A composition for barrier repair, its method of preparation and use

Abstract

This invention, entitled "A Composition for Skin Barrier Repair, Its Preparation Method, and Its Application," belongs to the field of cosmetic technology. The technical problem to be solved is to provide a composition with dual effects of moisturizing and skin repair, and good stability. The key points of the technical solution are: using fresh yam and rehmannia root as raw materials, the yam and rehmannia root are extracted separately during the process, and the extraction temperature, time, type of enzyme, and molecular weight cutoff are controlled to obtain higher yields and better stability of the yam and rehmannia root extracts. The composition obtained by combining the obtained yam and rehmannia root extracts has a synergistic effect and a better barrier repair effect.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology, specifically relating to a composition for barrier repair, its preparation method, and its application. Background Technology

[0002] As a vital defense mechanism, the skin protects against environmental damage and maintains homeostasis. Many skin diseases are related to impaired skin barrier function. The skin barrier is the body's first line of defense against pathogens. Many external factors, such as ultraviolet radiation, air pollution, weather, and chemical irritants, can affect skin barrier function. Sensitive skin is also related to incomplete epidermal barrier function. A weakened epidermal barrier facilitates the penetration of irritants and allergens, increases epidermal moisture loss, and weakens the body's ability to resist external stimuli. In recent years, with the progress of modernization, increased environmental pollution, and a faster pace of life, the incidence of sensitive skin has been rising year by year, both domestically and internationally, and is prevalent in all regions of the world. Damaged skin barrier is a problem that plagues many people. Sensitive skin is prone to multiple skin problems or symptoms simultaneously, including impaired skin barrier function, decreased skin moisture content, increased transepidermal water loss, decreased sebum content, skin inflammation, dryness, and redness. Therefore, maintaining a healthy physiological state of the skin and repairing the skin barrier are particularly important. Currently, the cosmetics industry has made the development of products that can effectively repair the skin barrier a major research direction. Repairing the skin barrier, deeply moisturizing, and improving tolerance are all essential functional characteristics of anti-sensitive skincare products.

[0003] Relevant patent documents retrieved:

[0004] This document, published in China (CN102552080A) on September 11, 2013, discloses a traditional Chinese medicine composition with moisturizing properties. The composition comprises an extract of the following ingredients in parts by weight of water and / or solvent: Asparagus root: 20-50g, Rehmannia root: 20-50g, Dendrobium root: 10-40g, and Dioscorea root: 10-40g. This herbal extract and the herbal composition containing it have moisturizing effects and can be used directly for skin moisturizing or as an additive in cosmetics. It helps the skin resist dryness in dry environments, prevents moisture loss, moisturizes and beautifies the skin, leaving it radiant and supple. It is non-irritating to the skin and has a low cost. However, the repairing effect of this herbal composition is not ideal.

[0005] The publication, published in China (CN114939091A) on August 26, 2022, discloses a cosmetic composition that helps relieve sensitive skin, comprising 40-60 parts of natural water, 0.1-0.5 parts of allantoin, 1-5 parts of 1,3-propanediol, 0.01-1 parts of high molecular weight sodium hyaluronate, 0.01-1 parts of low molecular weight sodium hyaluronate, 5-10 parts of cabbage puree, 1-5 parts of mung bean sprout extract, 2-7 parts of yam puree, 6-12 parts of skin repair factor gel, 2-8 parts of broccoli extract, 5-13 parts of grape extract, 3-8 parts of angelica dahurica powder, and 1-5 parts of peppermint extract. This invention, by adding angelica powder, can relieve skin itching and allergies. It can proactively relieve allergic reactions and itching, and can treat the user's own skin itching. This avoids the situation where some cosmetic users have itching when using cosmetics and mistakenly believe that it is caused by an allergic reaction. However, the moisturizing effect of this application cannot meet the needs well.

[0006] Therefore, there is an urgent need to develop a composition and its preparation method that can effectively repair the skin barrier and also have a good moisturizing effect, so that it can achieve the dual effect of barrier repair and moisturizing when used in cosmetic products. Summary of the Invention

[0007] Based on the shortcomings of existing technologies, this invention uses yam and rehmannia as raw materials and obtains a composition through a specific preparation method. This composition has a relatively high content of yam extract and rehmannia extract, and the two plant extracts have a synergistic effect, which can effectively repair the skin barrier and has a good moisturizing effect.

[0008] In order to achieve the above objectives, the present invention aims to provide:

[0009] A composition for barrier repair, and related technologies thereof, to solve the technical problems of existing technologies that cannot simultaneously achieve both repair and moisturizing effects, and that have poor product stability, or a combination thereof.

[0010] This invention obtains a composition with high content of effective ingredients from yam and rehmannia extracts, synergistic effects, dual functions of repair and moisturization, and good product stability by using yam and rehmannia extracts as raw materials.

[0011] Terminology Explanation:

[0012] Unless otherwise defined, all technical terms in this document have the same meanings as commonly understood by one of ordinary skill in the art to which the subject matter of the claims pertains. Unless otherwise stated, all patents, patent inventions, and publications cited in this document are incorporated herein by reference in their entirety. If multiple definitions exist for terms in this document, the definitions in this chapter shall prevail.

[0013] It should be understood that the above brief description and the following detailed description are exemplary and for illustrative purposes only, and do not limit the subject matter of the invention in any way. In this invention, the singular is used in conjunction with the plural unless otherwise specifically stated. It should also be noted that, unless otherwise stated, the use of “or” or “or” means “and / or”. Furthermore, the use of the term “comprising” and other forms such as “including,” “containing,” and “contains” are not limiting.

[0014] Unless otherwise stated, conventional methods within the scope of the art, such as mixing and stirring, shall be used.

[0015] Unless specifically defined herein, the use of various commercially available products herein employs standard techniques. For example, they may be implemented in a manner known in the art or as described in this invention. The techniques and methods described herein can generally be implemented according to conventional methods well known in the art, based on the descriptions in the various summary and more specific documents cited and discussed in this specification.

[0016] The terms “optional / arbitrary” or “optionally / arbitrarily” mean that the event or situation described below may or may not occur, including both the occurrence and non-occurrence of the event or situation.

[0017] The term "enzymatic hydrolysis" as used in this article refers to the decomposition process catalyzed by enzymes, which is the process of breaking down large molecular compounds into smaller molecular compounds.

[0018] In a first aspect, the present invention provides a composition for barrier repair, said composition comprising yam extract and rehmannia extract.

[0019] The mass ratio of the yam extract to the rehmannia extract is 3-5:1.

[0020] Preferably, the mass ratio of the yam extract to the rehmannia extract is 3-4:1;

[0021] Preferably, the mass ratio of the yam extract to the rehmannia extract is any value or range between 3 and 5:1, and can be selected from 3:1, 3.5:1, 4:1, 4.5:1 or 5:1.

[0022] As the most preferred embodiment, the mass ratio of the yam extract to the rehmannia extract is 4:1.

[0023] The preparation method of the yam extract is as follows:

[0024] Take fresh yam slices, steam them under normal pressure for 30 minutes, add 10-15 times the amount of water and extract by gentle boiling for 30-90 minutes, add amylase, and after full enzymatic hydrolysis, filter until clear, dehydrate and cut off the extract with a molecular weight of 3KD or higher using an ultrafiltration membrane, dehydrate to 0.4-0.6 times the weight of the added fresh yam, add glucomannanase with a molecular weight greater than 5KD to 150-250U / g, enzymatically hydrolyze for 25-35 minutes, ultrafilter to cut off the extract with a molecular weight of less than 5KD, and dehydrate and concentrate through a reverse osmosis membrane to a final volume of 50% solids to obtain yam extract.

[0025] The amount of water added is 10-15 times; preferably 12-15 times.

[0026] Preferably, the amount of water added is any value or range between 10 and 15 times, and can be selected from 10 times, 11 times, 12 times, 13 times, 14 times or 15 times;

[0027] As the most preferred embodiment, the amount of water added is 12 times.

[0028] The extraction time is 30-90 minutes; preferably 40-80 minutes, and even more preferably 50-70 minutes;

[0029] Preferably, the extraction time is any point or range value between 30 and 90 minutes, and can be selected from 30 minutes, 35 minutes, 40 minutes, 45 minutes, 50 minutes, 55 minutes, 60 minutes, 65 minutes, 70 minutes, 75 minutes, 80 minutes, 85 minutes or 90 minutes;

[0030] As the most preferred option, the extraction time is 60 minutes.

[0031] The amount of amylase added is 0.08-0.12% of the weight of fresh yam;

[0032] Preferably, the amount of amylase added is 0.09-0.11% of the weight of the fresh yam;

[0033] Preferably, the amount of amylase added is any value or range between 0.08% and 0.12% of the mass of the fresh yam, and can be selected from 0.08%, 0.09%, 0.1%, 0.11%, or 0.12%.

[0034] As the most preferred embodiment, the amount of amylase added is 0.1% of the mass of the fresh yam.

[0035] The amylase is used for enzymatic hydrolysis at a temperature of 50-65℃; preferably 55-60℃.

[0036] Preferably, the temperature at which the amylase hydrolyzes the amylase is any point or range between 50-65°C, and can be selected from 50°C, 52°C, 55°C, 58°C, 60°C, 62°C or 65°C.

[0037] As the most preferred embodiment, the amylase is subjected to enzymatic hydrolysis at a temperature of 60°C.

[0038] The amylase hydrolysis time is 20-40 min; preferably 30-35 min.

[0039] Preferably, the time for the amylase to hydrolyze the amylase is any value or range between 20 and 40 min, and can be selected from 20 min, 25 min, 30 min, 35 min or 40 min;

[0040] As the most preferred embodiment, the amylase is used for enzymatic hydrolysis for 30 minutes.

[0041] The dehydration is carried out to 0.4-0.6 times the weight of the added fresh yam; preferably 0.5-0.6 times.

[0042] Preferably, the dehydration to any point or range between 0.4 and 0.6 times the mass of the added fresh yam can be selected from 0.4 times, 0.45 times, 0.5 times, 0.55 times, or 0.6 times.

[0043] As the most preferred embodiment, the dehydration is carried out to 0.5 times the mass of the fresh yam.

[0044] The addition of glucomannanase with a molecular weight greater than 5KD to a concentration of 150-250 U / g is preferred; ideally, it should be 180-220 U / g.

[0045] Preferably, the added glucomannanase with a molecular weight greater than 5KD is selected from any point or range between 150-250U / g, including 150U / g, 160U / g, 170U / g, 180U / g, 190U / g, 200U / g, 210U / g, 220U / g, 230U / g, 240U / g, or 250U / g.

[0046] As the most preferred embodiment, the addition of glucomannanase with a molecular weight greater than 5KD to 200U / g is preferred.

[0047] The enzymatic hydrolysis time is 25-35 minutes; preferably 30-35 minutes.

[0048] Preferably, the enzymatic hydrolysis time is any value or range between 25 and 35 minutes, and can be selected from 25 minutes, 26 minutes, 27 minutes, 28 minutes, 29 minutes, 30 minutes, 31 minutes, 32 minutes, 33 minutes, 34 minutes or 35 minutes;

[0049] As the most preferred embodiment, the enzymatic hydrolysis time is 30 minutes.

[0050] As a preferred embodiment, the preparation method of the yam extract includes the following steps:

[0051] Take fresh yam slices, steam them under normal pressure for 30 minutes, add 12 times the amount of water and extract by gentle boiling for 60 minutes. Add 0.1% amylase by weight of fresh yam, and fully enzymatically hydrolyze at 60℃ for 30 minutes. Filter until clear, dehydrate and cut off the extract with a molecular weight of 3KD or higher using an ultrafiltration membrane, dehydrate to 0.5 times the weight of the added fresh yam, add glucomannanase with a molecular weight greater than 5KD to 200U / g, enzymatically hydrolyze at 60℃ for 30 minutes, ultrafilter to cut off the extract with a molecular weight of less than 5KD, and dehydrate and concentrate through a reverse osmosis membrane to a final volume of 50% solids to obtain yam extract.

[0052] The preparation method of the Rehmannia glutinosa extract includes the following steps:

[0053] Take fresh Rehmannia glutinosa, crush and homogenize the tissue, remove insoluble matter to obtain fresh Rehmannia glutinosa juice, use an ultrafiltration membrane to cut off the juice with a molecular weight of less than 150nm, use a 30nm ultrafiltration membrane to dehydrate to 15-25% of the fresh Rehmannia glutinosa to obtain concentrated Rehmannia glutinosa juice, use a 30nm permeate, stir and heat at 80-100℃ for 2-3 hours, use an ultrafiltration membrane to cut off the extract with a molecular weight of less than 5KD, concentrate through a reverse osmosis membrane, add the total amount of Rehmannia glutinosa juice to make up to 50% solids to obtain Rehmannia glutinosa extract.

[0054] The stirring and heating temperature is 80-100℃; preferably 80-95℃.

[0055] Preferably, the temperature of the stirring and heating is any point or range between 80-100℃, and can be selected from 80℃, 85℃, 90℃, 95℃ or 100℃.

[0056] As the most preferred embodiment, the stirring and heating temperature is 90°C.

[0057] The stirring and heating time is 2-3 hours; preferably 2.5-3 hours.

[0058] Preferably, the stirring and heating time is any value or range between 2 and 3 hours, and can be selected from 2 hours, 2.5 hours or 3 hours.

[0059] As the most preferred embodiment, the stirring and heating time is 3 hours.

[0060] As a preferred embodiment, the preparation method of the Rehmannia glutinosa extract includes the following steps:

[0061] Fresh Rehmannia glutinosa was crushed, homogenized, and insoluble matter was removed to obtain fresh Rehmannia glutinosa juice. The juice with a molecular weight of less than 150 nm was removed by ultrafiltration membrane, and the water content of the fresh Rehmannia glutinosa was reduced to 20% by 30 nm ultrafiltration membrane to obtain concentrated Rehmannia glutinosa juice. The permeate with a molecular weight of 30 nm was stirred and heated at 90°C for 2.5 h, and then ultrafiltration membrane was used to remove the extract with a molecular weight of less than 5 KD. The extract was concentrated by reverse osmosis membrane, and the volume of Rehmannia glutinosa juice was added to make up to 50% solids to obtain Rehmannia glutinosa extract.

[0062] Secondly, the present invention provides a method for preparing the above-mentioned composition for barrier repair.

[0063] The method is as follows: take yam extract and rehmannia extract, mix them, then add glycerin, 1,2-hexanediol, p-hydroxyacetophenone and water, and mix well to obtain the final product.

[0064] Thirdly, the present invention provides the use of the above-described composition for barrier repair in the preparation of cosmetics with barrier repair function.

[0065] The cosmetics mentioned are lotions, serums, face masks, or sunscreens.

[0066] Examples 1-3 of this invention at least support the protection scope of the mass ratio of yam extract and rehmannia extract, the preparation method of yam extract, and the preparation method of rehmannia extract.

[0067] The "mass ratio of yam extract to rehmannia extract" is derived from the aforementioned explanation and / or the corresponding technical features 5:1, 4:1, 3:1, etc. in Examples 1-3, summarized by the common feature "the mass ratio of yam extract to rehmannia extract is 3-5:1". Therefore, those skilled in the art can reasonably infer that the subordinate concept of the technical feature "the mass ratio of yam extract to rehmannia extract is 3-5:1", the substantially equivalent technical means, and the technical means that can replace the mass ratio of yam extract to rehmannia extract within the scope of conventional technical means and common knowledge based on the existing technical level should all fall within the protection scope of this invention. For example, replacing the mass ratio with 2.5:1 or 3.5:1 while keeping other technical features unchanged still falls within the protection scope of this invention.

[0068] The "preparation method of yam extract" described herein is summarized from the common features of "water addition of 10-15 times", "extraction time of 30-90 minutes", and "amylase addition of 0.08-0.12% of the mass of fresh yam" in the foregoing explanation and / or Examples 1-3. Therefore, those skilled in the art can reasonably infer that the subordinate concepts of the technical features of water addition, extraction time, and starch addition, the substantially equivalent technical means, and the technical means that can replace pure water based on existing technology and common knowledge should all fall within the scope of protection of this invention. For example, if other technical features remain unchanged, replacing the water addition with 11 times or 13 times, replacing the extraction time with 40 minutes or 50 minutes, and adding amylase at 0.09% or 0.12% of the mass of fresh yam, etc., still falls within the scope of protection of this invention.

[0069] The "preparation method of Rehmannia glutinosa extract" described herein is summarized from the common feature of "stirring and heating time of 80-100℃ and 2-3h" in the foregoing explanation and / or Examples 1-3. Therefore, those skilled in the art can reasonably infer that the subordinate concepts of the technical feature temperature and time, the substantially equivalent technical means, and the technical means that can replace the temperature and time of enzymatic hydrolysis within the scope of conventional technical means and common knowledge based on the existing technical level should all fall within the protection scope of this invention. For example, if the stirring and heating time is replaced with 80℃ or 82℃, or 2h or 4h, while other technical features remain unchanged, it still falls within the protection scope of this invention.

[0070] The beneficial effects of this invention are as follows:

[0071] The present invention has at least the following beneficial effects:

[0072] Compared with existing technologies, this invention has better technical effects in terms of barrier repair and moisturizing.

[0073] According to experimental tests, the composition obtained by mixing the yam extract and rehmannia extract prepared in this invention according to the specified ratio has a better synergistic effect, which significantly increases the water content of the stratum corneum of the skin and improves the repair rate to over 69%; and significantly reduces the transdermal water dispersion value and improves the repair rate to over 30%.

[0074] Furthermore, based on the present invention:

[0075] Based on the comparison of Examples 1-3 and Comparative Examples 1-11, the present invention utilizes a specific preparation method to combine yam extract and rehmannia extract in a specific ratio, achieving a new technical effect through synergistic enhancement, namely, better repair and moisturizing effects. The combined technical effect is superior to the sum of the effects of each individual technique.

[0076] In addition, the present invention employs the following methods in its implementation:

[0077] Dioscorea opposita and Rehmannia glutinosa were extracted separately, and the extraction temperature, time, enzyme type, and molecular weight cutoff were controlled to obtain higher yields of yam extract and Rehmannia glutinosa extract. The yields of both yam extract and Rehmannia glutinosa extract could reach more than 30%, and the resulting composition had better low-temperature, high-temperature, and light-induced stability. Detailed Implementation

[0078] The following non-limiting embodiments are intended to enable those skilled in the art to gain a more comprehensive understanding of the present invention, but do not limit the invention in any way. The following content is merely an exemplary description of the scope of protection claimed by the present invention, and those skilled in the art can make various changes and modifications to the present invention based on the disclosed content, and such changes should also fall within the scope of protection claimed by the present invention.

[0079] The present invention will be further described below by way of specific embodiments. Unless otherwise specified, all instruments, devices, equipment, reagents, products, etc., used in the embodiments of the present invention are obtained through conventional commercial means.

[0080] The manufacturers and models of the raw materials used in the following examples are as follows:

[0081] Amylase: Purchased from Xi'an Tianmao Baoding Biotechnology Co., Ltd., batch number: 20250908; Glucomannanase: Beijing Nuon Biotechnology Co., Ltd., batch number: 2025091105; 1,2-Pentanediol: Purchased from Tor Specialty Chemicals (Zhenjiang) Co., Ltd.; Acrylic (ester) compounds / C10-30 alkanol acrylate crosspolymers: Purchased from Lubrizol Advanced Materials, Inc.; p-Hydroxyacetophenone: Purchased from Symrise Fragrance & Flavor (Nantong) Co., Ltd.; Arginine: Purchased from Wuxi Jinghai Amino Acids Co., Ltd.

[0082] Example 1: A method for preparing a composition for barrier repair

[0083] The composition is prepared by the following method:

[0084] 1. Take 100g of fresh yam slices, steam at normal pressure for 30 minutes, then add 1000g of water and extract by gentle boiling for 30 minutes; add 0.1g of amylase, hydrolyze at 60℃ for 30 minutes, and filter until clear; dehydrate and cut off the extract with a molecular weight of 3KD or higher using a 3KD ultrafiltration membrane, and dehydrate to 45g; add glucomannanase with a molecular weight greater than 5KD to 150U / g, hydrolyze at 60℃ for 35 minutes, ultrafilter to cut off the extract with a molecular weight of less than 5KD, and dehydrate and concentrate through a reverse osmosis membrane to a final volume of 50% solids to obtain 30g of yam extract;

[0085] 2. Take 100g of fresh Rehmannia glutinosa, crush it, homogenize the tissue, remove insoluble matter, and obtain fresh Rehmannia glutinosa juice; use an ultrafiltration membrane to cut off the juice with a molecular weight of less than 150nm, and dehydrate it to 18g using a 30nm ultrafiltration membrane to obtain concentrated Rehmannia glutinosa juice; use a 30nm permeate, stir and heat at 80℃ for 2h, use an ultrafiltration membrane to cut off the extract with a molecular weight of less than 5KD, concentrate it through a reverse osmosis membrane, add the above total concentrated Rehmannia glutinosa juice to make up to 50% solids to obtain 29g of Rehmannia glutinosa extract;

[0086] 3. Take 10g of yam extract and 2g of rehmannia extract, add 5g of glycerin, 0.5g of 1,2-hexanediol and 0.5g of p-hydroxyacetophenone, and add water to make up to 109g to obtain the composition.

[0087] Example 2: A method for preparing a composition for barrier repair

[0088] The composition is prepared by the following method:

[0089] 1. Take 100g of fresh yam slices, steam at normal pressure for 30 minutes, add 1200g of water and extract by gentle boiling for 60 minutes; add 0.1g of amylase, enzymatically hydrolyze at 60℃ for 30 minutes, filter until clear; dehydrate and cut off the extract with a molecular weight of 3KD or higher using a 3KD ultrafiltration membrane, dehydrate to 50g; add glucomannanase with a molecular weight greater than 5KD to 200U / g, enzymatically hydrolyze at 60℃ for 30 minutes, ultrafilter to cut off the extract with a molecular weight of less than 5KD, and dehydrate and concentrate to 50% solids using a reverse osmosis membrane to obtain 32g of yam extract;

[0090] 2. Take 100g of fresh Rehmannia glutinosa, crush and homogenize the tissue, remove insoluble matter to obtain fresh Rehmannia glutinosa juice; use an ultrafiltration membrane to cut off the juice with a molecular weight of less than 150nm, and dehydrate it to 20g using a 30nm ultrafiltration membrane to obtain concentrated Rehmannia glutinosa juice; use a 30nm permeate, stir and heat at 90℃ for 2.5h, use an ultrafiltration membrane to cut off the extract with a molecular weight of less than 5KD, concentrate it through a reverse osmosis membrane, and add the above total concentrated Rehmannia glutinosa juice to make up to 50% solids to obtain 30g of Rehmannia glutinosa extract;

[0091] 3. Take 12g of yam extract and 3g of rehmannia extract, add 5g of glycerin, 0.5g of 1,2-hexanediol and 0.5g of p-hydroxyacetophenone, and add water to 136g to obtain the composition.

[0092] Example 3: A method for preparing a composition for barrier repair

[0093] The composition is prepared by the following method:

[0094] 1. Take 100g of fresh yam slices, steam at normal pressure for 30 minutes, add 1500g of water and extract by gentle boiling for 90 minutes; add 0.1g of amylase, enzymatically hydrolyze at 60℃ for 30 minutes, filter until clear; dehydrate and cut off the extract with a molecular weight of 3KD or higher using a 3KD ultrafiltration membrane, dehydrate to 55g; add glucomannanase with a molecular weight greater than 5KD to 250U / g, enzymatically hydrolyze at 60℃ for 25 minutes, ultrafilter to cut off the extract with a molecular weight of less than 5KD, and dehydrate and concentrate through a reverse osmosis membrane to a final volume of 50% solids to obtain 33g of yam extract;

[0095] 2. 100g of fresh Rehmannia glutinosa is crushed, homogenized, and insoluble matter is removed to obtain fresh Rehmannia glutinosa juice. The juice with a molecular weight of less than 150nm is removed by ultrafiltration membrane, and the water is dehydrated to 28g by 30nm ultrafiltration membrane to obtain concentrated Rehmannia glutinosa juice. The permeate with a molecular weight of 30nm is stirred and heated at 95℃ for 3 hours, and then ultrafiltration membrane is used to remove the extract with a molecular weight of less than 5KD. The extract is concentrated by reverse osmosis membrane, and the above total concentrated Rehmannia glutinosa juice is added to make up to 50% solids to obtain 31g of Rehmannia glutinosa extract.

[0096] 3. Take 12g of yam extract and 4g of rehmannia extract, add 5g of glycerin, 0.5g of 1,2-hexanediol and 0.5g of p-hydroxyacetophenone, and add water to 145g to obtain the composition.

[0097] Comparative Example 1:

[0098] The difference from Example 2 is that only yam extract is used, specifically:

[0099] 1. Take 100g of fresh yam slices, steam at normal pressure for 30 minutes, add 1200g of water and extract by gentle boiling for 60 minutes; add 0.1g of amylase, enzymatically hydrolyze at 60℃ for 30 minutes, filter until clear; dehydrate and cut off the extract with a molecular weight of 3KD or higher using a 3KD ultrafiltration membrane, dehydrate to 50g; add glucomannanase with a molecular weight greater than 5KD to 200U / g, enzymatically hydrolyze at 60℃ for 30 minutes, ultrafilter to cut off the extract with a molecular weight of less than 5KD, and dehydrate and concentrate to 50% solids using a reverse osmosis membrane to obtain 32g of yam extract;

[0100] 2. Take 11g of yam extract, add 5g of glycerin, 0.5g of 1,2-hexanediol and 0.5g of p-hydroxyacetophenone, and add water to 100g to obtain yam extract solution.

[0101] Comparative Example 2:

[0102] The difference from Example 2 is that only Rehmannia glutinosa extract is used, specifically:

[0103] 1. Take 100g of fresh Rehmannia glutinosa, crush and homogenize the tissue, remove insoluble matter to obtain fresh Rehmannia glutinosa juice; use an ultrafiltration membrane to cut off the juice with a molecular weight of less than 150nm, and dehydrate it to 20g using a 30nm ultrafiltration membrane to obtain concentrated Rehmannia glutinosa juice; use a 30nm permeate, stir and heat at 90℃ for 2.5h, use an ultrafiltration membrane to cut off the extract with a molecular weight of less than 5KD, concentrate it through a reverse osmosis membrane, and add the above total concentrated Rehmannia glutinosa juice to make up to 50% solids to obtain 30g of Rehmannia glutinosa extract;

[0104] 2. Take 11g of Rehmannia glutinosa extract, add 5g of glycerin, 0.5g of 1,2-hexanediol, and 0.5g of p-hydroxyacetophenone, and add water to make up to 100g to obtain Rehmannia glutinosa extract.

[0105] Comparative Example 3:

[0106] The difference from Example 2 is that the yam extract and rehmannia extract are replaced with bletilla striata extract, specifically:

[0107] 1. Take 100g of Bletilla striata and add 1000g of water, and extract by gentle boiling for 60 minutes; after filtering the filtrate until clear, concentrate it under reduced pressure until the solid content is 50% to obtain 38g of Bletilla striata extract;

[0108] 2. Take 15g of Bletilla striata extract, add 5g of glycerin, 0.5g of 1,2-hexanediol, and 0.5g of p-hydroxyacetophenone, and add water to make up to 100g to obtain Bletilla striata extract.

[0109] Comparative Example 4:

[0110] The difference from Example 2 lies in the specific parameters extracted, which are different:

[0111] 1. Take 100g of fresh yam slices, steam at normal pressure for 30 minutes, add 800g of water and extract by gentle boiling for 30 minutes; add 0.1g of amylase, enzymatically hydrolyze at 60℃ for 30 minutes, filter until clear; dehydrate and cut off the extract with a molecular weight of 3KD or higher using a 3KD ultrafiltration membrane, dehydrate to 50g; add glucomannanase with a molecular weight greater than 5KD to 200U / g, enzymatically hydrolyze at 60℃ for 30 minutes, ultrafilter to cut off the extract with a molecular weight of less than 5KD, and dehydrate and concentrate through a reverse osmosis membrane to a final volume of 50% solids to obtain 20g of yam extract;

[0112] 2. Take 100g of fresh Rehmannia glutinosa, crush and homogenize the tissue, remove insoluble matter to obtain fresh Rehmannia glutinosa juice; use an ultrafiltration membrane to cut off the juice with a molecular weight of less than 150nm, and dehydrate it to 20g using a 30nm ultrafiltration membrane to obtain concentrated Rehmannia glutinosa juice; use a 30nm permeate, stir and heat at 60℃ for 0.5h, use an ultrafiltration membrane to cut off the extract with a molecular weight of less than 5KD, concentrate it through a reverse osmosis membrane, and add the above total concentrated Rehmannia glutinosa juice to make up to 50% solids to obtain 30g of Rehmannia glutinosa extract;

[0113] 3. Take 12g of yam extract and 3g of rehmannia extract, add 5g of glycerin, 0.5g of 1,2-hexanediol and 0.5g of p-hydroxyacetophenone, and add water to 136g to obtain the composition.

[0114] Comparative Example 5:

[0115] The difference from Example 2 lies in the specific parameters extracted, which are different:

[0116] 1. Take 100g of fresh yam slices, steam them under normal pressure for 30 minutes, add 1200g of water and extract by gentle boiling for 60 minutes; dehydrate and cut off the extract with a molecular weight of 3KD or higher using a 3KD ultrafiltration membrane, and dehydrate to 50g; cut off the extract with a molecular weight of less than 5KD by ultrafiltration, and dehydrate and concentrate it to 50% solids using a reverse osmosis membrane to obtain 15g of yam extract;

[0117] 2. Take 100g of fresh Rehmannia glutinosa, crush and homogenize the tissue, remove insoluble matter to obtain fresh Rehmannia glutinosa juice; use an ultrafiltration membrane to cut off the juice with a molecular weight of less than 150nm, and dehydrate it to 20g using a 30nm ultrafiltration membrane to obtain concentrated Rehmannia glutinosa juice; use a 30nm permeate, stir and heat at 90℃ for 2.5h, use an ultrafiltration membrane to cut off the extract with a molecular weight of less than 5KD, concentrate it through a reverse osmosis membrane, and add the above total concentrated Rehmannia glutinosa juice to make up to 50% solids to obtain 30g of Rehmannia glutinosa extract;

[0118] 3. Take 12g of yam extract and 3g of rehmannia extract, add 5g of glycerin, 0.5g of 1,2-hexanediol and 0.5g of p-hydroxyacetophenone, and add water to 136g to obtain the composition.

[0119] Comparative Example 6:

[0120] The difference from Example 2 lies in the specific parameters extracted, which are different:

[0121] 1. Take 100g of fresh yam slices, steam at normal pressure for 30 minutes, add 1200g of water and extract by gentle boiling for 60 minutes; add 0.1g of amylase, enzymatically hydrolyze at 60℃ for 30 minutes, filter until clear; dehydrate and cut off the extract with a molecular weight of 3KD or higher using a 3KD ultrafiltration membrane, dehydrate to 50g; add glucomannanase to 200U / g, enzymatically hydrolyze at 60℃ for 30 minutes, ultrafilter to cut off the extract with a molecular weight of less than 5KD, and dehydrate and concentrate through a reverse osmosis membrane to a final volume of 50% solids to obtain 35g of yam extract;

[0122] 2. Take 100g of fresh Rehmannia glutinosa, crush and homogenize the tissue, remove insoluble matter to obtain fresh Rehmannia glutinosa juice; use an ultrafiltration membrane to cut off the juice with a molecular weight of less than 150nm, and dehydrate it to 20g using a 30nm ultrafiltration membrane to obtain concentrated Rehmannia glutinosa juice; use a 30nm permeate, stir and heat at 90℃ for 2.5h, use an ultrafiltration membrane to cut off the extract with a molecular weight of less than 5KD, concentrate it through a reverse osmosis membrane, and add the above total concentrated Rehmannia glutinosa juice to make up to 50% solids to obtain 30g of Rehmannia glutinosa extract;

[0123] 3. Take 12g of yam extract and 3g of rehmannia extract, add 5g of glycerin, 0.5g of 1,2-hexanediol and 0.5g of p-hydroxyacetophenone, and add water to 136g to obtain the composition.

[0124] Comparative Example 7:

[0125] The difference from Example 2 lies in the specific parameters extracted, which are different:

[0126] 1. Take 100g of fresh yam slices, steam at normal pressure for 30 minutes, add 1200g of water and extract by gentle boiling for 60 minutes; add 0.1g of amylase, enzymatically hydrolyze at 60℃ for 30 minutes, filter until clear; dehydrate and cut off the extract with a molecular weight of 3KD or higher using a 3KD ultrafiltration membrane, dehydrate to 50g; add glucomannanase with a molecular weight greater than 5KD to 200U / g, enzymatically hydrolyze at 60℃ for 30 minutes, ultrafilter to cut off the extract with a molecular weight of less than 5KD, and dehydrate and concentrate to 50% solids using a reverse osmosis membrane to obtain 32g of yam extract;

[0127] 2. Take 100g of fresh Rehmannia glutinosa, crush it, homogenize the tissue, remove insoluble matter, and obtain fresh Rehmannia glutinosa juice; use an ultrafiltration membrane to cut off the juice with a particle size smaller than 150nm, and use a 30nm ultrafiltration membrane to dehydrate to 20g, to obtain concentrated Rehmannia glutinosa juice; adjust the volume of concentrated Rehmannia glutinosa juice to 50% solids to obtain 20g of Rehmannia glutinosa extract.

[0128] 3. Take 12g of yam extract and 3g of rehmannia extract, add 5g of glycerin, 0.5g of 1,2-hexanediol and 0.5g of p-hydroxyacetophenone, and add water to 136g to obtain the composition.

[0129] Comparative Example 8:

[0130] The difference from Example 2 lies in the specific parameters extracted, which are different:

[0131] 1. Take 100g of fresh yam slices, steam at normal pressure for 30 minutes, add 1200g of water and extract by gentle boiling for 60 minutes; add 0.1g of amylase, enzymatically hydrolyze at 60℃ for 30 minutes, filter until clear; dehydrate and cut off the extract with a molecular weight of 3KD or higher using a 3KD ultrafiltration membrane, dehydrate to 50g; add glucomannanase with a molecular weight greater than 5KD to 200U / g, enzymatically hydrolyze at 60℃ for 30 minutes, ultrafilter to cut off the extract with a molecular weight of less than 5KD, and dehydrate and concentrate to 50% solids using a reverse osmosis membrane to obtain 32g of yam extract;

[0132] 2. Take 100g of fresh Rehmannia glutinosa, crush it, homogenize the tissue, remove insoluble matter, and obtain fresh Rehmannia glutinosa juice; use an ultrafiltration membrane to cut off the permeate with a molecular weight of less than 30nm, stir and heat at 90℃ for 2.5h, use an ultrafiltration membrane to cut off the extract with a molecular weight of less than 5KD, concentrate it through a reverse osmosis membrane, add water to make up to 50% solids to obtain 10g of Rehmannia glutinosa extract.

[0133] 3. Take 12g of yam extract and 3g of rehmannia extract, add 5g of glycerin, 0.5g of 1,2-hexanediol and 0.5g of p-hydroxyacetophenone, and add water to 136g to obtain the composition.

[0134] Comparative Example 9:

[0135] The difference from Example 2 is that the mass ratio of yam extract and rehmannia extract is different, specifically:

[0136] 1. Take 100g of fresh yam slices, steam at normal pressure for 30 minutes, add 1200g of water and extract by gentle boiling for 60 minutes; add 0.1g of amylase, enzymatically hydrolyze at 60℃ for 30 minutes, filter until clear; dehydrate and cut off the extract with a molecular weight of 3KD or higher using a 3KD ultrafiltration membrane, dehydrate to 50g; add glucomannanase with a molecular weight greater than 5KD to 200U / g, enzymatically hydrolyze at 60℃ for 30 minutes, ultrafilter to cut off the extract with a molecular weight of less than 5KD, and dehydrate and concentrate to 50% solids using a reverse osmosis membrane to obtain 32g of yam extract;

[0137] 2. Take 100g of fresh Rehmannia glutinosa, crush and homogenize the tissue, remove insoluble matter to obtain fresh Rehmannia glutinosa juice; use an ultrafiltration membrane to cut off the juice with a molecular weight of less than 150nm, and dehydrate it to 20g using a 30nm ultrafiltration membrane to obtain concentrated Rehmannia glutinosa juice; use a 30nm permeate, stir and heat at 90℃ for 2.5h, use an ultrafiltration membrane to cut off the extract with a molecular weight of less than 5KD, concentrate it through a reverse osmosis membrane, and add the above total concentrated Rehmannia glutinosa juice to make up to 50% solids to obtain 30g of Rehmannia glutinosa extract;

[0138] 3. Take 5.5g of yam extract and 5.5g of rehmannia extract, add 5g of glycerin, 0.5g of 1,2-hexanediol and 0.5g of p-hydroxyacetophenone, and add water to 100g to obtain the composition.

[0139] Comparative Example 10:

[0140] The difference from Example 2 is that the Rehmannia glutinosa extract is replaced with Bletilla striata extract, specifically:

[0141] 1. Take 100g of fresh yam slices, steam at normal pressure for 30min, add 1200g of water and extract by gentle boiling for 60min; add 0.1g of amylase, enzymatically hydrolyze at 60℃ for 30min, filter until clear; dehydrate and cut off the extract with a molecular weight of 3KD or higher using a 3KD ultrafiltration membrane, dehydrate to 50g; add glucomannanase with a molecular weight greater than 5KD to 200U / g, enzymatically hydrolyze at 60℃ for 30min, ultrafilter to cut off the extract with a molecular weight of less than 5KD, and dehydrate and concentrate through a reverse osmosis membrane to a final volume of 50% solids to obtain 32g of yam extract;

[0142] 2. Take 100g of Bletilla striata and add 1000g of water, extract by gentle boiling for 60 minutes; after filtering the filtrate until clear, concentrate under reduced pressure to a solid content of 50% to obtain 38g of Bletilla striata extract;

[0143] 3. Take 12g of yam extract and 3g of Bletilla striata extract, add 5g of glycerin, 0.5g of 1,2-hexanediol and 0.5g of p-hydroxyacetophenone, and add water to 136g to obtain the composition.

[0144] Comparative Example 11:

[0145] The difference from Example 2 is that the yam extract is replaced with Bletilla striata extract, specifically:

[0146] 1. Take 100g of Bletilla striata and add 1000g of water, and extract by gentle boiling for 60 minutes; after filtering the filtrate until clear, concentrate it under reduced pressure until the solid content is 50% to obtain 38g of Bletilla striata extract;

[0147] 2. Take 100g of fresh Rehmannia glutinosa, crush and homogenize the tissue, remove insoluble matter to obtain fresh Rehmannia glutinosa juice; use an ultrafiltration membrane to cut off the juice with a molecular weight of less than 150nm, and dehydrate it to 20g using a 30nm ultrafiltration membrane to obtain concentrated Rehmannia glutinosa juice; use a 30nm permeate, stir and heat at 90℃ for 2.5h, use an ultrafiltration membrane to cut off the extract with a molecular weight of less than 5KD, concentrate it through a reverse osmosis membrane, and add the above total concentrated Rehmannia glutinosa juice to make up to 50% solids to obtain 30g of Rehmannia glutinosa extract;

[0148] 3. Take 12g of Bletilla striata extract and 3g of Rehmannia glutinosa extract, add 5g of glycerin, 0.5g of 1,2-hexanediol and 0.5g of p-hydroxyacetophenone, and add water to 136g to obtain the composition.

[0149] Application Examples 1-3: A cosmetic for barrier repair and its preparation method

[0150] The formula is as follows:

[0151]

[0152] Preparation method:

[0153] (1) 1,2-Pentanediol was dispersed in acrylate / C10-30 alkyl acrylate crosspolymer, then water was added, and the mixture was heated and stirred until homogeneous. The mixture was then placed in a water bath at 85°C to obtain phase A.

[0154] (2) Mix p-hydroxyacetophenone, arginine and water and heat to 40°C to obtain phase B; add phase B to phase A and stir at 150 rpm to cool down to below 50°C to obtain a mixture; add phase C to the mixture and stir to obtain the cosmetic product.

[0155] Application Comparative Example 1:

[0156] The formula is as follows:

[0157]

[0158] Preparation method:

[0159] (1) 1,2-Pentanediol was dispersed in acrylate / C10-30 alkyl acrylate crosspolymer, then water was added, and the mixture was heated and stirred until homogeneous. The mixture was then placed in a water bath at 85°C to obtain phase A.

[0160] (2) Mix p-hydroxyacetophenone, arginine and water and heat to 40°C to obtain phase B; add phase B to phase A and stir at 150 rpm to cool down to below 50°C to obtain a mixture.

[0161] Application of Comparative Example 2-12:

[0162] The formula is as follows:

[0163]

[0164] Preparation method:

[0165] (1) 1,2-Pentanediol was dispersed in acrylate / C10-30 alkyl acrylate crosspolymer, then water was added, and the mixture was heated and stirred until homogeneous. The mixture was then placed in a water bath at 85°C to obtain phase A.

[0166] (2) Mix p-hydroxyacetophenone, arginine and water and heat to 40°C to obtain phase B; add phase B to phase A and stir at 150 rpm to cool down to below 50°C to obtain a mixture; add phase C to the mixture and stir to obtain the cosmetic product.

[0167] Effect test:

[0168] 1. Stability testing:

[0169] The samples prepared in Examples 1-3 and Comparative Examples 1-11 were divided into four portions (each 20g sealed in a transparent PETE vial) and placed in a 4°C refrigerator, a 48°C incubator, at room temperature in the dark, and at room temperature under light conditions, respectively. The appearance, odor, and color of the samples were observed on day 7, day 14, day 21, and one month later. The test results are shown in Table 1 below.

[0170] Table 1

[0171]

[0172] According to the test results in Table 1 above:

[0173] Compared with Examples 1-3, the compositions prepared in Comparative Examples 4 and 6 were unstable. The composition prepared in Comparative Example 4 darkened in color when placed at 48°C, in the dark at room temperature, and under light at room temperature. This may be due to insufficient heating of the Rehmannia glutinosa, leading to browning of the components in the Rehmannia glutinosa extract, thus causing the color darkening. The composition prepared in Comparative Example 6 showed precipitation when placed at 4°C, 48°C, in the dark at room temperature, and under light at room temperature. This may be because residual glucomannanase in the yam extract precipitated over a long period, causing instability and precipitation.

[0174] 2. Product yield detection

[0175] The calculation formula is: Yield = (Mass of the obtained extract / Mass of the raw material) × 100%

[0176] The test results are shown in Table 2 below.

[0177] Table 2

[0178]

[0179] According to the data in Table 2 above, the yields of yam extracts in Comparative Examples 4 and 5 were significantly lower than those in Examples 1-3. The low yield in Comparative Example 4 may be due to the short extraction time and low temperature, resulting in a lower yield. The low yield in Comparative Example 5 may be due to the lack of enzymatic hydrolysis of the yam extract, leading to excessively large polysaccharide molecules, making filtration difficult and significantly reducing the yield. The significantly lower yields of Rehmannia glutinosa extracts in Comparative Examples 7 and 8 were also lower than those in Examples 1-3. This may be because the extract obtained in Comparative Example 7 did not retain extracts with molecular weights below 5KD, and the extract obtained in Comparative Example 8 did not retain the 30-150nm fraction, resulting in a significant decrease in the Rehmannia glutinosa extract yield.

[0180] 3. Human efficacy verification

[0181] 3.1 Experimental Methods

[0182] We expect to recruit no fewer than 30 healthy subjects aged 18-65, regardless of gender. Participants should have healthy, even-toned skin on the flexor side of their forearm, without scars or other conditions that may affect the test, and be able to use the product as required and complete the corresponding tests.

[0183] Day 0: Participants underwent screening after signing informed consent forms, and qualified participants were enrolled. Six to eight 3cm x 3cm areas were marked on the flexor side of the arm as test areas, and these areas were grouped using a random number table. The areas were equilibrated for 20 minutes at a temperature of 20-22℃ and humidity of 40-60%. The skin stratum corneum moisture content and transepidermal water loss (TEWL) of the test areas were measured. The skin was then peeled off with adhesive tape, six times per area. The corresponding test sample was then applied to each area; the model group did not receive any sample.

[0184] 1-2 days: Peel off the test area with tape every day, peeling off each area 6 times, and then use the test sample in each area.

[0185] 3-6 days: Use the corresponding test sample in the test area every day; do not apply any sample to the model group.

[0186] 7 days: After equilibration in the test environment for 20 minutes, the skin stratum corneum water content and transepidermal water loss (TEWL) of each pattern area were measured.

[0187] The test was conducted three times, with each test at least 28 days apart. If any adverse reaction occurred during the test, the test should be terminated immediately. The grouping of the three tests is shown in Table 3 below:

[0188] Table 3

[0189]

[0190] Note: Groups A, B, and C in the three tests are used as the basis for inter-test comparison. The comparison between the results of the three tests for each group should be ≤10%, otherwise the data will be excluded. The final result is presented as the average and standard deviation of the three tests.

[0191] Calculate the mean and standard deviation of each test indicator for all subjects at each time point. Calculate the change and rate of change relative to day 0. The formulas for calculating the change and rate of change are as follows:

[0192]

[0193]

[0194] In the formula, T0 is the average measurement value of the measured index on day 0;

[0195] Tn - The average measurement value of the measured index on day n;

[0196] n - Date of return visit.

[0197] The repair rate of the test sample is calculated using the following formula:

[0198]

[0199] In the formula, Rc represents the rate of change of skin physiological parameters in the model control area;

[0200] Rs - Rate of change of skin physiological parameters in the test sample area.

[0201] SPSS 22.0 software was used to perform statistical analysis on the data sets. Paired t-test was used to test the data between groups, and Dunnett's method was used to compare the sample groups with the model control. The significance level was set at α=0.05.

[0202] 3.2 Experimental Results

[0203] A total of 36 participants were recruited for this experiment, and 30 of them completed the test. The average age of the participants was 39.17 ± 13.31 years.

[0204] 3.3 Skin stratum corneum water content

[0205] The moisture content of the stratum corneum is one of the evaluation indicators for the repairing efficacy of cosmetics. A higher value indicates a higher moisture content in the stratum corneum. In a model where the skin barrier is slightly damaged after being peeled off with tape, if the moisture content of the stratum corneum in the area where the product was applied is significantly higher than in the area where the product was not applied, it indicates that the product has repairing, moisturizing, and hydrating effects. The test results are shown in Table 4 below.

[0206] Table 4

[0207]

[0208] Note: Compared with the blank group, p<0.05, p<0.01; compared with Example 2, ## p<0.01.

[0209] Testing showed that all samples containing the test samples (Application Examples 1-3 and Comparative Examples 2-12) significantly increased the stratum corneum moisture content of the skin, with significantly better results than Comparative Example 1 (blank group) which did not contain the test samples. Further analysis showed that the data measured on day 7 for Application Examples 1 and 3 were not significantly different from those for Application Example 2; in contrast, the stratum corneum moisture content of all comparative examples was significantly lower than that of Application Example 2.

[0210] 3.4 Transdermal water loss (TEWL)

[0211] Transepidermal water loss (TEWL) refers to the rate at which water diffuses from the skin through the stratum corneum as water vapor into the surrounding environment under undisturbed conditions. TEWL is a core indicator reflecting the function of the skin's stratum corneum barrier. When the stratum corneum structure is intact, water loss is low, resulting in a low TEWL value; when the barrier is damaged (e.g., due to dryness, inflammation, or trauma), water loss increases, and the TEWL value rises. In a model where the skin barrier is slightly damaged after being peeled off with tape, if the TEWL value of the skin in the product-treated area is significantly lower than that in the untreated area, it indicates that the product has repairing, moisturizing, and hydrating effects. The test results are shown in Table 5 below.

[0212] Table 5

[0213]

[0214] Compared to the base group, p<0.05, p<0.01; compared with Example 2, p<0.01.

[0215] Testing revealed that, compared to Comparative Example 1 (blank group), products containing the test samples (Application Examples 1-3, Comparative Examples 5-6) significantly reduced the increase in TEWL values ​​caused by tape peeling. Further analysis showed that the data measured on day 7 for Application Examples 1 and 3 were not significantly different from those for Application Example 2; in contrast, the TEWL values ​​of all Comparative Examples were significantly higher than those of Application Example 2.

[0216] In summary, the combination of yam extract and rehmannia extract obtained by the specific preparation method of this invention exhibits a synergistic effect, achieving new technical results and providing better repair and moisturizing effects. During the process, yam and rehmannia are extracted separately, and the extraction temperature, time, enzyme type, and molecular weight cutoff are controlled to achieve higher yields of both yam and rehmannia extracts, with yields exceeding 30%. Furthermore, the resulting composition exhibits better low-temperature, high-temperature, and light-induced stability.

[0217] The present invention has been described in detail above through specific embodiments, but the content thereon should not be construed as limiting the present invention. Those skilled in the art can make various equivalent substitutions, modifications, or improvements to the technical solutions and embodiments without departing from the spirit and scope of the present invention, and all such changes fall within the protection scope of the present invention, which is defined by the appended claims.

Claims

1. A composition for barrier repair, characterized in that: The composition comprises yam extract and rehmannia extract; the mass ratio of yam extract to rehmannia extract is 3-5:

1. The preparation method of the yam extract is as follows: Take fresh yam slices, steam them under normal pressure for 30 minutes, add 10-15 times the amount of water and extract by gentle boiling for 30-90 minutes, add amylase, and after full enzymatic hydrolysis, filter until clear, dehydrate and cut off the extract with a molecular weight of 3KD or higher through ultrafiltration membrane, dehydrate to 0.4-0.6 times the weight of the added fresh yam, add glucomannanase with a molecular weight greater than 5KD to 150-250U / g, enzymatically hydrolyze for 25-35 minutes, ultrafilter to cut off the extract with a molecular weight of less than 5KD, and dehydrate and concentrate through reverse osmosis membrane to a final volume of 50% solids to obtain yam extract; The preparation method of the Rehmannia glutinosa extract includes the following steps: Take fresh Rehmannia glutinosa, crush and homogenize the tissue, remove insoluble matter to obtain fresh Rehmannia glutinosa juice, use an ultrafiltration membrane to cut off the juice with a molecular weight of less than 150nm, use a 30nm ultrafiltration membrane to dehydrate to 15-25% of the fresh Rehmannia glutinosa to obtain concentrated Rehmannia glutinosa juice, use a 30nm permeate, stir and heat at 80-100℃ for 2-3 hours, use an ultrafiltration membrane to cut off the extract with a molecular weight of less than 5KD, concentrate through a reverse osmosis membrane, add the total amount of Rehmannia glutinosa juice to make up to 50% solids to obtain Rehmannia glutinosa extract.

2. The composition according to claim 1, characterized in that: The mass ratio of the yam extract to the rehmannia extract is 3:1, 4:1, or 5:

1.

3. The composition according to claim 1, characterized in that: The amount of amylase added is 0.08-0.12% of the weight of fresh yam.

4. The composition according to claim 1, characterized in that: The amylase is used for enzymatic hydrolysis at a temperature of 50-65℃.

5. The composition according to claim 1, characterized in that: The amylase is used for enzymatic hydrolysis for 20-40 minutes.

6. The composition according to claim 1, characterized in that: The preparation method of the yam extract includes the following steps: Take fresh yam slices, steam them under normal pressure for 30 minutes, add 12 times the amount of water and extract by gentle boiling for 60 minutes. Add 0.1% amylase by weight of fresh yam, and fully enzymatically hydrolyze at 60℃ for 30 minutes. Filter until clear, dehydrate and cut off the extract with a molecular weight of 3KD or higher using an ultrafiltration membrane, dehydrate to 0.5 times the weight of the added fresh yam, add glucomannanase with a molecular weight greater than 5KD to 200U / g, enzymatically hydrolyze at 60℃ for 30 minutes, ultrafilter to cut off the extract with a molecular weight of less than 5KD, and dehydrate and concentrate through a reverse osmosis membrane to a final volume of 50% solids to obtain yam extract.

7. The composition according to claim 1, characterized in that: The preparation method of the Rehmannia glutinosa extract includes the following steps: Fresh Rehmannia glutinosa was crushed, homogenized, and insoluble matter was removed to obtain fresh Rehmannia glutinosa juice. The juice with a molecular weight of less than 150 nm was removed by ultrafiltration membrane, and the water content of the fresh Rehmannia glutinosa was reduced to 20% by 30 nm ultrafiltration membrane to obtain concentrated Rehmannia glutinosa juice. The permeate with a molecular weight of 30 nm was stirred and heated at 90°C for 2.5 h, and then ultrafiltration membrane was used to remove the extract with a molecular weight of less than 5 KD. The extract was concentrated by reverse osmosis membrane, and the volume of Rehmannia glutinosa juice was added to make up to 50% solids to obtain Rehmannia glutinosa extract.

8. A method for preparing the composition according to any one of claims 1-7, characterized in that: Mix yam extract and rehmannia extract, then add glycerin, 1,2-hexanediol, p-hydroxyacetophenone and water, and mix well to obtain the final product.

9. The use of the composition according to any one of claims 1-7 in the preparation of cosmetics with barrier repair function, characterized in that: The cosmetics mentioned are lotions, serums, face masks, or sunscreens.

10. A cosmetic product with barrier repair function, characterized in that: The composition includes the composition and excipients according to any one of claims 1-7, wherein the excipients include 1,2-pentanediol, acrylate / C10-30 alkanol acrylate crosspolymers, and arginine.

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