Concentration and purification device for vaccine production

Abstract

The invention belongs to the technical field of vaccine production, and provides a concentration and purification device for vaccine production, which comprises an upper tank body and a lower tank body, the upper tank body is detachably connected with the lower tank body, the upper tank body is communicated with a feed pipe, a stirring assembly for stirring materials is arranged in the upper tank body, and the lower tank body is communicated with the feed pipe. A mounting ring with an annular structure is fixedly mounted in the lower tank body, a filter membrane is arranged on the mounting ring, and a fixing assembly for pressing the filter membrane is arranged on the mounting ring. The invention aims to solve the technical problems of waste of plenty of time and reduction of purification efficiency caused by frequent disassembly and cleaning of a filter membrane in the prior art. Compared with the prior art, the invention has the following beneficial effects: automatic cleaning and collection of filter residues on the filter membrane are realized, the time consumption for cleaning the filter membrane is reduced while the manual workload is reduced, large pressure can be formed after a small amount of air enters the upper tank body, the air inlet amount is reduced, and the pressurization efficiency is improved; the filtering speed and the filtering effect of the inactivated cells are improved.

Description

Technical Field

[0001] This invention belongs to the field of vaccine production technology, and in particular relates to a concentration and purification device for vaccine production. Background Technology

[0002] In the field of animal biomedicine, inactivated virus vaccines typically use the old roller bottle technology for propagation and cell inoculation. After inoculation, the virus is released naturally and then inactivated. The old production process results in poor vaccine quality uniformity, increased risk of contamination, low virus titer, inability to remove impurities and cell debris, and strong side effects.

[0003] Existing purification devices suffer from poor cell disruption and concentration effects, as well as incomplete virus filtration. To address these technical issues, the applicant has identified some existing technologies, such as Chinese Patent Publication No. CN210409034U. This patent accelerates material filtration and purification by pressurizing the device with air. However, after purification, the device needs to be opened, and the filter membrane needs to be cleaned and replaced manually. This process significantly increases the time spent cleaning the filter membrane, increases manual workload, and reduces purification efficiency. Summary of the Invention

[0004] The purpose of this invention is to provide a concentration and purification device for vaccine production, which aims to solve the technical problem in the prior art that the need for frequent disassembly and cleaning of filter membranes leads to a waste of a lot of time and a reduction in purification efficiency.

[0005] The present invention is implemented as follows: a concentration and purification device for vaccine production includes an upper tank and a lower tank, which are detachably connected. A feed pipe is connected to the upper tank. A stirring component for stirring materials is provided inside the upper tank. An annular mounting ring is fixedly installed inside the lower tank. A filter membrane is provided on the mounting ring. A fixing component for pressing the filter membrane is provided on the mounting ring. A pressurizing component for applying pressure to the materials is provided on the upper tank.

[0006] A further technical solution: A guide hopper for separating materials inside the upper tank is fixedly installed inside the upper tank. The guide hopper has a funnel-shaped structure.

[0007] Further technical solution: The stirring assembly includes a cover plate, which is detachably connected to the upper tank. A magnetized stirring device body extending into the upper tank is fixedly installed on the cover plate.

[0008] A further technical solution: The fixing component includes a retaining ring, which is fixedly installed on the mounting ring and is coaxially arranged with the mounting ring. The filter membrane is located inside the retaining ring, and a pressure plate with an annular structure for pressing the filter membrane is slidably installed inside the retaining ring. The pressure plate has a triangular cross-section.

[0009] A further technical solution: The retaining ring has multiple sets of slots, and a screw is threadedly connected to the slot. A connecting block that is slidably installed in the slot is threadedly connected to the screw. The connecting block is fixedly connected to the pressure plate.

[0010] A further technical solution: The semi-open area formed by the retaining ring, the lower tank, and the mounting ring is a collection chamber, and the upper tank is connected to an inlet pipe that extends into the collection chamber.

[0011] A further technical solution: A ring-shaped sealing baffle is slidably installed inside the upper tank. The sealing baffle slides in contact with the inner wall of the upper tank. The sealing baffle works in conjunction with the retaining ring. Multiple sets of telescopic components for moving the sealing baffle are fixedly installed inside the upper tank.

[0012] Further technical solution: The pressurization component includes an air pump, which is connected to a connecting chamber, and the connecting chamber is connected to a first pipe and a second pipe extending into the upper tank.

[0013] A further technical solution: The second pipe is located inside the upper tank, with one end pointing towards the filter membrane and a rotating box rotatably mounted on its end. The rotating box is connected to multiple sets of air outlet pipes arranged in a circular array around the rotating box, and the extension line of the air outlet pipes deviates from the rotation axis of the rotating box.

[0014] Compared with the prior art, the beneficial effects of the present invention are as follows: 1. It enables automatic cleaning and collection of filter residue on the filter membrane, eliminating the need for frequent disassembly of the device for manual cleaning. This reduces the workload and time spent cleaning the filter membrane, thereby improving purification efficiency.

[0015] 2. The sealing baffle at the top prevents air from entering the collection chamber, reducing the pressurization space. This allows a small amount of air to enter the upper tank and create greater pressure, reducing the air intake and improving pressurization efficiency. Simultaneously, the increased pressure accelerates the penetration of inactivated cells through the filter membrane, enhancing the filtration speed and effectiveness of cell inactivation. 3. The upper sealing baffle restricts the residue, ensuring that after the residue passes the baffle ring, it can only enter the collection chamber downwards, preventing the residue from returning to the filter membrane and improving the residue removal effect. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the overall structure of the present invention.

[0017] Figure 2 This is a cross-sectional structural diagram of the present invention.

[0018] Figure 3 This is a cross-sectional view of the sealing baffle in this invention.

[0019] Figure 4This is a schematic diagram of the lower tank in this invention.

[0020] Figure 5 for Figure 2 A magnified view of region A1 in the middle.

[0021] Figure 6 for Figure 2 A magnified view of region A2 in the middle.

[0022] In the attached diagram: 1. Upper tank; 2. Lower tank; 3. Feed pipe; 4. Cover plate; 5. Main body of magnetized stirring equipment; 6. Guide hopper; 7. Telescopic component; 8. Sealing baffle; 9. Mounting ring; 10. Retaining ring; 11. Slot; 12. Screw; 13. Pressure plate; 14. Connecting block; 15. Collection chamber; 16. Filter membrane; 17. Air pump; 18. Connecting chamber; 19. First pipe; 20. Second pipe; 21. Rotating box; 22. Air outlet pipe; 23. Water inlet pipe; 24. Stirring assembly; 25. Fixing assembly; 26. Pressurizing assembly. Detailed Implementation

[0023] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the invention.

[0024] The specific implementation of the present invention will be described in detail below with reference to specific embodiments.

[0025] like Figures 1-6 As shown, this invention provides a concentration and purification device for vaccine production, comprising an upper tank 1 and a lower tank 2, which are detachably connected. An inlet pipe 3 is connected to the upper tank 1. A stirring assembly 24 for stirring materials is installed inside the upper tank 1. A guide hopper 6 for separating materials within the upper tank 1 is fixedly installed inside the upper tank 1; the guide hopper 6 has a funnel-shaped structure. An annular mounting ring 9 is fixedly installed inside the lower tank 2. A filter membrane 16 is mounted on the mounting ring 9, and a fixing assembly 25 for pressing the filter membrane 16 is mounted on the mounting ring 9. A pressurizing assembly 26 for applying pressure to the materials is installed on the upper tank 1.

[0026] In practical application, the filter membrane 16 is laid flat on the mounting ring 9 and then fixed by the fixing component 25. After fixing, the upper tank 1 and the lower tank 2 are connected, the valve on the feed hopper 6 is closed, and the purified raw material is then transported to the upper tank 1 through the feed pipe 3. The material remains on the feed hopper 6, where the stirring component 24 can be used to stir the material. Under the action of stirring, the cells are broken and mixed evenly with other materials. After stirring, the valve on the feed hopper 6 is opened, and the material falls onto the filter membrane 16 below. After all the material has fallen, the valve on the feed hopper 6 is closed again. At this time, the pressurizing component 26 pressurizes the area between the filter membrane 16 and the feed hopper 6. Air is introduced into the filter membrane 16, thereby increasing the pressure in the area between the filter membrane 16 and the feed hopper 6. This increased pressure increases the pressure of the air on the material below, accelerating the speed at which the material passes through the filter membrane 16 and thus speeding up the filtration and purification process. The material passing through the filter membrane 16 accumulates at the bottom of the lower tank 2 and is subsequently discharged through the discharge pipe. When cleaning is required, the pressurizing component 26 blows air onto the surface of the filter membrane 16, thereby blowing away impurities on the surface of the filter membrane 16 under the action of air, achieving self-cleaning of impurities. When the filter membrane 16 needs to be replaced after long-term use, the lower tank 2 is separated from the upper tank 1, and then the fixing component 25 is released from fixing the filter membrane 16 to replace it with a new filter membrane 16.

[0027] like Figures 1-3 As shown, this invention provides a concentration and purification device for vaccine production. The stirring assembly 24 includes a cover plate 4, which is detachably connected to the upper tank 1. A magnetized stirring device body 5, which extends into the upper tank 1, is fixedly installed on the cover plate 4. In practical application, the cover plate 4 is installed on the upper tank 1 and then fixed with fixing screws. At this time, the main body 5 of the magnetized stirring device is located inside the upper tank 1, and the material in the upper tank 1 can be stirred by the main body 5 of the magnetized stirring device.

[0028] like Figures 1-5 As shown, this invention provides a concentration and purification device for vaccine production. The fixing component 25 includes a retaining ring 10, which is fixedly installed on the mounting ring 9 and is coaxially arranged with the mounting ring 9. The filter membrane 16 is located inside the retaining ring 10, and a ring-shaped pressure plate 13 for pressing the filter membrane 16 is slidably installed inside the retaining ring 10. The pressure plate 13 has a triangular cross-section.

[0029] Specifically, the retaining ring 10 has multiple sets of slots 11, and a screw 12 is threadedly connected to the slot 11. A connecting block 14 is threadedly connected to the screw 12 and slidably installed in the slot 11. The connecting block 14 is fixedly connected to the pressure plate 13.

[0030] Specifically, the semi-open area enclosed by the retaining ring 10, the lower tank 2, and the mounting ring 9 is the collection chamber 15, and the upper tank 1 is connected to the water inlet pipe 23 that extends into the collection chamber 15.

[0031] Specifically, an annular sealing baffle 8 is slidably installed inside the upper tank 1. The sealing baffle 8 slides in contact with the inner wall of the upper tank 1. The sealing baffle 8 works in conjunction with the retaining ring 10. Multiple sets of telescopic components 7 are fixedly installed inside the upper tank 1 to drive the sealing baffle 8 to move.

[0032] In practical application, the filter membrane 16 is laid flat on the mounting ring 9. At this time, the filter membrane 16 is located inside the retaining ring 10. The pressure plate 13 is slidably installed inside the retaining ring 10 through the connecting block 14. At this time, the pressure plate 13 presses the filter membrane 16 onto the mounting ring 9. Then, the screw 12 passes through the connecting block 14 and is connected to the retaining ring 10. The screw 12 applies pressure to the pressure plate 13, so that the pressure plate 13 can press the filter membrane 16 tightly onto the mounting ring 9, increasing the stability of the filter membrane 16 installation. When pressurized filters the inactivated cells on the filter membrane 16, the telescopic component 7 moves the sealing baffle 8 downward so that the sealing baffle 8 and the retaining ring 10 make a sealing contact, thereby preventing air from entering the collection chamber 15, reducing the pressurization space, and thus forming a larger pressure after a small amount of air enters the upper tank 1, reducing the air intake and improving the pressurization efficiency. At the same time, the increased pressure can accelerate the inactivated cells through the filter membrane 16, improving the filtration speed and effect of inactivated cells. When cleaning the residue on the filter membrane 16, the sealing baffle 8 moves upward away from the baffle ring 10. Under the blowing of air, the residue on the surface of the filter membrane 16 moves outward. Since the inner side of the pressure plate 13 is a sloping structure, the residue will rise along the pressure plate 13 under the action of wind. The sealing baffle 8 above restricts the residue, so that after the residue crosses the baffle ring 10, it can only enter the collection chamber 15 downward, preventing the residue from returning to the filter membrane 16, improving the removal effect of the residue, and ensuring the cleanliness of the filter membrane 16. Subsequently, clean water is injected into the collection chamber 15 through the water inlet pipe 23. After entering the collection chamber 15, the clean water rinses and carries the residue out through the drain pipe, thereby realizing the automatic cleaning and collection of filter residue. There is no need for frequent disassembly of the device for manual cleaning, which reduces the amount of manual labor and the time consumed in cleaning the filter membrane 16, thereby improving the purification efficiency.

[0033] In one embodiment of the present invention, the telescopic component 7 is an electric telescopic rod, but it can also be other components such as a hydraulic cylinder that can actively change length. The electric telescopic rod drives the sealing baffle 8 to move up and down to adjust the position of the sealing baffle 8.

[0034] like Figure 1 , Figure 2 , Figure 6As shown, this invention provides a concentration and purification device for vaccine production. The pressurization component 26 includes an air pump 17, which is connected to a communication chamber 18. The communication chamber 18 is connected to a first pipe 19 and a second pipe 20 that extend into the upper tank 1.

[0035] Specifically, the second pipe 20 is located inside the upper tank 1, with one end pointing to the filter membrane 16 and a rotating box 21 rotatably mounted on its end. The rotating box 21 is connected to multiple sets of air outlet pipes 22 arranged in a circular array around the rotating box 21. The extension line of the air outlet pipe 22 deviates from the rotation axis of the rotating box 21.

[0036] In practical application, during pressurized filtration, the valve on the first pipe 19 is opened and the valve on the second pipe 20 is closed. At this time, the air pump 17 delivers high-pressure air into the connecting chamber 18. Then, the high-pressure air enters the area between the guide hopper 6 and the filter membrane 16 through the first pipe 19. At this time, the pressure in the area between the guide hopper 6 and the filter membrane 16 increases, thereby accelerating the inactivated cells to pass through the filter membrane 16 under the action of air pressure, and improving the filtration speed and effect of inactivated cells. When cleaning the filter membrane 16, the valves on the first pipe 19 and the second pipe 20 are switched. At this time, air enters the rotating box 21 through the second pipe 20, and then the air is sprayed out through the air outlet pipe 22. Since the extension line of the air outlet pipe 22 is deviated from the rotation axis of the rotating box 21, the reaction force when the air is sprayed out can push the rotating box 21 to rotate, so that the air can be evenly blown from the middle position of the filter membrane 16 to the surrounding area. The impurities remaining on the surface of the filter membrane 16 are blown away by the fast-flowing air, thereby achieving the self-cleaning of the filter membrane 16.

[0037] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

[0038] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A concentration and purification apparatus for vaccine production, comprising an upper tank (1) and a lower tank (2), wherein the upper tank (1) and the lower tank (2) are detachably connected, and a feed pipe (3) is connected to the upper tank (1), characterized in that, The upper tank (1) is provided with a stirring assembly (24) for stirring materials. The lower tank (2) is fixedly installed with an annular structure mounting ring (9). A filter membrane (16) is provided on the mounting ring (9). A fixing assembly (25) for pressing the filter membrane (16) is provided on the mounting ring (9). A pressurizing assembly (26) for applying pressure to the materials is provided on the upper tank (1).

2. The concentration and purification apparatus for vaccine production according to claim 1, characterized in that, The upper tank (1) is fixedly installed with a guide hopper (6) for separating the materials inside the upper tank (1). The guide hopper (6) has a funnel-shaped structure.

3. The concentration and purification apparatus for vaccine production according to claim 1, characterized in that, The stirring assembly (24) includes a cover plate (4), which is detachably connected to the upper tank (1). A magnetized stirring device body (5) extending into the upper tank (1) is fixedly installed on the cover plate (4).

4. The concentration and purification apparatus for vaccine production according to claim 1, characterized in that, The fixing component (25) includes a retaining ring (10), which is fixedly installed on the mounting ring (9) and is coaxially arranged with the mounting ring (9). The filter membrane (16) is located inside the retaining ring (10), and a ring-shaped pressure plate (13) for pressing the filter membrane (16) is slidably installed inside the retaining ring (10). The pressure plate (13) has a triangular cross-section.

5. A concentration and purification apparatus for vaccine production according to claim 4, characterized in that, The retaining ring (10) has multiple sets of slots (11), and a screw (12) is threadedly connected to the slot (11). A connecting block (14) is threadedly connected to the screw (12) and is slidably installed in the slot (11). The connecting block (14) is fixedly connected to the pressure plate (13).

6. The concentration and purification apparatus for vaccine production according to claim 5, characterized in that, The semi-open area enclosed by the retaining ring (10), the lower tank (2), and the mounting ring (9) is the collection chamber (15), and the upper tank (1) is connected to the water inlet pipe (23) that extends into the collection chamber (15).

7. A concentration and purification apparatus for vaccine production according to claim 6, characterized in that, A ring-shaped sealing baffle (8) is slidably installed inside the upper tank (1). The sealing baffle (8) slides in contact with the inner wall of the upper tank (1). The sealing baffle (8) works in conjunction with the retaining ring (10). Multiple sets of telescopic components (7) for moving the sealing baffle (8) are fixedly installed inside the upper tank (1).

8. A concentration and purification apparatus for vaccine production according to claim 1, characterized in that, The pressurization assembly (26) includes an air pump (17), which is connected to a connecting chamber (18), and the connecting chamber (18) is connected to a first pipe (19) and a second pipe (20) extending into the upper tank (1).

9. A concentration and purification apparatus for vaccine production according to claim 8, characterized in that, The second pipe (20) is located inside the upper tank (1) with one end pointing to the filter membrane (16) and a rotating box (21) is rotatably installed at its end. Multiple sets of air outlet pipes (22) are connected to the rotating box (21) in a circular array around the rotating box (21). The extension line of the air outlet pipe (22) deviates from the rotation axis of the rotating box (21).

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