Traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction and application thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction and application thereof. The traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction is prepared from the following raw materials: fried semen raphani, fructus aurantii stir-fried with bran, fried fructus aurantii immaturus, raw liquorice, radix paeoniae alba, rheum officinale, rhizoma zingiberis, codonopsis pilosula, bupleurum chinense, ginger-processed cortex magnoliae officinalis and lignum dalbergiae odoriferae. The prescription is based on the core theories of'six internal organs are used for dredging ', 'qi movement is caused by rising and falling' and'healthy energy is strengthened and attacks evil 'in the traditional Chinese medicine, and the prescription aims to dredge triple jiao, smooth qi movement, dredge the internal organs, purge turbidity and strengthen the healthy energy. The whole formula takes'dredging and descending 'as a main component, 'ascending and dispersing' as an auxiliary component and'tonifying 'as an assistant component, so that a precise compatibility system with simultaneous ascending and descending and simultaneous purgation and tonification is formed. The traditional Chinese medicine enema composition is remarkable in clinical curative effect, low in recurrence rate and free of adverse reaction, the preparation process is simple and easy to implement and easy to popularize and apply, and the traditional Chinese medicine enema composition has good social benefits and economic benefits.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction and its application. Background Technology

[0002] After abdominal surgery, gynecological surgery, or orthopedic surgery, patients often experience gastrointestinal dysfunction due to factors such as anesthesia, surgical trauma, and inflammatory reactions. Clinical manifestations include abdominal distension, abdominal pain, cessation of defecation and flatulence, nausea, and vomiting. In severe cases, it can develop into postoperative intestinal obstruction, prolonging hospitalization, increasing patient suffering, and medical expenses.

[0003] Currently, Western medicine treatments for postoperative gastrointestinal dysfunction mainly include gastrointestinal decompression, prokinetic drugs, and nutritional support. However, these methods have limitations in efficacy, side effects (such as drug-induced arrhythmias), and poor patient tolerance. Traditional Chinese medicine has unique advantages in regulating gastrointestinal function, but existing oral preparations are difficult to absorb for patients with postoperative gastrointestinal motility stagnation and may further burden the gastrointestinal tract.

[0004] These existing technologies all have their own limitations and defects, as follows: (a) Deficiencies of conventional Western medicine treatment 1. Gastrointestinal decompression: passive waiting, unable to actively restore function. 1) Treating the symptoms but not the root cause: Gastrointestinal decompression can only temporarily relieve abdominal distension by suctioning out accumulated gas and fluid in the gastrointestinal tract through negative pressure. It is a passive physical decompression method. It cannot actively promote the recovery of gastrointestinal motility, and symptoms are prone to recurrence once the tube is removed.

[0005] 2) Patient discomfort and complications: Nasal nasogastric tube placement can cause patients significant throat discomfort, nausea, and pain, affecting rest and sleep, and increasing the risk of complications such as respiratory tract infection, nasal mucosal damage, and otitis.

[0006] 3) Nutritional and electrolyte disorders: Long-term gastrointestinal decompression can lead to the loss of a large amount of digestive fluids, causing water, electrolyte and acid-base imbalances, while also hindering the early implementation of enteral nutrition, which is not conducive to the patient's overall recovery.

[0007] 2. Gastrointestinal motility drugs: limited efficacy and accompanied by side effects. 1) Uncertain efficacy: In a state of complete gastrointestinal paralysis, systemic application of prokinetic drugs (such as neostigmine, mosapride, etc.) is often ineffective because the drugs are difficult to reach an effective concentration at the lesion site through blood circulation.

[0008] 2) Cardiovascular side effects: Many prokinetic drugs have potentially serious side effects. For example, neostigmine may cause bradycardia, arrhythmia, bronchospasm, etc.; domperidone (Motilium) has been restricted in some countries due to its risk of causing QT interval prolongation and serious arrhythmias.

[0009] 3) Many contraindications: These drugs are contraindicated or require caution in patients with underlying diseases such as asthma, bradycardia, and intestinal obstruction, which limits their clinical application.

[0010] 3. Nutritional support and symptomatic treatment: cannot solve the underlying problem. 1) Passive support: Although total parenteral nutrition (TPN) can provide energy, it cannot replace the stimulating effect of enteral nutrition on the intestinal mucosal barrier and neuroendocrine system. Long-term TPN can lead to intestinal flora translocation, liver function damage, and increased risk of infection.

[0011] 2) Treating symptoms but not the underlying cause: Using painkillers (such as opioids) may further inhibit intestinal peristalsis, creating a vicious cycle.

[0012] In summary, most existing Western medicine treatments are "passive support" and "symptomatic treatment," lacking ideal means to actively, safely, and effectively restore the autonomous peristaltic function of the gastrointestinal tract, and are often accompanied by significant side effects and patient discomfort.

[0013] (II) Deficiencies in existing traditional Chinese medicine treatments 1. Limitations of oral administration 1) Absorption disorder: The core manifestation of postoperative gastrointestinal dysfunction is the stagnation or weakening of gastrointestinal motility. At this time, oral Chinese medicine decoctions or prepared medicines will remain in the stomach and are difficult to be effectively absorbed and transported to the intestinal site of action, resulting in extremely low bioavailability and greatly reduced efficacy.

[0014] 2) Increased burden: Oral administration of large amounts of liquid decoction may further aggravate the patient's abdominal distension, nausea and other discomforts, which is contrary to the purpose of treatment.

[0015] 2. The singularity of traditional Chinese medicine dosage forms and administration methods 1) Lack of targeted dosage forms: Most Chinese patent medicines on the market (such as pills, capsules, tablets) have fixed formulas, making it difficult to make individualized additions or subtractions according to the specific syndrome of patients, resulting in poor flexibility.

[0016] 2) Insufficient innovation in drug administration methods: Traditional Chinese medicine treatment for gastrointestinal dysfunction is mostly limited to oral administration, and there is insufficient research and application of innovative drug administration methods that bypass absorption barriers and deliver drugs directly to the affected area.

[0017] Chinese patent CN201510487565.1 discloses a traditional Chinese medicine composition and preparation method for promoting the recovery of gastrointestinal function after surgery. The composition contains 200 parts by weight of Amomum tsao-ko, 100 parts by weight of Amomum villosum, 150 parts by weight of Evodia rutaecarpa, and 100 parts by weight of Alpinia oxyphylla. The traditional Chinese medicine composition is made into a hot compress bag, but the therapeutic effect is not good.

[0018] Therefore, there is an urgent clinical need for a treatment method that can bypass oral absorption barriers, act directly on the lesion site, and is fast-acting, safe, and effective. Summary of the Invention

[0019] In order to overcome the shortcomings and deficiencies of the prior art, the present invention provides a traditional Chinese medicine enema composition, its preparation method and application, which has a good effect on treating postoperative gastrointestinal dysfunction, has no toxic side effects, and can effectively solve the problems existing in the prior art.

[0020] The primary objective of this invention is to overcome the shortcomings of the prior art and provide a traditional Chinese medicine composition that is effective, fast-acting, and safe for treating postoperative gastrointestinal dysfunction.

[0021] Another object of the present invention is to provide a method for preparing the above-mentioned traditional Chinese medicine composition.

[0022] Another object of the present invention is to provide the use of the above-mentioned traditional Chinese medicine composition in the preparation of a medicament for treating postoperative gastrointestinal dysfunction by enema.

[0023] To achieve the above objectives, the present invention adopts the following technical solution: a traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction. Addressing the shortcomings of current Western medicine treatments, such as poor efficacy and numerous side effects, and the limited routes of administration for traditional Chinese medicine, this invention provides an enema traditional Chinese medicine combination, specifically made from the following raw materials in parts by weight: stir-fried radish seeds, stir-fried bitter orange peel, stir-fried bitter orange fruit, raw licorice root, white peony root, rhubarb, dried ginger, codonopsis root, bupleurum root, ginger-processed magnolia bark, and sandalwood.

[0024] Furthermore, the traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction comprises the following ingredients: 10-20g of stir-fried radish seeds, 10-15g of stir-fried bitter orange peel, 15-20g of stir-fried bitter orange, 20-30g of raw licorice root, 5-10g of stir-fried white peony root, 10-15g of raw rhubarb, 10-20g of dried ginger, 10-15g of codonopsis root, 10-12g of bupleurum root, 20-30g of ginger-processed magnolia bark, and 1-3g of sandalwood.

[0025] Furthermore, the traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction comprises the following ingredients by weight: 20 parts of stir-fried radish seeds, 15 parts of stir-fried bitter orange peel, 20 parts of stir-fried bitter orange fruit, 30 parts of raw licorice root, 10 parts of white peony root, 15 parts of rhubarb, 20 parts of dried ginger, 15 parts of codonopsis root, 12 parts of bupleurum root, 30 parts of ginger-processed magnolia bark, and 3 parts of sandalwood.

[0026] Furthermore, the traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction comprises the following ingredients by weight: 10 parts of stir-fried radish seeds, 10 parts of stir-fried bitter orange peel, 15 parts of stir-fried bitter orange fruit, 20 parts of raw licorice root, 5 parts of white peony root, 10 parts of rhubarb, 10 parts of dried ginger, 10 parts of codonopsis root, 10 parts of bupleurum root, 20 parts of ginger-processed magnolia bark, and 1 part of sandalwood.

[0027] Furthermore, the traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction comprises the following ingredients by weight: 15 parts of stir-fried radish seeds, 15 parts of stir-fried bitter orange peel, 20 parts of stir-fried bitter orange, 25 parts of raw licorice root, 5 parts of white peony root, 15 parts of rhubarb, 10 parts of dried ginger, 10 parts of codonopsis root, 10 parts of bupleurum root, 25 parts of ginger-processed magnolia bark, and 3 parts of sandalwood.

[0028] One aspect of this invention relates to compositions, wherein the "composition" is sufficient to achieve the effects described in this application, and the "composition" includes, but is not limited to, the simultaneous or sequential use of the components. "Simultaneous use" includes using them together in the same formulation or separately in different formulations. "Sequential use" includes using them sequentially in different formulations, with no restriction on the order of sequential use.

[0029] The preparation method of the traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction of the present invention is as follows: S1. Soak all medicinal materials in 5-10 times the amount of water for 30-60 minutes; S2. After bringing to a boil over high heat, simmer over low heat for 20-40 minutes, then filter to obtain the first filtrate and dregs. S3. Add 3-8 times the amount of water to the dregs, bring to a boil over high heat, then simmer over low heat for 15-30 minutes, filter, and obtain the second filtrate. S4. Combine the two filtrates and concentrate them to a concentration of 0.5-2.0 g / mL of raw medicinal material to obtain the enema decoction.

[0030] Furthermore, the preparation method of the present invention is as follows: S1. Soak all medicinal herbs in 8 times the amount of water for 40 minutes; S2. After bringing to a boil over high heat, simmer over low heat for 30 minutes, then filter to obtain the first filtrate and dregs. S3. Add 6 times the amount of water to the dregs, bring to a boil over high heat, then simmer over low heat for 20 minutes, filter, and obtain the second filtrate. S4. Combine the two filtrates and concentrate them to a concentration of 1.0 g / mL of raw medicinal material to obtain the enema decoction.

[0031] The present invention provides the use of the traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction in the preparation of drugs for the prevention or treatment of postoperative gastrointestinal dysfunction.

[0032] The formula analysis of the traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction of the present invention is as follows: I. Overall syndrome differentiation and legislation The formula of the present invention is based on the core theories of traditional Chinese medicine, namely "the six fu-organs function smoothly when unobstructed", "the ascending and descending of qi activities depend on each other", and "strengthening the healthy qi to eliminate pathogenic factors". Its legislation aims to dredge the triple energizer, smooth the qi activity, promote defecation and eliminate turbidity, and strengthen the healthy qi by the way. It mainly targets a series of complex syndromes with the core pathogenesis of qi stagnation, intestinal qi obstruction, and internal retention of turbid pathogens, which may be accompanied by deficiency of healthy qi. The whole formula focuses on "descending and purging", supplemented by "ascending and dispersing", and assisted by "tonifying", forming a precise compatibility system that coordinates the ascending and descending and combines attacking and tonifying.

[0033] II. Analysis of the compatibility mechanism of monarch, minister, assistant, and courier drugs (I) Monarch drugs - targeting the main disease and main syndrome, playing a leading role Fructus Aurantii Immaturus stir-fried (15 - 20 g), Fructus Aurantii stir-fried with bran (10 - 15 g), Magnolia Officinalis with ginger (20 - 30 g), Semen Raphani stir-fried (10 - 20 g) Mechanism elaboration: These four drugs together serve as the monarch drugs, jointly undertaking the core mission of promoting qi movement, breaking knots, eliminating accumulation, and relieving fullness.

[0034] Fructus Aurantii Immaturus stir-fried and Fructus Aurantii stir-fried with bran are used in combination. Fructus Aurantii Immaturus breaks qi and eliminates accumulation, with a strong downward-acting force, mainly entering the spleen and stomach, and is good at breaking qi stagnation in the gastrointestinal tract; Fructus Aurantii stir-fried with bran regulates qi and relieves fullness, with a slow-acting upward-acting force, mainly entering the chest diaphragm, and is good at relieving fullness in the chest and promoting qi movement in the diaphragm. One goes up and the other goes down, one is strong and the other is slow, jointly regulating the ascending and descending of qi in the middle and upper energizers, and is the key to dredging the key link in the middle energizer.

[0035] Magnolia Officinalis with ginger is bitter, pungent, warm, dry, reduces qi and relieves fullness, dries dampness and eliminates phlegm, with a descending nature, and can strongly promote the downward movement of intestinal turbid qi, synergizing with Fructus Aurantii Immaturus to enhance the power of purging the intestinal tract.

[0036] Semen Raphani stir-fried promotes digestion and eliminates accumulation, reduces qi and dissipates phlegm, and is especially good at eliminating the accumulation of flour foods. Its "powerful" nature can significantly enhance the efficacy of promoting defecation and guiding stagnation of the whole formula.

[0037] This combination of monarch drugs has a strong medicinal power, focusing on the middle and lower energizers, and using the means of promoting qi movement, breaking qi, and reducing qi to strongly solve the core contradiction of "qi stagnation" and "intestinal stasis".

[0038] (II) Minister drugs - assisting the monarch drugs to strengthen the therapeutic effect Bupleurum chinense (10 - 12 g), Rheum palmatum (10 - 15 g) Mechanism elaboration: Bupleurum chinense (Northern Bupleurum): This herb is a key medicine for soothing the liver, relieving depression, and regulating the flow of Qi. Its nature is light, clear, and ascending, effectively clearing liver Qi and relieving stagnation. When combined with the principal herbs, such as Citrus aurantium (Zhi Shi) and Magnolia officinalis (Houpu), which are primarily descending, it forms the famous "Bupleurum-Citrus aurantium" ascending-descending pair. This combination of ascending and descending herbs soothes the liver and spleen, facilitating the smooth flow of Qi throughout the body, preventing stagnation, and assisting the principal herbs in addressing the root cause of Qi stagnation at a deeper level.

[0039] Raw rhubarb: Revered as the "general's medicine," it is bitter, cold, and descending, with a strong and penetrating effect, capable of purging and eliminating stagnation, clearing heat and purging fire. In this formula, it serves as the assistant herb, providing a clear outlet for the "descending" power of the principal herb—facilitating bowel movements, allowing stagnant qi and accumulated pathogens to be released from below. Its purgative effect is a crucial step in realizing the principle of "using unblocking as the primary function."

[0040] (iii) Adjuvant drugs - assist the principal and assistant drugs, treat secondary symptoms, or restrain their potency. Dried ginger (10-20g), Codonopsis pilosula (10-15g), stir-fried white peony root (5-10g), Dalbergia odorifera (1-3g) Mechanism explanation: The adjuvant components have clear functions and take into account multiple aspects.

[0041] Dried ginger: warms the middle and dispels cold. This formula uses a large amount of qi-regulating and purgative herbs, many of which are quite potent. Rhubarb is also cold in nature and can easily damage the yang of the middle jiao. The warmth of dried ginger can counteract the coldness of rhubarb, prevent the coldness from harming the stomach, and protect the yang qi of the middle jiao, reflecting the wisdom of "removing the nature and retaining the function" in the formulation.

[0042] Codonopsis pilosula: Tonifies Qi and strengthens the spleen. Medicines that promote Qi circulation and dispel stagnation, as well as those that purge, easily deplete the body's vital energy. Codonopsis pilosula here supports the vital energy, preventing excessive attack, ensuring that the entire formula attacks the pathogenic factors without harming the body's vital energy, achieving a balance of attack and tonification, especially suitable for syndromes with mixed deficiency and excess.

[0043] Stir-fried white peony root: Nourishes blood and softens the liver, relieves spasms and pain. Its sour and astringent properties can counteract the potential depletion of yin and blood caused by pungent and drying herbs such as immature bitter orange and magnolia bark; at the same time, it can be combined with licorice root (in the context of Peony and Licorice Decoction) to relieve abdominal cramps and pain caused by qi stagnation.

[0044] Dalbergia odorifera: Promotes blood circulation, regulates Qi, and relieves pain. Prolonged Qi stagnation inevitably leads to blood stasis. Dalbergia odorifera is pungent, warm, and aromatic, readily entering the blood and dispersing stasis to relieve pain. When used in small amounts, it aims to clear minor stagnations of Qi and blood in the meridians, providing a good adjunctive treatment for pain caused by Qi stagnation and blood stasis.

[0045] (iv) Guiding medicine - harmonizing various medicines and guiding them through the meridians. Raw licorice root (20-30g) Mechanism explanation: Harmonizing the other herbs: Raw licorice root is sweet and neutral in nature. It is used in a large quantity in this formula. Its primary function is to harmonize the different properties of the herbs, such as cold, heat, warmth, coolness, ascending and descending, dispersing and astringing, so that they can work synergistically without antagonism. It also moderates the harshness of herbs such as immature bitter orange and rhubarb in the formula, making the overall effect of the formula more stable and lasting.

[0046] Clearing heat and detoxifying: Raw licorice has the function of clearing heat and detoxifying, and can assist rhubarb in clearing the stagnant heat that may be caused by obstruction of the internal organs.

[0047] Relieves pain and relieves spasms: When combined with white peony root, it enhances the effect of relieving pain and relieving spasms.

[0048] The herbal enema composition of the present invention has the following improvements: I. Essential Traditional Chinese Medicine (Core Herbal Composition) From the perspective of the theory of monarch, minister, assistant, and guide (or similar principles) and the overall efficacy of the prescription, the following drugs constitute the framework of this prescription and are indispensable. We can divide them into two levels: "absolute core" and "important support".

[0049] Tier 1: Absolute Core (Prime Minister and Core Assistant Ministers) The absence of these herbs will directly lead to a fundamental change in the legal basis and core efficacy of the prescription.

[0050] 1. Fried immature bitter orange and bran-fried immature bitter orange peel: These are the "pivots" in this formula for regulating Qi. One breaks down and the other widens, one descends and the other ascends, working synergistically to unblock the Qi of the middle and third Jiao. Removing either ingredient would disrupt this three-dimensional Qi-regulating structure.

[0051] 2. Magnolia officinalis: A key herb for relieving abdominal distension and promoting the downward movement of turbid qi in the intestines. Without it, the effectiveness of promoting the downward movement of qi in the intestines will be greatly reduced.

[0052] 3. Raw rhubarb: The key to providing an "outlet" for pathogenic factors. It is the executor of the principle of "clearing the bowels and purging turbidity," allowing stagnant qi and accumulated pathogenic factors to be expelled through the stool. Without rhubarb, the "clearing" method is ineffective.

[0053] In summary, these four herbs (actually three groups of four herbs) together constitute the core power of promoting qi circulation, breaking up stagnation, clearing the bowels, and guiding out obstruction, which is the foundation of the formula's existence.

[0054] Level Two: Key Supporting Agents (Crucial Herbs and Adjuvants) Although these medicines are not the absolute core, their presence greatly affects the breadth, depth, and safety of the prescription's efficacy.

[0055] 1. Bupleurum chinense (Bei Chai Hu): It provides the dimension of "soothing the liver and relieving depression," addressing one of the "sources" of qi stagnation. Without Bupleurum chinense, the formula lacks an important qi regulation axis (liver-spleen axis), weakening its effectiveness for symptoms caused by emotional factors.

[0056] 2. Fried radish seeds: A powerful remedy for indigestion and phlegm, significantly enhancing the guiding effect of the principal herb. Its effect is particularly crucial in cases of food stagnation and phlegm obstruction.

[0057] 3. Dried ginger and Codonopsis pilosula: This combination embodies the concept of "integrated attack and defense" in the prescription.

[0058] Dried ginger: counteracts the cold nature of rhubarb, protects the spleen and stomach's yang energy, and prevents excessive purging.

[0059] Codonopsis pilosula: It supports the body's vital energy and prevents qi-regulating and purgative drugs from depleting the body's vital energy.

[0060] Removing these two ingredients turns the formula into a purely aggressive and domineering remedy, narrowing its applicability to a wider range of people and making it unsuitable for long-term use.

[0061] 4. Raw licorice root: As the guiding herb, it is used in the largest quantity, and its role in "harmonizing the other herbs" is crucial. It can moderate the harshness of the herbs, making the overall effect of the formula more stable and lasting. Without licorice root, the synergy of the herbs in the formula will decrease, and discomfort may occur due to the harshness of the herbs.

[0062] II. Special processing required for Chinese medicinal materials In addition to the processes mentioned above, the processing and handling of the medicinal materials themselves are also crucial, as this is a prerequisite for ensuring efficacy and reducing toxic side effects.

[0063] 1. Medicinal materials that must be processed: Fried radish seeds: When used raw, they have an ascending and dispersing effect; when fried, they have a descending effect, making them effective in regulating qi, resolving phlegm, relieving indigestion, and alleviating bloating. Fried radish seeds must be used.

[0064] Fried Bran-Stirred Fructus Aurantii Immaturus: Stir-frying with bran or plain stir-frying can mitigate its strong properties, reduce irritation to the gastrointestinal tract, and enhance its effects of regulating qi and relieving bloating. It must be stir-fried.

[0065] Stir-fried white peony root: Stir-frying makes its medicinal properties milder, better at nourishing blood and liver, and more suitable for the formula's overall approach of both tonifying and purging.

[0066] Magnolia officinalis: It is processed with fresh ginger, which can eliminate its irritation to the throat and enhance its effects of warming the middle, lowering qi, and relieving fullness.

[0067] Raw rhubarb: This formula aims to promote purgation, so raw rhubarb must be used. If processed rhubarb is used, the purgative effect will be weaker, and the purpose of the formula will be greatly changed.

[0068] 2. Specially treated medicinal materials: Dalbergia odorifera: It is a wood with a hard texture, and its components are not easily extracted by decoction. Before extraction, it must be ground into coarse powder or shaved into thin slices to facilitate the dissolution of the active ingredients.

[0069] Bupleurum chinense: As mentioned earlier, its volatile oil is the effective component and needs to be extracted separately.

[0070] This invention's formula is based on the core theories of Traditional Chinese Medicine: "the six fu organs function by unobstructed flow," "the interdependence of qi's ascending and descending functions," and "supporting the body's resistance and attacking pathogenic factors." Its principle aims to regulate the triple burner, promote the smooth flow of qi, clear the fu organs and eliminate turbidity, while simultaneously supporting the body's resistance. It primarily targets a series of complex symptoms that may be accompanied by deficiency of vital energy, stemming from qi stagnation, obstructed fu organ function, and internal retention of turbid pathogens. The entire formula primarily uses "descending and unblocking" as the main principle, "ascending and dispersing" as a supplementary principle, and "tonifying" as an adjunct, forming a precise system of coordinated ascending and descending functions, and combined attacking and tonifying effects.

[0071] The stir-fried radish seeds, stir-fried bitter orange peel, stir-fried bitter orange, raw licorice, white peony root, rhubarb, dried ginger, codonopsis, bupleurum, ginger-processed magnolia bark, and sandalwood in the prescription of this invention have a significant synergistic effect in treating postoperative gastrointestinal dysfunction. Reducing one or more of the ingredients significantly decreases the therapeutic activity of this traditional Chinese medicine enema composition.

[0072] As can be seen from the above technical solution, compared with the prior art, the present invention provides a traditional Chinese medicine enema composition, its preparation method and application, which has the following beneficial effects: 1) Highly targeted and fast-acting: Administered via enema, the drug can act directly on the colon and rectum, stimulating the intestinal wall nerve plexus, promoting intestinal peristalsis, and bypassing absorption barriers in the upper digestive tract. It is especially suitable for patients who cannot take oral medication after surgery.

[0073] 2) Significant therapeutic effect: As shown in clinical observation, the Chinese medicine composition of the present invention has an efficacy rate of up to 100% in treating postoperative gastrointestinal dysfunction, and can significantly shorten the time for patients to pass gas and defecate for the first time, and relieve abdominal distension.

[0074] 3) High safety: This formula is derived from classic Chinese medicine prescriptions. The formulation is rigorous, the medicinal properties are mild, and the enema administration mainly has local effects with few systemic side effects.

[0075] 4) Simple preparation and low cost: The raw materials are readily available, the preparation process is simple, and it is easy to standardize production and promote clinical application. Attached Figure Description

[0076] Figure 1 To compare the gastrointestinal transit function of rats in each group.

[0077] Figure 2 Comparison of serum Ghrelin levels in rats from different groups.

[0078] Note: In the same column of data, different letters indicate that the differences are significant. Detailed Implementation

[0079] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0080] When numerical ranges are given in the embodiments, it should be understood that, unless otherwise stated in the present invention, both endpoints of each numerical range and any value between the two endpoints may be selected. Unless otherwise defined, all technical and scientific terms used in this invention have the same meaning as commonly understood by one of ordinary skill in the art. In addition to the specific methods, apparatus, and materials used in the embodiments, based on the knowledge of the prior art possessed by one of ordinary skill in the art and the description of this invention, any prior art methods, apparatus, and materials similar to or equivalent to those described, apparatus, and materials in the embodiments of this invention may be used to implement the present invention.

[0081] Unless otherwise specified, in the following embodiments, reagents or instruments whose manufacturers are not indicated are all conventional products that can be purchased commercially.

[0082] Unless otherwise stated, the experimental methods, detection methods, and preparation methods disclosed in this invention all adopt conventional techniques in the fields of pharmacy, traditional Chinese medicine, analytical chemistry, medicine, and related fields.

[0083] In addition, the "water" mentioned in this invention includes any feasible water that can be used in the art, such as deionized water, distilled water, ion-exchanged water, double-distilled water, high-purity water, and purified water.

[0084] Example 1 A traditional Chinese medicine enema composition for the prevention or treatment of postoperative gastrointestinal dysfunction comprises the following ingredients: 20g of stir-fried radish seeds, 15g of stir-fried bitter orange peel, 20g of stir-fried bitter orange fruit, 30g of raw licorice root, 10g of white peony root, 15g of rhubarb, 20g of dried ginger, 15g of codonopsis root, 12g of bupleurum root, 30g of ginger-processed magnolia bark, and 3g of sandalwood.

[0085] The preparation method is as follows: S1. Soak all medicinal herbs in 8 times the amount of water for 40 minutes; S2. After bringing to a boil over high heat, simmer over low heat for 30 minutes, then filter to obtain the first filtrate and dregs. S3. Add 6 times the amount of water to the dregs, bring to a boil over high heat, then simmer over low heat for 20 minutes, filter, and obtain the second filtrate. S4. Combine the two filtrates and concentrate them to a concentration of 1.0 g / mL of raw medicinal material to obtain a traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction.

[0086] Example 2 A traditional Chinese medicine enema composition for the prevention or treatment of postoperative gastrointestinal dysfunction comprises the following ingredients: 10g of stir-fried radish seeds, 10g of stir-fried bitter orange peel, 15g of stir-fried bitter orange fruit, 20g of raw licorice root, 5g of white peony root, 10g of rhubarb, 10g of dried ginger, 10g of codonopsis root, 10g of bupleurum root, 20g of ginger-processed magnolia bark, and 1g of sandalwood.

[0087] The preparation method is as follows: S1. Soak all medicinal herbs in 10 times the amount of water for 60 minutes; S2. After bringing to a boil over high heat, simmer over low heat for 20 minutes, then filter to obtain the first filtrate and dregs. S3. Add 5 times the amount of water to the dregs, bring to a boil over high heat, then simmer over low heat for 25 minutes, filter, and obtain the second filtrate. S4. Combine the two filtrates and concentrate them to a concentration of 2.0 g / mL of raw medicinal material to obtain a traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction.

[0088] Example 3 A traditional Chinese medicine enema composition for the prevention or treatment of postoperative gastrointestinal dysfunction comprises the following ingredients: 15g of stir-fried radish seeds, 15g of stir-fried bitter orange peel, 20g of stir-fried bitter orange fruit, 25g of raw licorice root, 5g of white peony root, 15g of rhubarb, 10g of dried ginger, 10g of codonopsis root, 10g of bupleurum root, 25g of ginger-processed magnolia bark, and 3g of sandalwood.

[0089] The preparation method is as follows: S1. Soak all medicinal herbs in 8 times the amount of water for 40 minutes; S2. After bringing to a boil over high heat, simmer over low heat for 40 minutes, then filter to obtain the first filtrate and dregs. S3. Add 6 times the amount of water to the dregs, bring to a boil over high heat, then simmer over low heat for 20 minutes, filter, and obtain the second filtrate. S4. Combine the two filtrates and concentrate them to a concentration of 1.0 g / mL of raw medicinal material to obtain a traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction.

[0090] Example 4 A traditional Chinese medicine enema composition for the prevention or treatment of postoperative gastrointestinal dysfunction comprises the following ingredients: 20g of stir-fried radish seeds, 10g of stir-fried bitter orange peel, 10g of stir-fried bitter orange fruit, 30g of raw licorice root, 10g of white peony root, 10g of rhubarb, 15g of dried ginger, 15g of codonopsis root, 12g of bupleurum root, 20g of ginger-processed magnolia bark, and 1g of sandalwood.

[0091] The preparation method is as follows: S1. Soak all medicinal herbs in 6 times the amount of water for 35 minutes; S2. After bringing to a boil over high heat, simmer over low heat for 40 minutes, then filter to obtain the first filtrate and dregs. S3. Add three times the amount of water to the dregs, bring to a boil over high heat, then simmer over low heat for 15 minutes. Filter to obtain the second filtrate. S4. Combine the two filtrates and concentrate them to a concentration of 0.5 g / mL of raw medicinal material to obtain a traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction.

[0092] Example 5 A traditional Chinese medicine enema composition for the prevention or treatment of postoperative gastrointestinal dysfunction comprises the following ingredients: 15g of stir-fried radish seeds, 15g of stir-fried bitter orange peel, 20g of stir-fried bitter orange fruit, 20g of raw licorice root, 5g of white peony root, 15g of rhubarb, 12g of dried ginger, 10g of codonopsis root, 15g of bupleurum root, 30g of ginger-processed magnolia bark, and 3g of sandalwood.

[0093] The preparation method is as follows: S1. Soak all medicinal herbs in 10 times the amount of water for 60 minutes; S2. After bringing to a boil over high heat, simmer over low heat for 20 minutes, then filter to obtain the first filtrate and dregs. S3. Add 5 times the amount of water to the dregs, bring to a boil over high heat, then simmer over low heat for 25 minutes, filter, and obtain the second filtrate. S4. Combine the two filtrates and concentrate them to a concentration of 2.0 g / mL of raw medicinal material to obtain a traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction.

[0094] Example 6 A traditional Chinese medicine enema composition for the prevention or treatment of postoperative gastrointestinal dysfunction comprises the following ingredients: 10g of stir-fried radish seeds, 10g of stir-fried bitter orange peel, 15g of stir-fried bitter orange fruit, 25g of raw licorice root, 10g of white peony root, 10g of rhubarb, 20g of dried ginger, 15g of codonopsis root, 15g of bupleurum root, 20g of ginger-processed magnolia bark, and 1g of sandalwood.

[0095] The preparation method is as follows: S1. Soak all medicinal herbs in 6 times the amount of water for 35 minutes; S2. After bringing to a boil over high heat, simmer over low heat for 40 minutes, then filter to obtain the first filtrate and dregs. S3. Add three times the amount of water to the dregs, bring to a boil over high heat, then simmer over low heat for 15 minutes. Filter to obtain the second filtrate. S4. Combine the two filtrates and concentrate them to a concentration of 0.5 g / mL of raw medicinal material to obtain a traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction.

[0096] Example 7 A traditional Chinese medicine enema composition for the prevention or treatment of postoperative gastrointestinal dysfunction comprises the following ingredients: 20g of stir-fried radish seeds, 15g of stir-fried bitter orange peel, 15g of stir-fried bitter orange fruit, 30g of raw licorice root, 10g of white peony root, 10g of rhubarb, 15g of dried ginger, 10g of codonopsis root, 12g of bupleurum root, 20g of ginger-processed magnolia bark, and 3g of sandalwood.

[0097] The preparation method is as follows: S1. Soak all medicinal herbs in 8 times the amount of water for 40 minutes; S2. After bringing to a boil over high heat, simmer over low heat for 40 minutes, then filter to obtain the first filtrate and dregs. S3. Add 6 times the amount of water to the dregs, bring to a boil over high heat, then simmer over low heat for 20 minutes, filter, and obtain the second filtrate. S4. Combine the two filtrates and concentrate them to a concentration of 1.0 g / mL of raw medicinal material to obtain a traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction.

[0098] Example 8 A traditional Chinese medicine enema composition for the prevention or treatment of postoperative gastrointestinal dysfunction comprises the following ingredients: 10g of stir-fried radish seeds, 10g of stir-fried bitter orange peel, 20g of stir-fried bitter orange fruit, 20g of raw licorice root, 5g of white peony root, 15g of rhubarb, 20g of dried ginger, 15g of codonopsis root, 15g of bupleurum root, 30g of ginger-processed magnolia bark, and 1g of sandalwood.

[0099] The preparation method is as follows: S1. Soak all medicinal herbs in 8 times the amount of water for 40 minutes; S2. After bringing to a boil over high heat, simmer over low heat for 40 minutes, then filter to obtain the first filtrate and dregs. S3. Add 6 times the amount of water to the dregs, bring to a boil over high heat, then simmer over low heat for 20 minutes, filter, and obtain the second filtrate. S4. Combine the two filtrates and concentrate them to a concentration of 1.0 g / mL of raw medicinal material to obtain a traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction.

[0100] Comparative Example 1 20g of stir-fried radish seeds, 20g of stir-fried immature bitter orange, 30g of raw licorice root, 10g of white peony root, 15g of rhubarb, 20g of dried ginger, 15g of codonopsis root, 12g of bupleurum root, 30g of ginger-processed magnolia bark, and 3g of sandalwood.

[0101] Compared with Example 1, the difference is that it does not contain stir-fried bitter orange peel, while the other components and their amounts remain the same.

[0102] The preparation method is the same as in Example 1.

[0103] Comparative Example 2 20g of stir-fried radish seeds, 15g of stir-fried bitter orange peel, 20g of stir-fried bitter orange fruit, 30g of raw licorice root, 10g of white peony root, 15g of rhubarb, 20g of dried ginger, 12g of Bupleurum chinense, 30g of Magnolia officinalis, and 3g of Dalbergia odorifera.

[0104] Compared with Example 1, the difference is that it does not contain Codonopsis pilosula, while the other components and dosages remain the same.

[0105] The preparation method is the same as in Example 1.

[0106] Comparative Example 3 The Xiao Chengqi Decoction disclosed in the literature (Wei Zheng, Zhang Junping, Cai Xiaoping. Clinical observation of 80 cases of malignant intestinal obstruction treated with enema of modified Xiao Chengqi Decoction [J]. Chinese Clinical Research, 2013, 26(8):847-848) is as follows: rhubarb 6g, immature bitter orange 12g, magnolia bark 12g, areca peel 30g, radish seed 30g, perilla stem 30g, agastache stem 30g, stir-fried white peony root 30g, vinegar-processed corydalis rhizome 15g, ginger-processed pinellia tuber 9g, and prepared licorice root 10g.

[0107] Experimental Study on the Effect of the Herbal Enema Composition of the Present Invention on Gastrointestinal Function in Rats with Postoperative Intestinal Motility Disorders 1. Experimental Methods Forty-eight SPF-grade SD rats, weighing 150-170g, were given free access to food and water and were acclimatized for 7 days.

[0108] Rats were randomly divided into sham-operated group, model control group, experimental group 1, experimental group 2, experimental group 3, control group 1, control group 2, and control group 3 using a random number table method, with 6 rats in each group.

[0109] The sham surgery group underwent only laparotomy; the other groups established a postoperative intestinal motility disorder model in rats, as follows: Rats were fasted for 24 hours prior to surgery but allowed free access to water. They were anesthetized with isoflurane inhalation. Under aseptic conditions, a midline abdominal incision was made, and the small intestine and cecum were turned to the left and placed on saline-soaked gauze. Two cotton swabs were used to probe twice, approximately 10 minutes each, from the stomach and duodenum towards the ileocecal junction and part of the colon, allowing a small amount of intestinal contents to pass through the ileocecal junction. Significant congestion and edema of the intestinal wall were observed. After covering the small intestine with saline-soaked gauze for 10 minutes, the small intestine was returned to the abdominal cavity, and the abdominal wall was double-sutured.

[0110] Based on the reference clinical dose (190 g / d of crude drug), the equivalent dose for rats was calculated using the body surface area reduction method and the standard adult body weight of 60 kg.

[0111] After model establishment in Experimental Groups 1, 2, and 3, the herbal compositions from Examples 1, 2, and 3 were administered via enema at a dose of 19 g / d, respectively. Similarly, after model establishment in Control Groups 1, 2, and 3, the herbal compositions from Comparative Examples 1, 2, and 3 were administered via enema at a dose of 19 g / d, respectively. The sham-operated group and the model control group received an equal volume of physiological saline via enema after model establishment. All groups received an enema once daily for 7 consecutive days.

[0112] 2. Indicator Testing 2.1 Gastrointestinal transit function (GC) measurement After fasting for 24 h, rats were injected with 200 μL of FITC-labeled dextran (70 kDa) at a concentration of 6.25 mg / mL via gastric tube. 30 min later, the rats were euthanized under anesthesia, and the entire gastrointestinal tract was immediately removed and divided into 15 segments: stomach, 10 equal parts of small intestine, cecum, and 3 equal parts of colon. Each segment was washed with saline, and the FITC-labeled dextran washing solution was collected. The segments were centrifuged at 12000 r / min for 15 min, and the supernatant was collected. The absorbance of each segment was measured at a wavelength of 494 nm, and the percentage of absorbance for each segment was calculated (absorbance percentage of each segment = absorbance of each segment / total absorbance × 100).

[0113] According to the formula: Geometric mean = Σ (percentage of absorbance per segment × number of segments) / 100.

[0114] 2.2 Blood was drawn from the abdominal vein to detect serum Ghrelin levels.

[0115] 3. Statistical Methods Data processing was performed using GraphPad Prism 8.0 software, with the measurement data presented in... ±s indicates the mean. One-way ANOVA was used for comparisons between groups, and P < 0.05 was considered statistically significant.

[0116] 4. Experimental Results Comparison of gastrointestinal transit function among different groups of rats Table 1 Comparison of gastrointestinal transit function in rats of different groups Note: In the same column of data, different letters indicate that the differences are significant.

[0117] Compared with the sham-operated group, the gastrointestinal transit function of rats in the model control group was significantly reduced.

[0118] Compared with the model control group, the gastrointestinal transit function of rats in experimental groups 1, 2, 3, and the control group was significantly increased. The gastrointestinal transit function of rats in experimental groups 1, 2, and 3 was significantly better than that of control groups 1-3. The results are shown in Table 1. Figure 1 .

[0119] Comparison of serum Ghrelin levels in rats of different groups Table 2 Comparison of serum Ghrelin levels in rats of different groups Note: In the same column of data, different letters indicate that the differences are significant.

[0120] Compared with the sham-operated group, the serum Ghrelin level in the model control group was significantly reduced.

[0121] Compared with the model control group, the serum ghrelin levels in rats in experimental groups 1, 2, 3, and the control group were significantly increased. The serum ghrelin levels in experimental groups 1, 2, and 3 were significantly higher than those in control groups 1-3. Results are shown in Table 2. Figure 2 .

[0122] In summary, the herbal enema composition of the present invention significantly increases the gastrointestinal transit function of rats with postoperative intestinal motility disorders, increases the serum Ghrelin level in rats, and effectively improves postoperative intestinal motility disorders.

[0123] The efficacy of the traditional Chinese medicine compositions prepared in Examples 1-3 and Comparative Examples 1-3 was determined. It was found that, compared with Comparative Examples 1-3, Examples 1-3 showed more significant effects in increasing the gastrointestinal transit function of rats with postoperative intestinal motility disorders and increasing the serum ghrelin level in rats.

[0124] Further analysis suggests that stir-fried bitter orange peel and codonopsis pilosula may play key roles in this traditional Chinese medicine composition. When bupleurum chinense and scutellaria baicalensis are absent, the synergistic effect of the entire composition is weakened, resulting in a lower efficacy in treating postoperative gastrointestinal motility disorders compared to Examples 1-3, which include stir-fried bitter orange peel and codonopsis pilosula. This indicates that stir-fried bitter orange peel and codonopsis pilosula are indispensable components of this traditional Chinese medicine composition, playing a crucial role in enhancing overall efficacy.

[0125] Comparative Example 3 consisted of 6g rhubarb, 12g immature bitter orange, 12g magnolia bark, 30g areca peel, 30g radish seed, 30g perilla stem, 30g agastache stem, 30g stir-fried white peony root, 15g vinegar-processed corydalis rhizome, 9g ginger-processed pinellia tuber, and 10g prepared licorice root. The efficacy of Comparative Example 3 in treating postoperative gastrointestinal motility disorders was not as good as the herbal formula of this invention. Compared with Comparative Example 3, the herbal formula of this invention has significant technical advantages.

[0126] Clinical efficacy observation 120 patients with postoperative gastrointestinal dysfunction were selected and randomly divided into a control group and an observation group. There were no statistically significant differences in the general characteristics of the patients in each group (P>0.05), and they were comparable.

[0127] The control group received rhubarb and peony decoction enema treatment. The formula was: rhubarb 15 g, Glauber's salt 30 g (dissolved), peach kernel 15 g, peony bark 15 g, winter melon seed 15 g. The above Chinese herbs were soaked in 500 mL of water for 30 min and then decocted to 200 mL. After the temperature dropped to room temperature, the herbs were used for enema once a day for 7 days.

[0128] The observation group used the herbal enema composition from Example 1. After the temperature dropped to room temperature, the enema was administered once a day for 7 days.

[0129] Indicator Observation Clinical efficacy rate In the first week after surgery, the gastrointestinal dysfunction score was used for evaluation. The four-level scoring method was used for evaluation. The specific evaluation indicators included eating, nausea, vomiting, physical examination and symptom duration, which were assigned 0, 1, 2 and 3 points respectively, with a total score of 15 points.

[0130] Gastrointestinal dysfunction score reduction rate = (Pre-treatment gastrointestinal dysfunction score - Post-treatment gastrointestinal dysfunction score) / Pre-treatment gastrointestinal dysfunction score × 100%.

[0131] Significant effect: The patient's gastrointestinal dysfunction score reduction rate is 65% or higher; Effective: The patient's gastrointestinal dysfunction score reduction rate is 30%-65%; Not cured: The patient's gastrointestinal dysfunction score reduction rate is less than 30%. The total effective rate is significant effect + effective.

[0132] The gastrointestinal recovery of the two groups of patients was observed, including the time it took for bowel sounds to return to normal, the time for the first flatus after surgery, the time for the first defecation after surgery, and the time it took for their diet to return to normal.

[0133] Table 3 Comparison of efficacy rates between the two groups of patients One week after the operation, the clinical effective rate in the study group was 100%, which was higher than that in the control group (88.33%).

[0134] The statistical results of gastrointestinal recovery in the two groups of patients are shown in Table 4.

[0135] Table 4 Comparison of gastrointestinal recovery between the two groups of patients The recovery of gastrointestinal function in the observation group was significantly better than that in the control group, and the differences between the groups were obvious. P <0.05), indicating statistical significance.

[0136] Case 1: Mr. Zhang, male, 65 years old, underwent laparoscopic liver segment resection, cholecystectomy, choledochoenterostomy, and enteroenterostomy on August 13, 2025. Three days post-surgery, he had not passed gas or stool, and his abdomen was distended. Intra-abdominal pressure was 15 mmHg, accompanied by shortness of breath and wheezing. SpO2 fluctuated between 86% and 91% under 5 L / min oxygen therapy. The patient was unable to eat orally, and various medications to promote gastrointestinal motility were ineffective. After administering one dose of the prescribed enema for three days, he successively passed 1000 ml, 560 ml, and 380 ml of stool, after which intra-abdominal pressure returned to 6 mmHg, and oxygenation significantly improved. Case 2: Liu Mouyu, male, 77 years old, underwent robot-assisted radical esophagectomy on September 25, 2025. Postoperatively, he developed gastroparesis, and gastrointestinal decompression failed to improve his symptoms. He also experienced a small amount of reflux and aspiration. After 5 days of enema administration of the same prescription from the example, his gastrointestinal function completely returned to normal.

[0137] The various embodiments in this specification are described in a progressive manner, with each embodiment focusing on its differences from other embodiments. Similar or identical parts between embodiments can be referred to interchangeably. The solutions disclosed in the embodiments are described simply because they correspond to the methods disclosed in the embodiments; relevant parts can be found in the method section.

[0138] The above description of the disclosed embodiments enables those skilled in the art to make or use the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction, characterized in that, The herbal enema composition for treating postoperative gastrointestinal dysfunction comprises the following ingredients: 10-20g of stir-fried radish seeds, 10-15g of stir-fried bitter orange peel, 15-20g of stir-fried bitter orange, 20-30g of raw licorice root, 5-10g of stir-fried white peony root, 10-15g of raw rhubarb, 10-20g of dried ginger, 10-15g of codonopsis root, 10-12g of bupleurum root, 20-30g of ginger-processed magnolia bark, and 1-3g of sandalwood.

2. The traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction according to claim 1, characterized in that, The herbal enema composition for treating postoperative gastrointestinal dysfunction includes the following ingredients: 20 parts of stir-fried radish seeds, 15 parts of stir-fried bitter orange peel, 20 parts of stir-fried bitter orange, 30 parts of raw licorice root, 10 parts of white peony root, 15 parts of rhubarb, 20 parts of dried ginger, 15 parts of codonopsis root, 12 parts of bupleurum root, 30 parts of ginger-processed magnolia bark, and 3 parts of sandalwood.

3. The traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction according to claim 1, characterized in that, The herbal enema composition for treating postoperative gastrointestinal dysfunction includes the following ingredients: 10 parts of stir-fried radish seeds, 10 parts of stir-fried bitter orange peel, 15 parts of stir-fried bitter orange, 20 parts of raw licorice root, 5 parts of white peony root, 10 parts of rhubarb, 10 parts of dried ginger, 10 parts of codonopsis root, 10 parts of bupleurum root, 20 parts of ginger-processed magnolia bark, and 1 part of sandalwood.

4. The traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction according to claim 1, characterized in that, The herbal enema composition for treating postoperative gastrointestinal dysfunction includes the following ingredients: 15 parts of stir-fried radish seeds, 15 parts of stir-fried bitter orange peel, 20 parts of stir-fried bitter orange, 25 parts of raw licorice root, 5 parts of white peony root, 15 parts of rhubarb, 10 parts of dried ginger, 10 parts of codonopsis root, 10 parts of bupleurum root, 25 parts of ginger-processed magnolia bark, and 3 parts of sandalwood.

5. The traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction according to any one of claims 1-4, characterized in that, The preparation method of the traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction is as follows: S1, soak all medicinal materials in 5-10 times the amount of water for 30-60 minutes; S2. After bringing to a boil over high heat, simmer over low heat for 20-40 minutes, then filter to obtain the first filtrate and dregs. S3. Add 3-8 times the amount of water to the dregs, bring to a boil over high heat, then simmer over low heat for 15-30 minutes, filter, and obtain the second filtrate. S4. Combine the two filtrates and concentrate them to a concentration of 0.5-2.0 g / mL of raw medicinal material to obtain the enema decoction.

6. The traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction according to claim 5, characterized in that, The preparation method of the traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction is as follows: S1. Soak all medicinal herbs in 8 times the amount of water for 40 minutes; S2. After bringing to a boil over high heat, simmer over low heat for 30 minutes, then filter to obtain the first filtrate and dregs. S3. Add 6 times the amount of water to the dregs, bring to a boil over high heat, then simmer over low heat for 20 minutes, filter, and obtain the second filtrate. S4. Combine the two filtrates and concentrate them to a concentration of 1.0 g / mL of raw medicinal material to obtain the enema decoction.

7. The traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction according to claim 5, characterized in that, The preparation method of the traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction is as follows: S1. Soak all medicinal herbs in 5 times the amount of water for 30 minutes; S2. After bringing to a boil over high heat, simmer over low heat for 20 minutes, then filter to obtain the first filtrate and dregs. S3. Add 8 times the amount of water to the dregs, bring to a boil over high heat, then simmer over low heat for 30 minutes, filter, and obtain the second filtrate. S4. Combine the two filtrates and concentrate them to a concentration of 1.0 g / mL of raw medicinal material to obtain a traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction.

8. The traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction according to claim 5, characterized in that, The preparation method of the traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction is as follows: S1. Soak all medicinal herbs in 10 times the amount of water for 60 minutes; S2. After bringing to a boil over high heat, simmer over low heat for 20 minutes, then filter to obtain the first filtrate and dregs. S3. Add 5 times the amount of water to the dregs, bring to a boil over high heat, then simmer over low heat for 25 minutes, filter, and obtain the second filtrate. S4. Combine the two filtrates and concentrate them to a concentration of 2.0 g / mL of raw medicinal material to obtain a traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction.

9. The use of the traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction as described in any one of claims 1-4 in the preparation of a medicament for the prevention or treatment of postoperative gastrointestinal dysfunction.

Images