Integrated saliva collection filter

Abstract

The invention belongs to the technical field of medical body fluid sample collection, and provides an integrated saliva collection filter which comprises a collection tube, a sponge rod used for collecting saliva is detachably connected in the collection tube through an extrusion part, a filter assembly is arranged at one end of the collection tube, and the liquid inlet end of the filter assembly corresponds to the sponge rod; the flexible liquid storage mechanism comprises a liquid mixing assembly, the liquid mixing assembly is connected with the collecting pipe through a connecting base, a spring microbead one-way valve assembly and a buffer liquid storage assembly are arranged in the connecting base, and the liquid outlet end of the spring microbead one-way valve assembly is communicated with the liquid mixing assembly; the liquid outlet end of the filtering assembly is communicated with the liquid mixing assembly through a spring microbead one-way valve assembly, and an automatic liquid leakage assembly is arranged between the buffer liquid storage assembly and the filtering assembly. Saliva collection, filtration and buffer solution mixing can be completed in one step, and the device is small in size, convenient to store and transport, capable of being integrally discarded after being used, environmentally friendly and efficient.

Description

Technical Field

[0001] This invention belongs to the field of medical body fluid sample collection technology, and particularly relates to an integrated saliva collection filter. Background Technology

[0002] Saliva collection primarily involves funnels and saliva collectors, and the procedures are often complex, mainly due to variations in the storage methods of the preservation solution. Some saliva collection devices store the preservation solution separately in a tube, requiring six steps: spitting saliva, opening the preservation solution tube cap, pouring in the preservation solution, unscrewing the funnel, closing the preservation cap, and mixing. Others store the preservation solution in the funnel cap or inside the funnel, releasing it by pressing the cap, with five steps: spitting saliva, pressing the funnel cap, unscrewing the funnel, closing the preservation cap, and mixing. A newer design involves pre-filling the collection tube with the preservation solution and sealing it. To use, the screw cap is unscrewed, allowing saliva to drip into the tube from the top. The tube is then tightened and shaken, and the solution is added drop by drop by changing the nozzle. The steps are: spitting saliva, unscrewing the funnel cap, waiting for the saliva to flow down, tightening the funnel cap, mixing, changing the nozzle, and adding the solution.

[0003] In addition, existing integrated saliva collectors that use a funnel to collect saliva have an open collection method that allows saliva to be contaminated by bacteria from the air, object surfaces, and human skin. At the same time, residual saliva can easily stick to the inner wall of the funnel and may leak onto the outer wall of objects or human hands during operation, causing discomfort or making a mess.

[0004] Meanwhile, existing sponge-stick saliva collectors use sealed syringes, primarily in conjunction with additional storage / mixing tubes to mix buffer solutions with saliva. This makes the operation desktop-based, making it more suitable for laboratory use.

[0005] Meanwhile, existing saliva collectors generally adopt an open tube design, allowing the liquid to flow freely downwards along the tube wall due to gravity. This makes the use of the device directional, requiring the user to stand upright or tilt slightly, and to hold it or place it on a table. Due to the limitations of the principle, the tube opening and body cannot be made very thin; otherwise, surface tension will cause blockage and poor airflow, which is more pronounced with highly viscous saliva. Summary of the Invention

[0006] The purpose of this invention is to provide an integrated saliva collection filter to solve the above-mentioned problems.

[0007] To achieve the above objectives, the present invention provides the following solution: an integrated saliva collection filter, comprising: A collection tube, wherein a sponge rod for collecting saliva is detachably connected to the collection tube via a squeezing component, and a filter assembly is provided at one end of the collection tube, with the inlet end of the filter assembly corresponding to the sponge rod; A flexible liquid storage mechanism includes a liquid mixing component connected to a collection tube via a connector. The connector houses a spring-loaded microbead one-way valve assembly and a buffer solution storage assembly. The outlet of the spring-loaded microbead one-way valve assembly is connected to the liquid mixing component. The outlet of the filtration assembly is also connected to the liquid mixing component via the spring-loaded microbead one-way valve assembly. An automatic leakage assembly is provided between the buffer solution storage assembly and the filtration assembly. This automatic leakage assembly allows buffer solution from the buffer solution storage assembly to enter the liquid mixing component when the filtration assembly opens the spring-loaded microbead one-way valve assembly.

[0008] Preferably, the filtration assembly includes a filter seat slidably connected in the collection tube, with a flow guide tube connected to the end of the filter seat away from the sponge rod, a first opening provided at the end of the filter seat near the sponge rod, a first spring abutting between the side of the filter seat near the flow guide tube and the collection tube, the flow guide tube penetrating the collection tube and correspondingly arranged with the flexible liquid storage mechanism, and two sets of supporting filter screens fixedly connected inside the filter seat along the axis of the collection tube, with a filter membrane abutting between the two supporting filter screens.

[0009] Preferably, the inner wall of the flow guide tube is fixedly connected to a top rod by a plurality of first support rods. The end of the top rod away from the first support rod extends out of the end of the flow guide tube away from the filter seat and is correspondingly arranged with the spring microbead one-way valve assembly.

[0010] Preferably, the spring microbead one-way valve assembly includes a guide tube fixedly connected in the connecting seat, the liquid outlet end of the guide tube is connected to the liquid mixing assembly, the liquid inlet end of the guide tube is connected to the liquid outlet end of the guide tube, and a one-way valve is provided in the guide tube. The one-way valve is used to allow saliva to enter the liquid mixing assembly and prevent liquid backflow in the liquid mixing assembly.

[0011] Preferably, the one-way valve includes a glass bead, which is slidably connected inside the guide tube. A second spring abuts between the glass bead and the liquid outlet end of the guide tube, and the glass bead abuts against the liquid inlet end of the guide tube. The push rod is correspondingly arranged on the side of the glass bead away from the second spring.

[0012] Preferably, a plurality of second support rods are fixedly connected to one end of the guide tube near the liquid mixing component, and a stabilizing rod is fixedly connected to the plurality of second support rods. The end of the second spring away from the glass bead is fixedly sleeved on the stabilizing rod.

[0013] Preferably, the buffer storage assembly includes a buffer tank fixedly connected in the connector, the bottom of the buffer tank is provided with a second opening for communicating with the liquid mixing assembly, a bottom cover is detachably connected to the second opening, one side of the bottom cover is hinged to the buffer tank, and the other end of the bottom cover is provided between the bottom cover and the flow guide tube with the automatic leakage assembly.

[0014] Preferably, the automatic leakage assembly includes a first side plate fixedly connected to the side of the bottom cover away from the hinge end and a second side plate fixedly connected to the side wall of the guide tube. The second side plate is located inside the connecting seat, and a connecting rod is slidably connected inside the connecting seat. The two ends of the connecting rod are respectively corresponding to the first side plate and the second side plate.

[0015] Preferably, the liquid mixing assembly includes a tail housing fixedly connected to the end of the connector away from the collection tube, and a head housing fixedly connected to the end of the tail housing away from the connector via an annular folded wall, and a liquid outlet is provided on the head housing.

[0016] Preferably, the liquid outlet includes micropores formed on the head housing, and a thin film is detachably adhered to the outer wall of the head housing for sealing the micropores.

[0017] Compared with existing technologies, this invention has the following advantages and technical effects: This invention utilizes a squeezing device to compress the saliva collected by the sponge rod inside the collection tube, avoiding the generation of large amounts of saliva foam that can occur when directly collecting saliva by spitting it out, resulting in insufficient saliva collection and leakage. It also eliminates the waiting time for gravity-fed flow, effectively preventing contamination. Furthermore, it includes a built-in buffer solution, eliminating the need to mix saliva from two different containers. By adopting an integrated design, the three processes of saliva collection, filtration, and buffer mixing are completed in one step, simplifying the operation. This invention is small in size, requires little space for storage and transportation, and can be discarded entirely after use, thus helping to avoid environmental pollution. Attached Figure Description

[0018] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0019] Figure 1 This is a schematic diagram of the saliva collection filter of the present invention; Figure 2 for Figure 1 Enlarged view of part A in the image; Figure 3 This is a schematic diagram of the liquid mixing component of the present invention; Figure 4 This is a schematic diagram of the liquid mixing component according to Embodiment 2 of the present invention; Figure 5 This is a schematic diagram of the liquid mixing component according to Embodiment 3 of the present invention; The components are as follows: 1. Collection tube; 2. Sponge rod slot; 3. Sealing ring; 4. Push rod; 5. Connecting seat; 6. Liquid mixing assembly; 7. Filter assembly; 8. Buffer solution storage assembly; 9. Spring microbead one-way valve assembly; 10. Sponge rod; 61. Head shell; 62. Annular folded wall; 63. Tail shell; 64. Micropore; 65. Protrusion; 66. Straight tube section; 67. Frustum-shaped shell; 71. Filter seat; 72. Supporting filter screen; 73. Filter membrane; 74. First spring; 75. Guide tube; 76. First support rod; 77. Top rod; 81. Buffer solution storage tank; 82. Bottom cover; 83. First side plate; 84. Connecting rod; 85. Second side plate; 91. Guide tube; 92. Glass bead; 93. Second spring; 94. Stabilizing rod; 95. Second support rod. Detailed Implementation

[0020] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0021] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0022] Example 1: Reference Figures 1-3 This invention provides an integrated saliva collection filter, comprising: Collection tube 1, a sponge rod 10 for collecting saliva is detachably connected inside the collection tube 1 via a squeezing member, and a filter assembly 7 is provided at one end of the collection tube 1, with the liquid inlet end of the filter assembly 7 corresponding to the sponge rod 10. The flexible liquid storage mechanism includes a liquid mixing component 6, which is connected to the collection tube 1 via a connecting seat 5. The connecting seat 5 is equipped with a spring microbead one-way valve assembly 9 and a buffer storage component 8. The outlet end of the spring microbead one-way valve assembly 9 is connected to the liquid mixing component 6. The outlet end of the filter assembly 7 is connected to the liquid mixing component 6 by opening the inlet end of the spring microbead one-way valve assembly 9. An automatic leakage component is provided between the buffer storage component 8 and the filter assembly 7. The automatic leakage component is used to allow the buffer solution in the buffer storage component 8 to enter the liquid mixing component 6 when the spring microbead one-way valve assembly 9 is opened in the filter assembly 7.

[0023] The main function of the extruder is to press the sponge rod 10 against the surface of the filter assembly 7, causing the saliva collected in the sponge rod 10 to be released. The main function of the filter assembly 7 is to process the saliva and remove different saliva mucus substances. The main function of the spring microbead one-way valve assembly 9 is to prevent the liquid in the liquid mixing assembly 6 from flowing back into the collection tube 1 and to allow the saliva to smoothly enter the liquid mixing assembly 6 during the saliva collection process. The main function of the buffer storage assembly 8 is to store the buffer solution. The main function of the automatic leakage assembly is to inject saliva into the liquid mixing assembly 6 so that the buffer solution in the buffer storage assembly 8 automatically flows into the liquid mixing assembly 6, thereby achieving the mixing of saliva and buffer solution.

[0024] Overall, this invention utilizes a squeezing device to compress the sponge rod collecting saliva within the collection tube, avoiding the excessive saliva foam generated by directly spitting out saliva, which can lead to insufficient saliva collection and leakage. It also eliminates the waiting time for gravity-fed saliva, effectively preventing contamination. Furthermore, it includes a built-in buffer solution, eliminating the need to mix saliva from two different containers. This integrated design achieves the three processes of saliva collection, filtration, and buffer mixing in a single operation, simplifying the process. The invention is small in size, requiring minimal storage and transportation space, and can be discarded entirely after use, thus minimizing environmental pollution.

[0025] In a further optimized design, the filter assembly 7 includes a filter seat 71 slidably connected in the collection tube 1. The end of the filter seat 71 away from the sponge rod 10 is connected to a flow guide tube 75. The end of the filter seat 71 near the sponge rod 10 is provided with a first opening. A first spring 74 is abutted between the side of the filter seat 71 near the flow guide tube 75 and the collection tube 1. The flow guide tube 75 passes through the collection tube 1 and is correspondingly arranged with the flexible liquid storage mechanism. Two sets of support filter screens 72 are fixedly connected inside the filter seat 71 along the axis of the collection tube 1. A filter membrane 73 abuts between the two support filter screens 72.

[0026] The support filter 72 is made of metal to withstand the mechanical pressure generated by squeezing the sponge rod 10. The filter membrane 73 is a hydrophilic filter membrane, whose main function is to treat saliva using hydrophilic filter membranes with different pore sizes to remove different saliva mucus substances. In this embodiment, a PES polyethersulfone hydrophilic filter membrane is used.

[0027] In a further optimized design, the inner wall of the flow guide tube 75 is fixedly connected to a top rod 77 by several first support rods 76. The end of the top rod 77 away from the first support rods 76 extends out of the end of the flow guide tube 75 away from the filter seat 71 and is correspondingly set with the spring microbead one-way valve assembly 9.

[0028] like Figure 1 and Figure 2 As shown, during the process of the sponge rod 10 pushing the upper support filter 72, the filter seat 71 moves downward under the squeezing force, driving the guide tube 75 downward as well, causing the push rod 77 to move towards the spring microbead one-way valve assembly 9 and open it. After the filter seat 71 abuts against the bottom of the collection tube 1, the saliva in the sponge rod 10 can be separated under the continuous squeezing force, passing through the filter membrane 73 and entering the guide tube 75 and flowing into the spring microbead one-way valve assembly 9. After the squeezing is completed, the filter seat 71 can move upward and reset under the elastic force of the first spring 74. At this time, the push rod 77 separates from the spring microbead one-way valve assembly 9.

[0029] To further optimize the design, in this embodiment, three sets of first support rods 76 are provided. The three sets of first support rods 76 are fixedly connected at equal intervals in the guide tube 75, which can support the top rod 77 while avoiding significant impact on the flow of saliva.

[0030] Further optimization of the scheme: the spring microbead one-way valve assembly 9 includes a guide tube 91 fixedly connected in the connecting seat 5. The liquid outlet end of the guide tube 91 is connected to the liquid mixing assembly 6, and the liquid inlet end of the guide tube 91 is connected to the liquid outlet end of the guide tube 75. A one-way valve is provided in the guide tube 91. The one-way valve is used to allow saliva to enter the liquid mixing assembly 6 and prevent the liquid in the liquid mixing assembly 6 from flowing back.

[0031] Further optimize the plan, such as Figure 2 As shown, the outer diameter of the guide tube 75 is smaller than the inner diameter of the guide tube 91. When the guide tube 75 moves downward, the push rod 77, because it extends out of the guide tube 75, first contacts the glass bead 92 and presses the glass bead 92 downward. Then the guide tube 75 extends into the guide tube 91. The push rod 77 can prevent the bottom outlet of the guide tube 75 from sticking to the glass bead 92, ensuring the smooth flow of saliva.

[0032] The scheme is further optimized. The one-way valve includes a glass bead 92, which is slidably connected in the guide tube 91. A second spring 93 is abutted between the glass bead 92 and the liquid outlet end of the guide tube 91. The glass bead 92 abuts against the liquid inlet end of the guide tube 91. The push rod 77 is correspondingly set on the side of the glass bead 92 away from the second spring 93.

[0033] like Figure 2 As shown, during the process of the push rod 77 pushing the glass bead 92 downward as the guide tube 75 moves downward, the glass bead 92 moves downward and compresses the second spring 93. The glass bead 92 separates from the head of the guide tube 91, and the saliva flows out of the guide tube 75 and directly enters the guide tube 91, and flows into the liquid mixing assembly 6 along the guide tube 91.

[0034] When the saliva collection is complete and the sponge rod 10 is no longer squeezed, the filter seat 71 moves upward and resets under the elastic force of the first spring 74. The top rod 77 separates from the glass bead 92, and the glass bead 92 moves upward under the elastic force of the second spring 93, re-abutting against the head of the guide tube 91 to seal the guide tube 91 and prevent liquid backflow in the liquid mixing assembly 6.

[0035] In a further optimized design, a number of second support rods 95 are fixedly connected to one end of the guide tube 91 near the liquid mixing component 6, and a stabilizing rod 94 is fixedly connected to the number of second support rods 95. The end of the second spring 93 away from the glass bead 92 is fixedly sleeved on the stabilizing rod 94.

[0036] like Figure 2 As shown, in this embodiment, three sets of second support rods 95 are provided. The three sets of second support rods 95 are fixedly connected in the guide tube 91 at equal intervals. While supporting the stabilizing rod 94, they can also avoid significantly affecting the flow of saliva.

[0037] In a further optimized design, the buffer storage assembly 8 includes a buffer storage tank 81 fixedly connected to the connector 5. The bottom of the buffer storage tank 81 is provided with a second opening for communicating with the liquid mixing assembly 6. A bottom cover 82 is detachably connected to the second opening. One side of the bottom cover 82 is hinged to the buffer storage tank 81, and an automatic leakage assembly is provided between the other end of the bottom cover 82 and the guide tube 75.

[0038] Further optimization of the scheme: the automatic leakage component includes a first side plate 83 fixedly connected to the side of the bottom cover 82 away from the hinge end and a second side plate 85 fixedly connected to the side wall of the guide tube 75. The second side plate 85 is located in the connecting seat 5. A connecting rod 84 is slidably connected in the connecting seat 5. The two ends of the connecting rod 84 are respectively set to correspond to the first side plate 83 and the second side plate 85.

[0039] like Figure 2As shown, the buffer solution tank 81 stores buffer solution. During the downward movement of the filter seat 71, the second side plate 85 moves down together and pushes the connecting rod 84 downward. The connecting rod 84 moves down and pushes the first side plate 83, opening the bottom cover 82 towards the inside of the liquid mixing assembly 6, so that the stored buffer solution flows into the liquid mixing assembly 6.

[0040] The solution is further optimized. The liquid mixing component 6 includes a tail housing 63 fixedly connected to the end of the connecting seat 5 away from the collection tube 1. The end of the tail housing 63 away from the connecting seat 5 is fixedly connected to a head housing 61 through an annular folding wall 62. A liquid outlet is provided on the head housing 61.

[0041] In this embodiment, both the head shell 61 and the tail shell 63 are made of flexible materials such as silicone. At the same time, in order to ensure that the annular folding wall 62 unfolds smoothly, the wall thickness of the annular folding wall 62 is less than the wall thickness of the head shell 61 and the tail shell 63, and it can be made of silicone with a thickness of 0.5mm.

[0042] like Figure 1 and Figure 3 As shown, in the storage state, the annular folded wall 62 is compressed, and the head shell 61 and tail shell 63 are close to each other, which can significantly reduce the space required for storage. During the process of squeezing the sponge rod 10 to collect saliva, air and precipitated saliva will cause the annular folded wall 62 to unfold longitudinally, expanding the internal volume and creating space to accommodate the buffer solution and injected saliva.

[0043] The solution is further optimized so that the liquid outlet includes micropores 64 formed on the head housing 61, and a thin film is detachably adhered to the outer wall of the head housing 61 to seal the micropores 64.

[0044] like Figure 3 As shown, tear off the tearable film to expose the micropore 64. Align the micropore 64 with the target object such as the test strip used for detection, and squeeze the head housing 61 with your hand in the direction of the collection tube 1 to squeeze out the mixed solution in the liquid mixing component 6.

[0045] The scheme is further optimized. The extrusion component includes a sponge rod slot 2. One end of the sponge rod slot 2 is inserted into a sponge rod 10 through a groove, and the other end is fixedly connected to a push rod 4. The end of the collection tube 1 away from the filter component 7 is open so that the sponge rod slot 2 can be inserted into or pulled out of the collection tube 1.

[0046] Further optimization of the design: several sealing rings 3 are fixedly connected to the outer wall of the sponge rod slot 2, and the sealing rings 3 fit into the interior of the collection tube 1.

[0047] The working process of this embodiment is as follows: In the initial state, the glass bead 92 is in contact with the head of the guide tube 91, and the micropore 64 is sealed by the thin film adhesive.

[0048] When saliva collection is required, pull out the push rod 4, hold the sponge stick 10 inside the mouth or chew for 5 minutes to collect enough saliva.

[0049] After saliva collection, the sponge rod slot 2 is placed into the collection tube 1, and the push rod 4 is squeezed. At this time, the sponge rod 10 is squeezed, causing saliva to be expelled and pushing the filter seat 71 downward, so that the guide tube 75 is inserted into the guide tube 91. At the same time, the push rod pushes the glass bead 92 away from the guide tube 91. Under pressure, the saliva passes through the filter membrane 73 and finally enters the liquid mixing component 6. At the same time, the bottom cover 82 is opened, and the buffer solution mixes with the saliva. The entry of saliva and gas causes the annular folded wall 62 to unfold longitudinally, expanding the internal volume and creating space to accommodate the injected saliva, making it possible to store and mix the saliva.

[0050] When the squeezing of the sponge rod 10 stops, since there is no external force and the micropores 64 are sealed by the thin film adhesive, the glass bead 92 re-abuts against the guide tube 91. Therefore, the solution in the liquid mixing component 6 is in a sealed state, and the saliva sample can be stored and transported in this state.

[0051] Remove the adhesive film to expose the micropore 64. Align the micropore 64 with the target object such as the test strip used for detection. Press the head shell 61 with your hand in the direction of the collection tube 1 to squeeze out the mixed solution in the flexible liquid storage head cavity.

[0052] Example 2: The only difference between this embodiment and Embodiment 1 is that a protrusion 65 is connected to the side wall of the head shell 61 to replace the micropore 64.

[0053] like Figure 4 As shown, in this embodiment, the head housing 61 has a protrusion 65 connected to one end away from the tail housing 63. When it is necessary to squeeze out the mixture in the liquid mixing component 6, the protrusion 65 can be cut off, and then the head housing 61 can be squeezed in the direction of the collection tube 1 to make the mixture flow out.

[0054] Example 3: The only difference between this embodiment and Embodiment 1 is that, Figure 5 As shown, the liquid mixing assembly 6 includes a straight pipe section 66 fixedly connected to the end of the connecting seat 5 away from the collection tube 1. A frustum-shaped housing 67 is fixedly connected to the end of the straight pipe section 66 away from the connecting seat 5. A micropore 64 is provided at the bottom of the frustum-shaped housing 67.

[0055] In this embodiment, the straight pipe section 66 and the frustum-shaped shell 67 are made of flexible materials such as silicone. The frustum-shaped shell 67 can provide sufficient liquid mixing space. By squeezing the straight pipe section 66 and the frustum-shaped shell 67, the mixture can flow out from the micropores 64 at the bottom.

[0056] In the description of this invention, it should be understood that the terms "longitudinal", "lateral", "up", "down", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this invention, and are not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this invention.

[0057] The embodiments described above are merely preferred embodiments of the present invention and are not intended to limit the scope of the present invention. Various modifications and improvements made by those skilled in the art to the technical solutions of the present invention without departing from the spirit of the present invention should fall within the protection scope defined by the claims of the present invention.

Claims

1. An integrated saliva collection filter, comprising: The utility model relates to a saliva collection device, comprising: a collection tube (1) having a sponge rod (10) for collecting saliva detachably connected by a pressing piece, one end of the collection tube (1) being provided with a filter assembly (7), the liquid inlet end of the filter assembly (7) being correspondingly provided with the sponge rod (10); a flexible liquid storage mechanism comprising a liquid mixing assembly (6) connected with the collection tube (1) through a connecting seat (5), the connecting seat (5) being provided with a spring micro-bead one-way valve assembly (9) and a buffer solution storage assembly (8), the liquid outlet end of the spring micro-bead one-way valve assembly (9) being communicated with the liquid mixing assembly (6), the liquid outlet end of the filter assembly (7) being communicated with the liquid mixing assembly (6) through the spring micro-bead one-way valve assembly (9), and an automatic liquid leakage assembly being arranged between the buffer solution storage assembly (8) and the filter assembly (7), the automatic liquid leakage assembly being used for making the buffer solution in the buffer solution storage assembly (8) enter the liquid mixing assembly (6) when the filter assembly (7) opens the spring micro-bead one-way valve assembly (9).

2. The integrated saliva collection filter of claim 1, wherein: The filter assembly (7) comprises a filter seat (71) slidingly connected in the collection tube (1), the end of the filter seat (71) away from the sponge rod (10) being communicated with a flow guide capillary tube (75), the end of the filter seat (71) close to the sponge rod (10) being provided with a first opening, the side of the filter seat (71) close to the flow guide capillary tube (75) being abutted with a first spring (74) between the filter seat (71) and the collection tube (1), the flow guide capillary tube (75) penetrating through the collection tube (1) and being correspondingly provided with the flexible liquid storage mechanism, and two groups of support filter screens (72) being fixedly connected in the filter seat (71) along the axis of the collection tube (1), the support filter screens (72) being abutted with a filter membrane (73) between them.

3. The integrated saliva collection filter of claim 2, wherein: The inner wall of the flow guide capillary tube (75) is fixedly connected with a jack (77) through a plurality of first support rods (76), the end of the jack (77) away from the first support rods (76) extending out of the end of the flow guide capillary tube (75) away from the filter seat (71) and being correspondingly provided with the spring micro-bead one-way valve assembly (9).

4. The integrated saliva collection filter of claim 3, wherein: The spring micro-bead one-way valve assembly (9) comprises a flow guide tube (91) fixedly connected in the connecting seat (5), the liquid outlet end of the flow guide tube (91) being communicated with the liquid mixing assembly (6), the liquid inlet end of the flow guide tube (91) being communicated with the liquid outlet end of the flow guide capillary tube (75), and a one-way valve piece being arranged in the flow guide tube (91), the one-way valve piece being used for making saliva enter the liquid mixing assembly (6) and avoiding the liquid in the liquid mixing assembly (6) backflowing.

5. The integrated saliva collection filter of claim 4, wherein: The one-way valve piece includes a glass bead (92) which is slidingly connected in the flow guide pipe (91), the glass bead (92) is in abutment with the liquid outlet end of the flow guide pipe (91) through a second spring (93), the glass bead (92) is in abutment with the liquid inlet end of the flow guide pipe (91), and the top rod (77) is correspondingly arranged on the side of the glass bead (92) away from the second spring (93).

6. The integrated saliva collection filter of claim 5, wherein: A plurality of second supporting rods (95) are fixedly connected to the end of the flow guide pipe (91) close to the liquid mixing assembly (6), a stabilizing rod (94) is fixedly connected to the second supporting rods (95), and the end of the second spring (93) away from the glass bead (92) is fixedly sleeved on the stabilizing rod (94).

7. The integrated saliva collection filter of claim 2, wherein: The buffer solution storage assembly (8) includes a buffer solution storage tank (81) fixedly connected in the connecting seat (5), the bottom of the buffer solution storage tank (81) is provided with a second opening for communication with the liquid mixing assembly (6), a bottom cover (82) is detachably connected in the second opening, one side of the bottom cover (82) is hingedly connected with the buffer solution storage tank (81), and the other end of the bottom cover (82) and the flow guide tube (75) are provided with the automatic liquid leakage assembly.

8. The integrated saliva collection filter of claim 7, wherein: The automatic liquid leakage assembly includes a first side plate (83) fixedly connected to the side of the bottom cover (82) away from the hinged end and a second side plate (85) fixedly connected to the side wall of the flow guide tube (75), the second side plate (85) is located in the connecting seat (5), a connecting rod (84) is slidingly connected in the connecting seat (5), and the two ends of the connecting rod (84) are correspondingly arranged with the first side plate (83) and the second side plate (85).

9. The integrated saliva collection filter of claim 1, wherein: The liquid mixing assembly (6) includes a tail shell (63) fixedly connected to the end of the connecting seat (5) away from the collection tube (1), the end of the tail shell (63) away from the connecting seat (5) is fixedly connected with a head shell (61) through an annular folding wall (62), and the head shell (61) is provided with a liquid outlet.

10. The integrated saliva collection filter of claim 9, wherein: The liquid outlet includes a micropore (64) formed in the head shell (61), a film is detachably attached to the outer wall of the head shell (61), and the film is used for plugging the micropore (64).

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