Preparation method of water-soluble anti-allergy and anti-aging composition

Abstract

The invention relates to the technical field of anti-aging compositions, and discloses a preparation method of a water-soluble anti-allergy anti-aging composition, which comprises the following steps: mixing peony flower water, peony branches, a peony root bark extract, a peony root extract, butanediol, 1 part by weight of glycerol, polysorbate-20, ergothioneine, inositol, a mussel extract, 1, 2-propylene glycol and water to obtain a mixture; and adding 1, 2-hexanediol, modified sinapic acid, the essence extract and the intermediate 1 into a stirrer, and stirring to obtain the water-soluble anti-allergy and anti-aging composition. The amino acid contained in the intermediate 1 in the water-soluble anti-allergy and anti-aging composition can effectively improve the skin, and has an excellent whitening effect and a good moisturizing effect; wherein the peony flower water, the peony branches, the peony root bark extract, the peony root extract, the butanediol, the glycerol, the polysorbate-20, the ergothioneine, the inositol and the mussel extract have the effects of repairing, nourishing, relieving, resisting wrinkles and tightening.

Description

Technical Field

[0001] This invention relates to the field of anti-aging composition technology, specifically to a method for preparing a water-soluble soothing and anti-aging composition. Background Technology

[0002] Skin aging is an inevitable stage of human life, influenced by environmental factors and the complex morphological structure of the body. In recent years, due to irregular diet and lifestyle, many people's skin has begun to experience accelerated aging at different levels, resulting in wrinkles, sagging, and other problems. For example, CN106726923A discloses a cosmetic additive and its preparation method. This cosmetic additive is composed of mulberry bark extract, pomegranate flower extract, chamomile extract, and cherry blossom leaf extract, which has good whitening effects, but its antibacterial and soothing effects have not been improved. Summary of the Invention

[0003] (a) Technical problems to be solved

[0004] To address the shortcomings of existing technologies, this invention provides a method for preparing a water-soluble soothing and anti-aging composition, which has repairing, nourishing, soothing, anti-wrinkle, firming, antibacterial, and moisturizing effects, and is suitable for sensitive skin, gentle and non-irritating.

[0005] (II) Technical Solution

[0006] To achieve the above objectives, the present invention provides the following technical solution: a method for preparing a water-soluble soothing and anti-aging composition, wherein the method for preparing the water-soluble soothing and anti-aging composition is as follows:

[0007] (1) N-glycine, L-proline, L-threonine and L-serine were mixed and added to a flask. N,N-dimethylformamide was added and heated and stirred until dissolved under reflux. Sodium carbonate and zinc acetate were added, followed by dimethyl carbonate. Nitrogen gas was purged to remove air, and heating was continued for 6-10 hours. The mixture was filtered while hot, frozen and dried to obtain intermediate 1.

[0008] (2) Chitosan and ε-caprolactone were added to the reactor and stirred evenly. Then, stannous octoate catalyst was added and nitrogen gas was introduced for protection. The reaction was carried out at 100-130℃ for 6-13 hours. After the reaction was completed, the mixture was washed and dried to obtain chitosan-modified ε-caprolactone.

[0009] (3) Add sinapic acid to the methanol solution, stir to dissolve, and then continue to add chitosan-modified ε-caprolactone and p-toluenesulfonic acid catalyst. React at 90-110℃ for 6-10h. After the reaction is completed, distill under reduced pressure, wash and dry to obtain modified sinapic acid.

[0010] (4) Add 20-30 parts by weight of gardenia, 15-25 parts by weight of elderberry and 10-30 parts by weight of isatis root into an ethanol solution, heat and reflux, and remove the ethanol by vacuum distillation after extraction to obtain gardenia extract, elderberry extract and isatis root extract, i.e. essence extract.

[0011] (5) Add 65-75 parts by weight of peony flower water, 0.5-1.5 parts by weight of peony branches, 1-10 parts by weight of peony root bark extract, 1-5 parts by weight of peony root extract, 10-15 parts by weight of butylene glycol, 1-5 parts by weight of glycerin, 1-5 parts by weight of polysorbate-20, 0.5-1.5 parts by weight of ergothioneine, 0.5-1.5 parts by weight of inositol, 0.05-0.3 parts by weight of mussel extract, 1-3 parts by weight of 1,2-hexanediol, 0.2-0.5 parts by weight of modified sinapic acid, 1-2 parts by weight of essence extract, and 0.6-0.8 parts by weight of intermediate 1 to a stirrer and stir for 10-15 minutes. After stirring, a water-soluble soothing and anti-aging composition is obtained.

[0012] Preferably, the mass ratio of N-glycine, L-proline, L-threonine, L-serine, sodium carbonate, zinc acetate, and dimethyl carbonate in (1) is 1:1.2-1.4:0.8-1:1.3-1.6.

[0013] Preferably, the mass ratio of chitosan, ε-caprolactone, and stannous octoate catalyst in (2) is 1.1-1.4:1:0.01-0.03.

[0014] Preferably, the mass ratio of sinapic acid, chitosan-modified ε-caprolactone, and p-toluenesulfonic acid catalyst in (3) is 0.8-1.2:1:1.4-1.6.

[0015] Preferably, the reaction time in (4) is 15-25h.

[0016] (iii) Beneficial technical effects

[0017] This invention involves adding peony flower water, peony branches, peony root bark extract, peony root extract, butylene glycol, 1 part by weight of glycerin, polysorbate-20, ergothioneine, inositol, mussel extract, 1,2-hexanediol, modified sinapic acid, essence extract, and intermediate 1 into a stirrer, stirring, and then obtaining a water-soluble soothing and anti-aging composition.

[0018] The intermediate 1 in the water-soluble soothing and anti-aging composition contains amino acids that effectively improve the skin, exhibiting excellent whitening and moisturizing effects. The chitosan and sinapic acid groups in the modified sinapic acid provide antioxidant benefits. The essence extracts provide nutritional and functional supplementation, adhering more tightly to the skin surface for better hydration, moisturizing, and antibacterial effects. The peony flower water, peony branches, peony root bark extract, peony root extract, butylene glycol, glycerin, polysorbate-20, ergothioneine, inositol, and mussel extract possess repairing, nourishing, soothing, anti-wrinkle, and firming effects. Detailed Implementation

[0019] Preparation method of peony flower water: According to the reference "Dual inhibitory effect of peony flower water extract on renin and ACE", take 1g of each of the dried peony petals and two peony petal samples after grinding into powder, dissolve in 10mL of water, shake for 1min, sonicate for 5min, extract by shaking on a shaker at 28℃ for 90min, centrifuge, take the supernatant and filter through a 0.45μm filter membrane to obtain the sample water extract, labeled as 100mg / mL, and store at 4℃ for later use.

[0020] Peony root bark extract: Peony root bark extract (100g / bottle, batch number BLK-260AZRO-5), Innovacos Corporation.

[0021] Preparation method of peony root extract: Referring to the reference "Analgesic effect of peony root extract on neuropathic pain", fresh peony was harvested from Ganzhou. An appropriate amount of peony root was boiled in twice the amount of distilled water for 1 hour, then filtered. The residue was extracted again with distilled water upon heating. The two filtrates were combined, concentrated using a rotary evaporator, and then placed in three times the amount of 95% ethanol for 48 hours. The mixture was then filtered through a rotary evaporator and a vacuum filter, and the ethanol in the filtrate was recovered until no alcohol odor remained. This solution was prepared for analgesic testing and adjusted to a concentration of 4 g / ml for future use in the pharmaceutical industry.

[0022] Example 1

[0023] (1) N-glycine, L-proline, L-threonine and L-serine were mixed and added to a flask. N,N-dimethylformamide was added and heated and stirred under reflux until dissolved. Sodium carbonate and zinc acetate were added, followed by dimethyl carbonate. The mass ratio of N-glycine, L-proline, L-threonine, L-serine, sodium carbonate, zinc acetate and dimethyl carbonate was 1:1.2:0.8:1.3. Nitrogen gas was purged to remove air and the mixture was heated for 6 hours. The mixture was filtered while hot, frozen and dried to obtain intermediate 1.

[0024] (2) Chitosan and ε-caprolactone were added to the reactor and stirred evenly. Then, stannous octoate catalyst was added, wherein the mass ratio of chitosan, ε-caprolactone and stannous octoate catalyst was 1.1:1:0.01. Nitrogen gas was introduced for protection, and the reaction was carried out at 100°C for 6 hours. After the reaction was completed, the mixture was washed and dried to obtain chitosan-modified ε-caprolactone.

[0025] (3) Add sinapic acid to the methanol solution, stir to dissolve, and then continue to add chitosan-modified ε-caprolactone and p-toluenesulfonic acid catalyst, wherein the mass ratio of sinapic acid, chitosan-modified ε-caprolactone and p-toluenesulfonic acid catalyst is 0.8:1:1.4. React at 90℃ for 6h, and after the reaction is completed, distill under reduced pressure, wash and dry to obtain modified sinapic acid;

[0026] (4) Add 20 parts by weight of gardenia, 15 parts by weight of elderberry and 10 parts by weight of isatis root into an ethanol solution, heat and reflux for 15 hours, remove ethanol by vacuum distillation after extraction, and obtain gardenia extract, elderberry extract and isatis root extract, i.e. essence extract.

[0027] (5) Add 65 parts by weight of peony flower water, 0.5 parts by weight of peony branches, 1 part by weight of peony root bark extract, 1 part by weight of peony root extract, 10 parts by weight of butylene glycol, 1 part by weight of glycerin, 1 part by weight of polysorbate-20, 0.5 parts by weight of ergothioneine, 0.5 parts by weight of inositol, 0.05 parts by weight of mussel extract, 1 part by weight of 1,2-hexanediol, 0.2 parts by weight of modified sinapic acid, 1 part by weight of essence extract, and 0.6 parts by weight of intermediate 1 to a stirrer and stir for 10 minutes. After stirring, a water-soluble soothing and anti-aging composition is obtained.

[0028] Example 2

[0029] (1) N-glycine, L-proline, L-threonine and L-serine were mixed and added to a flask. N,N-dimethylformamide was added and heated and stirred under reflux until dissolved. Sodium carbonate and zinc acetate were added, followed by dimethyl carbonate. The mass ratio of N-glycine, L-proline, L-threonine, L-serine, sodium carbonate, zinc acetate and dimethyl carbonate was 1:1.4:1:1.6. Nitrogen gas was purged to remove air and the mixture was heated for 10 hours. The mixture was filtered while hot, frozen and dried to obtain intermediate 1.

[0030] (2) Chitosan and ε-caprolactone were added to the reactor and stirred evenly. Then, stannous octoate catalyst was added, wherein the mass ratio of chitosan, ε-caprolactone and stannous octoate catalyst was 1.4:1:0.03. Nitrogen gas was introduced for protection, and the reaction was carried out at 130°C for 13 hours. After the reaction was completed, the mixture was washed and dried to obtain chitosan-modified ε-caprolactone.

[0031] (3) Add sinapic acid to the methanol solution, stir to dissolve, and then continue to add chitosan-modified ε-caprolactone and p-toluenesulfonic acid catalyst, wherein the mass ratio of sinapic acid, chitosan-modified ε-caprolactone and p-toluenesulfonic acid catalyst is 1.2:1:1.6. React at 110℃ for 10h, and after the reaction is completed, distill under reduced pressure, wash and dry to obtain modified sinapic acid;

[0032] (4) Add 30 parts by weight of gardenia, 25 parts by weight of elderberry and 30 parts by weight of isatis root into an ethanol solution, heat and reflux for 25 hours, remove ethanol by vacuum distillation after extraction, and obtain gardenia extract, elderberry extract and isatis root extract, i.e. essence extract.

[0033] (5) Add 75 parts by weight of peony flower water, 1.5 parts by weight of peony branches, 10 parts by weight of peony root bark extract, 5 parts by weight of peony root extract, 15 parts by weight of butylene glycol, 5 parts by weight of glycerin, 5 parts by weight of polysorbate-20, 1.5 parts by weight of ergothioneine, 1.5 parts by weight of inositol, 0.3 parts by weight of mussel extract, 3 parts by weight of 1,2-hexanediol, 0.5 parts by weight of modified sinapic acid, 2 parts by weight of essence extract, and 0.8 parts by weight of intermediate 1 to a stirrer and stir for 15 minutes. After stirring, a water-soluble soothing and anti-aging composition is obtained.

[0034] Example 3

[0035] (1) N-glycine, L-proline, L-threonine and L-serine are mixed and added to a flask. N,N-dimethylformamide is added and heated and stirred under reflux until dissolved. Sodium carbonate and zinc acetate are added, followed by dimethyl carbonate. The mass ratio of N-glycine, L-proline, L-threonine, L-serine, sodium carbonate, zinc acetate and dimethyl carbonate is 1:1.2-1.4:0.8-1:1.3-1.6. Nitrogen gas is passed through to remove air and the mixture is heated for 6-10 hours. The mixture is filtered while hot, frozen and dried to obtain intermediate 1.

[0036] (2) Chitosan and ε-caprolactone were added to the reactor and stirred evenly. Then, stannous octoate catalyst was added. The mass ratio of chitosan, ε-caprolactone and stannous octoate catalyst was 1.1-1.4:1:0.01-0.03. Nitrogen gas was introduced for protection. The reaction was carried out at 100-130℃ for 6-13 hours. After the reaction was completed, the mixture was washed and dried to obtain chitosan-modified ε-caprolactone.

[0037] (3) Add sinapic acid to the methanol solution, stir to dissolve, and then continue to add chitosan-modified ε-caprolactone and p-toluenesulfonic acid catalyst, wherein the mass ratio of sinapic acid, chitosan-modified ε-caprolactone and p-toluenesulfonic acid catalyst is 0.8-1.2:1:1.4-1.6. React at 90-110℃ for 6-10h, and after the reaction is completed, distill under reduced pressure, wash and dry to obtain modified sinapic acid;

[0038] (4) Add 20-30 parts by weight of gardenia, 15-25 parts by weight of elderberry and 10-30 parts by weight of isatis root into an ethanol solution, heat under reflux for 15-25 hours, remove ethanol by vacuum distillation after extraction, and obtain gardenia extract, elderberry extract and isatis root extract, i.e. essence extract.

[0039] (5) Add 65-75 parts by weight of peony flower water, 0.5-1.5 parts by weight of peony branches, 1-10 parts by weight of peony root bark extract, 1-5 parts by weight of peony root extract, 10-15 parts by weight of butylene glycol, 1-5 parts by weight of glycerin, 1-5 parts by weight of polysorbate-20, 0.5-1.5 parts by weight of ergothioneine, 0.5-1.5 parts by weight of inositol, 0.05-0.3 parts by weight of mussel extract, 1-3 parts by weight of 1,2-hexanediol, 0.2-0.5 parts by weight of modified sinapic acid, 1-2 parts by weight of essence extract, and 0.6-0.8 parts by weight of intermediate 1 to a stirrer and stir for 10-15 minutes. After stirring, a water-soluble soothing and anti-aging composition is obtained.

[0040] Example 4

[0041] (1) N-glycine, L-proline, L-threonine and L-serine were mixed and added to a flask. N,N-dimethylformamide was added and heated and stirred under reflux until dissolved. Sodium carbonate and zinc acetate were added, followed by dimethyl carbonate. The mass ratio of N-glycine, L-proline, L-threonine, L-serine, sodium carbonate, zinc acetate and dimethyl carbonate was 1:1.2:0.8:1.3. Nitrogen gas was purged to remove air and the mixture was heated for 6 hours. The mixture was filtered while hot, frozen and dried to obtain intermediate 1.

[0042] (2) Chitosan and ε-caprolactone were added to the reactor and stirred evenly. Then, stannous octoate catalyst was added, wherein the mass ratio of chitosan, ε-caprolactone and stannous octoate catalyst was 1.1:1:0.01. Nitrogen gas was introduced for protection, and the reaction was carried out at 100°C for 6 hours. After the reaction was completed, the mixture was washed and dried to obtain chitosan-modified ε-caprolactone.

[0043] (3) Add sinapic acid to the methanol solution, stir to dissolve, and then continue to add chitosan-modified ε-caprolactone and p-toluenesulfonic acid catalyst, wherein the mass ratio of sinapic acid, chitosan-modified ε-caprolactone and p-toluenesulfonic acid catalyst is 1.2:1:1.6. React at 110℃ for 10h, and after the reaction is completed, distill under reduced pressure, wash and dry to obtain modified sinapic acid;

[0044] (4) Add 30 parts by weight of gardenia, 25 parts by weight of elderberry and 30 parts by weight of isatis root into an ethanol solution, heat and reflux for 25 hours, remove ethanol by vacuum distillation after extraction, and obtain gardenia extract, elderberry extract and isatis root extract, i.e. essence extract.

[0045] (5) Add 65-75 parts by weight of peony flower water, 0.5-1.5 parts by weight of peony branches, 1-10 parts by weight of peony root bark extract, 1-5 parts by weight of peony root extract, 10-15 parts by weight of butylene glycol, 1-5 parts by weight of glycerin, 1-5 parts by weight of polysorbate-20, 0.5-1.5 parts by weight of ergothioneine, 0.5-1.5 parts by weight of inositol, 0.05-0.3 parts by weight of mussel extract, 1-3 parts by weight of 1,2-hexanediol, 0.2-0.5 parts by weight of modified sinapic acid, 1-2 parts by weight of essence extract, and 0.6-0.8 parts by weight of intermediate 1 to a stirrer and stir for 10-15 minutes. After stirring, a water-soluble soothing and anti-aging composition is obtained.

[0046] Example 5

[0047] (1) N-glycine, L-proline, L-threonine and L-serine were mixed and added to a flask. N,N-dimethylformamide was added and heated and stirred under reflux until dissolved. Sodium carbonate and zinc acetate were added, followed by dimethyl carbonate. The mass ratio of N-glycine, L-proline, L-threonine, L-serine, sodium carbonate, zinc acetate and dimethyl carbonate was 1:1.4:1:1.6. Nitrogen gas was purged to remove air and the mixture was heated for 10 hours. The mixture was filtered while hot, frozen and dried to obtain intermediate 1.

[0048] (2) Chitosan and ε-caprolactone were added to the reactor and stirred evenly. Then, stannous octoate catalyst was added, wherein the mass ratio of chitosan, ε-caprolactone and stannous octoate catalyst was 1.4:1:0.03. Nitrogen gas was introduced for protection, and the reaction was carried out at 130°C for 13 hours. After the reaction was completed, the mixture was washed and dried to obtain chitosan-modified ε-caprolactone.

[0049] (3) Add sinapic acid to the methanol solution, stir to dissolve, and then continue to add chitosan-modified ε-caprolactone and p-toluenesulfonic acid catalyst, wherein the mass ratio of sinapic acid, chitosan-modified ε-caprolactone and p-toluenesulfonic acid catalyst is 0.8-1.2:1:1.4-1.6. React at 90-110℃ for 6-10h, and after the reaction is completed, distill under reduced pressure, wash and dry to obtain modified sinapic acid;

[0050] (4) Add 20-30 parts by weight of gardenia, 15-25 parts by weight of elderberry and 10-30 parts by weight of isatis root into an ethanol solution, heat under reflux for 15-25 hours, remove ethanol by vacuum distillation after extraction, and obtain gardenia extract, elderberry extract and isatis root extract, i.e. essence extract.

[0051] (5) Add 65 parts by weight of peony flower water, 0.5 parts by weight of peony branches, 1 part by weight of peony root bark extract, 1 part by weight of peony root extract, 10 parts by weight of butylene glycol, 1 part by weight of glycerin, 1 part by weight of polysorbate-20, 0.5 parts by weight of ergothioneine, 0.5 parts by weight of inositol, 0.05 parts by weight of mussel extract, 1 part by weight of 1,2-hexanediol, 0.2 parts by weight of modified sinapic acid, 1 part by weight of essence extract, and 0.6 parts by weight of intermediate 1 to a stirrer and stir for 10 minutes. After stirring, a water-soluble soothing and anti-aging composition is obtained.

[0052] Comparative Example 1

[0053] Add 65 parts by weight of peony flower water, 0.5 parts by weight of peony branches, 1 part by weight of peony root bark extract, 1 part by weight of peony root extract, 10 parts by weight of butylene glycol, 1 part by weight of glycerin, 1 part by weight of polysorbate-20, 0.5 parts by weight of ergothioneine, 0.5 parts by weight of inositol, 0.05 parts by weight of mussel extract, 1 part by weight of 1,2-hexanediol, 0.2 parts by weight of modified sinapic acid, and 1 part by weight of the essence extract to a stirrer and stir for 10 minutes to obtain a water-soluble soothing and anti-aging composition.

[0054] Comparative Example 2

[0055] 65 parts by weight of peony flower water, 0.5 parts by weight of peony branches, 1 part by weight of peony root bark extract, 1 part by weight of peony root extract, 10 parts by weight of butylene glycol, 1 part by weight of glycerin, 1 part by weight of polysorbate-20, 0.5 parts by weight of ergothioneine, 0.5 parts by weight of inositol, 0.05 parts by weight of mussel extract, 1 part by weight of 1,2-hexanediol, and 0.2 parts by weight of modified sinapic acid were added to a stirrer and stirred for 10 minutes to obtain a water-soluble soothing and anti-aging composition.

[0056] Antibacterial test method: Place 5 circular filter papers with a diameter of 6 mm into the gels of the examples and comparative examples, sterilize them by high-pressure steam (120 °C, 0.12 MPa) for 10 min, take 100 μL of each bacterial suspension and evenly spread it on the surface of the culture medium petri dish, use sterile forceps to stick each filter paper on the bacteria-containing petri dish, culture at 37 °C for 24 h, measure the diameter of the antibacterial circle of the circular filter paper, and a qualified antibacterial circle diameter is greater than 10 mm; Select 120 volunteers and divide them into 6 groups, with 20 people in each group. Use the gels prepared in the examples and comparative examples for each group to test the water replenishing effect. The test criteria are "satisfactory" (good skin moisturization) and "general" (skin dryness). The test results are shown in Table 1.

[0057] Table 1: Antibacterial and water replenishing tests.

[0058] project Diameter of the inhibition zone (mm) Hydrating effect Example 1 10.4 satisfy Example 2 11.3 satisfy Example 3 9.7 satisfy Example 4 10.6 satisfy Example 5 10.3 satisfy Comparative Example 1 9.3 generally Comparative Example 2 9.1 generally

[0059] As can be seen from Table 1, the water-soluble anti-allergic and anti-aging composition of the present invention has good water replenishing and antibacterial effects.

[0060] Moisturizing effect test method: Draw a square experimental area of 2×2 cm2 on the left and right forearms of the test subjects. Use the left arm as the test area and the corresponding symmetrical area on the right arm as the blank control. Then use a Corneometer CM825 to test and detect the moisture content of each test site, repeat 5 times respectively, and obtain the average value. Hydration rate = (test value - blank value) / blank value × 100%.

[0061] project Moisturizing effect (%) Example 1 71 Example 2 72 Example 3 71 Example 4 68 Example 5 63 Comparative Example 1 50 Comparative Example 2 49

[0062] As can be seen from Table 2, the water-soluble anti-allergic and anti-aging composition of the present invention has good moisturizing effects.

[0063] In this project, the irritation is evaluated through a red blood cell hemolysis experiment. The red blood cell hemolysis experiment is one of the alternative methods for the rabbit eye irritation test (Draize test). The basic principle is to evaluate the damage of chemicals to eye tissue cells by measuring the hemoglobin elution amount and denaturation degree. Internationally, the RBC experiment is mainly used to evaluate the eye irritation of chemicals such as cosmetics and raw materials. The grading standard is as follows: >100 is non-irritating, 10 < L / D < 100 is slightly irritating. The test is shown in Table 3.

[0064] project Stimulus test Example 1 Non-irritating Example 2 Non-irritating Example 3 Non-irritating Example 4 Non-irritating Example 5 Non-irritating Comparative Example 1 Microstimulation Comparative Example 2 Microstimulation

[0065] As can be seen from Table 3, the water-soluble anti-allergic and anti-aging composition of the present invention is non-irritating.

[0066] The preferred embodiments of the present invention disclosed above are merely illustrative of the invention. These preferred embodiments do not exhaustively describe all details, nor do they limit the invention to the specific implementations described. Clearly, many modifications and variations can be made based on the content of this specification. This specification selects and specifically describes these embodiments to better explain the principles and practical applications of the invention, thereby enabling those skilled in the art to better understand and utilize the invention. The invention is limited only by the claims and their full scope and equivalents.

Claims

1. A method for preparing a water-soluble soothing and anti-aging composition, characterized in that, The preparation method of the water-soluble soothing and anti-aging composition is as follows: (1) N-glycine, L-proline, L-threonine and L-serine were mixed and added to a flask. N,N-dimethylformamide was added and heated and stirred until dissolved under reflux. Sodium carbonate and zinc acetate were added, followed by dimethyl carbonate. Nitrogen gas was purged to remove air, and heating was continued for 6-10 hours. The mixture was filtered while hot, frozen and dried to obtain intermediate 1. (2) Chitosan and ε-caprolactone were added to the reactor and stirred evenly. Then, stannous octoate catalyst was added and nitrogen gas was introduced for protection. The reaction was carried out at 100-130℃ for 6-13 hours. After the reaction was completed, the mixture was washed and dried to obtain chitosan-modified ε-caprolactone. (3) Add sinapic acid to the methanol solution, stir to dissolve, and then continue to add chitosan-modified ε-caprolactone and p-toluenesulfonic acid catalyst. React at 90-110℃ for 6-10h. After the reaction is completed, distill under reduced pressure, wash and dry to obtain modified sinapic acid. (4) Add 20-30 parts by weight of gardenia, 15-25 parts by weight of elderberry and 10-30 parts by weight of isatis root into an ethanol solution, heat and reflux, and remove the ethanol by vacuum distillation after extraction to obtain gardenia extract, elderberry extract and isatis root extract, i.e. essence extract. (5) Add 65-75 parts by weight of peony flower water, 0.5-1.5 parts by weight of peony branches, 1-10 parts by weight of peony root bark extract, 1-5 parts by weight of peony root extract, 10-15 parts by weight of butylene glycol, 1-5 parts by weight of glycerin, 1-5 parts by weight of polysorbate-20, 0.5-1.5 parts by weight of ergothioneine, 0.5-1.5 parts by weight of inositol, 0.05-0.3 parts by weight of mussel extract, 1-3 parts by weight of 1,2-hexanediol, 0.2-0.5 parts by weight of modified sinapic acid, 1-2 parts by weight of essence extract, and 0.6-0.8 parts by weight of intermediate 1 to a stirrer and stir for 10-15 minutes. After stirring, a water-soluble soothing and anti-aging composition is obtained.

2. The method for preparing the water-soluble soothing and anti-aging composition according to claim 1, characterized in that, The mass ratio of N-glycine, L-proline, L-threonine, L-serine, sodium carbonate, zinc acetate, and dimethyl carbonate in (1) is 1:1.2-1.4:0.8-1:1.3-1.

6.

3. The method for preparing the water-soluble soothing and anti-aging composition according to claim 1, characterized in that, The mass ratio of chitosan, ε-caprolactone, and stannous octoate catalyst in (2) is 1.1-1.4:1:0.01-0.

03.

4. The method for preparing the water-soluble soothing and anti-aging composition according to claim 1, characterized in that, The mass ratio of sinapic acid, chitosan-modified ε-caprolactone, and p-toluenesulfonic acid catalyst in (3) is 0.8-1.2:1:1.4-1.

6.

5. The method for preparing the water-soluble soothing and anti-aging composition according to claim 1, characterized in that, The reaction time in (4) is 15-25h.