Traditional Chinese medicine composition for treating infertility and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating infertility, which is prepared from the following raw materials: radix rehmanniae recen, radix paeoniae alba, turtle shell, cortex moutan, peach kernel, ginseng, radix glehniae, medlar, oyster, rhizoma cyperi, radix curcumae, astragalus membranaceus, angelica sinensis, rhizoma anemarrhenae, golden cypress, lotus seed, rhizoma atractylodis macrocephalae, pericarpium citri reticulatae, chicken's gizzard-membrane, radix bupleuri, tetrapanax papyriferus, donkey-hide gelatin, eucommia ulmoides and deer glue. Spleen tonifying, blood nourishing, phlegm reducing and dampness clearing; the effects of soothing liver-qi stagnation, promoting qi and activating blood are achieved; qi is benefited, blood is nourished, and Zhongzhou is promoted to regenerate Qi and blood; promoting blood circulation to remove blood stasis and dredging Chong and Ren qi; the traditional Chinese medicine composition has the effects of clearing heat, promoting diuresis, eliminating dampness and reducing phlegm, can achieve sufficient qi and blood of liver and kidney and smooth Chong and Ren channels, has a good treatment effect on male and female infertility caused by various reasons, and is particularly suitable for female infertility caused by kidney deficiency, weakness, fallopian tube blockage, cold uterus, kidney deficiency type ovulation disorder, obesity, stasis, weakness, blood deficiency and the like; and the traditional Chinese medicine composition is also suitable for male infertility caused by cold sperm, rare sperm, oligospermia and necrospermia due to kidney deficiency.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical technology, and in particular to a traditional Chinese medicine composition for infertility and its application. Background Technology

[0002] In medicine, infertility is generally defined as the inability to conceive after one year of marriage for couples of reproductive age. Clinically, there are three categories: ① Infertility is defined as the inability to conceive after one year of regular, unprotected sexual intercourse; ② Primary infertility is defined as the inability to conceive after one year of unprotected sexual intercourse; ③ Secondary infertility is defined as the inability to conceive after a previous pregnancy and subsequent unprotected intercourse for one year. Infertility is a common problem, affecting at least 10% to 15% of couples of reproductive age. The causes of infertility are divided into male infertility and female infertility. From the perspective of female etiology, ovulation factors, fallopian tube factors, cervical factors, and endometriosis are the main causes of female infertility. From the perspective of male etiology, the main causes include factors such as decreased spermatogenesis, vas deferens factors, abnormal semen, and sexual dysfunction. Currently, infertility is usually treated by taking Western medicine or traditional Chinese medicine to regulate bodily functions. Western medicine often leads to side effects such as weight gain and the treatment process is quite painful. While some traditional Chinese medicine formulas have certain effects, the treatment process is long and the effects are not significant. Summary of the Invention

[0003] Therefore, based on the above background, the present invention provides a traditional Chinese medicine composition for infertility and its application.

[0004] The technical solution of the present invention is as follows:

[0005] A traditional Chinese medicine composition for treating infertility, comprising the following raw materials in parts by weight:

[0006] 30-50 parts Rehmannia glutinosa, 20-30 parts Paeonia lactiflora, 30-60 parts Trionyx sinensis, 20-30 parts Paeonia suffruticosa, 20-30 parts Prunus persica, 10-15 parts Panax ginseng, 20-35 parts Adenophora stricta, 30-60 parts Lycium barbarum, 30-50 parts Ostrea gigas, 20-30 parts Cyperus rotundus, 20-30 parts Curcuma longa, 20-30 parts Astragalus membranaceus, 30-50 parts Angelica sinensis, 20-30 parts Anemarrhena asphodeloides, 20-30 parts Phellodendron chinense, 15-30 parts Nelumbo nucifera, 30-50 parts Atractylodes macrocephala, 20-30 parts Citrus reticulata, 30-50 parts Chicken gizzard, 20-30 parts Bupleurum chinense, 20-30 parts Tetrapanax papyriferus, 30-50 parts Colla corii asini, 20-30 parts Eucommia ulmoides, 20-30 parts Deer antler glue.

[0007] Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight:

[0008] 50 parts Rehmannia glutinosa, 30 parts Paeonia lactiflora, 60 parts Trionyx sinensis, 20 parts Paeonia suffruticosa, 20 parts Prunus persica, 15 parts Ginseng, 35 parts Adenophora stricta, 40 parts Lycium barbarum, 40 parts Ostrea gigas, 30 parts Cyperus rotundus, 30 parts Curcuma longa, 30 parts Astragalus membranaceus, 50 parts Angelica sinensis, 30 parts Anemarrhena asphodeloides, 20 parts Phellodendron chinense, 15 parts Nelumbo nucifera, 50 parts Atractylodes macrocephala, 30 parts Citrus reticulata, 30 parts Chicken gizzard, 20 parts Bupleurum chinense, 20 parts Tetrapanax papyriferus, 40 parts Colla corii asini, 30 parts Eucommia ulmoides, 30 parts Deer antler glue.

[0009] Based on the same inventive concept, the present invention also provides a medicine for treating male infertility, which is made from the above-mentioned traditional Chinese medicine composition.

[0010] Preferably, the drug is an oral preparation.

[0011] Furthermore, the drug may be in the form of pills, capsules, tablets, powders, granules, or oral liquids.

[0012] Furthermore, it also includes 20-30 parts of motherwort.

[0013] Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight:

[0014] 50 parts Rehmannia glutinosa, 30 parts Paeonia lactiflora, 60 parts Trionyx sinensis, 20 parts Paeonia suffruticosa, 20 parts Prunus persica, 15 parts Ginseng, 35 parts Adenophora stricta, 40 parts Lycium barbarum, 40 parts Ostrea gigas, 30 parts Cyperus rotundus, 30 parts Curcuma longa, 30 parts Astragalus membranaceus, 50 parts Angelica sinensis, 30 parts Anemarrhena asphodeloides, 20 parts Phellodendron chinense, 15 parts Nelumbo nucifera, 50 parts Atractylodes macrocephala, 30 parts Citrus reticulata, 30 parts Chicken gizzard, 20 parts Bupleurum chinense, 20 parts Tetrapanax papyriferus, 40 parts Colla corii asini, 30 parts Eucommia ulmoides, 30 parts Deer antler glue, 20 parts Leonurus japonicus.

[0015] Based on the same inventive concept, the present invention also provides a medicine for treating female infertility, which is made from the above-mentioned traditional Chinese medicine composition.

[0016] Preferably, the drug is an oral preparation.

[0017] Furthermore, the drug may be in the form of pills, capsules, tablets, powders, granules, or oral liquids.

[0018] The pharmacological properties of each active pharmaceutical ingredient in the formulation of this invention are as follows:

[0019] Rehmannia root has a sweet and bitter taste, and is cold in nature. It enters the heart, liver, and kidney meridians. The sweetness outweighs the bitterness; it is moist and nourishing, while its bitter and cold properties clear and drain. Entering the heart and liver meridians, it clears heat, cools the blood, relieves irritability, and stops bleeding; entering the kidney meridian, it nourishes yin, generates fluids, lubricates the large intestine, quenches thirst, and promotes bowel movements. It addresses both pathogenic factors and strengthens the body's resistance, and is suitable for those with blood heat, yin deficiency with heat, yin and blood deficiency, and dry intestines due to fluid depletion. It is most suitable for those with excessive heat and yin deficiency. It clears heat, cools the blood, nourishes yin, and generates fluids.

[0020] White peony root tastes bitter and sour, is slightly cold in nature, and enters the liver and spleen meridians. It nourishes blood and regulates menstruation, astringes yin and stops sweating, softens the liver and relieves pain, and calms liver yang.

[0021] Turtle shell is salty in taste and slightly cold in nature, and enters the liver and kidney meridians. Its saltiness softens hardness, its heavy nature calms and subdues, and its cold nature clears and drains. Entering the liver and kidney meridians, it nourishes kidney yin, reduces fever and eliminates steaming sensation, and also calms and subdues liver yang, softens hardness and disperses nodules. It is good for treating yin deficiency and yang hyperactivity, internal wind stirring, yin deficiency fever, chronic malaria, and tumor emaciation.

[0022] Moutan bark is bitter and pungent in taste, slightly cold in nature, and enters the heart, liver, and kidney meridians. Its bitterness and pungent nature disperse, and its slight coldness clears and disperses. Entering the heart and liver meridians, it effectively clears heat, cools the blood, and promotes blood circulation; entering the kidney meridian, it reduces deficiency heat. It combines clearing blood heat, reducing deficiency heat, and dispersing blood stasis into one, and can be used for all types of blood heat, blood stasis, and deficiency heat, whether single or combined, especially suitable for those with blood heat and stasis, blood stasis and heat, deficiency heat with stasis, or those with bone steaming without sweating. It clears heat, cools the blood, and promotes blood circulation.

[0023] Peach kernels are bitter and sweet in taste, neutral in nature, and enter the heart, liver, and large intestine meridians. They invigorate blood circulation, remove blood stasis, moisten the intestines, and promote bowel movements.

[0024] Ginseng has a sweet and slightly bitter taste, and is slightly warm in nature. It enters the spleen, lung, heart, and kidney meridians. Its sweetness nourishes and its slight warmth, combined with its slight bitterness, makes it a powerful medicine for tonifying qi and strengthening the body. It is good at greatly replenishing vital energy and treating qi deficiency and impending collapse; it is also good at replenishing the qi of the spleen and lungs and treating various symptoms of spleen and lung qi deficiency; it can also replenish qi to generate body fluids, calm the mind, and improve intelligence, treating thirst due to fluid depletion, diabetes, restlessness, palpitations, and forgetfulness.

[0025] North American ginseng is sweet and slightly bitter in taste, and slightly cold in nature. It enters the lung and stomach meridians. Its sweet taste can nourish, and its slightly cold nature can clear and drain. It enters the lung and stomach meridians and is a cooling tonic. It is good at nourishing yin and clearing the lungs, benefiting the stomach and generating fluids. It can treat various symptoms of lung and stomach yin deficiency with heat.

[0026] Goji berries are sweet in taste and neutral in nature, and enter the liver and kidney meridians. They are moistening and nourishing, neutral but slightly warm, and enter the liver, kidney, and lung meridians. They are good at nourishing the liver and kidneys and improving eyesight, and can treat liver and kidney yin deficiency and decreased vision; they can also nourish lung yin and stop cough, and treat yin deficiency cough.

[0027] Oysters are salty in taste and slightly cold in nature. They enter the liver and kidney meridians; they have a strong calming effect, nourish yin and yang, and soften hardness and dissipate nodules.

[0028] Cyperus rotundus has a pungent, slightly bitter, and slightly sweet taste, and is neutral in nature. It enters the liver, spleen, and triple burner meridians. Its pungent aroma disperses, its slightly bitter taste slightly descends, and its slightly sweet taste harmonizes, making it balanced without being biased. Entering the liver and triple burner meridians, it is excellent at soothing the liver, regulating qi, and relieving pain. It is a superior herb for soothing the liver and regulating qi, and was praised by Li Shizhen as "the general manager of qi-related diseases and the chief commander of gynecology." When liver qi is smooth and qi and blood are in harmony, menstruation will naturally regulate and pain can be relieved. Therefore, it is also an essential medicine for regulating menstruation and relieving pain.

[0029] Turmeric has a pungent and bitter taste, is cold in nature, and enters the liver, heart, and lung meridians; it promotes qi circulation and removes blood stasis, clears the heart and relieves depression, and benefits the gallbladder and reduces jaundice.

[0030] Astragalus has a sweet taste and slightly warm nature, and enters the spleen and lung meridians. Its sweet and warm properties tonify and promote upward movement, while its bland taste promotes diuresis and drainage. When used raw, it is slightly warm, while when processed with honey, it is warm in nature. It enters the spleen and lung meridians, primarily to support the body's vital energy, and also to eliminate dampness. It is good at tonifying the middle qi and raising clear yang, as well as tonifying lung qi, benefiting the stomach and consolidating the exterior. It treats spleen and lung qi deficiency, sinking of middle qi, qi failing to control blood, spontaneous sweating and night sweats, etc. It can also promote the healing of sores and reduce swelling, and treat carbuncles and boils that fail to ulcerate or ulcerate for a long time due to insufficient qi and blood, as well as edema due to qi deficiency and difficulty in urination.

[0031] Angelica sinensis has a sweet and pungent taste, and is warm in nature. It enters the liver, heart, and spleen meridians. Its sweetness nourishes and moistens, while its pungent and warm properties promote circulation. It primarily enters the liver and heart meridians, and secondarily the spleen meridian. It is good at nourishing and invigorating blood, regulating menstruation and relieving pain, moistening the intestines and promoting bowel movements, and dispelling cold. It is suitable for all symptoms of blood deficiency and blood stasis with cold, and is especially good for those with dry intestines and constipation. It is an essential medicine for regulating menstruation in gynecology, an excellent blood tonic in internal medicine, and is also commonly used in surgery and traumatology for reducing swelling and treating injuries.

[0032] Anemarrhena asphodeloides has a bitter and sweet taste, is cold in nature, and enters the lung, stomach, and kidney meridians. Its bitterness clears heat and drains cold, while its sweetness moistens and nourishes. It enters not only the lung and stomach meridians but also the kidney and large intestine meridians. It clears and descends without dispersing, and also nourishes yin. It clears lung heat and drains fire from the upper body, clears stomach heat and relieves thirst from the middle body, and nourishes kidney yin from the lower body, moistening dryness, lubricating the intestines, and reducing deficiency heat. While its heat-clearing and fire-draining effects are not as strong as gypsum, it excels at nourishing yin and moistening dryness, combining the elimination of pathogens with the support of the body's vital energy. It is suitable for both excess heat and deficiency heat, and is especially beneficial for high fever, dryness-heat damaging body fluids, and yin deficiency fever.

[0033] Phellodendron bark is bitter and cold in nature, and enters the kidney and bladder meridians. Its bitterness clears heat and cold, and its drying and descending properties allow it to enter the kidney and bladder meridians. It clears and drains excess heat (fire) and relieves heat toxicity, dries dampness and eliminates damp toxicity to relieve damp-heat, and clears kidney fire (ministerial fire) to reduce deficiency heat. It is an essential medicine for treating damp-heat and fire toxicity, and is widely used for related symptoms. Compared to Coptis chinensis, its heat-clearing and dampness-drying effects are weaker, and its effects are more focused on the kidneys and lower jiao (lower burner) and bladder. It is best at clearing ministerial fire, reducing deficiency heat, and eliminating damp-heat in the lower burner. It combines clearing excess heat, damp-heat, and reducing deficiency heat, making it suitable for all types of excess heat and fire toxicity, damp-heat, and deficiency heat.

[0034] Lotus seeds are sweet and astringent in taste, neutral in nature, and enter the spleen, kidney, and heart meridians; they tonify the spleen and stop diarrhea, stop leukorrhea, benefit the kidneys and astringe essence, and nourish the heart and calm the mind.

[0035] Atractylodes macrocephala has a bitter and sweet taste, and is warm in nature. It enters the spleen and stomach meridians. Its sweetness nourishes and promotes diuresis, while its bitterness and warmth dry it. Entering the spleen and stomach meridians, it mainly warms and tonifies to support the body's vital energy, and can also remove dampness. It is good at tonifying qi and strengthening the spleen, drying dampness and promoting diuresis, stopping sweating, and calming the fetus. It treats spleen and stomach qi deficiency, spleen deficiency edema, phlegm retention, spontaneous sweating due to superficial deficiency, and threatened abortion.

[0036] Dried tangerine peel is bitter and pungent in taste, warm in nature, and enters the lung and spleen meridians. Its pungent aroma disperses, while its bitter and drying properties warm and transform, entering the spleen and lung meridians. It regulates the ascending and descending of qi in the spleen and lungs, thus harmonizing qi and the middle jiao (middle burner), and also dries dampness, regulates qi, and resolves phlegm. It can be used for all symptoms of qi stagnation, dampness obstruction, and phlegm accumulation. It is especially effective for treating qi stagnation in the middle jiao, and is most suitable for those with concurrent cold symptoms.

[0037] Chicken gizzard lining, also known as chicken inner lining, is sweet in taste and neutral in nature, entering the spleen, stomach, small intestine, and bladder meridians. Its sweetness benefits the middle jiao (spleen and stomach), its neutrality is balanced, and it has a strong astringent and digestive effect. Entering the spleen and stomach meridians, it effectively invigorates the spleen and stomach, promotes digestion, and eliminates food stagnation, making it an essential medicine for digestion and spleen health. Entering the small intestine and bladder meridians, it not only dissolves hardened masses and promotes digestion but also strengthens the kidneys and stops seminal emission, making it a suitable choice for treating stones, enuresis, and seminal emission.

[0038] Bupleurum root has a pungent and bitter taste, and is slightly cold in nature. It enters the liver, gallbladder, and lung meridians. Its bitterness disperses and its pungent nature disperses, its aromatic nature ascends, and its slightly cold nature clears. It enters the liver and gallbladder meridians. It disperses pathogenic qi in the gallbladder meridian to harmonize and reduce fever, disperses stagnant qi in the liver and gallbladder meridians to soothe the liver and relieve depression, and also raises the clear yang qi of the liver and gallbladder to lift sunken qi. It is a principal medicine for the liver and gallbladder meridians. When used raw, it has both ascending and dispersing properties, while when processed with vinegar, its ascending and dispersing properties decrease, but its liver-soothing properties increase.

[0039] Tetrapanax papyrifer has a sweet and bland taste, is slightly cold in nature, and enters the lung and stomach meridians; it clears heat, promotes urination, and promotes lactation.

[0040] Donkey-hide gelatin has a sweet taste and neutral properties, and enters the lung, liver, and kidney meridians; it nourishes blood, stops bleeding, and moistens dryness.

[0041] Eucommia ulmoides has a sweet taste and warm nature, and enters the liver and kidney meridians. Its sweet and warm properties are nourishing, and its medicinal effects are quite strong. It effectively warms and tonifies the liver and kidneys, strengthens muscles and bones, stabilizes pregnancy, and lowers blood pressure. It is an essential medicine for treating kidney deficiency, lower back and knee pain, or weakness of muscles and bones, and is also an excellent remedy for threatened abortion or fetal movement due to liver and kidney deficiency.

[0042] Deer glue has a sweet taste and warm properties, and it enters the liver and kidney meridians; it warms and nourishes the liver and kidneys, and replenishes essence and blood.

[0043] Motherwort has a bitter and pungent taste, and is slightly cold in nature. It enters the liver, pericardium, and bladder meridians. Its pungent and bitter properties disperse and drain, and its slightly cold nature clears and resolves. It mainly enters the heart and liver meridians, and also the bladder meridian. It can invigorate blood and remove blood stasis, treating various diseases caused by blood stasis, especially those related to menstruation and childbirth, making it an excellent medicine for regulating menstruation in gynecology. It can also promote diuresis, reduce swelling, clear heat and detoxify, treating edema caused by water retention and blood stasis, as well as sores and rashes caused by heat toxin accumulation. It is suitable for those with blood heat and blood stasis, edema, or sores and rashes with blood stasis.

[0044] Studies have shown that infertility has complex pathogenesis and multiple causes. Common causes include kidney deficiency, liver stagnation, and spleen deficiency, leading to phlegm-dampness stagnation and blood stasis, resulting in malnourishment of the Chong and Ren meridians and impaired essence and blood circulation. The kidneys store essence, which is the foundation of innate constitution, while the spleen is the foundation of acquired constitution, and is closely related to the strength of kidney essence. If the spleen and stomach functions are disordered, they cannot transform qi and blood, leading to malnourishment of the liver and kidneys. If the spleen is deficient and its transportation and transformation functions are disordered, turbidity, dampness, blood stasis, and phlegm will be generated internally, leading to the formation of internal pathological products of infertility. If the ascending and descending functions of the spleen and stomach are disordered, on the one hand, it will disrupt the balance of yin and yang, qi and blood, and water and fire in the body, causing imbalance of qi in other organs; on the other hand, it will lead to insufficient intake of essence from food and water, resulting in insufficient transformation of qi and blood, insufficient Chong and Ren meridians, and lack of source of essence and blood, thus hindering conception.

[0045] Therefore, based on the pathogenesis, this invention takes tonifying the spleen and kidneys as its main treatment principle. It primarily uses Eucommia ulmoides and deer antler glue to tonify the liver and kidneys, combined with Rehmannia glutinosa, turtle shell, and wolfberry to nourish yin and kidneys. It primarily uses Citrus reticulata peel to strengthen the spleen and stomach, combined with chicken gizzard to invigorate the spleen and stomach, Atractylodes macrocephala to tonify qi and strengthen the spleen, and Adenophora stricta to nourish the stomach and generate fluids to replenish the acquired constitution. It also uses Curcuma longa, Cyperus rotundus, Bupleurum chinense, and Paeonia lactiflora to soothe the liver, relieve depression, promote qi circulation, and invigorate blood. It uses Ostrea gigas, Anemarrhena asphodeloides, and Nelumbo nucifera to strengthen the spleen, calm the mind, and consolidate essence. It uses Astragalus membranaceus and Panax ginseng to tonify qi, combined with donkey-hide gelatin to replenish blood, support the body's resistance, and eliminate pathogenic factors. It uses Paeonia suffruticosa, Prunus persica, and Angelica sinensis to invigorate blood, remove blood stasis, unblock meridians, and dredge the Chong and Ren meridians. It uses Phellodendron chinense and Tetrapanax papyriferus to clear heat, promote diuresis, and resolve phlegm. Leonurus japonicus enhances the effect of removing blood stasis.

[0046] The beneficial effects achieved by using this invention are as follows:

[0047] This invention relates to a combination of medicinal ingredients that invigorate the spleen and nourish blood, warm and tonify the liver and kidneys, nourish yin and kidneys; soothe the liver and relieve depression, promote qi and nourish blood, strengthen the middle jiao to generate qi and blood; invigorate blood and remove blood stasis, unblock the Chong and Ren meridians; and clear heat and dampness, eliminate dampness and resolve phlegm. This combination can ensure sufficient and balanced qi and blood in the liver and kidneys, and unblock the Chong and Ren meridians. It has good therapeutic effects on male and female infertility caused by various reasons, especially suitable for female infertility caused by kidney deficiency and weakness, blocked fallopian tubes, cold uterus, kidney deficiency-type ovulation disorders, obesity and blood stasis, weakness and blood deficiency, etc.; it is also suitable for male infertility caused by kidney deficiency leading to cold sperm, low sperm count, oligospermia, and necrospermia.

[0048] Furthermore, this invention can be used in conjunction with acupuncture to treat male and female infertility. Detailed Implementation

[0049] Reference will now be made to detailed embodiments of the present invention, one or more of which are described below. Each example is provided for explanation and not for limitation of the invention. In fact, it will be apparent to those skilled in the art that various modifications and variations can be made to the invention without departing from its scope or spirit. For example, features described or illustrated as part of one embodiment may be used in another embodiment to produce further embodiments.

[0050] Therefore, this invention is intended to cover such modifications and variations falling within the scope of the appended claims and their equivalents. Other objects, features, and aspects of the invention are disclosed in or will be apparent from the following detailed description. Those skilled in the art will understand that this discussion is merely a description of exemplary embodiments and is not intended to limit the broader aspects of the invention. The invention is further described below with reference to embodiments.

[0051] Example 1: A traditional Chinese medicine composition for treating infertility, comprising the following raw materials in parts by weight:

[0052] 50 parts Rehmannia glutinosa, 30 parts Paeonia lactiflora, 60 parts Trionyx sinensis, 20 parts Paeonia suffruticosa, 20 parts Prunus persica, 15 parts Ginseng, 35 parts Adenophora stricta, 40 parts Lycium barbarum, 40 parts Ostrea gigas, 30 parts Cyperus rotundus, 30 parts Curcuma longa, 30 parts Astragalus membranaceus, 50 parts Angelica sinensis, 30 parts Anemarrhena asphodeloides, 20 parts Phellodendron chinense, 15 parts Nelumbo nucifera, 50 parts Atractylodes macrocephala, 30 parts Citrus reticulata, 30 parts Chicken gizzard, 20 parts Bupleurum chinense, 20 parts Tetrapanax papyriferus, 40 parts Colla corii asini, 30 parts Eucommia ulmoides, 30 parts Deer antler glue.

[0053] This embodiment is more suitable for treating male infertility.

[0054] Example 2: A traditional Chinese medicine composition for treating infertility, comprising the following raw materials in parts by weight: 50 parts Rehmannia glutinosa, 30 parts Paeonia lactiflora, 60 parts Trionyx sinensis, 20 parts Paeonia suffruticosa, 20 parts Prunus persica, 15 parts Ginseng, 35 parts Adenophora stricta, 40 parts Lycium barbarum, 40 parts Ostrea gigas, 30 parts Cyperus rotundus, 30 parts Curcuma longa, 30 parts Astragalus membranaceus, 50 parts Angelica sinensis, 30 parts Anemarrhena asphodeloides, 20 parts Phellodendron chinense, 15 parts Nelumbo nucifera, 50 parts Atractylodes macrocephala, 30 parts Citrus reticulata, 30 parts Chicken gizzard, 20 parts Bupleurum chinense, 20 parts Tetrapanax papyriferus, 40 parts Colla corii asini, 30 parts Eucommia ulmoides, 30 parts Deer antler glue, and 20 parts Leonurus japonicus.

[0055] This embodiment is more suitable for treating female infertility.

[0056] Examples 1 and 2 can be prepared into oral tablets by adding medically acceptable excipients, with each tablet containing 1g of active drug.

[0057] Example 3:

[0058] (1) Forty-eight female patients with infertility were recruited, aged 27-45 years. All patients had been married for more than two years, had not used contraception for more than one year, and their partners had normal reproductive function. All patients were excluded from having infertility due to congenital physiological defects or malformations; or infertility due to genetic factors. Among the patients, 5 had blocked fallopian tubes, 15 had cold uterus, 7 had kidney deficiency and ovulation disorders, 12 had obesity and blood stasis, and 9 had physical weakness and blood deficiency.

[0059] The patients were treated with the tablet medication prepared in Example 2, taking 5 tablets twice daily, morning and evening, for a course of 1-2 treatments, with 3 months constituting one course. During the treatment, patients also engaged in exercise and maintained a light diet.

[0060] Therapeutic criteria:

[0061] Effective: Conception.

[0062] Invalid: Not conceived.

[0063] Treatment results (no dropout cases) are as follows:

[0064] After one course of treatment, 13 patients became pregnant, and after two courses of treatment, a total of 41 patients became pregnant, with an effectiveness rate of 85.41%.

[0065] (2) Twenty-seven infertile male patients, aged 24-42, were recruited. All patients had been married for more than two years, had not used contraception for more than one year, and their partners had normal reproductive function. Patients with congenital malformations, testicular atrophy or obstruction, etc., were excluded.

[0066] The patients were treated with the tablet medication prepared in Example 1, taking 5 tablets twice daily, morning and evening, for a course of 1-2 treatments, with 3 months constituting one course. During the treatment phase, patients also engaged in exercise and maintained a light diet.

[0067] Therapeutic criteria:

[0068] Effective: Enables the spouse to conceive.

[0069] Invalid: The spouse did not conceive.

[0070] Treatment results (dropout cases were treated as invalid transfers) are as follows:

[0071] After one course of treatment, 5 patients' spouses became pregnant. After two courses of treatment, a total of 21 patients' spouses became pregnant, with an effectiveness rate of 77.78%.

[0072] Example 4: Typical Case

[0073] The following is one example of treatment using this invention.

[0074] Case 1: Ms. Wang, 29 years old, visited the clinic on March 15, 2016, with the chief complaint of infertility after six years of marriage.

[0075] Present Illness: The patient has been married for six years and has had multiple sexual encounters, but has been unable to conceive. Various treatments have been unsuccessful. Her menstrual cycles are often delayed. She conceived after acupuncture treatment at a hospital, but there was no fetal heartbeat. Symptoms include a dark tongue with a white coating and a wiry pulse. Past Medical History: She has a history of dysmenorrhea for many years. There is no history of drug allergies. She was treated using Example 2 of this invention for a total of three months.

[0076] In September 2016, she was already pregnant, about a month along.

[0077] Case 2: Ms. Chen, 39 years old, visited the clinic on October 5, 2014, with the chief complaint of infertility after 10 years of marriage.

[0078] Present Illness: Married for 10 years, with regular sexual activity and no contraception, yet unable to conceive. She frequently experiences irritability, thirst, dizziness, palpitations, lower back pain, and weak knees, hence her visit to my clinic. Symptoms include pale complexion, red tongue with little coating, and a thready, rapid pulse.

[0079] Past medical history: No other medical history. No history of drug or food allergies.

[0080] Menstrual history: Menarche at age 12, irregular cycle and period. Menstrual flow is scanty, bright red, without clots, mild dysmenorrhea, generally with pain before menstruation. Diagnosis and syndrome differentiation: Kidney Yin deficiency, insufficient essence and blood, deficiency of the Chong and Ren meridians, unable to condense essence for conception, hence prolonged infertility; furthermore, Yin deficiency fails to restrain Yang, easily causing irritability, thirst, dizziness, palpitations, lower back pain, and weak knees. Based on the above analysis, the diagnosis is infertility due to Kidney Yin deficiency.

[0081] The patient was treated using Example 2 of the present invention. After 2 months of treatment, the symptoms of dizziness and lower back pain improved. The total treatment lasted for 4 months.

[0082] In June 2015, she was already pregnant, two months along.

[0083] Case 3: Ms. Shen, female, 25 years old, visited the clinic on March 5, 2015, chief complaint: infertility after 7 years of marriage.

[0084] Present Illness: The patient has been married for seven years and has had difficulty conceiving. She was previously diagnosed with fallopian tube blockage at the hospital. She underwent two rounds of fallopian tube recanalization treatment, including acupuncture and oral Chinese medicine, but without effect. Symptoms include cold hands and feet, a dark purple tongue with a thin white coating, and a choppy pulse.

[0085] Analysis of syndrome differentiation: The patient has internal blood stasis, obstruction of the Chong and Ren meridians, and blockage of the uterine vessels, resulting in infertility after prolonged marriage. The obstruction of the Chong and Ren meridians leads to poor blood circulation, preventing the uterus from filling as expected, hence the scanty menstrual flow, dark purple color with clots, lower abdominal pain, thin tongue coating, and a purplish-dark tongue. Based on the above analysis, the diagnosis is infertility due to blood stasis in the uterus.

[0086] The patient was treated using Example 2 of this invention for a total of three months.

[0087] In September 2015, she was pregnant, one month along.

[0088] Case 4: Ms. Zhou, 31 years old, visited the clinic on November 5, 2011, with the chief complaint of being unable to conceive after 3 years of intercourse.

[0089] Present Illness: The patient has been physically weak since childhood, with irregular eating habits. Married for three years, she has had multiple sexual encounters without conceiving. Various treatments have been ineffective, and a previous hospital examination revealed fallopian tube blockage. Symptoms include pale complexion, thin build, cold lower abdomen, frequent urination at night, and persistent lower back and knee weakness. Her tongue is pale with a white coating, and her pulse is deep and thready. Diagnosis: Given the patient's weak constitution since childhood, combined with her pale complexion, cold lower abdomen, and pale tongue with a white coating, the diagnosis is a deficiency of warmth in the Chong and Ren meridians, hindering conception.

[0090] The patient was treated using Example 2 of this invention for a total of three months. A follow-up visit in May 2012 revealed that she was over one month pregnant.

[0091] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

Claims

1. A traditional Chinese medicine composition for treating infertility, characterized in that, It is composed of the following raw materials in parts by weight: 30-50 parts Rehmannia glutinosa, 20-30 parts Paeonia lactiflora, 30-60 parts Trionyx sinensis, 20-30 parts Paeonia suffruticosa, 20-30 parts Prunus persica, 10-15 parts Panax ginseng, 20-35 parts Adenophora stricta, 30-60 parts Lycium barbarum, 30-50 parts Ostrea gigas, 20-30 parts Cyperus rotundus, 20-30 parts Curcuma longa, 20-30 parts Astragalus membranaceus, 30-50 parts Angelica sinensis, 20-30 parts Anemarrhena asphodeloides, 20-30 parts Phellodendron chinense, 15-30 parts Nelumbo nucifera, 30-50 parts Atractylodes macrocephala, 20-30 parts Citrus reticulata, 30-50 parts Chicken gizzard, 20-30 parts Bupleurum chinense, 20-30 parts Tetrapanax papyriferus, 30-50 parts Colla corii asini, 20-30 parts Eucommia ulmoides, 20-30 parts Deer antler glue.

2. The traditional Chinese medicine composition for treating infertility according to claim 1, characterized in that, It also includes 20-30 parts of motherwort.

3. The traditional Chinese medicine composition for treating infertility according to claim 1, characterized in that, The traditional Chinese medicine composition is composed of the following raw materials in parts by weight: 50 parts Rehmannia glutinosa, 30 parts Paeonia lactiflora, 60 parts Trionyx sinensis, 20 parts Paeonia suffruticosa, 20 parts Prunus persica, 15 parts Ginseng, 35 parts Adenophora stricta, 40 parts Lycium barbarum, 40 parts Ostrea gigas, 30 parts Cyperus rotundus, 30 parts Curcuma longa, 30 parts Astragalus membranaceus, 50 parts Angelica sinensis, 30 parts Anemarrhena asphodeloides, 20 parts Phellodendron chinense, 15 parts Nelumbo nucifera, 50 parts Atractylodes macrocephala, 30 parts Citrus reticulata, 30 parts Chicken gizzard, 20 parts Bupleurum chinense, 20 parts Tetrapanax papyriferus, 40 parts Colla corii asini, 30 parts Eucommia ulmoides, 30 parts Deer antler glue.

4. A traditional Chinese medicine composition for treating infertility according to claim 2, characterized in that, The traditional Chinese medicine composition consists of the following raw materials in parts by weight: 50 parts Rehmannia glutinosa, 30 parts Paeonia lactiflora, 60 parts Trionyx sinensis, 20 parts Paeonia suffruticosa, 20 parts Prunus persica, 15 parts Ginseng, 35 parts Adenophora stricta, 40 parts Lycium barbarum, 40 parts Ostrea gigas, 30 parts Cyperus rotundus, 30 parts Curcuma longa, 30 parts Astragalus membranaceus, 50 parts Angelica sinensis, 30 parts Anemarrhena asphodeloides, 20 parts Phellodendron chinense, 15 parts Nelumbo nucifera, 50 parts Atractylodes macrocephala, 30 parts Citrus reticulata, 30 parts Chicken gizzard, 20 parts Bupleurum chinense, 20 parts Tetrapanax papyriferus, 40 parts Colla corii asini, 30 parts Eucommia ulmoides, 30 parts Deer antler glue, 20 parts Leonurus japonicus.

5. A drug for treating male infertility, characterized in that, It is made from the traditional Chinese medicine composition as described in claim 1 or 3.

6. A drug for treating male infertility according to claim 5, characterized in that, The drug is an oral medication.

7. A drug for treating female infertility, characterized in that, It is made from the traditional Chinese medicine composition according to any one of claims 1 to 4.

8. A medicine for treating female infertility according to claim 7, characterized in that, The drug is an oral medication.