A double-layer guided bone regeneration membrane and a preparation method thereof
By using a double-layered guided bone regeneration membrane, the dense layer blocks fibroblasts while the porous layer supports bone cell growth, thus solving the problems of weak mechanical strength, rapid degradation, and poor antibacterial effect of existing membranes, and achieving a bone regeneration effect with moderate strength and matched degradation.
CN121754741BActive Publication Date: 2026-06-02SICHUAN UNIV
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SICHUAN UNIV
- Filing Date
- 2026-03-05
- Publication Date
- 2026-06-02
Smart Images
Figure CN121754741B_ABST
Abstract
The application provides a double-layer guided bone regeneration membrane and a preparation method thereof, relates to the technical field of bone regeneration, and is composed of a compact layer and a porous layer which are arranged in a top-bottom stack, wherein the compact layer is prepared by cross-linking and modifying soluble eggshell membrane protein (SEP), epigallocatechin gallate (EGCG) and carboxymethyl chitosan (CMC) through genipin, has a compact non-porous structure and is used for blocking the migration of soft tissue cells; the porous layer is obtained by cross-linking hydroxyapatite modified by 3-aminopropyl triethoxysilane (APTES) and carboxymethyl chitosan (CMC) through genipin, has a three-dimensional porous structure and is used for promoting the growth of bone cells and bone regeneration. The double-layer guided bone regeneration membrane has good tensile strength, physical barrier function, antibacterial performance and controllable degradation, and can realize safe and effective bone formation effect under the irradiation of 808nm near-infrared light and 1W power.
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