Medical microfluidic patch

Abstract

The application provides a medical micro-flow channel patch, which comprises a liquid storage layer, the liquid storage layer is provided with at least a first flow channel and a second flow channel, the first flow channel is used for storing glue liquid A, and the second flow channel is used for storing glue liquid B; a mixing layer is arranged adjacent to the liquid storage layer, the mixing layer is provided with a third flow channel communicated with the first flow channel, a fourth flow channel communicated with the second flow channel, and a fifth flow channel communicated with the third flow channel and the fourth flow channel; a release layer is provided with a sixth flow channel, the sixth flow channel is communicated with the fifth flow channel, and a plurality of glue outlets are arranged on the side, away from the mixing layer, of the release layer. The medical micro-flow channel patch of the application solves the contradiction between strong adhesion and micro-invasive operation through the three-layer integrated micro-flow control structure of liquid storage, mixing and release, and inflammation problems and foreign body reactivity caused by puncture are avoided.

Description

Technical Field

[0001] This invention relates to the field of medical devices, and more particularly to a medical microfluidic patch. Background Technology

[0002] Tendon rupture is a common sports medicine injury, and its repair techniques have been continuously evolving. Currently, the closest existing technical solutions mainly include traditional suture fixation and early adhesive fixation, but each has significant drawbacks:

[0003] Traditional suture fixation methods suffer from damage. Current techniques use sutures or PET wires, which are pierced and fixed inside the muscle like a fishing net. This mechanical fixation method requires multiple punctures into the already damaged tendon during surgery, which itself causes additional iatrogenic tissue damage, hinders postoperative healing, and easily leads to chronic inflammation or foreign body reactions.

[0004] Currently, numerous studies have focused on the application of hydrogel bonding technology in the fixation and repair of ruptured tendons. This technology can effectively avoid tissue damage caused by traditional suture puncture of tendons, and its clinical application value has been confirmed. However, hydrogel bonding technology still has many problems that need to be solved: First, hydrogels mostly adopt an A+B two-component cross-linking form, which requires in vitro mixing before use, making the operation process relatively cumbersome; in addition, in order to ensure the adhesive strength required for tendon repair, the adhesive must have strong viscosity, which causes the adhesive to easily adhere to the surrounding non-torn tissue during the operation, thus limiting its minimally invasive application. Therefore, when hydrogels are used to treat tendon injuries, open surgery is still required.

[0005] However, rotator cuff repair currently mostly uses arthroscopic minimally invasive surgery. During the surgery, the patch needs to be curled up into a ball and delivered to the injury site through a narrow surgical channel before being unfolded and positioned. The strong adhesive of the pre-applied glue can cause the patch to easily stick to surgical instruments or surrounding normal tissue during installation, resulting in patch positioning deviation and, in severe cases, even surgical failure.

[0006] In view of this, it is necessary to improve existing medical patches in order to solve the above problems. Summary of the Invention

[0007] The purpose of this invention is to provide a medical microfluidic patch to solve the problems of existing suture fixation which easily leads to inflammation or foreign body reaction, and the difficulty of adhesive fixation installation.

[0008] To achieve the above objectives, the present invention provides a medical microfluidic patch, the medical microfluidic patch comprising:

[0009] A liquid storage layer, wherein the liquid storage layer has at least a first flow channel and a second flow channel, wherein the first flow channel stores adhesive A and the second flow channel stores adhesive B;

[0010] A mixing layer is disposed adjacent to the liquid storage layer. The mixing layer has a third flow channel communicating with the first flow channel, a fourth flow channel communicating with the second flow channel, and a fifth flow channel communicating with both the third and fourth flow channels. Adhesive A in the first flow channel enters the fifth flow channel through the third flow channel, and adhesive B in the second flow channel enters the fifth flow channel through the fourth flow channel. Adhesive A and adhesive B are mixed in the fifth flow channel to form an adhesive liquid.

[0011] The release layer has a sixth flow channel that is connected to the fifth flow channel. The release layer has multiple adhesive outlets on the side away from the mixing layer. The adhesive outlets are connected to the sixth flow channel and are located on the side of the release layer away from the mixing layer. The adhesive flows into the sixth flow channel from the fifth flow channel and then exits from the adhesive outlets.

[0012] As a further improvement of the present invention, the fifth flow channel extends along the bend in the mixing layer.

[0013] As a further improvement of the present invention, the third flow channel and the fourth flow channel are bent and extended within the mixing layer.

[0014] As a further improvement of the present invention, there are multiple third and fourth flow channels, the fifth flow channel is located in the middle of the mixing layer, and multiple third and fourth flow channels are located on both sides of the fifth flow channel.

[0015] As a further improvement of the present invention, a drug is added to adhesive A and / or adhesive B.

[0016] As a further improvement of the present invention, the substrates of the liquid storage layer, the mixing layer and the release layer are made of silicone, PDMS or PET.

[0017] As a further improvement of the present invention, the first flow channel includes a first flow channel body and a first pressure chamber disposed at one or both ends of the first flow channel body. By driving the first pressure chamber, the adhesive A flows from the first flow channel body into the third flow channel. The second flow channel includes a second flow channel body and a second pressure chamber disposed at one or both ends of the second flow channel body. By driving the second pressure chamber, the adhesive B flows from the second flow channel body into the fourth flow channel.

[0018] As a further improvement of the present invention, the first flow channel body is arranged in an arc-shaped reciprocating bending arrangement, and there are two second flow channels. The two second flow channel bodies are inserted between the first flow channel bodies from both sides, and a second pressure chamber is provided at the ends of the two second flow channels that are far apart from each other.

[0019] As a further improvement of the present invention, the medical microfluidic patch has a first state and a second state. When the medical microfluidic patch is in the first state, adhesive A and adhesive B are located in the first flow channel and the second flow channel, respectively. When the medical microfluidic patch is in the second state, adhesive A and adhesive B flow into the third flow channel and the fourth flow channel, respectively. By driving the first pressure chamber and the second pressure chamber, the medical microfluidic patch is changed from the first state to the second state. When the medical microfluidic patch is in the first state, adhesive A is located in the first flow channel body, and adhesive B is located in the second pressure chamber.

[0020] As a further improvement of the present invention, pressure relief chambers are provided in the liquid storage layer, the mixing layer and the release layer.

[0021] As a further improvement of the present invention, a plurality of the dispensing ports are arranged on one side of the release layer.

[0022] The beneficial effects of this invention are as follows: The medical microfluidic patch of this invention systematically solves the contradiction between strong adhesion and minimally invasive operation through a three-layer integrated microfluidic structure of liquid storage, mixing, and release. It also eliminates the inflammation and foreign body reaction problems that may be caused by puncture. The liquid storage layer stores non-adhesive adhesives A and B in separate compartments, ensuring non-adhesiveness during patch installation and positioning, greatly facilitating arthroscopic operation. The mixing layer, through a specific flow channel design, ensures thorough mixing of the two adhesives in proportion, guaranteeing reliable adhesion. The release layer, through an array of adhesive outlets, ensures uniform coverage of the interface with adhesive, enhancing repair strength. This design achieves controllable, uniform, and strong adhesion while avoiding suture puncture damage. Attached Figure Description

[0023] The accompanying drawings, which are included to provide a further understanding of this application and form part of this application, illustrate exemplary embodiments and are used to explain this application, but do not constitute an undue limitation of this application. In the drawings:

[0024] Figure 1 This is a schematic diagram of the overall vertical cross-sectional structure of the medical microfluidic patch of the present invention.

[0025] Figure 2 This is a schematic diagram of the cross-sectional structure of the liquid storage layer of the medical microfluidic patch of the present invention along the horizontal direction.

[0026] Figure 3 This is a schematic diagram of the back side of the liquid storage layer of the medical microfluidic patch of the present invention;

[0027] Figure 4 This is a schematic cross-sectional view of the hybrid layer of the medical microfluidic patch of the present invention along the horizontal direction.

[0028] Figure 5 This is a schematic diagram of the back structure of the hybrid layer of the medical microfluidic patch of the present invention;

[0029] Figure 6 This is a schematic diagram of the back structure of the release layer of the medical microfluidic patch of the present invention;

[0030] Figure 7 This is a schematic cross-sectional view of the release layer of the medical microfluidic patch of the present invention along the vertical direction.

[0031] Reference numerals: 100, Medical microfluidic patch; 1, Liquid reservoir; 11, First flow channel; 111, First flow channel body; 112, First pressure chamber; 12, Second flow channel; 121, Second flow channel body; 122, Second pressure chamber; 2, Mixing layer; 21, Third flow channel; 22, Fourth flow channel; 23, Fifth flow channel; 3, Release layer; 31, Sixth flow channel; 32, Dispensing port. Detailed Implementation

[0032] The technical solution of the present invention will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0033] In the description of this invention, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing the invention and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0034] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances. Furthermore, the technical features involved in the different embodiments of this invention described below can be combined with each other as long as they do not conflict with each other.

[0035] like Figures 1 to 7 As shown, the medical microfluidic patch 100 of the present invention includes a reservoir layer 1, a mixing layer 2, and a release layer 3. The medical microfluidic patch 100 can be applied to the treatment of tendon injuries such as rotator cuff tears, Achilles tendon tears, and patellar tendon tears, and can also be applied across fields such as ligament repair and fracture healing to repair the junction of hard and soft tissues. In this embodiment, the treatment of tendon injuries is used as an example for illustration.

[0036] The reservoir 1 has at least a first flow channel 11 and a second flow channel 12. The first flow channel 11 stores adhesive A, and the second flow channel 12 stores adhesive B. Adhesive A and adhesive B are not viscous, but can achieve adhesion between tendons after mixing. In one embodiment, adhesive A and adhesive B are mixed to form a hydrogel.

[0037] The mixing layer 2 is disposed adjacent to the liquid storage layer 1. The mixing layer 2 is provided with a third flow channel 21 that communicates with the first flow channel 11, a fourth flow channel 22 that communicates with the second flow channel 12, and a fifth flow channel 23 that communicates with both the third flow channel 21 and the fourth flow channel 22. The adhesive A in the first flow channel 11 enters the fifth flow channel 23 through the third flow channel 21, and the adhesive B in the second flow channel 12 enters the fifth flow channel 23 through the fourth flow channel 22. The adhesive A and adhesive B are mixed in the fifth flow channel 23 to form an adhesive liquid.

[0038] By storing the non-adhesive adhesive A and adhesive B separately and mixing them thoroughly with the mixing layer 2 only before application, the problem of difficult patch installation caused by excessive adhesiveness in pre-applied adhesive solutions is solved. This allows doctors to trigger the mixing of the adhesives to form a strong adhesive liquid after the patch is accurately positioned, achieving a firm bond to the tendon and completely avoiding additional iatrogenic damage to the tendon caused by multiple punctures in traditional suture fixation methods.

[0039] The two adhesives are guided to the fifth channel 23 for merging via the third channel 21 and the fourth channel 22. This structure ensures that adhesive A and adhesive B can be mixed in a preset, precise ratio, which is a key prerequisite for forming an adhesive with the expected bonding strength and fundamentally avoids bonding failure caused by improper mixing ratio.

[0040] The release layer 3 is provided with a sixth flow channel 31, which is connected to the fifth flow channel 23. The release layer 3 is provided with a plurality of glue outlets 32 on the side away from the mixing layer 2. The glue outlets 32 are connected to the sixth flow channel 31 and are located on the side of the release layer 3 away from the mixing layer 2. The adhesive flows into the sixth flow channel 31 from the fifth flow channel 23 and then exits from the glue outlets 32.

[0041] The adhesive liquid from the mixing layer 2 is collected through the sixth flow channel 31, and the adhesive liquid is uniformly and controllably sprayed onto the contact interface between the patch and the tendon using multiple adhesive outlets 32 distributed on the patch surface, thereby ensuring the stability and reliability of the adhesive strength and avoiding local adhesive failure.

[0042] In this embodiment, the fifth flow channel 23 extends along the bending direction of the mixing layer 2. The curved fifth flow channel 23, combined with the laminar flow characteristics of microfluidics, can effectively limit the flow disturbance of adhesive A and adhesive B, avoiding premature mixing or proportion deviation caused by uneven flow rates in straight channels. This ensures that the two adhesives can advance synchronously at a uniform and consistent flow rate, laying a reliable foundation for subsequent mixing in precise proportions.

[0043] The curved fifth flow channel 23 not only extends the contact path and mixing time of the two adhesives, but also breaks down the interfacial layer between the adhesives by generating a secondary flow effect, significantly increasing the contact area and thus achieving deep and uniform mixing under stirring-free conditions. This directly ensures the consistency and reliability of the adhesive properties of the final adhesive solution.

[0044] The third flow channel 21 and the fourth flow channel 22 extend in a bent manner within the mixing layer 2. The bent and extended structure of the third and fourth flow channels 21 and 22, combined with the "laminar flow guidance" characteristics of microfluidics, effectively limits the disturbance of adhesive A and adhesive B during the flow process. This design avoids problems such as uneven flow rate and local crossflow that may occur in straight channels, ensuring that the two adhesives can be simultaneously propelled to the fifth flow channel 23 at a uniform and consistent flow rate. This lays a reliable foundation for subsequent thorough mixing in precise proportions and fundamentally solves the core hidden danger of imbalanced proportions due to flow rate fluctuations before mixing.

[0045] The third flow channel 21 and the fourth flow channel 22 are both multiple, and the fifth flow channel 23 is located in the middle of the mixing layer 2, with the multiple third flow channels 21 and the fourth flow channels 22 located on both sides of the fifth flow channel 23. By distributing the multiple third flow channels 21 and the fourth flow channels 22 on both sides of the fifth flow channel 23, a biomimetic multi-channel confluence structure similar to fish gills is formed. This design can significantly increase the contact interface and mixing path between adhesive A and adhesive B, and further improve the mixing uniformity through staggered confluence, ensuring that the final adhesive has consistent and reliable performance, thereby optimizing the bonding effect of the medical microchannel patch 100.

[0046] In this embodiment, the side of the reservoir layer 1 away from the mixing layer 2 is designated as the front side, the side facing the mixing layer 2 is designated as the back side, the side of the mixing layer 2 facing the reservoir layer 1 is designated as the front side, and the side facing the release layer 3 is designated as the back side, and the side of the release layer 3 facing the mixing layer 2 is designated as the front side, and the side facing the tendon is designated as the back side.

[0047] The back of the liquid storage layer 1 has multiple openings to connect to the first flow channel 11 and the second flow channel 12, respectively.

[0048] The front of the mixing layer 2 has multiple openings to connect the first flow channel 11 and the third flow channel 21, as well as the second flow channel 12 and the fourth flow channel 22, respectively. The back of the mixing layer 2 has a row of openings facing the release layer 3 in the middle to connect the fifth flow channel 23 and the sixth flow channel 31.

[0049] The release layer 3 has a row of openings facing the mixing layer 2 in the middle of the front side, and an adhesive outlet 32 ​​on the back side.

[0050] It should be noted that the liquid storage layer 1, the mixing layer 2, and the release layer 3 are only used to define different flow channels. The three can be bonded together as separate structures or as an integral structure.

[0051] The adhesive A and / or adhesive B contain added medications. These medications include, but are not limited to, healing-inducing substances, anti-inflammatory drugs, and antibacterial drugs. Healing-inducing substances are bioactive factors that stimulate cell proliferation, differentiation, and matrix synthesis, directly accelerating the repair process of damaged tissue. Anti-inflammatory or anti-adhesion drugs promote healing while controlling local inflammatory responses or preventing abnormal adhesions between tissues, thus optimizing the repair effect. Antibacterial drugs reduce the risk of surgical site infection, creating a clean environment for tissue healing. These medications can be used alone or in combination.

[0052] By directly integrating the drug into the adhesive, the medical microfluidic patch 100 can release active drugs directly at the damaged site while performing its mechanical fixation function, initiating a biological repair process. This achieves the integration of "fixation" and "treatment," overcoming the limitations of traditional patches that only provide mechanical support and lack biological activity.

[0053] The medication is precisely delivered to the interface between the tendon and the patch using an adhesive solution—the critical area most in need of promoting healing. This localized, targeted drug delivery method significantly increases local drug concentration and reduces the side effects of systemic medication, thereby improving treatment efficiency and safety.

[0054] The substrates for the reservoir layer 1, mixing layer 2, and release layer 3 are made of silicone, PDMS (polydimethylsiloxane), or PET (polyethylene terephthalate). Silicone, PDMS, and PET materials have good resistance to rejection by the human body, can be easily prepared through injection molding, and are elastic enough to bend without breaking. This ensures that patches made from these materials, after implantation, can minimize the risk of rejection and inflammation, providing a safe and reliable biological environment for tendon repair—a primary prerequisite for medical implants. These substrates can be injection molded and cast, ensuring that the complex three-layer microchannel structure of the medical microchannel patch 100 can be manufactured precisely and efficiently, and is compatible with manufacturing technologies such as 3D printing of silicone.

[0055] The first flow channel 11 includes a first flow channel body 111 and a first pressure chamber 112 disposed at one or both ends of the first flow channel body 111. By driving the first pressure chamber 112, the adhesive A flows from the first flow channel body 111 into the third flow channel 21. The second flow channel 12 includes a second flow channel body 121 and a second pressure chamber 122 disposed at one or both ends of the second flow channel body 121. By driving the second pressure chamber 122, the adhesive B flows from the second flow channel body 121 into the fourth flow channel 22.

[0056] By driving a specific first pressure chamber 112 or second pressure chamber 122, the timing and flow rate of adhesive A and adhesive B flowing from their respective flow channels to the mixing layer 2 can be independently and precisely controlled. This design allows surgeons to actively trigger the mixing and release of the adhesive after the medical microchannel patch 100 is accurately positioned at the rotator cuff injury site during arthroscopic surgery, perfectly solving the installation and positioning difficulties caused by the strong adhesion of pre-applied adhesive solutions.

[0057] By coordinating the driving of the first pressure chamber 112 and the second pressure chamber 122, adhesive A and adhesive B can enter the mixing layer 2 at a stable and synchronized flow rate. This lays a solid foundation for achieving thorough mixing in precise proportions in the fifth flow channel 23, ensuring the reliability of the final adhesive solution from the source.

[0058] The first flow channel body 111 is arranged in an arc-shaped reciprocating bend. There are two second flow channels 12. The two second flow channel bodies 121 are inserted between the first flow channel bodies 111 from both sides. The two second flow channels 12 are provided with a second pressure chamber 122 at the ends that are far apart from each other.

[0059] By nesting the first flow channel body 111, which bends back and forth in an arc shape, with the second flow channel bodies 121 inserted on both sides, the utilization efficiency of the internal space of the medical microfluidic patch 100 is greatly improved. This compact layout maximizes the storage capacity of adhesive A and adhesive B within a limited planar area, providing a foundation for more thorough mixing in the future and is key to the miniaturization and integrated design of the patch structure.

[0060] The medical microfluidic patch 100 has a first state and a second state. When the medical microfluidic patch 100 is in the first state, adhesive A and adhesive B are located in the first channel 11 and the second channel 12, respectively. When the medical microfluidic patch 100 is in the second state, adhesive A and adhesive B flow into the third channel 21 and the fourth channel 22, respectively. By driving the first pressure chamber 112 and the second pressure chamber 122, the medical microfluidic patch 100 is changed from the first state to the second state. When the medical microfluidic patch 100 is in the first state, adhesive A is located in the first channel body 111 and adhesive B is located in the second pressure chamber 122.

[0061] The first state can be understood as a storage or preparation state, while the second state can be understood as a mixing or release state. The medical microfluidic patch 100 utilizes the first pressure chamber 112 and the second pressure chamber 122 as controllable drive switches to achieve precise timing control of the adhesive mixing and release process, thereby ensuring the safety and reliability of the surgical operation. Specifically, this design allows the surgeon to be in the first state during the installation, curling, and positioning of the medical microfluidic patch 100, ensuring that adhesives A and B are safely isolated and do not interfere with each other. Only after the medical microfluidic patch 100 is precisely positioned, the pressure chamber is actively driven to trigger the medical microfluidic patch 100 to switch to the second state, initiating the directional flow and mixing of the adhesive. This fundamentally avoids premature mixing of the adhesive due to accidental squeezing or manipulation, perfectly resolving the contradiction between the "strong adhesion requirement" and "precise positioning operation" in arthroscopic minimally invasive surgery.

[0062] Each of the liquid storage layer 1, mixing layer 2, and release layer 3 is equipped with a pressure relief chamber. The pressure relief chamber is a specific cavity structure integrated into the three-layer flow channel system of the medical microfluidic patch 100. It is a pressure buffer cavity specially designed to address the critical operation of curling the patch into a ball during installation. When the medical microfluidic patch 100 is clamped or curled by instruments during surgical installation, the internal flow channel system will generate instantaneous pressure due to deformation. As a reserved cavity or low-pressure area, the pressure relief chamber can preferentially absorb and release this abnormal pressure, thereby preventing the pressure from being directly and completely transmitted to the flow channel body storing the adhesive. This prevents the adhesive from prematurely breaking through the isolation layer and entering the mixing layer 2 due to accidental pressure, and prevents the adhesive from being prematurely mixed and released. In addition, the pressure relief chamber can also ensure the reliable positioning of the medical microchannel patch 100 and prevent premature adhesion. The pressure relief chamber ensures that the doctor can smoothly stretch the patch and accurately place it at the rotator cuff tear without the patch accidentally adhering to the instrument or surrounding tissue, which greatly improves the operability and success rate of the surgery.

[0063] Multiple adhesive outlets 32 are arranged in an array on one side of the release layer 3. The adhesive outlets 32 can be arranged in a circular array or a rectangular array, mainly depending on the medical microfluidic patch 100. The principle is to cover as much of the medical microfluidic patch 100 and the base surface of the tendon as possible, so that the mixed adhesive can be sprayed evenly and comprehensively to cover the entire contact interface between the patch and the tendon. This effectively avoids local adhesive failure caused by uneven distribution of adhesive, thereby ensuring the stability and reliability of the overall adhesive strength of the patch and greatly improving the success rate of the repair surgery.

[0064] The working process of the medical microfluidic patch 100 of the present invention is as follows:

[0065] Safe storage and preparation:

[0066] The medical microfluidic patch 100 is in its first state (storage state) before implantation and during installation and positioning.

[0067] Adhesive A is stored in the first flow channel body 111, and adhesive B is stored in the second pressure chamber 122.

[0068] The pressure relief chambers in each layer effectively buffer the pressure generated by the curling and clamping of the patch, ensuring strict isolation between the two adhesives. The medical microfluidic patch 100 is non-adhesive overall, which facilitates flexible operation and precise positioning by doctors under arthroscopy.

[0069] Active triggering and driving (state transition):

[0070] After the medical microfluidic patch 100 is accurately positioned at the site of injury, the doctor uses a special instrument (such as surgical forceps) to press the first pressure chamber 112 and the second pressure chamber 122 on the fluid reservoir 1.

[0071] This actively drives adhesive A and adhesive B to flow out from their respective storage areas and into the third flow channel 21 and the fourth flow channel 22 corresponding to the mixing layer 2. The medical microfluidic patch 100 thus transitions from the first state to the second state (mixing / release state).

[0072] Adhesives A and B are guided to the fifth channel 23 at a stable and synchronized flow rate through the third and fourth channels 21 and 22, which are bent and extended.

[0073] In the fifth flow channel 23, which extends along the bend, the two adhesives are physically mixed in a precise ratio and uniformly during the flow process by means of microfluidic laminar flow and secondary flow effects, forming a hydrogel adhesive with strong viscosity.

[0074] Uniform release and final fixation (completion of repair):

[0075] The mixed adhesive flows into the sixth channel 31 of the release layer 3 and is evenly sprayed out through multiple adhesive outlets 32 arranged in an array on the bottom side of the medical microchannel patch 100, fully covering the contact interface between the patch and the tendon.

[0076] The doctor then applied pressure to the medical microfluidic patch 100 to ensure it adhered tightly to the tissue, maintaining pressure until the adhesive solidified. Thus, the medical microfluidic patch 100, through a combination of chemical adhesion and mechanical fixation, firmly repaired the tendon injury, while the loaded medication was continuously released locally to promote healing.

[0077] The medical microfluidic patch 100 of this invention systematically solves the contradiction between strong adhesion and minimally invasive operation through a three-layer integrated microfluidic structure of liquid storage, mixing, and release. It also eliminates the inflammation and foreign body reaction problems that may be caused by puncture. The liquid storage layer 1 stores non-adhesive adhesives A and B in separate compartments, ensuring non-adhesiveness during patch installation and positioning, greatly facilitating arthroscopic operation. The mixing layer 2 achieves thorough mixing of the two adhesives in a specific flow channel design, ensuring reliable adhesion. The release layer 3 uses an array of adhesive outlets 32 to uniformly cover the interface with adhesive, improving repair strength. This design achieves controllable, uniform, and strong adhesion while avoiding suture puncture damage.

[0078] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0079] The embodiments described above are merely illustrative of several implementations of the present invention, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the invention patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these all fall within the protection scope of the present invention. Therefore, the protection scope of this invention patent should be determined by the appended claims.

Claims

1. A medical microfluidic patch, characterized by: The medical microfluidic patch includes: A liquid storage layer, wherein the liquid storage layer has at least a first flow channel and a second flow channel, wherein the first flow channel stores adhesive A and the second flow channel stores adhesive B; A mixing layer is disposed adjacent to the liquid storage layer. The mixing layer has a third flow channel communicating with the first flow channel, a fourth flow channel communicating with the second flow channel, and a fifth flow channel communicating with both the third and fourth flow channels. Adhesive A in the first flow channel enters the fifth flow channel through the third flow channel, and adhesive B in the second flow channel enters the fifth flow channel through the fourth flow channel. Adhesive A and adhesive B are mixed in the fifth flow channel to form an adhesive liquid. The first flow channel includes a first flow channel body and a first pressure chamber disposed at one or both ends of the first flow channel body. By driving the first pressure chamber, the adhesive A flows from the first flow channel body into the third flow channel. The second flow channel includes a second flow channel body and a second pressure chamber disposed at one or both ends of the second flow channel body. By driving the second pressure chamber, the adhesive B flows from the second flow channel body into the fourth flow channel. The release layer has a sixth flow channel that is connected to the fifth flow channel. The release layer has multiple adhesive outlets on the side away from the mixing layer. The adhesive outlets are connected to the sixth flow channel and are located on the side of the release layer away from the mixing layer. The adhesive flows into the sixth flow channel from the fifth flow channel and then exits from the adhesive outlets.

2. The medical microfluidic patch according to claim 1, characterized in that: The fifth flow channel extends along the bend in the mixing layer.

3. The medical microfluidic patch according to claim 2, characterized in that: The third and fourth flow channels bend and extend within the mixing layer.

4. The medical microfluidic patch according to claim 1, characterized in that: There are multiple third and fourth flow channels, and the fifth flow channel is located in the middle of the mixing layer, with multiple third and fourth flow channels located on both sides of the fifth flow channel.

5. The medical microfluidic patch according to claim 1, characterized in that: The adhesive A and / or adhesive B contain added drugs.

6. The medical microfluidic patch according to claim 1, characterized in that: The substrates for the reservoir layer, mixing layer, and release layer are made of silicone, PDMS, or PET.

7. The medical microfluidic patch according to claim 1, characterized in that: The first flow channel body is arranged in an arc-shaped reciprocating bend. There are two second flow channels. The two second flow channel bodies are inserted between the first flow channel bodies from both sides. A second pressure chamber is provided at the ends of the two second flow channels that are far apart from each other.

8. The medical microfluidic patch according to claim 7, characterized in that: The medical microfluidic patch has a first state and a second state. When the medical microfluidic patch is in the first state, adhesive A and adhesive B are located in the first flow channel and the second flow channel, respectively. When the medical microfluidic patch is in the second state, adhesive A and adhesive B flow into the third flow channel and the fourth flow channel, respectively. By driving the first pressure chamber and the second pressure chamber, the medical microfluidic patch is changed from the first state to the second state. When the medical microfluidic patch is in the first state, adhesive A is located in the first flow channel body, and adhesive B is located in the second pressure chamber.

9. The medical microfluidic patch according to claim 1, characterized in that: Each of the liquid storage layer, mixing layer, and release layer is equipped with a pressure relief chamber.

10. The medical microfluidic patch according to claim 1, characterized in that: Multiple dispensing ports are arranged in an array on one side of the release layer.

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