3D printing double-layer gradient composite scaffold as well as preparation method and application thereof

By using multi-nozzle collaborative 3D printing technology to prepare a double-layer gradient composite scaffold, and utilizing dual drug-loaded nanoparticles to achieve sequential drug release, the problems of complexity in traditional scaffold construction and weak interfacial bonding were solved, realizing integrated and efficient repair of osteochondral defects.

CN121623013APending Publication Date: 2026-03-10DONGHUA UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-12-23
Publication Date
2026-03-10

AI Technical Summary

Technical Problem

Traditional methods for constructing osteocartilage repair scaffolds are complex, and the interfacial bonding between bone and cartilage is weak, making it difficult to meet application requirements. Furthermore, the use of 3D printing technology for integrated repair of osteocartilage defects still faces challenges in inducing seed cell differentiation and drug delivery.

Method used

Using multi-nozzle collaborative 3D bioprinting technology, cartilage repair layer and subchondral bone repair layer were prepared separately. Drug release was achieved through dual-drug-loaded nanoparticles to promote chondrogenic and osteogenic differentiation of cells. An integrated osteochondral repair scaffold was constructed through a gradient structure.

Benefits of technology

It achieves integrated and efficient repair of osteocartilage defects, improves the integrity and structural stability of the scaffold, promotes cell differentiation and angiogenesis, and meets the repair needs of osteocartilage defects.

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Abstract

The invention provides a 3D printing double-layer gradient composite scaffold and a preparation method and application thereof, the 3D printing double-layer gradient composite scaffold is prepared by adopting a multi-nozzle collaborative printing technology of a 3D printing system, and the 3D printing double-layer gradient composite scaffold comprises a cartilage repair layer and a subchondral bone repair layer. Wherein the cartilage repair layer and the subchondral bone repair layer are respectively prepared by cooperatively printing a thermoplastic polymer material and a photocurable natural polymer material mixed with cells and double drug-loaded nanoparticles through double nozzles of a 3D printing system. The distance between the printed microwires of the cartilage repair layer is smaller than that between the printed microwires of the subchondral bone repair layer. The double-layer gradient composite scaffold is integrally prepared by using a multi-nozzle collaborative printing technology of a 3D printing system, has good mechanical strength and biocompatibility, and can realize integrated repair of osteochondral defects.
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