifically designed for common childhood disease symptoms, and has the effects of clearing heat and detoxifying, dispelling wind and cold, ventilating the lungs and relieving cough, eliminating phlegm and soothing the throat, and promoting digestion. It has significant therapeutic effects on symptoms such as colds, coughs, fever, loss of appetite, vomiting, diarrhea, constipation, and developmental delays in children. Modern extraction technology is used, which improves the extraction rate of effective components and ensures the stability and consistency of efficacy. The preparation method is simple and easy to implement, suitable for large-scale industrial production. It can be made into various dosage forms suitable for children, improving compliance and safety. It is a pure traditional Chinese medicine preparation, without toxic side effects, safe and effective, and suitable for long-term use by children. In addition, the traditional Chinese medicine composition of the present invention also has the advantages of rapid onset of action, short course of treatment, and low recurrence rate, providing a new option for the treatment of common childhood disease symptoms. Detailed Implementation

[0030] It should be noted that the following detailed description is illustrative and intended to provide further explanation of the invention. Unless otherwise specified, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains.

[0031] It should be noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the scope of exemplary embodiments according to the invention. As used herein, the singular form is intended to include the plural form as well, unless the context clearly indicates otherwise. Furthermore, it should be understood that when the terms "comprising" and / or "including" are used in this specification, they indicate the presence of features, steps, operations, devices, components, and / or combinations thereof.

[0032] As mentioned earlier, common childhood illnesses such as colds, coughs, fever, loss of appetite, vomiting, diarrhea, constipation, and developmental delays account for a large proportion of pediatric outpatient visits, approximately 70-80%. These illnesses not only have a high incidence rate but also tend to recur, making them difficult to cure completely and seriously affecting children's physical and mental health and growth. Current treatment methods have some shortcomings, such as significant side effects from Western medicines and slow onset of action and poor taste of traditional Chinese medicines. Therefore, researching a safe, effective, and child-friendly traditional Chinese medicine composition has become an important research topic.

[0033] In view of this, in one specific embodiment of the present invention, a traditional Chinese medicine composition for treating common childhood disease symptoms is provided, the traditional Chinese medicine composition comprising the following raw materials in parts by weight:

[0034] Honeysuckle 5-15 parts, Forsythia 5-15 parts, Isatis root 10-20 parts

[0035] Scutellaria baicalensis 5-15 parts, Mentha haplocalyx 3-10 parts, Glycyrrhiza uralensis 3-8 parts

[0036] Platycodon grandiflorus 5-15 parts, Schizonepeta tenuifolia 5-15 parts, Pueraria lobata 5-15 parts

[0037] Bupleurum 3-10 parts, Cicada molting 2-8 parts, Arctium lappa 3-10 parts

[0038] Coltsfoot flower 5-15 parts, ginger, pinellia 5-15 parts, oyster 5-15 parts

[0039] Atractylodes macrocephala 5-15 parts, Ophiopogon japonicus 5-15 parts, Cannabis sativa 5-15 parts

[0040] 3-8 parts dried tangerine peel, 3-8 parts dried orange peel, 5-15 parts hawthorn

[0041] 5-15 parts of Poria cocos

[0042] Honeysuckle, forsythia, and isatis root have the effects of clearing heat and detoxifying; scutellaria and mint clear heat and purge fire; licorice harmonizes the effects of other herbs; platycodon and schizonepeta promote lung function and resolve phlegm; kudzu root relieves exterior symptoms and reduces fever; bupleurum soothes the liver and relieves depression; cicada slough and burdock fruit clear heat, detoxify, and disperse wind-heat; tangerine peel and orange peel regulate qi and resolve phlegm; hawthorn promotes digestion and eliminates food stagnation. Coltsfoot flower relieves cough and asthma; ginger and pinellia relieve nausea and vomiting; oyster shell nourishes yin and strengthens yang, promoting growth and development; atractylodes and poria invigorate qi and strengthen the spleen; ophiopogon and hemp seed moisten the intestines and promote bowel movements.

[0043] In another specific embodiment of the present invention,

[0044] The traditional Chinese medicine composition comprises the following raw materials in parts by weight:

[0045] Honeysuckle 8-12 parts, Forsythia 8-12 parts, Isatis root 13-17 parts

[0046] Scutellaria baicalensis 8-12 parts, Mentha haplocalyx 5-8 parts, Glycyrrhiza uralensis 4-6 parts

[0047] Platycodon grandiflorus 8-12 parts, Schizonepeta tenuifolia 8-12 parts, Pueraria lobata 8-12 parts

[0048] Bupleurum 5-8 parts, Cicada molting 3-6 parts, Arctium lappa 5-8 parts

[0049] Coltsfoot flower 5-15 parts, ginger, pinellia 5-15 parts, oyster 5-15 parts

[0050] Atractylodes macrocephala 5-15 parts, Ophiopogon japonicus 5-15 parts, Cannabis sativa 5-15 parts

[0051] 4-6 parts dried tangerine peel, 4-6 parts dried orange peel, 8-12 parts hawthorn

[0052] 5-15 parts of Poria cocos

[0053] In another specific embodiment of the present invention,

[0054] The traditional Chinese medicine composition comprises the following raw materials in parts by weight:

[0055] Honeysuckle 10 parts, Forsythia 10 parts, Isatis root 15 parts

[0056] Scutellaria baicalensis 10 parts, peppermint 6 parts, licorice 5 parts

[0057] 10 parts Platycodon grandiflorus, 10 parts Schizonepeta tenuifolia, 10 parts Pueraria lobata

[0058] Bupleurum 6 parts, Cicada molting 4 parts, Burdock fruit 6 parts

[0059] Coltsfoot flower 5 parts, ginger and pinellia 5 parts, oyster 10 parts

[0060] Atractylodes macrocephala 10 parts, Ophiopogon japonicus 10 parts, Cannabis sativa 10 parts

[0061] 5 parts dried tangerine peel, 5 parts dried orange peel, 10 parts hawthorn

[0062] 10 portions of Poria cocos

[0063] In another specific embodiment of the present invention, a method for preparing the above-mentioned traditional Chinese medicine composition for treating common childhood disease symptoms is provided, the method comprising:

[0064] (1) Wash and dry all the above-mentioned Chinese medicinal materials;

[0065] (2) Weigh out each Chinese medicinal material according to the proportion, and crush the other Chinese medicinal materials into coarse powder of 60-80 mesh except for licorice.

[0066] (3) Slice the licorice root, decoct it twice with water for 1 hour each time, combine the decoctions, filter it, and concentrate the filtrate to an extract with a relative density of 1.10-1.15 (50℃);

[0067] (4) Add 10 times the amount of 50% ethanol to the remaining crude powder of Chinese medicinal materials, reflux extract twice, 2 hours each time, and combine the extracts;

[0068] (5) Concentrate the extract under reduced pressure to a paste with a relative density of 1.20-1.25 (50℃);

[0069] (6) Mix the extracts obtained in steps (3) and (5), stir evenly, dry, pulverize into fine powder, and pass through an 80-mesh sieve;

[0070] (7) Take an appropriate amount of excipients, such as dextrin, sucrose, etc., mix them evenly with the above fine powder, and make granules or other dosage forms.

[0071] In another specific embodiment of the present invention, the above-mentioned traditional Chinese medicine composition for treating common childhood disease symptoms is provided for use in the preparation of pharmaceutical preparations for treating common symptoms in children such as colds, coughs, fevers, anorexia, vomiting, diarrhea, constipation, and developmental delays.

[0072] In another specific embodiment of the present invention, a pharmaceutical preparation for treating common childhood disease symptoms is provided, which is prepared from the traditional Chinese medicine composition and pharmaceutically acceptable excipients.

[0073] The pharmaceutical preparations can be formulated into various dosage forms suitable for children, such as granules, syrups, oral liquids, effervescent tablets, pills, powders, ointments, and soft capsules. Granules can be prepared using wet or dry granulation processes; syrups can use monosaccharides or polysaccharides as sweeteners and stabilizers; oral liquids can contain appropriate amounts of preservatives and flavoring agents; effervescent tablets can contain appropriate amounts of foaming agents and disintegrants; and soft capsules can use gelatin or plant-based gums as the encapsulation material.

[0074] Pharmaceutically acceptable excipients in the pharmaceutical formulation include, but are not limited to: diluents such as sorbitol, mannitol, starch, lactose, maltose, powdered or microcrystalline cellulose, dicalcium phosphate, tricalcium phosphate, sugar, etc.; fillers such as sodium carboxymethyl cellulose, hydroxypropyl cellulose, methyl cellulose, ethyl cellulose, hydroxypropyl methyl cellulose, gelatinized starch, etc.; disintegrants such as dry starch, crospovidone, crospovidone carboxymethyl cellulose sodium, sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, etc.; lubricants such as magnesium stearate, sodium dodecyl sulfate, or micronized silica gel; and other excipients including one or more of binders, flow agents, complexing agents, plasticizers, colorants, sweeteners, viscosity enhancers, preservatives, or antioxidants. The following examples further illustrate the invention but do not constitute a limitation thereof. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the invention.

[0075] Example

[0076] 1. Materials: The traditional Chinese medicine composition was prepared according to the formula in the embodiments; the control drug was commercially available children's cold granules.

[0077] 2. Animals: SPF-grade male ICR mice, weighing 18-22g, provided by the experimental animal center of a medical university.

[0078] 3. Methods and Results

[0079] The drug formulations for each group of mice are shown in Table 1 below. The dosages in Table 1 are single-dose doses and volumes. The drugs were prepared as an equal volume of physiological saline and administered by gavage twice daily for three consecutive days. A total of 10 mice were used in each group. The results are shown in Table 1.

[0080]

[0081] 3.1 Anti-inflammatory effect experiment

[0082] A xylene-induced mouse ear swelling model was used. One hour after the last administration, xylene (20 μl / mouse) was applied to both sides of the right ear of the mice to induce inflammation. One hour after inflammation, the mice were sacrificed, and left and right ear flaps were removed from symmetrical locations on both ears using a 6 mm diameter punch. The weight difference between the left and right ear flaps was calculated as the degree of swelling. The results are shown in Table 2.

[0083]

[0084] Note: Compared with the first group, *P<0.05, **P<0.01. The results show that the traditional Chinese medicine composition of the present invention has a significant inhibitory effect on mouse ear swelling, and the effect is dose-dependent. The inhibitory effect is better than that of the control drug in the 400mg dose group.

[0085] 3.2 Experiment on antipyretic effect

[0086] The yeast pyrogenesis method was used. Mice were subcutaneously injected with 20% yeast suspension (10 ml / kg) to induce pyrogenesis. Rectal temperature was measured 18 h later, and mice with a body temperature increase ≥0.5℃ were selected for the experiment. Rectal temperature was measured at 1, 2, 3, and 4 h after administration. The results are shown in Table 3.

[0087]

[0088] Note: Compared with the first group, *P<0.05, **P<0.01.

[0089] The results showed that the traditional Chinese medicine composition of the present invention has a significant antipyretic effect, which is dose-dependent, and the antipyretic effect is better than that of the control drug in the 400mg dose group.

[0090] 3.3 Antitussive effect experiment The ammonia-induced cough method was used. Mice were placed in a 1L container, and 0.3ml of concentrated ammonia was sprayed in. The number of coughs within 2 minutes was recorded. The above procedure was repeated 2 hours after administration, and the percentage reduction in cough frequency was calculated. The results are shown in Table 4.

[0091]

[0092] Note: Compared with the first group, *P<0.05, **P<0.01. The results showed that the traditional Chinese medicine composition of the present invention has a significant antitussive effect, which is dose-dependent, and the antitussive effect is better than that of the control drug in the 400mg dose group.

[0093] 3.4 Safety Study

[0094] Mice were administered the drug as described above for 14 consecutive days. During this period, their food and water intake, spontaneous activity, stool and urine patterns, and coat color were observed daily. Twenty-four hours after the last administration, mice in each group were sacrificed for complete blood count, liver and kidney function tests, and histopathological observation of major organs.

[0095] The experimental results are as follows:

[0096] No abnormalities were observed in food and water intake, spontaneous activity, stool and urine patterns, or coat color in any group of mice. Complete blood counts and liver and kidney function indicators were all within normal ranges, with no significant differences between groups. Pathological examination revealed no significant abnormalities in major organs such as the heart, liver, and spleen.

[0097] The above results indicate that the traditional Chinese medicine composition of the present invention has good safety within the experimental dosage range.

[0098] 3.5 Clinical Application Research

[0099] Three hundred children aged 3-12 years with colds who visited the outpatient department of a children's hospital were randomly divided into a treatment group and a control group, with 150 cases in each group. The treatment group was given the herbal composition of this invention (100mg, 200mg, and 300mg respectively, for children weighing 10-20kg, 20-30kg, and over 30kg, three times a day), while the control group was given commercially available children's cold granules (according to the instructions for use). The course of treatment for both groups was 5 days. The improvement of clinical symptoms, fever reduction time, and incidence of adverse reactions were observed in both groups. The results are shown in Table 5.

[0100]

[0101] The results showed that the treatment group was superior to the control group in terms of total effective rate, antipyretic time, and incidence of adverse reactions, with statistically significant differences (P<0.05 or P<0.01). The main adverse reactions in the treatment group were mild gastrointestinal reactions, which resolved spontaneously without special treatment.

[0102] In summary, the traditional Chinese medicine composition of the present invention has significant anti-inflammatory, antipyretic, antitussive, antiasthmatic, spleen-strengthening, digestive, antidiarrheal, and growth-promoting effects in children. Its clinical application effect is superior to similar products on the market, and it has good safety and a low incidence of adverse reactions. It is suitable for long-term use in children, acupoint application, and enemas.

[0103] It should be noted that the above examples are only used to illustrate the technical solutions of the present invention and not to limit it. Although the present invention has been described in detail with reference to the given examples, those skilled in the art can modify or make equivalent substitutions to the technical solutions of the present invention as needed, without departing from the spirit and scope of the technical solutions of the present invention.

Claims

1. A traditional Chinese medicine composition for treating symptoms of common childhood diseases, characterized in that, The composition comprises the following raw materials in parts by weight: Honeysuckle 5-15 parts, Forsythia 5-15 parts, Isatis root 10-20 parts, Scutellaria baicalensis 5-15 parts, Peppermint 3-10 parts, Licorice 3-8 parts, Platycodon grandiflorus 5-15 parts, Schizonepeta tenuifolia 5-15 parts, Pueraria lobata 5-15 parts, Bupleurum chinense 3-10 parts, Cicada slough 2-8 parts, Arctium lappa 3-10 parts, Tussilago farfara 5-15 parts; Pinellia ternata 5-15 parts; Oyster shell 5-15 parts; Atractylodes macrocephala 5-15 parts. 5-15 parts of Ophiopogon japonicus; 5-15 parts of hemp seed.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, The composition also comprises the following raw materials in parts by weight: Dandelion 5-15 parts, wild chrysanthemum 3-10 parts, houttuynia cordata 5-15 parts, prunella vulgaris 5-15 parts, scrophularia ningpoensis 5-15 parts, perilla seed 5-15 parts.

3. The traditional Chinese medicine composition as described in claim 1 or 2, characterized in that, The raw materials of the composition are formulated in the following weight ratios: Honeysuckle 10 parts, Forsythia 10 parts, Isatis root 15 parts, Scutellaria baicalensis 10 parts, Peppermint 5 parts Licorice root 5 parts, Platycodon root 10 parts, Schizonepeta tenuifolia root 10 parts, Pueraria root 10 parts, Bupleurum root 5 parts 5 parts cicada molting, 5 parts burdock seed, 5 parts coltsfoot flower, 5 parts ginger-processed pinellia, 10 parts oyster shell, 10 parts atractylodes macrocephala, 10 parts ophiopogon japonicus, 10 parts hemp seed, 10 parts dandelion, 5 parts wild chrysanthemum, 10 parts houttuynia cordata, 5 parts prunella vulgaris, 10 parts scrophularia ningpoensis, and 10 parts perilla seed.

4. The traditional Chinese medicine composition according to any one of claims 1-3, characterized in that, The composition also contains vitamin C and vitamin E in a weight ratio of 1:1 to 1:

5.

5. A method for preparing a traditional Chinese medicine composition according to any one of claims 1-4, characterized in that, Includes the following steps: (1) Clean and dry all the medicinal materials; (2) Grind the dried medicinal materials into a fine powder of 60-100 mesh; (3) Weigh out the powder of each medicinal material according to the formula ratio; (4) Mix all the medicinal powders evenly; (5) Add appropriate excipients to make granules, powders, pills, ointments or other dosage forms.

6. The preparation method according to claim 5, characterized in that, In step (5), the excipient is one or more of sucrose, starch, microcrystalline cellulose, sodium carboxymethyl cellulose, or povidone K30.

7. The preparation method according to claim 5, characterized in that, It also includes the following steps: (6) Dry the obtained granules at 60℃ for 4-6 hours; (7) The dried granules are granulated to a mesh size of 20-40.

8. The preparation method according to claim 5, characterized in that, In step (5), if an oral liquid dosage form is to be prepared, the evenly mixed medicinal powder is added to 10 times the amount of water, decocted twice, 1 hour each time, the filtrates are combined, concentrated under reduced pressure to a relative density of 1.10-1.15 (80℃), and excipients are added to prepare the oral liquid.

9. The use of the traditional Chinese medicine composition according to any one of claims 1-4 in the preparation of a medicine for treating colds, coughs, asthma, fever, sore throat, tonsillitis, anorexia, vomiting, diarrhea, constipation, and developmental delay in children.

10. The application as described in claim 9, characterized in that, The traditional Chinese medicine composition is used to prepare oral liquids, granules, powders, pills, ointments, tablets, capsules, or syrups.

11. A pharmaceutical preparation for treating symptoms of common childhood diseases, characterized in that, It is prepared from the traditional Chinese medicine composition according to any one of claims 1-4.

12. The pharmaceutical formulation according to claim 11, characterized in that, The pharmaceutical preparation is an oral liquid, granule, powder, pill, ointment, tablet, capsule or syrup.

13. The pharmaceutical formulation as described in claim 11, characterized in that, The pharmaceutical preparation also contains pharmaceutically acceptable excipients, which are selected from one or more of the following: diluents, disintegrants, lubricants, binders, sweeteners, flavoring agents, and preservatives.

14. The pharmaceutical formulation according to claim 13, characterized in that, The diluent is lactose, sucrose, maltose, glucose, mannitol, or sorbitol; the disintegrant is sodium carboxymethyl starch, crospovidone, or microcrystalline cellulose; the lubricant is magnesium stearate or talc; the binder is povidone K30 or hydroxypropyl methylcellulose; the sweetener is sucrose, aspartame, or stevia; the flavoring agent is peppermint oil or vanilla extract; and the preservative is potassium sorbate or sodium benzoate.

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