Synergistic acaricidal composition

Abstract

The invention belongs to the technical field of pesticides, and particularly relates to the technical field of pesticide compounding, in particular to a synergistic acaricidal composition. The synergistic acaricidal composition comprises an active compound (A), a compound shown in a formula Ia (formula Ia) and at least one active compound (B), and the active compound (B) is selected from the group consisting of chlorfenapyr, phoxim, dimethoate, pyridazinofos, carbosulfan, amitraz, lambda-cyhalothrin, lime sulfur, sulfur, chlorpyrifos, profenofos, lambda-cyhalothrin, triflumizone, Sulfiflumin, Spirobudifen, Mivorisaner, Modoplaner, Tigolaner, Umifoxolaner and Flupentifenox. The weight ratio of the active compound (A) to the active compound (B) is (1: 100)-(100: 1). The synergistic acaricidal composition can effectively improve the prevention and control effect on pest mites, has a remarkable synergistic effect compared with a single agent, and can effectively reduce the use amount, reduce the use cost and reduce the influence on the environment.

Description

Technical Field

[0001] This invention belongs to the field of pesticide technology, specifically to the field of pesticide compound technology, and in particular, to an acaricide composition with synergistic effects. Background Technology

[0002] Chinese invention patent CN110028431A discloses a trifluoroethyl sulfide (sulfoxide) substituted benzene compound and its acaricidal use, especially showing outstanding control effect on harmful mites. The general formula of the compound is: (Formula I) In Formula I above, R1 and R2 are each independently selected from hydrogen, halogen, cyano, C1-C4 alkyl or C1-C4 haloalkyl; n is selected from 0 or 1; R3, R4, R5, and R6 are each independently selected from hydrogen, halogen, cyano, nitro, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, or C1-C4 haloalkoxy.

[0003] In practical agricultural production, acaricides containing a single active ingredient, if used continuously for many years, can easily lead to varying degrees of resistance in mites. To address this issue, those skilled in the art typically combine two active ingredients. Through specific experiments, they screen for compositions and weight ratios with synergistic effects, which can effectively improve control efficacy, reduce pesticide dosage, lower application costs, and delay the development of mite resistance. However, the combination of two active ingredients may result in three different outcomes: antagonism, additive effect, or synergistic effect. Whether a synergistic effect will occur is unpredictable and requires specific experimental testing to determine.

[0004] Through specific experimental research, the applicant discovered that in Formula I above, when R1 is F, R2 is Me, R3 is H, R4 is H, R5 is H, R6 is H, and n is 1, that is, compound No. 2 disclosed in patent document CN110028431A (hereinafter referred to as compound 2#), it exhibits excellent acaricidal activity. Furthermore, when this compound is combined with other existing acaricidal compounds in a specific ratio, it shows a significant synergistic effect. The specific structural formula of this compound is shown in Formula Ia below: (Formula Ia).

[0005] In the prior art, there are no reports of compounds with the structural formula Ia being combined with other compounds. Summary of the Invention

[0006] The purpose of this invention is to provide an acaricidal composition with synergistic active ingredients to meet the agricultural demand for improved efficacy and delayed resistance development in the control of pests and mites. Furthermore, under the national policy of reducing pesticide use while increasing efficiency, it can replace highly toxic or environmentally unfriendly pesticides.

[0007] To achieve the above objectives, the technical solution adopted by the present invention is as follows: A synergistic acaricide composition comprising: an active compound (A), said active compound (A) being at least one compound of formula I: (Formula I) In Formula I above, R1 and R2 are each independently selected from hydrogen, halogen, cyano, C1-C4 alkyl or C1-C4 haloalkyl; n is selected from 0 or 1; R3, R4, R5, and R6 are each independently selected from hydrogen, halogen, cyano, nitro, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, or C1-C4 haloalkoxy.

[0008] And at least one active compound (B), said active compound B being selected from: Chlorfenapyr, phoxim, dimethoate, pyridaben, carbofuran, amitraz, lambda-cyhalothrin, lime sulfur, sulfur, chlorpyrifos, profenofos, lambda-cyhalothrin, trifluralin, Sulfiflumin, Spirobudifen, Mivorilaner, Modoflaver, Tigolaner, Umifoxolaner, Flupentiofenox.

[0009] Preferably, the active compound (A) in the synergistic acaricidal composition of the present invention is a compound of formula Ia: (Formula Ia).

[0010] More preferably, the weight ratio of the active compound (A) to the active compound (B) is 1:100 to 100:1.

[0011] More preferably, the weight ratio of the active compound (A) to the active compound (B) is 5:1 to 1:5.

[0012] The present invention also provides an acaricide, wherein the formulation comprises an acaricidal active ingredient and an adjuvant, wherein the acaricidal active ingredient is the above-mentioned synergistic acaricidal composition.

[0013] More preferably, the acaricide formulation is: suspension concentrate, microemulsion, water-dispersible granules, soluble concentrate, dispersible oil suspension, ultra-low volume liquid, dispersible liquid, soluble colloid, emulsifiable concentrate, water emulsion, microcapsule suspension, microcapsule suspension-water emulsion, microcapsule suspension-suspension, microcapsule suspension-suspension concentrate, suspension emulsion, oil, powder, soluble powder, soluble granules, or wettable powder.

[0014] More preferably, the acaricide comprises the active ingredient in a high-purity form (a solid active ingredient of a specific purity) mixed with at least one of the adjuvants commonly used in the pesticide processing field, including surfactants, antifreeze agents, defoamers, thickeners, preservatives, pH adjusters, and deionized water.

[0015] The surfactant used depends on the type of active ingredient to be formulated. Suitable surfactants are anionic, cationic, nonionic surfactants or mixtures of surfactants. They have good emulsifying, dispersing, wetting, spreading, penetrating and synergistic properties. They are commonly used or permitted ingredients in the field of pesticide formulation processing and are not particularly limited. The specific ingredients and dosages are determined by experiments according to the formulation requirements.

[0016] Examples of anionic surfactants described are water-soluble synthetic anionic and water-soluble soap-type anionic surfactants. Synthetic anionic surfactants specifically refer to fatty sulfonates, fatty sulfates, and alkylaryl sulfonates. Fatty sulfonates and fatty sulfates are typically present as alkali metal salts, alkaline earth metal salts, or (substituted or unsubstituted) triethanolamine salts. They are generally alkyl groups containing about 8-22 carbon atoms, and the alkyl group here should also be understood to include an alkyl moiety including an acyl group, such as sodium / calcium lignin sulfonate, dodecyl sulfate, or sodium dodecyl sulfate, and should also include sulfate or sulfonate salts of fatty alcohol / ethylene oxide adducts. Examples of alkylaryl sulfonates are sodium, calcium, (substituted or unsubstituted) triethanolamine salts of dibutylnaphthalenesulfonic acid or naphthalenesulfonic acid / formaldehyde condensates, and possibly phosphates, such as phosphate or sulfate salts of alkylaryl (4-14) ethylene oxide adducts; water-soluble soap-type anionic surfactants are typically alkali metal, alkaline earth metal, or ammonium salts of fatty acids having about 10-22 carbon atoms, such as sodium or potassium salts of oleic acid or stearic acid, and sodium or potassium salts of natural fatty acid mixtures obtained from natural oils, with particular emphasis on fatty acid methyl taurate.

[0017] The aforementioned cationic surfactants include amine salt cations and quaternary ammonium salt cations. Ammonium salt cations are typically formed by the neutralization of higher primary, secondary, and tertiary amines with acids. The hydrophobic moiety generally has 10-18 carbon atoms. Acids used to neutralize aliphatic amines include hydrochloric acid, formic acid, acetic acid, and sulfuric acid. Quaternary ammonium salt cations are generally quaternary ammonium salts with at least one alkyl group having 8 to 22 carbon atoms as a substituent, as well as lower alkyl, hydroxyalkyl, or benzyl groups as substituents.

[0018] The nonionic surfactants specifically refer to polyethylene glycol ether derivatives of aliphatic or cyclic aliphatic alcohols, saturated or unsaturated fatty acids, or alkylphenols. These aliphatic or cyclic aliphatic alcohol moieties contain 8-16 carbon atoms, or the alkyl moieties of alkylphenols contain 6-18 carbon atoms. The polyethylene glycol ether derivatives contain 3-30 glycol ether groups. Another class consists of adducts of polyethylene oxide with polypropylene glycol or alkyl polypropylene glycol, or ethylenediamine polypropylene glycol. Typically, these adducts contain approximately 1-10 carbon atoms in the alkyl moieties, 10-250 glycol ether units, and 10-100 propylene glycol ether units. Examples include castor oil polyethylene glycol ether, polyethylene oxide / polypropylene oxide, tributylphenoxy polyethylene glycol, and polyoxyethylene sorbitan trioleate.

[0019] The antifreeze agent is any antifreeze agent known in the field of pesticide formulations, and may be one or more of ethylene glycol, propylene glycol, glycerol, diethylene glycol, urea, and inorganic salts.

[0020] The defoamer is one or more of the following well-known defoamers in the field of pesticide formulation: silicone compounds, epoxidized soybean oil, emulsified silicone oil, and fatty alcohols.

[0021] The thickener is one or more of the following known thickeners in the field of pesticide formulation: xanthan gum, polyvinyl alcohol, sodium alginate, gum arabic, magnesium aluminum silicate, and silica.

[0022] The preservative is a variety of preservatives known in the field of pesticide formulations, and the preservative may be one or more of Kathon, sodium benzoate, benzoic acid, potassium sorbate, and formaldehyde.

[0023] The acid-base regulators mentioned are various acidic, alkaline, and buffer solutions known in the field of pesticide formulation. Specific examples of acids include hydrochloric acid, sulfuric acid, acetic acid, phosphoric acid, citric acid, tartaric acid, maleic acid, acidic amino acids, malic acid, potassium dihydrogen sulfate, and ammonium sulfate; specific examples of alkalines include sodium hydroxide, potassium hydroxide, ammonia solution, ethylenediamine, ethanolamine, dipotassium hydrogen phosphate, and basic amino acids; examples of buffer solutions include phosphate buffer solutions, borate buffer solutions, and boric acid buffer solutions.

[0024] The deionized water mentioned is industrially produced deionized water.

[0025] Typically, these compositions contain 0.1% to 95% of the active ingredient and 5% to 99.9% of at least one solid or liquid adjuvant.

[0026] More preferably, the total mass of the acaricidal active ingredient accounts for 1 to 60% of the total mass of the formulation, by mass percentage.

[0027] The present invention also provides the application of the above-mentioned synergistic acaricidal composition in the control of harmful mites. Preferably, the harmful mites include wheat long-legged spider, wheat round spider, cotton carmine spider mite, vegetable spider mite, hawthorn spider mite, citrus pterocaryon, citrus rust mite, apple spider mite, two-spotted spider mite, gall mite, flour mite, tea short-haired mite, alfalfa bryophyte mite, and citrus tumor mite. Beneficial effects

[0028] 1. The synergistic acaricide composition of the present invention, at a ratio of 100:1 to 1:100, has a synergistic coefficient much higher than 120 compared to a single agent, and the synergistic effect is significant; 2. It reduced the amount of pesticides used and lowered the cost of pesticide use; 3. Improved the control effect of pesticides on mites; 4. It delays the development of pesticide resistance in mites and extends the lifespan of the pesticide. Detailed Implementation

[0029] The following specific examples further illustrate the efficacy of compound 2# (hereinafter referred to as 2#) in controlling various mixed pests. It should be understood that the following examples are merely illustrative and explanatory of the present invention and should not be construed as limiting the scope of protection of the invention.

[0030] Formulation Example 1 The following ingredients were added: 20% chlorfenapyr, 4% chlorfenapyr, 3% sodium salt of naphthalenesulfonic acid / formaldehyde condensate, 3% tristyrene polyoxyethylene ether phosphate, 1.2% magnesium aluminum silicate, 1.0% fumed silica, 5% ethylene glycol, 0.1% benzoic acid, 0.2% polysiloxane, and 0.24% xanthan gum. Deionized water was added to bring the total to 100% by weight. The above ingredients were mixed, dispersed by high-speed shearing for 30 minutes, and then milled in a sand mill until the particle size D90 was less than 5.0 μm. The mixture was then adjusted according to the prescribed dosage to obtain a 24% 2# chlorfenapyr suspension.

[0031] Formulation Example 2 The following ingredients were added: 10% 2# trifluoromethyl sulfadiazine, 30% trifluoromethyl sulfadiazine, 1.5% calcium dodecylbenzenesulfonate, 2.5% polyethylene oxide / polypropylene oxide polymer, 2.5% alkylphenol polyoxyethylene ether sulfate, 1.0% magnesium aluminum silicate, 5% ethylene glycol, 0.1% benzoic acid, 0.22% polysiloxane, and 0.2% xanthan gum. Deionized water was added to bring the total to 100% by weight. The above raw materials were mixed, dispersed by high-speed shearing for 30 minutes, and then milled in a sand mill until the particle size D90 was less than 5.0 μm. The mixture was then adjusted according to the prescribed dosage to obtain a 40% 2# trifluoromethyl sulfadiazine suspension.

[0032] Formulation Example 3 The following ingredients were added: 15% Sulfiflumin, 15% sodium alkyl polyoxyethylene ether sulfonate, 4% alkylphenol formaldehyde resin polyoxyethylene ether, 1.8% magnesium aluminum silicate, 5% ethylene glycol, 0.1% benzoic acid, 0.2% polysiloxane, and 0.25% xanthan gum. Deionized water was added to bring the total to 100% by weight. The above raw materials were mixed, dispersed by high-speed shearing for 30 minutes, and then milled in a sand mill until the particle size D90 was less than 5.0 μm. The mixture was then adjusted according to the prescribed dosage to obtain a 30% 2# Sulfiflumin suspension.

[0033] Formulation Example 4 The following ingredients were added: 20% Spirobudifen (20%), 0.5% sodium dodecyl sulfate, 2.5% calcium lignosulfonate, 4% polyethylene oxide / polypropylene oxide polymer, 2.0% magnesium aluminum silicate, 5% ethylene glycol, 0.1% benzoic acid, 0.2% polysiloxane, and 0.22% xanthan gum. Deionized water was added to bring the total to 100% by weight. The above ingredients were mixed, dispersed by high-speed shearing for 30 minutes, and then milled in a sand mill until the particle size D90 was less than 5.0 μm. The mixture was then adjusted according to the prescribed dosage to obtain a 40% 2# Spirobudifen suspension.

[0034] Formulation Example 5 The following ingredients were added: 20% Flupentiofenox 20%, fatty alcohol polyoxyethylene ether 3%, calcium lignosulfonate 2%, polyvinyl alcohol / polypropylene glycol ether 3%, magnesium aluminum silicate 1.5%, silica 1.5%, propylene glycol 5%, Kathon 0.02%, polysiloxane 0.2%, xanthan gum 0.24%, and deionized water to 100% by weight. The above raw materials were mixed, dispersed by high-speed shearing for 30 minutes, and then milled in a sand mill until the particle size D90 was less than 5.0 μm. The mixture was then adjusted according to the formulation dosage to obtain 40% 2# Flupentiofenox suspension.

[0035] Formulation Example 6 The following ingredients were added: 10% 2# phoxim, 20% phorate, 1% polyethylene oxide / propylene oxide polymer, 4% arylphenol polyoxyethylene ether phosphate, 0.2% potassium dihydrogen phosphate, 0.6% magnesium aluminum silicate, 2.2% silica, 5% propylene glycol, 0.02% Kathon, 0.2% polysiloxane, and 0.22% xanthan gum. Deionized water was added to bring the total to 100% by weight. The above ingredients were mixed, dispersed by high-speed shearing for 30 minutes, and then milled in a sand mill until the particle size D90 was less than 5.0 μm. The mixture was then adjusted according to the prescribed dosage to obtain a 30% 2# phorate suspension.

[0036] The following indoor toxicity test will illustrate the combined indoor toxicity of compound 2# (hereinafter referred to as 2#) with chlorfenapyr, phoxim, dimethoate, pyridaben, carbofuran, amitraz, lambda-cyhalothrin, lime sulfur, sulfur, chlorpyrifos, profenofos, lambda-cyhalothrin, trifluralin, Sulfiflumin, Spirobudifen, Mivorilaner, Modoflaver, Tigolaner, Umifoxolaner, and Flupentiofenox on Tetranychus carmine. The indoor toxicity test method refers to "NY / T 1154.13-2008 Guidelines for Indoor Bioassay of Pesticides - Insecticides Part 13: Leaf Disc Spray Method".

[0037] First, prepare a stock solution of the drug to be tested using acetone, and then prepare five equal concentrations using Tween-80 aqueous solution. Select uniformly grown bean leaves and punch holes to create leaf discs. Place a damp sponge in a petri dish, then place filter paper on top, and place the leaf discs on the filter paper. Place three leaf discs per petri dish. Inoculate 30-50 reared female adult mites of similar size onto each leaf disc. Place the petri dishes in the bottom tray of a potter's spray tower for spraying (1 ml). After the solution settles for 1 minute, remove the dishes and transfer them to rearing conditions. Each treatment is repeated four times. A water treatment is used as a blank control. Check the mortality rate of the spider mites 48 hours after treatment and calculate the mortality rate.

[0038] Experimental data were statistically processed using DPS software to determine correlation coefficients, toxicity regression equations, and lethal median concentrations. The co-toxicity coefficient was calculated using the Sun Yunpei method. The combined effects of the compound pesticides on *Tetranychus carmine* were evaluated using the Sun Yunpei co-toxicity coefficient. A co-toxicity coefficient >120 indicated a synergistic effect, a coefficient between 80 and 120 indicated an additive effect, and a coefficient <80 indicated an antagonistic effect. The results are shown in the table below.

[0039] The combined toxicity of the mixed formulation was determined using Sun Yunpei's co-toxicity coefficient method: ; ; .

[0040] Table 1. Results of virulence determination of adult Tetranychus cinnabarinus mixed with chlorfenapyr nitrile. Drugs and proportions <![CDATA[LC 50 and 95% confidence limit (mg / L) Cotoxicity coefficient (CTC) A 0.136 (0.099-0.176) / B (chlorfenapyr) 6.215 (5.057-7.639) / A:B=100:1 0.099 (0.076-0.129) 138.10 A:B=5:1 0.103 (0.078-0.131) 157.28 A:B=2:1 0.119 (0.092-0.155) 169.61 A:B=1:1 0.139 (0.107-0.181) 191.50 A:B=1:2 0.193 (0.149-0.250) 202.38 A:B=1:5 0.455 (0.349-0.591) 161.94 A:B=1:100 2.964 (2.276-3.853) 145.35 Table 2. Results of toxicity assay of adult Tetranychus cinnabarin with mixture of #2 and trifluralin. Drugs and proportions <![CDATA[LC 50 and 95% confidence limit (mg / L) Cotoxicity coefficient (CTC) A 0.136 (0.099-0.176) / B (Trifluocinonide) 4.342 (3.269-5.554) / A:B=100:1 0.100 (0.077-0.130) 136.86 A:B=5:1 0.102 (0.078-0.133) 158.82 A:B=2:1 0.122 (0.094-0.159) 164.35 A:B=1:1 0.143 (0.109-0.186) 185.00 A:B=1:2 0.230 (0.185-0.312) 166.74 A:B=1:5 0.481 (0.371-0.624) 146.90 A:B=1:100 2.557 (1.969-3.311) 129.98 Table 3. Results of virulence determination of adult Tetranychus cinnabarinus with mixture of #2 and Sulfiflumin. Drugs and proportions <![CDATA[LC 50 and 95% confidence limit (mg / L) Cotoxicity coefficient (CTC) A 0.136 (0.099-0.176) / B (Sulfiflumin) 0.337 (0.211-0.487) / A:B=100:1 0.082 (0.062-0.104) 167.28 A:B=5:1 0.085 (0.066-0.111) 177.02 A:B=2:1 0.087 (0.067-0.113) 194.73 A:B=1:1 0.109 (0.092-0.153) 177.82 A:B=1:2 0.139 (0.107-0.181) 162.71 A:B=1:5 0.179 (0.137-0.232) 151.74 A:B=1:100 0.268 (0.198-0.335) 123.88 Table 4. Results of virulence determination of adult Tetranychus cinnabarinus in combination with #2 and Spirobudifen. Drugs and proportions <![CDATA[LC 50 and 95% confidence limit (mg / L) Cotoxicity coefficient (CTC) A 0.136 (0.099-0.176) / B (Spirobudifen) 5.561 (4.323-6.967) / A:B=100:1 0.089 (0.061-0.103) 153.93 A:B=5:1 0.091 (0.069-0.118) 178.22 A:B=2:1 0.102 (0.078-0.132) 199.01 A:B=1:1 0.158 (0.121-0.206) 168.35 A:B=1:2 0.244 (0.188-0.316) 159.69 A:B=1:5 0.487 (0.376-0.633) 149.22 A:B=1:100 3.045 (2.347-3.959) 130.92 Table 5. Results of virulence determination of adult Tetranychus cinnabarinus in combination with #2 and Flupentiofenox. Drugs and proportions <![CDATA[LC 50 and 95% confidence limit (mg / L) Cotoxicity coefficient (CTC) A 0.136 (0.099-0.176) / B (Flupentiofenox) 0.807 (0.684-0.995) / A:B=100:1 0.101 (0.078-0.131) 135.51 A:B=5:1 0.102 (0.079-0.132) 154.90 A:B=2:1 0.111 (0.084-0.147) 168.91 A:B=1:1 0.126 (0.094-0.158) 185.21 A:B=1:2 0.152 (0.118-0.197) 200.26 A:B=1:5 0.244 (0.188-0.316) 181.86 A:B=1:100 0.487 (0.376-0.633) 158.01 Table 6. Results of virulence determination of adult Tetranychus cinnabarinus mixed with 2# and phoxim. Drugs and proportions <![CDATA[LC 50 and 95% confidence limit (mg / L) Cotoxicity coefficient (CTC) A 0.136 (0.099-0.176) / B (Octylphosphine) 12.203 (9.853-14.729) / A:B=100:1 0.103 (0.081-0.134) 132.50 A:B=5:1 0.106 (0.082-0.137) 154.21 A:B=1:1 0.164 (0.127-0.213) 164.02 A:B=1:5 0.503 (0.388-0.652) 153.56 A:B=1:100 4.832 (3.732-6.263) 134.45 Table 7. Results of virulence determination of adult Tetranychus cinnabarinus with mixture of #2 and dimethoate. Drugs and proportions <![CDATA[LC 50 and 95% confidence limit (mg / L) Cotoxicity coefficient (CTC) A 0.136 (0.099-0.176) / B (Lego) 20.057 (17.258-22.645) / A:B=100:1 0.107 (0.077-0.131) 128.04 A:B=5:1 0.111 (0.086-0.144) 147.24 A:B=1:1 0.161 (0.124-0.209) 167.60 A:B=1:5 0.524 (0.404-0.678) 150.72 A:B=1:100 6.040 (4.665-7.829) 135.53 Table 8. Results of toxicity determination of adult Tetranychus cinnabarinus with mixture of #2 and pyridazine phosmet. Drugs and proportions <![CDATA[LC 50 and 95% confidence limit (mg / L) Cotoxicity coefficient (CTC) A 0.136 (0.099-0.176) / B (pyridazine) 7.989 (6.141-9.774) / A:B=100:1 0.101 (0.078-0.130) 136.05 A:B=5:1 0.111 (0.086-0.144) 147.24 A:B=1:1 0.161 (0.124-0.209) 165.74 A:B=1:5 0.483 (0.373-0.626) 155.63 A:B=1:100 4.027 (3.110-5.220) 126.25 Table 9. Results of virulence determination of adult Tetranychus cinnabarinus mixed with 2# and carbofuran. Drugs and proportions <![CDATA[LC 50 and 95% confidence limit (mg / L) Cotoxicity coefficient (CTC) A 0.136 (0.099-0.176) / B (Butylcarbofuran) 15.647 (13.278-17.983) / A:B=100:1 0.102 (0.079-0.132) 134.31 A:B=5:1 0.104 (0.081-0.136) 156.28 A:B=1:1 0.165 (0.128-0.215) 163.24 A:B=1:5 0.533 (0.411-0.693) 146.74 A:B=1:100 5.739 (4.431-7.464) 128.05 Table 10. Results of virulence determination of adult Tetranychus cinnabarinus mixed with 2# and amitraz. Drugs and proportions <![CDATA[LC 50 and 95% confidence limit (mg / L) Cotoxicity coefficient (CTC) A 0.136 (0.099-0.176) / B (monomethylammonium) 10.411 (8.575-12.203) / A:B=100:1 0.102 (0.079-0.133) 134.31 A:B=5:1 0.109 (0.084-0.141) 150.09 A:B=1:1 0.164 (0.127-0.213) 163.41 A:B=1:5 0.512 (0.395-0.666) 149.49 A:B=1:100 4.714 (3.639-6.131) 126.32 Table 11. Results of toxicity determination of adult Tetranychus cinnabarinus with mixture of #2 and lambda-cyhalothrin. Drugs and proportions <![CDATA[LC 50 and 95% confidence limit (mg / L) Cotoxicity coefficient (CTC) A 0.136 (0.099-0.176) / B (High-efficiency cyhalothrin) 3.779 (2.358-4.935) / A:B=100:1 0.104 (0.080-0.136) 131.60 A:B=5:1 0.115 (0.088-0.149) 141.48 A:B=1:1 0.167 (0.129-0.217) 157.86 A:B=1:5 0.480 (0.369-0.624) 144.20 A:B=1:100 2.300 (1.769-2.988) 129.89 Table 12 Results of virulence determination of adult Tetranychus cinnabarinus in combination with #2 and Mivorilaner Drugs and proportions <![CDATA[LC 50 and 95% confidence limit (mg / L) Cotoxicity coefficient (CTC) A 0.136 (0.099-0.176) / B (Mivorilaner) 0.207 (0.147-0.265) / A:B=100:1 0.099 (0.076-0.129) 137.65 A:B=5:1 0.098 (0.076-0.127) 146.94 A:B=1:1 0.097 (0.075-0.126) 169.42 A:B=1:5 0.122 (0.095-0.159) 155.23 A:B=1:100 0.161 (0.124-0.209) 127.87 Table 13 Results of virulence determination of adult Tetranychus cinnabarinus in combination with #2 and Modoflaner Drugs and proportions <![CDATA[LC 50 and 95% confidence limit (mg / L) Cotoxicity coefficient (CTC) A 0.136 (0.099-0.176) / B (Modoflaner) 0.878 (0.313-1.516) / A:B=100:1 0.100 (0.078-0.131) 136.45 A:B=5:1 0.099 (0.077-0.129) 158.95 A:B=1:1 0.140 (0.108-0.180) 169.18 A:B=1:5 0.299 (0.231-0.386) 153.85 A:B=1:100 0.638 (0.494-0.823) 130.58 Table 14 Results of virulence determination of adult Tetranychus carmineus in combination with #2 and Tigolaner Drugs and proportions <![CDATA[LC 50 and 95% confidence limit (mg / L) Cotoxicity coefficient (CTC) A 0.136 (0.099-0.176) / B(Tigolaner) 0.989 (0.774-1.236) / A:B=100:1 0.100 (0.077-0.129) 137.41 A:B=5:1 0.102 (0.788-0.131) 156.34 A:B=1:1 0.141 (0.109-0.182) 169.74 A:B=1:5 0.322 (0.250-0.416) 150.45 A:B=1:100 0.704 (0.545-0.909) 132.28 Table 15 Results of virulence determination of adult Tetranychus cinnabarinus in combination with #2 and Umifoxolaner Drugs and proportions <![CDATA[LC 50 and 95% confidence limit (mg / L) Cotoxicity coefficient (CTC) A 0.136 (0.099-0.176) / B(Umifoxolaner) 0.731 (0.557-1.034) / A:B=100:1 0.108 (0.083-0.139) 127.32 A:B=5:1 0.116 (0.090-0149) 135.34 A:B=1:1 0.141 (0.104-0.174) 161.95 A:B=1:5 0.245 (0.181-0.303) 172.58 A:B=1:100 0.490 (0.466-1.091) 143.15 Table 16 Results of virulence determination of adult Tetranychus cinnabarinus mixed with #2 and lime sulfur Drugs and proportions <![CDATA[LC 50 and 95% confidence limit (mg / L) Cotoxicity coefficient (CTC) A 0.136 (0.099-0.176) / B (lime sulfur mixture) 2247 (1878-2641) / A:B=100:1 0.080 (0.061-0.103) 171.89 A:B=5:1 0.100 (0.077-0.128) 163.49 A:B=1:1 0.179 (0.138-0.231) 151.62 A:B=1:5 0.588 (0.447-0.746) 138.75 A:B=1:100 10.565 (8.176-13.643) 129.23 Table 17 Results of virulence determination of adult Tetranychus cinnabarinus mixed with sulfur (pair #2) Drugs and proportions <![CDATA[LC 50 and 95% confidence limit (mg / L) Cotoxicity coefficient (CTC) A 0.136 (0.099-0.176) / B (sulfur) 2104 (1764-2483) / A:B=100:1 0.080 (0.062-0.103) 171.04 A:B=5:1 0.100 (0.077-0.129) 162.84 A:B=1:1 0.180 (0.139-0.232) 150.94 A:B=1:5 0.601 (0.465-0.775) 135.86 A:B=1:100 11.011 (8.525-14.224) 123.94 Table 18. Results of toxicity determination of adult Tetranychus carmineus in combination with chlorpyrifos #2. Drugs and proportions <![CDATA[LC 50 and 95% confidence limit (mg / L) Cotoxicity coefficient (CTC) A 0.136 (0.099-0.176) / B (chlorpyrifos) 19.803 (17.574-22.037) / A:B=100:1 0.105 (0.081-0.136) 130.73 A:B=5:1 0.114 (0.088-0.149) 142.61 A:B=1:1 0.166 (0.127-0.216) 162.36 A:B=1:5 0.540 (0.418-0.702) 146.00 A:B=1:100 6.235 (4.827-8.104) 131.15 Table 19 Results of virulence determination of adult Tetranychus cinnabarinus mixed with 2# and profenofos. Drugs and proportions <![CDATA[LC 50 and 95% confidence limit (mg / L) Cotoxicity coefficient (CTC) A 0.136 (0.099-0.176) / B (Profenofos) 7.256 (5.103-9.365) / A:B=100:1 0.104 (0.081-0.136) 131.98 A:B=5:1 0.112 (0.086-0.144) 146.06 A:B=1:1 0.165 (0.128-0.214) 161.52 A:B=1:5 0.537 (0.417-0.695) 138.84 A:B=1:100 3.926 (3.052-5.077) 121.71 Table 20 Results of toxicity determination of adult Tetranychus cinnabarinus in combination with 2# and high-efficiency cypermethrin Drugs and proportions <![CDATA[LC 50 and 95% confidence limit (mg / L) Cotoxicity coefficient (CTC) A 0.136 (0.099-0.176) / B (High-efficiency cypermethrin) 5.863 (4.957-6.889) / A:B=100:1 0.102 (0.079-0.133) 133.79 A:B=5:1 0.082 (0.063-0.106) 146.52 A:B=1:1 0.164 (0.127-0.212) 162.39 A:B=1:5 0.511 (0.396-0.664) 143.05 A:B=1:100 3.389 (2.611-4.396) 122.09 Tables 1 to 20 show that when No. 2 is combined with chlorfenapyr, phoxim, dimethoate, pyridaben, carbofuran, amitraz, lambda-cyhalothrin, lime sulfur, sulfur, chlorpyrifos, profenofos, lambda-cyhalothrin, trifluralin, Sulfiflumin, Spirobudifen, Mivorilaner, Modoflaver, Tigolaner, Umifoxolaner, and Flupentiofenox in a weight ratio range of 100:1 to 1:100, it exhibits a certain synergistic effect on adult Tetranychus carmineus.

[0041] In summary, the synergistic acaricide composition of the present invention has a significant synergistic effect. Compared with single agents, it can effectively reduce the amount of pesticides used, lower the cost of use, protect the environment, and delay the development of pesticide resistance in mites.

[0042] It should be noted that the embodiments described in this invention are exemplary and not exhaustive. The scope of protection of this invention is not limited to the disclosed embodiments. Modifications made without departing from the scope and subjective intent of the described embodiments are all within the scope of protection of this invention.

Claims

1. A synergistic acaricide composition comprising: an active compound (A), said active compound (A) being at least one compound of formula I: (Formula I) In Formula I above, R1 and R2 are each independently selected from hydrogen, halogen, cyano, C1-C4 alkyl or C1-C4 haloalkyl; n is selected from 0 or 1; R3, R4, R5, and R6 are each independently selected from hydrogen, halogen, cyano, nitro, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, or C1-C4 haloalkoxy. And at least one active compound (B), said active compound (B) being selected from: Chlorfenapyr, phoxim, dimethoate, pyridaben, carbofuran, amitraz, lambda-cyhalothrin, lime sulfur, sulfur, chlorpyrifos, profenofos, lambda-cyhalothrin, trifluralin, Sulfiflumin, Spirobudifen, Mivorilaner, Modoflaver, Tigolaner, Umifoxolaner, Flupentiofenox.

2. The synergistic acaricide composition according to claim 1, characterized in that, The active compound (A) is selected from compounds of formula Ia: (Formula Ia).

3. The synergistic acaricide composition according to claim 2, characterized in that, The weight ratio of the active compound (A) to the active compound (B) is 1:100 to 100:

1.

4. The synergistic acaricide composition according to claim 3, characterized in that, The weight ratio of the active compound (A) to the active compound (B) is 5:1 to 1:

5.

5. An acaricide, characterized in that, The acaricide comprises an acaricidal active ingredient and an adjuvant, wherein the acaricidal active ingredient is the synergistic acaricidal composition according to any one of claims 1 to 4.

6. The acaricide according to claim 5, characterized in that, The acaricide formulations include: suspension concentrates, microemulsions, water-dispersible granules, soluble concentrates, dispersible oil suspensions, ultra-low volume liquids, dispersible liquids, soluble colloids, emulsifiable concentrates, water-emulsions, microcapsule suspensions, microcapsule suspension-water emulsions, microcapsule suspension-suspension concentrates, microcapsule suspension-suspension concentrates, suspension emulsions, oils, powders, soluble powders, soluble granules, and wettable powders.

7. The acaricide according to claim 5, characterized in that, The total mass of the acaricidal active ingredient accounts for 1 to 60% of the total mass of the formulation, by weight percentage.

8. The application of a synergistic acaricidal composition in the control of harmful mites, characterized in that, It comprises the synergistic acaricidal composition as described in any one of claims 1-4.

9. The application according to claim 8, wherein the mites include wheat long-legged spider, wheat round spider, cotton carmine spider mite, vegetable spider mite, hawthorn spider mite, citrus pterocaryon, citrus rust mite, apple spider mite, two-spotted spider mite, gall mite, flour mite, tea short-bearded mite, alfalfa moth mite, and citrus tumor mite.

Images