Tumor targeted therapy system combining energy field with embolism microspheres

Abstract

The invention provides a tumor targeted therapy system combining an energy field with embolism microspheres, which is applied to the field of tumor therapy instruments, and is characterized in that an energy enrichment material for targeting and enriching an external electric field or ultrasonic energy is loaded inside or on the surface of the embolism microspheres; therefore, TACE (Trans Arterial Chemoembolism) and energy release unit treatment are synergistically matched, on one hand, the embolism microspheres are implanted into a tumor blood supply artery in a minimally invasive catheter implantation mode in the early stage of the operation so as to block blood flow or nutrition supply of a tumor part; on the other hand, accurate focusing is carried out through an electric field / ultrasonic energy generator in the postoperative stage, normal cells are not damaged, and the microenvironment around the tumor is improved; embolism treatment and energy ablation treatment are combined for the first time, the safety and the treatment effect in the treatment process are further improved, and a new way for solid tumor treatment is opened up.

Description

Technical Field

[0001] This invention relates to the field of tumor treatment devices, particularly solid tumor treatment devices, and specifically to a tumor targeted therapy system that combines an energy field with embolized microspheres. Background Technology

[0002] According to data released by the International Agency for Research on Cancer (IARC) of the World Health Organization, the global cancer burden continues to rise. For example, in 2020, there were 19.29 million new cancer cases and 9.96 million cancer deaths worldwide. It is projected that by 2040, the number of new cancer cases globally will reach nearly 30 million, and the cancer burden will increase by 50% compared to 2020. Solid tumors account for a significant proportion of these new cancer cases. For instance, in 2020, the number of new cases of breast cancer, lung cancer, colorectal cancer, stomach cancer, and liver cancer were 2.26 million, 2.2 million, 1.93 million, 1.09 million, and 910,000 respectively, further reflecting the severity of the cancer burden caused by solid tumors.

[0003] In recent years, significant progress has been made globally in the research and treatment of solid tumors. Transarterial chemoembolization (TACE) is a minimally invasive technique commonly used in the treatment of malignant tumors, particularly liver cancer. It uses catheter technology to directly deliver chemotherapy drugs and embolic agents into the blood supply arteries of the liver tumor, achieving high local concentrations and blocking the tumor's blood supply. This not only increases the effective concentration of chemotherapy drugs in the tumor area and reduces the impact on normal tissues, but also inhibits tumor growth by blocking blood flow to the tumor through the embolic agent. Tumor-treating fields (TTF) is another commonly used treatment option. It uses a low-intensity, mid-frequency alternating electric field to act on the microtubules of proliferating cancer cells, inhibiting tumor growth and causing the death of cancer cells affected by the electric field by interfering with cancer cell mitosis. It is an external, non-invasive treatment, easy to wear, with few side effects for patients, improving quality of life, increasing cell membrane and blood-brain barrier penetration, and when used concurrently with chemotherapy drugs, it can improve the absorption rate of chemotherapy drugs; when used in combination with immunotherapies, it significantly enhances sensitization.

[0004] However, both of the above treatment options have certain drawbacks. For transarterial chemoembolization (TACE), it often requires advanced imaging equipment to guide the delivery of microspheres, placing high demands on the surgeon's experience and the equipment, thus increasing the cost. Secondly, it lacks energy focusing effect, significantly reducing the effectiveness of subsequent treatments. As for tumor-treating fields (TTF), its focusing is insufficient, frequently causing electric field mis-penetration, focusing and damaging surrounding normal tissue, resulting in certain side effects. Therefore, based on the aforementioned shortcomings of existing technologies, there is an urgent need for a novel embolization treatment system to overcome these deficiencies. Summary of the Invention

[0005] In view of the shortcomings of the prior art, the present invention aims to provide a tumor targeted therapy system that combines energy field with embolization microspheres. This system synergistically combines embolization microspheres with energy release therapy, thereby improving the energy aggregation effect of embolization microspheres and enhancing their imaging effect, thus significantly improving the therapeutic effect and reducing the side effects of treatment.

[0006] This invention provides a tumor-targeted therapy system combining energy field with embolized microspheres, comprising: One or more embolization microspheres, wherein the embolization microspheres are loaded with energy-enriching materials and / or energy-enriching structures inside or on the surface of the embolization microspheres; An energy generator, comprising a host device and at least one energy release unit, wherein the energy release unit is electrically connected to the host device, receives an energy signal from the host device, and directs the energy signal to a target area of ​​the patient; The energy-enriching material targets and enriches the energy signal into the blockage area of ​​the embolization microspheres, thereby ablating the diseased tissue in the blockage area through the energy effect.

[0007] Preferably, the energy enrichment material is a ferroelectric material, which includes at least one of ferroelectric ceramics, multiferroic materials, and ferroelectric thin films.

[0008] Preferably, the energy enrichment structure includes at least one of an acoustic lens structure and a concave reflector structure.

[0009] Preferably, the embolization microspheres are at least one of carbon microspheres, glass microspheres, polyvinyl alcohol, polyacrylic acid, albumin, gelatin, starch, polylactic acid, chitosan, sodium alginate, and ethyl cellulose.

[0010] Preferably, the embolized microspheres are loaded with an antitumor drug.

[0011] Preferably, the antitumor drug includes one or more of the following: chemotherapy drugs, targeted therapy drugs, immunotherapy drugs, endocrine therapy drugs, and traditional Chinese medicine.

[0012] Furthermore, the microsphere embolization treatment system also includes an embolization microsphere catheter delivery device.

[0013] Preferably, the energy generator is an electric field generator, the energy release unit is an electrode sheet, and the energy signal is an electric field signal with a specific waveform, a specific frequency, and a specific electric field strength.

[0014] Preferably, the specific waveform is selected from at least one of sine wave and square wave.

[0015] Preferably, the electric field signal is generated by an inverter or signal amplifier within the host device.

[0016] Preferably, the electrode sheet is at least one of a metal substrate electrode and a ceramic electrode.

[0017] Furthermore, the microsphere embolization treatment system also includes a wearing fabric, to which at least one electrode pad is detachably connected.

[0018] Preferably, the energy generator is an ultrasonic therapy device, the energy release unit is an ultrasonic therapy head, and the energy signal is an ultrasonic signal with a specific frequency, specific sound intensity, and specific duty cycle.

[0019] Compared with the prior art, the beneficial effects that at least one technical solution adopted in the embodiments of this specification can achieve include at least: First, this invention combines transarterial chemoembolization (TACE) with energy release unit therapy. On the one hand, in the early stage of the procedure, embolization microspheres are implanted into the tumor-supplying artery via a minimally invasive catheter to block blood flow or nutrient supply to the tumor site. On the other hand, in the later stage of the procedure, non-invasive treatment is performed using energy generators such as electric fields / ultrasound, which does not damage normal cells and provides precise treatment. This invention is the first to combine embolization therapy with energy ablation therapy, opening up a new avenue for the treatment of solid tumors.

[0020] Second, the present invention attaches an energy-enriching material and / or an energy-enriching structure to the interior or surface of the embolization microsphere. The energy-enriching material is preferably a ferroelectric material, including at least one of ferroelectric ceramics, multiferroic materials, and ferroelectric thin films. The energy-enriching structure includes at least one of an acoustic lens structure and a concave mirror structure. This energy-enriching material and / or energy-enriching structure can target and enrich external energy such as electric fields or ultrasound, improving the focusing of external energy and preventing energy from focusing on non-target areas. This generates electrical, thermal, and / or mechanical effects around the target location of the embolization microsphere, further improving the safety and efficacy of the treatment process. Simultaneously, the energy-enriching material is preferably radiopaque iron, thereby improving visibility during the embolization procedure.

[0021] Third, the energy generator of the present invention is preferably an electric field generator, and the electric field signal emitted is preferably a square wave. According to experimental results, under the same field strength, the square wave has a greater tumor inhibition rate than the sine wave. In the electric field generator of the present invention, an inverter is more preferably used as the main voltage source component. Compared with the low efficiency, high loss (around 18W), high noise and low battery life (2-3 hours) of traditional signal amplifiers, the inverter solution of the present invention has high efficiency and low loss as low as around 5W. It does not require a heat sink and fan, further reducing noise. In addition, the battery life is also greatly extended (8-10 hours). Furthermore, the electric field generator of the present invention more preferably uses a metal substrate electrode. Compared with the traditional ceramic electrode, which has disadvantages such as high loss, serious heat generation, skin burns, and high temperature alarm shutdown, the metal substrate electrode of the present invention has low loss and low heat generation, which can effectively protect the skin and avoid skin damage caused by heat generation. Moreover, the high temperature alarm can be basically eliminated.

[0022] Fourth, the embolization microspheres of the present invention can also carry anti-tumor drugs such as chemotherapy drugs, targeted therapy drugs, immunotherapy drugs, endocrine therapy drugs, and traditional Chinese medicine, thereby further improving the anti-tumor efficacy of the microsphere embolization therapy system.

[0023] Fifth, the microsphere embolization treatment system of the present invention also includes a wearing fabric to facilitate electrode positioning and wearing; in addition, the electrodes are detachably connected to the wearing fabric to facilitate cleaning of the wearing fabric. Attached Figure Description

[0024] To more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort. Figure 1 This is a schematic diagram of the structural principle of the first embodiment of the tumor targeted therapy system combining energy field with embolized microspheres of the present invention. Figure 2 This is a schematic diagram of the embolization microsphere structure in the first embodiment of the present invention; Figure 3 This is tumor suppression data from cell experiments under different waveforms according to the first embodiment of the present invention; Figure 4 This is tumor suppression data from a cell experiment using TTF combined with a PD-1 inhibitor, as described in the first embodiment of this invention. Figure 5 This is a schematic diagram of the structural principle of the second embodiment of the tumor targeted therapy system combining energy field with embolized microspheres of the present invention.

[0025] Explanation of reference numerals in the attached figures Detailed Implementation The embodiments of the present invention will now be described in detail with reference to the accompanying drawings.

[0026] The following specific examples illustrate the implementation of the present invention. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of them. The present invention can also be implemented or applied through other different specific embodiments, and the details in this specification can also be modified or changed based on different viewpoints and applications without departing from the spirit of the present invention. It should be noted that, in the absence of conflict, the following embodiments and features in the embodiments can be combined with each other. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.

[0027] It should be noted that various aspects of embodiments within the scope of the appended claims are described below. It will be apparent that the aspects described herein can be embodied in a wide variety of forms, and any particular structure and / or function described herein is merely illustrative. Based on this invention, those skilled in the art will understand that one aspect described herein can be implemented independently of any other aspect, and two or more of these aspects can be combined in various ways. For example, any number and aspects set forth herein can be used to implement the device and / or practice the method. Additionally, this device and / or method can be implemented using structures and / or functionalities other than one or more of the aspects set forth herein.

[0028] It should also be noted that the illustrations provided in the following embodiments are only schematic representations of the basic concept of the present invention. The drawings only show the components related to the present invention and are not drawn according to the actual number, shape and size of the components in the actual implementation. In the actual implementation, the form, quantity and proportion of each component can be arbitrarily changed, and the layout of the components may also be more complex.

[0029] Additionally, specific details are provided in the following description to facilitate a thorough understanding of the examples. However, those skilled in the art will understand that practice can be carried out without these specific details.

[0030] Furthermore, descriptions of orientation in this specification, such as up, down, left, right, front, back, inside, outside, longitudinal, transverse, vertical, and horizontal, are based on the orientations or positional relationships shown in the accompanying drawings. They are only for the convenience of describing the invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the invention. In addition, in this specification, proximal and distal ends are relative to the direction of the control base in the dual-source assisted endoscopic surgery artificial intelligence platform. The end closer to the control base is the proximal end, and the end farther from the control base is the distal end.

[0031] Furthermore, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances, and they should not be construed as limiting the invention.

[0032] Example 1: Figure 1 The diagram shown is a schematic representation of the structure and principle of the first embodiment of the tumor-targeted therapy system combining energy field with embolization microspheres of the present invention. The tumor-targeted therapy system 1 combining energy field with embolization microspheres includes at least one or more embolization microspheres 11 and an electric field generator 12. The embolization microspheres 11 are preferably at least one of carbon microspheres, glass microspheres, polyvinyl alcohol, polyacrylic acid, albumin, gelatin, starch, polylactic acid, chitosan, sodium alginate, and ethyl cellulose. Those skilled in the art can select embolization microspheres made of suitable materials according to actual needs, and the specific materials should not be construed as limiting the scope of protection of the independent claims.

[0033] Furthermore, such as Figure 2As shown, the embolized microsphere 11 has an electric field enrichment material 111 attached inside or on its surface. Those skilled in the art can select a suitable electric field enrichment material 111 and any conventional coupling method in the prior art to attach the embolized microsphere 11 to the electric field enrichment material 111 according to the specific material of the embolized microsphere 11. In a preferred embodiment, the electric field enrichment material 111 is preferably a ferroelectric material, which includes at least one of ferroelectric ceramics, multiferroic materials, and ferroelectric thin films. However, those skilled in the art should understand that any material capable of enriching electric field energy should be included within the spirit of this invention, and ferroelectric materials and their specific types should not be construed as limiting the scope of the claims. In all electric field enrichment materials 111, the iron element in the ferroelectric material includes ferrous iron (Fe2+) and / or ferric iron (Fe3+). When the embolization microspheres 11 are negatively charged, ferrous iron (Fe2+) and / or ferric iron (Fe3+) can connect to the negatively charged embolization microspheres 11 through electrostatic interaction, targeting and enriching the external electric field, improving the focusing of external energy, and preventing energy from focusing on non-target areas. This generates electrical and thermal effects around the aggregation site of the embolization microspheres 11, further improving the safety and therapeutic effect during the treatment process. At the same time, iron has good imaging properties, which can further improve the visibility during the embolization procedure, avoid the use of additional contrast agents, and further reduce side effects during the procedure.

[0034] In this embodiment, the electric field generator 12 of the tumor-targeted therapy system 1 combining energy field with embolized microspheres includes an electric field generator main unit 121, at least one electrode 122, and an electric field power supply module 124. The electric field power supply module 124 is electrically connected to the main unit 121 and supplies power to the main unit 121. The electrode 122 is electrically connected to the electric field generator main unit 121, receives electric field signals from the electric field generator main unit 121, and directs the electric field signals to the patient's target area. Preferably, the number of electrode 122 is two or more, more preferably four, six, or eight. The plurality of electrode 122 are preferably detachably connected to the electric field generator main unit 121 via an electrode junction box 123, thereby facilitating the selection of the corresponding number of electrode 122 according to actual use needs, without having to keep all electrode 122 in working condition, thus avoiding unnecessary energy consumption.

[0035] In this embodiment, the electrode sheet 122 is at least one of a metal substrate electrode and a ceramic electrode, and more preferably a metal substrate electrode. Compared with traditional ceramic electrodes, which have disadvantages such as high loss, severe heat generation, potential skin burns, and high-temperature alarm shutdowns, metal substrate electrodes have low loss and low heat generation, which can more effectively protect the skin and avoid skin damage caused by heat generation, and the high-temperature alarm can be basically eliminated. However, those skilled in the art should understand that the electrode material is only a preferred example, and those skilled in the art can choose different electrode materials according to the actual situation. The material itself should not be construed as limiting the scope of protection of the independent claim.

[0036] Preferably, in this embodiment, the electric field signal generated by the electric field generator host device 121 and introduced into the solid tumor lesion through the electrode plate 122 is an electric field signal with a specific waveform, a specific frequency, and a specific electric field strength. The specific waveform is selected as a sine wave or a square wave, the specific electric field frequency is preferably from 100kHz to 300kHz, and the specific electric field strength is preferably from 1 to 3V / cm; furthermore, Figure 3 The data shown illustrates tumor inhibition data from cell experiments using different waveforms of TTF in the first embodiment of this invention. The data reveals that in the control group, tumor cell counts reached 21.6, 31.2, and 59.0 after 24h, 48h, and 72h, respectively, with a gradually increasing growth rate. In the sine wave experimental group, tumor cell counts reached 19.2, 19.9, and 26.3 after 24h, 48h, and 72h, respectively, with a significant inhibition of tumor cell growth rate after 48h. In contrast, in the square wave experimental group, tumor cell counts reached 18.6, 17.8, and 14.6 after 24h, 48h, and 72h, respectively, with a significant inhibition of tumor cell growth rate and even negative growth after 48h. Therefore, both sine and square waves significantly inhibit tumor cell growth rate, but the square wave exhibits a more pronounced inhibitory effect. Thus, the specific waveforms described in this embodiment are selected from at least one of sine and square waves, with a square wave being more preferred.

[0037] In addition, the sinusoidal and / or square wave electric field signals in this embodiment are preferably generated by an inverter or signal amplifier in the host device, and more preferably by an inverter. Compared with the low efficiency, high loss (around 18W), high noise and low battery life (2-3 hours) of traditional signal amplifiers, the inverter solution of this invention is highly efficient, with a loss as low as around 5W, and does not require a heat sink and fan, further reducing noise. In addition, the battery life is also greatly extended (8-10 hours).

[0038] Preferably, in order to improve the anti-tumor treatment effect, the embolization microspheres 11 of this embodiment may be further loaded with anti-tumor drugs. The anti-tumor drugs may be selected from one or more of chemotherapy drugs, targeted therapy drugs, immunotherapy drugs, endocrine therapy drugs, and traditional Chinese medicines, and the anti-tumor drugs may be coupled to the embolization microspheres 11 through any conventional connection method in the prior art. Figure 4 The data shown represents the tumor inhibition data of the cell experiment using TTF combined with a PD-1 inhibitor according to the first embodiment of the present invention. As can be seen from the data, the tumor inhibition rates of the PD-1 inhibitor control group (PD-1 inhibitor concentration 30 μg / mL) reached 0.11, 0.17, and 0.26 after 24 h, 48 h, and 72 h, respectively. In contrast, the tumor inhibition rates of the TTF combined with the PD-1 inhibitor experimental group (TTF 150 kHz 35V square wave, PD-1 inhibitor concentration 30 μg / mL) reached 0.17, 0.26, and 0.39 after 24 h, 48 h, and 72 h, respectively. Therefore, the TTF+PD-1 inhibitor regimen in this embodiment shows a 14% better inhibitory effect on tumor cells compared to PD-1 inhibitor alone, and can further improve the tumor inhibition effect.

[0039] Furthermore, the tumor-targeted therapy system 1 of this embodiment, which combines energy field with embolized microspheres, may also include a necessary embolized microsphere catheter delivery device, thereby facilitating the delivery of the embolized microspheres 11 to the arterial vascular region where the solid tumor is located via minimally invasive surgery. The embolized microsphere catheter delivery device can be any conventional delivery device in the prior art, and it is not a core feature of this invention, so it is not illustrated. However, those skilled in the art should understand that the embolized microsphere catheter delivery device can be presented as one of the components in the final treatment system.

[0040] Furthermore, the tumor-targeted therapy system 1 of the energy field combined with embolized microspheres in this embodiment may further include a wearable fabric, wherein at least one electrode pad 122 is detachably connected to the wearable fabric. The wearable fabric includes, but is not limited to, vests, bras, underwear, waist supports, and any other conventional fabric type in the art. The detachable connection method includes, but is not limited to, Velcro, zippers, magnetic closures, and fastenings. More preferably, the electrode pad 122 is detachably connected to the inner surface of the wearable fabric. By configuring an additional wearable fabric in the tumor-targeted therapy system 1 of the energy field combined with embolized microspheres, the positioning and wearing of the electrode pad 122 are facilitated. In addition, the detachable connection of the electrode pad 122 to the wearable fabric facilitates the cleaning and disinfection of the wearable fabric, which is especially convenient for hospital use.

[0041] The treatment process of the tumor-targeted therapy system 1, which combines energy field with embolized microspheres in this embodiment 1, generally includes the following steps: S1. With the assistance of imaging equipment, physicians place the embolization microsphere catheter delivery device into the blood supply artery of the solid tumor through minimally invasive surgery; S2. The embolization microspheres 11 described in the above preferred embodiments are introduced from the blood supply artery of the solid tumor into the branch artery of the solid tumor through the embolization microsphere catheter delivery device, thereby blocking the blood supply to the solid tumor site. The embolization microspheres 11 are loaded with electric field enrichment material 111 inside or on the surface. S3. At least one electrode pad 122 is applied to the treatment area, and the electric field generator is activated. A sinusoidal or square wave electric field signal with a frequency of 100kHz to 300kHz and a field strength of 1 to 3V / cm is introduced through the electrode pad 122. Under the enrichment effect of the electric field enrichment material 111, the electric field signal generates electrical and thermal effects at the target site of the solid tumor, thereby improving the tumor microenvironment. S4. Treatment time is more than 18 hours per day, lasting for several weeks to several months.

[0042] Example 2: Figure 5 The diagram shown is a schematic diagram of the structural principle of the second embodiment of the tumor targeted therapy system of energy field combined with embolized microspheres of the present invention. Compared with the preferred embodiments in Embodiment 1, the main difference is that the energy generator in this embodiment is replaced by an ultrasound therapy device 13 instead of the electric field generator 12 in Embodiment 1. That is, the tumor targeted therapy system 1 of energy field combined with embolized microspheres includes at least one or more embolized microspheres 11 and an ultrasound therapy device 13. The embolized microspheres 11 are preferably at least one of carbon microspheres, glass microspheres, polyvinyl alcohol, polyacrylic acid, albumin, gelatin, starch, polylactic acid, chitosan, sodium alginate, and ethyl cellulose. Those skilled in the art can select embolized microspheres of suitable materials according to actual needs. The specific material should not be construed as limiting the scope of protection of the independent claims.

[0043] Furthermore, an ultrasonic enrichment structure 112 is attached to the interior or surface of the embolized microspheres 11. Those skilled in the art can select a suitable ultrasonic enrichment structure 112 and any conventional coupling method in the prior art to attach the embolized microspheres 11 to the ultrasonic enrichment structure 112 based on the specific material of the embolized microspheres 11. In a preferred embodiment, the ultrasonic enrichment structure 112 can be at least one of an acoustic lens structure or a concave mirror structure. However, those skilled in the art should understand that any structure or element that can enrich ultrasonic energy should be included within the inventive spirit of this invention. The acoustic lens structure and the concave mirror structure target and enrich the external ultrasonic energy, improving the focusing of external energy and preventing energy from focusing on non-target areas. This generates mechanical and thermal effects around the aggregation site of the embolized microspheres 11, further improving the safety and therapeutic effect during treatment. Of course, those skilled in the art can simultaneously connect the ultrasonic enrichment structure 112 and the electric field enrichment material 111 to the interior or surface of the embolized microspheres 11 according to actual needs, to simultaneously meet the requirements of electric field therapy and ultrasonic therapy.

[0044] In this embodiment, the ultrasound therapy device 13 of the tumor-targeted therapy system 1 combining energy field and embolized microspheres includes an ultrasound therapy main unit 131 and at least one ultrasound therapy head 132. The ultrasound therapy head 132 is electrically connected to the ultrasound therapy main unit 131, receives high-frequency electrical signals from the ultrasound therapy main unit 131, and converts the high-frequency electrical signals into therapeutic ultrasound waves through an ultrasound transducer 1321 disposed inside the therapy head 132 and introduces them into the patient's target area. The ultrasound therapy main unit 131 includes at least an ultrasound generator 1311, an ultrasound power supply module 1312, and a necessary control module 1313. The ultrasound power supply module 1312 is electrically connected to the ultrasound generator 1311 and supplies power to the ultrasound generator 1311. The ultrasound generator 1311 converts AC power (such as 115V or 240V) into high-frequency electrical signals with a frequency close to 20kHz through voltage conversion and frequency adjustment. These high-frequency electrical signals are then converted into mechanical energy in the form of ultrasonic vibrations by the ultrasound transducer 1321 through the piezoelectric effect. During this process, the control module 1313 adjusts the output parameters of the ultrasonic generator (such as frequency, power, time, etc.) to control the ultrasonic characteristics generated by the ultrasonic transducer, thereby meeting different application requirements. Preferably, in this embodiment, the therapeutic ultrasonic waves generated by the ultrasonic transducer have a preferred frequency of 0.2~5MHz, a preferred sound intensity ≥12000W / cm², and a preferred duty cycle of 20%~80%. Furthermore, the ultrasonic therapy head 13 can also be equipped with auxiliary components such as a foot switch, a cooling water tank, and a control panel as needed. Since these are well-known technologies in the art, they will not be described in detail here. Preferably, in this embodiment, the number of ultrasonic therapy heads 132 is at least one, preferably two or more, more preferably four, six, or eight.

[0045] Preferably, in order to improve the anti-tumor treatment effect, the embolization microspheres 11 of this embodiment can also be further loaded with anti-tumor drugs. The anti-tumor drugs can be selected from one or more of chemotherapy drugs, targeted therapy drugs, immunotherapy drugs, endocrine therapy drugs, and traditional Chinese medicines, and the anti-tumor drugs can be coupled to the embolization microspheres 11 through any conventional connection method in the prior art.

[0046] Furthermore, the tumor-targeted therapy system 1 of this embodiment, which combines energy field with embolized microspheres, may also include a necessary embolized microsphere catheter delivery device, thereby facilitating the delivery of the embolized microspheres 11 to the arterial vascular region where the solid tumor is located via minimally invasive surgery. The embolized microsphere catheter delivery device can be any conventional delivery device in the prior art, and it is not a core feature of this invention, so it is not illustrated. However, those skilled in the art should understand that the embolized microsphere catheter delivery device can be presented as one of the components in the final treatment system.

[0047] The treatment process of the tumor-targeted therapy system 1, which combines energy field with embolized microspheres in this embodiment 2, generally includes the following steps: S1. With the assistance of imaging equipment, physicians place the embolization microsphere catheter delivery device into the blood supply artery of the solid tumor through minimally invasive surgery; S2. The embolization microspheres 11 described in the above preferred embodiments are introduced from the blood supply artery of the solid tumor into the branch artery of the solid tumor through the embolization microsphere catheter delivery device, thereby blocking the blood supply to the solid tumor site. The embolization microspheres 11 are equipped with an ultrasound enrichment structure 112 inside or on the surface of the embolization microspheres 11. S3. Apply at least one ultrasound treatment head 132 to the treatment area, activate the main unit of the ultrasound therapy device, and introduce a therapeutic ultrasound signal with a frequency of 0.2~5MHz, preferably a sound intensity ≥12000W / cm², and preferably a duty cycle of 20%~80% through the electro-ultrasound treatment head 132. The therapeutic ultrasound signal generates mechanical and thermal effects at the target site of the solid tumor under the enrichment effect of the ultrasound enrichment structure 112, thereby improving the tumor microenvironment. S4. Repeat step S3 every 1-2 months.

[0048] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in the present invention should be included within the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be determined by the scope of the claims.

Claims

1. A tumor-targeted therapy system combining energy field with embolized microspheres, characterized in that, include: One or more embolization microspheres, wherein the embolization microspheres are loaded with energy-enriching materials and / or energy-enriching structures inside or on the surface of the embolization microspheres; An energy generator, comprising a host device and at least one energy release unit, wherein the energy release unit is electrically connected to the host device, receives an energy signal from the host device, and directs the energy signal to a target area of ​​the patient; The energy-enriching material targets and enriches the energy signal into the blockage area of ​​the embolization microspheres, thereby ablating the diseased tissue in the blockage area through the energy effect.

2. The tumor-targeted therapy system combining energy field with embolized microspheres according to claim 1, characterized in that, The energy enrichment material is a ferroelectric material, which includes at least one of ferroelectric ceramics, multiferroic materials, and ferroelectric thin films.

3. The tumor-targeted therapy system combining energy field with embolized microspheres according to claim 1, characterized in that, The energy enrichment structure includes at least one of an acoustic lens structure and a concave mirror structure.

4. The tumor-targeted therapy system combining energy field with embolized microspheres according to claim 1, characterized in that, The embolization microspheres are at least one of the following: carbon microspheres, glass microspheres, polyvinyl alcohol, polyacrylic acid, albumin, gelatin, starch, polylactic acid, chitosan, sodium alginate, and ethyl cellulose.

5. The tumor-targeted therapy system combining energy field with embolized microspheres according to claim 1, characterized in that, The embolized microspheres are loaded with antitumor drugs.

6. The tumor-targeted therapy system combining energy field with embolized microspheres according to claim 5, characterized in that, The anti-tumor drugs include one or more of the following: chemotherapy drugs, targeted therapy drugs, immunotherapy drugs, endocrine therapy drugs, and traditional Chinese medicine.

7. The tumor-targeted therapy system combining energy field with embolized microspheres according to claim 1, characterized in that, The microsphere embolization treatment system also includes an embolization microsphere catheter delivery device.

8. The tumor-targeted therapy system combining energy field with embolized microspheres according to any one of claims 1-7, characterized in that, The energy generator is an electric field generator, the energy release unit is an electrode sheet, and the energy signal is an electric field signal with a specific waveform, a specific frequency, and a specific electric field strength.

9. The tumor-targeted therapy system combining energy field with embolized microspheres according to claim 8, characterized in that, The specific waveform is selected from at least one of sine wave and square wave.

10. The tumor-targeted therapy system combining energy field with embolized microspheres according to claim 8, characterized in that, The electric field signal is generated by an inverter or signal amplifier within the host device.

11. The tumor-targeted therapy system based on energy field combined with embolized microspheres according to claim 8, characterized in that, The electrode sheet is at least one of a metal substrate electrode and a ceramic electrode.

12. The tumor-targeted therapy system combining energy field with embolized microspheres according to claim 8, characterized in that, The microsphere embolization treatment system also includes a wearable fabric, to which at least one electrode pad is detachably connected.

13. The tumor-targeted therapy system combining energy field with embolic microspheres according to any one of claims 1-7, characterized in that, The energy generator is an ultrasonic therapy device, the energy release unit is an ultrasonic therapy head, and the energy signal is an ultrasonic signal with a specific frequency, specific sound intensity, and specific duty cycle.

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