Anti-aging composite nutritional composition and preparation method thereof

Abstract

The invention discloses an anti-aging compound nutritional composition as well as a preparation method and application thereof, and belongs to the technical field of foods. The composition is prepared from the following components in unit dose: 150 to 250 mg of nicotinamide ribose, 10 to 30 mg of pyrroloquinoline quinone disodium salt, 100 to 200 mg of quercetin phospholipid complex, 300 to 500 [mu] g of (6S)-5-calcium methyltetrahydrofolate, 30 to 80 [mu] g of methyl cobalamin, 5 to 15 mg of pyridoxine hydrochloride, 50 to 100 mg of radix astragali seu hedysari extract, 50 to 100 mg of fructus lycii extract, 50 to 100 mg of rhizoma polygonati extract and auxiliary materials. Through the synergistic effect of the nutrients and the traditional Chinese medicine extracts, NAD < + > improvement, mitochondrial protection, oxidation resistance and energy metabolism regulation are achieved, and the nutrient composition has novelty, safety and industrial practicability and can be used for preparing anti-aging nutritional supplements or health-care foods.

Description

[0001] With age, cellular NAD+ levels decline, mitochondrial function weakens, and oxidative stress accumulates, leading to a decline in age-related physiological functions. Current technologies utilize ingredients such as nicotinamide riboside (NR), pyrrolidone quinoline quinone (PQQ), quercetin, B vitamins, and active folic acid, which play roles in increasing NAD+ levels, protecting mitochondria, antioxidation, and regulating homocysteine ​​levels, respectively; however, the effects of a single ingredient are limited. Meanwhile, traditional Chinese medicines such as astragalus, wolfberry, and polygonatum have both traditional applications and modern research support in antioxidation, immune regulation, and fatigue improvement.

[0002] Currently available compositions are mostly combinations of nutrients or single herbal extracts, lacking synergistic anti-aging compositions that scientifically combine NR, PQQ, quercetin phospholipid complex, active folic acid, methyl B12, VB6 with extracts of Astragalus membranaceus, Lycium barbarum, and Polygonatum sibiricum. These compositions suffer from problems such as limited efficacy, homogenized formulations, and insufficient novelty. Therefore, developing a multi-target synergistic, safe, and clearly novel anti-aging complex nutritional composition is of significant value.

[0003] Purpose of the invention: To provide an anti-aging compound nutritional composition that is synergistic, safe, and meets the requirements of food / health food. Through the combination of nutrients and traditional Chinese medicine extracts, it achieves synergistic effects of NAD+ enhancement, mitochondrial protection, anti-oxidation, and energy metabolism regulation, while possessing patent novelty and inventiveness.

[0004] Technical solution: An anti-aging compound nutritional composition, wherein the unit dose contains: nicotinamide ribose, disodium pyrroloquinoline quinone, quercetin phospholipid complex, (6S)-5-methyltetrahydrofolate calcium, methylcobalamin, pyridoxine hydrochloride, astragalus extract, wolfberry extract, polygonatum extract and excipients.

[0005] Optimal formulation (unit dosage): Nicotinamide ribose 200 mg; 20 mg of disodium pyrroloquinoline quinone; Quercetin phospholipid complex 150 mg; (6S)-5-methyltetrahydrofolate calcium 400 μg; Methylcobalamin 50 μg; Pyridoxine hydrochloride 10 mg; Astragalus extract 80 mg; 80 mg of wolfberry extract; Polygonatum extract 60 mg; Excipients (microcrystalline cellulose, magnesium stearate, silicon dioxide) 20 mg.

[0006] Preparation method: Weighing → Premixing → Total mixing → Molding → Inner packaging → Outer packaging.

[0007] 1. Synergistic effect: NR enhances NAD+, PQQ protects mitochondria, quercetin provides antioxidant protection, B vitamins and active folic acid regulate metabolism, and traditional Chinese medicine extracts enhance antioxidant and immune regulation, resulting in multi-target synergy.

[0008] 2. High novelty: The combination of 6 nutrients and 3 extracts of Chinese medicinal herbs that are both food and medicine is not found in existing technology and has the potential for patent licensing.

[0009] 3. High safety: All ingredients are food-grade / new food raw materials / medicinal and edible homology, and the dosage is within the safe range, making it suitable for long-term consumption.

[0010] 4. Good compliance: It can be used for filing / registration of nutritional supplements or health foods, and complies with domestic regulations.

[0011] Example 1 (hard capsule, approximately 620 mg / capsule) Components (per capsule): Nicotinamide ribose 200 mg; 20 mg of disodium pyrroloquinoline quinone; Quercetin phospholipid complex 150 mg; (6S)-5-methyltetrahydrofolate calcium 400 μg; Methylcobalamin 50 μg; Pyridoxine hydrochloride 10 mg; Astragalus extract 80 mg; 80 mg of wolfberry extract; Polygonatum extract 60 mg; Microcrystalline cellulose 15 mg; Magnesium stearate 3 mg; 2 mg of silicon dioxide.

[0012] Preparation steps: 1. Accurately weigh each component; 2. Premix the active ingredients for 8 minutes; 3. Add the excipients and mix for 18 minutes; 4. Filling of #0 capsules; 5. Aluminum-plastic blister packaging, inspection and warehousing.

[0013] Example 2 (tablets, approximately 620 mg / tablet): The mixture from Example 1 was dry-granulated and then compressed into tablets with a hardness of 4–8 kgf. The rest of the process was the same as in Example 1.

[0014] Efficacy verification: In vitro antioxidant assays (DPPH, ABTS free radical scavenging rate) and cellular mitochondrial membrane potential detection showed that the composition was significantly more effective than the single-component group, indicating a clear synergistic effect.

[0015] Comparative Example 1: Contains no Chinese herbal extracts, otherwise the same as Example 1.

[0016] Comparative Example 2: Excluding NR and PQQ, otherwise the same as Example 1.

[0017] Results: Example 1 of the present invention is superior to Comparative Examples 1 and 2 in terms of antioxidant and mitochondrial protection indicators, proving the necessity of combination and ratio.

[0018] Safety statement: All components comply with national food safety standards, announcements of new food raw materials and the requirements of the list of food and medicine homology. The dosage is within the daily allowable intake range, with no obvious toxic side effects, and is suitable for long-term consumption by adults.

[0019] Industrial applicability: This composition can be produced using conventional food / health food equipment. The process is stable and the cost is controllable, making it suitable for industrial production and market promotion.

Claims

1. An anti-aging compound nutritional composition, characterized in that, It contains the following components per unit dose: Nicotinamide ribose 150–250 mg; Disodium pyrroloquinoline quinone 10–30 mg; Quercetin phospholipid complex 100–200 mg; (6S)-5-methyltetrahydrofolate calcium 300–500 μg; Methylcobalamin 30–80 μg; Pyridoxine hydrochloride 5–15 mg; Astragalus extract 50–100 mg; Goji berry extract 50–100 mg; Polygonatum extract 50–100 mg; Excipients 10–50 mg.

2. The composition according to claim 1, characterized in that, per unit dose, including: Nicotinamide ribose 200 mg; 20 mg of disodium pyrroloquinoline quinone; Quercetin phospholipid complex 150 mg; (6S)-5-methyltetrahydrofolate calcium 400 μg; Methylcobalamin 50 μg; Pyridoxine hydrochloride 10 mg; Astragalus extract 80 mg; 80 mg of wolfberry extract; Polygonatum extract 60 mg; The total amount of microcrystalline cellulose, magnesium stearate, and silicon dioxide is 20 mg.

3. The composition according to claim 1, characterized in that, The mass ratio of quercetin to phospholipid in the quercetin-phospholipid complex is 1:1 to 2:

1.

4. The composition according to claim 1, characterized in that, The Astragalus extract, Lycium barbarum extract, and Polygonatum sibiricum extract are extracted with water or alcohol, and the content of their active ingredients meets food-grade standards.

5. The composition according to claim 1, characterized in that, Dosage forms include hard capsules, tablets, or granules.

6. A method for preparing the anti-aging compound nutritional composition according to any one of claims 1-5, characterized in that, Includes the following steps:

1. Accurately weigh each active ingredient and excipient according to the formula ratio; 2. Premix the active ingredients for 5–10 minutes; 3. Add the excipients and mix for 15–20 minutes to obtain a homogeneous mixture; 4. After filling or pressing, it is encapsulated inside and outside to obtain the product.

7. The composition of any one of claims 1–5 may be used for non-therapeutic purposes in the preparation of nutritional supplements or health foods for antioxidant, mitochondrial protection, and improvement of energy metabolism.