Variable-frequency closed-loop transcranial ultrasonic stimulation system and control method

By combining FPGA with CORDIC algorithm and PID control in a dual closed-loop system, the problems of frequency drift, sound intensity instability and depth adjustment rigidity in transcranial ultrasound stimulation system are solved, achieving efficient and safe neuromodulation.

CN121911037APending Publication Date: 2026-04-24FUDAN UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FUDAN UNIVERSITY
Filing Date
2026-01-22
Publication Date
2026-04-24

AI Technical Summary

Technical Problem

Existing transcranial ultrasound stimulation systems face problems such as transducer resonant frequency thermal drift and lockout, contradiction between real-time performance and accuracy of frequency tracking algorithms, unstable sound intensity control, and rigid stimulation depth adjustment, resulting in low efficiency and insufficient safety in clinical applications.

Method used

By employing FPGA and CORDIC algorithm combined with PID control strategy, dual closed-loop control of frequency and sound intensity is achieved. With the help of adjustable water bladder coupling collimator, real-time frequency locking and stable sound intensity output are realized, and the stimulation depth can be flexibly adjusted.

Benefits of technology

It achieves millisecond-level frequency tracking accuracy, stable sound intensity output, and flexible stimulation depth adjustment, improving the system's response speed and safety while reducing equipment costs and operational complexity.

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Abstract

The invention relates to the technical field of biomedical engineering and ultrasonic stimulation, and provides a variable-frequency closed-loop transcranial ultrasonic stimulation system, which comprises an upper computer control module for configuring ultrasonic stimulation parameters and generating a control instruction; the ultrasonic circuit is composed of a power supply module, an FPGA control module, an ultrasonic driving circuit module, an impedance matching module and a sampling circuit module, receives an instruction signal from the upper computer control module, generates a high-voltage driving signal of a corresponding parameter according to an instruction and performs closed-loop adjustment; the ultrasonic transducer is connected with the ultrasonic driving circuit module and converts the electric signals into ultrasonic waves; the water bag coupling collimator is arranged at the output end of the ultrasonic transducer in a sleeving mode and used for ultrasonic coupling and adjusting the depth of a stimulation focus by adjusting the liquid filling amount or the water pressure of the water bag to change the distance between the transducer and a stimulation target. The FPGA is used as a core controller, high-precision phase detection and frequency closed loop are realized by combining a CORDIC algorithm and a PID control strategy, and constant output of sound intensity and flexible adjustment of stimulation depth are realized.
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