Anorectal administration device and administration method thereof

Abstract

The invention discloses an anorectal drug delivery device and a drug delivery method thereof.The anorectal drug delivery device comprises a catheter body, a near-end plugging assembly, a far-end plugging assembly, an adjusting assembly and a drug delivery tube, the catheter body is used for positioning and guiding in anorectum, and the near-end plugging assembly and the far-end plugging assembly are arranged at intervals in the axial direction of the catheter body; the near-end plugging assembly and the far-end plugging assembly are arranged on the catheter body and used for being in sealing contact with the inner wall of the anorectum and forming a closed medicine collecting cavity for containing medicine liquid, and the adjusting assembly is arranged on the catheter body, connected with the near-end plugging assembly and / or the far-end plugging assembly and used for adjusting the axial distance of the near-end plugging assembly and / or the far-end plugging assembly on the catheter body. The medicine feeding pipe is arranged on the catheter body and used for being connected with external medicine injection equipment, and at least one medicine feeding hole is formed in the section, located in the medicine collecting cavity, of the medicine feeding pipe. According to the anorectal drug delivery device, targeted aggregation and accurate delivery of liquid medicine are achieved, and the suitability and operation safety of the device are improved.

Description

Technical Field

[0001] This invention relates to the field of drug delivery devices in medical devices, and more particularly to an anorectal drug delivery device and its drug delivery method. Background Technology

[0002] Anorectal diseases are common clinical conditions, and traditional Chinese medicine often uses local drug delivery to achieve targeted treatment. Traditional drug delivery methods mainly include suppositories, ointments, sitz baths with lotions, and rectal injections. Among these, rectal injections are more widely used because the medication can be directly injected into the anus and rectum and absorbed by the mucosa, resulting in more targeted treatment.

[0003] However, existing rectal drug delivery devices require the patient to actively contract the anus to prevent medication leakage during injection. Although related technologies use an inflatable ring to expand inside the rectum and impede medication outflow, due to the length of the rectum and the fluidity of the medication, the medication still flows freely axially after entering the rectum and cannot accumulate at the lesion site. This results in a large amount of medication being far from the lesion area and not being effectively absorbed, which not only reduces the medication concentration at the lesion area but also directly affects the drug absorption efficiency and therapeutic effect. Summary of the Invention

[0004] The purpose of this invention is to provide an anorectal drug delivery device and its drug delivery method, which achieves targeted aggregation and precise delivery of the drug solution, and improves the adaptability and operational safety of the device.

[0005] The objective of this invention is achieved through the following technical solution: A rectal drug delivery device, comprising: The main body of the catheter is used for positioning and guidance within the anorectal region; The proximal occlusion assembly and the distal occlusion assembly are arranged axially and spaced apart along the main body of the catheter to form a sealed contact with the inner wall of the rectum and to form a closed drug-gathering cavity for containing the drug solution. An adjustment assembly is disposed on the catheter body and connected to the proximal occlusion assembly and / or the distal occlusion assembly respectively, for adjusting the axial spacing between the proximal occlusion assembly and / or the distal occlusion assembly on the catheter body to change the volume of the drug-collecting cavity; A drug delivery tube is disposed on the catheter body for connection to an external drug delivery device, and at least one drug delivery port is provided in the section of the drug delivery tube located in the drug-gathering cavity.

[0006] In one embodiment, the proximal and distal blocking components of the rectal delivery device are respectively expandable and contractile elastic annular bodies; and / or, The proximal occlusion assembly and the distal occlusion assembly are made of medical-grade silicone or medical-grade latex.

[0007] In one embodiment, the rectal drug delivery device further includes an inflation component, which is connected to the proximal occlusion component and the distal occlusion component respectively, for pressurizing and expanding the proximal occlusion component and the distal occlusion component.

[0008] In one embodiment, the inflation component of the rectal drug delivery device includes a manually pressurized balloon, a connecting line, and a pressure feedback unit. One end of the connecting line is connected to the proximal occlusion component and the distal occlusion component, and the other end of the connecting line is connected to the manually pressurized balloon. The pressure feedback unit is disposed on the connecting line and is used to provide feedback on the inflation pressure of the proximal occlusion component and / or the distal occlusion component.

[0009] In one embodiment, the pressure feedback unit of the rectal drug delivery device is a visible elastic indicator bladder, used to indirectly indicate the inflation pressure of the proximal occlusion assembly and the distal occlusion assembly; and / or, The inflation assembly also includes two control valves, which are used to control the proximal occlusion assembly and the distal occlusion assembly, respectively.

[0010] In one embodiment, the adjusting component of the rectal drug delivery device includes an adjusting sleeve fitted over the outside of the catheter body. The outer wall of the catheter body has a threaded portion, and the adjusting sleeve rotatably engages with the threaded portion. The adjusting sleeve is connected to a proximal occlusion component or a distal occlusion component. Rotating the adjusting sleeve drives the corresponding proximal occlusion component or distal occlusion component to move axially along the catheter body, thereby changing the distance between the proximal and distal occlusion components; and / or, The axial distance between the proximal occlusion assembly and the distal occlusion assembly is set to 2-6 cm; and / or, The volume of the drug-collecting chamber is set to 5-15 ml.

[0011] In one embodiment, the outer wall of the catheter body of the rectal drug delivery device is provided with a length scale along the axial direction, and the proximal occlusion component and / or the distal occlusion component are provided with positioning marks corresponding to the length scale.

[0012] In one embodiment, the axis of the administration port of the rectal administration device is set at an angle with the axis of the catheter body for directional spraying.

[0013] In one embodiment, the catheter body of the rectal drug delivery device is rotatably provided with a directional head, the drug delivery port is located on the directional head, and the directional head is provided with an angle indicator mark.

[0014] A method for administering medication using a rectal medication device, comprising the following steps: S1: Insert the catheter body into the anorectal region to a set depth according to the axial position of the lesion; S2: Based on the axial dimensions of the lesion, operate the adjustment component to adjust the axial spacing to match the lesion size; S3: The proximal occlusion component and the distal occlusion component expand to form a sealed contact with the anorectal wall, thereby forming the closed drug-gathering cavity in the lesion area; S4: The drug solution is injected through the drug delivery tube, and the drug solution is directed to the lesion area for targeted infiltration treatment through the drug delivery port.

[0015] Compared with the prior art, the beneficial effects of the present invention include at least the following: This application provides a rectal drug delivery device. By setting up a proximal and distal blocking component to form a closed drug-concentrating cavity, the drug solution can be confined to the lesion area, preventing it from diffusing to non-lesion sites, thereby increasing the drug concentration in the lesion area and enhancing the therapeutic effect. Furthermore, by incorporating an adjustment component, the axial distance between the proximal and distal blocking components can be flexibly adjusted, adapting to different rectal sizes and lesions with varying axial dimensions, thus having a wide range of applications. The overall structure of this rectal drug delivery device is simplified, employing a mechanical adjustment and manual inflation design, eliminating the need for complex intelligent modules, resulting in a low failure rate and low maintenance costs, making it suitable for primary healthcare institutions and traditional Chinese medicine rectal treatment scenarios.

[0016] This rectal drug delivery device, through the angled design of the drug delivery port and the rotatable directional head, can achieve directional spraying of the drug solution. The spray angle can be flexibly adjusted according to the location of the lesion, further improving the targeting of the drug delivery. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of an anorectal drug delivery device according to an embodiment of the present invention.

[0018] In the diagram: 1. Catheter body; 2. Proximal occlusion assembly; 3. Distal occlusion assembly; 4. Adjustment assembly; 5. Drug delivery tubing; 6. Inflation assembly; 51. Drug delivery port; 61. Manually pressurized balloon; 62. Connecting tubing; 63. Pressure feedback unit. Detailed Implementation

[0019] Exemplary embodiments will now be described more fully with reference to the accompanying drawings. However, these exemplary embodiments can be implemented in many forms and should not be construed as limited to the embodiments set forth herein; rather, they are provided to make the invention more comprehensive and complete, and to fully convey the concept of the exemplary embodiments to those skilled in the art. The same reference numerals in the drawings denote the same or similar structures, and therefore repeated descriptions of them will be omitted.

[0020] The terms used to express position and direction in this invention are illustrated with reference to the accompanying drawings, but changes can be made as needed, and all such changes are included within the scope of protection of this invention.

[0021] like Figure 1 As shown, an embodiment of this application provides an anorectal drug delivery device, including a catheter body 1, a proximal occlusion assembly 2, a distal occlusion assembly 3, an adjustment assembly 4, and a drug delivery tube 5.

[0022] The catheter body 1 is used for positioning and guidance within the anorectal region. The catheter body 1 is preferably made of medical-grade PVC. The outer wall of the catheter body 1 has axially spaced length graduations (not shown) with an accuracy of 1 mm, ranging from 0-15 cm, facilitating precise control of the insertion depth by medical personnel. The distal end of the catheter body 1 can be designed as a smooth, hemispherical blunt tip to avoid damage to the anorectal mucosa during insertion.

[0023] The proximal occlusion component 2 and the distal occlusion component 3 are spaced apart along the axial direction of the catheter body 1. The distal occlusion component 3 can be fixedly positioned at the distal end of the catheter body 1, 2 cm away from the blunt end, while the proximal occlusion component 2 can be movably positioned at the proximal end of the catheter body 1. Both the proximal occlusion component 2 and the distal occlusion component 3 can be expandable and contractible elastic annular bodies, preferably made of medical-grade silicone or medical-grade latex, possessing good biocompatibility and elastic recovery, adaptable to different sizes of anorectal walls, and reducing mucosal irritation. In the unexpanded state, the inner diameter of the proximal occlusion component 2 and the distal occlusion component 3 matches the outer diameter of the catheter body 1. After expansion, the outer diameter of the proximal occlusion component 2 and the distal occlusion component 3 increases, sealingly contacting the anorectal wall and forming a closed drug-collecting cavity to contain the medication.

[0024] The adjustment component 4 is mounted on the catheter body 1 and connected to the proximal occlusion component 2 and / or the distal occlusion component 3, respectively. It is used to adjust the axial distance between the proximal occlusion components 2 and / or the distal occlusion components 3 on the catheter body 1, thereby changing the volume of the drug-collecting lumen. The adjustment component 4 may include an adjustment sleeve fitted over the outside of the catheter body 1. The outer wall of the catheter body 1 has a threaded portion (not shown), located in the section of the catheter body 1 near the proximal occlusion component. The internal thread of the adjustment sleeve and the thread of the threaded portion are rotatably engaged. The distal end of the adjustment sleeve is fixed to the proximal occlusion component 2 by adhesive bonding. Rotating the adjustment sleeve causes the proximal occlusion component 2 to move axially along the catheter body 1, thereby adjusting the distance between the proximal occlusion components 2 and the distal occlusion component 3. The axial distance between the proximal occlusion components 2 and the distal occlusion component 3 is adjustable from 2 to 6 cm, corresponding to an adjustable volume of 5 to 15 ml for lesions of different sizes. The outer wall of the proximal occlusion component 2 may be provided with a red positioning mark (not shown). The red positioning mark is aligned with the length scale of the catheter body 1, which can intuitively display the current distance between the proximal occlusion component 2 and the distal occlusion component 3, making it easy to accurately control and adjust the distance.

[0025] The drug delivery tube 5 is disposed on the catheter body 1 for connection to an external drug delivery device. At least one drug delivery port 51 is provided in the section of the drug-gathering chamber of the drug delivery tube 5. The drug delivery tube 5 may be made of medical tubing and is disposed within the catheter body 1. The proximal end of the drug delivery tube 5 extends to the outside of the proximal end of the catheter body 1 and connects to a syringe. The distal end of the drug delivery tube 5 extends to the section of the catheter body 1 corresponding to the distal occlusion component 3 and the proximal occlusion component 2. The drug delivery port 51 passes through this section of the catheter body 1 to spray medication into the anorectal lesion area.

[0026] Specifically, based on the axial position of the lesion and referring to the length scale on the outer wall of the catheter body 1, the catheter body 1 is inserted into the anorectal region to the set depth, ensuring that the proximal occlusion component 2 and the distal occlusion component 3 are located on opposite sides of the lesion's axis. According to the axial dimensions of the lesion, the adjusting sleeve of the adjusting component 4 is rotated. The adjusting sleeve engages with the threaded portion of the catheter body 1, driving the proximal occlusion component 2 to move axially along the catheter body 1. Using the positioning marks, the axial distance between the two components is adjusted to match the lesion's dimensions. The proximal occlusion component 2 and the distal occlusion component 3 can be inflated using the inflation component 6. After expansion, the proximal occlusion component 2 and the distal occlusion component 3 form a tight seal with the anorectal wall, creating a closed drug-collecting cavity in the lesion area. An external drug delivery device is connected to the drug delivery tube 5, and drug solution is injected into the drug-collecting cavity through the drug delivery tube 5. The drug solution is then sprayed into the lesion area through the drug delivery port 51 and permeates the lesion.

[0027] In the aforementioned structure, the proximal blocking component 2 and the distal blocking component 3 enclose a drug-concentrating cavity, confining the drug solution to the lesion area and preventing its diffusion to non-lesion sites. This increases the drug concentration in the lesion area and enhances the therapeutic effect. Furthermore, the adjustment component 4 allows for flexible adjustment of the axial distance between the proximal blocking component 2 and the distal blocking component 3, adapting to different patients' rectal sizes and lesions with varying axial dimensions, thus broadening its applicability. This rectal drug delivery device not only improves targeted drug concentration but also enhances applicability and operational safety.

[0028] like Figure 1 As shown, in one embodiment, the rectal drug delivery device further includes an inflation assembly 6, which is connected to both the proximal occlusion assembly 2 and the distal occlusion assembly 3, for pressurizing and inflating them. The inflation assembly 6 may include a manually pressurized balloon 61, a connecting tube 62, and a pressure feedback unit 63. One end of the connecting tube 62 is connected to both the proximal occlusion assembly 2 and the distal occlusion assembly 3, and the other end is connected to the manually pressurized balloon 61. The pressure feedback unit 63 is disposed on the connecting tube 62 and is used to provide feedback on the inflation pressure of the proximal occlusion assembly 2 and / or the distal occlusion assembly 3. The pressure feedback unit 63 is preferably a visual elastic indicator balloon, used to indirectly indicate the inflation pressure of the proximal occlusion assembly 2 and the distal occlusion assembly 3. The connecting tube 62 may be a medical three-way connector. One end of the main line of the connecting pipe 62 is connected to the manually pressurized balloon 61, and the other two ends are connected to the internal inflation chambers of the proximal sealing assembly 2 and the distal sealing assembly 3 through branch lines, respectively. A visual elastic indicator bladder is installed on the main line of the connecting pipe 62. The indicator bladder is equipped with pressure scale lines of 0.05-0.2MPa. The current inflation pressure can be read intuitively by observing the degree of inflation of the indicator bladder.

[0029] Specifically, the manual pressure balloon 61 is squeezed to inflate the proximal occlusion component 2 and the distal occlusion component 3 through the connecting tube 62. At the same time, the expansion state of the elastic indicator balloon is observed, and the inflation pressure is controlled to an appropriate range so that the proximal occlusion component 2 and the distal occlusion component 3 form a tight seal with the anorectal wall after expansion, thereby forming a closed drug-collecting cavity in the lesion area.

[0030] The inflation component 6 not only enables inflation of the proximal occlusion component 2 and the distal occlusion component 3, but also allows for visual control of the inflation pressure, preventing excessive pressure from damaging the mucosa.

[0031] The inflation assembly 6 also includes two control valves, which are used to control the proximal sealing assembly 2 and the distal sealing assembly 3, respectively. The two control valves are respectively located on two branch pipes of the connecting pipe 62, and employ a shut-off valve structure to control the on / off state of the corresponding branch pipes. This enables independent inflation and deflation control of the proximal sealing assembly 2 and the distal sealing assembly 3, improving operational flexibility.

[0032] like Figure 1 As shown, in one embodiment, the axis of the drug delivery port 51 of the rectal drug delivery device is set at an angle with the axis of the catheter body 1, realizing directional spraying. Three drug delivery ports 51 can be provided at the position of the drug collection chamber on the drug delivery tube 5. The three drug delivery ports 51 are inclined, realizing directional spraying to the lesion area and further improving the targeting of drug delivery.

[0033] Furthermore, a directional head (not shown) is rotatably mounted on the catheter body 1, and the drug delivery port 51 is mounted on the directional head. An angle indicator mark is provided on the directional head, and the spray angle of the drug delivery port 51 can be adjusted by rotating the directional head.

[0034] Specifically, a directional head is rotatably mounted on the catheter body 1 at the position of the drug-gathering cavity. The directional head has a cylindrical structure and is coaxially mounted with the catheter body 1, allowing it to rotate 360 ​​degrees. The axes of the three drug-gathering holes 51 located at the distal end of the drug-gathering tube 5 on the directional head are each at a 45-degree angle to the axis of the catheter body 1, and all face inwards towards the drug-gathering cavity. An angle indicator line is provided on the outer wall of the directional head, and corresponding angle graduations are provided on the catheter body 1 to facilitate precise adjustment of the spray angle of the drug-gathering holes 51.

[0035] The included angle design of the drug delivery port 51 and the rotatable directional head enable directional spraying of the drug solution. At the same time, the spray angle can be flexibly adjusted according to the location of the lesion, further improving the targeting and applicability of drug delivery.

[0036] Embodiments of this application also provide a method for administering medication using a rectal medication device, comprising the following steps: S1: Based on the axial position of the lesion, insert the catheter body 1 into the anorectal region to the set depth. Determine the axial position of the lesion through digital rectal examination or endoscopy (e.g., 5-8 cm from the anus, axial length 3 cm). The medical staff holds the proximal end of the catheter body 1 and slowly inserts the blunt distal end into the patient's anorectal region. Referring to the length markings on the catheter body 1, the insertion depth is 8 cm, ensuring the distal sealing component 3 is positioned distal to the lesion (8 cm from the anus), and the proximal sealing component 2 is initially positioned 6 cm from the anus, ensuring the lesion is located between the two.

[0037] S2: Based on the axial dimensions of the lesion, operate the adjustment component 4 to adjust the axial spacing to match the lesion size. Based on the 3cm axial length of the lesion, rotate the adjustment sleeve of the adjustment component 4 to drive the proximal occlusion component 2 to move proximally along the catheter body 1. Observe the positioning mark on the proximal occlusion component 2. When the mark aligns with the 5cm scale line of the catheter body 1, stop rotating. At this time, the proximal occlusion component 2 is located 5cm from the anus, and the distance between it and the distal occlusion component 3 (8cm) is 3cm, which exactly matches the axial length of the lesion.

[0038] S3: The proximal occlusion component 2 and the distal occlusion component 3 expand and form a sealed contact with the anorectal wall to create the closed drug-collecting cavity in the lesion area. Securely connect the manual inflation balloon 61 of the inflation component 6 to the connecting tubing 62. First, open the control valve leading to the distal occlusion component 3, squeeze the manual inflation balloon 61 to inflate the distal occlusion component 3, and observe the visible elastic indicator balloon. When the indicated pressure reaches 0.1 MPa, close the control valve controlling the distal occlusion component 3. Then, open the control valve leading to the proximal occlusion component 2, inflate it to 0.1 MPa, and then close the control valve. At this point, both the proximal and distal occlusion components 3 expand and fit tightly against the anorectal wall, forming a closed drug-collecting cavity that completely covers the lesion area.

[0039] S4: Inject the medication through the delivery tube 5. The medication is then directed into the lesion area via the delivery port 51 for targeted infiltration treatment. Connect the syringe containing the medication to the proximal end of the delivery tube 5. Rotate the directional head and align the delivery port 51 with the core area of ​​the lesion according to the angle indicator line. Slowly push the syringe piston, and the medication is delivered through the delivery tube 5 to the delivery port 51 and sprayed directionally at a 45° angle into the lesion area. The injection volume is 8 ml (matching the current drug-collecting chamber volume corresponding to a 3 cm spacing). After injection, keep the device still for 5 minutes to allow the medication to fully infiltrate the lesion. Finally, open the two control valves to release the gas in the proximal occlusion assembly 2 and the distal occlusion assembly 3, and slowly pull out the catheter body 1 to complete the medication administration.

[0040] The above method, through four operational steps of positioning, distance adjustment, cavity formation, and drug administration, not only increases the concentration of the drug solution in the anorectal lesion area and prolongs the drug residence time, but also improves compatibility and operational safety, and reduces the operational difficulty for medical staff.

[0041] Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of the invention without departing from the principles and spirit of the invention, and all such changes should fall within the protection scope of the claims of the present invention.

Claims

1. A rectal drug delivery device, characterized in that, include: The catheter body (1) is used for positioning and guidance within the anorectal region; The proximal occlusion assembly (2) and the distal occlusion assembly (3) are arranged axially along the main body of the catheter (1) to form a sealed contact with the inner wall of the anorectal cavity and to form a closed drug-gathering cavity for containing the drug solution. Adjustment component (4), which is disposed on the catheter body (1) and connected to the proximal occlusion component (2) and / or the distal occlusion component (3) respectively, is used to adjust the axial spacing of the proximal occlusion component (2) and / or the distal occlusion component (3) on the catheter body (1) to change the volume of the drug-collecting cavity; A drug delivery tube (5) is disposed on the catheter body (1) for connection to an external drug delivery device. The drug delivery tube (5) has at least one drug delivery port (51) in the section of the drug-gathering chamber.

2. The rectal drug delivery device as described in claim 1, characterized in that, The proximal occlusion assembly (2) and the distal occlusion assembly (3) are respectively expandable and contractile elastic annular bodies; and / or, The proximal occlusion assembly (2) and the distal occlusion assembly (3) are made of medical silicone or medical latex.

3. The rectal drug delivery device as described in claim 1 or 2, characterized in that, It also includes an inflation component (6), which is connected to the proximal occlusion component (2) and the distal occlusion component (3) respectively, and is used to pressurize and expand the proximal occlusion component (2) and the distal occlusion component (3).

4. The rectal drug delivery device as described in claim 3, characterized in that, The inflation assembly (6) includes a manually pressurized balloon (61), a connecting line (62), and a pressure feedback unit (63). One end of the connecting line (62) is connected to the proximal occlusion assembly (2) and the distal occlusion assembly (3), and the other end of the connecting line (62) is connected to the manually pressurized balloon (61). The pressure feedback unit (63) is installed on the connecting line (62) and is used to provide feedback on the inflation pressure of the proximal occlusion assembly (2) and / or the distal occlusion assembly (3).

5. The rectal drug delivery device as described in claim 4, characterized in that, The pressure feedback unit (63) is a visible elastic indicator bladder used to indirectly indicate the inflation pressure of the proximal occlusion assembly (2) and the distal occlusion assembly (3); and / or, The inflation assembly (6) also includes two control valves, which are used to control the proximal occlusion assembly (2) and the distal occlusion assembly (3), respectively.

6. The rectal drug delivery device as described in claim 1, characterized in that, The adjusting component (4) includes an adjusting sleeve, which is sleeved on the outside of the catheter body (1). The outer wall of the catheter body (1) is provided with a threaded portion. The adjusting sleeve and the threaded portion are rotatably engaged. The adjusting sleeve is connected to the proximal occlusion component (2) or the distal occlusion component (3). Rotating the adjusting sleeve drives the corresponding proximal occlusion component (2) or the distal occlusion component (3) to move axially along the catheter body (1) to change the distance between the proximal occlusion component (2) and the distal occlusion component (3); and / or, The axial distance between the proximal occlusion assembly (2) and the distal occlusion assembly (3) is set to 2-6 cm; and / or, The volume of the drug-collecting chamber is set to 5-15 ml.

7. The rectal drug delivery device as described in claim 1, characterized in that, The outer wall of the catheter body (1) is provided with a length scale along the axial direction, and the proximal occlusion assembly (2) and / or the distal occlusion assembly (3) are provided with positioning marks corresponding to the length scale.

8. The rectal drug delivery device as described in claim 1, characterized in that, The axis of the drug delivery port (51) is set at an angle with the axis of the catheter body (1) for directional spraying.

9. The rectal drug delivery device as described in claim 8, characterized in that, The catheter body (1) is rotatably provided with a directional head, the administration port (51) is provided on the directional head, and the directional head is provided with an angle indicator mark.

10. A method for administering medication using a rectal medication device, comprising using the rectal medication device according to any one of claims 1-9, characterized in that, Includes the following steps: S1: According to the axial position of the lesion, insert the catheter body (1) into the anorectal region to a set depth; S2: Based on the axial dimensions of the lesion, operate the adjustment component (4) to adjust the axial spacing to match the lesion size; S3: The proximal occlusion assembly (2) and the distal occlusion assembly (3) expand to form a sealed contact with the anorectal wall to form the closed drug-gathering cavity in the lesion area; S4: The drug solution is injected through the drug delivery tube (5), and the drug solution is directed to the lesion area for targeted infiltration treatment through the drug delivery hole (51).

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