Preparation method of phthalimide compound

By combining ethanol solvent and p-toluenesulfonic acid catalyst, along with purification treatment using sodium bicarbonate aqueous solution and deionized water, the high energy consumption and corrosiveness problems in the preparation of phthalimide compounds were solved, achieving a low-cost and safe preparation process.

CN121673215APending Publication Date: 2026-03-17ANHUI DACAI TECHNOLOGY CO LTD
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Patent Information

Application Number
CN202511677796.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-11-17
Publication Date
2026-03-17

AI Technical Summary

Technical Problem

Existing methods for preparing phthalimide compounds suffer from high energy consumption, carbonization of raw materials, and darkening of product color. Furthermore, the recovery of high-boiling-point solvents is cumbersome and does not align with the trend of green chemical development.

Method used

Ethanol was used as a solvent, and p-toluenesulfonic acid and phosphorus pentoxide were used as catalysts to generate phthalimide compounds through a stirring reaction. The products were then purified using sodium bicarbonate aqueous solution and deionized water, and obtained after vacuum drying.

Benefits of technology

This process achieves low-energy consumption and safety, reduces costs, minimizes organic acid corrosivity, and improves catalyst recoverability and product purity.

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Abstract

The invention relates to the technical field of chemical preparation, and discloses a preparation method of a phthalimide compound, which comprises the following steps: S1, raw material mixing: sequentially adding phthalic anhydride, a primary amine compound, p-toluenesulfonic acid and phosphorus pentoxide into a reaction container with a stirring device and a temperature control module, and stirring for 1-2 hours; adding ethanol as a solvent, and carrying out a stirring reaction; s2, curing: cooling the reaction liquid to 20-25 DEG C, slowly adding deionized water into the reaction liquid while stirring, standing, and separating out a solid product; a traditional dehydrating agent is changed into a low-cost green dehydrating agent combination, so that the cost loss is reduced, the stimulation effect is reduced, the catalytic activity is equivalent to that of p-toluenesulfonic acid by adding a new sulfonic group functional polymer, but the problems of volatility of liquid acid and equipment corrosion are avoided, a low-toxicity and low-cost solvent of ethanol is added, the toxicity is reduced, and the environment-friendly dehydrating agent is prepared. The preparation is safer, the cost is lower, and the applicability is wider.
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