A dendrobium compound product based on the theory of compatibility between medicine and food and a preparation method thereof

Abstract

The application discloses a kind of based on medicine and food homology dendrobium compound product and preparation method thereof, belong to food technical field, wherein, a kind of based on medicine and food homology dendrobium compound product, including following weight parts raw materials Effective component and pharmaceutically acceptable adjuvant: dendrobium 20-40 parts, medlar 15-25 parts, American ginseng 25-35 parts, ganoderma 15-25 parts, D-mannitol 10-20 parts.The application will dendrobium, American ginseng, ganoderma, medlar four medicinal materials scientific compatibility, wherein dendrobium nourishing yin is monarch, American ginseng yin and qi double supplementation is minister, ganoderma is right and solid foundation, medlar nourishing liver and kidney is make, follow the theory of "monarch, minister, right and solid foundation, make" of traditional Chinese medicine.Four drugs are used together, and the effect of common yin, enhancing immunity, relieving fatigue is played, and the common problem of modern people's complex sub-health is solved, and the effect is more comprehensive and balanced than single formula product.

Description

Technical Field

[0001] This invention belongs to the field of food technology, specifically relating to a compound product of Dendrobium officinale based on the principle of being both food and medicine, and its preparation method. Background Technology

[0002] With the fast pace of modern life, the number of people in a sub-healthy state is increasing, generally manifesting as low immunity, easy fatigue, and symptoms of Qi and Yin deficiency as described in Traditional Chinese Medicine, such as dry mouth and throat, and general weakness. Developing foods with clearly defined health benefits using medicinal herbs that are also food is an important direction for meeting current health needs.

[0003] Dendrobium officinale, American ginseng, Ganoderma lucidum, and wolfberry are all traditional tonic herbs. Dendrobium officinale benefits the stomach and promotes the production of body fluids, nourishes yin and clears heat; American ginseng replenishes qi and nourishes yin, clears heat and promotes the production of body fluids; Ganoderma lucidum replenishes qi and calms the mind, strengthens the body's resistance; and wolfberry nourishes the liver and kidneys, benefits essence and improves eyesight. Existing technologies already include some health products containing some of these ingredients. For example, Dendrobium officinale capsules, with Dendrobium officinale and American ginseng as the main ingredients, are used for symptoms related to qi and yin deficiency; or capsules with Dendrobium officinale, American ginseng, and yam as ingredients are claimed to have the health function of "enhancing immunity." In addition, there are products on the market such as "Senyama Dendrobium officinale Granules," whose formulations differ from this application, for example, containing Ophiopogon japonicus and Polygonatum odoratum instead of Ganoderma lucidum and wolfberry.

[0004] However, existing products mostly consist of simple combinations of two medicinal herbs, such as Dendrobium officinale with American ginseng, or have a single therapeutic effect, making it difficult to comprehensively address the complex sub-health conditions. Furthermore, they are primarily available in capsules and granules, lacking more convenient and palatable modern dosage forms such as flavored beverages and lozenges, which limits their application in different lifestyle scenarios.

[0005] Therefore, in order to address the above-mentioned technical problems, it is necessary to provide a compound product of Dendrobium officinale based on the principle of being both food and medicine, and its preparation method.

[0006] The information disclosed in this background section is intended only to enhance the understanding of the overall background of the invention and should not be construed as an admission or in any way implying that the information constitutes prior art known to those skilled in the art. Summary of the Invention

[0007] The purpose of this invention is to provide a compound product based on Dendrobium officinale, a food and medicine homology ingredient, which has comprehensive health benefits including invigorating qi and nourishing yin, enhancing immunity, and relieving fatigue. This compound product has multiple dosage forms and stable processing methods that effectively preserve active ingredients and improve product taste.

[0008] To achieve the above objectives, a specific embodiment of the present invention provides the following technical solution: A compound product based on Dendrobium officinale, a food and medicine homology ingredient, comprises the following active ingredients and pharmaceutically acceptable excipients in parts by weight: 20-40 parts Dendrobium officinale, 15-25 parts Lycium barbarum, 25-35 parts American ginseng, 15-25 parts Ganoderma lucidum, and 10-20 parts D-mannitol.

[0009] In one or more embodiments of the present invention, the raw materials are in the following weight parts: 30 parts Dendrobium officinale, 20 parts Lycium barbarum, 30 parts American ginseng, 20 parts Ganoderma lucidum, and 15 parts D-mannitol.

[0010] In one or more embodiments of the present invention, the pharmaceutically acceptable excipients include one or more of fillers, flavoring agents, lubricants, binders, disintegrants, beverage bases, or confectionery bases.

[0011] In one or more embodiments of the present invention, the lubricant is magnesium stearate.

[0012] In one or more embodiments of the present invention, the dosage form of the compound product is granules, solid beverage, tablets, hard capsules, soft capsules, candy, or oral liquid.

[0013] A method for preparing the aforementioned compound product based on Dendrobium officinale, which is both a food and a medicine, includes the following steps: S1. Extraction: Mix Dendrobium officinale, American ginseng, Ganoderma lucidum and wolfberry raw materials, extract with water, filter to obtain extract; S2. Concentration: The extract is concentrated to obtain a thick paste; S3. Forming: The paste is mixed with D-mannitol and necessary pharmaceutically acceptable excipients to form the target dosage form.

[0014] In one or more embodiments of the present invention, in step S1, the water extraction is performed by boiling 2-3 times, each time for 1-3 hours.

[0015] In one or more embodiments of the present invention, in step S2, the extract is concentrated to a relative density of 1.10-1.30 at 50-60°C.

[0016] In one or more embodiments of the present invention, step S3, when preparing granules or solid beverages, includes the steps of mixing the thick paste with D-mannitol, drying, and granulating. When preparing tablets, the step of compressing the dried mixture into tablets is included; When preparing beverages, the process includes dissolving the thick paste, D-mannitol, and flavoring agent in water and then sterilizing it.

[0017] The above-mentioned compound products based on Dendrobium officinale, which is both food and medicine, are used in the preparation of health foods for enhancing immunity, relieving physical fatigue, or nourishing yin and replenishing qi.

[0018] Compared with the prior art, the beneficial effects of the present invention are as follows: This invention scientifically combines four medicinal herbs: Dendrobium officinale, American ginseng, Ganoderma lucidum, and wolfberry. Dendrobium officinale, nourishing Yin, is the principal herb; American ginseng, tonifying both Qi and Yin, is the assistant herb; Ganoderma lucidum, strengthening the body's resistance, is the adjuvant herb; and wolfberry, nourishing the liver and kidneys, is the guiding herb, following the traditional Chinese medicine theory of "principal, assistant, adjuvant, and guiding herbs." The four herbs work together to invigorate Qi and nourish Yin, enhance immunity, and relieve fatigue, specifically addressing common complex sub-health issues in modern populations. Its efficacy is more comprehensive and balanced than single-herb formulations. Furthermore, it breaks through the limitations of traditional health food products with single dosage forms. The same core formula can be adapted to various dosage forms such as granules, beverages, tablets, and candies by adjusting excipients and molding processes. For example, granules can be chosen for convenient preparation, beverages for instant thirst quenching, and tablets or candies for convenient chewing, greatly expanding the product's application scenarios and consumer base.

[0019] In addition, the addition of D-mannitol not only serves as an excellent filler and shaping agent, but also leverages its unique refreshing sweetness and ability to mask bitterness, effectively neutralizing some of the unpleasant flavors of the medicinal herbs. Combined with other natural flavoring agents, the final product has a refreshing and slightly sweet taste that is easily accepted, increasing consumers' willingness to consume it long-term.

[0020] This invention employs a water extraction process, which can fully extract water-soluble active ingredients such as polysaccharides and saponins from raw materials. Combined with modern drying technology, it is beneficial for the preservation of heat-sensitive components and the long-term stability of the product, and facilitates the subsequent processing of various dosage forms. Attached Figure Description

[0021] Figure 1 This is a comparative chart showing the effects of different samples on the phagocytic activity of RAW264.7 macrophages in one embodiment of the present invention; Figure 2 This is a comparative chart showing the effects of the product of the present invention on anti-fatigue related indicators in mice in one embodiment of the present invention. Detailed Implementation

[0022] To enable those skilled in the art to better understand the technical solutions in this disclosure, the technical solutions in the embodiments of this disclosure will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this disclosure, and not all embodiments. Based on the embodiments in this disclosure, all other embodiments obtained by those skilled in the art without creative effort should fall within the scope of protection of this disclosure.

[0023] Example 1: Preparation of Dendrobium officinale compound granules Ingredients: 30g Dendrobium officinale, 20g wolfberry, 30g American ginseng, 20g Ganoderma lucidum, 15g D-mannitol, 0.5g magnesium stearate, 0.2g steviol glycosides.

[0024] Preparation method: (1) Pretreatment: Wash Dendrobium officinale, American ginseng and Ganoderma lucidum, dry them at 60℃, and pulverize them through a 20-mesh sieve to obtain coarse powder. Wash wolfberry and drain.

[0025] (2) Extraction: Mix the above three coarse powders with wolfberry, add purified water at 10 times the total weight of the medicinal materials, and heat under reflux for extraction twice, 1.5 hours each time. Combine the extracts and filter through a 200-mesh sieve.

[0026] (3) Concentration: The filtrate was concentrated under reduced pressure at 65℃ and -0.08MPa to obtain a thick extract with a relative density of 1.20 at 60℃.

[0027] (4) Mixing and drying: The thick extract, D-mannitol, and steviol glycosides are placed in a mixer and stirred thoroughly. The mixture is then sent to a spray drying tower for drying to obtain a dry fine powder. The inlet temperature of the spray drying tower is 175±5℃, and the outlet temperature is 85±5℃.

[0028] (5) Granulation and granulation: Add magnesium stearate to the dry fine powder, mix evenly, and then granulate using a dry granulation machine.

[0029] (6) Packaging: Pack the granules into aluminum foil bags, 10g per bag, and seal.

[0030] This product consists of light brown to brownish-brown granules; it has a slightly fragrant odor, a sweet and slightly bitter taste, and a cooling sensation.

[0031] Example 2: Preparation of Dendrobium officinale compound beverage Ingredients: 30g Dendrobium officinale, 20g wolfberry, 30g American ginseng, 20g Ganoderma lucidum, 15g D-mannitol, 5g fructose syrup, 0.05g sucralose, 0.3g citric acid, and purified water to 1000mL.

[0032] Preparation method: (1) Extraction and concentration: Same as steps (1)-(3) in Example 1, to obtain a thick extract.

[0033] (2) Preparation: Transfer the thick extract to a preparation tank, add D-mannitol, fructose syrup, sucralose, citric acid, and an appropriate amount of purified water and stir until completely dissolved.

[0034] (3) Volume adjustment and fine filtration: Add purified water to a volume of 1000 mL and then finely filter through a 0.45 μm microporous membrane.

[0035] (4) Sterilization and filling: After the filtrate is sterilized at 135°C for 5 seconds, it is cooled to 85°C and filled into 250mL PET bottles under aseptic conditions and then sealed with screw caps.

[0036] This product is a clear, brownish-yellow liquid; it has a refreshing, sweet taste with a slight sourness and a unique herbal flavor, without any obvious bitterness.

[0037] Example 3: Preparation of Dendrobium officinale compound compressed candy Ingredients: 30g Dendrobium officinale, 20g wolfberry, 30g American ginseng, 20g Ganoderma lucidum, 15g D-mannitol, 35g sorbitol, 10g microcrystalline cellulose, 1g magnesium stearate, 0.1g menthol.

[0038] Preparation method: (1) Extraction and drying: Same as steps (1)-(4) in Example 1, to obtain dried fine powder.

[0039] (2) General mixing: Place the dried fine powder, sorbitol, microcrystalline cellulose and menthol in a three-dimensional mixer and mix for 20 minutes. Add magnesium stearate and continue mixing for 5 minutes.

[0040] (3) Tableting: The uniformly mixed powder is compressed into round tablets with a diameter of 10 mm, a tablet weight of 0.8 g, and a hardness of 5-7 kg using a rotary tablet press.

[0041] (4) Packaging: After compression, the tablets are packaged in blister packs or bottles.

[0042] This product is a light brown, irregularly shaped tablet; it has a sweet and cool taste when held in the mouth or chewed, with a moderate mouthfeel.

[0043] To demonstrate the superiority of the formulation and process of this invention, the following comparative examples are provided.

[0044] Comparative Example 1 (lacking D-mannitol) Except for the absence of D-mannitol and any other flavoring agents, the formulation and preparation process are the same as in Example 1. The resulting product has a very pronounced bitter taste, making it almost impossible to consume directly, and its market acceptance is extremely low.

[0045] Comparative Example 2 (using sucrose instead of D-mannitol) In Example 1, D-mannitol was replaced with an equal amount of sucrose, while other processes remained unchanged. The resulting granules had a cloyingly sweet taste and were prone to caramelization during spray drying, resulting in a darker product color, extremely high hygroscopicity, clumping after one week of storage, and poor stability.

[0046] Comparative Example 3 (Dendrobium officinale and American ginseng only) Take 30g of Dendrobium officinale and 30g of American ginseng, and prepare granules according to the method in Example 1. Although this product has a certain effect of nourishing yin and replenishing qi, it has a monotonous taste and lacks the immune-regulating and synergistic nourishing effects of Ganoderma lucidum and wolfberry.

[0047] Comparative Example 4 (Changing the core ratio) The core formula was changed to: 50g Dendrobium officinale, 10g Lycium barbarum, 10g American ginseng, 10g Ganoderma lucidum, and 15g D-mannitol. The proportion of Dendrobium officinale in this formula is too high, resulting in an overly cold nature and flavor in the product. Furthermore, its overall efficacy leans towards nourishing Yin, and its effect of tonifying Qi and strengthening the body is significantly weaker than the balanced formula of this invention, failing to meet the design goal of simultaneously nourishing both Qi and Yin.

[0048] The following cell and animal experiments verify the health benefits of the product of this invention.

[0049] Experimental Example 1: Macrophage Phagocytosis Assay - Preliminary Study on Immunomodulatory Effects Sample preparation: Take the granule samples prepared in Example 1, Comparative Example 3, and Comparative Example 4, and physiological saline as a blank control group, and prepare a test solution of 1 mg / mL with cell culture medium, and filter it aseptically for later use.

[0050] Experimental Methods: A mouse mononuclear macrophage RAW264.7 model was used. Cells were divided into 5 groups: blank control group, positive control group (lipopolysaccharide, LPS), Example 1 group, Comparative Example 3 group, and Comparative Example 4 group. After each group was treated with the corresponding test solution or stimulant for 24 hours, neutral red dye was added, and the phagocytic activity of macrophages was measured.

[0051] The results are shown in the table below. The sample in Example 1 significantly enhanced the phagocytic capacity of macrophages, and the effect was better than that of the other pairs, indicating that the complete formula of the present invention has significant advantages in synergistically enhancing immune function.

[0052] Table 1: Effects of different samples on the phagocytic activity of RAW264.7 macrophages

[0053] Experiment Example 2: Weight-bearing swimming experiment in mice - evaluation of the function of relieving physical fatigue Samples and animals: The granules prepared in Example 1 were formulated into solutions at low, medium, and high doses (0.15, 0.30, 0.60 g / kg). Sixty healthy male ICR mice were randomly divided into a blank control group, the low / medium / high dose groups of Example 1, comparative example 1, and comparative example 2.

[0054] Experimental methods: Mice were administered the drug by gavage for 30 consecutive days. Thirty minutes after the last administration, a weight-bearing (5% body weight) swimming test was conducted, and the time taken for the mice to swim to exhaustion was recorded. Blood was collected immediately after swimming to detect the levels of blood lactate (BLA) and serum urea nitrogen (SUN); the mice were sacrificed, and their livers were harvested to determine the liver glycogen content.

[0055] The results are shown in the table below. Compared with the blank control group, the medium and high dose groups in Example 1 significantly prolonged the weight-bearing swimming time of mice, reduced the levels of blood lactate and serum urea nitrogen after exercise, and increased liver glycogen reserves, demonstrating a clear anti-fatigue effect. This overall effect is the result of the synergistic effect of the various components in the formula.

[0056] Table 2: Effects of the product of this invention on anti-fatigue related indicators in mice

[0057] This invention scientifically combines four medicinal herbs: Dendrobium officinale, American ginseng, Ganoderma lucidum, and wolfberry. Dendrobium officinale, nourishing Yin, is the principal herb; American ginseng, tonifying both Qi and Yin, is the assistant herb; Ganoderma lucidum, strengthening the body's resistance, is the adjuvant herb; and wolfberry, nourishing the liver and kidneys, is the guiding herb, following the traditional Chinese medicine theory of "principal, assistant, adjuvant, and guiding herbs." The four herbs work together to invigorate Qi and nourish Yin, enhance immunity, and relieve fatigue, specifically addressing common complex sub-health issues in modern populations. Its efficacy is more comprehensive and balanced than single-herb formulations. Furthermore, it breaks through the limitations of traditional health food products with single dosage forms. The same core formula can be adapted to various dosage forms such as granules, beverages, tablets, and candies by adjusting excipients and molding processes. For example, granules can be chosen for convenient preparation, beverages for instant thirst quenching, and tablets or candies for convenient chewing, greatly expanding the product's application scenarios and consumer base.

[0058] In addition, the addition of D-mannitol not only serves as an excellent filler and shaping agent, but also leverages its unique refreshing sweetness and ability to mask bitterness, effectively neutralizing some of the unpleasant flavors of the medicinal herbs. Combined with other natural flavoring agents, the final product has a refreshing and slightly sweet taste that is easily accepted, increasing consumers' willingness to consume it long-term.

[0059] This invention employs a water extraction process, which can fully extract water-soluble active ingredients such as polysaccharides and saponins from raw materials. Combined with modern drying technology, it is beneficial for the preservation of heat-sensitive components and the long-term stability of the product, and facilitates the subsequent processing of various dosage forms.

[0060] It will be apparent to those skilled in the art that this disclosure is not limited to the details of the exemplary embodiments described above, and that this disclosure can be implemented in other specific forms without departing from its spirit or essential characteristics. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of this disclosure is defined by the appended claims rather than the foregoing description. Thus, all variations falling within the meaning and scope of equivalents of the claims are intended to be included within this disclosure. No reference numerals in the claims should be construed as limiting the scope of the claims.

[0061] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A compound product based on Dendrobium officinale, a food and medicine homology herb, characterized in that, Includes the following active ingredients and pharmaceutically acceptable excipients in parts by weight: 20-40 parts of Dendrobium officinale, 15-25 parts of Lycium barbarum, 25-35 parts of American ginseng, 15-25 parts of Ganoderma lucidum, 10-20 parts of D-mannitol, and 0.1-1 parts of magnesium stearate.

2. The compound product based on Dendrobium officinale, a food and medicine homology, as described in claim 1, is characterized in that... The raw materials are in the following weight proportions: 30 parts Dendrobium officinale, 20 parts Lycium barbarum, 30 parts American ginseng, 20 parts Ganoderma lucidum, 15 parts D-mannitol, and 0.5 parts magnesium stearate.

3. The compound product based on Dendrobium officinale, a food and medicine homology, as described in claim 1 or 2, is characterized in that... Pharmaceutically acceptable excipients include one or more of fillers, flavoring agents, lubricants, binders, disintegrants, beverage bases, or confectionery bases.

4. The compound product based on Dendrobium officinale, a food and medicine homology, as described in claim 3, is characterized in that... The lubricant is magnesium stearate.

5. The compound product based on Dendrobium officinale (a medicinal and edible herb) according to any one of claims 1-4, characterized in that, The dosage form of the compound product is granules, solid beverage, tablets, hard capsules, soft capsules, candy, or oral liquid.

6. A method for preparing a compound product based on Dendrobium officinale (a medicinal and edible herb) as described in any one of claims 1-5, characterized in that, Includes the following steps: S1. Extraction: Mix Dendrobium officinale, American ginseng, Ganoderma lucidum and wolfberry raw materials, extract with water, filter to obtain extract; S2. Concentration: The extract is concentrated to obtain a thick paste; S3. Forming: The paste is mixed with D-mannitol and necessary pharmaceutically acceptable excipients to form the target dosage form.

7. The method for preparing a compound product based on Dendrobium officinale (a medicinal and edible herb) according to claim 6, characterized in that, In step S1, the water extraction involves boiling 2-3 times, each time for 1-3 hours.

8. The method for preparing a compound product based on Dendrobium officinale (a medicinal and edible herb) according to claim 6, characterized in that, In step S2, the extract is concentrated to a relative density of 1.10-1.30 at 50-60°C.

9. The method for preparing a compound product based on Dendrobium officinale (a medicinal and edible herb) according to claim 6, characterized in that, In step S3, when preparing granules or solid beverages, the steps include mixing the thick paste with D-mannitol, drying, and granulating. When preparing tablets, the step of compressing the dried mixture into tablets is included; When preparing beverages, the process includes dissolving the thick paste, D-mannitol, and flavoring agent in water and then sterilizing it.

10. The use of the compound product based on Dendrobium officinale, a food and medicine homology, as described in any one of claims 1-5, in the preparation of health foods for enhancing immunity, relieving physical fatigue, or nourishing yin and replenishing qi.

Images