Pharmaceutical composition containing adapalene and benzoyl peroxide and preparation method thereof

By improving the drug composition and preparation method, the problem of local skin irritation in existing acne treatments has been solved, significantly reducing the incidence of dryness, erythema, desquamation, burning sensation and contact dermatitis, and improving the patient's treatment experience and compliance.

CN121818792APending Publication Date: 2026-04-10JIANGSU SEMPOLL PHARMA
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Patent Information

Application Number
CN202610138228.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-01-31
Publication Date
2026-04-10

AI Technical Summary

Technical Problem

The existing adapalene and benzoyl peroxide compound gel has a high incidence of local skin dryness, erythema, desquamation, burning sensation and contact dermatitis when used to treat acne, which affects patient tolerance and treatment compliance.

Method used

A topical gel is prepared using a pharmaceutical composition comprising adapalene, benzoyl peroxide, traditional Chinese medicine extracts, acrylamide and a copolymer of sodium acryloyl dimethyl taurate and a mixture of isohexadecane and polysorbate 80, sodium docusate, disodium EDTA, glycerin, poloxamer 124, propylene glycol and water. This gel is prepared using phase separation pretreatment and stepwise emulsification techniques to ensure uniform dispersion of active ingredients and reduce mutual interference.

Benefits of technology

It significantly reduced the incidence of local skin dryness, erythema, desquamation, burning sensation and contact dermatitis, improved patient treatment comfort and medication adherence, and maintained the synergistic antibacterial and antikeratotic efficacy of adapalene and benzoyl peroxide.

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Abstract

The invention relates to a pharmaceutical composition, which is prepared from adapalene, benzoyl peroxide, a traditional Chinese medicine extract, an acrylamide and acryloyl dimethyl sodium taurate copolymer, a mixture of isohexadecane and polysorbate 80, docusate sodium, EDTA (Ethylene Diamine Tetraacetic Acid) disodium, glycerol, poloxamer 124, propylene glycol and water, the traditional Chinese medicine extract comprises moutan bark, salvia miltiorrhiza, radix rehmanniae recen, radix sophorae flavescentis, coptis chinensis, rheum officinale, scutellaria baicalensis, menthol and borneol. According to the pharmaceutical composition disclosed by the invention, the synergistic antibacterial and anti-keratosis curative effects of adapalene and benzoyl peroxide can be maintained, and meanwhile, the occurrence rate of local skin dryness, erythema, desquamation, burning heat sensation and contact dermatitis can be remarkably reduced.
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