Depression-relieving and mind-tranquilizing ointment and preparation method thereof

Abstract

The invention discloses equipment for preparing ointment, and particularly relates to depression-relieving and mind-tranquilizing ointment and a preparation method thereof. The depression-relieving and mind-tranquilizing ointment comprises the following Chinese herbal medicine components: 5-7 parts of radix bupleuri; 10 to 20 parts of semen ziziphi spinosae; 5 to 10 parts of polygala tenuifolia; 3-5 parts of licorice root; 5 to 10 parts of rhizoma cyperi; 5-7 parts of radix curcumae; 3-10 parts of rhizoma acori graminei; 5-7 parts of schisandra chinensis; 1-6 parts of salvia miltiorrhiza; 5-15 parts of light wheat; 4-6 parts of fingered citron; 3-7 parts of rose flower; 1-5 parts of ganoderma lucidum; and 1-3 parts of lotus plumule. In the formula design, four core medicinal materials of radix bupleuri, spina date seed, polygala tenuifolia and liquorice are reserved to ensure the basic effects of soothing liver-qi stagnation and tranquilizing mind by nourishing the heart, and other medicinal materials are components which are supported by modern pharmacological research and have strong compatibility synergy, such as rhizoma cyperi, radix curcumae, rhizoma acori graminei, schisandra chinensis, salvia miltiorrhiza, light wheat, fingered citron, rose, lucid ganoderma and lotus plumule. The multi-target effect of the whole prescription on the aspects of adjusting emotion, improving sleep and relieving anxiety is enhanced, and the traditional Chinese medicine composition is particularly suitable for sub-health people with mild and moderate emotional disorder.

Description

Technical Field

[0001] This invention relates to the field of ointment preparation technology, and in particular to an antidepressant and calming ointment and its preparation method. Background Technology

[0002] With the fast pace and increasing pressure of modern life, sub-health conditions such as emotional imbalance are becoming increasingly common, mainly manifested as symptoms such as low mood, anxiety, insomnia, and poor concentration. Traditional Chinese medicine believes that these problems are mostly caused by stagnation of liver qi and malnourishment of the heart and spirit, and treatment emphasizes soothing the liver, relieving stagnation, nourishing the heart, and calming the mind. Traditional Chinese medicine compound formulas such as Xiaoyao San and Suanzaoren Tang are widely used in clinical practice, but they are mostly in the form of decoctions or pills, which have problems such as poor taste, inconvenience of administration, and poor stability, making it difficult to meet the needs of modern people for convenience and compliance.

[0003] In recent years, topical ointments have gradually become a new direction in the research and development of traditional Chinese medicine preparations due to their advantages such as transdermal absorption, ease of use, and avoidance of the first-pass effect. However, existing ointments mostly use traditional bases such as honey, beeswax, and olive oil, which have defects such as high glycemic index, easy oxidation and deterioration, greasy feel, and insufficient stability. Moreover, the high-temperature extraction process often leads to a large loss of volatile and heat-sensitive active ingredients (such as aromatics and saponins), affecting efficacy.

[0004] Therefore, there is an urgent need to develop a new type of traditional Chinese medicine ointment with a scientifically formulated composition, advanced matrix, reasonable process, good stability, and suitable for external use, so as to improve the patient's experience and safety while ensuring efficacy. Summary of the Invention

[0005] In order to solve the problems existing in the prior art, the present invention provides a remedy for calming the mind and relieving depression, and a method for preparing the same, so as to solve the current technical problems.

[0006] The technical solution adopted by this invention to solve its technical problem is: This invention provides a remedy for relieving depression and calming the mind, and its preparation method, comprising the following traditional Chinese herbal medicine components: Bupleurum: 5-7 parts; Ziziphus jujuba seed: 10-20 parts; Polygala tenuifolia: 5-10 parts; Glycyrrhiza uralensis: 3-5 parts; Cyperus rotundus: 5-10 parts; Curcuma longa: 5-7 parts; Acorus tatarinowii: 3-10 parts; Schisandra chinensis: 5-7 parts; Salvia miltiorrhiza: 1-6 parts; Triticum aestivum: 5-15 parts; Citrus medica: 4-6 parts; Rosa rugosa: 3-7 parts; Ganoderma lucidum: 1-5 parts; Nelumbo nucifera seed heart: 1-3 parts.

[0007] Preferably, the matrix components include the following: maltitol: 50-120 parts; cocoa butter: 5-10 parts; jojoba oil: 50-150 parts; vitamin E: 1-3 parts.

[0008] Preferably, the preparation method includes the following: Step 1: Pre-treatment of Chinese herbal medicines: Grind the Chinese herbal medicines into powder and sieve them; Step 2: Low-temperature water extraction and vacuum concentration: Mix all the medicinal powders except for the rose petals evenly, put them into a stainless steel container, add purified water to soak, and concentrate under vacuum. Step 3: Post-processing of aromatic herbs: Add rose powder to the concentrated extract produced in Step 2, heat and stir to fully dissolve the aromatic components; Step 4: Prepare the ointment base: Place maltitol and jojoba oil in a pot and heat in a water bath to dissolve them; then add cocoa butter and stir to combine. Step 5: Mixing and Homogenizing: Preheat the concentrated extract produced in Step 3 and add it dropwise to the matrix liquid produced in Step 4 to mix and prepare the paste; Step 6: Filling and storage: Fill the ointment into sterile brown glass bottles.

[0009] The beneficial effects of this invention are: Firstly, in terms of formulation design, the four core medicinal materials of Bupleurum, Ziziphus jujuba seed, Polygala tenuifolia, and Glycyrrhiza uralensis are retained to ensure the basic effects of soothing the liver and relieving depression, nourishing the heart and calming the mind. The remaining medicinal materials are components supported by modern pharmacological research and have strong compatibility and synergistic effects, such as Cyperus rotundus, Curcuma longa, Acorus tatarinowii, Schisandra chinensis, Salvia miltiorrhiza, Triticum aestivum, Citrus medica, Rosa rugosa, Ganoderma lucidum, and Nelumbo nucifera heart. This enhances the multi-target effects of the overall formula in regulating emotions, improving sleep, and relieving anxiety, and is especially suitable for people in a sub-healthy state with mild to moderate emotional disorders.

[0010] Secondly, the matrix system abandons the traditional honey-beeswax-olive oil combination and innovatively adopts a composite matrix of maltitol-cocoa butter-jojoba oil-vitamin E. This matrix not only has good formability and spreadability, but also has advantages such as low glycemic index, high skin affinity, and strong antioxidant stability, making it suitable for external application. At the same time, it significantly extends the product's shelf life and improves the user experience and safety.

[0011] In addition, the preparation process has been comprehensively optimized, and key technologies such as low-temperature extraction, vacuum concentration and post-wetting of aromatic medicinal materials are adopted throughout the process. This effectively avoids the loss of heat-sensitive and easily oxidized active ingredients such as volatile oils, saponins and lignans, and greatly improves the retention rate of effective ingredients. High-shear homogenization and temperature-controlled emulsification are introduced in the mixing stage to ensure a high degree of stable fusion of the water and oil phases, resulting in a fine and uniform paste that does not separate or separate during long-term storage.

[0012] Finally, the entire preparation process does not rely on specialized equipment, requiring only conventional Chinese medicine extraction and ointment preparation equipment. The process parameters are clear, the operation is simple, and the reproducibility is good, making it easy to standardize and scale up production, which is conducive to industrial promotion. The finished ointment has a soft texture, pleasant aroma, and high patient compliance, combining efficacy, safety, and practicality. Attached Figure Description

[0013] The above-described aspects and advantages of the present invention will become apparent and readily understood from the following description of the embodiments in conjunction with the accompanying drawings, in which: Figure 1 This is a schematic diagram of the preparation method of the Kaiyu Dingzhi ointment according to an embodiment of the present invention. Detailed Implementation

[0014] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention. Example 1:

[0015] This invention provides a remedy for relieving depression and calming the mind, and its preparation method, comprising the following traditional Chinese herbal medicine components: Bupleurum: 6 parts; Ziziphus jujuba seed: 12 parts; Polygala tenuifolia: 8 parts; Glycyrrhiza uralensis: 4 parts; Cyperus rotundus: 7 parts; Curcuma longa: 6 parts; Acorus tatarinowii: 5 parts; Schisandra chinensis: 6 parts; Salvia miltiorrhiza: 5 parts; Triticum aestivum: 10 parts; Citrus medica: 5 parts; Rosa rugosa: 4 parts; Ganoderma lucidum: 3 parts; Nelumbo nucifera seed heart: 2 parts.

[0016] The matrix components include: maltitol: 90 parts; cocoa butter: 8 parts; jojoba oil: 95 parts; vitamin E: 2 parts.

[0017] Herbal ingredients: Bupleurum: Soothes the liver and relieves depression, raises yang qi. Used for low mood and chest and rib distension caused by liver qi stagnation, it can regulate the level of neurotransmitters in the central nervous system and relieve anxiety. Modern research shows that saikosaponins A and D have significant antidepressant and neuroprotective effects.

[0018] Sour jujube seed: Nourishes the heart and liver, calms the mind and reduces sweating. Used for insomnia due to deficiency and restlessness, palpitations, and night sweats. Its main active ingredients, sour jujube seed saponins A and B, can prolong slow-wave sleep time and improve sleep structure.

[0019] Polygala tenuifolia: Calms the mind and improves intelligence, eliminates phlegm and clears the orifices. Used for forgetfulness, insomnia, and restlessness. Polygala tenuifolia ketone and polygala tenuifolia saponins can promote the expression of brain-derived neurotrophic factor (BDNF) and enhance learning and memory abilities.

[0020] Licorice: Harmonizes the effects of other herbs, invigorates qi and strengthens the middle jiao, relieves spasms and pain. Its glycyrrhizic acid and glycyrrhetinic acid have anti-inflammatory, anti-allergic, and neuroprotective effects, which can reduce the irritation of other herbs to the gastrointestinal tract and improve the overall compatibility and stability of the formula.

[0021] Cyperus rotundus: Soothes the liver and regulates qi, regulates menstruation and relieves pain. It is used for chest tightness, hypochondriac pain and irregular menstruation caused by liver qi stagnation. Cyperene and volatile oil components can regulate the function of the hypothalamus-pituitary-adrenal axis and relieve emotional stress response.

[0022] Turmeric: It promotes qi circulation, removes blood stasis, clears the mind, and relieves depression. It is used for emotional distress, irritability, chest pain, and heart pain. Its curcumin components have antidepressant, antioxidant, and cerebral blood flow improving effects.

[0023] Acorus tatarinowii: It can clear the mind and calm the nerves, resolve dampness and harmonize the stomach. It is used for forgetfulness, insomnia, and mental confusion. The volatile oil of Acorus tatarinowii can penetrate the blood-brain barrier, enhance the brain-boosting effect of Polygala tenuifolia, and inhibit acetylcholinesterase activity.

[0024] Schisandra chinensis: It has astringent and consolidating properties, replenishes qi and promotes the production of body fluids, and calms the mind and soothes the nerves. It is used for palpitations, insomnia, spontaneous sweating, and night sweats. Schisandra chinensis lignans can regulate GABA receptors, producing a sedative effect, while protecting neurons from oxidative damage.

[0025] Danshen (Salvia miltiorrhiza): Promotes blood circulation and removes blood stasis, clears the mind and relieves irritability. It is used for insomnia and restlessness caused by blood stasis. Tanshinone IIA and Tanshinone B can improve microcirculation, reduce cerebral hypoxia, and synergistically enhance the calming effect.

[0026] Floating wheat: It invigorates qi, clears heat, nourishes the heart, and stops sweating. It is used for insomnia, spontaneous sweating, and night sweats caused by yin deficiency and internal heat. It is rich in B vitamins and minerals, gently nourishes the mind, and can replace traditional heavy sedatives such as dragon bone and oyster shell, avoiding the risk of heavy metal residues.

[0027] Buddha's Hand: Soothes the liver and regulates qi, harmonizes the stomach and relieves pain. Used for abdominal distension and belching due to liver and stomach disharmony. Its volatile oil components, such as limonene, can invigorate the spleen and indirectly improve sleep disorders caused by indigestion.

[0028] Rose: Promotes qi circulation, relieves depression, harmonizes blood, and alleviates pain. Used for emotional depression and menstrual irregularities caused by liver qi stagnation. Rich in aromatic volatile oils and polyphenols, it has a mild anti-anxiety effect and imparts a pleasant fragrance to the ointment, improving user compliance.

[0029] Reishi mushroom: It replenishes qi and calms the mind, relieves cough and asthma. It is used for restlessness, insomnia and forgetfulness. Reishi triterpenes and polysaccharides can regulate the immune-neuro-endocrine network and have dual effects of anti-fatigue and nerve repair.

[0030] Lotus seed heart: Clears heart fire and harmonizes the heart and kidneys. Used for irritability, insomnia, and mouth ulcers caused by excessive heart fire. The lotus seed heart alkaloid it contains can inhibit central nervous system excitation and assist jujube seed in enhancing its sedative effect.

[0031] Matrix components: Maltitol: As the main matrix, it is low in calories, does not raise blood sugar, and has anti-caries properties, while also possessing good moisturizing and flavor-correcting effects. Its high viscosity helps the paste to form and is not easily fermented or spoiled, making it significantly superior to traditional honey and suitable for a wider range of people (including diabetic patients and infants).

[0032] Cocoa butter: A natural plant stearin with a melting point of approximately 34–38°C, close to human body temperature. It softens and is quickly absorbed after application, giving the cream a suitable hardness and spreadability. It also forms a micro-occlusive film, reducing moisture evaporation and enhancing the skin barrier function.

[0033] Jojoba oil: Its structure is highly similar to human sebum, and it has strong permeability, effectively carrying fat-soluble active ingredients (such as volatile oils and triterpenoids) into the skin or mucous membranes. Rich in long-chain fatty acids and vitamin E precursors, it possesses excellent antioxidant and anti-inflammatory properties.

[0034] Vitamin E (d-α-tocopherol): A powerful natural antioxidant that prevents the oxidation and rancidity of unsaturated fatty acids in the matrix, extending the shelf life of the ointment; at the same time, it nourishes nerves and skin cells, working synergistically to exert a dual effect of calming the nerves and protecting the skin.

[0035] This application includes the following preparation method for preparing Kaiyu Dingzhi ointment, including steps such as medicinal material pretreatment, low temperature extraction, vacuum concentration, matrix preparation, and mixing and homogenization. Each step is set with precise process parameters to ensure efficient retention of effective ingredients, uniform and stable ointment, and no stratification.

[0036] Step 1: Pre-treatment of Chinese Herbal Medicines: Place Bupleurum, Ziziphus jujuba seed, Polygala tenuifolia, Glycyrrhiza uralensis, Cyperus rotundus, Curcuma longa, Acorus tatarinowii, Schisandra chinensis, Salvia miltiorrhiza, Triticum aestivum, Citrus medica, Ganoderma lucidum, and Nelumbo nucifera heart separately in a clean, dry environment and grind them into coarse powder using a grinder. Pass the powder through a 20-mesh sieve and set aside. Grind rose petals separately at a low temperature below 40°C, pass the powder through a 30-mesh sieve, and store in a sealed, light-proof container to maximize the retention of its volatile aromatic components. Grinding time should be controlled at 2–4 minutes for each herb to ensure uniform particle size and prevent clumping or charring. For hard herbs such as Ganoderma lucidum and Acorus tatarinowii, the grinding time can be appropriately extended to 5 minutes.

[0037] Step 2: Low-Temperature Water Extraction and Vacuum Concentration: Mix all the herbal powders except for the rose petals evenly and place them in a clean stainless steel container. Add 2800 parts of purified water (room temperature 20–25°C) and soak for 40 minutes to allow the herbs to fully wet and swell. Then heat to 90±2°C and maintain this temperature for 2 hours (avoid boiling to reduce the loss of heat-sensitive components). Stir every 20 minutes at 80 rpm to prevent sedimentation and scorching. After extraction, filter while hot through a 200-mesh filter cloth and collect the filtrate. Add another 1800 parts of purified water to the residue and extract at 90°C for 1.5 hours using the same method. Filter and combine the two filtrates. Transfer the combined filtrate to a rotary evaporator and concentrate under reduced pressure at 60°C and a vacuum of -0.08 MPa to approximately 500 parts, with a relative density of 1.20–1.25 (measured at 60°C), yielding a dark brown concentrated extract. The concentration process involves continuous stirring at 100 rpm, and the total time is approximately 2.5 hours.

[0038] Step 3: Post-processing of aromatic herbs: Add rose powder to the above concentrated extract and stir at 120 rpm for 10 minutes in a 55°C water bath to fully dissolve the aromatic components; then cover and seal tightly, and let it steep naturally for 15 minutes (slowly reduce the temperature to 45°C) to lock in the volatile oils and prevent them from escaping. Do not open the lid or stir vigorously throughout the entire process.

[0039] Step 4: Preparation of the ointment base: Place maltitol and jojoba oil in a clean stainless steel pot and heat in a 50°C water bath, stirring at 200 rpm for 15 minutes until completely miscible. Then add cocoa butter, raise the temperature to 55°C, and continue stirring until completely melted and transparent with no particle residue. Finally, cool to 50°C, add vitamin E, and stir at 250 rpm for 10 minutes to form a homogeneous, semi-transparent base liquid. Temperature control accuracy is ±1°C throughout the process to avoid localized overheating and oxidation.

[0040] Step 5: Mixing and Homogenizing: Preheat the concentrated pharmaceutical extract obtained in Step 3 to 50°C, and slowly add it dropwise to the matrix solution in Step 4 while stirring with an electric mixer at 350 rpm. After addition, heat the mixture to 60°C and transfer it to a high-shear emulsifier. Homogenize at 3000 rpm for 30 minutes to ensure complete emulsification of the aqueous and oil phases without oil-water separation. Then transfer it to an atmospheric pressure mixing tank and allow it to cool naturally to 45°C, continuously stirring at 200 rpm during this period to eliminate air bubbles and promote densification of the paste. The final paste should be uniformly brown, smooth, and free of particles or layering.

[0041] Step 6: Filling and Storage: While the ointment is still hot at 45°C, fill it into brown glass bottles that have been autoclaved at 120°C. Immediately fill the bottles with food-grade nitrogen and seal them. Label the finished product with the production date and store it in a cool, dry place (temperature ≤20°C, humidity ≤60%), away from light. The shelf life is 6 months in the unopened state; after opening, it is recommended to refrigerate and use it within 1 month.

[0042] This application includes the following precautions: Thorough mixing: All mixing and homogenization steps must be thorough. A variable frequency electric mixer or high-shear emulsification equipment is recommended. Regularly sample and observe the texture to ensure no layering or oil separation. Hygiene requirements: All equipment must be sterilized by autoclaving at 120°C for 30 minutes before use. Operators must wear sterile clothing, masks, and gloves, and operate in an environment with a cleanliness level of at least D. Quality inspection: The finished ointment should be a brown to dark brown translucent paste with a light rose and herbal aroma, free from burnt, rancid, or foreign matter odors. The pH value should be controlled between 5.0 and 6.5. If slight layering occurs, it can be restored to homogeneity by re-stirring at 200 rpm for 20 minutes in a 60°C water bath. Individual differences: Before first use, it is recommended to test on a small area on the inside of the wrist or behind the ear. Observe for 24 hours; if no redness, swelling, or itching occurs, continued use is permitted. Pregnant women, breastfeeding women, children, and those with severe liver or kidney dysfunction should use under the guidance of a physician. Storage conditions: Keep away from direct sunlight and heat sources. If the paste changes color, develops an odor, becomes moldy, or shows excessive water separation, discontinue use immediately and discard the product. Example 2:

[0043] This invention provides a remedy for relieving depression and calming the mind, and its preparation method, comprising the following traditional Chinese herbal ingredients: Bupleurum chinense: 5 parts; Ziziphus jujuba var. spinosa: 10 parts; Polygala tenuifolia: 5 parts; Glycyrrhiza uralensis: 3 parts; Cyperus rotundus: 5 parts; Curcuma longa: 5 parts; Acorus tatarinowii: 3 parts; Schisandra chinensis: 5 parts; Salvia miltiorrhiza: 1 part; Triticum aestivum: 5 parts; Citrus medica: 4 parts; Rosa rugosa: 3 parts; Ganoderma lucidum: 1 part; Nelumbo nucifera: 1 part. It also comprises the following matrix ingredients: Maltitol: 50 parts; Cocoa butter: 5 parts; Jojoba oil: 50 parts; Vitamin E: 1 part.

[0044] The preparation method for the Kaiyu Dingzhi ointment includes the following steps: herbal pretreatment, low-temperature extraction, vacuum concentration, matrix preparation, and mixing and homogenization. Each step has precise process parameters to ensure efficient retention of active ingredients, uniform and stable ointment, and no stratification.

[0045] Step 1: Pre-treatment of Chinese Herbal Medicines: Place Bupleurum, Ziziphus jujuba seed, Polygala tenuifolia, Glycyrrhiza uralensis, Cyperus rotundus, Curcuma longa, Acorus tatarinowii, Schisandra chinensis, Salvia miltiorrhiza, Triticum aestivum, Citrus medica, Ganoderma lucidum, and Nelumbo nucifera heart separately in a clean, dry environment and grind them into coarse powder using a grinder. Pass the powder through a 20-mesh sieve and set aside. Grind rose petals separately at a low temperature below 40°C, pass the powder through a 30-mesh sieve, and store in a sealed, light-proof container to maximize the retention of its volatile aromatic components. Grinding time should be controlled at 2–4 minutes for each herb to ensure uniform particle size and prevent clumping or charring. For hard herbs such as Ganoderma lucidum and Acorus tatarinowii, the grinding time can be appropriately extended to 5 minutes.

[0046] Step 2: Low-Temperature Water Extraction and Vacuum Concentration: Mix all the herbal powders except for the rose petals evenly and place them in a clean stainless steel container. Add 2800 parts of purified water (room temperature 20–25°C) and soak for 40 minutes to allow the herbs to fully wet and swell. Then heat to 90±2°C and maintain this temperature for 2 hours (avoid boiling to reduce the loss of heat-sensitive components). Stir every 20 minutes at 80 rpm to prevent sedimentation and scorching. After extraction, filter while hot through a 200-mesh filter cloth and collect the filtrate. Add another 1800 parts of purified water to the residue and extract at 90°C for 1.5 hours using the same method. Filter and combine the two filtrates. Transfer the combined filtrate to a rotary evaporator and concentrate under reduced pressure at 60°C and a vacuum of -0.08 MPa to approximately 500 parts, with a relative density of 1.20–1.25 (measured at 60°C), yielding a dark brown concentrated extract. The concentration process involves continuous stirring at 100 rpm, and the total time is approximately 2.5 hours.

[0047] Step 3: Post-processing of aromatic herbs: Add rose powder to the above concentrated extract and stir at 120 rpm for 10 minutes in a 55°C water bath to fully dissolve the aromatic components; then cover and seal tightly, and let it steep naturally for 15 minutes (slowly reduce the temperature to 45°C) to lock in the volatile oils and prevent them from escaping. Do not open the lid or stir vigorously throughout the entire process.

[0048] Step 4: Preparation of the ointment base: Place maltitol and jojoba oil in a clean stainless steel pot and heat in a 50°C water bath, stirring at 200 rpm for 15 minutes until completely miscible. Then add cocoa butter, raise the temperature to 55°C, and continue stirring until completely melted and transparent with no particle residue. Finally, cool to 50°C, add vitamin E, and stir at 250 rpm for 10 minutes to form a homogeneous, semi-transparent base liquid. Temperature control accuracy is ±1°C throughout the process to avoid localized overheating and oxidation.

[0049] Step 5: Mixing and Homogenizing: Preheat the concentrated pharmaceutical extract obtained in Step 3 to 50°C, and slowly add it dropwise to the matrix solution in Step 4 while stirring with an electric mixer at 350 rpm. After addition, heat the mixture to 60°C and transfer it to a high-shear emulsifier. Homogenize at 3000 rpm for 30 minutes to ensure complete emulsification of the aqueous and oil phases without oil-water separation. Then transfer it to an atmospheric pressure mixing tank and allow it to cool naturally to 45°C, continuously stirring at 200 rpm during this period to eliminate air bubbles and promote densification of the paste. The final paste should be uniformly brown, smooth, and free of particles or layering.

[0050] Step 6: Filling and Storage: While the ointment is still hot at 45°C, fill it into brown glass bottles that have been autoclaved at 120°C. Immediately fill the bottles with food-grade nitrogen and seal them. Label the finished product with the production date and store it in a cool, dry place (temperature ≤20°C, humidity ≤60%), away from light. Example 3:

[0051] This invention provides a remedy for relieving depression and calming the mind, and its preparation method, comprising the following traditional Chinese herbal ingredients: Bupleurum chinense: 7 parts; Ziziphus jujuba var. spinosa: 20 parts; Polygala tenuifolia: 10 parts; Glycyrrhiza uralensis: 5 parts; Cyperus rotundus: 10 parts; Curcuma longa: 7 parts; Acorus tatarinowii: 10 parts; Schisandra chinensis: 7 parts; Salvia miltiorrhiza: 6 parts; Triticum aestivum: 15 parts; Citrus medica: 6 parts; Rosa rugosa: 7 parts; Ganoderma lucidum: 5 parts; Nelumbo nucifera: 3 parts. It also comprises the following matrix ingredients: Maltitol: 120 parts; Cocoa butter: 10 parts; Jojoba oil: 150 parts; Vitamin E: 3 parts.

[0052] The preparation method for the Kaiyu Dingzhi ointment includes the following steps: herbal pretreatment, low-temperature extraction, vacuum concentration, matrix preparation, and mixing and homogenization. Each step has precise process parameters to ensure efficient retention of active ingredients, uniform and stable ointment, and no stratification.

[0053] Step 1: Pre-treatment of Chinese Herbal Medicines: Place Bupleurum, Ziziphus jujuba seed, Polygala tenuifolia, Glycyrrhiza uralensis, Cyperus rotundus, Curcuma longa, Acorus tatarinowii, Schisandra chinensis, Salvia miltiorrhiza, Triticum aestivum, Citrus medica, Ganoderma lucidum, and Nelumbo nucifera heart separately in a clean, dry environment and grind them into coarse powder using a grinder. Pass the powder through a 20-mesh sieve and set aside. Grind rose petals separately at a low temperature below 40°C, pass the powder through a 30-mesh sieve, and store in a sealed, light-proof container to maximize the retention of its volatile aromatic components. Grinding time should be controlled at 2–4 minutes for each herb to ensure uniform particle size and prevent clumping or charring. For hard herbs such as Ganoderma lucidum and Acorus tatarinowii, the grinding time can be appropriately extended to 5 minutes.

[0054] Step 2: Low-Temperature Water Extraction and Vacuum Concentration: Mix all the herbal powders except for the rose petals evenly and place them in a clean stainless steel container. Add 2800 parts of purified water (room temperature 20–25°C) and soak for 40 minutes to allow the herbs to fully wet and swell. Then heat to 90±2°C and maintain this temperature for 2 hours (avoid boiling to reduce the loss of heat-sensitive components). Stir every 20 minutes at 80 rpm to prevent sedimentation and scorching. After extraction, filter while hot through a 200-mesh filter cloth and collect the filtrate. Add another 1800 parts of purified water to the residue and extract at 90°C for 1.5 hours using the same method. Filter and combine the two filtrates. Transfer the combined filtrate to a rotary evaporator and concentrate under reduced pressure at 60°C and a vacuum of -0.08 MPa to approximately 500 parts, with a relative density of 1.20–1.25 (measured at 60°C), yielding a dark brown concentrated extract. The concentration process involves continuous stirring at 100 rpm, and the total time is approximately 2.5 hours.

[0055] Step 3: Post-processing of aromatic herbs: Add rose powder to the above concentrated extract and stir at 120 rpm for 10 minutes in a 55°C water bath to fully dissolve the aromatic components; then cover and seal tightly, and let it steep naturally for 15 minutes (slowly reduce the temperature to 45°C) to lock in the volatile oils and prevent them from escaping. Do not open the lid or stir vigorously throughout the entire process.

[0056] Step 4: Preparation of the ointment base: Place maltitol and jojoba oil in a clean stainless steel pot and heat in a 50°C water bath, stirring at 200 rpm for 15 minutes until completely miscible. Then add cocoa butter, raise the temperature to 55°C, and continue stirring until completely melted and transparent with no particle residue. Finally, cool to 50°C, add vitamin E, and stir at 250 rpm for 10 minutes to form a homogeneous, semi-transparent base liquid. Temperature control accuracy is ±1°C throughout the process to avoid localized overheating and oxidation.

[0057] Step 5: Mixing and Homogenizing: Preheat the concentrated pharmaceutical extract obtained in Step 3 to 50°C, and slowly add it dropwise to the matrix solution in Step 4 while stirring with an electric mixer at 350 rpm. After addition, heat the mixture to 60°C and transfer it to a high-shear emulsifier. Homogenize at 3000 rpm for 30 minutes to ensure complete emulsification of the aqueous and oil phases without oil-water separation. Then transfer it to an atmospheric pressure mixing tank and allow it to cool naturally to 45°C, continuously stirring at 200 rpm during this period to eliminate air bubbles and promote densification of the paste. The final paste should be uniformly brown, smooth, and free of particles or layering.

[0058] Step 6: Filling and storage: Fill the ointment into brown glass bottles that have been autoclaved at 120°C while it is still hot at 45°C, immediately fill with food-grade nitrogen and then seal.

[0059] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A remedy for relieving depression and calming the mind, and its preparation method, characterized in that: The formula includes the following Chinese herbal ingredients: Bupleurum: 5-7 parts; Ziziphus jujuba seed: 10-20 parts; Polygala tenuifolia: 5-10 parts; Glycyrrhiza uralensis: 3-5 parts; Cyperus rotundus: 5-10 parts; Curcuma longa: 5-7 parts; Acorus tatarinowii: 3-10 parts; Schisandra chinensis: 5-7 parts; Salvia miltiorrhiza: 1-6 parts; Triticum aestivum: 5-15 parts; Buddha's Hand: 4-6 portions; Roses: 3-7 portions; Reishi mushroom: 1-5 portions; Lotus seed hearts: 1-3 portions.

2. The antidepressant and calming ointment and its preparation method according to claim 1, characterized in that: It includes the following matrix components: maltitol: 50-120 parts; cocoa butter: 5-10 parts; jojoba oil: 50-150 parts; vitamin E: 1-3 parts.

3. The antidepressant and calming ointment and its preparation method according to claim 1, characterized in that: The preparation methods include the following: Step 1: Pre-treatment of Chinese herbal medicines: Grind the Chinese herbal medicines into powder and sieve them; Step 2: Low-temperature water extraction and vacuum concentration: Mix all the medicinal powders except for the rose petals evenly, put them into a stainless steel container, add purified water to soak, and concentrate under vacuum. Step 3: Post-processing of aromatic herbs: Add rose powder to the concentrated extract produced in Step 2, heat and stir to fully dissolve the aromatic components; Step 4: Prepare the ointment base: Place maltitol and jojoba oil in a pot and heat in a water bath to dissolve them; then add cocoa butter and stir to combine. Step 5: Mixing and Homogenizing: Preheat the concentrated extract produced in Step 3 and add it dropwise to the matrix liquid produced in Step 4 to mix and prepare the paste; Step 6: Filling and storage: Fill the ointment into sterile brown glass bottles.

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