Portable oxygen supply device and method for organ perfusion transfer

Abstract

The invention relates to the technical field of organ preservation, in particular to a portable oxygen supply device and method for organ perfusion and transfer. The module comprises a portable oxygen generator, an air-oxygen mixer, a gas supercharging device and a control unit. High-concentration oxygen is generated through the oxygen generator, the high-concentration oxygen is mixed with ambient air according to needs through the air-oxygen mixer, and then the mixture is pressurized and conveyed to the membrane type oxygenator. According to the invention, a high-pressure gas cylinder is abandoned, and the problems of transportation limitation, poor portability, logistics dependence and the like are solved. A degradation working mode and safety redundancy are innovatively introduced, when the main oxygen generation system breaks down, the system can be automatically switched to ambient air for oxygen supply, and the reliability of the system is greatly improved. Meanwhile, an intelligent closed-loop control function based on metabolic feedback is achieved, and gas parameters can be dynamically adjusted to optimize the organ maintenance state. The safe, portable, intelligent and efficient oxygen supply source is realized, and the efficiency of organ transplantation and transfer is greatly improved.

Description

Technical Field

[0001] This invention relates to the field of organ preservation technology, and more specifically to a portable oxygen supply device and method for organ perfusion transport. Background Technology

[0002] Organ transplantation is the core treatment for end-stage organ failure. To prolong the survival time of ex vivo organs and improve transplant outcomes, warm-blood mechanical perfusion transport systems have become a key supporting technology for organ transplantation, including the heart, liver, and kidneys. This system continuously infuses oxygenated warm-blood perfusion fluid, simulating the physiological environment to maintain organ metabolic activity.

[0003] Current technologies generally rely on premixed high-pressure compressed gas cylinders as the oxygenation gas source. This approach has significant drawbacks: ① Severely restricted transportation: High-pressure compressed gas cylinders are hazardous materials, and transportation channels are strictly controlled, severely limiting the organ acquisition radius and reducing distribution efficiency; ② Insufficient portability: The steel cylinders are heavy, significantly increasing the weight of the transport system and hindering rapid response and mobile operations; ③ Strong supply chain dependence: Specific ratio cylinders need to be pre-ordered, making it difficult to flexibly handle emergency transport or long-distance missions, and posing a risk of supply disruption.

[0004] Chinese patent application CN202080000700.4 discloses a portable oxygen generator, including at least one separation mechanism and an oxygen storage tank. The separation mechanism is connected to the oxygen storage tank. The separation mechanism includes an air bladder and a molecular sieve tank. The molecular sieve tank is filled with molecular sieves for adsorption. The air bladder has an air inlet and an air outlet. The valve group includes a first single valve and a second single valve. The air bladder is connected to the molecular sieve tank through the first single valve. The molecular sieve tank has at least one air outlet at each end. The air outlet connected to the air bladder has a second single valve, and the air outlet at the other end is connected to the oxygen storage tank. Each compression and expansion of the internal space of the air bladder corresponds to one adsorption and desorption cycle of the molecular sieves in the molecular sieve tank. The advantages of this invention are: low noise, low heat generation, and simple structure; the working stroke of the air bladder synchronizes the working process of the molecular sieve, eliminating the need for corresponding electronic sensors, microcontrollers, multi-channel solenoid valves, and complex control circuits in traditional devices; the air bladder can be manually compressed and expanded, and it can operate without power under special conditions.

[0005] While the relevant patented technologies have solved the transportation bottleneck caused by the reliance on high-pressure gas cylinders in organ transport through oxygen generators, some technical problems still need to be addressed in practical applications. Specifically, in existing molecular sieve oxygen generators, the molecular sieve particles inside have a uniform microporous structure, and these micropores can adsorb gas molecules according to their size and shape. During the oxygen generation process, molecules such as nitrogen and oxygen in the air are adsorbed onto the surface of the molecular sieve particles. Because nitrogen molecules are more easily captured by the molecular sieve particles inside the oxygen generator, oxygen and nitrogen are separated.

[0006] During the operation of an oxygen generator, the gas separation process exhibits periodic dynamic characteristics. Specifically, within each complete working cycle, the pressure changes within the molecular sieve cylinder follow a specific pattern: first, a pressurization phase with increasing pressure; then, a constant-pressure working phase with stable pressure; and finally, a regeneration phase with decreasing pressure. This periodic pressure fluctuation causes continuous changes in the pressure value within the cylinder, and the rate of pressure change varies significantly across different phases. The periodic changes in the inter-particle spacing caused by these pressure fluctuations lead to non-uniform mechanical friction between the particles, which, over long-term operation, will cause pulverization of the molecular sieve material.

[0007] From the perspective of adsorption kinetics, the performance optimization of molecular sieve oxygen generators depends on appropriate mechanical compression. Under pressurized conditions, the mean free path of gas molecules shortens, the diffusion rate accelerates, and the adsorption efficiency of the molecular sieve pore structure is significantly improved. Experimental data shows that pressure parameters are positively correlated with adsorption capacity, and appropriately increasing the system pressure can effectively enhance oxygen and nitrogen separation. However, the spring-permeable plate compression mechanism commonly used in current equipment has structural defects: limited by the elastic limit and geometry of the spring material, its working stroke range is limited. Specifically, when irreversible volume shrinkage occurs due to long-term use of the molecular sieve, traditional compression devices cannot provide sufficient compensating pressure through elastic deformation, ultimately leading to a decrease in the contact quality of the adsorption interface and a reduction in separation efficiency. Summary of the Invention

[0008] The purpose of this invention is to provide a portable oxygen supply device and method for organ perfusion transport, aiming to solve the problems mentioned in the background art.

[0009] To achieve the above objectives, the present invention provides the following technical solution: A portable oxygen supply device for organ perfusion transport, comprising: The oxygen generation unit is used to separate and produce high concentrations of oxygen from ambient air; An air-oxygen mixing unit has a first inlet connected to the output of the oxygen generating unit and a second inlet connected to ambient air, used to mix high-concentration oxygen with ambient air in a proportional manner. The gas pressurization unit, whose inlet is connected to the outlet of the air-oxygen mixer unit, is used to pressurize the mixed gas to the working pressure required by the organ perfusion system. The control unit, which is electrically connected to the air-oxygen mixer unit, is used to receive the target oxygen concentration set value and control the mixing ratio of the air-oxygen mixer unit so that the oxygen concentration of the output gas is stabilized at the set value. The control unit has built-in degraded operating mode control logic. When the oxygen generating unit fails, it controls the air-oxygen mixer unit to close its first inlet and fully open its second inlet, so that the system outputs filtered ambient air.

[0010] Preferably, the control unit receives real-time metabolic parameters from the organ perfusion system through a data communication interface and can dynamically adjust the target oxygen concentration setpoint of the air-oxygen mixer unit based on these metabolic parameters.

[0011] Preferably, the oxygen generating unit comprises: Molecular sieve, comprising a gas collecting cylinder, wherein both sides of the gas collecting cylinder are provided with gas inlets, and each gas inlet is provided with a gas inlet and a nitrogen outlet. The gas delivery unit has its output end connected to a first guide pipe and a second guide pipe via a branch tee, and the first guide pipe and the second guide pipe are respectively connected to the air inlets of the air inlets on both sides of the gas collecting cylinder. The nitrogen venting section is connected to a first regulating pipe and a second regulating pipe via a nitrogen venting tee. The first regulating pipe and the second regulating pipe are respectively connected to the nitrogen venting ports of the air inlets on both sides of the gas collecting cylinder.

[0012] Preferably, the air inlets distributed at both ends of the air collecting cylinder are connected to the air collecting cylinder through air outlets, and the air outlets are located at the bottom of the air collecting cylinder; The air intake cylinder is filled with oxygen-generating particles, and a collector is provided on the outside of the air intake cylinder for collecting the pulverized oxygen-generating particles.

[0013] Preferably, the collecting component includes a powder-permeable section disposed on the outside of the air inlet cylinder, and a powder box is provided below the powder-permeable section for collecting pulverized oxygen-generating particles.

[0014] Preferably, the air inlet cylinder is provided with a clamping component for compressing the oxygen-generating particles, the clamping component comprising: A vent plate is installed inside the air intake cylinder and can move axially along the air intake cylinder; The elastic part has one end connected to the vent plate and the other end connected to one end of the air inlet and air collection cylinder.

[0015] Preferably, the powder box is provided with a pressure regulating component, the pressure regulating component comprising: The receiving part is located inside the toner cartridge and can move axially along the toner cartridge; The pressure-bearing part has one end connected to the receiving part and the other end connected to the powder box; The air duct is equipped with a one-way valve, one end of which is connected to the pressure receiving part, and the other end is connected to the clamping part.

[0016] Preferably, the air intake cylinder has a follower component inside, the follower component comprising: The extrusion section has one end connected to the vent plate and the other end connected to the end of the air inlet cylinder facing the air collection cylinder; The telescopic section is located between the receiving section and the powder-permeating section, and is connected to the extrusion section via a connecting pipe.

[0017] Preferably, the end of the air inlet cylinder away from the air collecting cylinder is provided with a cover that communicates with the elastic part, and the cover covers the air inlet and the air outlet.

[0018] The present invention also provides an oxygen supply method for supplying oxygen to donor organs using a portable oxygen supply device, the oxygen supply method comprising the following steps: S1. Start the oxygen generation unit. The oxygen generation unit produces high-concentration oxygen through molecular sieve. S2. The air-oxygen mixing unit automatically draws in filtered ambient air according to the set parameters and mixes it with high-concentration oxygen in a precise ratio. S3. The mixed gas is pressurized to the set pressure by the gas pressurization unit, and then the output flow rate is adjusted by the scavenging flow rate control unit, so that the oxygenated gas that meets the requirements is finally delivered to the organ perfusion system.

[0019] The technical effects and advantages of this invention are as follows: 1. This invention optimizes the air intake structure by adding a collection component to the outside of the air intake. Through the coordinated mechanism of the powder-permeable section and the powder box, it can efficiently collect oxygen-generating particles that have become powdery during use. This design effectively prevents powdery particles from clogging the gaps between the oxygen-generating particles, avoiding obstruction that could hinder gas entry into the oxygen-generating particle layer and thus prevent powder spraying. This strongly ensures the stable and efficient operation of the oxygen generation process.

[0020] 2. This invention incorporates a clamping component, in which an elastic part is connected to a permeable plate. During operation of the oxygen generator, the elastic part pushes the permeable plate to apply appropriate clamping force to the oxygen particles. This design prevents insufficient clamping force from causing friction and wear between oxygen particles, which could exacerbate pulverization and effectively extend the service life of the oxygen particles, thus improving oxygen generation efficiency. Furthermore, when pulverization occurs, the elastic part pushes the permeable plate to move, which in turn activates the follower and pressure adjustment components. Through this series of interconnected actions, the pressure loss caused by prolonged use of the elastic part is compensated, maintaining its original clamping performance and ensuring that the oxygen particles are always tightly packed, further improving oxygen generation efficiency. Simultaneously, it prevents pulverized particles from escaping, ensuring the reliability and stability of the oxygen generator. Attached Figure Description

[0021] Figure 1 This is a schematic diagram of the main frame of the oxygen supply system of the present invention; Figure 2 This is a schematic diagram of the main frame of the organ perfusion system of the present invention; Figure 3 This is a schematic diagram of the main frame of the oxygen generation unit of the present invention; Figure 4 This is a schematic diagram of the structure of the molecular sieve of this invention; Figure 5 This is a schematic diagram of the internal structure of the molecular sieve of the present invention; Figure 6 For the present invention Figure 5 A magnified view of a portion of point A in the middle; Figure 7 This is a schematic diagram of the cross-sectional structure of the molecular sieve of the present invention.

[0022] In the picture: 1. Molecular sieve; 101. Inlet cylinder; 102. Gas collection cylinder; 2. Clamping component; 201. Elastic part; 202. Ventilation plate; 3. Collection component; 301. Toner box; 302. Translucent powder section; 4. Pressure-bearing adjustment component; 401. Receiving part; 402. Pressure-bearing part; 403. Air guide pipe; 5. Follower component; 501. Extrusion section; 502. Connecting pipe; 503. Telescopic section; 6. Vent section; 7. Gas transmission section; 8. Nitrogen removal section; 9. Air intake; 10. Nitrogen vent; 11. Cover body. Detailed Implementation

[0023] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention. Example

[0024] Reference Figures 1 to 7 This invention provides a portable oxygen supply device for organ perfusion transport. The device mainly consists of an oxygen generation unit, an air-oxygen mixing unit, a gas pressurization unit, a control unit, a sweep gas flow rate control unit, and a data communication interface. The various units work together to achieve efficient and stable oxygen supply.

[0025] The oxygen generation unit, as one of the core components of this device, is responsible for separating and producing high-concentration oxygen from ambient air. Specifically, this unit employs molecular sieve 1 technology, which uses the adsorption effect of molecular sieve 1 to separate and concentrate oxygen from the ambient air, thereby producing an oxygen stream with a stable concentration between 90% and 95%. To ensure the cleanliness and sterility of the output gas, the oxygen generation unit is also equipped with an intake filter and a bacterial filter, effectively filtering out impurities and microorganisms in the air.

[0026] The air-oxygen mixing unit is responsible for mixing the high-concentration oxygen generated by the oxygen generator with ambient air in a specific ratio. This unit is a medical-grade, high-precision gas mixing device with two inlets and one outlet. The first inlet connects to the output of the oxygen generator to receive the high-concentration oxygen; the second inlet is directly connected to the ambient air and is equipped with an air filter to remove impurities. The core function of the air-oxygen mixing unit is its ability to precisely mix high-concentration oxygen with ambient air according to a preset volume ratio to meet the needs of different clinical scenarios.

[0027] The gas pressurization unit is connected to the outlet of the air-oxygen mixing unit, and its function is to pressurize the mixed low-pressure gas to the working pressure required by the organ perfusion system. To achieve this function, the gas pressurization unit can use high-efficiency pressurization equipment such as a miniature diaphragm compressor or a scroll compressor.

[0028] The control unit is electrically connected to the air-oxygen mixing unit and is responsible for receiving the user-set target oxygen concentration (FiO2) value. It dynamically adjusts the mixing ratio of high-concentration oxygen with ambient air by controlling the proportional valve or venturi device inside the air-oxygen mixer. The control unit includes an integrated microprocessor, sensors, and a display input interface, enabling real-time monitoring and adjustment of the output gas oxygen concentration to ensure its stability at the set value. Furthermore, the control unit receives real-time metabolic parameters from the organ perfusion system via a data communication interface, such as the partial pressure of oxygen (pO2), partial pressure of carbon dioxide (pCO2), and pH value of the perfusion fluid. Based on these parameters, it dynamically adjusts the target oxygen concentration setpoint of the air-oxygen mixing unit to achieve more precise oxygen supply control.

[0029] To meet the needs of different clinical scenarios, the control unit also presets several one-button perfusion modes, such as "standard perfusion mode" (automatically setting FiO2 to 85%) and "hyperoxygen perfusion mode" (FiO2 to 95%). These modes can be quickly switched according to actual needs, improving the flexibility and ease of use of the device. Simultaneously, the control unit also incorporates degraded operating mode control logic. When a fault is detected in the oxygen generation unit, the control unit can automatically or manually trigger this mode, closing the high-concentration oxygen inlet and fully opening the ambient air inlet, allowing the system to pressurize and output filtered ambient air to provide basic oxygen supply to organs. This design ensures the safety and reliability of the device in fault conditions.

[0030] The scavenging gas flow rate control unit, located in the gas output path, is a high-precision gas flow rate regulating valve. Its main function is to control the flow rate of scavenging gas entering the oxygenator to maintain the partial pressure of carbon dioxide in the perfusion fluid within the physiologically permissible range. Precise adjustment of the scavenging gas flow rate ensures stable gas exchange within the oxygenator, thereby safeguarding the normal physiological function of the organs.

[0031] The data communication interface serves as a crucial bridge for data exchange between this device and external equipment. This interface can exchange data with the organ perfusion system host, receiving real-time metabolic parameters from the host. These parameters not only provide the control unit with a basis for adjusting oxygen supply strategies but can also be used to monitor the physiological state of organs and assess treatment effectiveness.

[0032] During implementation, the operator first places the oxygen generator unit next to the organ perfusion system main unit and connects the power. Then, the output gas pipeline is connected to the air inlet 9 of the membrane oxygenator in the organ perfusion system via a quick-connect interface. After turning on the main switch, the control unit starts up and enters standby mode. The user can select the desired perfusion mode, such as "standard perfusion mode," via the touchscreen. The control unit then starts the portable oxygen generator unit and the gas pressurization unit to begin the oxygen supply process. After a short startup time, the oxygen generator unit outputs oxygen at a concentration of 93% ± 2% and delivers it to the oxygen inlet of the air-oxygen mixing unit. Simultaneously, the air-oxygen mixing unit, according to the received FiO2 setting command, draws in filtered ambient air from the air inlet at a precise ratio through its internal proportional valve. Inside the air-oxygen mixer, the high-concentration oxygen mixes thoroughly with the ambient air to form a mixed gas of the desired composition. This mixed gas is then pressurized to approximately 300 mmHg by a miniature diaphragm compressor and stably delivered to the membrane oxygenator in the organ perfusion system via pipeline. Inside a membrane oxygenator, the mixed gas undergoes thorough oxygenation and CO2 exchange with the blood, providing continuous life support to the donor heart. Organ perfusion systems are existing technology and will not be discussed further here.

[0033] The control unit of this invention also features a closed-loop control algorithm. During operation, the algorithm receives real-time perfusion fluid oxygen partial pressure (pO2) data from the organ perfusion system's main monitoring module via a data communication interface. The control unit compares and analyzes the received pO2 value with the user-defined ideal target range. If the pO2 remains below the target range, the control algorithm automatically fine-tunes and increases the FiO2 setting of the air-oxygen mixing unit; conversely, it appropriately decreases the FiO2. This process forms a closed-loop feedback mechanism, ensuring that the perfusion fluid oxygenation level remains stable at the optimal state without frequent manual intervention, thus improving the accuracy and stability of oxygen supply.

[0034] In addition, the control unit continuously monitors the operating status and output concentration of the oxygen generator unit. If a malfunction or abnormal output concentration is detected, the touchscreen will immediately issue an audible and visual alarm and prompt the user to "Activate degraded mode?". Upon user confirmation, the control unit will execute the degraded mode procedure, shutting off the power to the oxygen generator unit and actuating the valves inside the air-oxygen mixer unit to completely close the high-concentration oxygen inlet while ensuring the ambient air inlet remains fully open. Subsequently, the system only pressurizes and outputs filtered ambient air. Although the oxygen concentration drops to 21%, it can still provide basic life support for the donor heart, buying at least 1 to 2 hours of valuable time for subsequent treatment. This design fully demonstrates the safety and reliability of the invention.

[0035] The entire oxygen supply module is integrated within the organ transport device, making it easy to carry and move. The module can be powered by a built-in battery pack or an external universal power adapter to meet the needs of different scenarios. In practical applications, the portable oxygen supply device provided by this invention has demonstrated its excellent performance and stability, making a positive contribution to the development of the organ perfusion transport field. Example

[0036] Although the oxygen concentrators used in the aforementioned embodiments effectively solved the transportation bottleneck problem caused by reliance on high-pressure gas cylinders during organ transport, some technical challenges still need to be overcome in practical applications. Specifically, during the continuous operation of the oxygen concentrator, the gas inside molecular sieve 1 exhibits periodic pressure fluctuations. These pressure fluctuations further cause periodic changes in the gaps between oxygen-generating particles in molecular sieve 1, resulting in uneven mechanical friction between the particles. Under this operating condition for a long time, the molecular sieve 1 material will gradually pulverize. More problematic is that existing technology cannot effectively collect the pulverized oxygen-generating particles during long-term operation of the oxygen concentrator. Therefore, with the extension of usage time, the oxygen concentrator will experience a "powder spraying" problem in the later stages of operation, i.e., pulverized particles are sprayed out with the gas. In view of this, a technical improvement is made based on embodiment one, and the improved technical solution is as follows: Reference Figures 1 to 7 The present invention provides a portable oxygen supply device for organ perfusion transport, including an oxygen generation unit, the oxygen generation unit including a molecular sieve 1, the molecular sieve 1 including a gas collecting cylinder 102, and air inlets 101 on both sides of the gas collecting cylinder 102, and air inlets 9 and nitrogen discharge ports 10 on the air inlets 101. The oxygen generation unit also includes a gas delivery section 7. The output end of the gas delivery section 7 is connected to a first guide pipe and a second guide pipe through a branch tee. The first guide pipe and the second guide pipe are respectively connected to the air inlets 9 of the air inlets 101 on both sides of the gas collection cylinder 102. The gas delivery section 7 includes an air pump. The air inlet end of the gas delivery section 7 is equipped with a filter screen to filter the ambient air and prevent external dust or oil from entering the air inlet 101 through the first guide pipe or the second guide pipe.

[0037] The oxygen generation unit also includes a nitrogen venting section 8, which is connected to a first regulating pipe and a second regulating pipe via a nitrogen venting tee. The first regulating pipe and the second regulating pipe are respectively connected to the nitrogen venting ports 10 of the air inlets 101 on both sides of the gas collecting cylinder 102.

[0038] In use, the air inlets 101 located on both sides of the air collecting cylinder 102 operate in an alternating manner. Specifically, both the first and second guide pipes are equipped with solenoid valves, and the alternating operation of the air inlets 101 is achieved by controlling the opening and closing of the solenoid valves. Both the first and second regulating pipes are equipped with regulating valves, and the nitrogen purging operation of the air inlets 101 is achieved by controlling the opening and closing of the regulating valves.

[0039] The air inlet cylinders 101 distributed at both ends of the air collecting cylinder 102 are connected to the air collecting cylinder 102 through the air outlet 6, and the air outlet 6 is located at the bottom of the air collecting cylinder 102. The air outlet 6 includes a filter screen, which is used to isolate pulverized particles and prevent them from entering the air collection cylinder 102 from the air outlet 6.

[0040] The air intake cylinder 101 is filled with oxygen-generating particles, and a collector 3 is provided on the outside of the air intake cylinder 101. The collector 3 is used to collect the pulverized oxygen-generating particles.

[0041] The collection component 3 includes a powder-permeable section 302 disposed on the outside of the air inlet cylinder 101, and a powder box 301 disposed below the powder-permeable section 302. The powder box 301 is used to collect pulverized oxygen-generating particles.

[0042] The powder permeation section 302 includes a filter screen. The mesh size of the powder permeation section 302 is smaller than the diameter of the oxygen-generating particles, but larger than the mesh size of the air outlet section 6.

[0043] The powder box 301 includes a box body that is closed at the bottom and around the perimeter. The box body is threadedly connected to the air inlet cylinder 101. By removing the box body from the air inlet cylinder 101, the powdered oxygen-generating particles can be cleaned.

[0044] The air inlet cylinder 101 is provided with a pressing component 2 for pressing the oxygen-generating particles. The pressing component 2 includes a permeable plate 202, which is disposed inside the air inlet cylinder 101 and can move axially along the air inlet cylinder 101. The clamping component 2 also includes an elastic part 201, one end of which is connected to the vent plate 202, and the other end is connected to one end of the air inlet cylinder 101 and the air collection cylinder 102.

[0045] Reference Figure 7 As shown, in this embodiment, the air inlet cylinders 101 at both ends of the air collecting cylinder 102 are respectively designated as cylinder A and cylinder B, and cylinder A and cylinder B work alternately during use.

[0046] In the initial state, the solenoid valves configured on the first guide tube and the second guide tube are both in the closed state.

[0047] During operation, the control unit activates the gas delivery unit 7 and simultaneously controls the solenoid valve connected to the first guide pipe to open. After the gas delivery unit 7 is activated, ambient air is delivered to the interior of cylinder A via the first guide pipe. The ambient air entering cylinder A first passes through the vent plate 202, and then enters the area between the vent plate 202 and the air inlet cylinder 101 filled with oxygen-generating particles, where oxygen generation is carried out. Specifically, when the ambient air comes into contact with the oxygen-generating particles, the particles intercept nitrogen and water molecules in the air, allowing only oxygen molecules to pass through, thereby achieving oxygen separation and enrichment. After the oxygen generation is completed, the oxygen enters the gas collection cylinder 102 through the gas outlet 6, and then is delivered to the membrane oxygenator of the organ perfusion system via the delivery pipe on the gas collection cylinder 102, where it is oxygenated with the perfusion fluid to meet the oxygen requirements of organ perfusion.

[0048] Furthermore, when ambient air enters the area filled with oxygen-generating particles through the vent plate 202, a certain pressure is generated in the cavity between the vent plate 202 and the air inlet 9. This pressure acts on the vent plate 202, pushing it towards the oxygen-generating particles, thereby enhancing the compression effect of the vent plate 202 on the oxygen-generating particles. This design can effectively avoid the situation where the compression force of the clamping component 2 on the oxygen-generating particles is insufficient, leading to mutual wear and accelerated pulverization between particles, thus extending the service life of the oxygen-generating particles and improving oxygen production efficiency.

[0049] In this embodiment, the position and angle of the air inlet 9 have been optimized. Specifically, the air inlet 9 is designed so that after the ambient air enters the air inlet cylinder 101 through the air inlet 9, it can flow as far as possible toward the powder permeation section 302. Subsequently, the air enters the air collection cylinder 102 through the air outlet 6.

[0050] It is particularly important to note that in this embodiment, the air inlet 9 is positioned higher than the air outlet 6. This arrangement causes the ambient air to naturally flow downwards when entering the air inlet 101 from the air inlet 9. During this downward flow, the airflow pushes the pulverized oxygen particles towards the powder permeation section 302, ultimately allowing them to enter the powder box 301. The powder box 301 is designed as a sealed box with a closed bottom and sides, effectively collecting the pulverized oxygen particles and preventing them from clogging the gaps between the particles. If the pulverized particles clog the gaps, the gas will encounter excessive resistance when entering the oxygen particle layer, potentially leading to powder spraying. Simultaneously, due to the sealed design of the powder box 301, the airflow towards the powder permeation section 302 will not exit the air inlet 101 from the powder box 301, but will still follow the designed path from the air outlet 6 into the air collection box 102, thus ensuring the stability and efficiency of the oxygen production process.

[0051] Furthermore, in the preferred embodiment, the air inlet 9 is not only positioned higher than the air outlet 6, but the angle between the air inlet 9 and the air collection cylinder 102 is designed to be an acute angle. This design allows the ambient air entering the air inlet cylinder 101 from the air inlet 9 to flow better toward the powder permeation section 302, further optimizing the airflow path and improving oxygen production efficiency and particle collection effect. Example

[0052] Although the aforementioned embodiments can effectively collect pulverized oxygen particles, considering that the airflow ultimately needs to enter the gas collection cylinder 102 through the outlet 6, even with a filter screen installed at the outlet 6 to block pulverized particles, these particles will gradually accumulate on the filter screen surface and clog the mesh during long-term operation. This phenomenon will directly lead to a continuous decrease in the oxygen flux entering the gas collection cylinder 102 through the outlet 6, thus making it impossible to stably maintain the oxygen supply required for subsequent perfusion of the donor organ. Therefore, a technical improvement is made based on Embodiment 2, and the improved technical solution is as follows: Reference Figures 1 to 7 This invention provides a portable oxygen supply device for organ perfusion transport, wherein the air outlets 6 located on the two air inlets 101 are arranged in a mirror image, specifically as follows: Figure 7 As shown.

[0053] In the specific application of this embodiment, the delivery pipe on the gas collecting cylinder 102 is equipped with an oxygen concentration sensor. The function of this oxygen concentration sensor is to detect the oxygen concentration value in the delivery pipe in real time. By analyzing this value, it is possible to accurately determine whether the adsorption of nitrogen by the air inlet cylinder 101 has reached a saturation state, and then adjust the working state of the two air inlet cylinders 101 accordingly based on the judgment result.

[0054] When cylinder A is in operation, the oxygen concentration sensor on the delivery pipe continuously monitors the oxygen concentration. If the detected oxygen concentration is below a preset range, it indicates that cylinder A has reached nitrogen adsorption saturation. At this point, the control unit responds quickly, closing the solenoid valve on the first guide pipe connected to cylinder A and simultaneously opening the solenoid valve on the second guide pipe connected to cylinder B. Simultaneously, the control unit also opens the regulating valve on the first regulating pipe connected to cylinder A.

[0055] After the solenoid valve and regulating valve are adjusted, the gas supply unit 7 begins to supply ambient air into cylinder B through the second guide pipe. Cylinder B contains oxygen-generating particles, which generate oxygen from the incoming ambient air. The oxygen produced during this process enters the gas collecting cylinder 102 through the outlet 6 on cylinder B. Of the oxygen entering cylinder 102, some is discharged through the gas supply pipe, while the remaining oxygen enters cylinder A through the outlet 6 on cylinder A. The oxygen entering cylinder A then discharges the nitrogen adsorbed inside cylinder A into the nitrogen venting unit 8 through the first regulating pipe, thus achieving nitrogen removal.

[0056] It should be noted that: the first regulating pipe and the second regulating pipe are equipped with nitrogen detection sensors at the end near the nitrogen discharge section 8. By detecting the nitrogen concentration, the degree of nitrogen discharge inside the air inlet cylinder 101 is determined, thereby controlling the opening and closing of the regulating valve.

[0057] As oxygen enters cylinder A through outlet 6, it creates a reverse impact on any pulverized particles that may be clogging outlet 6. This reverse impact forces the pulverized particles clogging outlet 6 back into the gaps between the oxygen-producing particles, ensuring unobstructed airflow from outlet 6 and preventing clogging by pulverized particles from affecting oxygen production and nitrogen removal efficiency. Simultaneously, when the control unit switches back to cylinder A to produce oxygen from the ambient air according to a preset program, the oxygen generated inside cylinder A pushes the pulverized particles back into the gaps between the oxygen-producing particles towards the powder permeation section 302, ultimately leading them into the powder box 301 for collection and processing.

[0058] It should be noted that, in this embodiment, to ensure that the oxygen exerts sufficient impact force on the outlet 6, thereby allowing the pulverized particles blocked at the outlet 6 to smoothly return to the gaps between the oxygen-generating particles, the pressure inside the gas collecting cylinder 102 can be adjusted in two ways. One way is to control the length and diameter of the gas collecting cylinder 102, thereby affecting its internal pressure by changing its geometric dimensions; the other way is to control the opening of the regulating valve on the gas delivery pipe of the gas collecting cylinder 102, thereby changing the gas flow rate and thus adjusting the pressure inside the gas collecting cylinder 102. The above methods for adjusting the internal pressure of the cylinder are all existing technologies in the art and will not be elaborated further here. Example

[0059] Although the aforementioned embodiments can effectively collect pulverized oxygen-generating particles, the collection of pulverized particles will increase the gaps between particles inside the cylinder. Although the elastic part 201 and the air pressure will compensate for the movement of the permeable plate 202, its working stroke range is limited by the elastic limit and geometric dimensions of the spring material. When the molecular sieve 1 undergoes irreversible volume shrinkage due to long-term use, the traditional pressing device cannot provide sufficient compensation pressure through elastic deformation, ultimately leading to a decrease in the contact quality of the adsorption interface and a reduction in separation efficiency. In view of this, a technical improvement is made based on Embodiment 2, and the improved technical solution is as follows: Reference Figures 1 to 7 The present invention provides a portable oxygen supply device for organ perfusion transport. The air inlet cylinder 101 is provided with a pressing member 2 for pressing the oxygen-generating particles. The pressing member 2 includes a vent plate 202, which is disposed inside the air inlet cylinder 101 and can move axially along the air inlet cylinder 101. The clamping component 2 also includes an elastic part 201, one end of which is connected to the vent plate 202, and the other end is connected to one end of the air inlet cylinder 101 or the air collection cylinder 102. The elastic part 201 includes a spring telescopic tube, which is connected to the cover body 11.

[0060] The powder box 301 is equipped with a pressure regulating component 4, which includes a receiving part 401. The receiving part 401 is located inside the powder box 301 and can move axially along the powder box 301. The receiving part 401 is connected to the powder box 301 through a pressure-receiving part 402. The pressure-receiving part 402 includes a spring telescopic tube and is located at the bottom of the receiving part 401. The receiving part 401 is connected to the cover 11 through a vent pipe 403. A one-way valve is provided on the vent pipe 403. The one-way valve only allows gas to enter the interior of the cover 11 through the vent pipe 403 and does not allow the gas inside the cover 11 to flow back.

[0061] The air inlet cylinder 101 is provided with a follower 5 inside. The follower 5 includes a compression part 501. One end of the compression part 501 is connected to the vent plate 202, and the other end is connected to the end of the air inlet cylinder 101 facing the air collection cylinder 102. The compression part 501 includes a piston cylinder.

[0062] The follower 5 also includes a telescopic part 503, which is disposed between the receiving part 401 and the powder-permeating part 302, and is connected to the extrusion part 501 through the connecting pipe 502. The telescopic part 503 includes an annular telescopic cylinder.

[0063] The end of the air inlet cylinder 101 away from the air collection cylinder 102 is provided with a cover 11 that is connected to the elastic part 201. The cover 11 covers the air inlet 9 and the exhaust port.

[0064] In a specific embodiment of the oxygen generator, the elastic part 201 is initially set to a compressed state. This design provides the basis for pressure regulation during the subsequent oxygen generation process.

[0065] When the oxygen-generating particles in the air inlet cylinder 101 begin to generate oxygen, the gas delivery section 7 introduces gas into the air inlet cylinder 101. This gas accumulates inside the air inlet cylinder 101, creating a relatively high pressure. This pressure exerts a squeezing effect on the receiving section 401 located in the powder box 301, causing the receiving section 401 to move downwards. The downward movement of the receiving section 401 has a dual function in the oxygen generating device.

[0066] Firstly, the downward shift of the receiving part 401 effectively increases the distance between the powder-permeating part 302 and the receiving part 401. This design takes into account the problem of powdered particle accumulation during oxygen production. If the distance between the receiving part 401 and the powder-permeating part 302 is too small, powdered particles are prone to excessive accumulation on the upper surface of the receiving part 401. This excessive accumulation will seriously affect the effective collection of powdered particles by the powder box 301 in subsequent operations, thus adversely affecting the overall performance of the oxygen production device. By increasing the distance between the two, this potential problem is avoided, ensuring the stable operation of the oxygen production device.

[0067] Secondly, during its downward movement, the receiving part 401 compresses the pressure-receiving part 402. After being compressed, the gas inside the pressure-receiving part 402 enters the interior of the cover 11 through the gas guide pipe 403. The cover 11, as a key component for gas distribution, evenly distributes the gas entering it into the interior of the elastic part 201. This process aims to compensate for pressure loss that may occur in the elastic part 201 during long-term use. Since the elastic part 201 is in a compressed state initially, its compressive performance may gradually weaken after prolonged use. Through gas compensation, the elastic part 201 can maintain its original compressive performance, thereby ensuring the compressive effect on the oxygen-generating particles, improving the oxygen-generating effect of the oxygen-generating particles, and ensuring the stable operation of the oxygen-generating device.

[0068] It is particularly important to note that a one-way valve is installed on the gas guide pipe 403. This one-way valve strictly restricts the gas flow direction, allowing gas only to enter the interior of the shroud 11 through the gas guide pipe 403 while preventing gas inside the shroud 11 from flowing back through the gas guide pipe 403. During alternating operation, the pressure-bearing part 402 may experience a reverse action due to restoring force. Without the one-way valve, gas inside the shroud 11 might flow back to the pressure-bearing part 402, causing the elastic part 201 to lose pressure compensation, thereby reducing the compression effect of the permeable plate 202 on the oxygen-generating particles. By setting up the one-way valve, this problem is effectively avoided, ensuring the stability of the oxygen generator during alternating operation.

[0069] Simultaneously, when the oxygen-generating particles pulverize during use, the inherent elastic restoring force of the elastic part 201 begins to function. Specifically, the elastic part 201 pushes the connected permeable plate 202 towards the gas collecting cylinder 102. During this movement, the permeable plate 202 applies a compressive force to the extrusion part 501. After being compressed by the permeable plate 202, the medium contained inside the extrusion part 501 (which can be gas or liquid) enters the telescopic part 503 between the receiving part 401 and the powder-permeating part 302 through the connecting pipe 502. As the medium continues to enter, the telescopic part 503 undergoes axial elongation.

[0070] Since the powder-permeable section 302 is fixedly connected to the air inlet cylinder 101, the powder-permeable section 302 remains stationary when the telescopic section 503 extends. The receiving section 401, however, will experience a further downward movement under the pushing action of the telescopic section 503. This design is crucial for the subsequent operation of the air inlet cylinder 101. When the oxygen-generating particles shrink due to use, the pressure on the elastic section 201 decreases accordingly. At this time, the further downward movement of the receiving section 401 allows the pressure-bearing section 402 to compensate for the pressure loss of the elastic section 201, thereby ensuring that the compression effect of the permeable plate 202 on the oxygen-generating particles is not affected.

[0071] Furthermore, although the amount of oxygen entering the air inlet cylinder 101 through the air outlet 6 is relatively small, a limiting member is provided inside the compression section 501 in this embodiment to prevent potential risks. This limiting member is designed to allow only the compression section 501 to contract and not extend. The limiting member can be a wedge block or other existing limiting mechanisms. Using a limiting member to achieve the function of allowing only the compression section 501 to contract and not extend is prior art and will not be elaborated further here. This measure aims to solve the problem of pressure fluctuations inside the air inlet cylinder 101 when oxygen inside the air collecting cylinder 102 is backflushed through the air outlet 6.

[0072] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

[0073] Although embodiments of the invention have been shown and described, those skilled in the art will recognize that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A portable oxygen supply device for organ perfusion transport, characterized in that, include: The oxygen generation unit is used to separate and produce high concentrations of oxygen from ambient air; An air-oxygen mixing unit has a first inlet connected to the output of the oxygen generating unit and a second inlet connected to ambient air, used to mix high-concentration oxygen with ambient air in a proportional manner. The gas pressurization unit, whose inlet is connected to the outlet of the air-oxygen mixer unit, is used to pressurize the mixed gas to the working pressure required by the organ perfusion system. The control unit, which is electrically connected to the air-oxygen mixer unit, is used to receive the target oxygen concentration set value and control the mixing ratio of the air-oxygen mixer unit so that the oxygen concentration of the output gas is stabilized at the set value. The control unit has built-in degraded operating mode control logic. When the oxygen generating unit fails, it controls the air-oxygen mixer unit to close its first inlet and fully open its second inlet, so that the system outputs filtered ambient air.

2. The portable oxygen supply device for organ perfusion transport according to claim 1, characterized in that, The control unit receives real-time metabolic parameters from the organ perfusion system through a data communication interface and can dynamically adjust the target oxygen concentration setting value of the air-oxygen mixer unit based on these metabolic parameters.

3. The portable oxygen supply device for organ perfusion transport according to claim 2, characterized in that: The oxygen generation unit includes: Molecular sieve, comprising a gas collecting cylinder, wherein both sides of the gas collecting cylinder are provided with gas inlets, and each gas inlet is provided with a gas inlet and a nitrogen outlet. The gas delivery unit has its output end connected to a first guide pipe and a second guide pipe via a branch tee, and the first guide pipe and the second guide pipe are respectively connected to the air inlets of the air inlets on both sides of the gas collecting cylinder. The nitrogen venting section is connected to a first regulating pipe and a second regulating pipe via a nitrogen venting tee. The first regulating pipe and the second regulating pipe are respectively connected to the nitrogen venting ports of the air inlets on both sides of the gas collecting cylinder.

4. The portable oxygen supply device for organ perfusion transport according to claim 3, characterized in that, The air inlets located at both ends of the air collecting cylinder are connected to the air collecting cylinder through air outlets, which are located at the bottom of the air collecting cylinder. The air intake cylinder is filled with oxygen-generating particles, and a collector is provided on the outside of the air intake cylinder for collecting the pulverized oxygen-generating particles.

5. The portable oxygen supply device for organ perfusion transport according to claim 4, characterized in that, The collection component includes a powder-permeable section disposed on the outside of the air inlet cylinder, and a powder box disposed below the powder-permeable section, the powder box being used to collect pulverized oxygen-generating particles.

6. The portable oxygen supply device for organ perfusion transport according to claim 5, characterized in that, The air inlet cylinder is equipped with a clamping component for compressing the oxygen-generating particles. The clamping component includes: A vent plate is installed inside the air intake cylinder and can move axially along the air intake cylinder; The elastic part has one end connected to the vent plate and the other end connected to one end of the air inlet and air collection cylinder.

7. The portable oxygen supply device for organ perfusion transport according to claim 6, characterized in that, The powder box is equipped with a pressure regulating component, which includes: The receiving part is located inside the toner cartridge and can move axially along the toner cartridge; The pressure-bearing part has one end connected to the receiving part and the other end connected to the powder box; The air duct is equipped with a one-way valve, one end of which is connected to the pressure receiving part, and the other end is connected to the clamping part.

8. The portable oxygen supply device for organ perfusion transport according to claim 7, characterized in that, The air intake cylinder is equipped with a follower, the follower comprising: The extrusion section has one end connected to the vent plate and the other end connected to the end of the air inlet cylinder facing the air collection cylinder; The telescopic section is located between the receiving section and the powder-permeating section, and is connected to the extrusion section via a connecting pipe.

9. The portable oxygen supply device for organ perfusion transport according to claim 8, characterized in that, The end of the air inlet cylinder away from the air collecting cylinder is provided with a cover that is connected to the elastic part, and the cover covers the air inlet and the air outlet.

10. An oxygen supply method for supplying oxygen to a donor organ using the portable oxygen supply device for organ perfusion transport according to any one of claims 1-9, the oxygen supply method comprising the following steps: S1. Start the oxygen generation unit. The oxygen generation unit produces high-concentration oxygen through molecular sieve. S2. The air-oxygen mixing unit automatically draws in filtered ambient air according to the set parameters and mixes it with high-concentration oxygen in a precise ratio. S3. The mixed gas is pressurized to the set pressure by the gas pressurization unit, and then the output flow rate is adjusted by the scavenging flow rate control unit, so that the oxygenated gas that meets the requirements is finally delivered to the organ perfusion system.

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