Synthetic method for preparing 4, 4 '-difluorobenzophenone through one-pot domino reaction

By using a one-pot domino reaction with 4-fluorobenzoic acid and fluorobenzene as raw materials, and reacting in a solvent-free environment under an acidic catalyst, the problems of expensive raw materials, complex processes, and environmental pollution in DFBP synthesis have been solved, achieving efficient and low-cost DFBP preparation.

CN122010702APending Publication Date: 2026-05-12JIANGSU SANJILI CHEM
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Patent Information

Application Number
CN202610024164.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-01-09
Publication Date
2026-05-12

AI Technical Summary

Technical Problem

Existing methods for synthesizing DFBP suffer from problems such as expensive raw materials, excessively long reaction routes, high energy consumption, low product selectivity, low yield and product purity, complex post-processing, and environmental pollution.

Method used

A one-pot domino reaction was used, with 4-fluorobenzoic acid and fluorobenzene as raw materials, and a solvent-free reaction was carried out under the action of an acidic catalyst. The post-processing included extraction, washing, drying and concentration to obtain 4,4'-difluorobenzophenone.

Benefits of technology

It achieves green and environmentally friendly processes, significantly reduces costs, ensures efficient and precise reactions, produces excellent product quality, and is safe and easy to operate, making it suitable for industrial production.

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Abstract

The invention relates to the technical field of preparation of fluorine-containing intermediates, and discloses a synthesis method for preparing 4, 4 '-difluorobenzophenone through a one-pot domino reaction. The invention aims to solve the problems of expensive raw materials, complex process, serious pollution, low yield and purity and the like in the prior art. According to the method, 4-fluorobenzoic acid and fluorobenzene are taken as raw materials, any one or more of trifluoromethanesulfonic anhydride, phosphorus pentoxide, trifluoroacetic anhydride or paraformaldehyde is taken as an acid catalyst under a solvent-free condition, and a target product is directly prepared through a one-pot reaction. After the reaction is finished, excessive fluorobenzene is recovered, a high-purity product is obtained through extraction, alkali washing, drying and concentration, and unreacted 4-fluorobenzoic acid can be recovered by acidifying a water phase. The method has the advantages of simple process, easily available raw materials, mild conditions and environmental protection, realizes the excellent effects that the conversion rate of 4-fluorobenzoic acid is greater than 99%, the product yield is greater than 95% and the purity is greater than 99%, and is suitable for industrial production.
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