Ramelteon bulk drug production device

Abstract

The invention relates to the field of stirring facilities, in particular to a ramelteon bulk drug production device which comprises a stirring box, a plate seat is fixedly mounted at the upper end of the stirring box, a reciprocating lead screw is rotatably mounted at the rear end of the plate seat, and a driving motor is fixedly mounted at the edge of the upper end of a base of the stirring box. The driving motor is connected with a stirring shaft of the stirring box, a speed reduction assembly is arranged between the reciprocating lead screw and the driving motor, a sliding block is arranged on the outer surface of the reciprocating lead screw, a guide rod is fixedly installed at the position, close to the upper portion of the reciprocating lead screw, of the rear end of the plate base, and a sliding sleeve is slidably installed on the outer surface of the guide rod. A feeding hopper is installed on the upper end face of the plate base in an attached mode, the sliding sleeve is fixed to the feeding hopper and the sliding block, and a storage hopper is fixedly installed above one end of the plate base. According to the invention, the use convenience is improved, the reaction is more stable, and the safety is ensured.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of stirring facilities, in particular to a ramelteon raw material drug production device. BACKGROUND

[0002] Ramelteon is a drug for treating insomnia, especially suitable for patients with difficulty falling asleep. In the production process of ramelteon, stirring facilities are often used to stir the raw materials of ramelteon, and alkali is also added in batches during the stirring process to facilitate the reaction between the raw materials.

[0003] However, in the process of using the existing stirring facilities, the addition of alkali is mostly manual, that is, after the addition of alkali, the raw materials are stirred for a period of time, then the alkali is added again, and the stirring is carried out again for a period of time, and the process is repeated to complete the batch addition of alkali. It needs to be added manually in batches for several times, which is quite cumbersome to operate, resulting in inconvenience in use. SUMMARY

[0004] The purpose of the present application is to solve the shortcomings in the background art and provide a ramelteon raw material drug production device.

[0005] To achieve the above purpose, the technical scheme adopted by the present application is as follows: a ramelteon raw material drug production device, comprising a stirring box, a plate seat is fixedly installed at the upper end of the stirring box, a reciprocating lead screw is rotatably installed at the rear end of the plate seat, a drive motor is fixedly installed at the upper end edge of the base of the stirring box, the drive motor is connected with the stirring shaft of the stirring box, a speed reduction assembly is arranged between the reciprocating lead screw and the drive motor, a sliding block is arranged on the outer surface of the reciprocating lead screw, a guide rod is fixedly installed above the reciprocating lead screw at the rear end of the plate seat, a sliding sleeve is slidably installed on the outer surface of the guide rod, a feeding hopper is attached to the upper end surface of the plate seat, the sliding sleeve is fixedly connected with the feeding hopper and the sliding block, a storage hopper is fixedly installed at one end of the plate seat, the lower end surface of the storage hopper is flush with the upper end surface of the feeding hopper, the top of the feeding hopper is matched with the bottom of the storage hopper, an elastic sealing plate is elastically installed at the lower end of the storage hopper, and a quantity placing part is arranged at the lower end of the plate seat.

[0006] Preferably, a column seat is fixedly installed on the side surface of the storage hopper, guide columns are slidably installed at both ends of the column seat, one end of the guide column is fixedly connected with the sealing plate, and the other end of the guide column is coaxially embedded with a limiting cap, and the limiting cap is attached to one side of the column seat.

[0007] Preferably, a return spring is wound around the outer side of the guide column, one end of the return spring is fixedly connected with one end of the guide column, and the other end of the return spring is fixedly connected with the other side of the column seat.

[0008] Preferably, the speed reduction assembly comprises a first small pulley coaxially embedded on the output end of the driving motor, the side of the stirring box is rotatably provided with a connecting shaft, the outer surface of the connecting shaft is coaxially embedded with a second large pulley, the first small pulley and the second large pulley are connected with a first belt, the outer surface of the connecting shaft is coaxially embedded with a second small pulley on the side close to the second large pulley, the end of the reciprocating lead screw is coaxially embedded with a first large pulley, and the first large pulley and the second small pulley are connected with a second belt.

[0009] Preferably, the component feeding part comprises three sub-hoppers linearly and fixedly arranged at the lower end of the plate base, the upper end of the sub-hopper extends to the upper end surface of the plate base, the interior of the sub-hopper is provided with two partitions, the rear end of the plate base is linearly and elastically provided with three prongs, the lower end of the sub-hopper is fitted with a discharging seat, the discharging seat is fixed with the lower end of the prong, the rear end upper edge of the three prongs is extended with a prong ear, the length of the three prong ears increases in turn, the front end of the feeding hopper is rotatably provided with a prong claw, and the bottom of the feeding hopper is matched with the sub-hopper.

[0010] Preferably, the outer surface of the three prongs is coaxially embedded with a connecting pulley at the lower part, the connecting pulleys on the adjacent two prongs are connected with a synchronous belt, the middle part of the prong claw is rotatably provided with an adaptive column, the outer surface of the adaptive column is elastically provided with an adaptive shell, the end of the adaptive shell is rotatably connected with the feeding hopper, the middle part of the prong is rotatably provided with an extension seat, the end of the extension seat is fixed with the plate base, the side of the extension seat is extended with a limiting frame, the end of the limiting frame is on the prong ear, the side of the feeding hopper is fixedly provided with a fixed claw frame, and the end of the fixed claw frame is on the prong claw.

[0011] Preferably, the outer side of the prong is wound with a torsional spring, one end of the torsional spring is fixed with the extension seat, and the other end of the torsional spring is fixed with the upper end of the prong.

[0012] Preferably, the end of the adaptive column is coaxially embedded with a positioning cap, the positioning cap is slidably arranged in the interior of the adaptive shell, the end of the positioning cap is fixedly provided with a spring body, and the end of the spring body is fixed with the rear end of the interior of the adaptive shell.

[0013] Compared with the prior art, the present application has the following beneficial effects:

[0014] 1. When the drive motor rotates the stirring shaft on the mixing tank to stir the raw materials, it also drives the reciprocating screw to rotate slowly through the reduction assembly, which in turn drives the slider to move slowly back and forth. As the slider drives the feeding hopper to move slowly towards the storage hopper, alkali is added into the mixing tank. When the slider drives the feeding hopper to move slowly in the opposite direction, the addition of alkali stops, allowing the raw materials in the mixing tank to be stirred for a period of time. This cycle is repeated to automatically add alkali in batches. The process does not require manual batch addition, which effectively improves the ease of use.

[0015] 2. As the feeding hopper slowly moves in the reverse direction, the alkali in the feeding hopper will fall and fill the three distribution hoppers in sequence. During this process, the positioning of the limiting frame pushes the claw along the inclined surface of the claw, causing the claw to rotate and pass smoothly through the limiting frame. At the same time, the discharge seat remains closed. As the feeding hopper slowly moves towards the storage hopper, the claw, positioned by the fixed claw frame, pushes the first limiting frame on the moving path. This causes the three claws to rotate synchronously via the timing belt, which in turn opens the discharge seat partially, allowing the alkali in the first compartment of the three distribution hoppers to be discharged. Since the length of the levers increases sequentially, when the second lever is pushed by the lever claw, the rotation angle of the lever column will increase. At this time, the opening range of the discharge seat will also increase, so that the alkali in the second compartment of the three distribution hoppers can be discharged. This process continues until all the alkali in the three distribution hoppers is discharged. This allows for multi-point addition through the three distribution hoppers, and the alkali in the multiple compartments of the distribution hoppers can be discharged sequentially in an intermittent manner. This controls the amount and speed of alkali added in a single batch, making the reaction more stable, ensuring safety, and avoiding the phenomenon of excessively violent local reactions caused by the rapid and concentrated addition of a large amount of alkali in a single batch. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of a rameltetinamide raw material production device according to the present invention;

[0017] Figure 2 This is a rear view of a rameltetinamide active pharmaceutical ingredient production apparatus according to the present invention;

[0018] Figure 3 This invention relates to a production apparatus for ramelteline amide raw material. Figure 1 Enlarged view of A in the middle;

[0019] Figure 4 This invention relates to a production apparatus for ramelteline amide raw material. Figure 1 Enlarged view of B in the middle;

[0020] Figure 5 This invention relates to a production apparatus for ramelteline amide raw material. Figure 1 Enlarged view of C;

[0021] Figure 6 Figure 1 is a schematic view of a pawl for a ramelteon bulk drug production device of the present application;

[0022] Figure 7 Figure 2 is a schematic view of a storage hopper for a ramelteon bulk drug production device of the present application;

[0023] Figure 8 Figure 3 is an internal view of an adaptive shell for a ramelteon bulk drug production device of the present application;

[0024] Figure 9 Figure 4 is a schematic view of a distribution hopper for a ramelteon bulk drug production device of the present application.

[0025] In the figure: 1, stirring box; 2, drive motor; 3, guide rod; 4, reciprocating screw; 5, feeding hopper; 6, sliding sleeve; 7, sliding block; 8, plate seat; 9, No. 1 large pulley; 10, positioning cap; 11, storage hopper; 12, pawl; 13, sealing plate; 14, return spring; 15, guide column; 16, limit cap; 17, column seat; 18, No. 1 small pulley; 19, No. 1 belt; 20, connecting shaft; 21, No. 2 small pulley; 22, No. 2 large pulley; 23, No. 2 belt; 24, distribution hopper; 25, synchronous belt; 26, pawl column; 27, connecting pulley; 28, extension seat; 29, limit frame; 30, pawl ear; 31, torsional spring; 32, spring body; 33, adaptive shell; 34, adaptive column; 35, partition plate; 36, detent frame; 37, discharge seat. DETAILED DESCRIPTION

[0026] The following description is provided to enable any person skilled in the art to practice the application as claimed. The preferred embodiments disclosed herein are only examples of the application and variations can be made by persons skilled in the art based on the teachings described herein.

[0027] As Figures 1-9The device for producing ramelteon raw medicine shown includes a stirring box 1, a plate seat 8 is fixedly installed at the upper end of the stirring box 1, a reciprocating lead screw 4 is rotatably installed at the rear end of the plate seat 8, a driving motor 2 is fixedly installed at the upper end edge of the base of the stirring box 1, the driving motor 2 is connected with the stirring shaft of the stirring box 1, a speed reduction assembly is arranged between the reciprocating lead screw 4 and the driving motor 2, a sliding block 7 is arranged on the outer surface of the reciprocating lead screw 4, the reciprocating lead screw 4 and the sliding block 7 play a role of driving the feeding hopper 5 to move reciprocally, a guide rod 3 is fixedly installed above the reciprocating lead screw 4 at the rear end of the plate seat 8, a sliding sleeve 6 is slidably installed on the outer surface of the guide rod 3, the feeding hopper 5 is attached and installed on the upper end surface of the plate seat 8, the plate seat 8 can block the bottom of the feeding hopper 5 to avoid the alkali in the feeding hopper 5 from falling during the movement, the guide rod 3 and the sliding sleeve 6 play a role of guiding the feeding hopper 5, the sliding sleeve 6 is fixed with the feeding hopper 5 and the sliding block 7 respectively, a storage hopper 11 is fixedly installed at one end of the plate seat 8, the storage hopper 11 plays a role of storing the alkali, the lower end surface of the storage hopper 11 is flush with the upper end surface of the feeding hopper 5, the top of the feeding hopper 5 is adapted to the bottom of the storage hopper 11, the bottom of the feeding hopper 5 and the bottom of the storage hopper 11 can be aligned, the alkali in the storage hopper 11 can fall smoothly and fill the feeding hopper 5, an enclosing plate 13 is elastically installed at the lower end of the storage hopper 11, and a quantity placing part is arranged at the lower end of the plate seat 8, the enclosing plate 13 can block the bottom of the storage hopper 11.

[0028] A column seat 17 is fixedly installed on the side of the storage hopper 11, guide columns 15 are slidably installed at the two ends of the column seat 17, the column seat 17 and the guide columns 15 play a role of guiding the enclosing plate 13, one end of the guide column 15 is fixed with the enclosing plate 13, the other end of the guide column 15 is coaxially embedded with a limiting cap 16, the limiting cap 16 is attached to one side of the column seat 17, and the limiting cap 16 plays a role of positioning the reset position of the enclosing plate 13.

[0029] A reset spring 14 is wound on the outer side of the guide column 15, one end of the reset spring 14 is fixed with one end of the guide column 15, the other end of the reset spring 14 is fixed with the other side of the column seat 17, and the reset spring 14 plays a role of resetting the moved enclosing plate 13, when the feeding hopper 5 moves to below the storage hopper 11, the feeding hopper 5 will jolt the enclosing plate 13, the enclosing plate 13 will be laterally moved, the bottom of the storage hopper 11 will be opened, and the alkali can fall into the feeding hopper 5, when the feeding hopper 5 is separated from below the storage hopper 11, the reset spring 14 will push the enclosing plate 13 to reset, so as to block the bottom of the storage hopper 11 again.

[0030] The speed reduction assembly comprises a first small pulley 18 coaxially embedded in the output end of the driving motor 2, a connecting shaft 20 is rotatably installed on the side of the stirring box 1, the connecting shaft 20 serves to connect a second large pulley 22 and a second small pulley 21, the outer surface of the connecting shaft 20 coaxially embeds the second large pulley 22, the first small pulley 18 is connected with the second large pulley 22 through a first belt 19, the outer surface of the connecting shaft 20 coaxially embeds the second small pulley 21 on the side close to the second large pulley 22, the end of the reciprocating lead screw 4 coaxially embeds a first large pulley 9, the first large pulley 9 is connected with the second small pulley 21 through a second belt 23, the first belt 19 and the second belt 23 serve to transmit power, the second large pulley 22 and the first small pulley 18, the first large pulley 9 and the second small pulley 21 all serve to reduce speed, so that the reciprocating lead screw 4 can rotate slowly.

[0031] The component dispensing part comprises three sub-hoppers 24 linearly fixedly installed at the lower end of the plate base 8, the upper end of the sub-hopper 24 extends to the upper end surface of the plate base 8, the three sub-hoppers 24 serve to add in multiple points, the inside of the sub-hopper 24 is provided with two partitions 35, the partitions 35 can divide the internal space of the sub-hopper 24 into multiple cells, so that only the alkali in one cell is added at a time when the alkali is added, three prongs 26 are linearly and elastically installed at the rear end of the plate base 8, a discharging seat 37 is attached to the lower end of the sub-hopper 24, the discharging seat 37 is fixed with the lower end of the prong 26, the prong 26 serves to drive the discharging seat 37 to open, the rear end upper edge of the three prongs 26 all extends a prong lug 30, the lengths of the three prong lugs 30 increase successively, which can increase the rotation angle of the prong 26, and further increase the opening amplitude of the discharging seat 37, the front end of the feeding hopper 5 is rotatably installed with a prong claw 12, the prong claw 12 serves to drive the prong lug 30, the bottom of the feeding hopper 5 is matched with the sub-hopper 24, which can align the bottom of the feeding hopper 5 with the top of the sub-hopper 24, so that the alkali in the feeding hopper 5 can smoothly fall and fill the sub-hopper 24.

[0032] The outer surface of the lower part of the three prongs 26 is coaxially embedded with a connecting pulley 27, wherein the connecting pulleys 27 on the adjacent two prongs 26 are connected with a synchronous belt 25, the connecting pulley 27 plays a role in connecting the synchronous belt 25, and the synchronous belt 25 plays a role in synchronizing the rotation of the three prongs 26, the middle part of the prong 12 is rotatably installed with an adaptive column 34, the outer surface of the adaptive column 34 is elastically installed with an adaptive shell 33, the end of the adaptive shell 33 is rotatably connected with the feeding hopper 5, the middle part of the prong 26 is rotatably installed with an extension seat 28, the end of the extension seat 28 is fixed with the plate seat 8, the extension seat 28 plays a role in bearing the prong 26, the side of the extension seat 28 extends a limiting frame 29, the end of the limiting frame 29 is on the prong ear 30, the limiting frame 29 can position the prong ear 30, so that the prong ear 30 can push the prong 12 along the inclined surface of the prong 12, so that the prong 12 rotates and smoothly passes through the prong ear 30, the side of the feeding hopper 5 is fixedly installed with a fixed claw frame 36, the end of the fixed claw frame 36 is on the prong 12, the fixed claw frame 36 can position the prong 12, so that the end of the prong 12 can push the prong ear 30, and in turn drive the prong 26 to rotate.

[0033] The outer side of the upper part of the prong 26 is wound with a torsion spring 31, one end of the torsion spring 31 is fixed with the extension seat 28, the other end of the torsion spring 31 is fixed with the upper end of the prong 26, and the torsion spring 31 plays a role in resetting the rotated prong 26.

[0034] The end of the adaptive column 34 is coaxially embedded with a positioning cap 10, the positioning cap 10 is slidably installed in the inside of the adaptive shell 33, the positioning cap 10 plays a role in preventing the adaptive column 34 and the adaptive shell 33 from separating, the end of the positioning cap 10 is fixedly installed with a spring body 32, the end of the spring body 32 is fixed with the inside rear end of the adaptive shell 33, and the spring body 32 can push the prong 12, so that the rotated prong 12 is reset.

[0035] When stirring, the driving motor 2 works to drive the stirring shaft on the stirring box 1 to rotate to stir the raw materials, and the driving motor 2 also drives the reciprocating screw rod 4 to rotate slowly through the speed reducer assembly, and then drives the sliding block 7 to move slowly and reciprocally, when the sliding block 7 drives the feeding hopper 5 to move slowly to the position below the storage hopper 11, the alkali in the storage hopper 11 falls to fill the feeding hopper 5, and then the sliding block 7 drives the feeding hopper 5 to move reversely slowly, at this time, the alkali in the feeding hopper 5 falls completely and fills the three distribution hoppers 24 in turn, in this process, the pushing lug 30 is positioned by the limiting frame 29 to push the pawl 12 along the inclined surface of the pawl 12 to rotate the pawl 12, so that the pawl 12 passes through the pushing lug 30 smoothly, and the discharge seat 37 remains in a closed state, when the feeding hopper 5 moves slowly to the direction of the storage hopper 11, the pawl 12 is positioned by the limiting frame 36, and the end portion thereof pushes the first pushing lug 30 on the moving path to rotate the three pushing columns 26 synchronously through the synchronous belt 25, and then drives the discharge seat 37 to open partially to discharge the alkali in the first compartment of the three distribution hoppers 24, since the lengths of the pushing lugs 30 increase in turn, when the second pushing lug 30 is pushed by the pawl 12, the rotation angle of the pushing column 26 increases, at this time, the opening amplitude of the discharge seat 37 also increases to discharge the alkali in the second compartment of the three distribution hoppers 24, and so on until the alkali in the three distribution hoppers 24 is discharged completely to complete the single batch feeding, when the feeding hopper 5 is moved to the position below the storage hopper 11 again by the sliding block 7, the alkali in the storage hopper 11 falls to fill the feeding hopper 5 again, and then the sliding block 7 drives the feeding hopper 5 to move reversely slowly again, in this process, the addition of the alkali is stopped to enable the raw materials in the stirring box 1 to be stirred for a period of time, and so on to add the alkali in batches automatically, and the process does not need to be added manually in batches.

[0036] The basic principle, main features and advantages of the present application are shown and described above. It should be understood by those skilled in the art that the present application is not limited by the above-mentioned embodiments, and the above-mentioned embodiments and descriptions in the specification are only the principles of the present application, and various changes and improvements can be made without departing from the spirit and scope of the present application, and these changes and improvements all fall within the scope of the claimed present application. The scope of protection claimed by the present application is defined by the appended claims and their equivalents.

Claims

1. A device for producing ramelteon bulk drug, comprising a stirring box (1), characterized in that: The upper end of the stirring box (1) is fixedly installed with a plate seat (8), the rear end of the plate seat (8) is rotatably installed with a reciprocating lead screw (4), the upper end edge of the base of the stirring box (1) is fixedly installed with a driving motor (2), the driving motor (2) is connected with the stirring shaft of the stirring box (1), a speed reduction assembly is arranged between the reciprocating lead screw (4) and the driving motor (2), the outer surface of the reciprocating lead screw (4) is provided with a sliding block (7), the rear end of the plate seat (8) is fixedly installed with a guide rod (3) above the reciprocating lead screw (4), the outer surface of the guide rod (3) is slidably installed with a sliding sleeve (6), the upper end surface of the plate seat (8) is abuttingly installed with a feeding hopper (5), the sliding sleeve (6) is fixed with the feeding hopper (5) and the sliding block (7) respectively, one end of the plate seat (8) is fixedly installed with a storage hopper (11), the lower end surface of the storage hopper (11) is flush with the upper end surface of the feeding hopper (5), the top of the feeding hopper (5) is matched with the bottom of the storage hopper (11), the lower end of the storage hopper (11) is elastically installed with a sealing plate (13), and the lower end of the plate seat (8) is provided with a component for throwing a certain amount.

2. The device for producing raw drug of ramelteon according to claim 1, characterized in that: The side of the storage hopper (11) is fixedly installed with a column seat (17), both ends of the column seat (17) are slidably installed with guide columns (15), one end of the guide column (15) is fixed with the sealing plate (13), and the other end of the guide column (15) is coaxially embedded with a limiting cap (16), and the limiting cap (16) is attached to one side of the column seat (17).

3. A device for producing raw drug of Ramelteon according to claim 2, characterized in that: The outer side of the guide column (15) is wound with a return spring (14), one end of the return spring (14) is fixed with one end of the guide column (15), and the other end of the return spring (14) is fixed with the other side of the column seat (17).

4. The device for producing raw drug of ramelteon according to claim 1, characterized in that: The speed reduction assembly comprises a first small pulley (18) coaxially embedded in the output end of the driving motor (2), the side of the stirring box (1) is rotatably installed with a connecting shaft (20), the outer surface of the connecting shaft (20) is coaxially embedded with a second large pulley (22), the first small pulley (18) and the second large pulley (22) are connected with a first belt (19), the outer surface of the connecting shaft (20) is coaxially embedded with a second small pulley (21) near the side of the second large pulley (22), and the end of the reciprocating lead screw (4) is coaxially embedded with a first large pulley (9).

5. The device for producing raw drug of ramelteon according to claim 1, characterized in that: The component delivery element comprises three sub-hoppers (24) fixedly installed in linear array at the lower end of the base (8), the upper end of the sub-hopper (24) extends to the upper end surface of the base (8), the interior of the sub-hopper (24) is provided with two partitions (35), the rear end of the base (8) is elastically mounted with three push rods (26) in linear array, the lower end of the sub-hopper (24) is fittedly mounted with a discharge seat (37), the discharge seat (37) is fixed with the lower end of the push rod (26), the rear end upper edge of the three push rods (26) is extended with a push lug (30), the length of the three push lugs (30) increases in turn, the front end of the feeding hopper (5) is rotatably mounted with a push pawl (12), the bottom of the feeding hopper (5) is adapted to the sub-hopper (24).

6. A device for producing raw drug of Ramelteon according to claim 5, characterized in that: The outer surface of the lower part of the three push rods (26) is coaxially embedded with a connecting belt wheel (27), the connecting belt wheels (27) on the adjacent two push rods (26) are connected with a synchronous belt (25), the middle part of the push pawl (12) is rotatably mounted with an adaptive column (34), the outer surface of the adaptive column (34) is elastically mounted with an adaptive shell (33), the end of the adaptive shell (33) is rotatably connected with the feeding hopper (5), the middle part of the push rod (26) is rotatably mounted with an extension seat (28), the end of the extension seat (28) is fixed with the base (8), the side surface of the extension seat (28) is extended with a limiting frame (29), the end of the limiting frame (29) is on the push lug (30), the side surface of the feeding hopper (5) is fixedly mounted with a fixed pawl frame (36), the end of the fixed pawl frame (36) is on the push pawl (12).

7. A device for producing raw drug of Ramelteon according to claim 6, characterized in that: The upper part of the outer side of the push rod (26) is wound with a torsion spring (31), one end of the torsion spring (31) is fixed with the extension seat (28), the other end of the torsion spring (31) is fixed with the upper end of the push rod (26).

8. The device for producing raw drug of ramelteon according to claim 6, characterized in that: The end of the adaptive column (34) is coaxially embedded with a positioning cap (10), the positioning cap (10) is slidably installed in the interior of the adaptive shell (33), the end of the positioning cap (10) is fixedly mounted with a spring body (32), the end of the spring body (32) is fixed with the rear end of the interior of the adaptive shell (33). The end of the adaptive column (34) is coaxially embedded with a positioning cap (10), the positioning cap (10) is slidably installed in the interior of the adaptive shell (33), the end of the positioning cap (10) is fixedly mounted with a spring body (32), the end of the spring body (32) is fixed with the rear end of the interior of the adaptive shell (33).

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