Medicine mixing and preparing device
The multi-stage mixing and modulation mechanism of the drug mixing and modulation device enables the rotation and reciprocating oscillation of the drug modulation bottle, combined with stirring and mixing, which solves the problem of insufficient drug mixing uniformity, improves mixing efficiency and applicability, and reduces equipment costs.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- THE OBSTETRICS & GYNECOLOGY HOSPITAL OF FUDAN UNIV
- Filing Date
- 2026-01-31
- Publication Date
- 2026-04-24
AI Technical Summary
Existing drug preparation devices suffer from insufficient mixing uniformity and low drug preparation efficiency, especially in the mixing of high-viscosity and multi-component drugs, where the concentration of the drug solution becomes unbalanced, leading to prolonged mixing time.
Design a drug mixing and preparation device that employs a multi-stage mixing and preparation mechanism, including a rotary mixing driver, a dual mixing and preparation frame, and an oscillating mixing drive assembly. By rotating and oscillating the drug preparation bottle, combined with a stirring and mixing assembly, a triple mixing mechanism of rotary mixing, oscillating mixing, and stirring mixing of the drug is achieved.
It significantly improves the uniformity and efficiency of drug mixing, is applicable to drugs of different specifications, reduces equipment costs, simplifies the cleaning and disinfection process, and avoids drug residues and cross-contamination.
Smart Images
Figure CN121911279A_ABST
Abstract
Description
Technical Field
[0001] This invention belongs to the field of medical device technology, specifically relating to a drug mixing and preparation device. Background Technology
[0002] Intravenous drug preparation refers to the process by which pharmacists, technicians, or trained nurses prepare intravenous medications such as parenteral nutrition drugs, antibiotics, and antitumor drugs in a clean environment according to established procedures. Most intravenous infusions consist of multi-component mixtures, some of which have high viscosity and poor compatibility between components. Therefore, efficient mixing is necessary to achieve uniform dispersion and prevent localized concentration imbalances that could reduce efficacy or cause adverse reactions. Currently, the main preparation devices for intravenous drugs are single rotary stirrers and magnetic stirrers, widely used in outpatient pharmacies, inpatient pharmacies, and clinical departments for temporary drug preparation. Their core requirements are to improve mixing efficiency and uniformity while ensuring ease of operation, adapting to different drug specifications, facilitating cleaning and disinfection, and meeting the dual needs of clinical batch preparation and individualized formulation.
[0003] Patent CN215654993U discloses a mixing mechanism for poorly soluble drugs used in intravenous medication preparation. The mechanism includes a fixed frame, a swing platform at the front, and a swing drive mechanism at the rear. A drive shaft is located at the front of the swing drive mechanism. The front end of the drive shaft passes through the fixed frame and is fixed to the swing platform, driving the swing platform to swing back and forth. In use, the swing drive mechanism converts the continuous rotational power into the power of left-right reciprocating swing, causing the swing platform to rotate the medicine bottle left and right, thereby mixing the drug and liquid inside the bottle.
[0004] However, the above-mentioned technical solution uses the bottom of the medicine bottle as the center to swing left and right to mix the medicine in the bottle. Therefore, the swing range of the bottom of the medicine bottle is much smaller than that of the top of the medicine bottle. As a result, the degree of mixing of the medicine at the bottom of the medicine bottle is much lower than that of the medicine at the top of the medicine bottle, resulting in an imbalance of concentration and insufficient mixing uniformity. Thus, in actual use, medical staff need to prolong the stirring time, resulting in low preparation efficiency. Summary of the Invention
[0005] The purpose of this invention is to overcome the problems of insufficient mixing uniformity and low drug preparation efficiency in existing drug preparation devices.
[0006] To achieve the above objectives, the technical approach adopted by this invention is as follows: A drug mixing and preparation device is provided, comprising a base, a drug preparation bottle, and a multi-stage mixing and preparation mechanism; the multi-stage mixing and preparation mechanism is disposed on the base and detachably connected to the drug preparation bottle. This invention, through the multi-stage mixing and preparation mechanism, drives the drug preparation bottle to rotate while simultaneously causing both ends of the bottle to swing up and down reciprocally, forming a dual drug mixing mechanism, thereby improving mixing uniformity and efficiency.
[0007] Based on the above technical concept, the technical solution adopted by this invention is as follows: A drug mixing and preparation device includes a base and further includes: The medicine preparation bottle is located above the base; A multi-stage mixing and preparation mechanism is mounted on the base and detachably connected to the medicine preparation bottle. It is used to simultaneously perform rotational mixing and oscillating mixing of various medicines in the medicine preparation bottle.
[0008] To achieve a dual-drug mixing mechanism and improve the mixing uniformity and efficiency of the drugs, in the above technical solution, preferably, the multiple mixing and modulation mechanism includes: A rotary mixing driver is vertically mounted on a base, with its output end extending out of the base and positioned above it. A dual mixing and modulation rack is located on the output end of the rotary mixing driver and is detachably connected to the drug mixing bottle; The oscillating mixing drive assembly is connected to the base and the medicine preparation bottle, respectively.
[0009] To facilitate compatibility with pharmaceutical preparation bottles of different sizes, the dual mixing and preparation rack further includes: The rotating frame, which has a Y-shaped structure, is connected to the output end of the rotary mixing driver; The swing frame is mounted on the rotating frame and engages with the medicine preparation bottle.
[0010] To further define the above technical solution for securing the drug preparation bottle, the swing frame includes: The swing frame body is connected to the rotating frame at both ends by connecting rods, and the middle position of the swing frame body is engaged with the medicine preparation bottle; Two rollers are respectively located at both ends of the swing frame body and are in contact with the medicine preparation bottle.
[0011] To further refine the above technical solution by enabling the medicine preparation bottle to automatically oscillate up and down while rotating, the oscillation mixing drive component includes: Two first magnets are symmetrically arranged on the base, centered on the dual-mixing modulation frame; Two second magnets are symmetrically arranged on the base and perpendicular to the two first fixed magnets; the second magnets and the first magnets are magnetically repulsive. The third magnet is located at one end of the medicine preparation bottle and is magnetically connected to the first magnet; The fourth magnet is located at the other end of the medicine preparation bottle and is magnetically connected to the second magnet.
[0012] To avoid interference between adjacent magnets and maintain magnetic pole stability, the above technical solution is further specified by providing a partition plate between each first magnet and each adjacent second magnet.
[0013] In order to avoid interference between adjacent magnets, maintain magnetic pole stability, buffer the impact of magnetic pole switching, and balance the operational stability of the device with the hybrid power efficiency, the above technical solution is further specified: each partition plate is a T-shaped structure, and one corner of the upper surface of the partition plate is chamfered.
[0014] To facilitate thorough sterilization of medicine preparation bottles, avoid incomplete cleaning, and improve the efficiency of cleaning and sterilization, the above technical solution is further specified, and the medicine preparation bottle includes: The bottle body has a cylindrical structure and is detachably connected to the multiple mixing and modulation mechanism; Two end caps are respectively located at both ends of the bottle body and are detachably connected to the bottle body; Two limiting cylinders are located on the side of the bottle, and each limiting cylinder is used to connect to the multi-mixing and modulation mechanism.
[0015] To further improve the mixing effect of the drug solution inside the drug preparation bottle and achieve a triple mixing mechanism, the above technical solution is further specified, and the multi-mixing preparation mechanism also includes a stirring and mixing component; the stirring and mixing component includes: The guide rod is located inside the bottle and is connected to either end cap. The stirring wheel is slidably mounted on the guide rod. Beneficial effects
[0016] I. This invention, through the combined design of a drug preparation bottle and a multi-stage mixing mechanism, can mix various drugs in the drug preparation bottle from two dimensions: rotational mixing and oscillating mixing. This breaks the limitations of single stirring, improves the uniformity of drug mixing and the efficiency of preparation, and shortens the stirring time. It is especially suitable for the preparation of complex drugs with high viscosity and multiple components. Second, the present invention, through the setting of the double mixing and preparation frame, can not only realize the rotation of the medicine preparation bottle, but also make both ends of the medicine preparation bottle swing up and down while rotating. The structure is simple and easy to use. Moreover, the double mixing and preparation frame can be matched and applied to medicine preparation bottles of different sizes and specifications, thereby improving the applicability of the overall device and reducing the overall equipment manufacturing cost. Third, through the combined design of the oscillating mixing drive component, the rotary mixing driver and the stirring mixing component, this invention can mix various drugs in the drug preparation bottle from three dimensions: rotary mixing, oscillating mixing and stirring mixing, to achieve a triple mixing mechanism for drugs, and further improve the mixing uniformity and efficiency of drug preparation. Fourth, the present invention, through the combined design of the swing frame body and rollers, can realize the quick assembly and disassembly of medicine preparation bottles, which is simple and quick to operate, and can ensure that the medicine preparation bottles will not loosen during the synchronous rotation of the rotating frame. V. This invention, through the combined design of the first magnet, the second magnet, the third magnet, the fourth magnet and the medicine preparation bottle, can utilize the repulsive force between like magnets and the attractive force between unlike magnets to drive the two ends of the medicine preparation bottle to swing up and down, realizing multi-angle swinging mixing of medicine. The structure is simple and easy to use. VI. By setting up a partition plate, this invention can not only effectively isolate the interference between adjacent magnets and maintain the stability of the magnetic poles, but also provide a buffer for the impact of magnetic pole switching on the medicine preparation bottle, balance the overall device operation stability and hybrid power efficiency, avoid the movable magnet at the end of the medicine preparation bottle from swinging abruptly due to magnetic changes when the fixed magnet switches, improve the overall device operation stability, and reduce the risk of medicine leakage during the movement of the medicine preparation bottle. VII. The present invention, through the combined design of the bottle body and end cap, facilitates disassembly and installation. After disassembly, the inner wall of the bottle, guide rod and stirring wheel and other components can be thoroughly cleaned and disinfected, with no dead corners to clean, and it is not easy to leave any drug residue, thus eliminating drug residue and cross-contamination. Attached Figure Description
[0017] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.
[0018] Figure 1 This is a schematic diagram of a drug mixing and preparation device provided in an embodiment of the present invention; Figure 2 for Figure 1 A front view of the device shown; Figure 3 for Figure 2 Enlarged view of point A in the middle; Figure 4 for Figure 2 A cross-sectional view of the device shown; Figure 5 This is a schematic diagram showing the connection between the base and the dual-hybrid modulation frame; Figure 6 This is a schematic diagram of the dual-hybrid modulation frame; Figure 7 This is a schematic diagram of the rotating frame. Figure 8 This is a schematic diagram of the swing frame structure; Figure 9 This is a structural schematic diagram of the partition panel; Figure 10 This is a schematic diagram of the base structure; Figure 11 for Figure 11 Top view of the device shown; Figure 12 This is a schematic diagram of the structure of a medicine preparation bottle; Figure 13 for Figure 12 An exploded view of the device shown. Figure 14 for Figure 1 The diagram shows the usage status of the device. Figure 15 for Figure 14 Front view of the device shown.
[0019] Among them, 1. Medicine preparation bottle; 11. Bottle body; 11a. Dosing port; 12. End cap; 13. Limiting cylinder; 2. Base; 3. Rotary mixing driver; 4. Dual mixing and preparation frame; 41. Rotating frame; 41a. Strip groove; 42. Swing frame; 42a. Swing frame body; 42b. Roller; 42c. Connecting rod; 5. Swing mixing drive assembly; 51. First magnet; 52. Second magnet; 53. Third magnet; 54. Fourth magnet; 55. Partition plate; 6. Stirring and mixing assembly; 61. Guide rod; 61a. Limiting block; 62. Stirring wheel. Detailed Implementation
[0020] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings.
[0021] In the description of this invention, it should be understood that the terms "length direction," "upper," "lower," "front," "rear," "left," "right," "top," "bottom," "inner," "outer," "axial," "radial," and "circumferential," etc., indicating orientation or positional relationships, are based on the orientation or positional relationships shown in the accompanying drawings and are only for the convenience of describing the invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of the invention. Furthermore, features limited to "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this invention, unless otherwise stated, "a plurality of" means two or more.
[0022] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.
[0023] The inventors discovered that current drug preparation devices mix the drugs by swinging the bottom of the bottle from side to side. As a result, the swing range of the bottom of the bottle is much smaller than that of the top, leading to an imbalance in the concentration of the drug solution inside the bottle and insufficient mixing uniformity. Consequently, medical staff need to extend the stirring time during actual use, resulting in low preparation efficiency.
[0024] Based on the above findings, this application provides a drug mixing and preparation device, which includes a drug preparation bottle 1, a base 2, and a multi-stage mixing and preparation mechanism. The application achieves better drug mixing results through the following design: 1. The entire medicine preparation bottle 1 is detachable for thorough cleaning and disinfection, preventing cross-infection; 2. The multi-stage mixing mechanism can mix various drugs in the drug preparation bottle from multiple dimensions, breaking the limitations of single stirring and improving the uniformity and efficiency of mixing.
[0025] Example 1 This embodiment provides a drug mixing and preparation device, such as... Figure 1-15 As shown, it includes a drug preparation bottle 1, a base 2, and a multi-mixing and preparation mechanism.
[0026] The base 2 is used to mount the multi-stage mixing modulation mechanism. Specifically, the base 2 includes a circular support plate and multiple support legs fixedly disposed on the bottom surface of the circular support plate. The upper surface of the circular support plate has four circumferentially arranged fan-shaped grooves for fixing and mounting the multi-stage mixing modulation mechanism. The base 2 is made of a non-magnetic material; for example, it is made of wood or plastic. It should be noted that this embodiment of the invention does not limit the fixing connection method between the circular support plate and the support legs; for example, the fixing connection method is an integral fixed connection or a bolted connection.
[0027] The medicine preparation bottle 1 includes a bottle body 11, two end caps 12 and two limiting cylinders 13; wherein the bottle body 11, the two end caps 12 and the two limiting cylinders 13 are made of medical plastic.
[0028] Specifically, the bottle body 11 is a cylindrical structure with vertically connected components. Two dosing ports 11a are fixedly provided on the side of the bottle body 11. Each dosing port 11a is connected to the interior of the bottle body 11, and a sealing cap is detachably connected to the end of each dosing port 11a. Two limiting cylinders 13 are also fixedly provided on the side of the bottle body 11. These two limiting cylinders 13 are not connected to the interior of the bottle body 11. The limiting cylinders 13 are used for fixed connection with the multi-mixing and modulation mechanism. It should be noted that the embodiments of the present invention do not limit the fixed connection method between the bottle body 11 and the dosing ports 11a and the limiting cylinders 13. Preferably, the fixed connection method is an integral fixed connection. Two end caps 12 are located at opposite ends of the bottle body 11, and each end cap 12 is detachably connected to the end of the bottle body 11 on the same side. In this embodiment of the invention, the detachable connection between the end caps 12 and the bottle body 11 is not limited; for example, the detachable connection is a threaded connection. During the drug mixing and preparation process, the multi-mixing and preparation mechanism can be shut off midway, and then the end caps 12 can be opened to add the drug.
[0029] The multi-mixing modulation mechanism includes a rotary mixing driver 3, a dual mixing modulation frame 4, and a swing mixing drive assembly 5; Specifically, the rotary mixing driver 3 is a rotary motor. The rotary mixing driver 3 is fixedly mounted on the bottom surface of the circular support plate in the base 2, and the output end of the rotary mixing driver 3 passes through the circular support plate and is located above the circular support plate. In this embodiment of the invention, the model of the rotary mixing driver 3 is not limited. For example, the model of the rotary mixing driver 3 is LR17. In this embodiment of the invention, the fixed connection method between the rotary mixing driver 3 and the circular support plate is not limited. For example, the fixed connection method is welding or snap-fit connection.
[0030] The dual-mixing modulation frame 4 includes a rotating frame 41 and a swing frame 42; wherein the rotating frame 41 and the swing frame 42 are made of materials with high elastic modulus, for example, the elastic material is PPS engineering plastic or ASA engineering plastic.
[0031] The rotating frame 41 is fixedly connected to the output end of the rotating mixing driver 3; specifically, the rotating frame 41 has a Y-shaped structure; wherein, the embodiment of the present invention does not limit the fixed connection method between the rotating frame 41 and the rotating mixing driver 3, for example, the fixed connection method is a snap connection or a screw connection.
[0032] The swing frame 42 includes a swing frame body 42a, two rollers 42b, and two connecting rods 42c. Specifically, the swing frame body 42a has a C-shaped structure, forming an opening for engaging with the medicine preparation bottle 1. The two connecting rods 42c are fixedly disposed at both ends of the swing frame body 42a, and the end of each connecting rod 42c away from the swing frame body 42a is rotatably connected to the rotating frame 41. The two ends of the swing frame 42 are provided with grooves for rotatably connecting with the corresponding rollers 42b. Two rollers 42b are respectively located in corresponding grooves on the swing frame 42; specifically, each roller 42b is a circular cylindrical structure, and a rotating rod is fixedly provided at both ends of the roller 42b. Each rotating rod is rotatably connected to the inner wall of the groove of the swing frame 42. Correspondingly, a groove is provided on the inner wall of the groove of the swing frame 42 for rotatably connecting with the rotating rod of the roller 42b.
[0033] When in use, medical staff hold both ends of the medicine preparation bottle 1 and squeeze the medicine preparation bottle 1 into the opening of the swing frame body 42a. During this process, the two rollers 42b abut against the surface of the medicine preparation bottle 1, and under the squeezing force of the medicine preparation bottle 1, the swing frame body 42a deforms and the two ends of the swing frame body 42a separate, thereby opening the opening of the swing frame body 42a. During this process, the two rollers 42b roll along the surface of the medicine preparation bottle 1, thereby facilitating the quick entry of the medicine preparation bottle 1 into the opening of the swing frame body 42a, realizing the engagement between the medicine preparation bottle 1 and the swing frame 42. When removing the medicine preparation bottle 1, medical staff take the medicine preparation bottle 1 out between the two rollers 42b. During this process, the two rollers 42b continue to roll along the surface of the medicine preparation bottle 1, reducing the friction between the medicine preparation bottle 1 and the end of the swing frame body 42a, thereby realizing the quick installation or removal of the medicine preparation bottle 1.
[0034] The swing hybrid drive assembly 5 includes four fixed magnets and two movable magnets, both of which are permanent magnets. The four fixed magnets are fixedly installed in the fan-shaped grooves on the circular support plate in the base 2, and a partition plate 55 is fixedly installed between every two adjacent magnets. The two movable magnets are respectively fixedly installed in the corresponding limiting cylinders 13. Specifically, the four fixed magnets include two first magnets 51 and two second magnets 52; the first magnets 51 and the second magnets 52 are magnetically repulsive. Among them, the two first magnets 51 are symmetrically arranged with the dual mixing modulation frame 4 as the center, and each first magnet 51 is fixedly arranged in the corresponding fan-shaped groove; Two second magnets 52 are symmetrically arranged around the dual mixing modulation frame 4. Each second magnet 52 is fixedly arranged in the corresponding fan-shaped groove, and each second magnet 52 is perpendicular to the adjacent first magnet 51. The partition plate 55 has a T-shaped structure, and each partition plate 55 is fixedly installed between the first magnet 51 and the second magnet 52. The partition plate 55 is made of non-magnetic material, which can effectively isolate the interference between adjacent magnets, maintain the stability of magnetic poles, and buffer the impact of magnetic pole switching, thus balancing the operating stability of the device and the hybrid power efficiency.
[0035] The two movable magnets are the third magnet 53 and the fourth magnet 54. Specifically, the third magnet 53 and the fourth magnet 54 are both cylindrical structures, and the magnetism of the third magnet 53 and the fourth magnet 54 is opposite. The third magnet 53 has the same magnetism as the second magnet 52, and the fourth magnet 54 has the same magnetism as the first magnet 51.
[0036] It should be noted that the embodiments of the present invention do not limit the fixing connection method between the fixed magnet and the partition plate 55 and the base 2, or the fixing connection method between the movable magnet and the limiting cylinder 13. For example, the fixing connection method is adhesive or snap-fit connection.
[0037] In practical applications, the rotational speed of the medicine preparation bottle 1 can be adjusted by setting the rotational speed of the output shaft in the rotary mixing driver 3, and the magnitude of the magnetic attraction between the fixed magnet and the movable magnet can be limited by selecting permanent magnets with different magnetic attraction forces, thereby adjusting the up-and-down swing amplitude of the medicine preparation bottle 1 and controlling the drug mixing effect of the multi-mixing and modulation mechanism.
[0038] The present invention also provides a working principle of a drug mixing and preparation device as follows: medical staff start the rotary mixing driver 3; The mixing driver 3 drives the medicine preparation bottle 1 to rotate through the dual mixing and modulation frame 4; at the same time, under the magnetic attraction of the third magnet 53 to the first magnet 51 and the second magnet 52 respectively, and the magnetic attraction of the fourth magnet 54 to the first magnet 51 and the second magnet 52 respectively, the medicine preparation bottle 1 rotates while the two ends of the medicine preparation bottle 1 swing up and down, so as to realize the simultaneous rotational mixing and swing mixing of various medicines in the medicine preparation bottle 1. Specifically, the rotary mixing driver 3 drives the rotary frame 41 to rotate, and the rotary frame 41 drives the medicine preparation bottle 1 to rotate via the swing frame 42; When the end of the medicine preparation bottle 1 with the third magnet 53 rotates to be above one of the first magnets 51, the end of the medicine preparation bottle 1 with the fourth magnet 54 is above the other first magnet 51. At this time, the third magnet 53 and the first magnet 51 are magnetically connected, causing the end of the medicine preparation bottle 1 with the third magnet 53 to flip downwards. The fourth magnet 54 and the first magnet 51 generate a repulsive force, causing the end of the medicine preparation bottle 1 with the fourth magnet 54 to tilt upwards. During this process, the swing frame 42 swings synchronously with the medicine preparation bottle 1, and all the medicine inside the medicine preparation bottle 1 gathers at the end of the medicine preparation bottle 1 with the third magnet 53 under its own gravity. This achieves the rotational mixing of the medicine in the medicine preparation bottle 1 while simultaneously performing the first swing mixing of the medicine in the medicine preparation bottle 1. As the medicine preparation bottle 1 continues to rotate under the drive of the rotary mixing driver 3, when the end of the medicine preparation bottle 1 with the third magnet 53 leaves the top of the first magnet 51 and rotates to the top of the partition plate 55, the end of the medicine preparation bottle 1 with the fourth magnet 54 is located above another partition plate 55. During the process of the third magnet 53 and the fourth magnet 54 moving from the top of the fixed magnet to the top of the corresponding partition plate 55, the magnetic attraction or repulsion force they are subjected to gradually decreases, thereby causing the end of the medicine preparation bottle 1 with the third magnet 53 to flip upward. At this time, the medicine preparation bottle 1 gradually switches from the tilted state to the horizontal state. When the end of the medicine preparation bottle 1 equipped with the third magnet 53 rotates away from the partition plate 55 and is above the second magnet 52, the end of the medicine preparation bottle 1 equipped with the fourth magnet 54 is above the other second magnet 52. At this time, a repulsive force is generated between the third magnet 53 and the second magnet 52, causing the end of the medicine preparation bottle 1 equipped with the third magnet 53 to tilt upwards. The fourth magnet 54 is magnetically connected to the second magnet 52, causing the end of the medicine preparation bottle 1 equipped with the fourth magnet 54 to flip downwards. During this process, the swing frame 42 swings synchronously with the medicine preparation bottle 1, and all the medicine inside the medicine preparation bottle 1 gathers at the end of the medicine preparation bottle 1 equipped with the fourth magnet 54 under its own gravity. This achieves a dual mixing mechanism of rotating mixing and up-and-down swing mixing of the medicine in the medicine preparation bottle 1, thereby improving the mixing uniformity and efficiency.
[0039] Example 2 Based on Example 1, but unlike Example 1, in order to further improve the mixing uniformity and efficiency of the agent, the multi-mixing modulation mechanism provided in this embodiment of the invention also includes a stirring and mixing component 6.
[0040] The mixing assembly 6 includes a guide rod 61 and a stirring wheel 62; Specifically, the guide rod 61 is a straight rod structure, wherein the guide rod 61 is located inside the bottle body 11 and is fixedly connected to one of the end caps 12, and the other end of the guide rod 61 is in contact with the other end cap 12; the stirring wheel 62 is a cylindrical structure, and spiral stirring blades are fixedly arranged on the outer surface of the stirring wheel 62. It should be noted that the number of stirring wheels 62 is not limited in this embodiment of the invention. For example, this embodiment of the invention uses two stirring wheels 62 as an example.
[0041] In practical applications, a limiting block 61a is fixedly installed at the middle position of the guide rod 61. The limiting block 61a is located between the two stirring wheels 62. In this way, when the two ends of the bottle 11 swing up and down, the stirring wheel 62 can quickly slide to the same side under its own gravity. When the stirring wheel 62 slides under its own gravity, the spiral stirring blades on the side of the stirring wheel 62 rotate under the impact of the water flow to stir the medicine. This realizes a triple medicine mixing mechanism of rotational gentleness, oscillating mixing and stirring, which further improves the uniformity and efficiency of medicine mixing.
[0042] It should be noted that the present invention does not limit the fixed connection method between the fixing rod 61 and the end cap 12. For example, the fixed connection method is an integral fixed connection.
[0043] Example 3 Based on Embodiment 1, unlike Embodiments 1 and 2, the upper surface corner of the isolation plate 55 provided in this embodiment of the invention is chamfered.
[0044] In actual use, the chamfers of each isolation plate 55 first contact the medicine preparation bottle 1, and the end of the medicine preparation bottle 1 gradually rises along the chamfered slope of the isolation plate 55. That is, when the rotation direction of the medicine preparation bottle 1 is clockwise, the chamfers of each isolation plate 55 are located on the right side of the corresponding partition plate 55, and when the rotation direction of the medicine preparation bottle 1 is counterclockwise, the chamfers of each isolation plate 55 are located on the left side of the corresponding partition plate 55. The embodiment of the present invention is illustrated by taking the rotation direction of the medicine preparation bottle 1 as counterclockwise and the chamfers of each isolation plate 55 as being located on the left side of the corresponding partition plate 55.
[0045] In actual use, after the first magnet 51 and the third magnet 53 are magnetically connected, the third magnet 53 rotates with the medicine preparation bottle 1 to the chamfer of the adjacent isolation plate 55, and gradually moves upward along the chamfered slope of the isolation plate 55, so that the first magnet 51 and the third magnet 53 are separated; after the fourth magnet 54 is magnetically connected with the second magnet 52, the movement principle of the fourth magnet 54 is the same as that of the third magnet 53, which will not be described again here.
[0046] In this way, the chamfer at the upper surface end of the isolation plate 55 can separate the two magnetically connected magnets, thereby gradually reducing the magnetic attraction force on the end of the medicine preparation bottle 1. This effectively isolates the interference between adjacent magnets and maintains the stability of the magnetic poles, while also providing a buffer against the magnetic pole switching impact on the medicine preparation bottle. This balances the overall operating stability of the device with the hybrid power efficiency, prevents the medicine preparation bottle from swinging abruptly, greatly improves the operating stability, and reduces the risk of drug leakage in the medicine preparation bottle.
[0047] Example 4 Based on Embodiment 1, unlike Embodiments 1 to 3, the rotating frame 41 and the swing frame 42 provided in this embodiment of the invention are detachably connected.
[0048] Specifically, two strip-shaped grooves 41a are provided on the two sides of the rotating frame 41. These two strip-shaped grooves 41a are used for detachable connection with the swing frame 42. Among them, two symmetrically arranged arc-shaped grooves are provided on the inner walls of the two sides of the strip-shaped grooves 41a. These two arc-shaped grooves are used for rotatable connection with the corresponding connecting rods 42c.
[0049] In actual use, the rotating frame 41 and the swing frame 42 can be separated to clean and disinfect the entire device, so that the use of the entire device meets the clinical aseptic operation standards.
[0050] Application examples: Taking the preparation of cefuroxime sodium for injection as an example, the use of the drug mixing and preparation device provided in this embodiment of the invention includes the following steps: S1: Prepare the following medicines: 0.75g cefuroxime sodium powder for injection, 100ml 0.9% sodium chloride injection infusion bag, sterile syringe (20ml), alcohol swabs and the medicine preparation device provided by this invention; S2: Solvent extraction and dissolution; specifically, this step includes the following steps: S201: Disinfect the infusion bag's medication dispensing port and the powder injection bottle stopper with an alcohol swab, and allow them to dry; S202: Use a sterile syringe to draw 20ml of 0.9% sodium chloride injection solution and inject it into a bottle of cefuroxime sodium powder for injection; S203: Shake gently to mix; S3: Transfer of drug solution; Specifically, a sterile syringe is used to extract all 20ml of the dissolved drug solution from the cefuroxime sodium powder injection vial and transfer it to the bed pharmaceutical preparation device; S4: Secondary mixing of the drug solution; specifically, this step includes the following steps: S401: Start rotary mixing driver 3; S402: The rotary mixing driver 3 drives the rotating frame 41 to rotate, and the rotating frame 41 drives the medicine preparation bottle 1 to rotate through the swing frame 42; at the same time, under the magnetic attraction of the third magnet 53 to the first magnet 51 and the second magnet 52 respectively, and the magnetic attraction of the fourth magnet 54 to the first magnet 51 and the second magnet 52 respectively, the medicine preparation bottle 1 rotates while the two ends of the medicine preparation bottle 1 swing back and forth, so as to realize the simultaneous rotary mixing and swing mixing of various medicines in the medicine preparation bottle 1, thereby improving the uniformity and efficiency of medicine mixing. When the bottle body 11 swings up and down at both ends, the stirring wheel 62 can quickly slide to the same side under its own gravity to stir the medicine, thereby realizing a triple medicine mixing mechanism of rotational mixing, swinging mixing and stirring, which further improves the uniformity and efficiency of medicine mixing. At this time, the secondary mixing of the medicine is completed. S5: Using a sterile syringe, transfer all the mixed medication solution into a 100ml 0.9% sodium chloride injection infusion bag, and then gently invert the infusion bag three times to ensure that the medication solution is mixed evenly, with a final concentration of approximately 7.5 mg / ml. S6: Quality inspection; ensure the liquid is free of turbidity, sediment, crystals, discoloration, and bubbles; S7: Administer intravenous infusion.
[0051] The contents not described in detail in this specification are existing technologies known to those skilled in the art.
Claims
1. A pharmaceutical mixing and preparation device, comprising a base (2), characterized in that, Also includes: The medicine preparation bottle (1) is located above the base (2); The multi-mixing and mixing mechanism is set on the base (2) and is detachably connected to the drug mixing bottle (1) for simultaneously rotating and oscillating mixing of various drugs in the drug mixing bottle (1).
2. The pharmaceutical mixing and preparation device according to claim 1, characterized in that, Multiple hybrid modulation mechanisms include: A rotary mixing driver (3) is vertically mounted on a base (2), and the output end of the rotary mixing driver (3) extends out of the base (2) and is located above the base (2); A dual mixing and modulation rack (4) is set on the output end of the rotary mixing driver (3) and is detachably connected to the drug mixing bottle (1); The oscillating mixing drive assembly (5) is connected to the base (2) and the drug preparation bottle (1) respectively.
3. The pharmaceutical mixing and preparation device according to claim 2, characterized in that, The dual-hybrid modulation frame (4) includes: The rotating frame (41) has a Y-shaped structure and is connected to the output end of the rotary mixing driver (3); The swing frame (42) is mounted on the rotating frame (41) and is engaged with the medicine preparation bottle (1).
4. The pharmaceutical mixing and preparation device according to claim 3, characterized in that, The swing frame (42) includes: The swing frame body (42a) is connected to the rotating frame (41) at both ends by connecting rods (42c), and the middle position of the swing frame body (42a) is engaged with the medicine preparation bottle (1); Two rollers (42b) are respectively located at both ends of the swing frame body (42a) and are in contact with the medicine preparation bottle (1).
5. A pharmaceutical mixing and preparation device according to claim 2, characterized in that, The oscillating hybrid drive assembly (5) includes: Two first magnets (51) are symmetrically arranged on the base (2) with the dual hybrid modulation frame (4) as the center; Two second magnets (52) are symmetrically arranged on the base (2) and perpendicular to the two first fixed magnets (51); the second magnets (52) and the first magnets (51) are magnetically repulsive; The third magnet (53) is located at one end of the medicine preparation bottle (1) and is magnetically connected to the first magnet (51); The fourth magnet (54) is located at the other end of the medicine preparation bottle (1) and is magnetically connected to the second magnet (52).
6. The pharmaceutical mixing and preparation device according to claim 5, characterized in that, Each first magnet (51) is provided with a partition plate (55) between it and each of the adjacent second magnets (52).
7. A pharmaceutical mixing and preparation apparatus according to claim 6, characterized in that, Each partition (55) has a T-shaped structure, and one end of the upper surface of the partition (55) is chamfered.
8. The pharmaceutical mixing and preparation apparatus according to claim 1, characterized in that, The medicine preparation bottle (1) includes: The bottle body (11) has a cylindrical structure and is detachably connected to the multi-mixing and modulation mechanism; Two end caps (12) are respectively located at both ends of the bottle body (11) and are detachably connected to the bottle body; Two limiting cylinders (13) are provided on the side of the bottle body (11), and each limiting cylinder (13) is used to connect to the multi-mixing modulation mechanism.
9. A pharmaceutical mixing and preparation device according to claim 8, characterized in that, The multi-mixing modulation mechanism also includes a stirring and mixing component (6); the stirring and mixing component (6) includes: The guide rod (61) is located inside the bottle body (11) and is connected to any end cap (12); The stirring wheel (62) is slidably mounted on the guide rod (61).