Pure traditional Chinese medicine powder for treating bedsores, wounds, scalds, ulcers and suppuration as well as preparation method and application thereof

Abstract

The invention relates to the technical field of traditional Chinese medicines and discloses pure traditional Chinese medicine powder for treating bedsores, wounds, scalds, ulcers and suppuration as well as a preparation method and application of the pure traditional Chinese medicine powder. The preparation method of the pure traditional Chinese medicine powder comprises the following steps: (1) calcining alum to obtain dried alum; (2) carrying out reaction on the dried alum and pig bile, respectively and sequentially carrying out crushing treatment and sieving on a reaction product, indigo naturalis and borneol, and then mixing the obtained materials; and (3) sterilizing the mixture obtained in the step (2). The pure traditional Chinese medicine powder prepared by the method disclosed by the invention has the effects of clearing away heat and toxic materials, diminishing inflammation, sterilizing, eliminating dampness, healing sores, activating blood and promoting tissue regeneration, can be used for treating bedsores and various wounds, scalds, ulcers and suppuration, and has the advantages of quick response, no side effect and exact curative effect.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, specifically to a pure traditional Chinese medicine powder for treating bedsores, trauma, burns, ulcers, and suppuration, as well as its preparation method and application. Background Technology

[0002] Pressure ulcers are a common complication caused by prolonged pressure on local tissues, leading to persistent ischemia, hypoxia, and malnutrition, resulting in tissue ulceration and necrosis. Their treatment is characterized by difficulty in healing, susceptibility to infection, and high nursing difficulty.

[0003] Currently, there are various clinical treatment methods. Western medicine mainly uses decompression and debridement, and uses modern dressings (such as foam dressings and silver-containing dressings), negative pressure wound therapy (NPWT), and surgery. Although these methods have certain effects, they have the following limitations: (1) high cost; (2) risk of side effects (such as antibiotic resistance, silver ion toxicity, and large surgical trauma); (3) the effect is still not ideal for some chronic and difficult-to-heal wounds. Western medicine believes that bedsores, traumatic wounds, and scald ulcers with suppuration are caused by mixed bacterial infections, and mainly uses antibacterial agents, antibiotics, surgery, negative pressure wound therapy, etc. to treat them. Traditional Chinese medicine believes that bedsores, traumatic wounds, and scald ulcers with suppuration are caused by "heat toxin accumulation", and mainly uses traditional Chinese medicine to clear heat and detoxify, reduce inflammation, sterilize, remove dryness and dampness, astringe sores, promote blood circulation, and remove necrotic tissue and promote tissue regeneration.

[0004] While existing traditional Chinese medicine preparations such as Shengji San, Shengji Yuhong Gao, Zicao Gao, and Jiuyi Dan are effective in treating bedsores, their efficacy is still not ideal. Therefore, developing a novel therapeutic drug that is low-cost, highly effective, and has few side effects is of significant clinical importance. Summary of the Invention

[0005] The purpose of this invention is to overcome the problems of high production cost, poor efficacy, and significant side effects of existing drugs for treating pressure ulcers. This invention provides a pure traditional Chinese medicine powder for treating pressure ulcers, wounds, burns, and suppurating ulcers, along with its preparation method and application. The pure traditional Chinese medicine powder prepared according to the method described in this invention is fast-acting, has no side effects, and exhibits definite efficacy in treating pressure ulcers, various wounds, burns, and suppurating ulcers.

[0006] To achieve the above objectives, the present invention provides a method for preparing a pure traditional Chinese medicine powder for treating bedsores, wounds, and suppurating scald ulcers, the method comprising the following steps: (1) Calcining alum yields calcined alum; (2) The alum and pig bile are reacted, and the reaction product, indigo and borneol are crushed and sieved in sequence. The resulting materials are then mixed. (3) Sterilize the mixture obtained in step (2).

[0007] Preferably, in step (1), the calcination conditions include: a temperature of 180-250℃ and a time of 2-4h.

[0008] Preferably, in step (2), the temperature of the reaction is 60-80°C.

[0009] Preferably, in step (2), the crushing process is carried out in a crusher, and the ratio of the feed rate to the effective volume of the crusher is 0.5-1.2:3.

[0010] Preferably, in step (2), the crushing conditions include: a rotation speed of 5000-7000 r / min and a time of 10-30 min.

[0011] Preferably, in step (2), the mesh size of the sieve used in the sieving process is 100-120 mesh.

[0012] Preferably, in steps (1) and (2), the mass ratio of alum to pig bile is 1:(0.5-1.5).

[0013] Preferably, in step (2), the mass ratio of the reaction product, the indigo and the borneol is 100:(0.5-10):(0.5-5).

[0014] Preferably, in step (3), the sterilization process can be carried out by cobalt-60 irradiation and / or ultraviolet light.

[0015] Preferably, the sterilization conditions include a temperature of 15-40°C and a time of 5-20 minutes.

[0016] The second aspect of the present invention provides a pure traditional Chinese medicine powder prepared by the method described above for treating bedsores, wounds, burns, ulcers, and suppuration.

[0017] The third aspect of this invention provides the application of the pure traditional Chinese medicine powder described above in the preparation of a medicine for treating bedsores and various traumas, burns, ulcers, and suppuration.

[0018] According to the preparation method of pure traditional Chinese medicine powder described in this invention, a water-insoluble complex is formed by calcining alum and pig bile, and then compounded with indigo naturalis and borneol as excipients. During the treatment process, a synergistic effect is produced, which can make the prepared traditional Chinese medicine powder have stronger effects of clearing heat and detoxifying, anti-inflammatory, sterilizing, removing dampness, astringing sores, promoting blood circulation and tissue regeneration. It is effective in treating bedsores and various traumas, burns, ulcers and suppuration, with rapid effect and no side effects. Detailed Implementation

[0019] The following provides a detailed description of specific embodiments of the present invention. It should be understood that the specific embodiments described herein are for illustrative and explanatory purposes only and are not intended to limit the scope of the invention.

[0020] The endpoints and any values ​​of the ranges disclosed herein are not limited to the precise ranges or values, and these ranges or values ​​should be understood to include values ​​close to these ranges or values. For numerical ranges, the endpoint values ​​of the various ranges, the endpoint values ​​of the various ranges and individual point values, and individual point values ​​can be combined with each other to obtain one or more new numerical ranges, which should be considered as specifically disclosed herein.

[0021] The preparation method of the pure traditional Chinese medicine powder for treating bedsores, wounds, burns, ulcers, and suppuration according to the present invention includes the following steps: (1) Calcining alum yields calcined alum; (2) The alum and pig bile are reacted, and the reaction product, indigo and borneol are crushed and sieved in sequence. The resulting materials are then mixed. (3) Sterilize the mixture obtained in step (2).

[0022] In step (1), the calcination conditions may include: a temperature of 180-250°C and a time of 2-4 hours. Preferably, the calcination conditions include: a temperature of 200-230°C and a time of 2.5-3.5 hours. The calcination process is used to remove water of crystallization. The calcination process can be carried out using various conventional apparatuses in this technical field. The calcination process may further include: pulverizing the calcined product and then cooling it.

[0023] In step (2), the reaction temperature can be 60-80℃, preferably 65-75℃. The reaction can be carried out in an iron pot. The reaction process may also include: pulverizing the obtained reaction product and then cooling it.

[0024] In step (2), the mixing process further includes: pulverizing the indigo and then mixing it with the reaction product. The pulverization conditions may include: a temperature of 5-60℃ and a time of 10-30 minutes. The pulverization process can be carried out in a pulverizer. The specific operation method of pulverization may include: refrigerating the inner liner and blades of the pulverizer for 10-30 minutes, and then performing intermittent pulverization by starting the machine for 30-60 seconds and then stopping for 30-60 seconds.

[0025] In step (2), preferably, the pulverization process is carried out in a pulverizer, and the ratio of the feed rate to the effective volume of the pulverizer can be 0.5-1.2:3, preferably 0.8-1:3. The pulverization conditions may include: a rotation speed of 5000-7000 r / min and a time of 10-30 min. Preferably, the pulverization conditions include: a rotation speed of 5500-6500 r / min and a time of 15-25 min. The specific operation process of the pulverization may also include: placing the reaction product, indigo, and borneol in the pulverizer and intermittently pulverizing and mixing them by starting the machine for 30-60 seconds and then stopping for 30-60 seconds.

[0026] In step (2), the mesh size of the sieve used in the sieving process can be 100-150 mesh, preferably 100-130 mesh.

[0027] In step (2), the mass ratio of alum to pig bile used in steps (1) and (2) can be 1:(0.5-1.5), preferably 1:(0.8-1.2).

[0028] In step (2), the mass ratio of the reaction product, the indigo and the borneol can be 100:(0.5-10):(0.5-5), preferably 100:(1-8):(1-4).

[0029] In step (3), the sterilization process can be performed by cobalt-60 irradiation sterilization and / or ultraviolet sterilization. In the most preferred embodiment, the sterilization process is performed by ultraviolet light. The sterilization conditions may include: a temperature of 15-40°C and a time of 5-20 min. In a preferred embodiment, the sterilization conditions include: a temperature of 20-35°C and a time of 10-15 min.

[0030] In the method described in this invention, the main component of the alum is anhydrous potassium aluminum sulfate. The alum is in the form of irregular lumps or honeycomb-like agglomerates. The appearance and texture of the alum include: white color, brittle, easily broken, dull, and hygroscopic. The physicochemical identification of the alum can be carried out by at least one of aluminum salt reaction, potassium salt reaction, and sulfate reaction. In one specific embodiment, the identification method of the aluminum salt reaction includes: dissolving the powder in water, then filtering, adding sodium hydroxide test solution to the filtrate, and generating a white colloidal precipitate. In another specific embodiment, the identification method of the potassium salt reaction includes: wetting a platinum wire with hydrochloric acid, dipping it in the powder, and burning it in a colorless flame, which produces a purple flame (observable through blue cobalt glass). In another specific embodiment, the identification method of the sulfate reaction includes: dissolving the powder in water to form a solution, adding barium chloride test solution, generating a white precipitate, and the precipitate is insoluble in hydrochloric acid or nitric acid. The method for determining the content of potassium aluminum sulfate in the alum can be complexometric titration (EDTA method). The principle of the complexometric titration method is based on the presence of aluminum ions (Al) in the alum aqueous solution. 3+ In an acetate-ammonium acetate buffer solution at pH 4.3, the alum is heated to complex with excess disodium ethylenediaminetetraacetate (EDTA-2Na). The remaining EDTA is back-titrated with zinc titrant using xylenol orange as an indicator. The standard requirements for the potassium aluminum sulfate content of the alum include: the potassium aluminum sulfate content, calculated on a dried basis, shall not be less than 99% by weight. The instrumental analytical methods for detecting the alum are X-ray diffraction (XRD) and / or inductively coupled plasma optical emission spectrometry (ICP-OES / MS). X-ray diffraction can determine that the main component of the sample is anhydrous potassium aluminum sulfate through phase analysis. Inductively coupled plasma optical emission spectrometry can accurately determine the aluminum and potassium content, and then calculate the content of anhydrous potassium aluminum sulfate in the sample. The alum has the effects of astringing and healing sores, stopping bleeding and removing putrefaction. It can be used externally for eczema, wet sores, otitis media with purulent discharge, vaginal itching and leukorrhea, epistaxis, gingival bleeding, and nasal polyps. The alum described herein possesses antibacterial properties, inhibiting various bacteria such as Staphylococcus aureus, Streptococcus, and Pseudomonas aeruginosa. The mechanism of this antibacterial action involves aluminum ions causing coagulation and denaturation of bacterial proteins. The alum can bind to serum proteins, forming water-insoluble compounds that precipitate on tissue surfaces, causing capillary constriction, reducing permeability, and decreasing exudation and bleeding. Furthermore, the alum can alleviate local inflammatory responses and itching through its astringent effect.

[0031] In the method described in this invention, the porcine bile mainly contains bile acids. These bile acids can be cholic acid and / or deoxycholic acid (DOCA), and possess saponification and surface activity. The porcine bile can be detected by thin-layer chromatography (TLC). The specific detection procedure includes: using a methanol solution of porcine bile as the test sample and deoxycholic acid (DOCA) as the reference standard. Developing the sample with a developing solvent (isooctane-ethyl ether-glacial acetic acid-n-butanol-water system), spraying with sulfuric acid ethanol solution, heating until the spots are clear, and examining under ultraviolet light (365 nm). In the chromatogram of the test sample, check whether fluorescent spots of the same color appear at the corresponding positions as in the chromatogram of the reference standard. The method for determining the DOCA content in the porcine bile can be high-performance liquid chromatography (HPLC), with specific operating conditions including: using a C18 column, using methanol-water-phosphoric acid or acetonitrile-water as the mobile phase, and using an evaporative light scattering detector (ELSD) or an ultraviolet detector (low wavelength, such as 205 nm) for determination. The standard requirements for the content of porcine decholic acid in the described pig bile include: the content of porcine decholic acid, calculated on a dried basis, shall not be less than 16% by weight. The pig bile has the effects of clearing heat, moisturizing dryness, detoxifying, and relieving cough and asthma. It can be used for feverish thirst, red eyes, sore throat, jaundice, whooping cough, asthma, diarrhea, dysentery, constipation, and carbuncles and boils. The pig bile has central antitussive and bronchodilatory effects, inhibits Streptococcus pneumoniae and Mycobacterium tuberculosis, reduces inflammatory responses, promotes bile secretion, dissolves gallstones, protects liver cells, and has antipyretic and sedative effects.

[0032] In the method described in this invention, the indigo is a dried powder, lumps, or granules obtained by processing the leaves or stems of *Strobilanthes cusia* (Acanthaceae), *Polygonum tinctorium* (Polygonaceae), or *Isatis tinctoria* (Brassicaceae), mainly containing indigo and indirubin. The indigo is a dark blue powder, light in weight, easily dispersed, and appears as irregular porous lumps or granules. It can be easily crushed into fine powder by hand, has a slightly grassy odor, and a bland taste. In one specific embodiment, the physicochemical identification method of the indigo includes: taking a small amount of powder and burning it with a low flame, producing purplish-red smoke. In another specific embodiment, the physicochemical identification method of the indigo includes: taking a small amount of powder and adding nitric acid, producing bubbles and showing a brownish-red or yellowish-brown color. The indigo can be detected by thin-layer chromatography (TLC). The specific operation process of the detection includes: using indigo and indirubin reference standards as controls, performing TLC identification. In the chromatogram of the test sample, the same blue (indigo) and purplish-red (indirubin) spots should appear at the corresponding positions as in the chromatogram of the reference standards. The method for determining the indigo and indirubin content in the indigo is high-performance liquid chromatography (HPLC). Specific operating conditions include: using a C18 column, gradient elution with methanol-water as the mobile phase, and a detection wavelength generally of 290 nm (for simultaneous detection of indigo and indirubin) or 606 nm (specifically for indigo). The standard requirements for the indigo and indirubin content in the indigo are: indigo content not less than 2% by weight, and indirubin content not less than 0.13% by weight. Indigo has the effects of clearing heat and detoxifying, cooling blood and eliminating spots, and purging fire and calming convulsions. It is used for febrile diseases with rashes, hematemesis due to blood heat, chest pain with hemoptysis, oral ulcers, mumps, sore throat, and infantile convulsions. Indirubin in indigo has anti-tumor effects, showing significant efficacy against chronic myeloid leukemia and inhibiting tumor cell DNA synthesis. Indigo has inhibitory effects on Staphylococcus aureus, Bacillus anthracis, herpes simplex virus, and influenza virus, and can enhance the phagocytic function of macrophages and improve the body's immunity.

[0033] In the method described in this invention, the borneol is natural borneol and / or synthetic borneol. The natural borneol mainly contains dextrorotatory borneol. The synthetic borneol mainly contains borneol and isoborneol. The borneol appears as colorless, transparent, or white translucent flaky, brittle crystals; it has a fragrant aroma, a pungent and cool taste, and is volatile; when ignited, it produces dense smoke and a luminous flame. The physicochemical identification method for borneol includes: taking an appropriate amount of sample, adding a few drops of ethanol to dissolve it, and adding 1-2 drops of freshly prepared 0.5-1.5% (w / w) vanillin-sulfuric acid solution, which will immediately turn purple. The detection method for borneol can be gas chromatography (GC). The detection process uses a polar chromatographic column (such as PEG-20M) and a flame ionization detector. The gas chromatography method can distinguish between natural borneol (single peak) and synthetic borneol (two main peaks: borneol and isoborneol) by comparing retention times. The content standard requirements for natural borneol include: a dextrorotatory borneol content of not less than 96% (w / w) and the absence of isoborneol. The content standards for the synthetic borneol require that the content of borneol and isoborneol be no less than 55% by weight. Borneol has the effects of clearing the mind and relieving pain, and can be used for febrile delirium, convulsions, stroke with phlegm syncope, qi stagnation and sudden syncope, coma due to sudden illness, chest pain, red eyes, canker sores, sore throat, and ear discharge. Borneol can significantly increase the rate and amount of other drugs penetrating the skin and mucous membranes, has a clear inhibitory effect on experimental inflammation and pain models, inhibits some bacteria and fungi, dilates coronary arteries, increases coronary blood flow, protects against experimental cerebral ischemia, promotes the opening of the blood-brain barrier, and facilitates the entry of other drugs into the central nervous system.

[0034] In the method described in this invention, the powerful effects of alum in removing dampness, stopping bleeding, and astringing sores, combined with the heat-clearing and detoxifying effects of pig bile, the antibacterial and anti-inflammatory effects of indigo naturalis, and the heat-clearing and analgesic effects of borneol, have significant effects in controlling wound exudation, sterilizing, eliminating inflammation, and promoting granulation tissue growth.

[0035] This invention also provides a pure traditional Chinese medicine powder prepared by the above method for treating pressure ulcers, wounds, and suppurating ulcers caused by burns. Preferably, the pure traditional Chinese medicine powder is in the form of a powder. This powder can absorb wound exudate, keep the wound dry, and form a protective layer, making it very suitable for treating pressure ulcers with significant exudate at all stages, as well as various types of wounds, burns, and suppurating ulcers.

[0036] This invention also provides the application of the pure traditional Chinese medicine powder for treating bedsores, wounds, and suppurating scald ulcers in the preparation of drugs for treating bedsores and various wounds, and suppurating scald ulcers. The specific method of using the pure traditional Chinese medicine powder may include: disinfecting with chlorhexidine, cleaning the wound with physiological saline or 3% hydrogen peroxide solution to remove secretions, then using a medical cotton swab to apply the pure traditional Chinese medicine powder evenly to the wound. Contraindications for the pure traditional Chinese medicine powder include: use with caution in individuals allergic to the ingredients, pregnant women, and infants. The precautions for the pure Chinese herbal powder include: 1. For external use only, do not ingest; 2. Avoid contact with the nasal cavity, eyes, etc. If it accidentally comes into contact with mucous membranes, rinse immediately with clean water; 3. The wound will heal after application, and there may be slight pain, which will disappear in a short time, which is normal; 4. If allergic or irritating symptoms such as skin redness, itching, rash, or burning sensation occur after application, stop using the medication immediately, clean the area with saline solution to remove any remaining powder, and seek medical attention promptly if the symptoms are severe; 5. Use with caution on areas with thin skin such as the face and neck, as well as folds such as the armpits and groin, where the skin is highly sensitive; 6. For wounds with crusts, soak sterile gauze in saline solution and apply it for 5-10 minutes to soften the crusts and necrotic tissue. Gently peel off the crusts with sterile tweezers, gently pat the wound dry with sterile gauze, and then sprinkle the powder on top.

[0037] The following examples further illustrate the pure traditional Chinese medicine powder for treating bedsores, wounds, burn ulcers, and suppuration, as well as its preparation method and application, according to the present invention. The examples are implemented based on the technical solution of the present invention, providing detailed implementation methods and specific operating procedures; however, the scope of protection of the present invention is not limited to the following examples.

[0038] Unless otherwise specified, the experimental methods used in the following embodiments are conventional methods in the art. Unless otherwise specified, the experimental materials used in the following embodiments are commercially available.

[0039] Example 1 (1) Place alum (purchased from Sichuan Xinhehua Chinese Medicine Pieces Co., Ltd., the same below) in an iron pot and calcine at 200℃ for 3 hours to obtain calcined alum; test the content of potassium aluminum sulfate by complexometric titration of the obtained calcined alum, and the content of potassium aluminum sulfate is 99.5% by weight.

[0040] (2) Place the alum obtained in step (1) and freshly filtered pig bile (purchased from Changlingang Slaughterhouse, Caohe Town, Qichun County, Hubei Province, the same below) in an iron pot and calcine them at 75°C until the water is completely evaporated to obtain a complex. Crush the cooled complex and sieve it through a 100-mesh sieve. The mass ratio of alum to pig bile is 1:1. Indigo naturalis (purchased from Kangmei Pharmaceutical Co., Ltd., hereinafter the same) and borneol (purchased from Yunnan Linyuan Fragrance Co., Ltd., hereinafter the same) were placed in a grinder (the inner liner and blades were refrigerated for 20 minutes before grinding) and intermittently ground with a 60-second start-up and 60-second pause. The powder was then sieved through a 100-mesh sieve. The complex powder, indigo naturalis powder and borneol powder were then placed in the grinder at a mass ratio of 100:6:2 and ground and mixed. The feed amount was 1 / 3 of the effective volume of the grinder. The grinding and mixing were carried out intermittently with a 60-second start-up and 60-second pause. The grinding and mixing conditions included a rotation speed of 6000 r / min and a time of 20 min to obtain the mixed powder.

[0041] (3) The mixed powder obtained in step (2) is sterilized at 25°C by ultraviolet sterilization for 12 minutes to obtain pure Chinese medicine powder A1.

[0042] Example 2 (1) Place alum in an iron pot and calcine at 220°C for 3.5 h to obtain calcined alum; test the content of potassium aluminum sulfate in the obtained calcined alum by complexometric titration, and the content of potassium aluminum sulfate is 99.5% by weight.

[0043] (2) Place the alum obtained in step (1) and freshly filtered pig bile in an iron pot and calcine them at 75°C until the water is completely evaporated to obtain a complex. Crush the cooled complex and sieve it through a 100-mesh sieve. The mass ratio of alum to pig bile is 1:1.2. Place indigo and borneol in a grinder (the inner liner and blades are refrigerated for 20 min before grinding) and grind them intermittently by starting for 60 s and then stopping for 60 s. Sieve the complex powder, indigo powder and borneol powder in a mass ratio of 100:5:3 in the grinder and grind and mix them. The feed amount is 1 / 3 of the effective volume of the grinder. Grind and mix them intermittently by starting for 60 s and then stopping for 60 s. The grinding and mixing conditions include: rotation speed of 6500 r / min and time of 15 min to obtain the mixed powder.

[0044] (3) The mixed powder obtained in step (2) is sterilized at 30°C by ultraviolet sterilization for 15 minutes to obtain pure Chinese medicine powder A2.

[0045] Example 3 (1) Place alum in an iron pot and calcine at 210°C for 2.5 hours. Then crush and cool the product to obtain calcined alum. The content of potassium aluminum sulfate in the obtained calcined alum was tested by complexometric titration. The content of potassium aluminum sulfate was 99.5% by weight.

[0046] (2) Place the alum obtained in step (1) and freshly filtered pig bile in an iron pot and calcine them at 75°C until the water is completely evaporated to obtain a complex. Crush the cooled complex and sieve it through a 100-mesh sieve. The mass ratio of alum to pig bile is 1:0.8. Place indigo and borneol in a grinder (the inner liner and blades are refrigerated for 20 minutes before grinding) and grind them intermittently by starting for 60 seconds and then stopping for 60 seconds. Sieve the complex powder, indigo powder and borneol powder in a mass ratio of 100:4:4 in the grinder and grind and mix them. The feed amount is 1 / 3 of the effective volume of the grinder. Grind and mix them intermittently by starting for 60 seconds and then stopping for 60 seconds. The grinding and mixing conditions include: rotation speed of 5500 r / min and time of 15 min to obtain the mixed powder.

[0047] (3) The mixed powder obtained in step (2) is sterilized at 25°C for 15 minutes by cobalt-60 irradiation to obtain pure Chinese medicine powder A3.

[0048] Example 4 The traditional Chinese medicine preparation was prepared according to the method of Example 1, except that the mass ratio of complex powder, indigo powder and borneol powder was adjusted to 100:3:2 to obtain pure traditional Chinese medicine powder A4.

[0049] Example 1 Patient A has been bedridden for a long time and has multiple pressure ulcers, which are round or oval in shape and about 6 cm in diameter. The pressure ulcers were disinfected and cleaned with normal saline. Pure Chinese herbal powder A1 was applied to the pressure ulcers once a day, at a dosage of approximately 1 g per 10 cm². 2 The treatment lasted for 4 days, during which the bedsores healed by scabbing and did not recur.

[0050] Example 2 Patient B has been bedridden for a long time and has multiple pressure ulcers, which are round or oval in shape and about 1 cm in diameter. The pressure ulcers were disinfected and cleaned with normal saline. Pure Chinese herbal powder A2 was applied to the pressure ulcers once a day, at a dosage of approximately 0.6 g / 10 cm. 2 The treatment lasted for 2 days, and the bedsores healed by scabbing over, with no recurrence.

[0051] Example 3 Patient C suffered burns to his leg from a motorcycle exhaust pipe, with a wound approximately 5 cm in diameter. The ulcer was disinfected and cleaned with saline solution. Pure Chinese herbal powder A3 was applied to the ulcer once daily, at a dosage of approximately 1 g per 10 cm. 2 The treatment lasts for 3 days, after which the wound can scab over and heal.

[0052] Example 4 Patient D accidentally cut off a piece of skin and flesh from his finger while chopping vegetables; the wound was approximately 1 cm in size. The wound was disinfected and cleaned with saline solution. Pure Chinese herbal powder A4 was then applied to the wound once daily, at a dosage of approximately 0.5 g per 10 cm. 2 The treatment lasts for 2 days, and the wound can scab over and heal.

[0053] Clinical trial results show that the pure Chinese herbal powder of this invention restores the skin color of the wound to normal during the treatment of bedsores and various traumas, burns, ulcers, and suppuration. The wounds completely shed their scabs and heal, producing a systemic effect of rapid astringent scab formation, strong anti-inflammatory and sterilization, and tissue regeneration, resulting in a good curative effect.

[0054] The preferred embodiments of the present invention have been described in detail above; however, the present invention is not limited thereto. Within the scope of the inventive concept, various simple modifications can be made to the technical solutions of the present invention, including combinations of various technical features in any other suitable manner. These simple modifications and combinations should also be considered as the content disclosed in the present invention and are all within the protection scope of the present invention.

Claims

1. A method for preparing a pure traditional Chinese medicine powder for treating bedsores, wounds, burns, ulcers, and suppuration, characterized in that, The method includes the following steps: (1) Calcining alum yields calcined alum; (2) The alum and pig bile are reacted, and the reaction product, indigo and borneol are crushed and sieved in sequence. The resulting materials are then mixed. (3) Sterilize the mixture obtained in step (2).

2. The method according to claim 1, characterized in that, In step (1), the calcination conditions include: a temperature of 180-250℃ and a time of 2-4h.

3. The method according to claim 1, characterized in that, In step (2), the reaction temperature is 60-80℃.

4. The method according to claim 1 or 3, characterized in that, In step (2), the crushing process is carried out in a crusher, and the ratio of the feed rate to the effective volume of the crusher is 0.5-1.2:

3. Preferably, the pulverizing conditions include: a rotation speed of 5000-7000 r / min and a time of 10-30 min.

5. The method according to claim 1, 3, or 4, characterized in that, In step (2), the sieve used in the sieving process has a mesh size of 100-120.

6. The method according to claim 1, characterized in that, In steps (1) and (2), the mass ratio of alum to pig bile is 1:(0.5-1.5).

7. The method according to claim 1, characterized in that, In step (2), the mass ratio of the reaction product, the indigo and the borneol is 100:(0.5-10):(0.5-5).

8. The method according to claim 1, characterized in that, In step (3), the sterilization process can be carried out by cobalt-60 irradiation and / or ultraviolet light. Preferably, the sterilization conditions include a temperature of 15-40°C and a time of 5-20 minutes.

9. A pure traditional Chinese medicine powder for treating bedsores, wounds, burns, ulcers, and suppuration, prepared by the method according to any one of claims 1-8.

10. The use of the pure traditional Chinese medicine powder for treating bedsores, trauma, burns, ulcers, and suppuration as described in claim 9 in the preparation of a medicine for treating bedsores, various traumas, burns, ulcers, and suppuration.