Recombinant mouse antibody pair of targeted adenovirus DBP protein and application of recombinant mouse antibody pair in detection of various types of adenoviruses

By developing monoclonal antibody pairs targeting the adenovirus DBP protein, the problem of the difficulty in efficiently detecting multiple types of adenovirus DBP in existing technologies has been solved, achieving efficient and specific detection of multiple types of adenovirus DBP.

CN121895440AActive Publication Date: 2026-04-21INST OF PATHOGEN BIOLOGY CHINESE ACADEMY OF MEDICAL SCI
4 Cites 2 Cited by

Patent Information

Application Number
CN202610352065.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-03-20
Publication Date
2026-04-21
Estimated Expiration
2046-03-20

AI Technical Summary

Technical Problem

Existing technologies are insufficient for the efficient detection of multiple types of human adenovirus DBP, and there is a lack of effective diagnostic markers and detection methods.

Method used

A set of monoclonal antibody pairs targeting the adenovirus DBP protein was developed, consisting of capture and detection antibodies, namely monoclonal antibodies 19E3, 96-10D8, 95-2B7, 96-2C10, 96-8E10, 96-13D5 and 96-2B10, which achieve efficient detection by specifically binding to human adenovirus DBP.

Benefits of technology

It achieves efficient detection of multiple types of human adenovirus DBP, with high specificity and wide applicability, and is suitable for the detection and diagnosis of multiple types of adenovirus.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The invention provides a group of monoclonal antibody pairs targeting adenovirus DBP protein, the monoclonal antibody pairs comprise a capture antibody and a detection antibody, each of the two antibodies comprises a heavy chain variable region and a light chain variable region, the heavy chain variable region comprises heavy chain complementarity determining regions HCDR1, HCDR2 and HCDR3, the light chain variable region comprises light chain complementarity determining regions LCDR1, LCDR2 and LCDR3, and the capture antibody and the detection antibody are used for capturing and detecting the adenovirus DBP protein. Wherein the capture antibody is a monoclonal antibody 19E3; and the detection antibody is selected from a monoclonal antibody 96 to 10D8, a monoclonal antibody 95 to 2B7, a monoclonal antibody 96 to 2C10, a monoclonal antibody 96 to 8E10, a monoclonal antibody 96 to 13D5 or a monoclonal antibody 96 to 2B10. The monoclonal antibody pair disclosed by the invention can be used for efficiently detecting various types of HAdV DBP.
Need to check novelty before this filing date? Find Prior Art