Pharmaceutical composition for treating onychomycosis

By using ointments or solutions made from Stemona japonica, Dictamnus dasycarpus bark, and Pseudolarix amabilis bark, the psychological barriers caused by surgical nail removal and the poor efficacy of single-drug application in the treatment of onychomycosis have been resolved. This provides a highly adaptable and easy-to-use treatment plan, achieving effective treatment of onychomycosis.

CN121868423APending Publication Date: 2026-04-17DEZHOU WANGS HEALTH MANAGEMENT CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DEZHOU WANGS HEALTH MANAGEMENT CO LTD
Filing Date
2023-05-22
Publication Date
2026-04-17

AI Technical Summary

Technical Problem

Among the existing treatments for onychomycosis, surgical nail removal can cause psychological distress and nerve damage, while topical medications are ineffective and prone to recurrence, cannot be cured, and can lead to dependence with long-term use.

Method used

Using Stemona japonica, Dictamnus dasycarpus bark, and Pseudolarix amabilis bark as raw materials, the ingredients are ground into powder and mixed with petroleum jelly to make an ointment, or soaked in medical alcohol to make a solution, which is used to treat onychomycosis and can be adapted to the needs of different stages of the disease.

Benefits of technology

It provides simple and easy-to-use traditional Chinese medicine compositions, with high adaptability in ointment and liquid forms. It can effectively treat onychomycosis, reduce the risk of recurrence, avoid dependence, and is suitable for widespread use.

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Abstract

The invention discloses a pharmaceutical composition for treating onychomycosis. The pharmaceutical composition is prepared from 100g of radix stemonae, 20g of cortex dictamni and 40g of cortex pseudolaricis. The preparation method of the pharmaceutical composition for treating onychomycosis comprises the following steps: S1, purchasing medicines: directly purchasing the medicines in a traditional Chinese medicine pharmacy according to the components and quantity of the medicines; s2, processing: putting the purchased radix stemonae, cortex dictamni and cortex pseudolaricis into a small-sized steel mill, grinding and processing to form powder, then sieving with a 120-mesh sieve, and screening out fine powder to obtain processed powder; and S3, ointment preparation: taking 12-18 g of the processing powder and 6-8 g of vaseline, uniformly mixing and stirring to prepare the ointment, adopting traditional Chinese medicines as raw materials, facilitating preparation and processing, forming ointment and liquid medicine forms through different preparation methods, using the ointment and the liquid medicine in different stages and under different diseases, using the ointment and the liquid medicine in a mutually matched manner, and being simple and easy to operate, convenient to smear and use and suitable for popularization and application. Adaptability is high, and application and popularization are facilitated.
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Description

Technical Field

[0001] This invention relates to the field of onychomycosis treatment technology, and more particularly to pharmaceutical compositions for treating onychomycosis. Background Technology

[0002] Onychomycosis, also known as nail fungus, is a fungal infection caused by a large class of microorganisms called pathogenic fungi. It is characterized by thickened, blackish-gray nails, or yellowish-white spots, and loss of luster.

[0003] In the treatment of onychomycosis, current treatment methods mainly involve surgical nail removal and topical medication. However, surgical nail removal can cause fear and create significant psychological barriers for patients. Furthermore, the anesthesia administered before nail removal can damage nerves, and the condition is prone to recurrence and cannot be completely cured. On the other hand, topical medication alone is not very effective, has a long treatment period, and can lead to long-term dependence, causing great inconvenience to patients' lives. Therefore, it is necessary to propose a traditional Chinese medicine combination. Summary of the Invention

[0004] The purpose of this invention is to address the shortcomings of existing technologies by providing a pharmaceutical composition for treating onychomycosis.

[0005] To achieve the above objectives, the present invention adopts the following technical solution:

[0006] A pharmaceutical composition for treating onychomycosis, comprising 100 grams of Stemona japonica, 20 grams of Dictamnus dasycarpus root bark, and 40 grams of Pseudolarix amabilis root bark;

[0007] The preparation method of this pharmaceutical composition for treating onychomycosis includes the following steps:

[0008] S1. Purchasing medicine: Purchase directly from a traditional Chinese medicine pharmacy according to the ingredients and quantity of the medicine;

[0009] S2. Processing: Put the purchased Stemona japonica, Dictamnus dasycarpus bark, and Pseudolarix amabilis bark into a small steel mill and grind them into powder. Then, pass the powder through a 120-mesh sieve to obtain fine powder.

[0010] S3. Preparation of ointment: Take 12g to 18g of processed powder and 6g to 8g of petroleum jelly, mix and stir evenly to make ointment;

[0011] S4. Preservation: Store in a sealed container; S5. Occlusive treatment: Take a small amount of ointment with a cotton swab, 0.3 to 0.5 grams each time, apply it evenly to the affected nail, and seal with adhesive tape. Change the dressing every seven days, and continue for three to five times to complete the treatment.

[0012] Preferably, step S3 further includes preparing a solution, and includes the following steps:

[0013] A1. Put the purchased Chinese medicinal herbs into a grinder and grind them directly into coarse powder;

[0014] A2. Weigh out double the weight of medical alcohol according to the weight of the coarse powder;

[0015] A3. Pour the coarse powder into a glass bottle and soak it in medical alcohol;

[0016] A4. After seven days, filter out the coarse powder to obtain the liquid medicine, then seal and store it.

[0017] Preferably, the method of using the medicine includes the following steps:

[0018] B1. Divide the medicine into plastic bottles and seal them for storage;

[0019] B2. Pour some of the medicine into the bottle cap and dab it with a cotton swab for 5 seconds;

[0020] B3. Apply the cotton swab tip back and forth on the affected nail twice a day, with an interval of 6 to 8 hours.

[0021] B4. Apply and let it dry until the affected nail heals.

[0022] Preferably, the medication is used within the interval between the S5 occlusion treatments.

[0023] Preferably, the medicine purchased in S1 is a finished Chinese medicinal material, and all of them are dried medicinal materials.

[0024] Preferably, the grinding process in step S2 further includes first crushing the Chinese medicinal materials into small pieces and then grinding them.

[0025] Preferably, the sealing and preservation in step S4 is carried out using a plastic bottle.

[0026] The pharmaceutical composition for treating onychomycosis provided by this invention uses traditional Chinese medicine as raw material, which is convenient for preparation and processing. Moreover, it can be formed into two forms, ointment and liquid, through different preparation methods, which can be used at different stages and for different symptoms. They can also be used in combination. It is simple to operate, convenient to apply, highly adaptable, and conducive to widespread use. Detailed Implementation

[0027] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to specific embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the invention.

[0028] Example 1

[0029] A pharmaceutical composition for treating onychomycosis, comprising 100 grams of Stemona japonica, 20 grams of Dictamnus dasycarpus root bark, and 40 grams of Pseudolarix amabilis root bark;

[0030] The preparation method of this pharmaceutical composition for treating onychomycosis includes the following steps:

[0031] S1. Purchasing medicine: Purchase directly from a traditional Chinese medicine pharmacy according to the ingredients and quantity of the medicine;

[0032] S2. Processing: Put the purchased Stemona japonica, Dictamnus dasycarpus bark, and Pseudolarix amabilis bark into a small steel mill and grind them into powder. Then, pass the powder through a 120-mesh sieve to obtain fine powder.

[0033] S3. Preparation of ointment: Take 12g of processed powder and 6g of petroleum jelly, mix and stir evenly to make ointment;

[0034] S4. Storage: Store in a sealed container;

[0035] S5. Occlusive treatment: Take a small amount of ointment with a cotton swab, 0.3 to 0.5 grams each time, apply it evenly to the affected nail, and cover with adhesive tape. Change the dressing every seven days, and continue for three to five times to complete the treatment.

[0036] Preferably, step S3 further includes preparing a solution, and includes the following steps:

[0037] A1. Put the purchased Chinese medicinal herbs into a grinder and grind them directly into coarse powder;

[0038] A2. Weigh out double the weight of medical alcohol according to the weight of the coarse powder;

[0039] A3. Pour the coarse powder into a glass bottle and soak it in medical alcohol;

[0040] A4. After seven days, filter out the coarse powder to obtain the liquid medicine, then seal and store it.

[0041] Preferably, the method of using the medicine includes the following steps:

[0042] B1. Divide the medicine into plastic bottles and seal them for storage;

[0043] B2. Pour some of the medicine into the bottle cap and dab it with a cotton swab for 5 seconds;

[0044] B3. Apply the cotton swab tip back and forth on the affected nail twice a day, with an interval of 6 to 8 hours.

[0045] B4. Apply and let it dry until the affected nail heals.

[0046] Preferably, the medication is used within the interval between the S5 occlusion treatments.

[0047] Preferably, the medicine purchased in S1 is a finished Chinese medicinal material, and all of them are dried medicinal materials.

[0048] Preferably, the grinding process in step S2 further includes first crushing the Chinese medicinal materials into small pieces and then grinding them.

[0049] Preferably, the sealing and preservation in step S4 is carried out using a plastic bottle.

[0050] The pharmaceutical composition for treating onychomycosis provided by this invention uses traditional Chinese medicine as raw material, which is convenient for preparation and processing. Moreover, it can be formed into two forms, ointment and liquid, through different preparation methods, which can be used at different stages and for different symptoms. They can also be used in combination. It is simple to operate, convenient to apply, highly adaptable, and conducive to widespread use.

[0051] Example 2

[0052] A pharmaceutical composition for treating onychomycosis, comprising 100 grams of Stemona japonica, 20 grams of Dictamnus dasycarpus root bark, and 40 grams of Pseudolarix amabilis root bark;

[0053] The preparation method of this pharmaceutical composition for treating onychomycosis includes the following steps:

[0054] S1. Purchasing medicine: Purchase directly from a traditional Chinese medicine pharmacy according to the ingredients and quantity of the medicine;

[0055] S2. Processing: Put the purchased Stemona japonica, Dictamnus dasycarpus bark, and Pseudolarix amabilis bark into a small steel mill and grind them into powder. Then, pass the powder through a 120-mesh sieve to obtain fine powder.

[0056] S3. Preparation of ointment: Take 15g of processed powder and 7g of petroleum jelly, mix and stir evenly to make ointment;

[0057] S4. Storage: Store in a sealed container;

[0058] S5. Occlusive treatment: Take a small amount of ointment with a cotton swab, 0.3 to 0.5 grams each time, apply it evenly to the affected nail, and cover with adhesive tape. Change the dressing every seven days, and continue for three to five times to complete the treatment.

[0059] Preferably, step S3 further includes preparing a solution, and includes the following steps:

[0060] A1. Put the purchased Chinese medicinal herbs into a grinder and grind them directly into coarse powder;

[0061] A2. Weigh out double the weight of medical alcohol according to the weight of the coarse powder;

[0062] A3. Pour the coarse powder into a glass bottle and soak it in medical alcohol;

[0063] A4. After seven days, filter out the coarse powder to obtain the liquid medicine, then seal and store it.

[0064] Preferably, the method of using the medicine includes the following steps:

[0065] B1. Divide the medicine into plastic bottles and seal them for storage;

[0066] B2. Pour some of the medicine into the bottle cap and dab it with a cotton swab for 5 seconds;

[0067] B3. Apply the cotton swab tip back and forth on the affected nail twice a day, with an interval of 6 to 8 hours.

[0068] B4. Apply and let it dry until the affected nail heals.

[0069] Preferably, the medication is used within the interval between the S5 occlusion treatments.

[0070] Preferably, the medicine purchased in S1 is a finished Chinese medicinal material, and all of them are dried medicinal materials.

[0071] Preferably, the grinding process in step S2 further includes first crushing the Chinese medicinal materials into small pieces and then grinding them.

[0072] Preferably, the sealing and preservation in step S4 is carried out using a plastic bottle.

[0073] Example 3

[0074] A pharmaceutical composition for treating onychomycosis, comprising 120 grams of Stemona japonica, 25 grams of Dictamnus dasycarpus root bark, and 45 grams of Pseudolarix amabilis root bark;

[0075] The preparation method of this pharmaceutical composition for treating onychomycosis includes the following steps:

[0076] S1. Purchasing medicine: Purchase directly from a traditional Chinese medicine pharmacy according to the ingredients and quantity of the medicine;

[0077] S2. Processing: Put the purchased Stemona japonica, Dictamnus dasycarpus bark, and Pseudolarix amabilis bark into a small steel mill and grind them into powder. Then, pass the powder through a 120-mesh sieve to obtain fine powder.

[0078] S3. Preparation of ointment: Take 18g of processed powder and 8g of petroleum jelly, mix and stir evenly to make ointment;

[0079] S4. Storage: Store in a sealed container;

[0080] S5. Occlusive treatment: Take a small amount of ointment with a cotton swab, 0.3 to 0.5 grams each time, apply it evenly to the affected nail, and cover with adhesive tape. Change the dressing every seven days, and continue for three to five times to complete the treatment.

[0081] Preferably, step S3 further includes preparing a solution, and includes the following steps:

[0082] A1. Put the purchased Chinese medicinal herbs into a grinder and grind them directly into coarse powder;

[0083] A2. Weigh out double the weight of medical alcohol according to the weight of the coarse powder;

[0084] A3. Pour the coarse powder into a glass bottle and soak it in medical alcohol;

[0085] A4. After seven days, filter out the coarse powder to obtain the liquid medicine, then seal and store it.

[0086] Preferably, the method of using the medicine includes the following steps:

[0087] B1. Divide the medicine into plastic bottles and seal them for storage;

[0088] B2. Pour some of the medicine into the bottle cap and dab it with a cotton swab for 5 seconds;

[0089] B3. Apply the cotton swab tip back and forth on the affected nail twice a day, with an interval of 6 to 8 hours.

[0090] B4. Apply and let it dry until the affected nail heals.

[0091] Preferably, the medication is used within the interval between the S5 occlusion treatments.

[0092] Preferably, the medicine purchased in S1 is a finished Chinese medicinal material, and all of them are dried medicinal materials.

[0093] Preferably, the grinding process in step S2 further includes first crushing the Chinese medicinal materials into small pieces and then grinding them.

[0094] Preferably, the sealing and preservation in step S4 is carried out using a plastic bottle.

Claims

1. A pharmaceutical composition for the treatment of onychomadesis, characterized by: The drug composition includes 100 grams of Stemona japonica, 20 grams of Dictamnus dasycarpus root bark, and 40 grams of Pseudolarix amabilis root bark; The preparation method of this pharmaceutical composition for treating onychomycosis includes the following steps: S1. Purchasing medicine: Purchase directly from a traditional Chinese medicine pharmacy according to the ingredients and quantity of the medicine; S2. Processing: Put the purchased Stemona japonica, Dictamnus dasycarpus bark, and Pseudolarix amabilis bark into a small steel mill and grind them into powder. Then, pass the powder through a 120-mesh sieve to obtain fine powder. S3. Preparation of ointment: Take 12g to 18g of processed powder and 6g to 8g of petroleum jelly, mix and stir evenly to make ointment; S4. Storage: Store in a sealed container; S5. Occlusive treatment: Take a small amount of ointment with a cotton swab, 0.3 to 0.5 grams each time, apply it evenly to the affected nail, and cover with adhesive tape. Change the dressing every seven days, and continue for three to five times to complete the treatment.

2. The pharmaceutical composition for treating onychomycosis according to claim 1, characterized by: Step S3 further includes preparing the solution, and includes the following steps: A1. Put the purchased Chinese medicinal herbs into a grinder and grind them directly into coarse powder; A2. Weigh out double the weight of medical alcohol according to the weight of the coarse powder; A3. Pour the coarse powder into a glass bottle and soak it in medical alcohol; A4. After seven days, filter out the coarse powder to obtain the liquid medicine, then seal and store it.

3. The pharmaceutical composition for treating onychomycosis according to claim 2, characterized by: The method of using the medicine includes the following steps: B1. Divide the medicine into plastic bottles and seal them for storage; B2. Pour some of the medicine into the bottle cap and dab it with a cotton swab for 5 seconds; B3. Apply the cotton swab tip back and forth on the affected nail twice a day, with an interval of 6 to 8 hours. B4. Apply and let it dry until the affected nail heals.

4. The pharmaceutical composition for treating onychomycosis according to claim 3, characterized by: The medication is used during the interval between S5 occlusion treatments.

5. The pharmaceutical composition for treating onychomycosis according to claim 1, characterized by: The medicines purchased in S1 are finished Chinese medicinal materials, all of which are dried medicinal materials.

6. The pharmaceutical composition for treating onychomycosis according to claim 1, characterized by: The grinding process in S2 also includes first crushing the Chinese medicinal materials into small pieces and then grinding them.

7. The pharmaceutical composition for treating onychomycosis according to claim 1, characterized by: The S4 section describes the use of sealed plastic bottles for preservation.