Composition for cardiovascular protection and immunoregulation and preparation method thereof

Abstract

The invention discloses a cardiovascular protection and immunoregulation composition and a preparation method thereof. The composition for cardiovascular protection and immunoregulation is prepared from a nattokinase component and an astragalus mongolicus extract component. Through the scheme, the health-care food achieves the auxiliary effects of protecting heart and blood vessel injury, regulating immune function and preventing hypertension, hyperlipidemia, diabetes and coronary heart disease.

Description

Technical Field

[0001] This invention relates to the field of medicine and health care, specifically to a composition for cardiovascular protection and immune regulation and its preparation method. Background Technology

[0002] Natto is a healthy food made from soybeans (Glycine max (L.) Merr.) that have been steamed and softened before being fermented with Bacillus subtilis natto. Natto is characterized by its sticky, viscous, stringy consistency, unique aroma, and savory, slightly spicy taste. It contains various bioactive components, including nattokinase, subtilisin, vitamin K2, polyglutamic acid, soy isoflavones, and 2,5-dimethylpyrazine. Nattokinase promotes the conversion of plasminogen to plasmin, enhancing fibrinolysis in the blood, thereby dissolving blood clots, preventing atherosclerosis, and reducing the risk of cardiovascular disease. It has a positive impact on the health of patients with hypertension, hyperlipidemia, diabetes, cardiovascular and cerebrovascular diseases, and those requiring health management.

[0003] Mongolian astragalus (Astragalus mongholicus Bunge) is the dried root of a legume belonging to the genus Astragalus, widely used in traditional Chinese medicine. It is believed to have functions such as tonifying qi and strengthening the exterior, enhancing immunity, combating fatigue, and assisting in the treatment of some chronic diseases. Native to northern China, it is mainly distributed in Hebei, Shanxi, Inner Mongolia, Liaoning, Jilin, and Heilongjiang provinces. The main active components of Mongolian astragalus include astragalus polysaccharides I, II, and III, astragaloside A, and verbascoside isoflavones. These active components help delay aging, enhance physical strength, and promote cell repair. It has an auxiliary conditioning effect on the health of people with weak physical strength, low immunity, and those seeking to combat fatigue. Summary of the Invention

[0004] (a) Technical problems to be solved This invention provides a composition for cardiovascular protection and immune regulation, and a method for preparing the same, which has protective effects on the heart and blood vessels as well as regulatory effects on immune function.

[0005] (II) Technical Solution The present invention provides the following technical solution: a composition for cardiovascular protection and immune regulation, comprising nattokinase and Astragalus membranaceus extract.

[0006] A composition for cardiovascular protection and immune regulation, comprising the following ingredients in parts by weight: 4 parts nattokinase and 1 part Astragalus membranaceus extract.

[0007] A composition for cardiovascular protection and immune regulation, comprising the following ingredients in parts by weight: 4 g of nattokinase and 1 g of Astragalus membranaceus extract.

[0008] A method for preparing a composition for cardiovascular protection and immune regulation includes the following steps: S1, material selection: Nattokinase component and Astragalus membranaceus extract component raw materials are subjected to strict quality inspection and screening to ensure compliance with production standards.

[0009] S2. Weigh an appropriate amount of natto raw material, wash it, and soak it in 3 times its volume of water. Then sterilize it at high temperature for 20 minutes. Then add natto starter culture and put it into a fermentation chamber for fermentation. Then dry it at low temperature to reduce the moisture content to below 5%. Then crush and filter it through a 30-40 mesh sieve to obtain natto components.

[0010] S3. Weigh the corresponding amount of Astragalus membranaceus component raw material, add 6-18 times the amount of water, and extract 3 times. Then combine the extracts, refine, and filter. Concentrate the filtrate under reduced pressure to a relative density of 1.12-1.26. Then vacuum dry and pulverize using an 80-100 mesh sieve to obtain the Astragalus membranaceus component, and mix it with the natto component and package it.

[0011] (III) Beneficial Effects Compared with the prior art, the present invention provides a composition for cardiovascular protection and immune regulation and its preparation method, which has the following beneficial effects: This cardiovascular protective and immune-regulating composition and its preparation method, when rationally combined, can help protect heart function and prevent vascular damage, and regulate the body's immune function.

[0012] This cardiovascular protective and immune-regulating composition and its preparation method, through the bioactive natto and Mongolian astragalus components, can reduce the occurrence of diseases such as hyperlipidemia, hyperglycemia, and coronary heart disease, and help reduce the risk of chronic diseases in users. Detailed Implementation

[0013] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. All embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the protection scope of the present invention.

[0014] Example 1

[0015] A composition for cardiovascular protection and immune regulation, comprising the following ingredients in parts by weight: 4 parts nattokinase and 1 part Astragalus membranaceus extract.

[0016] Example 2

[0017] A composition for cardiovascular protection and immune regulation, comprising the following ingredients in parts by weight: 4 grams of nattokinase and 1 gram of Astragalus membranaceus extract.

[0018] Natto is a healthy food made by steaming and softening soybeans (Glycine max (L.) Merr.) and then fermenting them with Bacillus subtilis natto. Natto contains a variety of bioactive components, including nattokinase, subtilisin, vitamin K2, polyglutamic acid, soy isoflavones, and 2,5-dimethylpyrazine.

[0019] Mongolian astragalus (Astragalus mongholicus Bunge) belongs to the genus Astragalus in the legume family. It has the effects of tonifying qi and strengthening the exterior, improving immunity, anti-fatigue, and assisting in the treatment of some chronic diseases. The roots of Mongolian astragalus are rich in bioactive components such as astragalus polysaccharides I, II, and III, astragaloside A, and verbascoside isoflavones.

[0020] A method for preparing a composition for cardiovascular protection and immune regulation, wherein the method for preparing the nattokinase component includes the following steps: S1, soybean acceptance: acceptance in accordance with soybean quality standards and grain hygiene standards.

[0021] S2. Wash and soak the soybeans. Transfer the washed soybeans to a soaking container and add water. The weight of the water should be about 3 times that of the soybeans.

[0022] S3. After soaking the soybeans, drain the wastewater, rinse them 1-2 times again, and then proceed to the steaming process. When the pressure inside the pot reaches 0.2±0.02Mpa and the temperature reaches 126±2℃, start the pressure holding time for 18-25 minutes.

[0023] S4. While steaming, disinfect the utensils with hot water above 85℃ and prepare the natto starter culture solution according to the ratio.

[0024] S5. The fermented natto semi-finished product is pushed into the cold storage room for low-temperature drying, so that the moisture content of the material is reduced to below 5% within 50-84 minutes. Then it is crushed to obtain natto components.

[0025] A method for preparing a composition for cardiovascular protection and immune regulation, wherein the preparation method of the Astragalus membranaceus extract component includes the following steps: S1, raw material acceptance according to the Astragalus membranaceus standard.

[0026] S2. Perform three water extractions: For the first extraction, add 6-18 times the amount of water as the feed, extract for 60-180 minutes at a temperature of 90-100℃; for the second extraction, add 6-14 times the amount of water as the feed, extract for 60-120 minutes at a temperature of 90-100℃; for the third extraction, add 6-12 times the amount of water as the feed, extract for 60-90 minutes at a temperature of 90-100℃, and combine the extracts.

[0027] S3. Then refine and filter. Concentrate the filtrate under reduced pressure (temperature 55-85℃, vacuum -0.02 to -0.08Mpa) to a relative density of 1.12-1.26 (temperature 55-85℃). Add the extract and refine again.

[0028] S4. Perform vacuum drying (temperature 55~95℃, vacuum -0.02~ -0.09Mpa) and spray drying (inlet air temperature 85-185℃, outlet air temperature 65-85℃). After drying, pulverize the Astragalus powder (Astragalus extract powder) through an 80-100 mesh sieve to obtain Mongolian Astragalus component.

[0029] Example 3: Immunomodulatory effect of the composition of the present invention on Brucella infection.

[0030] Case 1: Patient Bao**, female, 50 years old, residing in Horqin Right Middle Banner, Hinggan League, Inner Mongolia. Outpatient serum Brucella antibody testing results showed strongly positive (++++) results for Brucella disease assays (tube coagulant 1:25), (tube coagulant 1:50), (tube coagulant 1:100), and (tube coagulant 1:200). After 40 days of taking the composition of this invention, all Brucella antibody test results turned negative (-).

[0031] Case 2: Patient Xiang*, female, 42 years old, residing in Zhalute Banner, Tongliao City, Inner Mongolia. Outpatient serum Brucella antibody testing results showed strongly positive (++++) results for Brucella disease assays (tube coagulant 1:25), (tube coagulant 1:50), (tube coagulant 1:100), and (tube coagulant 1:200). After taking the composition of this invention for 30 days, all Brucella antibody test results turned negative (-).

[0032] Example 4: Effects of the composition of the present invention on carotid artery plaques and thyroid nodules.

[0033] Case 1: Patient Sai***, male, 68 years old, residing in Keerqin District, Tongliao City, Inner Mongolia. Outpatient examination revealed multiple lipid plaques in both carotid arteries, the largest measuring 14.6 mm in length. He also presented with multiple cystic nodules and hypoechoic nodules in the thyroid gland, the largest measuring 3.1*1.8 cm. After taking the composition of this invention for 60 days, the largest carotid artery lipid plaque shrank to 7.6 mm, and the thyroid nodules also shrank.

[0034] Example 5: The regulatory effect of the composition of the present invention on hyperlipidemia.

[0035] Case 1: Patient Wu***, male, 45 years old, residing in Dongsheng District, Ordos City, Inner Mongolia. His outpatient serum tests showed elevated total cholesterol and low-density lipoprotein levels, at 6.02 mmol / L and 3.54 mmol / L, respectively. After taking the composition of this invention for 20 days, his serum total cholesterol decreased to 5.57 mmol / L, and his low-density lipoprotein level returned to normal.

[0036] The present invention can be effectively implemented by following the above embodiments. For those skilled in the art, any unsubstantiated modifications or embellishments made without departing from the principles of the present invention are still within the protection scope of the present invention.

Claims

1. A composition for cardiovascular protection and immunomodulation, characterized in that, It is composed of natto kinase and mongolian astragalus extract.

2. A composition for cardioprotection and immunomodulation according to claim 1, characterized in that, The weight parts of the natto kinase component and the mongolian astragalus extract component are: natto kinase 4 parts, mongolian astragalus extract 1 part.

3. The composition for cardioprotection and immunomodulation according to claim 1, wherein The mass fractions of the natto kinase component and the mongolian astragalus extract component are: natto kinase 4 grams, mongolian astragalus extract 1 gram.

4. A process for the preparation of a composition for cardiovascular protection and immunomodulation according to claims 1-4, characterized by, It comprises the following steps: S1, material selection: the natto kinase component and the mongolian astragalus extract component raw materials of claims 1-4 are subjected to strict quality inspection and screening to ensure compliance with production standards. S2, an appropriate amount of natto raw material is weighed, washed, and then soaked in 3 times the volume of water, followed by high-temperature sterilization for 20 minutes. Then, natto dry bacteria are added and placed in a fermentation box for fermentation, followed by low-temperature drying treatment to reduce the water content to below 5%, then crushed and processed using a 30-40 mesh screen and filtered to obtain the natto component. S3, the corresponding amount of mongolian astragalus component raw material is weighed, 6-18 times the amount of water is added, and extracted 3 times. Then, the extract is combined, refined, and filtered, and the filtrate is reduced pressure concentrated to a relative density of 1.12-1.

26. Then, vacuum drying is performed, and the product is crushed using an 80-100 mesh screen to obtain the mongolian astragalus extract component, which is then mixed with the natto component and packaged.