Oral care composition and preparation method thereof

Abstract

The invention discloses an oral care composition and a preparation method thereof. The oral care composition comprises the following components in percentage by weight: 20-30% of abrasive; 15 to 25% of a humectant; 0.8 to 1.5 percent of a surfactant; the biomimetic mineral repairing agent is a biomimetic mineral peptide which can be self-assembled at the enamel defect part and can guide mineral substances to directionally deposit; 1.5-3% of an oral cavity micro-ecology regulating composition, wherein the regulating composition comprises prebiotics and metabiotics; 0.3-1% of a slow-release antibacterial compound, wherein the slow-release antibacterial compound comprises a coating body of a zinc salt and a biocompatible carrier; 0.1 to 0.2 percent of a stable fluorine source; the pH regulator is used for regulating the pH value of the composition to 6.5-7.5; and the balance of deionized water. The hydrated silica with the particle size of 5-20 microns is adopted as the abrasive, so that stains on the surfaces of teeth are effectively removed.

Description

Technical Field

[0001] This invention relates to the field of oral care composition technology, and more particularly to an oral care composition and its preparation method. Background Technology

[0002] Oral health problems, especially tooth decay (cavities) and enamel wear, are among the most common health issues worldwide, affecting the quality of life for people of all ages. Traditional oral care products, such as toothpaste, rely on two main mechanisms of action: first, the mechanical action of physical abrasives (such as calcium carbonate and hydrated silica) to remove plaque and surface stains; and second, the use of fluoride (such as sodium fluoride and sodium monofluorophosphate) to promote the remineralization of enamel to prevent tooth decay. This classic combination has made significant contributions to the prevention of oral diseases over the past few decades.

[0003] With in-depth research into the structure of tooth enamel and the mechanism of demineralization-remineralization, the limitations of traditional fluoride treatments have become increasingly apparent. The remineralization process induced by fluoride mainly forms an amorphous or randomly oriented hydroxyapatite deposit layer on the enamel surface. This deposit layer has a loose structure and weak mechanical properties, which is far removed from the highly ordered and tightly arranged hydroxyapatite crystal structure of natural tooth enamel. Therefore, for early caries that have already formed, traditional remineralization technology has poor targeting and low repair efficiency. It is difficult to penetrate deep into the micropores of enamel and rebuild its original crystal structure and mechanical strength, and cannot fundamentally reverse early lesions. At the same time, modern dietary habits (high sugar, high acid) and the accelerated pace of life have led to teeth facing more frequent demineralization challenges and more complex wear. The public's expectations for oral care are no longer satisfied with basic cleaning and passive caries prevention, but instead seek more proactive repair, more lasting protection, and a more comfortable user experience.

[0004] Therefore, there is an urgent need in this field for a groundbreaking innovative oral care solution that can simulate the natural formation process of tooth enamel in living organisms, enabling accurate identification and efficient repair of early damage. This would not only greatly improve the repair efficacy of early caries and extend the life of teeth, but also provide consumers with an oral care experience that surpasses traditional products, offering greater restorative value and a greater sense of security, representing an important future development direction in this field. Summary of the Invention

[0005] The purpose of this invention is to address the shortcomings of existing technologies by proposing an oral care composition and its preparation method.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: An oral care composition comprising the following weight percentages: Friction agent: 20-30%; Moisturizer: 15-25%; Surfactant: 0.8-1.5%; Bionic mineral repair agent: 0.05-0.2%. The bionic mineral repair agent is a bionic mineral peptide that can self-assemble at the enamel defect site and guide the directional deposition of minerals. Oral microecological regulation composition: 1.5-3%, wherein the regulation composition includes prebiotics and postbiotics; Sustained-release antibacterial complex: 0.3-1%, wherein the sustained-release antibacterial complex comprises a zinc salt and a biocompatible carrier encapsulation; Stable fluorine source: 0.1-0.2%; pH adjuster: used to adjust the pH of the composition to 6.5-7.5; Deionized water balance.

[0007] As a further aspect of the present invention: the biomimetic mineral peptide is a P11-4 peptide.

[0008] As a further aspect of the present invention: the oral microecological regulation composition contains: Prebiotics are selected from at least one of xylooligosaccharides and erythritol, and are used to selectively promote the growth of beneficial bacteria in the oral cavity; The metabiotic is an inactivated Lactobacillus paracasei lysate.

[0009] As a further aspect of the present invention: the sustained-release antibacterial complex is a coating formed by zinc citrate and hydroxyapatite.

[0010] As a further embodiment of the present invention: the friction agent is hydrated silica with a particle size concentrated in the range of 5-20 micrometers; the surfactant is sodium lauroyl sarcosinate; and the stable fluorine source is sodium monofluorophosphate.

[0011] As a further embodiment of the present invention, the composition further comprises 0.01-0.1% dipotassium glycyrrhizate.

[0012] A method for preparing an oral care composition includes the following steps: S1: Preparation of aqueous phase: Deionized water, humectant, pH adjuster, prebiotic and slow-release antibacterial complex are mixed, heated to 40-45℃ and stirred evenly to obtain aqueous phase A; S2: Preparation of composite active powder: The biomimetic mineral peptide is dissolved in water at a low temperature of 2-10℃ to obtain a peptide solution; at the same time, the post-genetic powder is dry-blended and modified in a dry state to uniformly coat or tightly bind to the surface of the biomimetic mineral peptide to form composite active powder B. S3: Mixing basic components: Cool the aqueous phase A to below 30°C, add the abrasive and surfactant, and stir at medium speed until homogeneous; then, under low speed stirring, slowly add the peptide solution obtained in step S2; S4: Dispersing the composite active component: Maintain the system temperature at 25±2℃, and under the protection of inert gas, slowly add the composite active powder B to the system in step S3, and use ultrasonic-assisted dispersion technology to disperse it evenly. S5: Homogenization: Add a stable fluorine source and any other remaining components, and continue to stir gently until the paste is homogeneous; S6: Post-processing: The paste is degassed under vacuum and then aseptically filled at room temperature or low temperature.

[0013] As a further aspect of the present invention: in step S2, the dry blending modification is carried out in a high-speed pulverizer with a rotation speed of 5000-10000 rpm and a processing time of 5-10 minutes.

[0014] As a further aspect of the present invention: in step S4, the inert gas is nitrogen, and the flow rate is 0.5-1 liters / minute; the power of the ultrasonic-assisted dispersion is 200-400W, and an intermittent ultrasonic mode is used, with each ultrasonic session lasting 3-5 seconds, an interval of 10-15 seconds, and repeated 5-10 times.

[0015] As a further embodiment of the present invention: in step S6, the vacuum degree of the vacuum degassing is -0.08 to -0.1 MPa, and the degassing time is 15-30 minutes.

[0016] Compared with the prior art, the present invention provides an oral care composition and its preparation method, which has the following beneficial effects: 1. Using hydrated silica with a particle size concentrated in 5-20 micrometers as an abrasive, it effectively removes stains from the tooth surface while minimizing damage to the enamel caused by excessive abrasion, achieving a balance between cleaning effect and safety.

[0017] 2. The added biomimetic mineral peptide P11-4 can self-assemble into a three-dimensional fiber network scaffold at the site of early caries in tooth enamel, specifically adsorbing and guiding the orderly deposition of calcium and phosphorus ions, thereby achieving directional regeneration of tooth enamel crystals. Compared with ordinary remineralization technology, the repair efficiency is significantly improved, providing an advanced repair solution for early caries.

[0018] 3. By selectively promoting the growth of beneficial oral bacteria (such as Streptococcus salivarius) through prebiotics (xylooligosaccharides, erythritol), and competitively inhibiting the adhesion of pathogenic bacteria (such as Streptococcus mutans, Porphyromonas gingivalis) through postbiotics (inactivated Lactobacillus paracasei lysate), and supplemented by zinc salt complex (zinc citrate / hydroxyapatite coating) to achieve the slow release of zinc ions, it provides multiple effects such as long-lasting antibacterial, anti-odor-producing bacteria and inhibition of tartar formation, while reducing the irritation of the mucosa to traditional ingredients, and helps to establish a healthy oral microecological balance.

[0019] 4. A stable fluoride source (sodium monofluorophosphate) enhances the acid resistance of newly formed minerals, synergistically improving the remineralization effect of biomimetic mineral peptides and jointly enhancing the teeth's resistance to cavities. Furthermore, the addition of soothing ingredients such as dipotassium glycyrrhizate further enhances the formula's anti-inflammatory and gum-soothing effects, providing more comprehensive oral care.

[0020] 5. Refined preparation processes such as low-temperature treatment, inert gas protection, and ultrasonic-assisted dispersion are adopted. For example, biomimetic mineral peptides are dissolved in low-temperature water, and post-biotics are dry-blended and modified and added under nitrogen protection, which effectively prevents premature aggregation or inactivation of peptide molecules. Vacuum degassing and aseptic filling are used to ensure the uniformity and fineness of the paste and the stability of active ingredients, so that the final product has good safety and expected efficacy at a mild pH (6.5-7.5).

[0021] The parts of this device not covered herein are the same as or implemented using existing technologies. This invention has a simple structure and is easy to operate. Attached Figure Description

[0022] Figure 1 This is a flowchart of a method for preparing an oral care composition according to the present invention. Detailed Implementation

[0023] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments.

[0024] Example 1: An oral care composition comprising, by weight percentage: Abrasive: Hydrated silica with a particle size of 5-20 microns, which can effectively clean stains on the tooth surface while minimizing excessive wear on the enamel; Moisturizers: including glycerin and sorbitol, with glycerin accounting for 70%-80% and sorbitol accounting for 20%-30%; Surfactant: Sodium lauroyl sarcosinate; pH adjusters: including sodium hydroxide and sodium bicarbonate, to ensure that the pH of the final product is stable at 6.5-7.5; Bionic mineral peptide: P11-4. This peptide can self-assemble into a three-dimensional fiber network scaffold at the site of early caries in tooth enamel. It specifically adsorbs and guides calcium and phosphorus ions in A to be deposited in an orderly manner on it, realizing the directional regeneration of bionic enamel crystals. The repair efficiency is far superior to ordinary remineralization. Stabilizing fluorine source: Sodium monofluorophosphate, which enhances the acid resistance of newly formed minerals; Prebiotics: xylooligosaccharides and erythritol selectively promote the colonization and growth of beneficial oral bacteria (such as Streptococcus salivarius); Postbiotic: Inactivated Lactobacillus paracasei lysate competitively inhibits the adhesion of pathogenic bacteria (such as Streptococcus mutans and Porphyromonas gingivalis) through its residual cell wall components and metabolites, and mildly modulates the immune response to reduce gingival inflammation; Zinc salt complex: Zinc citrate / hydroxyapatite coating, which achieves slow release of zinc ions through carrier coating, provides long-lasting antibacterial (anti-odor-producing bacteria) and tartar-inhibiting effects, while reducing irritation to the mucosa; Deionized water.

[0025] Example 2: An oral care composition, prepared according to the following weight percentages: hydrated silica 25%; glycerin 15%; sorbitol 5%; sodium lauroyl sarcosinate 1.2%; biomimetic mineral peptide P11-4 0.1%; sodium monofluorophosphate 0.14%; xylooligosaccharide 1%; inactivated Lactobacillus paracasei lysate 0.8%; zinc citrate / hydroxyapatite coating 0.5%; dipotassium glycyrrhizate 0.05%; deionized water balance; pH adjusted to 7.0 with a pH adjuster.

[0026] Example 3: A method for preparing an oral care composition, comprising the following steps: S1: In a vacuum homogenizer, add deionized water and humectant, and dissolve pH adjuster, prebiotic, zinc salt complex and post-biotic components while stirring. Heat to 40-45℃ and mix evenly to obtain aqueous phase A. Set the stirring speed to 100-200 rpm and the stirring time to 15-30 minutes to ensure that all ingredients are fully dissolved and mixed evenly. Use water bath heating or electric heating mantle heating, and control the heating rate to avoid local overheating that could cause component deterioration; heat to 40-45℃. S2: Dissolve the biomimetic mineral peptide (P11-4) separately in a small amount of low-temperature water, and dry-mix the post-genetic powder in a high-speed pulverizer under dry conditions to make the latter uniformly coat the surface of the former, forming composite active powder B. When dissolving biomimetic mineral peptides (P11-4) alone in a small amount of low-temperature water, the specific water volume range is determined according to the solubility of the biomimetic mineral peptides. For example, add 5-10 ml of low-temperature water per gram of biomimetic mineral peptides. The temperature range of the low-temperature water is clearly defined as 2-10℃ to prevent denaturation of the biomimetic mineral peptides during the dissolution process; The specific parameters for the dry blending modification of post-generic powder in a high-speed pulverizer under dry conditions are as follows: the pulverizer speed is set to 5000-10000 rpm and the pulverizing time is 5-10 minutes. S3: Cool the aqueous phase A to below 30°C, add the basic abrasive and surfactant, stir at medium speed until uniform, and slowly add the dissolved biomimetic mineral peptide solution while stirring at low speed. After adding the basic abrasive and surfactant, the stirring speed range is 300-500 rpm, and the stirring time is 10-15 minutes. When slowly adding the dissolved biomimetic mineral peptide solution under low-speed stirring, the stirring speed range is 50-100 rpm to avoid generating too many bubbles and prevent peptide molecules from aggregating too early. S4: Maintain the system temperature at 25±2℃, and under the protection of inert gas (nitrogen), slowly add composite active powder B, and use ultrasonic-assisted dispersion technology (power 300W, intermittent ultrasound) to disperse it evenly and avoid premature aggregation of peptide molecules. When adding composite active powder B, the nitrogen flow rate should be in the range of 0.5-1 L / min to ensure that the system is in a good inert gas protective environment; When using ultrasonic-assisted dispersion technology (300W power, intermittent ultrasound), the duration and interval of each ultrasound session are 3-5 seconds each, with an interval of 10-15 seconds, repeated 5-10 times to ensure uniform dispersion of composite active powder B. S5: Add a stable fluoride source and any other remaining components, and continue to stir gently until the paste is uniform and smooth; After adding a stable fluorine source and any other remaining components, the stirring speed and time range is 100-200 rpm for 20-30 minutes to ensure a uniform and smooth paste.

[0027] S6: Transfer the ointment to a vacuum degassing cylinder for degassing, and perform aseptic filling at the same temperature to avoid high temperature damage to the active ingredients;

[0028] The vacuum level during the degassing process in the vacuum degassing cylinder is between -0.08 and -0.1 MPa, and the degassing time is 15-30 minutes to remove air bubbles from the paste.

[0029] Example 4: A method for preparing an oral care composition. The paste was formulated according to the proportions in Example 2 and then prepared using the method in Example 3. After preparation, the prepared paste and Comparative Example 1 (a commercially available paste) were used for brushing teeth. The biomimetic mineralization effect and the stability of the biomimetic peptide active ingredients after 7 days of brushing were tested, as well as after storage at 40°C for 3 months. The test results are shown in Table 1. Test Project Example 2 Comparative Example 1 Microhardness recovery rate of glaze surface 90% 80% Stability of biomimetic peptide active ingredients high middle Table 1

[0030] As shown in Table 1, when brushing teeth was simulated using the paste from Example 2 and Comparative Example 1 respectively, the microhardness of the enamel surface in Example 2 recovered to 90% of that of healthy enamel after 7 days, while that in Comparative Example 1 only recovered to 80%. After the product of Example 2 was stored at 40°C for 3 months, its biomimetic peptide activity was higher than that of Comparative Example 1, and its component stability was also higher.

[0031] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. An oral care composition, characterized in that, Includes the following weight percentages: Friction agent: 20-30%; Moisturizer: 15-25%; Surfactant: 0.8-1.5%; Bionic mineral repair agent: 0.05-0.2%. The bionic mineral repair agent is a bionic mineral peptide that can self-assemble at the enamel defect site and guide the directional deposition of minerals. Oral microecological regulation composition: 1.5-3%, wherein the regulation composition includes prebiotics and postbiotics; Sustained-release antibacterial complex: 0.3-1%, wherein the sustained-release antibacterial complex comprises a zinc salt and a biocompatible carrier encapsulation; Stable fluorine source: 0.1-0.2%; pH adjuster: used to adjust the pH of the composition to 6.5-7.5; Deionized water balance.

2. The oral care composition according to claim 1, characterized in that, The biomimetic mineral peptide is P11-4 peptide.

3. The oral care composition according to claim 1, characterized in that, In the oral microecological regulation composition: Prebiotics are selected from at least one of xylooligosaccharides and erythritol, and are used to selectively promote the growth of beneficial bacteria in the oral cavity; The metabiotic is an inactivated Lactobacillus paracasei lysate.

4. The oral care composition according to claim 1, characterized in that, The sustained-release antibacterial complex is a coating formed by zinc citrate and hydroxyapatite.

5. The oral care composition according to claim 1, characterized in that, The abrasive is hydrated silica with a particle size concentrated in the range of 5-20 micrometers; the surfactant is sodium lauroyl sarcosinate; and the stable fluorine source is sodium monofluorophosphate.

6. The oral care composition according to claim 1, characterized in that, The composition also contains 0.01-0.1% dipotassium glycyrrhizate.

7. A method for preparing an oral care composition according to any one of claims 1-6, characterized in that, Includes the following steps: S1: Preparation of aqueous phase: Deionized water, humectant, pH adjuster, prebiotic and slow-release antibacterial complex are mixed, heated to 40-45℃ and stirred evenly to obtain aqueous phase A; S2: Preparation of composite active powder: The biomimetic mineral peptide is dissolved in water at a low temperature of 2-10℃ to obtain a peptide solution; at the same time, the post-genetic powder is dry-blended and modified in a dry state to uniformly coat or tightly bind to the surface of the biomimetic mineral peptide to form composite active powder B. S3: Mixing basic components: Cool the aqueous phase A to below 30°C, add the abrasive and surfactant, and stir at medium speed until homogeneous; then, under low speed stirring, slowly add the peptide solution obtained in step S2; S4: Dispersing the composite active component: Maintain the system temperature at 25±2℃, and under the protection of inert gas, slowly add the composite active powder B to the system in step S3, and use ultrasonic-assisted dispersion technology to make it uniformly dispersed. S5: Homogenization: Add a stable fluorine source and any other remaining components, and continue to stir gently until the paste is homogeneous; S6: Post-processing: The paste is degassed under vacuum and then aseptically filled at room temperature or low temperature.

8. The method for preparing an oral care composition according to claim 7, characterized in that, In step S2, the dry blending modification is carried out in a high-speed pulverizer at a speed of 5000-10000 rpm for a processing time of 5-10 minutes.

9. A method for preparing an oral care composition according to claim 7, characterized in that, In step S4, the inert gas is nitrogen, with a flow rate of 0.5-1 liters / minute; the ultrasonic-assisted dispersion power is 200-400W, using an intermittent ultrasonic mode, with each ultrasonic session lasting 3-5 seconds, an interval of 10-15 seconds, and repeated 5-10 times.

10. A method for preparing an oral care composition according to claim 7, characterized in that, In step S6, the vacuum degree of the vacuum degassing is -0.08 to -0.1 MPa, and the degassing time is 15-30 minutes.

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