Fungicidal mixtures comprising substituted quinazolinyl quinolines

Abstract

The invention relates to fungicidal mixtures comprising at least one substituted quinoline (compound I) and at least one active compound II in a weight ratio of 15: 1 to 1: 15.

Description

[0001] This invention relates to an antifungal mixture comprising the following as an active ingredient:

[0002] 1) At least one active compound having formula I, or its N-oxide, or an agriculturally useful salt.

[0003]

[0004] in

[0005] R 1 It is H or CH3;

[0006] R 2 Selected from CN, CH3, CH(CH3)2, CH2CH=CH2, CH2CCH;

[0007] X 1 Selected from H, Cl, F, CH3;

[0008] X 2 Selected from H, F, and OCH3;

[0009] Y is Cl, F, or CH3;

[0010] And the following items as component 1):

[0011] 2) At least one active compound II selected from the group consisting of:

[0012] - Respiratory inhibitors I: azoxystrobin, pyraclostrobin, tetrazoxystrobin, pyridabenamide, pyridabenamide (A.2.6Ic); boscalid, fluopyram, isopyram, fluopyram hydroxylamine, indapoxetine, fluindoxetine, triflupyridamine, fluazinam;

[0013] - Sterol biosynthesis inhibitors (SBI fungicides): difenoconazole, prothioconazole, chlorfenapyr, methyl 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propionate, methyl 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propionate;

[0014] - Nucleic acid synthesis inhibitor: Isopropylquinoline;

[0015] -An amino acid and protein synthesis inhibitor: pyrimethanil;

[0016] - Signal transduction inhibitor: fludioxonil;

[0017] - Inhibitors with multi-site action: sulfur, dithiazolinone, Cu,

[0018] - Cell wall synthesis inhibitor: tricyclazole;

[0019] - Plant defense inducers: isothiazine, cyclohexane-calcium; phosphite and its salts;

[0020] -Mechanism of action unknown: dichlorvos, flusulfanilamide, tebufloquin, fluoxetine;

[0021] - Insecticidal compounds with unknown or uncertain modes of action: fluopyram;

[0022] The weight ratio of these components is 1:15 to 15:1.

[0023] The present invention also relates to the use of the mixture and to a method of using the mixture to control pathogenic fungi in plants.

[0024] Practical agricultural experience has shown that, in controlling harmful fungi, repeated and singular application of a single active compound often leads to rapid selection of fungal strains that develop natural or adaptive resistance to the active compound in question. These fungi can then no longer be effectively controlled with the active compound in question.

[0025] To reduce the risk of selection by resistant fungal strains, mixtures of different active compounds are commonly used to control harmful fungi. By combining active compounds with different mechanisms of action, a relatively long period of successful control can be ensured.

[0026] The object of the present invention is to provide compositions that, from the perspective of effective resistance management and effective control of plant pathogenic harmful fungi, have improved antifungal activity (synergistic mixture) at the lowest possible application rate and with a reduced total amount of applied active compound, and particularly a broadened activity spectrum for certain indications.

[0027] Therefore, we have found that this objective is achieved by compositions as defined herein, which comprise at least one compound I and at least one compound II.

[0028] Furthermore, we found that simultaneous (i.e., combined or separate) application of Compound I and Compound II, or sequential application of Compound I and Compound II, allows for better control of harmful fungi compared to the control that may be achieved using only the individual compounds (synergistic mixture). Compound I and / or Compound II can exist in different crystal variants (which may differ in biological activity).

[0029] The term "compound I" refers to a compound having formula I.

[0030] In the definitions of variables given above, the collective terminology that typically represents the substituents under discussion is used. The term "C"n -C m "Indicates the number of possible carbon atoms in the substituent or substituent moiety discussed in each case."

[0031] The scope of this invention includes mixtures of (R)- and (S)- isomers of compound I and / or II and / or III having one or more chiral centers, as well as racemic mixtures. Due to the hindered rotation of asymmetric substituents, hindered transisomers of active compound I and / or II and / or III may exist. They also form part of the subject matter of this invention.

[0032] Compound I, its preparation, and its use as fungicidal active compounds are described in WO 2023 / 011957.

[0033] For example, the formation of compound I from a compound having formula 2 is suitable to be carried out by alkylation or acylation in the presence of a lower alkoxide or hydride such as potassium or sodium. Di-lower alkyl sulfates can also be used to achieve said alkylation or acylation, as described in US 3,625,959.

[0034] The cyclic compound having Formula 2 can be prepared from ketamine compound 1 by reacting it with acetone (1a) in the presence of ammonium acetate. In some cases, the presence of an acid such as p-toluenesulfonic acid (p-TsOH), pyridinium p-toluenesulfonic acid, sulfuric acid, or acetic acid increases the yield (for precedents, see, for example, Chemistry Select (2018), 3(32), 9388-9392 and Organic & Biomolecular Chemistry (2003), 1(2), 367-372).

[0035]

[0036] Compounds having Formula 1 are commercially available or can be obtained by means of the general route outlined in the following schemes, such as the oxidation of amino alcohol 7 by manganese dioxide, as described in Inorganica Chimica Acta [Inorganic Chemistry Journal] (2012), 382, ​​72-78, WO 2000038618, CN 107879989 A, Chinese Science Bulletin [Science Bulletin] (2010), 55(25), 2817-2819.

[0037] Compounds having formula 7 can be obtained by hydrogenating the corresponding nitro alcohol 6 using RANEY®-nickel catalysis, as described in WO2000038618, Inorganica Chimica Acta [Chinese Journal of Inorganic Chemistry] (2012), 382, ​​72-78.

[0038] 2-Nitro alcohol 6 can be prepared as described by Knochel and colleagues (Angew. Chem., Int. Ed. [Germany Angewandte Chemie International Edition], 2002, 41, 1610) by iodine-magnesium exchange mediated by isopropylphenyl magnesium bromide and subsequent addition with a commercially available nitrobenzaldehyde derivative 5.

[0039] Option 1

[0040]

[0041] In one embodiment, the present invention relates to a mixture comprising, as component 1), at least one active compound having formula I, or its N-oxide, or an agriculturally useful salt, wherein:

[0042] R 1 It is H, CH3

[0043] R 2 Selected from CN, CH3, CH(CH3)2, CH2CH=CH2, CH2CCH;

[0044] X 1 Selected from H, Cl, F, CH3;

[0045] X 2 Selected from H, F, and OCH3,

[0046] Y is F.

[0047] In another embodiment, the present invention relates to a mixture comprising, as component 1), at least one active compound having formula I, or its N-oxide, or an agriculturally useful salt, wherein:

[0048] R 1 It is H, CH3

[0049] R 2 Selected from CN, CH2CH=CH2, CH2CCH;

[0050] X 1 Selected from H and F;

[0051] X 2 Selected from H and F,

[0052] Y is F.

[0053] In another embodiment, the present invention relates to a mixture comprising, as component 1), at least one active compound having formula I, or its N-oxide, or an agriculturally useful salt, wherein:

[0054] R 1 It is H, CH3

[0055] R 2 Selected from CN, CH2CH=CH2, CH2CCH;

[0056] X 1 Selected from F;

[0057] X 2 Selected from F,

[0058] Y is F.

[0059] The particularly preferred active compound I is selected from the group consisting of compounds I-1 to I-25:

[0060] I-1: 4-(8-fluoroquinolin-3-yl)-2,2-dimethylquinazolin-1(2H-formonitrile)

[0061] I-2: 8-Chloro-1,2,2-trimethyl-4-(quinolin-3-yl)-1,2-dihydroquinazolin

[0062] I-3: 8-Fluoro-4-(8-Fluoro-4-methylquinolin-3-yl)-1,2,2-trimethyl-1,2-dihydroquinazolin

[0063] I-4: 8-Chloro-1,2,2-trimethyl-4-(8-methylquinolin-3-yl)-1,2-dihydroquinazolin

[0064] I-5: 8-Fluoro-1,2,2-trimethyl-4-(8-methylquinolin-3-yl)-1,2-dihydroquinazolin

[0065] I-6: I-2: 8-Chloro-1,2,2-trimethyl-4-(8-methylquinolin-3-yl)-1,2-dihydroquinazolin

[0066] I-7: 2,2-Dimethyl-4-(quinolin-3-yl)quinazolin-1(2H)-formonitrile

[0067] I-8: 4-(8-chloroquinoline-3-yl)-2,2-dimethylquinazolin-1(2H-formonitrile)

[0068] I-9: 8-Fluoro-4-(8-fluoroquinolin-3-yl)-2,2-dimethylquinazolin-1(2H)-formonitrile

[0069] I-10: 8-Fluoro-4-(8-Fluoro-4-methylquinolin-3-yl)-2,2-dimethylquinazolin-1(2H-formonitrile

[0070] I-11: 8-Fluoro-2,2-dimethyl-4-(8-methylquinolin-3-yl)quinazolin-1(2H)-formonitrile

[0071] I-12: 8-Chloro-2,2-dimethyl-4-(8-methylquinolin-3-yl)quinazolin-1(2H)-formonitrile

[0072] I-13: 8-Fluoro-2,2-dimethyl-4-(quinolin-3-yl)quinazolin-1(2H)-formonitrile

[0073] I-14: 8-Chloro-4-(8-chloroquinoline-3-yl)-2,2-dimethylquinazolin-1(2H)-formonitrile

[0074] I-15: 7,8-Difluoro-1,2,2-trimethyl-4-(quinolin-3-yl)-1,2-dihydroquinazolin

[0075] I-16: 4-(8-chloroquinoline-3-yl)-8-fluoro-2,2-dimethylquinazolin-1(2H)-formonitrile

[0076] I-17: 8-Fluoro-4-(8-fluoroquinolin-3-yl)-1-isopropyl-2,2-dimethyl-1,2-dihydroquinazolin

[0077] I-18: 2,2-Dimethyl-4-(8-methylquinolin-3-yl)quinazolin-1(2H)-formonitrile

[0078] I-19: 1-Allyl-7,8-difluoro-4-(8-fluoro-4-methylquinolin-3-yl)-2,2-dimethyl-1,2-dihydroquinazolin

[0079] I-20: 4-(8-fluoro-4-methylquinoline-3-yl)-2,2-dimethylquinazolin-1(2H-formonitrile)

[0080] I-21: 7,8-Difluoro-4-(8-fluoro-4-methylquinolin-3-yl)-1,2,2-trimethyl-1,2-dihydroquinazolin

[0081] I-22: 8-Fluoro-4-(8-fluoroquinolin-3-yl)-1,2,2-trimethyl-1,2-dihydroquinazolin

[0082] I-23: 7,8-Difluoro-4-(8-fluoro-4-methylquinolin-3-yl)-2,2-dimethyl-1-(prop-2-yn-1-yl)-1,2-dihydroquinazolin

[0083] I-24: 4-(8-fluoro-4-methylquinoline-3-yl)-7-methoxy-1,2,2,8-tetramethyl-1,2-dihydroquinazolinoline

[0084] I-25: 4-(8-fluoroquinoline-3-yl)-7-methoxy-1,2,2,8-tetramethyl-1,2-dihydroquinazoline.

[0085] Also preferred are mixtures comprising at least one active compound as component 2), the at least one active compound being selected from respiratory inhibitors, more preferably from compounds such as: azoxystrobin, pyraclostrobin, tetrazoxystrobin, pyridabenamide, pyridabenamide; boscalidamide, fluopyram, isothiazamide, fluopyram, indopyram, fluindazole, triflupyridamine, fluazinam, and even more preferably from compounds such as azoxystrobin, pyraclostrobin, tetrazoxystrobin, boscalidamide, fluopyram, isothiazamide, fluopyram, indopyram, fluindazole, and fluazinam. The most preferred mixture comprises at least one active compound as component 2), the at least one active compound being selected from pyraclostrobin, tetrazoxystrobin, boscalidamide, and fluopyram.

[0086] Also preferred are mixtures comprising at least one active compound as component 2), the at least one active compound being selected from sterol biosynthesis inhibitors (SBI fungicides), more preferably from compounds such as difenoconazole, prothioconazole, chlorfluazuron, methyl 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propionate, methyl 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propionate, and even more preferably from compounds such as difenoconazole, prothioconazole, and chlorfluazuron. The most preferred mixture comprises chlorfluazuron as component 2).

[0087] Also preferred are mixtures comprising at least one active compound selected from nucleic acid synthesis inhibitors as component 2). The most preferred mixture comprises isopropylquinoline as component 2).

[0088] Also preferred are mixtures comprising at least one active compound as component 2), wherein the at least one active compound is selected from amino acids and protein synthesis inhibitors. The most preferred mixture comprises pyrimethanil as component 2).

[0089] Also preferred are mixtures comprising at least one active compound as component 2), wherein the at least one active compound is selected from signal transduction inhibitors. The most preferred mixture comprises fludioxonil as component 2).

[0090] More preferably, it is a mixture comprising at least one active compound as component 2), wherein the at least one active compound is selected from inhibitors having multi-site activity. The most preferred mixture comprises sulfur, dithiazolinone, and Cu as component 2).

[0091] More preferably, it is a mixture comprising at least one active compound selected from cell wall synthesis inhibitors as component 2). The most preferred mixture comprises tricyclazole as component 2).

[0092] Also preferred are mixtures comprising at least one active compound as component 2), wherein the at least one active compound is selected from plant defense inducers. Preferred mixtures comprise isothiazamine, calcium cyclohexane, phosphite, and their salts as component 2). Most preferred mixtures comprise calcium cyclohexane as component 2.

[0093] Also preferred are mixtures comprising at least one active compound as component 2), wherein the at least one active compound is selected from compounds with unknown modes of action. Preferred mixtures comprise dichlorothiazide, flusulfanilamide, isobutylethoxyquinoline, and fluoxazine as component 2). Most preferred mixtures comprise fluoxazine as component 2.

[0094] Also preferred are mixtures comprising at least one active compound as component 2), wherein the at least one active compound is selected from insecticidal compounds whose mode of action is unknown or uncertain. The most preferred mixture comprises fluopyram as component 2).

[0095] Particularly preferred are the following binary mixtures A1-1 to A1-825 listed in Table A1:

[0096] Table A1:

[0097]

[0098]

[0099]

[0100]

[0101]

[0102]

[0103]

[0104]

[0105]

[0106]

[0107]

[0108]

[0109]

[0110]

[0111]

[0112]

[0113]

[0114]

[0115]

[0116]

[0117]

[0118]

[0119]

[0120]

[0121]

[0122]

[0123]

[0124]

[0125]

[0126]

[0127]

[0128]

[0129]

[0130] In one embodiment, the weight ratio of compound I to compound II in mixtures A1-1 to A1-825 of Table A is between 15:1 and 1:15.

[0131] In another embodiment, the weight ratio of compound I to compound II in mixtures A1-1 to A1-825 of Table A is between 14:1 and 1:14.

[0132] In one embodiment, the weight ratio of compound I to compound II in mixtures A1-1 to A1-825 of Table A is between 13:1 and 1:13.

[0133] In one embodiment, the weight ratio of compound I to compound II in mixtures A1-1 to A1-825 of Table A is between 12:1 and 1:12.

[0134] In one embodiment, the weight ratio of compound I to compound II in mixtures A1-1 to A1-825 of Table A is between 11:1 and 1:11.

[0135] In one embodiment, the weight ratio of compound I to compound II in mixtures A1-1 to A1-825 of Table A is between 10:1 and 1:10.

[0136] In one embodiment, the weight ratio of compound I to compound II in mixtures A1-1 to A1-825 of Table A is between 9:1 and 1:9.

[0137] In one embodiment, the weight ratio of compound I to compound II in mixtures A1-1 to A1-825 of Table A is between 8:1 and 1:8.

[0138] In one embodiment, the weight ratio of compound I to compound II in mixtures A1-1 to A1-825 of Table A is between 7:1 and 1:7.

[0139] In one embodiment, the weight ratio of compound I to compound II in mixtures A1-1 to A1-825 of Table A is between 6:1 and 1:6.

[0140] In one embodiment, the weight ratio of compound I to compound II in mixtures A1-1 to A1-825 of Table A is between 5:1 and 1:5.

[0141] In one embodiment, the weight ratio of compound I to compound II in mixtures A1-1 to A1-825 of Table A is between 4:1 and 1:4.

[0142] In one embodiment, the weight ratio of compound I to compound II in mixtures A1-1 to A1-825 of Table A is between 3:1 and 1:3.

[0143] In one embodiment, the weight ratio of compound I to compound II in mixtures A1-1 to A1-825 of Table A is between 2:1 and 1:2.

[0144] In one embodiment, the weight ratio of compound I to compound II in mixtures A1-1 to A1-825 of Table A is 1:1.

[0145] Preferably, in addition to at least one compound I and at least one compound II, the binary mixtures above also contain at least one additional active compound III as component 3), thereby producing ternary mixtures. Preferably, components 1) and 2) or all three components 1), 2) and 3) in these mixtures are present in synergistically effective amounts.

[0146] Therefore, one embodiment relates to a ternary mixture comprising the following as an active component:

[0147] 1) As defined above,

[0148] 2) As defined above,

[0149] And the following items as components:

[0150] 3) At least one active compound III, wherein the at least one active compound III is selected from groups A) to O):

[0151] A) Respiratory depressants

[0152] -in Q oComplex III inhibitors at the site (QoI, C3, FRAC convention; www.frac.info): azoxystrobin (A.1.1), fenoxystrobin (A.1.2), eugenol (A.1.3), azoxystrobin (A.1.4), tebufenoxam (A.1.5), tebufenoxam (A.1.6), fenoxystrobin (A.1.7), flufenoxystrobin (A.1.8), azoxystrobin (A.1.9), mandestrobin. (A.1.10), fenoxyfen (A.1.11), oxadiazon (A.1.12), azoxystrobin (A.1.13), pyraclostrobin (A.1.14), azoxystrobin (A.1.15), azoxystrobin (A.1.16), oxadiazon (A.1.17), 2-(2-(3-(2,6-dichlorophenyl)-1-methyl-allylaminooxymethyl)-phenyl)-2-methoxyimino-N-methylacetamide (A.1.18), pyraclostrobin (A.1.19), chlorpyrifos (triclopyricarb / chlorodincarb) (A.1.20), Oxazolidinone (A.1.21), Imidacloprid (A.1.21), Methyl-N-[2-[(1,4-dimethyl-5-phenyl-pyrazol-3-yl)oxymethyl]phenyl]-N-methoxy-carbamate (A.1.22), Tetracyclazole (A.1.25; member of MoA subgroup A), (Z,2E)-5-[1-(2,4-dichlorophenyl)pyrazol-3-yl]oxy-2-methoxyimino- N,3-Dimethyl-pentan-3-enamide (A.1.34), (Z,2E)-5-[1-(4-chlorophenyl)pyrazol-3-yl]oxy-2-methoxyimino-N,3-dimethyl-pentan-3-enamide (A.1.35), pyrimethanil (A.1.36), pyraclostrobin (A.1.37), 2-(o-((2,5-dimethylphenyl-oxymethylene)phenyl)-3-methoxymethyl acrylate (A.1.38);

[0153] -in Q i Complex III inhibitors at the site (QiI, C4): cyazofamid (A.2.1), indoxofensulfuron (A.2.2), 2-methylpropionic acid [(6S,7R,8R)-8-benzyl-3-[(3-hydroxy-4-methoxy-pyridin-2-carbonyl)amino]-6-methyl-4,9-dioxo-1,5-dioxonon-7-yl] ester (A.2.3), fenpicoxamid (A.2.4), pyridine (A.2.5), metarylpicoxamid (A.2.6);

[0154] - Complex II inhibitors (SDHI, C2): Benzac-methyl (A.3.1), Benzoflufenicol (A.3.2), Bifenazate (A.3.3), Cyclopyr (A.3.4), Mancozeb (A.3.5), Mefenoxam (A.3.6), Fluopyram (A.3.7), Fluopyram (A.3.8), Fluopyram (A.3.9), Furazolidone (A.3.10), Isopropylthiamethoxam (A.3.11), Pyraclostrobin (A.3.12), Mefenoxam (A.3.13), Oxycarboxim (A.3.14), Fluopyram (A.3.15), Pyraclostrobin (A.3.16), Fluopyram (A.3.17) .3.17), bifenazate (A.3.18), fluoxastrobin (A.3.19), chlorothalonil (A.3.20), thifluzamide (A.3.21), inpyrfluxam (A.3.22), pyrapropoyne (A.3.23), fluoxastrobin (A.3.28), N-[2-[2-chloro-4-(trifluoromethyl)phenoxy]phenyl]-3-(difluoromethyl)-5-fluoro-1-methyl-pyrazole-4-carboxamide (A.3.29), (E)-2-[2-[(5-cyano-2-methyl-phenoxy)methyl]phenyl]-3-methoxy-prop-2- Methyl acrylate (A.3.30), isoflucypram (A.3.31), 2-(difluoromethyl)-N-(1,1,3-trimethyl-indane-4-yl)pyridine-3-carboxamide (A.3.32), 2-(difluoromethyl)-N-[(3R)-1,1,3-trimethyl-indane-4-yl]pyridine-3-carboxamide (A.3.33), 2-(difluoromethyl)-N-(3-ethyl-1,1-dimethyl-indane-4-yl)pyridine-3-carboxamide (A.3.34), 2-(difluoromethyl)-N-[(3R)-3-ethyl-1,1-dimethyl-indane-4-yl]pyridine-3-carboxamide Amines (A.3.35), 2-(difluoromethyl)-N-(1,1-dimethyl-3-propyl-indamino-4-yl)pyridine-3-carboxamide (A.3.36), 2-(difluoromethyl)-N-[(3R)-1,1-dimethyl-3-propyl-indamino-4-yl]pyridine-3-carboxamide (A.3.37), 2-(difluoromethyl)-N-(3-isobutyl-1,1-dimethyl-indamino-4-yl)pyridine-3-carboxamide (A.3.38), 2-(difluoromethyl)-N-[(3R)-3-isobutyl-1,1-dimethyl-indamino-4-yl]pyridine-3-carboxamide (A.3.39), trifluoropyridineamine (A.3.24);

[0155] - Other respiratory depressants: diflubenzuron (A.4.1); nitrophenyl derivatives: acaricides (A.4.2), fenpropathrin (A.4.3), fenpropathrin (A.4.4), fluazinam (A.4.5), fenpropathrin (A.4.6), pyrimethanil (A.4.7); organometallic compounds: triphenyltin salts, such as triphenyltin acetate (A.4.8), triphenyltin chloride (A.4.9), or triphenyltin hydroxide (A.4.10); silthiamethoxam (A.4.11);

[0156] - Quinone-extraquinone inhibitor binding type (QoSI; C8): Azoxystrobin (A.5.1);

[0157] B) Sterol biosynthesis inhibitors (SBI fungicides)

[0158] -C14 demethylase inhibitors (DMI, G1): Triazoles: Penticazole (B.1.1), Bifenthrin (B.1.2), Fenoxacillin (B.1.3), Cycloconazole (B.1.4), Oxadiazon (B.1.5), Tebuconazole (B.1.6), Tebuconazole-M (B.1.7), Flutriafol (B.1.8), Cyproconazole (B.1.9), Fluquinazole (B.1.10), Flusilazole (B.1.11), Tebuconazole (B.1.12), Hexaconazole (B.1.13), Ammonium oxychloride (B.1.14), Izoxystrobin (B.1.15), Imidacloprid (B.1.17), Cyproconazole (B.1.18), Oxamidazole (B.1.19), Paclobutrazol (B.1.20), Tebuconazole (B.1.21), Propiconazole (B.1.22), Prothioconazole (B.1.23), Silosovirazole (B.1.24), Tebuconazole (B.1.25), Flufenoxuron (B.1.26) .1.26), triadimefon (B.1.27), azoxystrobin (B.1.28), cymoxanil (B.1.29), uniconazole (B.1.30), 2-(2,4-difluorophenyl)-1,1-difluoro-3-(tetrazol-1-yl)-1-[5-[4-(2,2,2-trifluoroethoxy)phenyl]-2-pyridyl]prop-2-ol (B.1.31), 2-(2,4-difluorophenyl)-1,1-difluoro-3-(tetrazol-1-yl)-1-[5-[4-(trifluoromethoxy)phenyl]-2-pyridyl]prop-2-ol (B.1.32), fluopyram (B.1.33), isothiazine Fluopyram (ipfentrifluconazole) (B.1.37), chlorfenapyr (B.1.38), (2R)-2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1,2,4-triazol-1-yl)prop-2-ol, (2S)-2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1,2,4-triazol-1-yl)prop-2-ol, 2-(chloromethyl)-2-methyl-5-(p-tolylmethyl)-1-(1,2,4-triazol-1-ylmethyl)cyclopentanol (B.1.43); imidazoles: acetamiprid (B.1.43) .1.44), isoprothiolane (B.1.45), prochloraz (B.1.46), fluconazole (B.1.47); pyrimidines, pyridines, piperazines: chlorophenylpyrimidinol (B.1.49), pyridabenoxime (B.1.50), azithromycin (B.1.51), [3-(4-chloro-2-fluoro-phenyl)-5-(2,4-difluorophenyl)isoxazol-4-yl]-(3-pyridyl)methanol (B.1.52), 4-[[6-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1,2,4-triazol-1-yl)propyl]-3-pyridyl]oxy]benzonitrile (B.1.53), 2-[6-(4-bromophenoxy)-2-(trifluoromethyl)-3-pyridyl]-1-(1,2,4-triazol-1-yl)prop-2-ol (B.1.54), 2-[6-(4-chlorophenoxy)-2-(trifluoromethyl)-3-pyridyl]-1-(1,2,4-triazol-1-yl)prop-2-ol (B.1.55), methyl 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propionate (B.1.56), methyl 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propionic acid (B.1.57);

[0159] -δ14-reductase inhibitors (G2): 4-dodecyl-2,6-dimethylmorpholine (aldimorph) (B.2.1), morpholine (B.2.2), morpholine acetate (B.2.3), butylmorpholine (B.2.4), clindamycin (B.2.5), benzyl sulfadiazine (B.2.6), fenvalerate (B.2.7), spirocyclophosphamide (B.2.8);

[0160] -3-Ketoreductase inhibitors: Cyclopyridamole (B.3.1), Amifenopyram (B.3.2);

[0161] - Other sterol biosynthesis inhibitors: chlorfenapyrazole (B.4.1);

[0162] C) Nucleic acid synthesis inhibitors

[0163] -RNA polymerase I inhibitors (A1): Benalaxyl (C.1.1), Benalaxyl-M (C.1.2), Kiralaxyl (C.1.3), Metalaxyl (C.1.4), Metalaxyl-M (C.1.5), Furazolidone (C.1.6), Oxyxamic acid (C.1.7);

[0164] Other nucleic acid synthesis inhibitors (A2 to A5): oxamyl (C.2.1), octathiazoline (C.2.2), oxaquinic acid (C.2.3), ethirimol sulfonate (C.2.4), 5-fluorocytosine (C.2.5), 5-fluoro-2-(p-tolylmethoxy)pyrimidin-4-amine (C.2.6), 5-fluoro-2-(4-fluorophenylmethoxy)pyrimidin-4-amine (C.2.7), 5-fluoro-2-(4-chlorophenylmethoxy)pyrimidin-4-amine (C.2.8); DHODH inhibitors: isopyram (C.2.9), fluopyram (C.2.10);

[0165] D) Inhibitors of cell division and cytoskeleton

[0166] - Microtubule polymerization inhibitors (MBC, B1): Benomyl (D.1.1), Carbendazim (D.1.2), Mefenoxam (D1.3), Thiophanate-methyl (D.1.4), Methylthiophanate (D.1.5), Pyridachlometyl (D.1.6), N-ethyl-2-[(3-ethynyl-8-methyl-6-quinolinyl)oxy]butyramide (D.1.8), N-ethyl-2-[(3-ethynyl-8-methyl-6-quinolinyl)oxy]-2-methylthioalkyl-acetamide (D.1.9), 2-[(3-ethynyl-8-methyl-6-quinolinyl)oxy]-N-(2-fluoroethyl)butyramide (D.1.10), 2-[(3-ethynyl-8-methyl-6-quinolinyl)oxy]-N-(2- 2-(2-fluoroethyl)-2-methoxy-acetamide (D.1.11), 2-[(3-ethynyl-8-methyl-6-quinolinyl)oxy]-N-propyl-butyramide (D.1.12), 2-[(3-ethynyl-8-methyl-6-quinolinyl)oxy]-2-methoxy-N-propyl-acetamide (D.1.13), 2-[(3-ethynyl-8-methyl-6-quinolinyl)oxy]-2-methylthioalkyl-N-propyl-acetamide (D.1.14), 2-[(3-ethynyl-8-methyl-6-quinolinyl)oxy]-N-(2-fluoroethyl)-2-methylthioalkyl-acetamide (D.1.15), 4-(2-bromo-4-fluoro-phenyl)-N-(2-chloro-6-fluoro-phenyl)-2,5-dimethyl-pyrazole-3-amine (D.1.16);

[0167] Other cell division inhibitors (B2 to B7): Ethiocarb (D.2.1), Thiamethoxam (D.2.2), Pendimethomorph (D.2.3), Fluopyram (D.2.4), Benzoylamidone (D.2.5), Benomyl (D.2.6), Pyriofenone (D.2.7), Cyazofamid (D.2.8); Fluopyram (D.2.9);

[0168] E) Inhibitors of amino acid and protein synthesis

[0169] - Methionine synthesis inhibitors (D1): Azoxystrobin (E.1.1), Azoxystrobin (E.1.2), Pyrimethanil (E.1.3);

[0170] - Protein synthesis inhibitors (D2 to D5): blastomycin-S (E.2.1), kasugamycin (E.2.2), kasugamycin hydrochloride hydrate (E.2.3), midomycin (E.2.4), streptomycin (E.2.5), oxytetracycline (E.2.6);

[0171] F) Signal transduction inhibitors

[0172] -MAP / histidine kinase inhibitors (E2 and E3): iprodione (F.1.2), procymidone (F.1.3), vinclozolin (F.1.4), fludioxonil (F.1.5);

[0173] -Mechanism unknown (E1): Quinoxaline (F.2.1), Propoxyquin (F.2.2);

[0174] G) Lipid and membrane synthesis inhibitors

[0175] - Phospholipid biosynthesis inhibitors (F2): Kefensan (G.1.1), Isoprothiolane (G.1.2), Dimethoate (G.1.3), Isoprothiolane (G.1.4);

[0176] -Lipid peroxidation (F3): chloronitrobenzene (G.2.1), pentachloronitrobenzene (G.2.2), tetrachloronitrobenzene (G.2.3), methyl thiophanate (G.2.4), biphenyl (G.2.5), dimethoate (G.2.6), chlorpyrifos (G.2.7);

[0177] - Compounds and fatty acids (F4) that affect cell membrane permeability: cymoxanil (G.4.1);

[0178] -Oxidized sterol-binding protein inhibitors (OSBPI, F9): Fluoxapiprolin (G.5.1), Fluoxapiprolin (G.5.3), 4-[1-[2-[3-difluoromethyl-5-methyl-pyrazole-1-yl]acetyl]-4-piperidinyl]-N-tetrahydronaphthyl-1-yl-pyridin-2-carboxamide (G.5.4), 4-[1-[2-[3,5-bis(difluoromethyl)]acetyl]-4-piperidinyl]-N-tetrahydronaphthyl-1-yl-pyridin-2-carboxamide [Pyrazol-1-yl]acetyl]-4-piperidinyl]-N-tetrahydronaphth-1-yl-pyridin-2-carboxamide (G.5.5), 4-[1-[2-[3-(difluoromethyl)-5-(trifluoromethyl)pyrazol-1-yl]acetyl]-4-piperidinyl]-N-tetrahydronaphth-1-yl-pyridin-2-carboxamide (G.5.6), 4-[1-[2-[5-cyclopropyl-3-(difluoromethyl)pyrazol-1-yl]acetyl]-4- [piperidinyl]-N-tetrahydronaphth-1-yl-pyridin-2-carboxamide (G.5.7), 4-[1-[2-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]acetyl]-4-piperidinyl]-N-tetrahydronaphth-1-yl-pyridin-2-carboxamide (G.5.8), 4-[1-[2-[5-(difluoromethyl)-3-(trifluoromethyl)pyrazol-1-yl]acetyl]-4-piperidinyl]-N-tetrahydronaphth-1-yl] 4-pyridine-2-carboxamide (G.5.9), 4-[1-[2-[3,5-bis(trifluoromethyl)pyrazole-1-yl]acetyl]-4-piperidinyl]-N-tetrahydronaphth-1-yl-pyridine-2-carboxamide (G.5.10), (4-[1-[2-[5-cyclopropyl-3-(trifluoromethyl)pyrazole-1-yl]acetyl]-4-piperidinyl]-N-tetrahydronaphth-1-yl-pyridine-2-carboxamide (G.5.11);

[0179] H) Inhibitors with multi-site action

[0180] -Inorganic active substances (MO1, MO2): Bordeaux mixture (H.1.1), copper (H.1.2), copper acetate (H.1.3), copper hydroxide (H.1.4), copper oxychloride (H.1.5), basic copper sulfate (H.1.6), sulfur (H.1.7);

[0181] -Thiocarbamates and dithiocarbamates (M03): ferric sulfate (H.2.1), mancozeb (H.2.2), mancozeb (H.2.3), thiamethoxam (H.2.4), mancozeb (H.2.5), methyl mancozeb (H.2.6), thiram (H.2.7), mancozeb (H.2.8), thiram (H.2.9), thiamethoxam zinc (H.2.10);

[0182] - Organochlorine compounds (M04, M05, M06, M08): Dichlorophenoxyacetic acid (H.3.1), Chlorothalonil (H.3.2), Captan (H.3.3), Captan (H.3.4), Captan (H.3.5), Bacteriostatic agent (H.3.6), Dichlorophenol (H.3.7), Hexachlorobenzene (H.3.8), Pentachlorophenol (H.3.9) and its salts, Tetrachlorophthalide (H.3.10), Para-methyl thiophanate (H.3.11);

[0183] -Guinea and others (M07, M09, M10; M11, M12): Guanidine (H.4.1), dextrin (H.4.2), dextrin free base (H.4.3), guazatine (H.4.4), guazatine-acetate (H.4.5), guazatamine (H.4.6), guazatamine triacetate (H.4.7), guazatamine trioctylbenzene sulfonate (H.4.8), dithiazolinone (H.4.9), 2,6-dimethyl-1H,5H-[1,4]dithiacino[2,3-c:5,6-c']dipyrrole-1,3,5,7(2H,6H)-tetraone (H.4.10), zofuran (H.4.11), sulfadiazine (H.4.12), chlorpyrifos (H.4.13);

[0184] I) Cell wall synthesis inhibitors

[0185] - Dextran synthesis inhibitor: Polyoxin (I.1.1); Chitosan synthase inhibitor (H4): Polyoxin B (I.1.2);

[0186] - Melanin synthesis inhibitors (I1 to I3): Trihydroxynaphthalene reductase inhibitors (MBI-R; I1) cycloquinone (I.2.1), tricyclazole (I.2.2); Dehydratase inhibitors (MBI-D, I2); propiconazole (I.2.3), cyhalofop-p-ethyl (I.2.4), cyazofamid (I.2.5); Polyketide synthase inhibitors (MBI-P, I3): tolprocarb (I.2.6);

[0187] - Cellulose synthase inhibitors (H5): dimethomorph (I.3.1), flumethomorph (I.3.2), dimethomorph (I.3.3), buprofen (I.3.4), bensulfuron-methyl (I.3.5), propineb (I.3.6), valifenalate (I.3.7);

[0188] J) Plant defense inducers (P1 to P8)

[0189] -Aranoic acid benzene-S-methyl (J.1.1), thiabendazole (J.1.2), isothiazine (J.1.3), thiabendazole (J.1.4), cyclophosphamide-calcium (J.1.5); Phosphates: ethphosphonic acid (J.1.6), aluminum triethphosphonate (J.1.7), phosphorous acid and its salts (J.1.8), potassium bicarbonate or sodium bicarbonate (J.1.9), 4-cyclopropyl-N-(2,4-dimethoxyphenyl)thiadiazole-5-carboxamide (J.1.10), calcium phosphonate (J.1.11), potassium phosphonate (J.1.12), dichlorothiazide (J.1.13);

[0190] K) Mode of action unknown (U, unknown)

[0191] - Bronitrofurazone (K.1.1), Cycloflufenicol (K.1.3), Cymoxanil (K.1.4), Dato'a (K.1.5), Imazalil (K.1.6), Pyridaben (K.1.8), Wild Bean Blight (K.1.9), Wild Bean Blight-Methyl Sulfate (K.1.10), Diphenylamine (K.1.11), Seed Coating Ester (K.1.12), Flumetover (K.1.14), Flumetylsulforim (K.1.60), Sulfocarb (K.1.15), Fluthiazolinone (K.1.16), Hypersensitive Protein (K.1.17), Trichloromethylpyridine (K.1.19), Phthalosporin (K.1.19) .1.20), quinoline copper (K.1.22), seboctylamine (K.1.61), isobutylethoxyquinoline (K.1.24), chlorothalonil (K.1.25), azoxystrobin (K.1.26), N'-(4-(4-chloro-3-trifluoromethyl-phenoxy)-2,5-dimethyl-phenyl)-N-ethyl-N-methylformamidin (K.1.27), N'-(4-(4-fluoro-3-trifluoromethyl-phenoxy)-2,5-dimethyl-phenyl)-N-ethyl-N-methylformamidin (K.1.28), N'-[4-[[3-[(4-chlorophenyl)methyl]-1,2,4-thiadiazol-5-yl]oxy]-2 [5-Dimethyl-phenyl]-N-ethyl-N-methyl-formamidinium (K.1.29), N'-(5-bromo-6-indan-2-yloxy-2-methyl-3-pyridyl)-N-ethyl-N-methyl-formamidinium (K.1.30), N'-[5-bromo-6-[1-(3,5-difluorophenyl)ethoxy]-2-methyl-3-pyridyl]-N-ethyl-N-methyl-formamidinium (K.1.31), N'-[5-bromo-6-(4-isopropylcyclohexyloxy)-2-methyl-3-pyridyl]-N-ethyl-N-methyl-formamidinium (K.1.32), N'-[5-bromo-2-methyl-6-(1-phenylethoxy)-3-pyridyl]-N-ethyl -N-methylformamidin (K.1.33), N'-(2-methyl-5-trifluoromethyl-4-(3-trimethylsilyl-propoxy)phenyl)-N-ethyl-N-methylformamidin (K.1.34), N'-(5-difluoromethyl-2-methyl-4-(3-trimethylsilyl-propoxy)phenyl)-N-ethyl-N-methylformamidin (K.1.35), 2-(4-chloro-phenyl)-N-[4-(3,4-dimethoxy-phenyl)-isoxazol-5-yl]-2-prop-2-alkynyloxy-acetamide (K.1.36), 3-[5-(4-chloro-phenyl)-2,3-dimethyl-isoxazolidine-3-yl]-pyridine (pyridoxazole) (K.1.37), 3-[5-(4-methylphenyl)-2,3-dimethyl-isoxazolidine-3-yl]-pyridine (K.1.38), 5-chloro-1-(4,6-dimethoxy-pyrimidin-2-yl)-2-methyl-1H-benzimidazole (K.1.39), (Z)-3-amino-2-cyano-3-phenyl-prop-2-enoic acid ethyl ester (K.1.40), tetrazolium pyridine ester (K.1.41), N-[6-[[(Z)-[(1-methyltetrazole-5-yl)-phenyl-methylene] [amino]oxymethyl]-2-pyridyl]amyl carbamate (K. 1.42), N-[6-[[(Z)-[(1-methyltetrazol-5-yl)-phenyl-methylene]amino]oxymethyl]-2-pyridyl]but-3-kynyl carbamate (K. 1.43), thiamethoxam (K. 1.48), bromodiphenyl ether (K. 1.49), 2-(6-benzyl-2-pyridyl)quinazoline (K. 1.50), 2-[6-(3-fluoro-4-methoxy-phenyl)-5-methyl- [2-pyridyl]quinazoline (K. 1.51), N'-(2,5-dimethyl-4-phenoxy-phenyl)-N-ethyl-N-methyl-formamidin (K. 1.53), azoxystrobin (K. 1.54), N'-[5-bromo-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-ethyl-N-methyl-formamidin (K. 1.56), N'-[4-(4,5-dichlorothiazol-2-yl)oxy-2,5-dimethyl-phenyl]-N-ethyl -N-methylformamidin (K. 1.57), flufenoxadiazam (K. 1.58), [MoA Recommendation: Class II histone deacetylase inhibitor], N-methyl-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]thiobenzamide (K. 1.59), N-methoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]cyclopropaneformamide (K. 1.60; WO 2018 / 177894, WO 2020 / 212513), N-((4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl)methyl)propionamide (K.1.62), 3,3,3-trifluoro-N-[[3-fluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propionamide (K.1.63), 3,3,3-trifluoro-N-[[2-fluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propionamide (K.1.64), N-[2,3-difluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzyl]butyramide (K.1.65), N-[[2,3-difluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]-3,3,3-trifluoropropionamide (K.1.66), 1-methoxy-1-methyl-3-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea (K.1.67), 1,1-diethyl-3-[[4-[5-[trifluoromethyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea (K.1.68), N,2-dimethoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propionamide (K.1.69), N-ethyl 2-methyl-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propionamide (K. 1.70), 1-methoxy-3-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea (K. 1.71), 1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrrolidone-2-one (K. 1.72), 1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]piperidin-2-one (K. 1.73), 4-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]piperidin-2-one 3-yl]phenyl]methyl]morpholin-3-one (K. 1.74), 4,4-dimethyl-2-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]isoxazolidine-3-one (K. 1.75), 2-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]isoxazolidine-3-one (K. 1.76), 5,5-dimethyl-2-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]isoxazolidine-3-one (K. 1.77), 3,3-dimethyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl] [Methyl]piperidin-2-one (K. 1.78), 2-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]oxazin-3-one (K. 1.79), 1-[[3-fluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]azacycloheptane-2-one (K. 1.80), 4,4-dimethyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrrolidine-2-one (K. 1.81), 5-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrrolidine-2-one (K. 1.82), ethyl 1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrazole-4-carboxylate (K.1.83), N-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrazole-4-carboxamide (K.1.84), N,N-dimethyl-1-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzyl]-1H-1,2,4-triazol-3-amine (K.1.85), N-methoxy-N-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrazole-4-carboxamide (K.1.85) K.1.86), propyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrazole-4-carboxamide (K.1.87), N-methoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrazole-4-carboxamide (K.1.88), N-allyl-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propionamide (K.1.89), 3-ethyl-1-methoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea (K.1.90), 1,3- Dimethoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea (K. 1.91), N-allyl-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]acetamide (K. 1.92), N-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzyl]cyclopropaneformamide (K. 1.93), 1-methyl-3-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea (K. 1.94), N'-[2-chloro-4-(2-fluorophenoxy)-5-methyl-phenyl]-N-ethyl-N- Methyl-formamidinium (K. 1.95), N'-[2-chloro-4-[(4-methoxy-phenyl)methyl]-5-methyl-phenyl]-N-ethyl-N-methyl-formamidinium (K. 1.96), N'-[2-chloro-4-[(4-cyano-phenyl)methyl]-5-methyl-phenyl]-N-ethyl-N-methyl-formamidinium (K. 1.97), N'-[2,5-dimethyl-4-(o-tolylmethyl)phenyl]-N-ethyl-N-methyl-formamidinium (K. 1.98), 6-chloro-3-(3-cyclopropyl-2-fluoro-phenoxy)-N-[2-(2,4-dimethylphenyl)-2,2-difluoro-ethyl]-5-methyl-pyridazine-4-carboxamide (K. 1.95).99), 3-(3-bromo-2-fluoro-phenoxy)-6-chloro-N-[2-(2-chloro-4-methyl-phenyl)-2,2-difluoro-ethyl]-5-methyl-pyridazine-4-carboxamide (K.1.100), 6-chloro-N-[2-(2-chloro-4-methyl-phenyl)-2,2-difluoro-ethyl]-3-(3-cyclopropyl-2-fluoro-phenoxy)-5-methyl-pyridazine-4-carboxamide (K.1.101), 6-chloro-3-(3-cyclopropyl-2-fluoro-phenoxy)-N-[2-(3,4-dimethyl-phenyl)-[2-(3,4-difluoro ... [2-(2,4-dimethylphenyl)-2,2-difluoroethyl]-5-methylpyridazin-4-carboxamide (K.1.102), 6-chloro-3-(3-chloro-2-fluoro-phenoxy)-N-[2-(2,4-dimethylphenyl)-2,2-difluoroethyl]-5-methylpyridazin-4-carboxamide (K.1.103), N-[2-(2-bromo-4-methylphenyl)-2,2-difluoroethyl]-6-chloro-3-(3-cyclopropyl-2-fluoro-phenoxy)-5-methylpyridazin-4-carboxamide (K.1.104);

[0192] L) Biological pest control agents

[0193] L1) Microbial agents with antifungal, antibacterial, antiviral, and / or plant defense activator activities: Powdery mildew parasiticus, Aspergillus flavus, Bacillus buddingus, Bacillus hygroscopicus, Bacillus amyloliquefaciens, Bacillus amyloliquefaciens subsp. plantarum (also known as Bacillus bellelesi), Bacillus megaterium, Bacillus mohaiweiii, Bacillus mycosis fungiformis, Bacillus pumilus, Bacillus simplex, Bacillus halophyte, Bacillus subtilis, Bacillus amyloliquefaciens var. subtilisi, Bacillus bellelesi, Candida oligosacchari, Candida saitoana, Clavibactermegia ichiganensis (bacteriophage), Shield mold, Cryptococcus parasiticus, Cryptococcus albus, Dilophosphora alopecuri, Fusarium oxysporum, Clonecrophys rosea f. catenulate (also known as Gliocladium) (catenulatum), pink bromoxynil, antibiotic lysinophil, mycolytic bromoxynil, drupocytosaccharomyces, microdochium dimerum, microsporum, Muscodor albus, Bacillus vesicularis, epiphytic Bacillus, polymyxa, pantothecin, Penicillium barometz, *Pseudomonas* species, *Pseudomonas leucosus*, *Pseudozyma flocculosa*, *Pichia aberrant*, *Pythium oligandrum*, *Sphaerodes mycoparasitica*, *Streptomyces glaucum*, *Streptomyces lidiflorus*, *Streptomyces purpureus*, *Trichoderma asperelloides*, *Trichoderma spp.*, *Trichoderma pellucida*, *Trichoderma galbana*, *T. harmatum*, *Trichoderma harzianum*, *T. polysporum*, *T. streptococcus*. stromaticum), Trichoderma virens, Trichoderma viride, Typhula phacorrhiza, Odman's sclerotium, Verticillium dahliae, and small zucchini yellow mosaic virus (non-toxic strain).

[0194] L2) Biochemical pest control agents with antifungal, antibacterial, antiviral and / or plant defense activator activities: hypersensitive protein, Polygonum cuspidatum extract;

[0195] L3) Microbial biocides with insecticidal, acaricidal, snail-killing, and / or nematicidal activity: *Agrobacterium radiata*, *Bacillus cereus*, *Bacillus stolonifer*, *Bacillus thuringiensis*, *Bacillus thuringiensis* subsp. *catella*, *Bacillus thuringiensis* subsp. *israelica*, *Bacillus thuringiensis* subsp. *wax moth*, *Bacillus thuringiensis* subsp. *kulstaq*, *Bacillus thuringiensis* subsp. *tenacylpyridae*, *Beauveria bassiana*, *Beauveria bassiana* species, *Burkholderia* species, and active purple bacteria (Chromobacterium). subtsugae), codling moth granulovirus (CpGV), pseudocodling moth granulovirus (CrleGV), species of Flavobacterium, bollworm nucleopolyhedrovirus (HearNPV), corn noctuid moth nucleopolyhedrovirus (HzNPV), corn noctuid moth monochroic nucleopolyhedrovirus (HzSNPV), *Heterobacter hygrophila*, *Cladosporium flavum*, *Lecanicillium longisporum*, *L. muscarium*, *Metarhizium anisopliae*, *Metarhizium anisopliae* microsporum variant, *Metarhizium anisopliae* locust variant, *Nomura leishii*, *Paecilomyces flavum*, *Paecilomyces lilacinus*, *Bacillus japonicus*, *Bacillus pastoris* species, *Paecilomyces szawa*, *Paecilomyces punctata*, *P. ramosa*, *P. thornea*, *P. ouss*. usgae), fluorescent pseudomonas, gray noctuid moth nucleopolyhedrovirus (SpliNPV), small leafroller nematode, small noctuid moth nematode, sawfly nematode, fresh yellow streptomyces, fine yellow streptomyces;

[0196] L4) Biochemical pest control agents with insecticidal, acaricidal, snail-killing, pheromone-based, and / or nematicidal activities: L-carvone, citral, (E,Z)-7,9-dodecadien-1-yl acetate, ethyl formate, (E,Z)-2,4-decadienoic acid ethyl ester (pear ester), (Z,Z,E)-7,11,13-hexadecanetrienal, heptyl butyrate, isopropyl myristate, lavender ester, cis-jasmone, 2-methyl-1-butanol, methyl eugenol, methyl jasmone, (E,Z)-2,13-octadecadien-1-ol, acetic acid (E,Z) -2,13-octadecadien-1-ol ester, (E,Z)-3,13-octadecadien-1-ol, (R)-1-octen-3-ol, termite pheromone, (E,Z,Z)-3,8,11-tetradecadienyl acetate, (Z,E)-9,12-tetradecadien-1-yl acetate, (Z)-7-tetradecen-2-one, (Z)-9-tetradecen-1-yl acetate, (Z)-11-tetradecenal, (Z)-11-tetradecen-1-ol, Chenopodium ambrosiodes extract, neem oil, Quilay extract;

[0197] L5) Microbial pest control agents with plant stress reduction, plant growth regulator, plant growth promotion and / or yield increase activities: Azotobacter agalactiae, Azotobacter brasiliensis, Azotobacter lipophila, Azotobacter iridozoensis, Azotobacter high-salt, Slow-growing rhizobia species, Slow-growing rhizobia ehrlich, Slow-growing rhizobia soybean, Slow-growing rhizobia lizardii, Slow-growing lupin rhizobia, Delfordia acidophila, Arbuscular mycorrhizal fungi, Mesophytic rhizobia species, Rhizobia pea biotype, Rhizobia pea clover biotype, Rhizobia pea broad bean biotype, Rhizobia tropicalis and Rhizobia spp. alfalfa;

[0198] O) Insecticides from categories O.1 to O.29

[0199] 0.1 Acetylcholinesterase (AChE) inhibitors: Aldicarb, fenvalerate, carbofuran, methylcarbate, methylcarbate, carbaryl, carbamate, carbofuran, methylcarbate, ethylcarbate, methylcarbate, imidacloprid, furazolidone, isoprocarb, imidacloprid, methomyl, fenvalerate, chlorpyrifos, propoxur, thiamethoxam, thiophanate-methyl, methylcarbate, XMC, imidacloprid, pymetrozine; Phosphate, methylpyridinium, ethyl phosphonate, phosmet, thiophanate-methyl, phosmet, chlorpyrifos, chlorpyrifos, methyl chlorpyrifos, phosmet, pyridaben, phosmet-S-methyl, diazinon, dichlorvos / DDVP, phosmet, dimethoate, methyl imidacloprid, ethylcarbate Phosphorus, EPN, ethion, propargite, phosmet, benzylphos, fenitrothion, fenthion, thiamethoxam, heptamethrin, cypermethrin, isopropylamine, O-(methoxyaminothio-phosphoryl)salicylic acid isopropyl ester, isoxazolium, malathion, phosmet, methamidophos, chlorpyrifos, phosmet, dibromophos, omethoate, sulfonium phosphate, parathion, methyl parathion, phosmet, phosmet, phosmet, phosmet, phosmet, phosmet, phosmet, phosmet, phosmet, phosmet, phosmet, phosmet, phosmet, phosmet, phosmet, phosmet, phosmet, pyrazophos, pyridazine, quinalphos, phosmet, phosmet, butylpyrimidine, dithion, terbufos, chlorpyrifos, methyl ethion, triazophos, trichlorfon, phosmet.

[0200] O.2 GABA-gated chloride channel antagonists: endosulfan, chlordane; acetamiprid, fipronil, butenpyram, pyrafluprole, pyriprole.

[0201] O.3 Sodium channel modulators: Flufenoxuron, Allethrin, Dextrorotatory-cis-trans Allethrin, Dextrorotatory-trans Allethrin, Bifenthrin, K-Bifenthrin, Bioallethrin, Bioallethrin S-cyclopentenyl, Biobenzylfuran, Cypermethrin, Cypermethrin, β-Cypermethrin, Trifluralin, λ-Cypermethrin, γ-Cypermethrin, Cypermethrin, α-Cypermethrin, β-Cypermethrin, θ-Cypermethrin, ζ-Cypermethrin, Lambda-cypermethrin, Delanolyl, Enyne Pyrethroids, cypermethrin, deltamethrin, cypermethrin, cypermethrin, flufenoxuron, cypermethrin, t-flumethrin, bromoflumethrin, heptamethrin, imidacloprid, chlorflumethrin, methoxyfenozide, methoxyfenozide, ε-methoxyfenozide, permethrin, fenfluroxyfenozide, ethylanthrin, propargite, pyrethroids (pyrethrum), pyrethrum, flusilazole, heptamethrin, κ-heptamethrin, tetrafluoroethylene, pyrethroids, tetrabromopyrethrin, tetrafluoroethylene; DDT, methoxydichlorophenoxyacetic acid (DDT);

[0202] O.4 Nicotinic acetylcholine receptor (nAChR) agonists: acetamiprid, thiamethoxam, cyclopyridamole, dinotefuran, imidacloprid, acetamiprid, thiamethoxam; 4,5-dihydro-N-nitro-1-(2-epoxyethylenemethyl)-1H-imidazol-2-amine, (2E)-1-[(6-chloropyridin-3-yl)methyl]-N'-nitro-2-pentylaminoguanidine; 1-[(6-chloropyridin-3-yl)methyl]-7-methyl-8-nitro-5-propoxy-1,2,3,5,6,7-hexahydroimidazo[1,2-a]pyridine; nicotine; flupyridine, flupyrflufenone, trifluralin, dithiazolinone, flupyridine;

[0203] 0.5 Nicotinic acetylcholine receptor allosteric activators: spinosad, ethyl spinosad;

[0204] 0.6 Chloride channel activators: abamectin, emamectin benzoate, ivermectin, rapamycin, mibamectin;

[0205] O.7 Juvenile hormone mimics: acetamiprid, acetamiprid, acetamiprid; phenoxycarb, fenvalerate;

[0206] O.8 Various non-specific (multi-site) inhibitors: methyl bromide and other alkyl halides; trichloronitromethane, sulfonyl fluoride, borax, tartaric acid;

[0207] O.9 Regulators of TRPV channels in string organs: Biprofen, Pymetrozine, Flufenoxuron;

[0208] O.10 Mite growth inhibitors: Tetradifon, Thiamethoxam, Fludex; Etoxazole;

[0209] O.11 Microbial disruptors of the intestinal membrane in insects: Bacillus thuringiensis, Bacillus sphaericus, and their insecticidal proteins: Bacillus thuringiensis subsp. israelensis, Bacillus sphaericus, Bacillus thuringiensis subsp. aizawai, Bacillus thuringiensis subsp. kurstaki, Bacillus thuringiensis subsp. tenebrionis; Bt crop proteins: Cry1Ab, Cry1Ac, Cry1Fa, Cry2Ab, mCry3A, Cry3Ab, Cry3Bb, Cry34 / 35Ab1;

[0210] O.12 Mitochondrial ATP synthase inhibitors: butyl ether urea; triazole tin, tricyclic tin, phenylbutyl tin, chlorfenapyr, trichlorfon;

[0211] O.13 Oxidative phosphorylation decoupling agents via proton gradient interference: brofentanil, DNOC, fipronil;

[0212] O.14 Nicotinic acetylcholine receptor (nAChR) channel blockers: chlorpyrifos, fenitrothion, chlorpyrifos, dichlorvos;

[0213] O.15 Chitosan biosynthesis inhibitors type 0: bis(triflufenoxuron), flufenoxuron, diflufenoxuron, flucyclourea, flufenoxuron, flufenoxuron, lufenuron, flufenoxuron, polyfluorourea, flubendiamide, chlorfenapyr;

[0214] O.16 Chitosan biosynthesis inhibitor type 1: thiamethoxam;

[0215] O.17 Ecdyskin disruptor: cyromazine;

[0216] O.18 Ecdysone receptor agonists: methoxyfenozide, fenbufenozide, chlorfenapyr, furazolidone, cyclotebufenozide;

[0217] O.19 Octopus amine receptor agonist: Dimethicone;

[0218] O.20 Inhibitors of electron transport in mitochondrial complex III: flufenoxuron, cypermethrin, pyrimethanil, bifenazate;

[0219] O.21 Inhibitors of electron transport in mitochondrial complex I: quinclorac, azoxystrobin, pyrimethanil, pyridaben, pyridabenamide; rotenone;

[0220] O.22 Voltage-dependent sodium channel blockers: indoxacarb, cyfluthrin, 2-[2-(4-cyanophenyl)-1-[3-(trifluoromethyl)phenyl]ethylene]-N-[4-(difluoromethoxy)phenyl]-hydrazinoamide, N-(3-chloro-2-methylphenyl)-2-[(4-chlorophenyl)[4-[methyl(methylsulfonyl)amino]phenyl]ethylene]-hydrazinoamide, N-[4-chloro-2-[[(1,1-dimethylethyl)amino]carbonyl]-6-methylphenyl]-1-(3-chloro-2-pyridyl)-3-(fluoromethoxy)-1H-pyrazole-5-carboxamide, 2-[2-(4-cyanophenyl)-1-[3-(trifluoromethyl)phenyl]ethylene]-N-[4-(difluoromethoxy)phenyl]-hydrazinoamide;

[0221] O.23 Acetyl-CoA carboxylase inhibitors: Spirodiclofen, Spirodiclofen, Spirodiclofen ethyl ester, Methoxypiperidine ethyl ester, Spirodiclofen diester, 11-(4-chloro-2,6-dimethylphenyl)-12-hydroxy-1,4-dioxa-9-azabispirol[4.2.4.2]tetradecano-11-en-10-one, and spirochete;

[0222] O.24 Inhibitors of electron transport in mitochondrial complex IV: aluminum phosphide, calcium phosphide, phosphine, zinc phosphide, cyanide;

[0223] 0.25 Mitochondrial complex II electron transport inhibitors: pyridaben, fenflurfen, etoxazole, pyrazolyl aniline;

[0224] 0.28 Rianotinamide receptor modulators: chlorantraniliprole, bromocyanamide, cyclobromocyanamide, flubendiamide, fluchlorfenapyr, (R)-3-chloro-N 1 -{2-Methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl}-N 2 -(1-Methyl-2-methylsulfonylethyl)phthalamide, (S)-3-chloro-N 1 -{2-Methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl}-N 2-(1-Methyl-2-methylsulfonylethyl)phthalamide, methyl-2-[3,5-dibromo-2-({[3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-yl]carbonyl}amino)benzoyl]-1,2-dimethylhydrazine carbamate; N-[4,6-dichloro-2-[(diethyl-λ-4-thionyl)carbamoyl]phenyl]-2-(3-chloro-2-pyridinyl)-5-(trifluoromethyl)pyrazole-3-carboxamide; N-[4-chloro-2-[(diethyl-λ-4-thionyl)carbamoyl]-6-methyl-phenyl]-2-(3-chloro-2-pyridinyl)-5-(trifluoromethyl)pyrazole-3-carboxamide; N-[2-(5-amino-1,3,4-thiadiazol-2-yl)-4-chloro-6-methyl] [Phenyl]-3-bromo-1-(3-chloro-2-pyridyl)-1H-pyrazole-5-carboxamide; 3-chloro-1-(3-chloro-2-pyridyl)-N-[2,4-dichloro-6-[[(1-cyano-1-methylethyl)amino]carbonyl]phenyl]-1H-pyrazole-5-carboxamide; tetrachlorfenapyr; tetrazolium fenvalerate; thiofenoxam; N-[4-chloro-2-[[(1,1-dimethylethyl)amino]carbonyl]-6-methylphenyl]-1-(3-chloro-2-pyridyl)-3-(fluoromethoxy)-1H-pyrazole-5-carboxamide; chlorfenapyr; N-[2-(5-amino-1,3,4-thiadiazol-2-yl)-4-chloro-6-methylphenyl]-3-bromo-1-(3-chloro-2-pyridyl)-1H-pyrazole-5-carboxamide;

[0225] O.29 String organ modulator: flupyradifurone;

[0226] 0.30 GABA-gated chloride channel allosteric modulators: brofenoxam, chlorfenapyr, isoxazolidinamide;

[0227] O.33 Calcium-activated potassium channel regulator: Flufenoxuron (acynonapyr);

[0228] O.34 Flumetoquin, an inhibitor of electron transport in mitochondrial complex III at the Qi site.

[0229] Insecticidal compounds with unknown or uncertain modes of action (O.UN): Afurazone, Azadirachtin, Sulfamethrin, Benzoate, Bromopropylate, Acaricide, Cryolite, Cyproflanilid, Dichloropyrimipyrimidine, Trichlorfon, Pyrimethanil, Pyrimethanil, Flometoquin, Fluthiamethoxam, Fluhexafon, Flupyradifon, Flureranil, Methaldehyde, Oxadiazon, Synergist, Acetaminophen, Tioxazafen, Trifluenfuronate, Umifoxolaner, 11-(4-chloro-2,6-dimethylphenyl)-12- Hydroxy-1,4-dioxa-9-azabispiro[4.2.4.2]-tetradecano-11-en-10-one, 3-(4'-fluoro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-oxa-1-azaspiro[4.5]decano-3-en-2-one, 4-cyano-N-[2-cyano-5-[[[2,6-dibromo-4-[1,2,2,3,3,3-hexafluoro-1-(trifluoromethyl)propyl]phenyl]amino]carbonyl]phenyl]-2-methyl-benzamide, 4-cyano-3-[(4-cyano-2-methyl-benzoyl)amino]-N-[2,6-dichloro-4-[1,2,2,3,3,3-hexafluoro-1-(trifluoromethyl)propyl]phenyl]-2-fluoro- Benzamide, N-[5-[[[2-chloro-6-cyano-4-[1,2,2,3,3,3-hexafluoro-1-(trifluoromethyl)propyl]phenyl]amino]carbonyl]-2-cyano-phenyl]-4-cyano-2-methyl-benzamide, N-[5-[[[2-bromo-6-chloro-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]carbonyl]-2-cyano-phenyl]-4-cyano-2-methyl-benzamide, N-[5-[[[2-bromo-6-chloro-4-[1,2,2,3,3,3-hexafluoro-1-(trifluoromethyl)propyl]phenyl]amino]carbonyl]-2-cyano-phenyl]-4-cyano-2-methyl-benzamide, 4- Cyano-N-[2-cyano-5-[[[2,6-dichloro-4-[1,2,2,3,3,3-hexafluoro-1-(trifluoromethyl)propyl]phenyl]amino]carbonyl]phenyl]-2-methyl-benzamide, 1-[2-fluoro-4-methyl-5-[(2,2,2-trifluoroethyl)sulfinyl]phenyl]-3-(trifluoromethyl)-1H-1,2,4-tetrazol-5-amine, N-[5-[[[2-bromo-6-chloro-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]amino]carbonyl]-2-cyano-phenyl]-4-cyano-2-methyl-benzamide, 4-cyano-N-[2-cyano-5-[[[2,6-dichloro-4-[1,2,2,3,3,3-hexafluoro-1-(trifluoromethyl)propyl]phenyl]amino]carbonyl]-2-cyano-phenyl]-4-cyano-2-methyl-benzamide,2-Tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]amino]carbonyl]phenyl]-2-methyl-benzamide, active material based on Bacillus stolonifer (Votivo, I-1582); trifluoroimidazamide; 5-[3-[2,6-dichloro-4-(3,3-dichloroallyloxy)phenoxy]propoxy]-1H-pyrazole; N-[5-[[2-bromo-6-chloro-4-[1,2,2,3,3,3-hexafluoro-1-(trifluoromethyl)-propyl]phenyl]carbamoyl]-2-cyano-phenyl]-4-cyano-2-methyl-benzamide; 4-cyano-N-[2-cyano-5-[[2,6-dichloro-4-[1,2,2,3,3,3-hexafluoro-1-(trifluoromethyl)-propyl]] [Phenyl]carbamoyl]phenyl]-2-methyl-benzamide; 4-cyano-N-[2-cyano-5-[[2,6-dichloro-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]carbamoyl]phenyl]-2-methyl-benzamide; N-[5-[[2-bromo-6-chloro-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]carbamoyl]-2-cyano-phenyl]-4-cyano-2-methyl-benzamide; 2-(1,3-dioxane-2-yl)-6-[2-(3-pyridyl)-5-thiazolyl]-pyridine; 2-[6-[2-(5-fluoro-3-pyridyl)-5-thiazolyl]-2-pyridyl]pyrimidine; 2-[6- [2-(3-pyridinyl)-5-thiazolyl]-2-pyridinyl]pyrimidine; N-methylsulfonyl-6-[2-(3-pyridinyl)thiazolyl-5-yl]pyridine-2-carboxamide; N-methylsulfonyl-6-[2-(3-pyridinyl)thiazolyl-5-yl]pyridine-2-carboxamide; 1-[(6-chloro-3-pyridinyl)methyl]-1,2,3,5,6,7-hexahydro-5-methoxy-7-methyl-8-nitro-imidazo[1,2-a]pyridine; 1-[(6-chloropyridinyl-3-yl)methyl]-7-methyl-8-nitro-1,2,3,5,6,7-hexahydroimidazo[1,2-a]pyridine-5-ol; N-(3-chloro-2-methylphenyl)-2-[(4-chlorophenyl)[4-[ [Methyl(methylsulfonyl)amino]phenyl]methylene]-hydrazine carboxamide; 1-[(6-chloro-3-pyridyl)methyl]-1,2,3,5,6,7-hexahydro-5-methoxy-7-methyl-8-nitro-imidazo[1,2-a]pyridine; 2-(3-pyridyl)-N-(2-pyrimidinylmethyl)-2H-indazole-5-carboxamide; chlorpyrifos; saloranar, loteranar; N-[4-chloro-3-[[(phenylmethyl)amino]carbonyl]phenyl]-1-methyl-3-(1,1,2,2,2-pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide; N-[4-chloro-3-[[(phenylmethyl)amino]carbonyl]phenyl]-1-methyl-3-(1,1,2,2,2-pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;2,2-Pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide; 2-(3-ethylsulfonyl-2-pyridyl)-3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridine, 2-[3-ethylsulfonyl-5-(trifluoromethyl)-2-pyridyl]-3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridine; N-[4-chloro-3-(cyclopropylcarbamoyl)phenyl]-2-methyl-5-(1,1,2,2,2-pentafluoroethyl)-4-(trifluoromethyl)pyrazole-3-carboxamide, N-[4-chloro-3-[(1-cyanocyclopropyl)carbamoyl]phenyl]-2-methyl-5-(1,1,2,2,2-pentafluoroethyl)- 4-(trifluoromethyl)pyrazole-3-carboxamide; benzpyrimoxan; tigolaner; oxazolylsulfadiazine; [(2S,3R,4R,5S,6S)-3,5-dimethoxy-6-methyl-4-propoxy-tetrahydropyran-2-yl]-N-[4-[1-[4-(trifluoromethoxy)phenyl]-1,2,4-triazol-3-yl]phenyl]carbamate; [(2S,3R,4R,5S,6S)-3,4,5-trimethoxy-6-methyl-tetrahydropyran-2-yl]N-[4-[1-[4-(trifluoromethoxy)phenyl]-1,2,4-triazol-3-yl]phenyl]carbamate; [(2S,3R,4R,5S,6S)-3,4,5-trimethoxy-6-methyl-tetrahydropyran-2-yl]N-[4-[1-[4-(trifluoromethoxy)phenyl]-1,2,4-triazol-3-yl]phenyl]carbamate; [(2S,3 R,4R,5S,6S)-3,5-dimethoxy-6-methyl-4-propoxy-tetrahydropyran-2-yl]-N-[4-[1-[4-(1,1,2,2,2-pentafluoroethoxy)phenyl]-1,2,4-triazol-3-yl]phenyl]carbamate; [(2S,3R,4R,5S,6S)-3,4,5-trimethoxy-6-methyl-tetrahydropyran-2-yl]-N-[4-[1-[4-(1,1,2,2,2-pentafluoroethoxy)phenyl]-1,2,4-triazol-3-yl]phenyl]carbamate; (2Z)-3-(2-isopropylphenyl)-2-[(E)-[4-[1-[4-(trifluoromethoxy)phenyl]-1,2,4-triazol-3-yl]phenyl]carbamate [Azol-3-yl]phenyl]methylenehydrazinyl]thiazolidin-4-one, (2Z)-3-(2-isopropylphenyl)-2-[(E)-[4-[1-[4-(1,1,2,2,2-pentafluoroethoxy)phenyl]-1,2,4-triazol-3-yl]phenyl]methylenehydrazinyl]thiazolidin-4-one, (2Z)-3-(2-isopropylphenyl)-2-[(E)-[4-[1-[4-(1,1,2,2,2-pentafluoroethoxy)phenyl]-1,2,4-triazol-3-yl]phenyl]methylenehydrazinyl]thiazolidin-4-one; 2-(6-chloro-3-ethylsulfonyl-imidazo[1,2-a]pyridin-2-yl)-3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridine, 2-(6-bromo-3-ethylsulfonyl-imidazo[1,2-a]pyridin-2-yl)-3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridine, 2-(3-ethylsulfonyl-6-iodo-imidazo[1,2-a]pyridin-2-yl)-3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridine, 2-(7-chloro-3-ethylsulfonyl-imidazo[1,2-a]pyridin-2-yl)-3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridine, 2-(7-chloro-3-ethylsulfonyl-imidazo[1,2-a]pyridin-2-yl)-3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridine Pyridine, 2-(3-ethylsulfonyl-7-iodo-imidazo[1,2-a]pyridin-2-yl)-3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridine, 3-ethylsulfonyl-6-iodo-2-[3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridin-2-yl]imidazo[1,2-a]pyridin-8-carboxynitrile, 2-[3-ethylsulfonyl-8-fluoro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]-3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridine, 2-[3-ethylsulfonyl-7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]-3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridine 2-[3-ethylsulfonyl-7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]-3-methyl-6-(trifluoromethyl)imidazo[4,5-c]pyridine, 2-(6-bromo-3-ethylsulfonyl-imidazo[1,2-a]pyridin-2-yl)-6-(trifluoromethyl)pyrazolo[4,3-c]pyridine; N-[[2-fluoro-4-[(2S,3S)-2-hydroxy-3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidine-1-yl]phenyl]methyl]cyclopropaneformamide; 2-[2-fluoro-4-methyl-5-(2,2,2-trifluoroethylsulfinyl)phenyl]imino-3- (2,2,2-trifluoroethyl)thiazolidin-4-one; flupentixol, N-[3-chloro-1-(3-pyridinyl)pyrazol-4-yl]-2-methylsulfonyl-propionamide, trifluoropyridineamine; N-[4-chloro-3-[(1-cyanocyclopropyl)carbamoyl]phenyl]-2-methyl-4-methylsulfonyl-5-(1,1,2,2,2-pentafluoroethyl)pyrazol-3-carboxamide, cyclopropionamide, cyclopropionamide; 1,4-dimethyl-2-[2-(pyridin-3-yl)-2H-indazol-5-yl]-1,2,4-triazolidine-3,5-dione, 2-[2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthioalkyl)phenyl]imino-3-(2,2,2-Trifluoroethyl)thiazolidin-4-one, indazole, N-[4-chloro-2-(3-pyridyl)thiazolidin-5-yl]-N-ethyl-3-methylsulfonyl-propionamide, N-cyclopropyl-5-[(5S)-5-(3,5-dichloro-4-fluoro-phenyl)-5-(trifluoromethyl)-4H-isooxazol-3-yl]isoquinoline-8-carboxamide, 5-[(5S)-5-(3,5-dichloro-4-fluoro-phenyl)-5-(trifluoromethyl)-4H-isooxazol-3-yl]-N-(pyrimidin-2-ylmethyl)isoquinoline-8-carboxamide, N-[1-(2,6-difluorophenyl)pyrazol-3-yl]- 2-(trifluoromethyl)benzamide, 5-((1R,3R)-3-(3,5-bis(trifluoromethyl)phenyl)-2,2-dichlorocyclopropane-1-carbamate)-2-chloro-N-(3-(2,2-difluoroacetamido)-2,4-difluorophenyl)benzamide, 1-[6-(2,2-difluoro-7-methyl-[1,3]dioxane[4,5-f]benzimidazole-6-yl)-5-ethylsulfonyl-3-pyridyl]cyclopropanecarboxynitrile, 6-(5-cyclopropyl-3-ethylsulfonyl-2-pyridyl)-2,2-difluoro-7-methyl-[1,3]dioxane[4,5-f]benzimidazole.

[0230] At least one active compound III in component 3) is different from at least one active compound II in component 2).

[0231] The present invention also relates to a method for controlling plant pathogenic fungi using the above-mentioned ternary mixtures; to an agricultural chemical composition comprising these ternary mixtures; and to an agricultural chemical composition further comprising seeds containing these mixtures.

[0232] The preparation of the active substances referred to as compounds II or III and their activities, for example, against harmful fungi are known (see: http: / / www.alanwood.net / pesticides / ); these substances are commercially available. For compounds described by IUPAC nomenclature, their preparation and their phytotoxic activity are also known (see Can. J. Plant Sci. 48(6), 587-94, 1968; EP-A 141 317; EP-A 152 031; EP-A 226 917; EP-A 243 970; EP-A 256 503; EP-A 428 941; EP-A 532 022; EP-A 1 028 125; EP-A 1 035122; EP-A 1 201 648; EP-A 1 122 244, JP 2002316902; DE 19650197; DE 10021412; DE102005009458; US WO 00 / 29404; WO 00 / 46148; WO 00 / 65913; WO 01 / 54501; WO 01 / 56358; WO 02 / 22583; WO 02 / 40431; WO 03 / 10149; WO 03 / 11853; WO 03 / 14103; WO 03 / 16286; WO 03 / 53145; WO 03 / 61388; WO 03 / 66609; WO 03 / 74491;WO 04 / 49804;WO 04 / 83193; WO 05 / 120234; WO 05 / 123689; WO 05 / 123690; WO 05 / 63721; WO 05 / 87772; WO 05 / 87773; WO 06 / 15866; WO 06 / 87325; WO 06 / 87343; WO 07 / 82098; WO 07 / 90624, WO 10 / 139271, WO 11 / 028657, WO 12 / 168188, WO 07 / 006670, WO 11 / 77514;WO 13 / 047749, WO 10 / 069882, WO 13 / 047441, WO 03 / 16303, WO 09 / 90181, WO 13 / 007767, WO 13 / 010862, WO 13 / 127704, WO 13 / 024009, WO 13 / 24010, WO 13 / 047441, WO 13 / 162072, WO 13 / 092224, WO 11 / 135833, CN1907024, CN 1456054, CN 103387541, CN 1309897, WO 12 / 84812, CN 1907024,WO09094442,WO 14 / 60177, WO 13 / 116251, WO 08 / 013622, WO 15 / 65922, WO 94 / 01546, EP2865265, WO 07 / 129454, WO 12 / 165511, WO 11 / 081174, WO 13 / 47441). ;

[0233] Preferably, these ternary mixtures contain a fungicidal compound as compound III, which are independently selected from groups A), B), C), D), E), F), G), H), I), J), K), and O).

[0234] Also preferred are ternary mixtures based on the binary mixtures disclosed herein, comprising at least one active compound as an additional component 3), wherein the at least one active compound is selected from the complex II inhibitors of group A), and more preferably from compounds (A.1.1), (A.1.4), (A.1.8), (A.1.10), (A.1.11), (A.1.12), (A.1.14), (A.1.17), (A.1.19), (A.1.25), (A.1.34), and (A.1.35). and (A.1.35); in particular selected from (A.1.1), (A.1.4), (A.1.8), (A.1.9), (A.1.13), (A.1.14), (A.1.17), (A. 1.24), (A.1.25), (A.1.26), (A.1.27), (A.1.30), (A.1.31), (A.1.32), (A.1.34), (A.1.35) and (A.1.38).

[0235] Also preferred are ternary mixtures based on the binary mixtures disclosed herein, comprising at least one active compound selected from group A) as an additional component 3), wherein the at least one active compound is selected from group A) in Q. oThe inhibitor of complex III at the site is more preferably selected from compounds (A.1.1), (A.1.4), (A.1.8), (A.1.9), (A.1.10), (A.1.11), (A.1.12), (A.1.14), (A.1.16), (A.1.17), (A.1.19), (A.1.25), (A.1.34), (A.1.35), and (A.1.38).

[0236] Also preferred are ternary mixtures based on the binary mixtures disclosed herein, comprising at least one active compound selected from group A) as an additional component 3), wherein the at least one active compound is selected from group A) in Q. i The inhibitor of complex III at the site is more preferably selected from compounds (A.2.1), (A.2.3), (A.2.4) and (A.2.5); particularly selected from (A.2.3), (A.2.4) and (A.2.5). (A.2.6).

[0237] Also preferred are ternary mixtures based on binary mixtures disclosed herein, comprising at least one active compound as an additional component 3), wherein the at least one active compound is selected from complex II inhibitors of group A), and more preferably from compounds (A.3.2), (A.3.3), (A.3.4), (A.3.7), (A.3.8), (A.3.9), (A.3.10), (A.3.11), (A.3.12), (A.3.15), (A.3.16), (A.3.17), (A.3.19), (A.3.21), (A.3.22), (A.3.23), (A.3.28), (A.3.29), and (A.3.31).

[0238] Also preferred is a ternary mixture based on the binary mixture disclosed herein, comprising at least one active compound as an additional component 3), wherein the at least one active compound is selected from other respiratory inhibitors of group A), more preferably from compounds (A.4.5) and (A.4.7).

[0239] Also preferred are ternary mixtures based on the binary mixtures disclosed herein, comprising at least one active compound as an additional component 3), wherein the at least one active compound is selected from C14 demethylase inhibitors of group B), and more preferably from compounds (B.1.4), (B.1.5), (B.1.8), (B.1.10), (B.1.12), (B.1.15), (B.1.17), (B.1.18), (B.1.21), (B.1.22), (B.1.23), (B.1.25), (B.1.26), (B.1.29), (B.1.38), (B.1.44), and (B.1.46).

[0240] Also preferred is a ternary mixture based on the binary mixture disclosed herein, comprising at least one active compound as an additional component 3), wherein the at least one active compound is selected from δ14-reductase inhibitors of group B), more preferably (B.2.4).

[0241] Also preferred is a ternary mixture based on the binary mixture disclosed herein, comprising at least one active compound as an additional component 3), wherein the at least one active compound is selected from 3-keto reductase inhibitors of group B), more preferably (B.3.1).

[0242] Also preferred are ternary mixtures based on binary mixtures disclosed herein, comprising at least one active compound as an additional component 3), wherein the at least one active compound is selected from phenylamides and acyl amino acid fungicides of group C), more preferably selected from compounds (C.1.4), (C.1.5) and (C.2.1); particularly (C.2.1).

[0243] Also preferred is a ternary mixture based on the binary mixture disclosed herein, comprising at least one active compound as an additional component 3), wherein the at least one active compound is selected from group D), more preferably from compounds (D.1.4), (D.1.5), (D.2.3), (D.2.5) and (D.2.6).

[0244] Also preferred is a ternary mixture based on the binary mixture disclosed herein, comprising at least one active compound as an additional component 3), wherein the at least one active compound is selected from group E), more preferably from compounds (E.1.1), (E.1.3), (E.2.2) and (E.2.3).

[0245] Also preferred are ternary mixtures based on binary mixtures disclosed herein, which include at least one active compound as an additional component 3), the at least one active compound being selected from group F), more preferably from compounds (F.1.2), (F.1.3) and (F.1.5).

[0246] Also preferred are ternary mixtures based on binary mixtures disclosed herein, which include at least one active compound as an additional component 3), the at least one active compound being selected from group G), more preferably from compounds (G.1.4), (G.3.1) and (G.5.1).

[0247] Also preferred are ternary mixtures based on the binary mixtures disclosed herein, comprising at least one active compound as an additional component 3), wherein the at least one active compound is selected from group H), more preferably from compounds (H.1.2), (H.1.4), (H.1.5), (H.1.6), (H.1.7), (H.2.2), (H.2.3), (H.2.5), (H.2.7), (H.3.2), (H.3.4), (H.3.5), (H.3.10), (H.4.2), (H.4.9), and (H.4.10); particularly selected from (H.1.5), (H.2.2), (H.2.5), (H.3.2), and (H.4.9).

[0248] Also preferred is a ternary mixture based on the binary mixture disclosed herein, comprising at least one active compound as an additional component 3), wherein the at least one active compound is selected from group I), more preferably from compounds (I.1.1), (I.1.2), (I.2.1), (I.2.2), (I.2.3) and (I.2.4).

[0249] Also preferred is a ternary mixture based on the binary mixture disclosed herein, which includes at least one active compound as an additional component 3), the at least one active compound being selected from group J), more preferably from compounds (J.1.2), (J.1.3), (J.1.4), (J.1.5), (J.1.8), and (J.1.12).

[0250] Also preferred is a ternary mixture based on the binary mixture disclosed herein, which includes at least one active compound as an additional component 3), the at least one active compound being selected from group K), more preferably from compounds (K.1.13), (K.1.47) and (K.1.54).

[0251] Also preferred are ternary mixtures based on the binary mixtures disclosed herein, comprising a biocide as an additional component 3), wherein the biocide is selected from groups L1), L3) to L5), preferably selected from those indicated above as (L.1.2), (L.1.3), (L.1.4), (L.1.5), (L.1.6), (L.1.7), (L.1.8), (L.1.10), (L.1.11), (L.1.12), (L.1.13), (L.1.14), (L.1.15), (L.1.17), (L.1.18), (L.1.19), (L.1... .20), (L.1.21), (L.1.25), (L.1.26), (L.1.27), (L.1.32)?, (L.3.1); (L.3.9), (L.3.16), (L .3.17), (L.5.1), (L.5.2), (L.5.3), (L.5.4), (L.5.5), (L.5.6), (L.5.7), (L.5.8); (L.4.2) The strains selected from (L.4.1) are preferred; even more preferably from (L.1.2), (L.1.6), (L.1.7), (L.1.8), (L.1.11), (L.1.12), (L.1.13), (L.1.14), (L.1.15), (L.1.18), (L.1.19), (L.1.20), (L.1.21), (L.3.1); (L.3.9), (L.3.16), (L.3.17), (L.5.1), (L.5.2), (L.5.5), (L.5.6); (L.4.2) and (L.4.1). These mixtures are particularly suitable for treating propagating material, i.e., for seed treatment purposes, and are equally suitable for soil treatment. These seed treatment mixtures are particularly suitable for crops such as monocots (e.g., cereals, corn) and dicots (e.g., vegetables and legumes such as soybeans).

[0252] Also preferred are ternary mixtures based on the binary mixtures disclosed herein, comprising a biocide selected from groups L1) and L3) as an additional component 3). And L4), preferably selected from (L1.1), (L1.2), (L1.3), (L1.6), (L1.7), (L1.9), (L1.11), (L1.12), (L1.13), (L1.14), (L1.15), (L1.17), (L1.18), (L1.22), (L1.23), (L1.24), (L1.25), (L1.26), (L1.27), (L2.2); (L3.2), (L3.3), (L3.4), (L3.5), (L3.6), (L3.7), (L3.3). The strains selected are (L.8), (L.3.10), (L.3.11), (L.3.12), (L.3.13), (L.3.14), (L.3.15), (L.3.18), (L.3.19); and (L.4.2), even more preferably selected from (L.1.2), (L.1.7), (L.1.11), (L.1.13), (L.1.14), (L.1.15), (L.1.18), (L.1.23), (L.3.3), (L.3.4), (L.3.6), (L.3.7), (L.3.8), (L.3.10), (L.3.11), (L.3.12), (L.3.15), and (L.4.2). These mixtures are particularly suitable for leaf treatment.

[0253] Also preferred is a ternary mixture based on the binary mixture disclosed herein, comprising at least one active compound as an additional component 3), wherein the at least one active compound is selected from group M), more preferably from compounds (M.1.6), (M.1.24), (M.1.25), (M.1.28), (M.1.29), and (M.1.30).

[0254] Also preferred is a ternary mixture based on the binary mixture disclosed herein, which includes at least one active compound as an additional component 3), the at least one active compound being selected from group N), more preferably from compounds (N.7.3), (N.7.4), (N.7.5), and (N.13.13).

[0255] Also preferred is a ternary mixture based on the binary mixture disclosed herein, comprising at least one active compound as an additional component 3), wherein the at least one active compound is selected from group O), more preferably from compounds (O.2.4), (O.4.5), (O.4.7), (O.4.8), (O.5.1), (O.26.2), (O.27.17), (O.27.101), and (O.27.102).

[0256] Compound I and its compositions are suitable as fungicides, effective against a broad spectrum of plant pathogenic fungi, including soil-borne fungi, particularly those from the classes Plasmodiomycetes, Oomycetes, Chytrididae, Zygomycetes, Ascomycetes, Basidiomycetes, and Fungi imperfecti. They can be used in crop protection as foliar fungicides, seed dressing fungicides, and soil fungicides.

[0257] Compound I and its compositions are preferably used to control plant pathogenic fungi in the following: various cultivated plants, such as cereals, such as wheat, rye, barley, triticale, oats, or rice; beets, such as sugar beets or forage beets; fruits, such as pome (apples, pears, etc.), drupes (such as plums, peaches, apricots, cherries), or soft fruits, also known as berries (strawberries, raspberries, blackberries, currants, etc.); legumes, such as lentils, peas, alfalfa, or soybeans; oilseed plants, such as rapeseed, mustard, olives, sunflowers, coconuts, cocoa beans, castor oil plants, oil palms, peanuts, or soybeans; cucurbits, such as squash, cucumbers, or melons; fiber plants, such as cotton, flax, hemp, etc. Or jute; citrus fruits, such as oranges, lemons, grapefruits, or tangerines; vegetables, such as spinach, lettuce, asparagus, cabbage, carrots, onions, tomatoes, potatoes, gourds, or red peppers; laurel plants, such as avocados, cinnamon, or camphor; energy and raw material plants, such as corn, soybeans, rapeseed, sugarcane, or oil palm; corn; tobacco; nuts; coffee; tea; bananas; grapevines (table grapes and grape juice vines); hops; turfgrass; stevia (also known as stevia); natural rubber plants; or ornamental and forest plants, such as flowers, shrubs, broad-leaved trees, or evergreen trees (conifers, eucalyptus, etc.); plant propagation materials, such as seeds; and crop materials of these plants.

[0258] More preferably, compound I and its compositions are used to control fungi in the following: field crops, such as potatoes, sugar beets, tobacco, wheat, rye, barley, oats, rice, corn, cotton, soybeans, rapeseed, legumes, sunflowers, coffee, or sugarcane; fruits; vines; ornamental plants; or vegetables, such as cucumbers, tomatoes, green beans, or squash.

[0259] The term "plant propagation material" should be understood to refer to all reproductive parts of a plant, such as seeds; and nutrient plant material that can be used for plant propagation, such as cuttings and tubers (e.g., potatoes). This includes seeds, roots, fruits, tubers, bulbs, rhizomes, shoots, buds, and other parts of a plant; including seedlings and young plants that are transplanted after germination or emergence.

[0260] Preferably, plant propagation material is treated with compound I and its compositions for the control of fungi in the following: cereals, such as wheat, rye, barley and oats; rice, corn, cotton and soybeans.

[0261] According to the present invention, all the above-mentioned cultivated plants should be understood to include all species, subspecies, variants, varieties and / or hybrids belonging to the corresponding cultivated plants, including but not limited to winter and spring varieties, especially cereals such as wheat and barley, and rapeseed, such as winter wheat, spring wheat, winter barley, etc., further including dwarf, semi-dwarf and full-dwarf varieties and / or hybrids with reduced height and thicker and shorter stems, such as dwarf maize (also known as "smart maize"), semi-dwarf wheat and dwarf rice.

[0262] Maize, also known as Indian maize or Zea mays, includes all varieties of maize, such as feed maize and sweet maize. According to the present invention, this includes all maize or maize subspecies and / or varieties, particularly floury maize (Zea mays var. amylacea), popcorn maize (Zea mays var. everta), dent maize (Zea mays var. indentata), flint maize (Zea mays var. indurata), sweet maize (Zea mays var. saccharata and var. rugosa), waxy maize (Zea mays var. ceratina), amylomaize (amylomaize), pod maize, or wild maize (Zea mays var. tunicata). tunicata) and striped maize (maize japonica variety (Zea mays var. japonica)).

[0263] Most soybean cultivars can be classified as either indeterminate or determinate, while wild soybean (Glycine soja) (the wild ancestor of soybean) is indeterminate (PNAS [Proceedings of the National Academy of Sciences] 2010, 107 (19) 8563-8568). Indeterminate varieties (maturity group, MG 00 to MG 4.9) are characterized by continuous vegetative growth after flowering begins, while determinate soybean varieties (MG 5 to MG 8) are characterized by having completed most of their vegetative growth by the time flowering begins. According to the present invention, all soybean cultivars or varieties, particularly indeterminate and determinate varieties or varieties, are included.

[0264] The term "cultivated plant" should be understood to include plants that have been modified through mutagenesis or genetic engineering to provide new traits or modify existing traits. Mutagenesis includes random mutagenesis using X-rays or mutagenic chemicals, and also includes targeted mutagenesis to produce mutations at specific loci in the plant genome. Targeted mutagenesis often uses oligonucleotides or proteins such as CRISPR / Cas, zinc finger nucleases, TALENs, or broad-spectrum nucleases. Genetic engineering typically uses recombinant DNA technology to produce modifications in the plant genome that are not readily available in nature through hybridization, mutagenesis, or natural recombination. Typically, one or more genes are integrated into the plant genome to add or improve or modify traits. These integrated genes are also called transgenes, and plants containing such transgenes are called transgenic plants. Plant transformation processes typically produce several transformation events, which differ at the genomic loci in which the transgene has been integrated. Plants containing a specific transgene at a specific genomic locus are often described as containing a specific "event," identified by the name of that specific event. Traits that have been introduced into plants or modified include herbicide tolerance, insect resistance, increased yield, and tolerance to abiotic conditions such as drought.

[0265] Herbicide tolerance has been developed through mutagenesis and genetic engineering. Plants induced to tolerate acetyllactate synthase (ALS) inhibitor herbicides through mutagenesis and breeding are available, for example, under the name Clearfield®. Herbicide tolerance to glyphosate, glufosinate, 2,4-D, dicamba, oxynil herbicides (such as bromobenzonitrile and iodobenzonitrile), sulfonylurea herbicides, ALS inhibitors, and 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors (like isoxaflutole and mesotrione) has been developed through transgenic technology.

[0266] Transgenic organisms providing herbicide tolerance traits include: glyphosate tolerance: cp4 epsps, epspsgrg23ace5, mepsps, 2mepsps, gat4601, gat4621, goxv247; glufosinate tolerance: pat and bar; 2,4-D tolerance: aad-1, aad-12; dicamba tolerance: dmo; benzyl nitrile herbicide tolerance: bxn; sulfonylurea herbicide tolerance: zm-hra, csr1-2, gm-hra, S4-HrA; ALS inhibitor tolerance: csr1-2; and HPPD inhibitor tolerance: hppdPF, W336, avhppd-03.

[0267] Transgenic maize events containing herbicide tolerance genes include, but are not limited to, DAS40278, MON801, MON802, MON809, MON810, MON832, MON87411, MON87419, MON87427, MON88017, MON89034, NK603, GA21, MZHG0JG, HCEM485, VCO-Ø1981-5, 676, 678, 680, 33121, 4114, 59122, 98140, Bt10, Bt176, CBH-351, DBT418, DLL25, MS3, MS6, MZIR098, T25, TC1507, and TC6275. Transgenic soybean events containing herbicide tolerance genes include, but are not limited to, GTS 40-3-2, MON87705, MON87708, MON87712, MON87769, MON89788, A2704-12, A2704-21, A5547-127, A5547-35, DP356043, DAS44406-6, DAS68416-4, DAS-81419-2, GU262, SYHTØH2, W62, W98, FG72, and CV127. Transgenic cotton events containing herbicide tolerance genes include, but are not limited to, 19-51a, 31707, 42317, 81910, 281-24-236, 3006-210-23, BXN10211, BXN10215, BXN10222, BXN10224, MON1445, MON1698, MON88701, MON88913, GHB119, GHB614, LLCotton25, T303-3, and T304-40. Transgenic canola events containing herbicide tolerance genes include, but are not excluded, MON88302, HCR-1, HCN10, HCN28, HCN92, MS1, MS8, PHY14, PHY23, PHY35, PHY36, RF1, RF2, and RF3.

[0268] Transgenic genes providing insect resistance are preferably toxin genes from Bacillus species and their synthetic variants, such as cry1A, cry1Ab, cry1Ab-Ac, cry1Ac, cry1A.105, cry1F, cry1Fa2, cry2Ab2, cry2Ae, mcry3A, ecry3.1Ab, cry3Bb1, cry34Ab1, cry35Ab1, cry9C, vip3A(a), and vip3Aa20. Additionally, plant-derived transgenic genes, such as those encoding protease inhibitors like CpTI and pinII, can be used. Another approach utilizes transgenic genes such as dvsnf7 to produce double-stranded RNA in plants.

[0269] Transgenic maize events containing insecticidal protein genes or double-stranded RNA include, but are not limited to, Bt10, Bt11, Bt176, MON801, MON802, MON809, MON810, MON863, MON87411, MON88017, MON89034, 33121, 4114, 5307, 59122, TC1507, TC6275, CBH-351, MIR162, DBT418, and MZIR098. Transgenic soybean events containing insecticidal protein genes include, but are not limited to, MON87701, MON87751, and DAS-81419. Transgenic cotton events containing insecticidal protein genes include, but are not limited to, SGK321, MON531, MON757, MON1076, MON15985, 31707, 31803, 31807, 31808, 42317, BNLA-601, Event1, COT67B, COT102, T303-3, T304-40, GFMCry1A, GK12, MLS 9124, 281-24-236, 3006-210-23, GHB119, and SGK321.

[0270] Cultivated plants with increased yields have been produced by using transgenic athb17 (e.g., maize event MON87403) or bbx32 (e.g., soybean event MON87712).

[0271] Cultivated plants with improved oil content have been produced using the following transgenic genes: gm-fad2-1, Pj.D6D, Nc.Fad3, fad2-1A, and fatb1-A (e.g., soybean events 260-05, MON87705, and MON87769).

[0272] Tolerance to abiotic conditions (such as drought) has been developed through the use of transgenic cspB (maize event MON87460) and Hahb-4 (soybean event IND-ØØ41Ø-5).

[0273] Traits are typically combined by combining genes during transformation events or by combining different events during the breeding process, resulting in cultivated plants with superimposed traits. Preferred combinations of traits include combinations of herbicide tolerance traits from different groups of herbicides, combinations of insect tolerance to different insect species, particularly to Lepidoptera and Coleoptera, combinations of herbicide tolerance with resistance to one or more types of insects, combinations of herbicide tolerance with increased yield, and combinations of herbicide tolerance with tolerance to abiotic conditions.

[0274] Plants containing single or superimposed traits, as well as the genes and events that provide these traits, are well known in the field. For example, detailed information on mutagenic or integrated genes and corresponding events is available from the websites of organizations such as the International Service for the Application of Agri-biotech Applications (ISAAA) (http: / / www.isaaa.org / gmapprovaldatabase) and the Centre for Environmental Risk Assessment (CERA) (http: / / cera-gmc.org / GMCropDatabase). Further information regarding specific events and methods for detecting these events can be found in WO 01 / 031042, WO 01 / 041558, WO 01 / 041558, WO 02 / 036831, WO 11 / 153186, and WO 13 / 003558 for canola events MS1, MS8, RF3, GT73, MON88302, and KK179; and in WO 02 / 034946, WO 03 / 036831, WO 11 / 153186, and WO 13 / 003558 for cotton events MON1445, MON15985, MON531 (MON15985), LLCotton25, MON88913, COT102, 281-24-236, 3006-210-23, COT67B, GHB614, T304-40, GHB119, MON88701, and 81910 ...MON531 (MON15985), MON531 (MON15985), MON531 (MON15985), MON531 (MON15985), MON531 (MON15 02 / 100163、WO 02 / 100163、WO 03 / 013224、WO 04 / 072235、WO 04 / 039986、WO 05 / 103266、WO 05 / 103266、WO 06 / 128573、WO 07 / 017186、WO 08 / 122406, WO 08 / 151780, WO 12 / 134808, WO 13 / 112527;For the corn incident, GA21, MON810, DLL25, TC1507, MON863, MIR604, LY038, MON88017, 3272, 59122, NK603, MIR162, MON89034, 98140, 32138, MON87460, 5307, 4114, MON87427, DAS40278, MON87411, 33121, MON87403, and MON87419 can be found in WO 98 / 044140, US 02 / 102582, US 03 / 126634, WO 04 / 099447, WO 04 / 011601, WO 05 / 103301, WO 05 / 061720, WO 05 / 059103, and WO 06 / 098952、WO 06 / 039376、US 2007 / 292854、WO07 / 142840、WO 07 / 140256、WO 08 / 112019、WO 09 / 103049、WO 09 / 111263、WO 10 / 077816、WO11 / 084621、WO 11 / 062904、WO 11 / 022469、WO 13 / 169923、WO 14 / 116854、WO 15 / 053998, WO15 / 142571; for potato events E12, F10, J3, J55, V11, X17, Y9, see WO 14 / 178910, WO 14 / 178913, WO 14 / 178941, WO 14 / 179276, WO 16 / 183445, WO 17 / 062831, WO 17 / 062825; for the rice incident LLRICE06, LLRICE601, LLRICE62, see WO 00 / 026345, WO 00 / 026356, WO 00 / 026345;Furthermore, for soybean events H7-1, MON89788, A2704-12, A5547-127, DP305423, DP356043, MON87701, MON87769, CV127, MON87705, DAS68416-4, MON87708, MON87712, SYHT0H2, DAS81419, DAS81419 x DAS44406-6, MON87751, these can be found in WO 04 / 074492, WO 06 / 130436, WO06 / 108674, WO 06 / 108675, WO 08 / 054747, WO 08 / 002872, WO 09 / 064652, WO 09 / 102873, WO10 / 080829, WO10 / 037016, WO11 / 066384, WO11 / 034704, WO12 / 051199, WO12 / 082548, WO13 / 016527, WO13 / 016516, WO14 / 201235.

[0275] The application of compound I and its combinations to cultivated plants can result in effects specific to cultivated plants containing a particular transgene or event. These effects may involve alterations in growth behavior or resistance to biotic or abiotic stresses. Such effects may in particular include increased yield, increased resistance or tolerance to insect, nematode, fungus, bacteria, mycoplasma, virus, or viroid pathogens, as well as early vigor, early or delayed maturity, cold or heat tolerance, and altered amino acid or fatty acid profiles or contents.

[0276] Compound I and its combinations are particularly suitable for controlling the pathogens causing the following plant diseases:

[0277] White rust (A. candida) species on ornamental plants, vegetables (e.g., white rust fungus), and sunflowers (e.g., white rust fungus *A. tragopogonis*); *Albugo* species (white rust disease) on vegetables (e.g., *Albugo* dauci or *Albugo* porri), rapeseed (*Albugo* brassicicola or *Albugo* brassicae), sugar beets (*Albugo* tenuis), fruits (e.g., *Albugo* grandis), rice, soybeans, potatoes, and tomatoes (e.g., *Albugo* solani, *Albugo* or *Albugo* alternata), tomatoes (e.g., *Albugo* solani or *Albugo* alternata), and wheat (e.g., *Albugo* wheat). Alternaria species on *Alternaria triticina* (Alternaria leaf spot); Aphanomyces species on sugar beets and vegetables; Ascochyta species on cereals and vegetables, such as *A. tritici* on wheat (anthracnose) and *A. hordei* on barley; *Aureobasidium zeae* (synonym *Kapatiella zeae*) on maize; Bipolaris and Drechslera species (sexual form: *Cochliobolus* species), such as *D. maydis* on maize (small leaf spot) or *B. zeicola* on maize (large leaf spot), such as *B. zeicola* on cereals (root rot). Sorokiniana) and, for example, B. oryzae on rice and turfgrass; Blumeria graminis (formerly known as Erysiphe graminis) on cereals (e.g., wheat or barley) (powdery mildew); Botrytis cinerea (sexual form: Botryotinia fuckeliana: gray mold) on fruits and berries (e.g., strawberries), vegetables (e.g., lettuce, carrots, celery, and cabbage); Botrytis squamosa or Botrytis squamosa on onion family plants, rapeseed, ornamental plants (e.g., Beliptica), vines, forest plants, and wheat.allii); *Bremia lactucae* on lettuce (downy mildew); *Ceratocystis* species (synonym Ophiostoma) on broadleaf and evergreen trees (rot or wilting), such as *C. ulmi* on elm trees (Dutch elm disease); maize (e.g., gray leaf spot: *C. zeae-maydis*), rice, sugar beets (e.g., *C. beticola*), sugarcane, vegetables, coffee, soybeans (e.g., *C. sojina* or *C. kikuchii*) and *Cercospora* species on rice (Cercospora leaf spot); *Cladobotryum* species (synonym Dactylium) on mushrooms (e.g., *C. mycophilum* (formerly known as *Dactylium dendriticum*)). Dendroides), sexual form: Nectria albertinii, pink parasite (Nectria rosella) synonym Hypomyces rosellus; tomato (e.g. C. fulvum: leaf mold) and Cladosporium species on cereals, such as C. herbarum on wheat (black ear); Claviceps purpurea on cereals (ergot); maize (C. carbonum), cereals (e.g. C. sativus, asexual form: B. sorokiniana) and rice (e.g. C. miyabeanus, asexual form: H. rice long-spore). Species of the genus *Helminthosporium* (asexual form: *Helminthosporium*) on *oryzae* (leaf spot); cotton (e.g., *C. gossypii*), maize (e.g., *C. graminicola*: anthracnose and stem rot), soft fruit, potato (e.g., *C. coccodes*: black spot), bean (e.g., *C. lindemuthianum*), soybean (e.g., *C. truncatum* or *C. gloeosporioides*), vegetables (e.g., *C. lagenarium* or *C. capsici*), fruit (e.g., *C. acutatum*), coffee (e.g., *C. coffee*).*Coffeanum* or *C. kahawae* and various crops (*C. gloeosporioides*) species of *Colletotrichum* (sexual form: *Glomerella*) (anthracnose); *Corticium* species, such as *C. sasakii* on rice (sheath blight); *Corynespora cassiicola* on soybeans, cotton, and ornamental plants (leaf spot); *Cycloconium* species, such as *C. oleaginum* on olive trees; fruit trees, vines (e.g., *C. liriodendri*, sexual form: *Neonectria liriodendri*): Black Foot disease. Diseases) and Cylindrocarpon species on ornamental plants (e.g., fruit tree canker or vine decay, sexual type: *Nectria* or *Neonectria* species); *Dematophoranecatrix* on soybeans (sexual type: *Rosellinia necatrix*) (root and stem rot); *Diaporthe* species, such as *D. phaseolorum* on soybeans (damping-off); corn, cereals such as barley (e.g., *D. teres*, net blotch) and wheat (e.g., *D. tritici-repentis*, brown spot disease). *Pyrenophora* species on rice and turfgrass (synonyms: *Pyrenophora*, sexual form: *Pyrenophora*); *Esca* (dieback, apoplexy) on vines, caused by *Formitiporia punctata* (synonyms: *Phellinus punctata*), *F. mediterranea*, *Phaeomoniella chlamydospora* (formerly *Phaeoacremonium chlamydosporum*), *Phaeoacremonium aleophilum*, and / or *Botryosphaeria obtusa*; pear fruit (*E. pear scab*).Species of the genus *Elsinoe* on raspberries (*E. veneta*): anthracnose, and vines (*E. ampelina*): anthracnose; *Entyloma oryzae* on rice (leaf smut); species of the genus *Epicoccum* on wheat (black mold); *E. betae* on sugar beets, *E. pisi* on vegetables such as gourds (e.g., *E. cichoracearum*), cabbage, and rapeseed (e.g., *E. cruciferarum*) (powdery mildew); and *Eutypa* on fruit trees, vines, and ornamental trees. (Cytosporina lata) (Eutypa canker or shoot blight, asexual form: Cytosporina lata, synonym Libertella blepharis); Exserohilum species (synonym: Long Helium) on maize (e.g., E. turcicum); Fusarium species (sexual form: Gibberella) on various plants (wilt, root or stem rot), such as Fusarium graminearum or Fusarium culmorum on cereals (e.g., wheat or barley) (root rot, scab, or headblight), Fusarium oxysporum on tomatoes, and Fusarium solani (F. sp.) on soybeans (F. sp.). *F. glycines*, a new synonym for the pathogen causing soybean sudden death syndrome (F. virguliforme) and *F. tucumaniae* and *F. brasiliense* (both causing sudden death syndrome), and *F. verticillioides* on maize; *Gaeumannomyces graminis* (take-all disease) on cereals (e.g., wheat or barley) and maize; *G. zeae* species on cereals (e.g., *G. fujikuroi*: Bakanae disease) and rice (e.g., *G. fujikuroi*: Bakanae disease); *Glomerella cingulata* on vines, pome fruits and other plants, and *G. cotyledonum* on cotton.gossypii; grain-staining complex on rice; *Guignardia bidwellii* on vines (black rot); *Gymnosporangium* species on Rosaceae and juniper, such as *G. sabinae* on pear (rust); *Hemileia* species (synonym *Hemileia*, sexual form: *Hemileia*) on corn, cereals, potatoes, and rice; *H. vastatrix* species on coffee (coffee leaf rust); *Isariopsis clavispora* (synonym *Cladosporium vitis*) on vines; *Macrophomina phaseolina* (synonym *Macrophomina phaseoli*) on soybeans and cotton (root and stem rot); *Microdochium* on cereals (e.g., wheat or barley). *Fusarium nivale* (synonym) (powdery mildew); *Microsphaera diffusa* (powdery mildew) on soybeans; *Monilinia* species on drupes and other Rosaceae plants, such as *M. laxa*, *M. fructicola*, and *M. fructigena* (synonyms *Monilia* species: flower blight and branch blight, brown rot); *Mycosphaerella* species on cereals, bananas, soft fruits, and peanuts, such as *M. graminicola* on wheat (asexual form: *Zymoseptoria tritici*, formerly known as *Septoria tritici*: *Zymoseptoria tritici* leaf spot), or *M. feijiensis* on bananas. *Fijiensis* (synonym: *Pseudocercosporafijiensis*: black Sigatoka disease) and *M. musicola*, *M. arachidicola* (synonym: *M. arachidis* or *Cercospora arachidis*) and *M. berkeleyi* on peanuts, *M. pisi* on peas, and *M. brassicae* (*M.*).brassiciola; Peronospora species (downy mildew) on cabbage (e.g., *P. brassicae*), rapeseed (e.g., *P. parasitica*), onion (e.g., *P. destructor*), tobacco (*P. tabacina*), and soybean (e.g., *P. manshurica*); *P. meibomiae* and *P. meibomiae* (soybean rust) on soybean; *Phialophora* species, such as on vines (e.g., *P. tracheiphila* and *P. tetraspora*) and soybean (e.g., *P. gregata*: stem rot); *Phoma lingam* (synonym *Leptosphaeria biglobosa*) and *Leptosphaeria glomeratum* on rapeseed and cabbage. *P. maculans*: root and stem rot) and *P. betae* on sugar beets (root rot, leaf spot, and damping-off), and *P. zeae-maydis* on maize (synonym *Phyllostica zeae*); *Phomopsis* species on sunflowers, vines (e.g., *P. viticola*: vine and leaf spot) and soybeans (e.g., stem rot: *P. phaseoli*, sexual type: *Diaporthe phaseolorum*); *Physoderma maydis* on maize (brown spot); *Phytophthora* species on various plants (wilt, root, leaf, fruit, and stem rot), such as red peppers and gourds (e.g., *P. capsici*), and soybeans (e.g., *P. damascene*). *Phytophthora megasperma*, synonym of *P. sojae*, *P. infestans* (late blight) on potatoes and tomatoes, and *P. ramorum* (sudden death of oak trees); *Plasmodiophora brassicae* (club root) on cabbage, rapeseed, radish, and other plants; species of the genus *Plasmopara*, such as *P. viticola* (grape downy mildew) on vines and *P. hols* (sunflower) on sunflowers.halstedii); species of the genus *Podosphaera* (powdery mildew) on Rosaceae plants, hops, pome fruits, and soft fruits, such as *P. leucotricha* on apples and *P. xanthii* on gourds; species of the genus *Polymyxa* on cereals such as barley and wheat (*P. graminis*) and sugar beets (*P. betae*), and viral diseases transmitted by these; *Pseudocercosporella* herpotrichoides (synonyms *Oculimacula yallundae*, *O. acuformis*: eye spot, sexual form: *Tapesia yallundae*) on cereals such as wheat or barley; *Pseudoperonospora* (downy mildew) on various plants, such as *P. columbia* on gourds. *P. humili* on *cubensis* or hops; *Pseudopezicula tracheiphila* (red fire disease or rotbrenner, asexual form: *P. spp.*) on vines; *Puccinia* species (rust diseases) on various plants, such as *P. triticina* (brown rust or leaf rust) on cereals (e.g., wheat, barley, or rye), *P. striiformis* (stripe rust or yellow rust), *P. hordei* (dwarf rust), *P. graminis* (stem rust or black rust), or *P. recondita* (brown rust or leaf rust) on sugarcane, *P. kuehnii* (citrus rust) on asparagus. asparagi); species of the genus *Pyrenopeziza*, such as *P. brassicae* on rapeseed; *Pyrenophora tritici-repentis* (asexual form: *Drechslera tritici-repentis*) (brown spot disease) on wheat, or *P. teres* (net blotch disease) on barley; species of the genus *Pyricularia*, such as *P. oryzae* (sexual form: *Magnaporthe grisea*) on rice, and *P. gracilis* on turfgrass and cereals.*Pythium* species (damping-off) on grasses, rice, corn, wheat, cotton, rapeseed, sunflower, soybean, sugar beet, vegetables, and many other plants (e.g., *P. ultimum* or *P. aphamidatum*) and *P. oligandrum* on mushrooms; *Ramularia* species, such as *R. collo-cygni* on barley (for *Ramularia* leaf spot, physiological leaf spot), *R. areola* on cotton (sexual form: *Mycosphaerella areola*), and *R. beticola* on sugar beet; *Rhizoctonia* species on cotton, rice, potato, grasses, corn, rapeseed, potato, sugar beet, vegetables, and many other plants, such as *R. rhizoctonia* on soybean. * Rhizoctonia solani* (root and stem rot); *Rhizoctonia solani* (sheath blight) on rice; or *Rhizoctonia cerealis* (rhizoctonia solani leaf blight) on wheat or barley; *Rhizopus stolonifer* (black mold, soft rot) on strawberries, carrots, cabbage, vines, and tomatoes; *Rhynchosporium secalis* and *R. commune* (scald) on barley, rye, and triticale; *Sarocladium oryzae* and *S. attenuatum* (sheath rot) on rice; and *S. minor* and *S. attenuatum* (sclerotiorum) on vegetables. *Sclerotiorum* species (stalk rot or white mold) on field crops such as rapeseed, sunflower (e.g., *Sclerotinia*) and soybean; *S. rolfsii* (synonym *Athelia rolfsii*) on soybean, peanut, vegetables, corn, cereals and ornamental plants; *Septoria* species on various plants, such as *S. glycines* (brown spot) on soybean, *S. tritici* (synonym *Zymoseptoria tritici*, *S. tritici* leaf spot) on wheat, and *S. gleminifera* (*S. tritici*) on cereals.nodorum (synonym: Stagonospora nodorum) (spot blight of the genus Stagonospora); Uncinula necator (synonym: Erysiphe necator) (powdery mildew, asexual form: Oidium tuckeri) on vines; Setosphaeria species (leaf blight) on maize (e.g., S. turcicum, synonym: Helminthosporium turcicum) and on turfgrass; Ustilago reiliana (spiny smut) on maize, Sphacelotheca species (smut) on sorghum and sugarcane; Sphaerotheca fuliginea (synonym: Podosphaera) on gourds. xanthii: powdery mildew); Spongosspora subterranea (powdery mildew) on potatoes and the viral diseases transmitted by it; Stagonospora species on cereals, such as S. nodorum on wheat (spot blight, sexual form: Leptosphaeria nodorum [synonym Phaeosphaerianodorum], synonym Septoria nodorum]); Synchytrium endobioticum on potatoes (potato canker); Taphrina species, such as T. deformans on peaches (leaf curl) and T. plum (plum) on plum trees. *Prunus pruni* (plum pocket disease); *Thielaviopsis* species (black root rot) on tobacco, pome, vegetables, soybeans, and cotton, such as *T. basicola* (synonym *Chalara elegans*); *Tilletia* species (common bunt or stinking smut) on cereals, such as *T. tritici* (synonym *T. caries*, wheat bunt) and *T. dwarf smut* on wheat.Controversa (dwarf smut); Trichoderma harzianum on mushrooms; Typhula incarnata on barley or wheat (grey snow mold); species of the genus Urocystis, such as U. occulta on rye (stem smut); vegetables such as beans (e.g., U. appendiculatus, synonym U. phaseoli), sugar beets (e.g., U. betae or U. beticola), and dried beans (e.g., U. vignae, U. pisi, U. viciae-fabae, and U. daphnia). Species of the genus *Uromyces* (rust) on *Fabae*; species of the genus *Ustilago* (loose smut) on cereals (e.g., *U. nuda* and *U. avaenae*), maize (e.g., *U. maydis*: maize smut), and sugarcane (loose smut); species of the genus *Venturia* (scab) on apples (e.g., *V. inaequalis*) and pears; and species of the genus *Verticillium* (wilt) on various plants such as fruits and ornamental plants, vines, soft fruits, vegetables, and field crops, such as *V. longisporum* on rapeseed, *V. dahliae* on strawberries, rapeseed, potatoes, and tomatoes, and *V. fungicola* on mushrooms; and *Syngonium* fermentans on cereals.

[0278] Compound I and its combinations are particularly suitable for controlling pathogens of the following plant diseases: rust on soybeans and cereals (e.g., *Puccinia tritici* and *Puccinia stipelenii* on soybeans; *Puccinia tritici* and *Puccinia stipelenii* on wheat); mildew on specialty crops, soybeans, rapeseed, and sunflowers (e.g., *Botrytis cinerea* on strawberries and vines; *Sclerotium sclerotiorum*, *Sclerotium sclerotiorum*, and *Sclerotium sclerotiorum* on rapeseed, sunflowers, and soybeans); Fusarium diseases on cereals (e.g., *Fusarium graminearum* and *Fusarium graminearum* on wheat); downy mildew on specialty crops (e.g., *Monosporium variegatum* on vines, *Phytophthora infestans* on potatoes); powdery mildew on specialty crops and cereals (e.g., *Hypericum variegatum* on vines, various powdery mildew species on specialty crops, *Brucella variegata* on cereals); and leaf spot on cereals, soybeans, and maize (e.g., *Synthia spp.* and *Synthia spp.* on cereals, *Synthia spp.* on soybeans, *Synthia spp.* on maize, and *Cercospora* species on maize).

[0279] In the most preferred embodiments, compound I, mixtures thereof with other active compounds as defined herein, and combinations thereof are particularly suitable for controlling the following plant diseases:

[0280] Alternaria species (Alternaria leaf spot) on vegetables (e.g., *Alternaria dauci* or *Alternaria porri*), rapeseed (*Alternaria brassicicola* or *Alternaria brassicae*), sugar beets (*Alternaria tenuis*), fruits (e.g., *Alternaria grandis*), rice, soybeans, potatoes, and tomatoes (e.g., *Alternaria solani*, *Alternaria cylindrica*, or *Alternaria alternata*), tomatoes (e.g., *Alternaria solani* or *Alternaria alternata*), and wheat (e.g., *Alternaria triticina*); *Aphanomyces* species on sugar beets and vegetables; and *Ascochyta* species on grains and vegetables, such as *Ascochyta triticina* on wheat. *Botrytis tritici* (anthracnose) and *A. hordei* on barley; *Botrytis cinerea* (sexual form: *Botrytis fruticosa*: gray mold) on fruits and berries (e.g., strawberries), vegetables (e.g., lettuce, carrots, celery, and cabbage); *Botrytis squamosa* or *Botrytis squarrosa* on onion family plants, rapeseed, ornamental plants (e.g., *Botrytis elliptica*), vines, forest plants, and wheat. Allii); *Fusarium graminearum* (downy mildew) on lettuce; *Fusarium* species (sexual form: *Fusarium*) (wilt, root or stem rot), such as *Fusarium graminearum* or *Fusarium graminearum* (root rot, scab, or scab) on cereals (e.g., wheat or barley); *Fusarium solani* (synonym *Fusarium solani*, a soybean-specific variant of *Fusarium graminearum*, a new synonym for soybean sudden death syndrome pathogen) on soybeans (e.g., wheat or barley); *Microsorum nivalis* (synonym *Fusarium nivalis*) (powdery mildew) on cereals (e.g., wheat or barley); *Pythium* species, such as *Pythium oryzae* (sexual form: *Pythium oryzae*: rice blast) on rice, and *Pythium glomeratum* on sedges and cereals; *Pythium* species (dampness), such as corn. The ultimate Pythium; Rhizoctonia species on cotton, rice, potato, turfgrass, corn, rapeseed, sugar beets, vegetables, and many other plants, such as Rhizoctonia solani (root and stem rot) on soybean, Rhizoctonia solani (sheath blight) on rice, or Rhizoctonia graminis (rhizoctonia solani spring leaf blight) on wheat or barley; Sclerotium sclerotiorum, Sclerotium sclerotiorum, and Sclerotium sclerotiorum on rapeseed, sunflower, and soybean; smut species on corn (smut) (e.g., Sclerotium sclerotiorum: smut); smut species on wheat, such as Sclerotium spp. (wheat smut) and Sclerotium dwarf (wheat smut); apple (e.g., V. sclerotium).*Inaequalis* and *Venturia* species on pears (scab); as well as *Verticillium* species (wilt) on various plants such as fruits and ornamental plants, vines, berries, vegetables, and field crops, such as *Verticillium longiflorum* on rapeseed, *Verticillium dahliae* on strawberries, rapeseed, potatoes, and tomatoes, and *Verticillium fungi* on mushrooms.

[0281] The mixtures A1-1 to A1-825 defined above are suitable for the control of gray mold and white mold diseases, especially Botrytis species and Sclerotinia species.

[0282] The mixtures A2-1 to A2-825 defined above are suitable for the control of gray mold and white mold diseases, especially Botrytis species and Sclerotinia species.

[0283] The mixtures A3-1 to A3-825 defined above are suitable for the control of gray mold and white mold diseases, especially Botrytis species and Sclerotinia species.

[0284] Mixtures A1-1 to A1-825 as defined above are suitable for controlling rice leaf, neck, nape, and panicle blast (especially *Pyricularia grisae*, formerly known as *Pyricularia oryzae*) and brown spot (*Cochliobolus miyabeanus*, formerly known as *Helminthosporium oryzae*; *Drechslera oryzae*; *Bipolaris oryzae*)); dirty panicle, including *Cercopsora oryzae*, *Curvularia lunata*, *Trichoconispadwickii*, *Sarocladium oryzae*, *Fusarium semitectum*; rice sheath blight (*Rhizoctonia solani* = *Thanatephorus*). cucumeris (also known as rice sheath blight fungus (Corticium sasakii))); rice seedling blight (Fusarium fujikuroi = Giberella fujikuroi)).

[0285] Mixtures A2-1 to A2-825 as defined above are suitable for controlling rice leaf, neck, nape, and panicle blast (especially *Pyrrosia lingua*, formerly known as *Pyrrosia lingua*) and brown spot (*Helicobacter oryzae*, formerly known as *Helicobacter oryzae*; *Helicobacter oryzae*; *Helicobacter oryzae*); dirty panicle, including *Cercospora oryzae*, *Curculigosporium lunata*, *Cryptospira oryzae*, *Fusarium solani*, *Fusarium solani*; rice sheath blight (*Rhizoctonia solani* = *Rhizoctonia solani* (also known as *Rhizoctonia solani*)); and rice bakanae disease (*Fusarium fusiforme* = *Fusarium fusiforme*).

[0286] Mixtures A3-1 to A3-825 as defined above are suitable for controlling rice leaf, neck, nape, and panicle blast (especially *Pyrrosia lingua*, formerly known as *Pyrrosia lingua*) and brown spot (*Helicobacter oryzae*, formerly known as *Helicobacter oryzae*; *Helicobacter oryzae*; *Helicobacter oryzae*); dirty panicle, including *Cercospora oryzae*, *Curculigosporium lunata*, *Cryptospira oryzae*, *Fusarium solani*, *Fusarium solani*; rice sheath blight (*Rhizoctonia solani* = *Rhizoctonia solani* (also known as *Rhizoctonia solani*)); and rice bakanae disease (*Fusarium fusiforme* = *Fusarium fusiforme*).

[0287] The mixtures A1-1 to A1-825 defined above are suitable for the control of diseases of pear and stone fruit, especially species of the genera *Aureobasidium*, *Sclerotium*, *Gnaphalium*, *Alternaria*, and *Diplocarpon mali* (*Marssonina coronaria*).

[0288] Mixtures A2-1 to A2-825 as defined above are suitable for the control of diseases in pear and stone fruit, especially species of the genera *Nepeta*, *Sclerotium*, *Pseudomonas*, *Alternaria*, and *Diplostomum majus*.

[0289] Mixtures A3-1 to A3-825 as defined above are suitable for the control of diseases in pear and stone fruit, especially species of the genera *Nepeta*, *Sclerotium*, *Pseudomonas*, *Alternaria*, and *Dioscorea maculata*.

[0290] Mixtures A1-1 to A1-825 as defined above are suitable for the control of Rhizoctonia solani diseases in several crops such as grass, cereals, potatoes, and leafy vegetables, especially Rhizoctonia solani.

[0291] Mixtures A2-1 to A2-825 as defined above are suitable for the control of Rhizoctonia solani diseases in several crops, such as grass, cereals, potatoes, and leafy vegetables, especially Rhizoctonia solani.

[0292] Mixtures A3-1 to A3-825 as defined above are suitable for the control of Rhizoctonia solani diseases in several crops, such as grasses, cereals, potatoes, and leafy vegetables, especially Rhizoctonia solani.

[0293] The mixtures A1-1 to A1-825 defined above are suitable for controlling storage-complex infections in pear and stone fruit, especially species of the genera *Gloeosporium*, *Penicillium*, *Botrytis*, *Pseudomonas*, *Sclerotinia*, *Sphaeropsis*, *Neofabraea*, and *Mucor*.

[0294] Mixtures A2-1 to A2-825 as defined above are suitable for controlling storage-related complex diseases in pear and stone fruit, especially species of the genera *Palmaria*, *Penicillium*, *Botrytis*, *Pseudomonas*, *Sclerotium*, *Oomycetes*, *Mexicania*, and *Mucor*.

[0295] Mixtures A3-1 to A3-825 as defined above are suitable for controlling storage-related complex diseases in pear and stone fruit, especially species of the genera *Palmaria*, *Penicillium*, *Botrytis*, *Pseudomonas*, *Sclerotium*, *Oomycetes*, *Mexicania*, and *Mucor*.

[0296] The mixtures A1-1 to A1-825 defined above are suitable for controlling various soil- and seed-borne pathogens, especially Fusarium species (Fusarium spp., such as Fusarium xanthoides and Fusarium graminearum), snow mold microsporidia, Cyclospora species, Ustilago species, Syngonium species, Rhizopus species, Cladosporium species, Rhizopus species, Ustilago species, and Rhizopus rhizoctonia).

[0297] It has been observed that plant pathogenic fungal communities, which are clearly composed of non-resistant strains, can readily develop resistance. These compounds can also be applied under conditions that completely prevent the formation of resistance and the spread of resistant strains. In this respect, it is useful that they also possess strong activity against non-resistant plant pathogenic fungi.

[0298] Various fungicide-resistant strains of plant pathogenic fungi have been reported, with resistance to one or more fungicides from various modes of action observed through target site mutations in the genes of the corresponding proteins (e.g., QoI (C3, see www.frac.info according to FRAC convention), quinone exo-labeled styracin binding subsite inhibitors (QoSI; C8) and quinone intra-labeled inhibitors (QiI; C4): CytB target protein; sterol demethylation (DMI, G1): Cyp51 / Erg11; carboxylamides (CAA, H5): CesA3; SDHI (C2): SdhB, SdhC, and SdhD; dicarboxylimides (E3): Os-1 (including Bos1, Daf1, etc.); ketoreductase inhibitors (KRI; Class III SBI; G3): Erg27; and oxidized sterol binding protein inhibitors (OSBPI; F9): ORP1).

[0299] Table M indicates examples of mutation sites in genes encoding such target proteins that result in single amino acid exchanges, deletions, or insertions listed in the corresponding target protein sequence, thereby conferring resistance to certain fungicides in plant pathogenic fungi (see also Pest Management Science 72(8) 2016: 1449-1459).

[0300] Table M:

[0301]

[0302]

[0303]

[0304]

[0305]

[0306]

[0307]

[0308]

[0309] Based on the comparison with reference sequences from pathogenic Phytophthora; G54E / K / R / V / W indicates the possibility of five different amino acid variations at position 54; Δ indicates the deletion of an amino acid; # indicates the insertion of an amino acid.

[0310] Therefore, compound I is particularly useful for controlling fungicide-resistant strains of plant pathogenic fungi as described in Table M. Such strains may possess one or more resistances derived from one or more mutations (including, but not limited to, the mutations listed in Table M) of one or more genes encoding target proteins of various fungicides, and / or resistance derived from overexpression of the corresponding target proteins.

[0311] Furthermore, some fungal strains may have developed so-called multidrug resistance, ultimately leading to broad cross-resistance to many structurally and functionally unrelated compounds. "Multidrug resistance" (MDR), also known as "multidirectional resistance" (PDR), describes a resistance phenomenon typically caused by the overexpression of certain membrane transport proteins, resulting in increased activity of efflux pumps that export certain substrates (e.g., mycotoxins and fungicidal compounds). Examples of such membrane transport proteins include ATP-binding cassette (ABC) transporters and the major cotransporter superfamily (MFS) transporters. Overexpression of membrane transport proteins can be confirmed, for example, by measuring the amount of the transporter or its corresponding mRNA. The measured mRNA amount can be, for example, 2, 5, 20, up to 100 times or more, relative to the mRNA amount of the corresponding fungicide-sensitive wild-type fungus.

[0312] Compound I of the present invention can be used to control plant diseases caused by multidrug-resistant (MDR) fungi. MDR fungi can also possess one or more types of resistance derived from one or more mutations (including, but not limited to, mutations listed in Table M) in one or more genes encoding target proteins of various fungicides, and / or resistance derived from overexpression of the target proteins. Therefore, Compound I is also particularly useful for controlling such MDR fungi.

[0313] Compound I and its compositions are also suitable for the prevention and control of harmful microorganisms in the protection of stored products or harvests and in the protection of materials.

[0314] The term "stored product or harvest" should be understood to refer to natural substances of plant or animal origin and their processing forms desired for long-term preservation. Plant-derived stored products, such as stems, leaves, tubers, seeds, fruits, or grains, can be preserved in their freshly harvested state or through processing methods such as pre-drying, moistening, crushing, grinding, pressing, or baking (processing also known as post-harvest treatment). Timber also falls under the definition of stored products, whether in log form, such as construction timber, transmission towers, and fences, or in finished product form, such as furniture or objects made of wood. Animal-derived stored products are hides, leather, fur, hair, etc. Preferably, "stored product" should be understood to refer to natural substances of plant origin and their processing forms, more preferably fruits and their processing forms, such as pome, stone fruit, soft fruit, and citrus fruits and their processing forms, wherein the application of compound I and its combinations can also prevent adverse effects such as rot, discoloration, or mold.

[0315] The term “protection of materials” should be understood to mean protecting technical and non-living materials such as adhesives, glues, wood, paper, cardboard, textiles, leather, paint dispersions, plastics, coolant lubricants, fibers, or fabrics from contamination and damage by harmful microorganisms such as fungi and bacteria.

[0316] When used for the protection of materials or stored products, the amount of active substance applied depends on the type of application and the desired effect. Typically, the amount applied for the protection of materials is 0.001 g to 2 kg, preferably 0.005 g to 1 kg of active substance per cubic meter of treated material.

[0317] Compound I and its compositions can be used to improve plant health. The present invention also relates to a method for improving plant health by treating plants, their propagation material, and / or the sites where plants are growing or will grow, respectively, with effective amounts of Compound I and its compositions.

[0318] The term "plant health" should be understood as referring to the condition of plants and / or their products, determined by multiple indicators, individually or in combination, such as yield (e.g., increased biomass and / or increased content of valuable components), plant vigor (e.g., improved plant growth and / or greener leaves ("greening effect")), quality (e.g., improved content or composition of certain components), and tolerance to abiotic and / or biotic stresses. These plant health indicators may be interdependent or mutually influential.

[0319] Compound I is used as is or in combination form to treat fungi with an effective amount of the active substance, protecting plants, plant propagation material (such as seeds), soil, surfaces, materials, or rooms from fungal infection. Application can be carried out before or after the plants, plant propagation material (such as seeds), soil, surfaces, materials, or rooms are infected with fungi.

[0320] Agricultural chemical compositions contain a fungicide-effective amount of compound I. The term "fungicide-effective amount" refers to the amount of a composition or compound I sufficient to control harmful fungi on cultivated plants, or in the protection of stored products or harvests, or in the protection of materials, without causing substantial damage to the treated plants, stored products or harvests, or treated materials. This amount can vary widely and depends on various factors such as the fungal species to be controlled, the treated cultivated plants, stored products, harvests or materials, climatic conditions, and the specific compound I used.

[0321] Plant propagation material may be preventively treated with compound I itself or a composition containing at least one compound I during or before planting or transplanting.

[0322] When used for plant protection, the amount of active substance applied is 0.001 to 2 kg / ha, preferably 0.005 to 2 kg / ha, more preferably 0.05 to 0.9 kg / ha, and especially 0.1 to 0.75 kg / ha, depending on the type of effect desired.

[0323] In the treatment of plant propagation material (such as seeds), for example by dusting, coating or soaking, the amount of active substance required per 100 kg of plant propagation material (preferably seeds) is typically 0.1 to 1000 g, preferably 1 to 1000 g, more preferably 1 to 100 g and most preferably 5 to 100 g.

[0324] Users typically apply agricultural chemical compositions using pre-dose devices, backpack sprayers, spray cans, spray aircraft, or irrigation systems. Generally, the agricultural chemical composition is prepared to the desired application concentration using water, buffer solutions, and / or additional adjuvants, thus yielding a ready-to-use spray or agricultural chemical composition according to the invention. Typically, 20 to 2000 liters, preferably 50 to 400 liters, of ready-to-use spray are applied per hectare of usable agricultural area.

[0325] Compound I, its N-oxide, and salt can be converted into commonly used types of agrochemical compositions, such as solutions, emulsions, suspensions, dusts, powders, pastes, granules, tablets, capsules, and mixtures thereof. Examples of composition types (see also "Catalogue of pesticide formulation types and international coding system", Technical Monograph, Vol. 2, 6th edition, May 2008, CropLife International) are suspensions (e.g., SC, OD, FS), emulsifiable concentrates (e.g., EC), emulsions (e.g., EW, EO, ES, ME), capsules (e.g., CS, ZC), pastes, tablets, wettable powders or dusts (e.g., WP, SP, WS, DP, DS), tablets (e.g., BR, TB, DT), granules (e.g., WG, SG, GR, FG, GG, MG), insecticides (e.g., LN), and gel formulations (e.g., GF) for treating plant propagation materials (e.g., seeds). These compositions are prepared in known ways, such as those described in: Mollet and Grubemann, Formulation technology, Wiley VCH, Weinheim, 2001; or Knowles, New developments in crop protection product formulation, Agrow Reports DS243, T&F Informa, London, 2005. The present invention also relates to agrochemical compositions comprising an adjuvant and at least one compound I.

[0326] Suitable additives include solvents, liquid carriers, solid carriers or fillers, surfactants, dispersants, emulsifiers, wetting agents, auxiliary agents, solubilizers, penetration enhancers, protective colloids, adhesives, thickeners, humectants, repellents, attractants, feeding stimulants, compatibilizers, bactericides, antifreeze agents, antifoaming agents, colorants, viscous agents, and binders.

[0327] Suitable solvents and liquid carriers are water and organic solvents, such as medium to high boiling point mineral oil fractions, such as kerosene and diesel; oils of vegetable or animal origin; aliphatic, cyclic, and aromatic hydrocarbons, such as toluene, paraffin, tetrahydronaphthalene, and alkylnaphthalene; alcohols, such as ethanol, propanol, butanol, benzyl alcohol, cyclohexanol, and glycol; DMSO; ketones, such as cyclohexanone; esters, such as lactates, carbonates, fatty acid esters, and γ-butyrolactone; fatty acids; phosphonates; amines; amides, such as N-methylpyrrolidone and fatty acid dimethylamide; and mixtures thereof.

[0328] Suitable solid carriers or fillers are mineral soils, such as silicates, silica gel, talc, kaolin, limestone, lime, chalk, clay, dolomite, diatomaceous earth, bentonite, calcium sulfate, magnesium sulfate, and magnesium oxide; polysaccharides, such as cellulose and starch; fertilizers, such as ammonium sulfate, ammonium phosphate, ammonium nitrate, and urea; and plant-derived products, such as cereal flour, bark flour, wood flour, nut shell flour, and mixtures thereof.

[0329] Suitable surfactants are surface-active compounds, such as anionic, cationic, nonionic, and amphoteric surfactants, block polymers, polyelectrolytes, and mixtures thereof. Such surfactants can be used as emulsifiers, dispersants, solubilizers, wetting agents, penetration enhancers, protective colloids, or auxiliaries. Examples of surfactants are listed in McCutcheon's, Volume 1: Emulsifiers & Detergents, McCutcheon's Directories, Glen Rock, USA, 2008 (International or North American edition).

[0330] Suitable anionic surfactants are alkali metal salts, alkaline earth metal salts, or ammonium salts of sulfonates, sulfates, phosphates, and carboxylates, and mixtures thereof. Examples of sulfonates are alkylaryl sulfonates, diphenyl sulfonates, α-olefin sulfonates, lignin sulfonates, sulfonates of fatty acids and oils, sulfonates of ethoxylated alkylphenols, sulfonates of alkoxylated arylphenols, sulfonates of condensed naphthalenes, sulfonates of dodecylbenzene and tridecylbenzene, sulfonates of naphthalene and alkylnaphthalenes, sulfosuccinates, or sulfosuccinamates. Examples of sulfates are sulfates of fatty acids, oils, ethoxylated alkylphenols, alcohols, ethoxylated alcohols, or fatty acid esters. Examples of phosphates are phosphate esters. Examples of carboxylates are alkyl carboxylates and carboxylated alcohols or alkylphenol ethoxylates.

[0331] Suitable nonionic surfactants are alkoxylates, N-substituted fatty acid amides, amine oxides, esters, glycosyl surfactants, polymeric surfactants, and mixtures thereof. Examples of alkoxylates are compounds such as alcohols, alkylphenols, amines, amides, arylphenols, fatty acids, or fatty acid esters that have been alkoxylated by 1 to 50 equivalents. Ethylene oxide and / or propylene oxide can be used for alkoxylation, with ethylene oxide being preferred. Examples of N-substituted fatty acid amides are fatty acid glucosamides or fatty acid chain alkanolamides. Examples of esters are fatty acid esters, glycerides, or monoglycerides. Examples of glycosyl surfactants are sorbitan, ethoxylated sorbitan, sucrose and glucose esters, or alkyl polyglucosides. Examples of polymeric surfactants are homologs or copolymers of vinylpyrrolidone, vinyl alcohol, or vinyl acetate.

[0332] Suitable cationic surfactants are quaternary ammonium surfactants, such as quaternary ammonium compounds having one or two hydrophobic groups, or salts of long-chain primary amines. Suitable amphoteric surfactants are alkyl betaines and imidazolines. Suitable block polymers are AB or ABA type block polymers containing polyethylene oxide and polypropylene oxide blocks, or ABC type block polymers containing alkanols, polyethylene oxide, and polypropylene oxide. Suitable polyelectrolytes are polyacids or polybases. Examples of polyacids are alkali metal salts of polyacrylic acid or polyacid comb polymers. Examples of polybases are polyvinylamine or polyvinylamine.

[0333] Suitable adjuvants are compounds that possess negligible or no biocidal activity themselves and enhance the biological performance of compound I against the target. Examples include surfactants, mineral or vegetable oils, and other adjuvants, such as those listed in Knowles, Adjuvants and Additives, Agrow Reports DS256, T&F Informa UK, 2006, Chapter 5. Suitable thickeners are polysaccharides (e.g., xanthan gum, carboxymethyl cellulose), inorganic clays (organically modified or unmodified), polycarboxylates, and silicates. Suitable bactericides are bronopol and isothiazolinone derivatives, such as alkylisothiazolinones and benzisothiazolinones. Suitable antifreeze agents are ethylene glycol, propylene glycol, urea, and glycerin. Suitable defoamers are silicones, long-chain alcohols, and salts of fatty acids. Suitable colorants (e.g., red, blue, or green) are low-water-soluble pigments and water-soluble dyes. Examples include inorganic colorants (e.g., iron oxide, titanium dioxide, ferric hexacyanate ferrite) and organic colorants (e.g., alizarin, azo, and phthalocyanine colorants). Suitable thickeners or adhesives are polyvinylpyrrolidone, polyvinyl acetate, polyvinyl alcohol, polyacrylates, biowaxes or synthetic waxes, and cellulose ethers.

[0334] Agricultural chemical compositions typically contain, by weight, an active substance (e.g., at least one compound I) at a concentration between 0.01% and 95%, preferably between 0.1% and 90%, more preferably between 1% and 70%, and particularly between 10% and 60%. Agricultural chemical compositions typically contain, by weight, at least one adjuvant at a concentration between 5% and 99.9%, preferably between 10% and 99.9%, more preferably between 30% and 99%, and particularly between 40% and 90%. The active substance (e.g., compound I) is used with a purity of 90% to 100%, preferably 95% to 100% (based on NMR spectra).

[0335] For the purpose of treating plant propagating material, especially seeds, seed treatment solutions (LS), suspension emulsions (SE), flowable concentrates (FS), dry treatment powders (DS), water-dispersible powders (WS), water-soluble powders (SS), emulsions (ES), emulsifiable concentrates (EC), and gels (GF) are commonly used. After dilution two to ten times, the concentration of the active ingredient in the ready-to-use formulation of the compositions under discussion is 0.01% to 60% by weight, preferably 0.1% to 40%. Application can be carried out before or during sowing. Methods for applying compound I and its compositions to plant propagating material, especially seeds, include seed dressing, coating, granulation, dusting, soaking, and furrow application. Preferably, compound I or its compositions are applied to the plant propagating material by methods that do not induce germination, such as seed dressing, granulation, coating, and dusting.

[0336] Various types of oils, wetting agents, adjuvants, fertilizers, or micronutrients, as well as other pest control agents (e.g., fungicides, growth regulators, herbicides, insecticides, safeners) can be added as premixes to Compound I or its compositions, or added only before use (tank mix). These agents can be blended with the compositions according to the invention at a weight ratio of 1:100 to 100:1, preferably 1:10 to 10:1.

[0337] Pesticides are generally chemical or biological agents (such as pest-killing active ingredients, compounds, compositions, viruses, bacteria, antimicrobial agents, or disinfectants) that prevent, disable, kill, or otherwise thwart pests through their effects. Target pests can include insects, plant pathogens, weeds, mollusks, birds, mammals, fish, nematodes (roundworms), and microorganisms that damage property, cause disturbances, spread diseases, or act as vectors for diseases. The term "pesticide" also includes plant growth regulators that alter the expected growth, flowering, or reproductive rate of plants; defoliants that cause leaves or other foliage to fall off the plant, generally promoting harvest; desiccants that promote the drying of living tissues, such as unwanted above-ground parts of plants; plant activators that activate plant physiological functions to defend against certain pests; safeners that reduce the unwanted herbicidal effects of pesticides on crop plants; and plant growth promoters that affect plant physiological functions, such as enhancing plant growth, biomass, yield, or any other quality parameter of the harvestable product of the crop plant.

[0338] Biopesticides are defined as pesticides based on microorganisms (bacteria, fungi, viruses, nematodes, etc.) or natural products (compounds, such as metabolites, proteins, or extracts from biological or other natural sources) (US Environmental Protection Agency: http: / / www.epa.gov / pesticides / biopesticides / ). Biopesticides fall into two main categories: microbial and biochemical pesticides.

[0339] (1) Microbial pest control agents consist of bacteria, fungi, or viruses (and typically include metabolites produced by bacteria and fungi). Insecticidal nematodes are also classified as microbial pest control agents, although they are multicellular.

[0340] (2) Biochemical pesticides are naturally occurring substances that are relatively nontoxic to mammals, and are used to control pests or provide other crop protection purposes as defined below.

[0341] The total weight ratio of a composition containing at least one microbial pesticide in the form of live microbial cells (including dormant forms) can be determined by calculating the total weight of the corresponding active component using the following equation: 1 × 10⁻⁶ 10 CFU equals the total weight of one gram of the corresponding active ingredient. Colony forming unit is a measure of living microbial cells. Furthermore, in the case of nematode biocides such as Steinernema feltiae, "CFU" can also be understood as the number of (juvenile) individual nematodes.

[0342] In binary mixtures, the weight ratio of component 1) to component 2) generally depends on the properties of the components used, typically in the range of 1:10,000 to 10,000:1, often in the range of 1:100 to 100:1, frequently in the range of 1:50 to 50:1, preferably in the range of 1:20 to 20:1, more preferably in the range of 1:10 to 10:1, even more preferably in the range of 1:4 to 4:1, and particularly in the range of 1:2 to 2:1. According to another embodiment, the weight ratio of component 1) to component 2) is generally from 1000:1 to 1:1, often from 100:1 to 1:1, frequently from 50:1 to 1:1, preferably from 20:1 to 1:1, more preferably from 10:1 to 1:1, even more preferably from 4:1 to 1:1, and particularly in the range of 2:1 to 1:1. According to another embodiment, the weight ratio of component 1) to component 2) is typically from 20,000:1 to 1:10, often from 10,000:1 to 1:1, frequently from 5,000:1 to 5:1, preferably from 5,000:1 to 10:1, more preferably from 2,000:1 to 30:1, even more preferably from 2,000:1 to 100:1, and particularly in the range of 1,000:1 to 100:1. According to another embodiment, the weight ratio of component 1) to component 2) is typically from 1:1 to 1:1000, often from 1:1 to 1:100, frequently from 1:1 to 1:50, preferably from 1:1 to 1:20, more preferably from 1:1 to 1:10, even more preferably from 1:1 to 1:4, and particularly in the range of 1:1 to 1:2. According to another embodiment, the weight ratio of component 1) to component 2) is typically from 10:1 to 1:20,000, often from 1:1 to 1:10,000, frequently from 1:5 to 1:5,000, preferably from 1:10 to 1:5,000, more preferably from 1:30 to 1:2,000, even more preferably from 1:100 to 1:2,000, and particularly in the range of 1:100 to 1:1,000.

[0343] In a ternary mixture, i.e., a composition comprising component 1), component 2), and compound III (component 3), the weight ratio of component 1) to component 2) depends on the characteristics of the active substance used, and is typically in the range of 1:100 to 100:1, often in the range of 1:50 to 50:1, preferably in the range of 1:20 to 20:1, more preferably in the range of 1:10 to 10:1, and particularly in the range of 1:4 to 4:1, and the weight ratio of component 1) to component 3) is typically in the range of 1:100 to 100:1, often in the range of 1:50 to 50:1, preferably in the range of 1:20 to 20:1, more preferably in the range of 1:10 to 10:1, and particularly in the range of 1:4 to 4:1. If necessary, any additional active ingredients may be added to component 1) at a ratio of 20:1 to 1:20. These ratios are also suitable for mixtures applied via seed treatment.

[0344] When mixtures containing microbial pesticides are used for crop protection, the application rate range is 1 × 10⁻⁶. 6 Up to 5 × 10 16 (or greater) CFU / ha, preferably 1 × 10 8 Up to 1 × 10 13 CFU / ha, and even more preferably 1 × 10 9 Up to 5 × 10 15 CFU / ha, and especially 1 × 10 12 Up to 5 × 10 14 CFU / ha. When nematodes are used as microbial pest control agents (e.g., *Nocturia stearothermia*), the application rate often ranges from 1 × 10⁻⁶. 5 Up to 1 × 10 12 (or larger), preferably 1 × 10 8 Up to 1 × 10 11 More preferably 5 × 10 8 Up to 1 × 10 10 Individual (e.g., in the form of egg, larva or any other living stage, preferably in the infetive larval stage) / ha.

[0345] When mixtures containing microbial pesticides are used for seed treatment, the application rate typically ranges from 1 × 10⁻⁶. 6 Up to 1 × 10 12 (or larger) CFU / seed, preferably 1 × 10 6 Up to 1 × 10 9 CFU / seed. Furthermore, the application rate for seed treatment is typically in the range of 1 × 10⁻⁶. 7Up to 1 × 10 14 (or larger) CFU / 100 kg seeds, preferably 1 × 10 9 Up to 1× 10 12 CFU / 100 kg of seeds.

[0346] Biopesticides from groups L1) and / or L2) may also possess insecticidal, acaricidal, molluscicidal, pheromone-based, nematicidal, plant stress-reducing, plant growth-regulating, plant growth-promoting, and / or yield-enhancing activities. Biopesticides from groups L3) and / or L4) may also possess fungicidal, bactericidal, virucidal, plant defense activator, plant stress-reducing, plant growth-regulating, plant growth-promoting, and / or yield-enhancing activities. Biopesticides from group L5) may also possess fungicidal, bactericidal, virucidal, plant defense activator, insecticidal, acaricidal, molluscicidal, pheromone-based, and / or nematicidal activities.

[0347] Microbial agents that kill pests, particularly those from groups L1), L3), and L5), include not only pure cultures of the corresponding microorganisms as defined herein, but also cell-free extracts thereof, suspensions thereof in whole broth cultures and metabolite-containing media, or purified metabolites obtained from whole broth cultures of microorganisms.

[0348] Many of these biocides are deposited using the accession numbers mentioned in this article (prefixes such as ATCC or DSM refer to the acronyms for the corresponding culture deposits; see here for details, for example: http: / / www.wfcc.info / ccinfo / collection / by_acronym / The following strains are mentioned in the literature, registered and / or commercially available: a mixture of *Brucea buddinga* DSM14940 and DSM 14941 isolated in Constance, Germany in 1989 (e.g., budding spores, from bio-ferm GmbH, Austria, BlossomProtect®); *Azotoxinus brasiliensis* Sp245 originally isolated in the wheat region of southern Brazil (Pazufontu) at least before 1980 (BR 11005; e.g., from BASF Agricultural Specialties Ltd., Brazil, GELFIX® Gramíneas); *Azotoxinus brasiliensis* strains Ab-V5 and Ab-V6 (e.g., from Novozymes BioAg Produtos papra Agricultura Ltda., Quattro Barras, Brazil). AzoMax from Brazil or Simbiose-Maíz® from Simbiose-Agro, Brazil; Plant Soil 331, 413-425, 2010), Bacillus amyloliquefaciens strain AP-188 (NRRL B-50615 and B-50331; US ​​8,445,255); Bacillus amyloliquefaciens subsp. plantarum strain, formerly sometimes referred to as Bacillus subtilis, recently classified as Bacillus berleisei along with B. methylotrophicus and Bacillus berleisei (Int. J. Syst. Evol. Microbiol. [International Journal of Systematic and Evolutionary Microbiology] 66, 1212-1217, 2016): Bacillus amyloliquefaciens subsp. plantarum or Bacillus berleisei D747 (US 20130236522) isolated from the air in Kikukawa City, Japan. A1; FERM BP-8234; e.g., Double Nickel™ 55 WDG from Certis LLC, USA), *Bacillus amyloliquefaciens* subsp. *plantae* or *Bacillus belyes* FZB24 (also known as SB3615; DSM 96-2; J. Plant Dis. Prot. [Journal of Plant Diseases and Control] 105, 181-197, 1998; e.g., Taegro® from Novozyme Biologicals, Inc., USA), *Bacillus amyloliquefaciens* subsp. *plantae* or *Bacillus belyes* FZB42 (DSM 23117; J. Plant Dis. Prot.) isolated from soil in Brandenburg, Germany.[Journal of Plant Diseases and Control] 105, 181-197, 1998; e.g., RhizoVital® 42 from AbiTEP GmbH, Germany), *Bacillus plantarum* subsp. *amylloides* or *Bacillus belysium* MBI600 (also known as 1430; NRRL B-50595; US 2012 / 0149571 A1; e.g., Integral® from BASF Corp., USA), *Bacillus plantarum* subsp. *amylloides* or *Bacillus belysium* QST-713 (NRRL B-21661; e.g., Serenade® MAX from Bayer Crop Science LP, USA), *Bacillus plantarum* or *Bacillus belysium* QST-713 (NRRL B-21661; e.g., Serenade® MAX from Bayer Crop Science LP, USA), *Bacillus plantarum*, *Bacillus belysium ... *Bacillus amyloliquefaciens* subsp. *plantae* or *Bacillus belesii* TJ1000 (also known as 1BE; ATCC BAA-390; CA 2471555 A1; e.g., QuickRoots™ from TJ Technologies, Watertown, SD, USA, USA); *Bacillus sturdier* CNCM I-1582, a variant of parent strain EIP-N1 isolated from soil in the Central Plains of Israel (CNCM I-1556) (WO 2009 / 126473, US 6,406,690; e.g., Votivo® from Bayer Crop Science, LLC, USA); *Bacillus pumilus* GHA180 isolated from the rhizosphere of apple trees in Mexico (IDAC 260707-01; e.g., PRO-MIX® from Premier Horticulture, Quebec, Canada, Canada). B. pumilus INR-7, also known as BU-F22 and BU-F33, was isolated from cucumbers infected with Erwinia tracheiphila (NRRL B-50185, NRRL B-50153; US 8,445,255) at least before 1993. B. pumilus KFP9F was isolated from the rhizosphere of grasses in South Africa at least before 2008 (NRRL B-50754; WO 2014 / 029697; for example, from BASF Agricultural Specialities (Pty) Ltd., South Africa).Bac-UP or FUSION-P from South Africa), Bacillus pumilus QST 2808 was isolated in 1998 from soil collected in Pohnpei, Federated States of Micronesia (NRRL B-30087; e.g., Sonata® or Ballad® Plus from Bayer Crop Science LLC), Bacillus simplex ABU 288 (NRRL B-50304; US 8,445,255), also known as UD 1022 or UD10-22, and Bacillus subtilis FB17 were isolated from red beet roots in North America (ATCC PTA-11857; System. Appl. Microbiol. [Systems and Applied Microbiology] 27, 372-379, 2004; US 2010 / 0260735; WO 2011 / 109395); Bacillus thuringiensis subsp. tsuriae ABTS-1857 was isolated in 1987 from soil taken from Ephraim lawns in Wisconsin, USA (also known as ABG-6346; ATCC SD-1372; e.g., XenTari® from BioFa AG, Münsingen, Germany); Bacillus thuringiensis subsp. kurstak ABTS-351 is equivalent to HD-1 isolated in 1967 from diseased bollworm larvae in Brownsville, Texas, USA (ATCC SD-1275; e.g., Dipel® DF from Valent BioSciences, IL, USA); Bacillus thuringiensis subsp. kurstak SB4 was isolated from the cadavers of African stem borer (E. saccharina) larvae (NRRL). B-50753; e.g., Beta Pro® from BASF Agriproducts Ltd., South Africa), Bacillus thuringiensis subsp. *Bacillus* NB-176-1, a mutant of strain NB-125, a wild-type strain isolated in 1982 from the dead pupae of the mealworm (DSM 5480; EP 585 215 B1; e.g., Novodor® from ValentBioSciences, Switzerland), Beauveria bassiana GHA (ATCC 74250; e.g., BotaniGard® 22WGP from Laverlam Int. Corp., USA), Beauveria bassiana JW-1 (ATCC 74040; e.g., CBC (Europe) Srl.Naturalis® (Italy), Beauveria bassiana PPRI 5339 was isolated from the larvae of the tortoise beetle Conchyloctenia punctata (NRRL 50757; e.g. BroadBand® from BASF Agricultural Specialties Ltd., South Africa), SEMIA 5019 (also known as 29W) strain of SEMIA 587 was isolated in Rio de Janeiro, Brazil and in 1967 in the State of Rio Grande do Sul, from areas previously inoculated with North American isolates and used as commercial inoculum since 1968 (Appl. Environ. Microbiol. [Applied and Environmental Microbiology] 73(8), 2635, 2007; e.g. GELFIX 5 from BASF Agricultural Specialties Ltd., Brazil), and Soybean Slow Rhizobium 532c was isolated from a field in Wisconsin, USA (Nitragin 61A152; Can. J.). Plant. Sci. [Canadian Journal of Plant Science] 70, 661-666, 1990; e.g., Rhizoflo®, Histick®, Hicoat® Super from BASF Agricultural Specialties Ltd., Canada), strain USDA 138 of soybean slow-growing rhizobium E-109 variant (INTA E109, SEMIA 5085; Eur. J. Soil Biol. [European Journal of Soil Biology] 45, 28-35, 2009; Biol. Fertil. Soils [Soil Biology and Fertility] 47, 81-89, 2011); by Appl. Environ. Microbiol.[Applied and Environmental Microbiology] 73(8), 2635, 2007 Known soybean slow-growing rhizobium strains preserved in SEMIA: SEMIA 5079 was isolated from soil by the Brazilian Institute of Agricultural Research in Cerrados (Embrapa-Cerrados) in the Cerrados region of Brazil and has been used as a commercial inoculum since 1992 (CPAC 15; e.g., GELFIX 5 or ADHERE 60 from BASF Agroproducts, Brazil); SEMIA 5080, a soybean slow-growing rhizobium obtained in Brazil by Embrapa-Cerrados under laboratory conditions and has been used as a commercial inoculum since 1992, is a natural variant (CB1809) of SEMIA 586 originally isolated in the United States (CPAC 7; e.g., GELFIX 5 or ADHERE from BASF Agroproducts, Brazil). 60); Burkholderia species A396 was isolated from soil in Nikko, Japan in 2008 (NRRLB-50319; WO 2013 / 032693; Marrone Bio Innovations, Inc., USA); Shield-shaped mold CON / M / 91-08 was isolated from rapeseed (WO 1996 / 021358; DSM 9660; e.g., Contans® WG, Intercept® WG from Bayer CropScience AG, Germany); hypersensitive protein (α-β) protein (Science 257, 85-88, 1992; e.g., Messenger™ or HARP-N-Tek from PlantHealth Care plc, UK); HearNPV (J. Invertebrate Pathol. 107, 2008). 112-126, 2011; for example, Helicovex® from Adermatt Biocontrol, Switzerland; Diplomata® from Koppert, Brazil; and AgBiTech Pty Ltd from Queensland, Australia.Vivus® Max from Queensland, Australia), corn noctuid moth monocotyledon nucleopolyhedrovirus (HzSNPV) (e.g., Gemstar® from Cernan LLC, USA), corn noctuid moth nucleopolyhedrovirus ABA-NPV-U (e.g., Heligen® from AgroBiotech Ltd, Queensland, Australia), Hemibarbus hygrophilus (e.g., Nemasys® G from BASF Agricultural Specialities Limited, UK), Apopka-97 of *Metasequoia glyptostroboides* isolated from mealybugs on *Apis purpurea* in Apopka, Florida, USA (ATCC 20874; Biocontrol Science Technol. [Biological Control Science and Technology] 22(7), 747-761, 2012; e.g., PFR-97™ or PreFeRal® from Cernan LLC, USA), also known as 275 or V275, *Metarhizium anisopliae* microsporum variant F52 isolated from codling moth in Austria (DSM) 3884, ATCC90448; e.g., Met52®, Novozymes BiologicalsBioAg Group, Canada); *Megasteria burmannii* 277 isolated from grapes in central Israel (US 6,994,849; NRRL Y-30752; e.g., previously from Agrogreen Israel's Shemer®); *Paecilomyces lilacinus* 251 isolated from infected nematode eggs in the Philippines (AGAL 89 / 030550; WO 1991 / 02051; Crop Protection 27, 352-361, 2008; e.g., from Bayer Crop Science AG's BioAct® and from CeraCon®, USA); *Bacillus nasus* NAS6G6 isolated from grass rhizosphere in South Africa at least before 2008 (WO2014 / 029697; NRRL). B-50755; for example, from BASF Agricultural Specialities (Pty) Ltd., South Africa.Bacillus strains isolated from soil samples from various European regions, including Germany (BAC-UP): Epiphytic Bacillus Lu17015 (WO 2016 / 020371; DSM 26971), Polymyxin Bacillus plantarum Lu16774 (WO 2016 / 020371; DSM 26969), Polymyxin Bacillus plantarum strain Lu17007 (WO2016 / 020371; DSM 26970); Pasteurella multocida Pn1 was isolated from a soybean field in Illinois, USA in the mid-2000s (ATCC SD-5833; Federal Register [Federal Register] 76(22), 5808, February 2, 2011; Clariva™ PN from Syngenta Crop Protection, LLC, for example, Penicillium baicalensis (also known as P. baicalensis). The strains *Bilaii* ATCC 18309 (= ATCC 74319), ATCC 20851, and / or ATCC22348 (= ATCC 74318) were originally isolated from soil in Alberta, Canada (Fertilizer Research, 39, 97-103, 1994; Can.J. Plant Sci., 78(1), 91-102, 1998; US 5,026,417, WO 1995 / 017806; e.g. Jump Start®, Provide® from Novozymes BioAgriculture Group, Canada), Polygonum cuspidatum extract (EP 0307510 B1; e.g. Regalia® from Marrone BioInnovations, Davis, CA, USA). Milsana® (SC or from Bayer AG, Germany), Small leafroller nematode (e.g., Millenium® from BASF Agriproducts Ltd., UK), and Noctuida spp. nematode (e.g., from BioWorks, Inc., USA).Nemashield® (from BASF Agriproducts Ltd., USA); Nemasys® (from BASF Agriproducts Ltd., UK); *Streptomyces flavus* NRRL B-50550 (WO 2014 / 124369; Bayer Crop Science, Germany); *Trichoderma hygroscopicum* JM41R isolated in South Africa (NRRL 50759; also known as *Trichoderma apicals*; e.g., Trichoplus® from BASF Agriproducts Ltd., South Africa); *Trichoderma harzianum* T-22 also known as KRL-AG2 (ATCC 20847; BioControl [Biological Control] 57, 687-696, 2012; e.g., Plantshield® from American Bioengineering Company or SabrEx™ from Advanced Biological Marketing Inc., VanWert, OH, USA).

[0349] The processing method according to the invention can also be used in areas where stored products or harvested goods are protected from fungal and microbial invasion. According to the invention, the term "stored product" should be understood to refer to natural substances of plant or animal origin and their processed forms, which are derived from their natural life cycle and are desired to be protected for a long period. Stored products of crop plant origin (such as plants or parts thereof), such as stems, leaves, tubers, seeds, fruits, or grains, can be protected either in their freshly harvested state or through processed forms such as pre-drying, wetting, crushing, grinding, pressing, or baking (processing is also known as post-harvest treatment). Also falling under the definition of stored products is timber, whether in log form, such as construction timber, transmission towers, and fences, or in finished product form, such as furniture or objects made of wood. Stored products of animal origin are hides, leather, fur, hair, etc. The combination according to the invention can prevent adverse effects such as rot, discoloration, or mold. Preferably, “stored products” should be understood as natural substances of plant origin and their processed forms, more preferably fruits and their processed forms, such as pome, stone fruit, soft fruit and citrus fruits and their processed forms.

[0350] Compounds having formula I can exist in different crystal forms with varying biological activities. They are also the subject of this invention.

[0351] Compound I is used as is or in combination form by treating fungi or plants, plant propagation materials (such as seeds), soil, surfaces, materials, or rooms to be protected from fungal infection with an effective amount of the active substance. Application can be carried out before and after the plants, plant propagation materials (such as seeds), soil, surfaces, materials, or rooms are infected with fungi.

[0352] Plant propagation material may be preventively treated with compound I itself or a composition containing at least one compound I during or before planting or transplanting.

[0353] The present invention also relates to an agricultural chemical composition comprising an adjuvant and at least one compound I according to the present invention.

[0354] Agricultural chemical compositions contain a fungicide-effective amount of compound I. The term "effective amount" refers to the amount of composition or compound I sufficient to control harmful fungi or protective materials on cultivated plants without causing substantial damage to the treated plants. This amount can vary widely and depends on various factors such as the fungal species to be controlled, the cultivated plants or materials being treated, climatic conditions, and the specific compound I used.

[0355] Compound I, its N-oxide, and salt can be converted into commonly used types of agrochemical compositions, such as solutions, emulsions, suspensions, dusts, powders, pastes, granules, tablets, capsules, and mixtures thereof. Examples of composition types include suspensions (e.g., SC, OD, FS), emulsifiable concentrates (e.g., EC), emulsions (e.g., EW, EO, ES, ME), capsules (e.g., CS, ZC), pastes, tablets, wettable powders or dusts (e.g., WP, SP, WS, DP, DS), tablets (e.g., BR, TB, DT), granules (e.g., WG, SG, GR, FG, GG, MG), insecticides (e.g., LN), and gel formulations for treating plant propagation materials such as seeds (e.g., GF). These and other composition types are defined in “Catalogue of pesticide formulation types and international coding system”, Technical Monograph, Vol. 2, 6th edition, May 2008, CropLife International.

[0356] These compositions are prepared in known ways, such as those described in: Mollet and Grubemann, Formulation technology, Wiley VCH, Weinheim, 2001; or Knowles, New developments in crop protection product formulation, Agrow Reports DS243, T&F Informa, London, 2005.

[0357] The binary or ternary mixtures of the active compounds described herein can be prepared by conventional means, such as those given herein for the composition containing compound I, into a composition comprising at least one inert component (adjuvant) in addition to the active ingredient. For the general composition of such compositions, refer to the explanation given for the composition containing compound I.

[0358] Suitable additives include solvents, liquid carriers, solid carriers or fillers, surfactants, dispersants, emulsifiers, wetting agents, auxiliary agents, solubilizers, penetration enhancers, protective colloids, adhesives, thickeners, humectants, repellents, attractants, feeding stimulants, compatibilizers, bactericides, antifreeze agents, defoamers, colorants, viscous agents, and adhesives.

[0359] Suitable solvents and liquid carriers are water and organic solvents, such as medium to high boiling point mineral oil fractions, such as kerosene and diesel; oils of vegetable or animal origin; aliphatic, cyclic, and aromatic hydrocarbons, such as toluene, paraffin, tetrahydronaphthalene, and alkylnaphthalene; alcohols, such as ethanol, propanol, butanol, benzyl alcohol, and cyclohexanol; glycols; DMSO; ketones, such as cyclohexanone; esters, such as lactates, carbonates, fatty acid esters, and γ-butyrolactone; fatty acids; phosphonates; amines; amides, such as N-methylpyrrolidone and fatty acid dimethylamide; and mixtures thereof.

[0360] Suitable solid carriers or fillers are mineral soils, such as silicates, silica gel, talc, kaolin, limestone, lime, chalk, clay, dolomite, diatomaceous earth, bentonite, calcium sulfate, magnesium sulfate, and magnesium oxide; polysaccharides, such as cellulose and starch; fertilizers, such as ammonium sulfate, ammonium phosphate, ammonium nitrate, and urea; and plant-derived products, such as cereal flour, bark flour, wood flour, nut shell flour, and mixtures thereof.

[0361] Suitable surfactants are surface-active compounds, such as anionic, cationic, nonionic, and amphoteric surfactants, block polymers, polyelectrolytes, and mixtures thereof. Such surfactants can be used as emulsifiers, dispersants, solubilizers, wetting agents, penetration enhancers, protective colloids, or auxiliaries. Examples of surfactants are listed in McCutcheon's, Volume 1: Emulsifiers & Detergents, McCutcheon's Directories, Glen Rock, USA, 2008 (International or North American edition).

[0362] Suitable anionic surfactants are alkali metal salts, alkaline earth metal salts, or ammonium salts of sulfonates, sulfates, phosphates, and carboxylates, and mixtures thereof. Examples of sulfonates are alkylaryl sulfonates, diphenyl sulfonates, α-olefin sulfonates, lignin sulfonates, sulfonates of fatty acids and oils, sulfonates of ethoxylated alkylphenols, sulfonates of alkoxylated arylphenols, sulfonates of condensed naphthalenes, sulfonates of dodecylbenzene and tridecylbenzene, sulfonates of naphthalene and alkylnaphthalenes, sulfosuccinates, or sulfosuccinamates. Examples of sulfates are sulfates of fatty acids and oils, sulfates of ethoxylated alkylphenols, sulfates of alcohols, sulfates of ethoxylated alcohols, or sulfates of fatty acid esters. Examples of phosphates are phosphate esters. Examples of carboxylates are alkyl carboxylates and carboxylated alcohols or alkylphenol ethoxylates.

[0363] Suitable nonionic surfactants are alkoxylates, N-substituted fatty acid amides, amine oxides, esters, glycosyl surfactants, polymeric surfactants, and mixtures thereof. Examples of alkoxylates are compounds such as alcohols, alkylphenols, amines, amides, arylphenols, fatty acids, or fatty acid esters that have been alkoxylated by 1 to 50 equivalents. Ethylene oxide and / or propylene oxide can be used for alkoxylation, with ethylene oxide being preferred. Examples of N-substituted fatty acid amides are fatty acid glucosamides or fatty acid chain alkanolamides. Examples of esters are fatty acid esters, glycerides, or monoglycerides. Examples of glycosyl surfactants are sorbitol, ethoxylated sorbitol, sucrose and glucose esters, or alkyl polyglucosides. Examples of polymeric surfactants are homologs or copolymers of vinylpyrrolidone, vinyl alcohol, or vinyl acetate.

[0364] Suitable cationic surfactants are quaternary ammonium surfactants, such as quaternary ammonium compounds having one or two hydrophobic groups, or salts of long-chain primary amines. Suitable amphoteric surfactants are alkyl betaines and imidazolines. Suitable block polymers are AB or ABA type block polymers containing blocks of polyethylene oxide and polypropylene oxide, or ABC type block polymers containing alkanols, polyethylene oxide, and polypropylene oxide. Suitable polyelectrolytes are polyacids or polybases. Examples of polyacids are alkali metal salts of polyacrylic acid or polyacid comb polymers. Examples of polybases are polyvinylamine or polyvinylamine.

[0365] Suitable adjuvants are compounds that possess negligible or no biocidal activity themselves, and which enhance the biological performance of compound I against the target. Examples include surfactants, mineral or vegetable oils, and other adjuvants. Further examples are listed in Knowles, Adjuvants and Additives, Agrow Reports DS256, T&F Informa UK, 2006, Chapter 5.

[0366] Suitable thickeners are polysaccharides (such as xanthan gum and carboxymethyl cellulose), inorganic clays (organically modified or unmodified), polycarboxylates, and silicates.

[0367] Suitable bactericides are bromonitol and isothiazolinone derivatives, such as alkylisothiazolinone and benzisothiazolinone.

[0368] Suitable antifreeze agents are ethylene glycol, propylene glycol, urea, and glycerin.

[0369] Suitable defoamers are salts of silicones, long-chain alcohols, and fatty acids.

[0370] Suitable colorants (e.g., red, blue, or green) are low-water-soluble pigments and water-soluble dyes. Examples are inorganic colorants (e.g., iron oxide, titanium oxide, ferric hexacyanate ferrite) and organic colorants (e.g., alizarin, azo, and phthalocyanine colorants).

[0371] Suitable tackifiers or adhesives are polyvinylpyrrolidone, polyvinyl acetate, polyvinyl alcohol, polyacrylate, biowax or synthetic wax, and cellulose ether.

[0372] Examples of composition types and their preparation are:

[0373] i) Water-soluble concentrates (SL, LS)

[0374] Dissolve 10-60 wt% of Compound I and 5-15 wt% of a wetting agent (e.g., an alcohol alkoxylate) in water and / or a water-soluble solvent (e.g., an alcohol) added to 100 wt%. The active compound dissolves upon dilution with water.

[0375] ii) Dispersible concentrate (DC)

[0376] Dissolve 5-25 wt% of compound I and 1-10 wt% of a dispersant (e.g., polyvinylpyrrolidone) in an organic solvent (e.g., cyclohexanone) added up to 100 wt%. Dilute with water to obtain the dispersion.

[0377] iii) Emulsifiable concentrate (EC)

[0378] 15-70 wt% of compound I and 5-10 wt% of emulsifier (e.g., calcium dodecylbenzenesulfonate and castor oil ethoxylate) are dissolved in a water-insoluble organic solvent (e.g., an aromatic hydrocarbon) added to 100 wt%. The emulsion is then diluted with water.

[0379] iv) Emulsions (EW, EO, ES)

[0380] 5-40 wt% of compound I and 1-10 wt% of emulsifier (e.g., calcium dodecylbenzenesulfonate and castor oil ethoxylate) are dissolved in 20-40 wt% of a water-insoluble organic solvent (e.g., an aromatic hydrocarbon). This mixture is introduced into 100 wt% water using an emulsifier to form a homogeneous emulsion. The emulsion is then diluted with water.

[0381] v) Suspension (SC, OD, FS)

[0382] In a stirred ball mill, 20-60 wt% of Compound I is pulverized with the addition of 2-10 wt% of a dispersant and wetting agent (e.g., sodium lignosulfonate and alcohol ethoxylate), 0.1-2 wt% of a thickener (e.g., xanthan gum), and water up to 100 wt% to obtain a fine suspension of the active compound. The suspension is then diluted with water to obtain a stable suspension of the active substance. For FS-type compositions, up to 40 wt% of a binder (e.g., polyvinyl alcohol) is added.

[0383] vi) Water-dispersible granules and water-soluble granules (WG, SG)

[0384] Compound I (50-80 wt%) is finely ground with up to 100 wt% of dispersant and wetting agent (e.g., sodium lignosulfonate and alcohol ethoxylate) and prepared into water-dispersible or water-soluble granules using technological devices (e.g., extrusion, spray tower, fluidized bed). Diluting with water yields a stable dispersion or solution of the active substance.

[0385] vii) Water-dispersible powders and water-soluble powders (WP, SP, WS)

[0386] Compound I (50-80 wt%) was milled in a rotor-stator mill with the addition of 1-5 wt% dispersant (e.g., sodium lignosulfonate), 1-3 wt% wetting agent (e.g., alcohol ethoxylate), and up to 100 wt% solid support (e.g., silica gel). The mixture was then diluted with water to obtain a stable dispersion or solution of the active substance.

[0387] viii) Gel (GW, GF)

[0388] In a stirred ball mill, 5-25 wt% of compound I is pulverized with the addition of 3-10 wt% of a dispersant (e.g., sodium lignosulfonate), 1-5 wt% of a thickener (e.g., carboxymethyl cellulose), and water up to 100 wt% to obtain a fine active substance suspension. The suspension is then diluted with water to obtain a stable active substance suspension.

[0389] ix) Microemulsion (ME)

[0390] Add 5-20 wt% of Compound I to 5-30 wt% of an organic solvent blend (e.g., fatty acid dimethylamide and cyclohexanone), 10-25 wt% of a surfactant blend (e.g., alcohol ethoxylates and arylphenol ethoxylates), and to 100 wt% of water. Stir this mixture for 1 h to spontaneously generate a thermodynamically stable microemulsion.

[0391] x) Microcapsules (CS)

[0392] An oil phase comprising 5-50 wt% of Compound I, 0-40 wt% of a water-insoluble organic solvent (e.g., aromatic hydrocarbons), and 2-15 wt% of an acrylic monomer (e.g., methyl methacrylate, methacrylic acid, and diacrylate or triacrylate) is dispersed in an aqueous solution of a protective colloid (e.g., polyvinyl alcohol). Free radical polymerization results in the formation of poly(meth)acrylate microcapsules. Alternatively, an oil phase comprising 5-50 wt% of Compound I according to the invention, 0-40 wt% of a water-insoluble organic solvent (e.g., aromatic hydrocarbons), and an isocyanate monomer (e.g., diphenylmethylene-4,4'-diisocyanate) is dispersed in an aqueous solution of a protective colloid (e.g., polyvinyl alcohol). The addition of a polyamine (e.g., hexamethylenediamine) results in the formation of polyurea microcapsules. The monomer amount is 1-10 wt%. wt% is related to the total CS composition.

[0393] xi) Dustable powders (DP, DS)

[0394] 1-10 wt% of compound I is finely ground and thoroughly mixed with up to 100 wt% of a solid support (e.g., finely dispersed kaolin).

[0395] xii) Granules (GR, FG)

[0396] Compound I (0.5–30 wt%) is finely ground and combined with a solid support (e.g., silicate) added up to 100 wt%. Granulation is achieved by extrusion, spray drying, or fluidized bed.

[0397] xiii) Ultra-low volume liquids (UL)

[0398] Dissolve 1-50 wt% of compound I in an organic solvent (e.g., an aromatic hydrocarbon) added up to 100 wt%.

[0399] Composition types i) to xiii) may optionally contain additional adjuvants, such as 0.1-1 wt% bactericide, 5-15 wt% antifreeze, 0.1-1 wt% defoamer, and 0.1-1 wt% colorant.

[0400] Agricultural chemical compositions typically contain between 0.01% and 95% by weight, preferably between 0.1% and 90%, more preferably between 1% and 70%, and particularly between 10% and 60% of an active substance. The active substance is used with a purity of 90% to 100%, preferably 95% to 100% (based on NMR spectra).

[0401] For the purpose of treating plant propagating material, especially seeds, seed treatment solutions (LS), suspension emulsions (SE), flowable concentrates (FS), dry treatment powders (DS), water-dispersible powders (WS), water-soluble powders (SS), emulsions (ES), emulsifiable concentrates (EC), and gels (GF) are commonly used. After dilution two to ten times, the concentration of the active compound in the ready-to-use formulation of the compositions under discussion is 0.01% to 60% by weight, preferably 0.1% to 40%. Application can be carried out before or during sowing. Methods for applying compound I and its compositions to plant propagating material, especially seeds, include seed dressing, coating, granulation, dusting, soaking, and furrow application. Preferably, compound I or its compositions are applied to the plant propagating material by methods that do not induce germination, such as seed dressing, granulation, coating, and dusting.

[0402] When used for plant protection, the amount of active substance applied is 0.001 to 2 kg / ha, preferably 0.005 to 2 kg / ha, more preferably 0.05 to 0.9 kg / ha, and especially 0.1 to 0.75 kg / ha, depending on the type of effect desired.

[0403] In the treatment of plant propagation material such as seeds, for example by dusting, coating or soaking, the amount of active compound is typically required for every 100 kg of plant propagation material (preferably seeds), ranging from 0.1 to 1000 g, preferably 1 to 1000 g, more preferably 1 to 100 g, and most preferably 5 to 100 g.

[0404] When used for the protection of materials or stored products, the amount of active compound applied depends on the type of application and the desired effect. Typically, the amount applied for the protection of materials is 0.001 g to 2 kg, preferably 0.005 g to 1 kg of active compound per cubic meter of treated material.

[0405] Various types of oils, wetting agents, adjuvants, fertilizers, or micronutrients and other pest control agents (e.g., herbicides, insecticides, fungicides, growth regulators, safeners, biopesticides) can be added as premixes to the active substance or the composition containing it, or, if appropriate, only to be added immediately before use (bucket mixing). These agents can be blended with the composition according to the invention at a weight ratio of 1:100 to 100:1, preferably 1:10 to 10:1.

[0406] Pesticides are generally chemical or biological agents (such as pest-killing active ingredients, compounds, compositions, viruses, bacteria, antimicrobial agents, or disinfectants) that prevent, disable, kill, or otherwise thwart pests through their effects. Target pests can include insects, plant pathogens, weeds, mollusks, birds, mammals, fish, nematodes (roundworms), and microorganisms that damage property, cause disturbances, spread diseases, or act as vectors for diseases. The term "pesticide" also includes plant growth regulators that alter the expected growth, flowering, or reproductive rate of plants; defoliants that cause leaves or other foliage to fall off the plant, generally promoting harvest; desiccants that promote the drying of living tissues, such as unwanted above-ground parts of plants; plant activators that activate plant physiological functions to defend against certain pests; safeners that reduce the unwanted herbicidal effects of pesticides on crop plants; and plant growth promoters that affect plant physiological functions, such as enhancing plant growth, biomass, yield, or any other quality parameter of the harvestable product of the crop plant.

[0407] Users typically apply the compositions according to the invention via pre-dose devices, backpack sprayers, spray cans, spray aircraft, or irrigation systems. Generally, the agricultural chemical composition is prepared to the desired application concentration with water, buffer solutions, and / or additional adjuvants, thus obtaining the ready-to-use spray or agricultural chemical composition according to the invention. Typically, 20 to 2000 liters, preferably 50 to 400 liters, of ready-to-use spray are applied per hectare of usable agricultural area.

[0408] According to one embodiment, the individual components of the composition according to the invention, such as portions of the kit or portions of a binary or ternary mixture, can be mixed by the user himself in a spray can or any other type of container for application (e.g., seed processor drum, seed granulator, backpack sprayer), and additional adjuvants may be added where appropriate.

[0409] Therefore, one embodiment of the present invention is a kit for preparing a usable biocidal composition comprising a) a composition comprising component 1) as defined herein and at least one adjuvant; and b) a composition comprising component 2) as defined herein and at least one adjuvant; and optionally c) a composition comprising at least one adjuvant and optionally another active component 3) as defined herein.

[0410] In many cases, mixing compound I, or a composition containing it, as a fungicide with other fungicides results in an expansion of the fungicidal activity spectrum or prevents the development of fungicide resistance. Furthermore, synergistic effects are often achieved.

[0411] Furthermore, the present invention relates to agricultural chemical compositions comprising a mixture of at least one compound I (component 1) and at least one additional active compound (e.g., selected from groups A to K) for plant protection) (component 2), particularly an additional fungicide, such as one or more fungicides from groups A to K as described above, and, if desired, a suitable solvent or solid carrier. These mixtures are of particular interest because many of them exhibit higher efficacy against harmful fungi at the same application rate. Moreover, mixtures of compound I and at least one fungicide from groups A to K as described above are more effective against harmful fungi than compounds I alone or individual fungicides from groups A to K).

[0412] By applying compound I together with at least one active compound from groups A) to O), a synergistic effect can be obtained, i.e., a simple sum (synergistic mixture) of effects greater than the individual effects.

[0413] This can be achieved by applying Compound I and at least one other active compound simultaneously (in combination, e.g., as a barrel mix) or separately or sequentially, wherein the time interval between individual applications is chosen to ensure that the initially applied active compound remains present at the site of action in sufficient quantity when one or more other active substances are applied. The order of application is not important for the implementation of the invention.

[0414] When compound I and pest control agent II are applied sequentially, the time between the two applications can vary, for example, from 2 hours to 7 days. A range of 0.25 hours to 30 days, preferably 0.5 hours to 14 days, particularly 1 hour to 7 days or 1.5 hours to 5 days, and even more preferably a wider range of 2 hours to 1 day is also possible.

[0415] In the binary mixtures and compositions according to the invention, the weight ratio of component 1) to component 2) generally depends on the characteristics of the active component used, typically in the range of 1:10000 to 10000:1, often in the range of 1:100 to 100:1, frequently in the range of 1:50 to 50:1, preferably in the range of 1:20 to 20:1, more preferably in the range of 1:5 to 5:1, and particularly in the range of 1:2 to 2:1.

[0416] According to other embodiments of binary mixtures and compositions, the weight ratio of component 1) to component 2) is generally in the range of 1000:1 to 1:1, often in the range of 100:1 to 1:1, frequently in the range of 50:1 to 1:1, preferably in the range of 20:1 to 1:1, more preferably in the range of 5:1 to 1:1, and particularly in the range of 2:1 to 1:1.

[0417] According to other embodiments of the binary mixtures and compositions, the weight ratio of component 1) to component 2) is generally in the range of 1:1 to 1:1000, often in the range of 1:1 to 1:100, frequently in the range of 1:1 to 1:50, preferably in the range of 1:1 to 1:20, more preferably in the range of 1:1 to 1:5, and particularly in the range of 1:1 to 1:2.

[0418] In the ternary mixture, i.e., the composition according to the invention comprising component 1) and component 2) and compound III (component 3), the weight ratio of component 1) to component 2) is in the range of 1:100 to 100:1, often in the range of 1:50 to 50:1, preferably in the range of 1:20 to 20:1, more preferably in the range of 1:5 to 5:1, and particularly in the range of 1:2 to 2:1, and the weight ratio of component 1) to component 3) is in the range of 1:100 to 100:1, often in the range of 1:50 to 50:1, preferably in the range of 1:20 to 20:1, more preferably in the range of 1:5 to 5:1, and particularly in the range of 1:2 to 2:1.

[0419] If necessary, any additional active components may be added to component 1 at a ratio of 20:1 to 1:20.

[0420] These ratios are also suitable for the mixtures of the present invention applied via seed treatment.

[0421] The antifungal effect of the mixture according to the present invention can be demonstrated by the tests described below.

[0422] The percentage of visually determined infected leaf area was converted into efficacy as a percentage of the untreated control.

[0423] The power (E) is calculated using Abbot's formula as follows:

[0424] E = (1 - α / β) · 100

[0425] α corresponds to the fungicidal infection rate of the treated plants, expressed as a percentage, and

[0426] β corresponds to the percentage of fungicide infection in untreated (control) plants.

[0427] Efficacy 0 means that the infection level of the treated plants corresponds to the infection level of the untreated control plants; efficacy 100 means that the treated plants were not infected.

[0428] The expected efficacy of a combination of active compounds can be calculated using the Colby formula (Colby, SR, “Calculating synergistic and antagonistic responses of herbicide combinations”, Weeds). 15(Pages 20-22, 1967) to determine and compare the observed efficacy.

[0429] Colby's formula:

[0430] E = x + y - x · y / 100

[0431] E represents the expected efficacy when using a mixture of active compounds A and B at concentrations a and b, expressed as a percentage of the untreated control.

[0432] x represents the efficacy of active compound A at a concentration of a, expressed as a percentage of the untreated control.

[0433] y represents the efficacy of active compound B at a concentration of b, expressed as a percentage of the untreated control.

[0434] Microtest

[0435] The active compound was prepared separately as a stock solution with a concentration of 10,000 ppm in dimethyl sulfoxide.

[0436] Mix the stock solution according to the specified ratio, transfer it to a microtiter plate (MTP) using a pipette, and dilute it with water to the specified concentration.

[0437] Example 1 - Activity against Botrytis cinerea (gray mold) in microtiter plate test

[0438] Mix the stock solution according to the specified ratio, transfer it to a microtiter plate (MTP) using a pipette, and dilute with water to the specified concentration. Then add a spore suspension of *Botrytis cinerea* in bio-malt or yeast-bacterial peptone-sodium acetate aqueous solution. Place these plates in a water vapor saturated chamber at 18°C. Measure the MTP at 405 nm using an absorbance spectrophotometer 7 days after inoculation.

[0439]

[0440]

[0441] Example 2 - Activity against rice blast fungus in microtiter plate test

[0442] Mix the stock solution according to the specified ratio, transfer it to a microtiter plate (MTP) using a pipette, and dilute with water to the specified concentration. Then add the spore suspension of *Pyrrosia lingua* in bio-malt or yeast-bacterial peptone-glycerol aqueous solution. Place these plates in a water vapor saturated chamber at 18°C. Measure the MTP at 405 nm using an absorbance spectrophotometer 7 days after inoculation.

[0443]

[0444] Example 3 - Activity against wheat leaf spot disease caused by *Syngonium oryzae*

[0445] Mix the stock solution according to the specified ratio, transfer it to a microtiter plate (MTP) using a pipette, and dilute with water to the specified concentration. Then add a spore suspension of *Syngonium spp.* in bio-malt or yeast-bacterial peptone-glycerol aqueous solution. Place these plates in a water vapor saturated chamber at 18°C. Measure the MTP at 405 nm using an absorbance spectrophotometer 7 days after inoculation.

[0446]

[0447] Example 4 - Activity against Corynebacterium sarmentosum

[0448] Mix the stock solution according to the specified ratio, transfer it to a microtiter plate (MTP) using a pipette, and dilute with water to the specified concentration. Then add a spore suspension of *Corynebacterium sarmentosum* in bio-malt or yeast-bacterial peptone-glycerol aqueous solution. Place these plates in a water vapor saturated chamber at 18°C. Measure the MTP at 405 nm using an absorbance spectrophotometer 7 days after inoculation.

[0449]

[0450] The measured parameters were compared with the growth rate (100%) of the control variant of the inactive compound and the blank value of the fungal-free and inactive compound to determine the relative growth rate (in %) of pathogens in the corresponding active compound.

[0451] The expected efficacy of mixtures of active compounds was determined using the Colby formula [RS Colby, “Calculating synergistic and antagonistic responses of herbicide combinations”, Weeds, 15, 20-22 (1967)] and compared with observed efficacy.

Claims

1. A fungicidal mixture comprising, as an active ingredient, the following: 1) At least one active compound having formula I, or its N-oxide, or an agriculturally useful salt. in R 1 It is H or CH3; R 2 Selected from CN, CH3, CH(CH3)2, CH2CH=CH2, CH2CCH; X 1 Selected from H, Cl, F, CH3; X 2 Selected from H, F, and OCH3; Y is Cl, F, or CH3; And the following items as component 1): 2) At least one active compound II selected from the group consisting of: - Respiratory inhibitors: azoxystrobin, pyraclostrobin, tetrazoxystrobin, pyridabenamide, pyridabenamide (A.2.6Ic); boscalid, fluopyram, isopyram, fluopyram hydroxylamine, indapoxetine, fluopyram, triflupyridamole, fluazinam; - Sterol biosynthesis inhibitors (SBI fungicides): difenoconazole, prothioconazole, chlorfenapyr, methyl 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propionate, methyl 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propionate; - Nucleic acid synthesis inhibitor: Isopropylquinoline; -An amino acid and protein synthesis inhibitor: pyrimethanil; - Signal transduction inhibitor: fludioxonil; - Inhibitors with multi-site action: sulfur, dithiazolinone, Cu, - Cell wall synthesis inhibitor: tricyclazole; - Plant defense inducers: isothiazine, cyclohexane-calcium; phosphite and its salts; -Mechanism of action unknown: dichlorvos, flusulfanilamide, isobutylethoxyquin, fluoxazine; - Insecticidal compounds with unknown or uncertain modes of action: fluopyram; The weight ratio of these components is 1:15 to 15:

1.

2. The mixture according to claim 1, wherein, This group 1) is selected from the following groups: I-1: 4-(8-fluoroquinolin-3-yl)-2,2-dimethylquinazolin-1(2H-formonitrile) I-2: 8-Chloro-1,2,2-trimethyl-4-(quinolin-3-yl)-1,2-dihydroquinazolin I-3: 8-Fluoro-4-(8-Fluoro-4-methylquinolin-3-yl)-1,2,2-trimethyl-1,2-dihydroquinazolin I-4: 8-Chloro-1,2,2-trimethyl-4-(8-methylquinolin-3-yl)-1,2-dihydroquinazolin I-5: 8-Fluoro-1,2,2-trimethyl-4-(8-methylquinolin-3-yl)-1,2-dihydroquinazolin I-6: I-2: 8-Chloro-1,2,2-trimethyl-4-(8-methylquinolin-3-yl)-1,2-dihydroquinazolin I-7: 2,2-Dimethyl-4-(quinolin-3-yl)quinazolin-1(2H)-formonitrile I-8: 4-(8-chloroquinoline-3-yl)-2,2-dimethylquinazolin-1(2H-formonitrile) I-9: 8-Fluoro-4-(8-fluoroquinolin-3-yl)-2,2-dimethylquinazolin-1(2H)-formonitrile I-10: 8-Fluoro-4-(8-Fluoro-4-methylquinolin-3-yl)-2,2-dimethylquinazolin-1(2H-formonitrile I-11: 8-Fluoro-2,2-dimethyl-4-(8-methylquinolin-3-yl)quinazolin-1(2H)-formonitrile I-12: 8-Chloro-2,2-dimethyl-4-(8-methylquinolin-3-yl)quinazolin-1(2H)-formonitrile I-13: 8-Fluoro-2,2-dimethyl-4-(quinolin-3-yl)quinazolin-1(2H)-formonitrile I-14: 8-Chloro-4-(8-chloroquinoline-3-yl)-2,2-dimethylquinazolin-1(2H)-formonitrile I-15: 7,8-Difluoro-1,2,2-trimethyl-4-(quinolin-3-yl)-1,2-dihydroquinazolin I-16: 4-(8-chloroquinoline-3-yl)-8-fluoro-2,2-dimethylquinazolin-1(2H)-formonitrile I-17: 8-Fluoro-4-(8-fluoroquinolin-3-yl)-1-isopropyl-2,2-dimethyl-1,2-dihydroquinazolin I-18: 2,2-Dimethyl-4-(8-methylquinolin-3-yl)quinazolin-1(2H)-formonitrile I-19: 1-Allyl-7,8-difluoro-4-(8-fluoro-4-methylquinolin-3-yl)-2,2-dimethyl-1,2-dihydroquinazolin I-20: 4-(8-fluoro-4-methylquinoline-3-yl)-2,2-dimethylquinazolin-1(2H-formonitrile) I-21: 7,8-Difluoro-4-(8-fluoro-4-methylquinolin-3-yl)-1,2,2-trimethyl-1,2-dihydroquinazolin I-22: 8-Fluoro-4-(8-fluoroquinolin-3-yl)-1,2,2-trimethyl-1,2-dihydroquinazolin I-23: 7,8-Difluoro-4-(8-fluoro-4-methylquinolin-3-yl)-2,2-dimethyl-1-(prop-2-yn-1-yl)-1,2-dihydroquinazolin I-24: 4-(8-fluoro-4-methylquinoline-3-yl)-7-methoxy-1,2,2,8-tetramethyl-1,2-dihydroquinazolinoline I-25: 4-(8-fluoroquinoline-3-yl)-7-methoxy-1,2,2,8-tetramethyl-1,2-dihydroquinazoline.

3. The mixture according to any one of claims 1 or 2, comprising compound I and compound II in a weight ratio of 1:4 to 4:

1.

4. The mixture according to any one of claims 1 to 3, wherein, Component 2) is at least one active compound II selected from the group consisting of: -Respiratory inhibitors I: azoxystrobin, pyraclostrobin, tetrazoxystrobin, boscalid, fluopyram, isothiazamide, fluopyram, indapoxetine, fluopyram, fluopyram; - Sterol biosynthesis inhibitors (SBI fungicides): difenoconazole, prothioconazole, chlorfenapyr; -An amino acid and protein synthesis inhibitor: pyrimethanil; - Signal transduction inhibitor: fludioxonil; - Inhibitors with multi-site action: sulfur, dithiazolinone, Cu; - Cell wall synthesis inhibitor: tricyclazole; - Plant defense inducers: Cyclocycline-calcium; Phosphates -Mechanism of action unknown: dichlorothiazide, isobutylethoxyquinoline, fluoxetine.

5. The mixture according to any one of claims 1 to 4, wherein, Component 2) is at least one active compound II selected from the group consisting of: -Respiratory inhibitors I: Pyraclostrobin, Tetracycline, Cyazofamid, Fluopyram; - Sterol biosynthesis inhibitor (SBI fungicide): Chlorfluazuron; -An amino acid and protein synthesis inhibitor: pyrimethanil; - Inhibitors with multi-site action: sulfur, dithiazolinone, Cu; -Mechanism of action unknown: fluoxetine.

6. An agricultural chemical composition comprising a solvent or solid carrier and the composition according to any one of claims 1 to 5.

7. Use of the mixture as defined in any one of claims 1 to 6 or the agricultural chemical composition as defined in claim 6 for the control of pathogenic fungi of plants.

8. The use according to claim 7, for resistance to gray mold and white mold diseases.

9. The use according to claim 7, for resistance to rice leaf, neck, nape and panicle blast diseases.

10. The use according to claim 7, for resistance to diseases of pear and stone fruit.

11. The use according to claim 7, for resistance to leaf spot disease in soybeans or vegetables.

12. The use according to claim 7, for resistance to Rhizoctonia solani disease (Rhizoctonia solani) in several crops such as grass, cereals, potatoes and leafy vegetables.

13. The use according to claim 7, for resisting storage-complex infectious diseases in pears and stone fruits.

14. The use according to claim 7, for resisting various soil and seed-borne pathogens.

15. A method for controlling plant pathogenic harmful fungi, the method comprising treating the fungi, their habitat, or seeds, soil, or plants to be protected from fungal infection with an effective amount of compound I and compound II as defined in any one of claims 1 to 5, and compound III, or a composition as defined in claim 6.

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