Application of a lignin monomer transporter
A novel lignin transporter, LAT, was screened using the deep learning model EACR, which solved the problem of low lignin utilization efficiency in microorganisms, realized the efficient transport and simultaneous biosynthesis of aromatic compounds, and improved the economics and industrial application prospects of lignin utilization.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- TIANJIN INST OF IND BIOTECH CHINESE ACADEMY OF SCI
- Filing Date
- 2026-02-11
- Publication Date
- 2026-06-30
AI Technical Summary
In existing technologies, the transmembrane transport system for lignin-derived aromatic compounds by microorganisms is inefficient. Traditional methods rely on sequence homology prediction, which makes it difficult to discover novel transport proteins, resulting in low lignin utilization efficiency.
By using the deep learning-driven protein-ligand affinity prediction model EACR, a novel lignin-derived aromatic transporter (LAT) was screened and heterologously expressed in Pichia pastoris to construct an engineered strain that efficiently utilizes lignin, thereby achieving the synchronous biosynthesis of aromatic compounds.
This method enables microorganisms to directly utilize lignin-derived aromatic compounds as a carbon source and simultaneously produce high-value products, overcoming carbon flow conflicts in traditional pathways and improving the economic feasibility and industrial application potential of lignin utilization.
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Figure CN121674449B_ABST