Traditional Chinese medicine composition for treating eczema and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating eczema and a preparation method, and provides the traditional Chinese medicine composition for treating eczema to solve the problems of various clinical manifestations and high treatment difficulty of eczema clinically at present. The traditional Chinese medicine composition is prepared from 25-35 parts of fried fructus xanthii, 25-35 parts of cortex phellodendri, 25-35 parts of radix sanguisorbae, 5-15 parts of dried alum, 25-35 parts of garden balsam stem, 25-35 parts of fried semen vaccariae, 25-35 parts of folium artemisiae argyi, 25-35 parts of fructus kochiae, 25-35 parts of radix angelicae sinensis and 25-35 parts of radix sophorae flavescentis. On the basis of nourishing blood and moistening dryness, the traditional Chinese medicine has the effects of promoting blood circulation to remove blood stasis, clearing heat, removing dampness and relieving itching, provides a new basis and idea for treatment of patients with chronic hand eczema blood deficiency and wind dryness syndromes, and can effectively treat eczema.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and in particular to a traditional Chinese medicine composition for treating eczema and its preparation method. Background Technology

[0002] Hand eczema, also known as hand dermatitis, is a common inflammatory skin disease that occurs on the hands. Its lesions are diverse, including erythema, papules, vesicles, scales, fissures and hyperkeratosis. Clinically, it is often accompanied by obvious itching or pain caused by fissures [1]. The hands are one of the common sites for eczema. According to the course of the disease, it is divided into acute hand eczema and chronic hand eczema. Chronic hand eczema lesions are mostly manifested as thickened skin, lichenification, scales, fissures, hyperkeratosis, etc., and can also present as acute eczema changes during acute attacks. The course of the disease lasts more than 3 months or recurs 2 or more times a year. Due to the diverse clinical manifestations, complex etiology, prolonged course of disease, recurrent attacks, and difficulty in treatment, and the frequent contact between the hands and the external environment, with the increasing complexity of the environment and the increase of sensitizing substances, it seriously affects the quality of life of patients.

[0003] Most medical practitioners believe that the main causes of chronic eczema are related to the invasion of wind, dampness, and heat, which over time leads to blood deficiency and the generation of wind and dryness. Some medical practitioners also believe that it is related to damp-heat and blood stasis. However, research has found that chronic hand eczema is not simply "blood deficiency and wind dryness". Instead, it is caused by external evils such as wind, dampness, and heat invading the skin, which over time generates blood stasis and toxins. The combination of dampness and blood stasis damages the yin and blood, leading to blood deficiency and the generation of wind and dryness. Its pathogenic factors include the evils of "dampness, heat, blood stasis, and toxins". Therefore, a drug is needed to treat eczema that not only addresses "blood deficiency and wind dryness" but also takes into account "dampness, heat, blood stasis, and toxins". It should nourish the blood while activating blood circulation and removing blood stasis, and be supplemented with clearing heat and drying dampness, dispelling wind and relieving itching. Summary of the Invention

[0004] To address the aforementioned problems, this invention aims to provide a traditional Chinese medicine composition and preparation method for treating eczema. It nourishes the blood while emphasizing blood circulation and removing blood stasis, and is supplemented with heat-clearing, dampness-drying, wind-dispelling, and itch-relieving properties, thus effectively treating eczema.

[0005] To achieve the above objectives, the technical solution adopted by the present invention to solve its technical problem is as follows: A traditional Chinese medicine composition for treating eczema includes the following ingredients: stir-fried Xanthium sibiricum, Phellodendron chinense, Sanguisorba officinalis, dried alum, Clematis chinensis, stir-fried Vaccaria segetalis, Artemisia argyi, Kochia scoparia, Angelica sinensis, and Sophora flavescens; The weight proportions of different raw materials are as follows: 25-35 parts of stir-fried Xanthium sibiricum, 25-35 parts of Phellodendron chinense, 25-35 parts of Sanguisorba officinalis, 5-15 parts of dried alum, 25-35 parts of Clematis chinensis, 25-35 parts of stir-fried Vaccaria segetalis, 25-35 parts of Artemisia argyi, 25-35 parts of Kochia scoparia, 25-35 parts of Angelica sinensis, and 25-35 parts of Sophora flavescens.

[0006] Furthermore, the weight proportions of different raw materials are as follows: 30 parts of stir-fried Xanthium sibiricum, 30 parts of Phellodendron chinense, 30 parts of Sanguisorba officinalis, 10 parts of dried alum, 30 parts of Clematis chinensis, 30 parts of stir-fried Vaccaria segetalis, 30 parts of Artemisia argyi, 30 parts of Kochia scoparia, 30 parts of Angelica sinensis, and 30 parts of Sophora flavescens.

[0007] The pharmacological effects of the different raw materials in this invention are as follows: Angelica sinensis: It nourishes and replenishes blood, and is known as the "holy medicine for blood disorders". It treats all kinds of wind and blood disorders, replenishes all kinds of fatigue, breaks up bad blood, and nourishes new blood. When used externally, it can promote tissue regeneration and relieve pain, and treat skin diseases such as tinea and scabies. This herb is the chief herb, which nourishes blood and moisturizes the skin to promote new blood production.

[0008] Sanguisorba officinalis: It cools the blood and promotes blood circulation, detoxifies and astringes sores. The "Prescriptions Worth a Thousand Gold Pieces" states that boiling it into a concentrated juice for external washing is effective in treating eczema in children. Wang Bu Liu Xing: Invigorates blood circulation, regulates menstruation, dispels wind and cold; Mugwort: warms the meridians and promotes blood circulation; when used externally, it is effective in treating itchy skin. The above three herbs are used as assistant herbs, which help the principal herbs nourish the blood while promoting blood circulation and clearing the meridians to remove blood stasis and eliminate spots, thus treating dark-colored rashes caused by blood stasis.

[0009] Sophora flavescens: Clears heat and dries dampness, kills parasites and relieves itching; it can be used to treat eczema, pruritus, scabies and leprosy. Phellodendron bark: Clears heat and dries dampness; when used externally, it has detoxifying and sore-healing effects. Kochia scoparia: Clears heat and promotes diuresis, dispels wind and relieves itching; used to treat urticaria, eczema, and pruritus. Xanthium sibiricum: It has the effects of dispelling wind and relieving itching, clearing the meridians and relieving pain. It is mainly used to treat scabies, leprosy, and skin itching. Clematis chinensis: dispels wind and dampness, disperses blood stasis and reduces swelling, detoxifies and relieves pain. Alum (dried alum) has astringent and hemostatic properties, antibacterial effects, and dispels wind and relieves itching. Alum: It has insecticidal and detoxifying properties and can be used to treat infections caused by various bacteria.

[0010] The above six herbs serve as adjuvant herbs, working together to clear heat and dampness, dispel wind and relieve itching. When used together, they nourish blood and moisten dryness, promote blood circulation and remove blood stasis, clear heat and dampness, dispel wind and relieve itching. This ensures smooth blood flow, making it easier to eliminate dampness and wind, allowing the skin to receive normal nourishment and leading to recovery from the disease.

[0011] Furthermore, the present invention also provides a method for preparing the traditional Chinese medicine composition as described above, comprising the following steps: S1: Mix and decoct the following ingredients: stir-fried Xanthium sibiricum, Phellodendron chinense, Sanguisorba officinalis, dried alum, Clematis chinensis, stir-fried Vaccaria segetalis, Artemisia argyi, Kochia scoparia, Angelica sinensis, and Sophora flavescens. S2: Cool the decocted medicine to 30-45℃ before use.

[0012] Furthermore, the present invention also provides the application of the aforementioned traditional Chinese medicine composition in the preparation of a traditional Chinese medicine preparation for treating eczema.

[0013] The beneficial effects of this invention are: This invention incorporates roasted Xanthium sibiricum, Phellodendron chinense, Sanguisorba officinalis, alum, Clematis chinensis, roasted Vaccaria segetalis, Artemisia argyi, Kochia scoparia, Angelica sinensis, and Sophora flavescens. Angelica sinensis is the principal herb, nourishing blood and moisturizing the skin to promote new tissue growth. Sanguisorba officinalis, Vaccaria segetalis, and Artemisia argyi act as assistant herbs, assisting the principal herb in nourishing blood while simultaneously promoting blood circulation and clearing the meridians to resolve blood stasis and eliminate rashes, treating dark-colored rashes caused by blood stasis. These herbs, along with other components, act as adjuvant herbs, clearing heat and dampness, dispelling wind, and relieving itching. The combined effects of these herbs nourish blood and moisturize dryness, promote blood circulation and remove blood stasis, clear heat and dampness, dispel wind, and relieve itching, ensuring smooth blood flow, facilitating the elimination of dampness and wind, and allowing the skin to receive normal nourishment, leading to healing. This traditional Chinese medicine composition, based on nourishing blood and moisturizing dryness, and supplemented with promoting blood circulation, removing blood stasis, clearing heat and dampness, and relieving itching, provides a new basis and approach for the treatment of patients with chronic hand eczema due to blood deficiency and wind-dryness.

[0014] This invention incorporates Angelica sinensis to nourish and replenish blood, treat all kinds of wind-related ailments, replenish all kinds of fatigue, break up stagnant blood, and nourish new blood. When applied externally, it can promote tissue regeneration, relieve pain, and treat skin tinea and scabies.

[0015] This invention, by adding Sanguisorba officinalis, Vaccaria segetalis, and Artemisia argyi, not only promotes blood circulation and dispels wind and cold, but also relieves skin itching.

[0016] The present invention, by adding Sophora flavescens, Phellodendron chinense, Kochia scoparia, Xanthium sibiricum, Clematis chinensis, and alum, can not only clear heat and remove dampness, but also dispel wind and relieve itching. Attached Figure Description

[0017] Figure 1 This is a comparison image of the patient's hand before and after treatment in typical case 13 proposed in this invention; Figure 2 This is a comparison image of the patient's hand before and after treatment in typical case 19 proposed in this invention; Figure 3 These are before-and-after comparison images of the patient's hands in typical case 20 proposed in this invention; Figure 4 This is a comparison image of the patient's hand before and after treatment in typical case 21 proposed in this invention; Figure 5 This is a comparison image of the patient's hand before and after treatment in typical case 22 proposed in this invention; Figure 6 This is a comparison image of the patient's hand before and after treatment in typical case 23 proposed in this invention; Figure 7 These are before-and-after comparison images of the patient's hands in typical case 24 proposed in this invention; Figure 8 These are before-and-after comparison images of the patient's hands in typical case 25 proposed in this invention; Figure 9 These are before-and-after comparison images of the patient's hands in typical case 26 proposed in this invention; Figure 10 These are before-and-after comparison images of the patient's hands in typical case 27 proposed in this invention; Figure 11 These are before-and-after comparison images of the patient's hands in typical case 28 proposed in this invention; Figure 12 These are before-and-after comparison images of the patient's feet in typical case 29 proposed in this invention; Figure 13 These are before-and-after comparison images of the hands of patients in typical case 30 proposed in this invention. Figure 14 This is a comparison image of the patient's hand before and after treatment in typical case 31 proposed in this invention. Detailed Implementation

[0018] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention. Example 1

[0019] A traditional Chinese medicine composition for treating eczema includes the following ingredients: stir-fried Xanthium sibiricum, Phellodendron chinense, Sanguisorba officinalis, dried alum, Clematis chinensis, stir-fried Vaccaria segetalis, Artemisia argyi, Kochia scoparia, Angelica sinensis, and Sophora flavescens; The weight proportions of different ingredients are as follows: 30 parts stir-fried Xanthium sibiricum, 30 parts Phellodendron chinense, 30 parts Sanguisorba officinalis, 10 parts dried alum, 30 parts Clematis chinensis, 30 parts stir-fried Vaccaria segetalis, 30 parts Artemisia argyi, 30 parts Kochia scoparia, 30 parts Angelica sinensis, and 30 parts Sophora flavescens. (Hereinafter referred to as "Self-Formulated Skin Moisturizing Formula No. 1") Furthermore, the preparation method of the traditional Chinese medicine composition for treating eczema includes the following steps: S1: Decoction of stir-fried Xanthium sibiricum, Phellodendron chinense, Sanguisorba officinalis, dried alum, Clematis chinensis, stir-fried Vaccaria segetalis, Artemisia argyi, Kochia scoparia, Angelica sinensis, and Sophora flavescens; S2: Cool the decocted medicine to 30-45℃ before use.

[0020] Furthermore, the specific effects of the traditional Chinese medicine composition used to treat eczema in treating eczema include: Angelica sinensis: The main chemical component of Angelica sinensis, Angelica polysaccharide, has the functions of promoting the activation of various immune cells and enhancing the secretion of cytokines. It can induce lymphocyte proliferation and upregulate the secretion of INF-γ in peripheral blood lymphocytes, suggesting that it may regulate the Th1 / Th2 balance and improve eczema lesions. Sanguisorba officinalis: The anti-inflammatory effect of Sanguisorba officinalis is mainly achieved by inhibiting the production of inflammatory mediators; and the water extract of Sanguisorba officinalis root can inhibit passive cutaneous anaphylaxis stimulated by anti-dinitrophenyl IgE and histamine release from rat peritoneal mast cells, suggesting that Sanguisorba officinalis may have the function of treating acute allergic reactions. Wang Bu Liu Xing: Wang Bu Liu Xing also has anti-inflammatory effects. It can significantly downregulate the expression levels of tumor necrosis factor-α (TNF-α) and other substances, which may play a role in inhibiting the inflammatory response of eczema. Xanthium sibiricum: Xanthium sibiricum has good anti-allergic and anti-inflammatory effects, and can inhibit antibody production and reduce the body's immune response, suggesting that it may have the effect of improving the severity of eczema lesions; Kochia scoparia fruit: The triterpenoid saponins and steroidal compounds contained in Kochia scoparia fruit have anti-inflammatory, anti-allergic, and antimicrobial pharmacological effects, and are mainly used to treat various chronic skin diseases such as itching and eczema. Sophora flavescens: The matrine and oxymatrine contained in Sophora flavescens can antagonize Th1 / Th2 drift, and treat eczema by inhibiting the secretion of inflammatory factors, effectively improving symptoms of itchy skin. Phellodendron bark: The alkaloid components of Phellodendron bark have anti-inflammatory and antibacterial pharmacological effects; Clematis armandii: Clematis armandii has anti-inflammatory effects and can also reduce capillary permeability and reduce exudation; Artemisia argyi: Artemisia argyi extract can reduce the secretion of IL-4 in serum, thereby exerting anti-inflammatory function; Alum: The trace elements in alum can enhance immunity and accelerate wound healing.

[0021] It should be noted that when using this traditional Chinese medicine composition, simply soak the affected area in the solution after it has cooled to 30-45℃. Example 2

[0022] Example 2 provides a traditional Chinese medicine composition for treating eczema, the components of which are the same as those in Example 1, the only difference being the proportions of the different components. Specifically, the weight parts of the different raw materials in Example 2 are as follows: 25 parts of stir-fried Xanthium sibiricum, 25 parts of Phellodendron chinense, 25 parts of Sanguisorba officinalis, 5 parts of dried alum, 25 parts of Clematis chinensis, 25 parts of stir-fried Vaccaria segetalis, 25 parts of Artemisia argyi, 25 parts of Kochia scoparia, 25 parts of Angelica sinensis, and 25 parts of Sophora flavescens. Example 3

[0023] Example 3 provides a traditional Chinese medicine composition for treating eczema, the components of which are the same as those in Example 1, the only difference being the proportions of the different components. Specifically, the weight parts of the different raw materials in Example 3 are as follows: 35 parts of stir-fried Xanthium sibiricum, 35 parts of Phellodendron chinense, 35 parts of Sanguisorba officinalis, 15 parts of dried alum, 35 parts of Clematis chinensis, 35 parts of stir-fried Vaccaria segetalis, 35 parts of Artemisia argyi, 35 parts of Kochia scoparia, 35 parts of Angelica sinensis, and 35 parts of Sophora flavescens. Example 4

[0024] Example 4 provides a traditional Chinese medicine composition for treating eczema, the components of which are the same as those in Example 1, the only difference being the proportions of the different components. Specifically, the weight parts of the different raw materials in Example 4 are as follows: 28 parts of stir-fried Xanthium sibiricum, 28 parts of Phellodendron chinense, 28 parts of Sanguisorba officinalis, 8 parts of dried alum, 28 parts of Clematis chinensis, 28 parts of stir-fried Vaccaria segetalis, 28 parts of Artemisia argyi, 28 parts of Kochia scoparia, 28 parts of Angelica sinensis, and 28 parts of Sophora flavescens. Example 5

[0025] Example 5 provides a traditional Chinese medicine composition for treating eczema, the components of which are the same as those in Example 1, the only difference being the proportions of the different components. Specifically, the weight parts of the different raw materials in Example 5 are as follows: 33 parts of stir-fried Xanthium sibiricum, 33 parts of Phellodendron chinense, 33 parts of Sanguisorba officinalis, 13 parts of dried alum, 33 parts of Clematis chinensis, 33 parts of stir-fried Vaccaria segetalis, 33 parts of Artemisia argyi, 33 parts of Kochia scoparia, 33 parts of Angelica sinensis, and 33 parts of Sophora flavescens.

[0026] Typical Case 1: Ms. Han, female, 38 years old, consulted on June 4, 2024, an office worker. She had experienced papules and desquamation on her hands for over 7 years. The patient reported that the papules and desquamation worsened after contact with laundry detergent and other cleaning products. The symptoms had recurred over the past 7 years; she had previously consulted at the affiliated hospital and received topical ointments, but the symptoms did not improve significantly. Now, with recurring symptoms, she consulted our department and was diagnosed with "eczema" and "spleen deficiency with dampness accumulation syndrome." She was treated with a self-prepared moisturizing formula, "Formula No. 1," applied topically once daily. After one week of treatment, the desquamation on her hands improved, and the treatment continues.

[0027] Typical Case 2: Mr. Xia, male, 54 years old, consulted on June 4, 2024, self-employed. He presented with thickened and desquamating palms for 8 months. The patient reported that 8 months prior, without any obvious cause, his palms became thickened and desquamated. He had previously treated himself with a topical "Phellodendron bark extract lotion," but the effect was unsatisfactory. One month ago, the symptoms recurred, and he consulted our department, where he was diagnosed with "eczema" and "damp-heat retention syndrome." He was prescribed a self-formulated moisturizing formula, "Formula No. 1," for external washing once daily. After 2 weeks of treatment, the desquamation on his palms subsided, and the treatment is ongoing.

[0028] Typical Case 3: Mr. Duan, male, 40 years old, consulted on June 6, 2024, a professional technician. He had presented with erythematous papules and desquamation on both hands for over a year. The patient reported that he developed erythematous papules and desquamation on both hands without any obvious cause a year ago. During that year, he self-treated with topical ointments and oral Western medicine, which provided some improvement but repeatedly worsened. Now, due to recurring symptoms, he consulted our department and was diagnosed with "eczema" and "damp-heat retention syndrome." He was prescribed a self-formulated moisturizing formula (Formula No. 1) for external washing, once daily. After one week of treatment, his symptoms improved, and the treatment continues.

[0029] Typical Case 4: Mr. Zhang, male, 53 years old, consulted on July 4, 2024. He is an office worker. He has had erythema and papules on both upper limbs and hands with itching for more than 2 years. The patient reported that erythema and papules appeared on both upper limbs without any obvious cause 2 years ago. He then sought treatment at a local private clinic and used topical ointments, but the symptoms did not improve significantly. Now the symptoms have worsened, so he consulted our department and was diagnosed with "eczema" and "spleen deficiency and blood dryness syndrome". He was prescribed a modified Guizhi Gancao Longgu Muli Tang (Cinnamon Twig, Licorice Root, Dragon Bone, and Oyster Shell Decoction) orally, combined with a self-formulated moisturizing wash once a day. After one week of treatment, the itching improved significantly, and the treatment is continuing.

[0030] Typical Case 5: Ms. Wang, 56 years old, consulted on July 18, 2024. She is an office worker. She had experienced erythematous, desquamative, and itchy patches on both hands for over 5 years. She reported that 5 years ago, without any obvious cause, she developed erythematous and itchy patches on both hands. The symptoms recurred over the past 5 years. She had previously consulted a local private clinic, receiving oral Chinese medicine and topical ointments, but the effects were unsatisfactory. Now, due to the recurrence of symptoms, she consulted our department and was diagnosed with "eczema" and "spleen deficiency with dampness accumulation syndrome." She was prescribed a modified Liuwei Dihuang Decoction orally, combined with a self-formulated skin-moisturizing formula (Formula No. 1) for external washing, once daily. After 2 weeks of treatment, the itching significantly improved, and the treatment is ongoing.

[0031] Typical Case 6: Ms. Chen, female, 29 years old, consulted on August 1, 2024, an office worker. She had been experiencing papules and fissures on her fingers for over 3 years. Initially, after using a topical cleansing product, scattered papules of varying sizes appeared on her hands, accompanied by oozing. She previously consulted the First Hospital of Hohhot, where topical ointments were used, but the effect was unsatisfactory. In the past month, the papules and fissures on her fingers worsened, prompting her to consult our department today. She was diagnosed with "eczema" and "spleen deficiency with dampness accumulation syndrome," and was prescribed a self-formulated moisturizing formula (Formula No. 1) for external washing, once daily. After two weeks of treatment, the fissures on her fingers improved, and the treatment is ongoing.

[0032] Typical Case 7: Meng, male, 12 years old, a student, visited on August 6, 2024. He had experienced recurrent cracking of his fingernails and toenails for over 3 years. The child's parents stated that 3 years ago, the child's fingernails and toenails began to crack without any obvious cause. He had previously sought treatment at the First Affiliated Hospital of Baotou Hospital, where he was treated with oral Western medicine and topical ointments, but the effects were unsatisfactory. Now, with recurring symptoms, he consulted our department and was diagnosed with "eczema" and "spleen deficiency with dampness accumulation syndrome." He was prescribed a self-formulated skin-moisturizing formula, "Formula No. 1," for external washing once daily. After 2 weeks of treatment, the symptoms improved, and the treatment is ongoing.

[0033] Typical Case 8: Mr. Yan, male, 55 years old, visited the clinic on August 8, 2024. He is an office worker. He has had cracked hands and feet with itching for more than half a year. The patient reported that six months ago, cracked hands and feet with itching appeared without any obvious cause. He did not pay attention to it and did not receive systematic treatment. Today, the itching worsened, so he visited our department and was diagnosed with "eczema" and "damp-heat retention syndrome". He was prescribed a modified "Wen Dan Tang" decoction orally, combined with a self-formulated moisturizing formula No. 1 for external washing, once a day. The itching improved after one week of treatment, and the treatment is ongoing.

[0034] Typical Case 9: Ms. Wu, female, 36 years old, consulted on August 8, 2024, an office worker. She presented with papules and vesicles on her hands and feet, accompanied by fissures and desquamation, for over a year. The patient reported that a year prior, without any obvious cause, papules and vesicles appeared on her hands and feet, accompanied by fissures and desquamation. She had previously consulted the Affiliated Hospital of Inner Mongolia Medical University, where she received oral Western medicine and topical ointments, but her symptoms did not improve significantly. She then consulted our department, where she was diagnosed with "eczema" and "spleen deficiency with dampness accumulation." She was prescribed a modified version of "Guizhi Gancao Longgu Muli Tang" (Cinnamon Twig, Licorice Root, Dragon Bone, and Oyster Shell Decoction) combined with a self-formulated skin-moisturizing wash, applied once daily. After one week of treatment, her symptoms improved, and the treatment continues.

[0035] Typical Case 10: Ms. Wei, female, 41 years old, consulted on August 20, 2024. She is a professional technician. She presented with papules and vesicles on her hands and feet, accompanied by fissures and desquamation, for over a year. The patient reported that a year ago, without any obvious cause, papules and vesicles appeared on her hands and feet, accompanied by fissures and desquamation. She had previously consulted the Affiliated Hospital of Inner Mongolia Medical University, where she received oral Western medicine and topical ointments, but her symptoms did not improve significantly. She then consulted our department, where she was diagnosed with "eczema" and "spleen deficiency with dampness accumulation." She was prescribed a modified version of "Guizhi Gancao Longgu Muli Tang" (Cinnamon Twig, Licorice Root, Dragon Bone, and Oyster Shell Decoction) combined with a self-formulated skin-moisturizing wash, applied once daily. After one week of treatment, her symptoms improved, and the treatment continues.

[0036] Typical Case 11: Ms. Cao, female, 43 years old, consulted on August 22, 2024, an office worker. She had experienced recurrent erythema and papules on both upper limbs and hands for over 3 years. The patient reported developing erythema and papules on both upper limbs 3 years prior without any obvious cause. During this period, the symptoms recurred, and she did not receive systematic treatment, instead using topical ointments on her own, with little improvement. In the past 20 days, the erythema and papules on her upper limbs and hands worsened, prompting her to consult our department. She was diagnosed with "eczema" and "blood deficiency and wind-dryness syndrome," and was prescribed a self-formulated moisturizing formula (Formula No. 1) for external washing once daily. After two weeks of treatment, the erythema and papules improved, and no new rashes appeared. The treatment is ongoing.

[0037] Typical Case 12: Ms. Guo, female, 45 years old, consulted on August 29, 2024, an office worker. She had presented with papules on both hands for over a year. The patient reported that a year ago, papules accompanied by itching appeared on both hands without any obvious cause. She sought treatment at a local hospital, receiving oral Chinese medicine and topical ointments, but the effects were unsatisfactory. She consulted our department today and was diagnosed with "eczema" and "spleen deficiency with dampness accumulation syndrome." She was prescribed a self-formulated skin-moisturizing formula, "Formula No. 1," for external washing once daily. After one week of treatment, her symptoms improved, and the treatment continues.

[0038] Typical Case 13: Yang, male, 23 years old, a student, visited the hospital on September 5, 2024.

[0039] The patient presented with papules on both palms for over a year. The patient reported developing itchy papules on both hands without any obvious cause a year ago. They sought treatment at a local hospital, receiving oral Chinese medicine and topical ointments, but the effects were unsatisfactory. They then consulted our department and were diagnosed with "eczema" and "blood deficiency and wind-dryness syndrome." A self-formulated skin-moisturizing formula (Formula No. 1) was prescribed for external washing once daily. After four weeks of treatment, the symptoms improved, and the treatment continues. The patient's hands before and after treatment are shown below. Figure 1 As shown.

[0040] Typical Case 14: Ms. Zhang, 76 years old, sought medical treatment on September 10, 2024, and is unemployed.

[0041] The patient presented with recurrent erythematous papules on both hands for over 6 years. The patient reported developing rashes on both hands 6 years ago without any apparent cause. They consulted the Air Force Medical Center in Beijing and the Affiliated Hospital of Inner Mongolia Medical University, where topical ointments provided some relief. However, the symptoms recurred, and the patient continued self-treatment with topical ointments with little effect. They recently consulted our department and were diagnosed with "eczema" and "spleen deficiency with dampness accumulation syndrome." A self-prescribed moisturizing formula (Formula No. 1) was prescribed for external washing once daily. After one week of treatment, the erythematous papules on both hands improved, and no new rashes appeared. The treatment is ongoing.

[0042] Typical Case 15: Ms. Rong, 63 years old, sought medical treatment on September 12, 2024, and is a retiree.

[0043] The patient presented with itchy papules on both feet for over 10 days. The patient reported developing rashes on both feet 10 days prior without any apparent cause. They had previously consulted a local private clinic and received topical ointment treatment, but the symptoms did not improve significantly. They then consulted our department and were diagnosed with "eczema" and "damp-heat retention syndrome." We prescribed a self-formulated moisturizing wash, "Formula No. 1," to be applied once daily. After one week of treatment, the symptoms significantly improved, and the treatment continues.

[0044] Typical Case 16: Bu, male, 21 years old, a student, visited the hospital on September 12, 2024.

[0045] The patient presented with recurrent papules on both hands for over a year. The patient reported developing rashes on both hands without any obvious cause a year ago, accompanied by cracking and itching. They had previously consulted the Affiliated Hospital of Inner Mongolia Medical University, where topical ointments were used, but the effect was unsatisfactory. They then consulted our department and were diagnosed with "eczema" and "blood deficiency and wind-dryness syndrome." A self-formulated skin-moisturizing formula, "Formula No. 1," was prescribed for external washing once daily. After four weeks of treatment, the cracking on the hands improved, and the hands became noticeably smoother.

[0046] Typical Case 17: Ms. Geng, 32 years old, sought medical treatment on September 25, 2024; she is an employee.

[0047] The patient presented with recurrent erythema, papules, scaling, and itching on both hands for over a year. The patient reported developing rashes and itching on both hands without any obvious cause a year ago. They consulted a local hospital and were treated with topical ointments, but the effect was unsatisfactory. They then consulted our department and were diagnosed with "eczema" and "blood deficiency and wind-dryness syndrome." They were prescribed a self-formulated moisturizing wash, "Formula No. 1," to be applied once daily. After one week of treatment, the itching on the hands improved, and the treatment continues.

[0048] Typical Case 18: Ms. Yun, 40 years old, sought medical treatment on October 17, 2024; she is an office worker.

[0049] The patient has experienced recurrent chapped and peeling hands for over a year. They reported recurring rashes, cracking, and peeling on their hands without any obvious cause. They had previously consulted the Affiliated Hospital of Inner Mongolia Medical University, where they received topical ointments and oral traditional Chinese medicine, but with little effect. They recently consulted our department and were diagnosed with "eczema" and "blood deficiency and wind-dryness syndrome." They were prescribed a self-formulated skin-moisturizing formula (Formula No. 1) for external washing, once daily. After one week of treatment, the cracking on their hands improved, and the treatment continues.

[0050] Typical Case 19: Ms. Zhang, 36 years old, sought medical treatment on October 10, 2024; she is an office worker.

[0051] The patient presented with recurrent thickened and cracked stratum corneum on both hands for over three years. The patient reported experiencing thickened and cracked stratum corneum on both hands for the past year without any obvious cause, and had not received any systematic treatment during this period. The patient consulted our department today and was diagnosed with "eczema" and "blood deficiency and wind-dryness syndrome." A self-prescribed moisturizing formula (Formula No. 1) was prescribed for external washing once daily. After four weeks of treatment, the cracking on both hands improved, and the treatment is ongoing. A before-and-after comparison of the patient's hands is attached. Figure 2 As shown.

[0052] Typical Case 20: Ms. Dong, 45 years old, sought medical treatment on October 17, 2024; she is an employee.

[0053] The patient presented with recurrent itchy papules on both hands for over three months. She reported that three months prior, without any obvious cause, she developed pale red papules with desquamation on both hands. She had previously consulted the Affiliated Hospital of Inner Mongolia Medical University, where topical ointments were used, but the effect was unsatisfactory. She then consulted our department and was diagnosed with "eczema" and "spleen deficiency with dampness accumulation syndrome." She was prescribed a self-formulated moisturizing wash, "Formula No. 1," applied once daily. After four weeks of treatment, the desquamation on her hands improved, and the treatment continues. A before-and-after comparison of her hands is attached. Figure 3 As shown.

[0054] Typical Case 21: Ms. Qi, 41 years old, sought medical treatment on November 5, 2024. She is a self-employed individual.

[0055] The patient presented with recurrent rashes, cracking, and itching on both hands for over a year. The patient reported developing pale red rashes on both hands without any obvious cause a year ago. After treatment with topical ointments, the skin on the hands thickened, became dry, rough, and cracked. Treatment at local hospitals was ineffective. The patient then consulted our department and was diagnosed with "eczema" and "blood deficiency and wind-dryness syndrome." A self-prescribed moisturizing formula (Formula No. 1) was prescribed for external washing once daily. After four weeks of treatment, the cracking on the hands improved. The treatment is ongoing. Before-and-after comparisons of the patient's hands are attached. Figure 4 As shown.

[0056] Typical Case 22: Pang, male, 41 years old, sought medical treatment on December 12, 2024, a retired person.

[0057] The patient presented with erythematous papules and itching on her hands and feet for over three months. She reported developing erythematous papules and fissured patches on her hands three months prior without any apparent cause. She had previously consulted the Affiliated Hospital of Inner Mongolia Medical University, where topical ointments were used with limited effectiveness. She then consulted our department and was diagnosed with "eczema" and "blood deficiency and wind-dryness syndrome." She was prescribed a self-formulated moisturizing wash, "Formula No. 1," applied once daily. After four weeks of treatment, the fissured patches on her hands improved. The treatment is ongoing. A before-and-after comparison of her hands is attached. Figure 5 As shown.

[0058] Typical Case 23: Mr. Xue, male, 35 years old, visited the hospital on November 28, 2024, and is an employee.

[0059] The patient presented with recurrent rashes, scaling, and itching on both hands for over 7 years. The patient reported developing erythematous papules on both hands 7 years ago without any obvious cause, and had previously tried topical ointments with little effect. Upon consultation with our department, the diagnosis was "eczema" and "blood deficiency and wind-dryness syndrome." A self-prescribed moisturizing formula (Formula No. 1) was prescribed for external washing once daily. After 4 weeks of treatment, the cracking on the hands improved, and the treatment continues. Before-and-after comparisons of the patient's hands are attached. Figure 6 As shown.

[0060] Typical Case 24: Ms. Sun, female, 28 years old, consulted on January 2, 2025. She is an office worker. She had presented with erythema and blisters on the back of her hands for over a year, and had previously received treatment at a local hospital using topical anti-itch ointments and steroid medications, with little effect. Her symptoms recurred, prompting her to consult our department. She was diagnosed with "eczema" and "spleen deficiency with dampness accumulation syndrome," and was treated with a self-prescribed moisturizing formula (Formula No. 1) for external washing once daily. After one week of treatment, the erythema on her hands darkened, the blisters decreased, and the itching improved. The treatment is ongoing. A comparison of the patient's hands before and after treatment is attached. Figure 7 As shown.

[0061] Typical Case 25: Ms. Wang, female, 35 years old, consulted on December 23, 2024. She is a housewife. She presented with erythema on her hands, with small blisters and itching for 6 years, which worsened after contact with cleansing agents. She had tried various treatments over the past 6 years without success. Her symptoms recurred, prompting her to consult our department. She was diagnosed with "eczema" and "spleen deficiency with dampness accumulation syndrome." She was treated with a self-prescribed moisturizing formula (Formula No. 1) for external washing once daily. After one week of treatment, the peeling on her hands improved. The treatment continues. The before-and-after comparison of her hands is attached. Figure 8 As shown.

[0062] Typical Case 26: Ms. Yang, 65 years old, consulted on December 17, 2024. She is a retired person. She had experienced rough, thickened skin on her hands accompanied by itching for four years, which worsened after contact with hand sanitizer. She had previously applied fluticasone propionate and halcinonide solution herself, with little effect. Her symptoms recurred, prompting her to consult our department. She was diagnosed with "eczema" and "spleen deficiency with dampness accumulation syndrome," and was treated with a self-prescribed moisturizing formula (Formula No. 1) for external washing once daily. After one week of treatment, her hands changed from dry to moisturized. The treatment is ongoing. The before-and-after comparison of her hands is attached. Figure 9 As shown.

[0063] Typical Case 27: Ms. Lü, female, 48 years old, consulted on December 12, 2024. She is a chef. She had suffered from erythema, oozing, and itching on her hands for 7 years, with symptoms worsening after contact with food and dishwashing liquid. Over the years, she had sought medical treatment from various doctors and used various topical washes and ointments, with no clear cause for her condition. Her symptoms recurred, prompting her to consult our department. She was diagnosed with "eczema" and "spleen deficiency with dampness accumulation syndrome," and was treated with a self-prepared moisturizing formula (Formula No. 1) for external washing once daily. After one week of treatment, the erythema on her hands darkened, and the blisters decreased. The treatment is ongoing. The before-and-after comparison of her hands is attached. Figure 10 As shown.

[0064] Typical Case 28: Ms. Feng, 58 years old, sought medical treatment on November 24, 2024. She is a retired person.

[0065] The patient presented with erythema and papules on both hands for over three years. The patient reported no obvious cause, and the symptoms recurred over the three years. Treatment included oral compound glycyrrhizin tablets and loratadine tablets, and topical fluticasone propionate cream and compound polymyxin B ointment, but with little improvement. The symptoms recurred recently, prompting the patient to consult our department. The diagnosis was "eczema" and "rheumatism affecting the skin." A self-prescribed moisturizing formula (Formula No. 1) was prescribed for external washing once daily. After one week of treatment, the erythema on both hands improved, and the treatment course was completed. A before-and-after comparison of the patient's hands is attached. Figure 11 As shown.

[0066] Typical Case 29: Wang, male, 7 years old, visited the hospital on February 18, 2024, a student.

[0067] The patient presented with erythematous and fissured skin on both feet for over a year. The patient reported no obvious cause and had previously visited the Kangbashi Mongolian Hospital for dermoscopy, where a diagnosis of "eczema" was made. Oral Mongolian medicine and traditional Chinese medicine were prescribed, with significant effects. Recently, the condition worsened, prompting the patient to seek treatment at our hospital. Appetite and sleep were normal, bowel movements were regular, but symptoms recurred. Upon consultation in our department, the diagnosis of "eczema" and "spleen deficiency with dampness accumulation" was made. A self-formulated skin-moisturizing formula (Formula No. 1) was prescribed for external washing once daily. After four weeks of treatment, the erythema on both hands improved, and the treatment continues. A before-and-after comparison of the patient's hands is attached. Figure 12 As shown.

[0068] Typical Case 30: Ms. Shi, female, 8 years old, visited the hospital on February 6, 2024, a student.

[0069] The patient presented with maculopapular rashes on both hands for over a month. The patient reported no obvious cause, sore throat, sweating, good appetite, restful sleep, and normal bowel movements. Upon consultation with our department, the diagnosis was "eczema" and "spleen deficiency with dampness accumulation syndrome." The patient was treated with a self-prepared skin-moisturizing formula (Formula No. 1) for external washing once daily. After three weeks of treatment, the erythema on both hands improved, and the treatment course was completed. A before-and-after comparison of the patient's hands is attached. Figure 13 As shown.

[0070] Typical Case 31: Ms. Gao, 27 years old, sought medical treatment on May 8, 2025. She is an employee.

[0071] The patient presented with recurring peeling and thickening of the palms of both hands for over three years. The patient reported that three years ago, the peeling began without any apparent cause, and the patient had previously treated the condition with topical ointments (specific dosage unknown), but the skin lesions did not improve significantly. The symptoms recurred, prompting the patient to consult our department. The diagnosis was "eczema" and "blood deficiency and wind-dryness syndrome." The patient was treated with a self-prescribed skin-moisturizing formula (Formula No. 1) for external washing once daily. After two weeks of treatment, the peeling on the hands improved, and the treatment continues. A before-and-after comparison of the patient's hands is attached. Figure 14 As shown.

[0072] It should be noted that in the above typical cases, some patients did not retain photos before and after treatment for comparison. Therefore, some cases did not provide comparison pictures before and after treatment, but this does not affect the evaluation and analysis of the therapeutic effect of the traditional Chinese medicine composition in this invention.

[0073] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of the present invention as claimed. The scope of protection of the present invention is defined by the appended claims and their equivalents.

Claims

1. A traditional Chinese medicine composition for treating eczema, characterized in that, The raw materials include stir-fried Xianfuzi, Huangbai, Disu, Kuanglv, Tougucao, stir-fried Wangbuluixing, Aiyi, Difuzi, Danggui, Kuanshen. The weight parts of different raw materials are as follows: stir-fried Xianfuzi 25-35 parts, Huangbai 25-35 parts, Disu 25-35 parts, Kuanglv 5-15 parts, Tougucao 25-35 parts, stir-fried Wangbuluixing 25-35 parts, Aiyi 25-35 parts, Difuzi 25-35 parts, Danggui 25-35 parts, Kuanshen 25-35 parts.

2. The traditional Chinese medicine composition for treating eczema according to claim 1, characterized in that: The weight parts of different raw materials are as follows: stir-fried Xianfuzi 30 parts, Huangbai 30 parts, Disu 30 parts, Kuanglv 10 parts, Tougucao 30 parts, stir-fried Wangbuluixing 30 parts, Aiyi 30 parts, Difuzi 30 parts, Danggui 30 parts, Kuanshen 30 parts.

3. The preparation method of the traditional Chinese medicine composition according to claim 1 or 2, characterized in that, The steps include: S1: mixing stir-fried Xianfuzi, Huangbai, Disu, Kuanglv, Tougucao, stir-fried Wangbuluixing, Aiyi, Difuzi, Danggui, Kuanshen and then decocting; S2: cooling the decocted medicinal liquid to 30-45℃ and reserving.

4. Use of the traditional Chinese medicine composition of claim 1 or 2 in the preparation of a traditional Chinese medicine preparation for treating eczema.

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