Biomimetic hybrid delivery vehicle targeting hypertrophic scars, method of preparation and use thereof

By constructing a biomimetic hybrid delivery system that combines cationic hyperdeformable liposomes with membrane proteins of hypertrophic scar fibroblasts, the challenges of transdermal and targeted delivery of siRNA in the treatment of hypertrophic scars were solved, achieving highly efficient transfection and therapeutic effects on scar fibroblasts.

CN121588040BActive Publication Date: 2026-06-09JINAN UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JINAN UNIVERSITY
Filing Date
2025-12-05
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

Existing siRNA delivery vectors have limitations in transdermal performance, transfection performance, and targeting performance in the treatment of hypertrophic scars, making it difficult to achieve efficient and precise delivery to scar fibroblasts, resulting in low treatment efficiency and the potential for off-target effects.

Method used

A biomimetic hybrid delivery system was constructed by hybridizing cationic hyperdeformable liposomes with proliferative scar fibroblast membrane proteins to prepare TCPL/HSFs vectors. These vectors were then bound to siRNA targeting the TGF-β1 gene to achieve active targeted delivery, overcome the scar tissue barrier, and realize efficient transfection of siRNA in the dermis.

Benefits of technology

This system significantly inhibits α-SMA expression and ECM deposition, effectively intervenes in the fibrosis process, and features highly efficient transdermal and targeted transfection. It has good biocompatibility and is suitable for the radical treatment of hypertrophic scars and non-invasive gene-targeted therapy for other skin fibrosis or inflammatory diseases.

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Abstract

The application discloses a kind of active targeting hyperplastic scar's biomimetic hybrid delivery vehicle and its preparation method and application.The application uses scar fibroblast membrane protein, cationic delivery vehicle and siRNA and other materials, realizes the hybridization of cell membrane and cationic delivery vehicle by ultrasonic co-extrusion technology, and gives the immune escape and homologous targeting ability of carrier;Efficient loading of TGF-β1 siRNA is realized by using electrostatic self-assembly, so as to construct a biomimetic transdermal delivery system with active targeting characteristics.The biomimetic hybrid delivery vehicle not only provides an innovative approach for the root cause treatment of hyperplastic scar, but also opens up a new way for gene intervention of other skin fibrosis and inflammation-related diseases, and has important clinical translation value.
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