Bimodal non-contact elasticity detection device based on Brillouin and air-blowing sweep-frequency optical coherence elastography

Abstract

The invention discloses a bimodal non-contact elasticity detection device based on Brillouin and air-blowing sweep-frequency optical coherence elastography, and relates to the technical field of imaging devices. The Brillouin-sweep-frequency optical coherence elastography common-path scanning unit focuses a Brillouin scattering signal to the surface of a biological tissue sample and focuses a sweep-frequency light beam into the biological tissue sample; the Brillouin scattering elastic imaging system collects backward Brillouin scattering light and carries out frequency discrimination processing so as to determine the longitudinal elastic modulus of the biological tissue sample; the air-blowing non-contact excitation unit is used for applying non-contact air pressure excitation to the surface of the biological tissue sample so as to generate shear wave propagation; the sweep-frequency optical coherence tomography unit is used for acquiring a backscattered light signal and carrying out interference so as to obtain phase change information caused by shear wave propagation in the biological tissue sample; and the time schedule controller is used for performing synchronous control. According to the invention, in-situ synchronous acquisition of bimodal elastic information can be realized, and the measurement consistency and reliability are improved.

Description

Technical Field

[0001] This application relates to the field of imaging device technology, and in particular to a dual-modal non-contact elasticity detection device based on Brillouin and air-blown sweep frequency optical coherent elastic imaging. Background Technology

[0002] In elastography, Brillouin scattering elastography (BSE) measures the longitudinal elastic modulus through Brillouin frequency shift, reflecting the axial stiffness of cells and the extracellular matrix. Swept-Source Optical Coherence Elastography (SS-OCE) uses a high-speed sweeping light source with a center wavelength of 1310 nm and a sweep rate of 100 kHz-400 kHz instead of a traditional broadband light source to measure shear modulus and Young's modulus. Its 1310 nm band penetrates 2-3 mm deeper into brain tissue than 850 nm, and combined with an electrodynamic optical delay line, it achieves active synchronous adjustment of the reference arm optical path, making it suitable for deep elastography. However, traditional contact excitation suffers from problems such as coupling agent contamination, interface reflection interference, and mechanical damage, making it unsuitable for fragile samples such as brain tissue.

[0003] Therefore, it is crucial to achieve simultaneous measurement of fragile samples such as brain tissue and ocular surface to obtain their biomechanical properties, while improving measurement consistency and reliability. Summary of the Invention

[0004] The purpose of this application is to provide a dual-modal non-contact elasticity detection device based on Brillouin and air-blown swept-frequency optical coherent elasticity imaging, which can realize in-situ synchronous acquisition of dual-modal elasticity information and improve measurement consistency and reliability.

[0005] To achieve the above objectives, this application provides the following solution: This application provides a dual-modal non-contact elasticity detection device based on Brillouin and air-blown sweeping optical coherent elastography, including: a Brillouin-sweeping optical coherent elastography common-path scanning unit, a Brillouin scattering elastography system, a sweeping optical coherent elastography system, and a timing controller. The Brillouin scattering elastography system and the swept-frequency optical coherence elastography system share the Brillouin-swept-frequency optical coherence elastography common-path scanning unit; the timing controller is connected to both the Brillouin scattering elastography system and the swept-frequency optical coherence elastography system. The swept-frequency optical coherence elastic imaging system includes a swept-frequency optical coherence tomography unit and an air-blown non-contact excitation unit. The Brillouin scattering elastography system is used to excite Brillouin scattering signals; The Brillouin-sweep frequency optical coherent elastography common-path scanning unit is used to focus the Brillouin scattering signal onto the surface of the biological tissue sample. The Brillouin scattering elastography system is also used to acquire backscattered Brillouin light from biological tissue samples and perform frequency discrimination processing to obtain Brillouin spectral signals in order to determine the longitudinal elastic modulus of the biological tissue samples. The swept-frequency optical coherence tomography unit is used to emit a swept-frequency beam; The Brillouin-sweep frequency optical coherence elastography common-path scanning unit is used to focus the sweep frequency beam onto the interior of the biological tissue sample; The air-blowing non-contact excitation unit is used to apply non-contact air pressure excitation to the surface of biological tissue samples to generate shear wave propagation. The swept-frequency optical coherence tomography unit is also used to acquire the backscattered light signal generated inside the biological tissue sample and to perform interference to obtain the interference signal, so as to obtain the phase change information caused by shear wave propagation inside the biological tissue sample. The timing controller is used to synchronously control the operating timing of the Brillouin scattering elastography system, the swept-frequency optical coherence tomography unit, and the air-blown non-contact excitation unit.

[0006] In one embodiment, the Brillouin scattering elastography system includes: a Brillouin signal excitation unit and a Brillouin signal acquisition unit; Both the Brillouin signal excitation unit and the Brillouin signal acquisition unit are connected to the timing controller; the Brillouin signal excitation unit and the Brillouin signal acquisition unit are connected via an optical path; the Brillouin signal excitation unit is also connected via an optical path to the Brillouin-sweep frequency optical coherent elastic imaging common-path scanning unit. The Brillouin signal excitation unit is used to excite Brillouin scattering signals; The Brillouin signal acquisition unit is used to acquire backscattered Brillouin light from biological tissue samples and perform frequency discrimination processing to obtain Brillouin spectral signals, so as to determine the longitudinal elastic modulus of biological tissue samples.

[0007] In one embodiment, the Brillouin signal excitation unit includes: a narrow linewidth continuous laser, a modulator, an optical fiber delay line, a first optical fiber circulator, a first collimator, and a beam splitter. The narrow-linewidth continuous laser is connected to the timing controller; the modulator is connected to the narrow-linewidth continuous laser; the fiber delay line is connected to the modulator; the first fiber circulator is connected to the fiber delay line; the first collimator is connected to the first fiber circulator via an optical path; the beam splitter is disposed on the output optical path of the first collimator; the beam splitter is connected to the Brillouin-sweep frequency optical coherent elastic imaging common-path scanning unit via an optical path. The narrow linewidth continuous laser is used to emit a beam; The modulator is used to modulate the light beam to obtain a modulated light beam; The fiber delay line is used to adjust the optical path of the modulated beam to obtain the modulated beam; The first port of the first fiber optic circulator is used to receive the adjustment beam, and the second port of the first fiber optic circulator is used to output the adjustment beam to the first collimator. The first collimator is used to collimate the adjustment beam and transmit the collimated beam to the beam splitter. The beam splitter is used to split the aligned beam to obtain a scattered beam; the scattered beam is used as a Brillouin scattering signal; the Brillouin scattering signal is focused onto the surface of the biological tissue sample by the Brillouin-sweep frequency optical coherence elastography common path scanning unit to generate backscattered Brillouin light through interaction. The Brillouin-sweep frequency optical coherent elastic imaging common scanning unit is also used to transmit the back Brillouin scattered light to the beam splitter. The beam splitter is also used to transmit the back-brillouin scattered light to the first collimator; The first collimator is also used to transmit the backscattered Brillouin light to port 2 of the first fiber optic circulator; port 2 of the first fiber optic circulator is used to receive the backscattered Brillouin light and transmit it to port 3 of the first fiber optic circulator. The third port of the first fiber optic circulator is used to transmit the backscattered Brillouin light to the Brillouin signal acquisition unit.

[0008] In one embodiment, the Brillouin signal acquisition unit includes: a third collimator, a Brillouin spectrometer, and a first detector; The third collimator is disposed on the outgoing optical path of port 3 of the first fiber optic circulator; the Brillouin spectrometer is connected to the third collimator; the first detector is connected to the Brillouin spectrometer; the first detector is also connected to the timing controller; The third collimator is used to collimate the backscattered Brillouin light and transmit the collimated backscattered Brillouin light to the Brillouin spectrometer. The Brillouin spectrometer is used to perform frequency discrimination processing on the backscattered Brillouin light after alignment to obtain the Brillouin spectral signal. The detector is used to receive the Brillouin spectral signal.

[0009] In one embodiment, the Brillouin-sweep frequency optical coherent elastic imaging common-path scanning unit includes: a dichroic mirror, a scanning galvanometer group, an optical shutter, and an objective lens; The dichroic mirror is disposed in the output light path of the beam splitter; the scanning galvanometer group is disposed in the output light path of the dichroic mirror; the optical shutter is disposed in the output light path of the scanning galvanometer group; the objective lens is disposed in the output light path of the optical shutter; and a biological tissue sample is disposed in the output light path of the objective lens.

[0010] In one embodiment, the swept-frequency optical coherence tomography unit includes: a swept-frequency light source, a 1×2 fiber coupler, a 2×2 fiber coupler, a sample arm optical path, a reference arm optical path, a photoelectric balance detector, and a data acquisition card. The swept-frequency light source is connected to the timing controller; the 1×2 fiber coupler is connected to the swept-frequency light source; the sample arm optical path and the reference arm optical path are both connected to the 1×2 fiber coupler; the 2×2 fiber coupler is connected to the photoelectric balance detector; the data acquisition card is connected to the photoelectric balance detector; the 2×2 fiber coupler is also connected to the sample arm optical path and the reference arm optical path respectively; the sample arm optical path is also connected to the Brillouin-swept-frequency optical coherent elastography common-path scanning unit via an optical path; The frequency sweeping light source is used to emit a frequency sweeping beam; The 1×2 fiber coupler is used to split the swept beam into a sample arm beam and a reference arm beam; The sample arm optical path is used to transmit the sample arm light to the Brillouin-sweep frequency optical coherent elastography common scanning unit; The Brillouin-sweep frequency optical coherent elastography common-path scanning unit is used to focus the sample arm light onto the interior of the biological tissue sample to generate a backscattered light signal and transmit the backscattered light signal to the sample arm optical path. The optical path of the sample arm is used to transmit the backscattered light signal to the 2×2 fiber coupler; The reference arm optical path includes an electrically driven optical delay line; the electrically driven optical delay line is used to adjust the optical path of the reference arm light to obtain the reference arm return light; The 2×2 fiber coupler is used to interfere with the backscattered light signal and the return light from the reference arm to obtain an interference signal; A photoelectric balance detector is used to receive the interference signal; The data acquisition card is used to acquire the interference signal.

[0011] In one embodiment, the sample arm optical path includes: a second fiber optic circulator and a second collimator; The second fiber circulator is connected to the 1×2 fiber coupler; the second collimator is connected to the second fiber circulator; the second collimator is also disposed on the incident light path of the Brillouin-sweep frequency optical coherent elastic imaging common path scanning unit; The first port of the second fiber optic circulator is used to receive the sample arm light; the second port of the second fiber optic circulator is used to transmit the sample arm light to the second collimator. The second collimator is used to collimate the sample arm light and transmit the collimated sample arm light to the Brillouin-sweep frequency optical coherent elastic imaging common-path scanning unit; The second collimator is also used to receive the backscattered light signal transmitted back through the Brillouin-sweep frequency optical coherent elastic imaging common path scanning unit, and to transmit the backscattered light signal to the second port of the second fiber optic circulator; The third port of the second fiber optic circulator is used to output the backscattered light signal to the 2×2 fiber optic coupler.

[0012] In one embodiment, the air-blowing non-contact excitation unit includes: a signal generator, a pressure-stabilized air tank, a two-stage precision pressure regulating valve, an air solenoid valve switch, a drive controller, and an air nozzle; The signal generator is connected to the drive controller; the drive controller is connected to the air solenoid valve switch; the pressure-stabilized gas storage tank is connected to the two-stage precision pressure regulating valve; the two-stage precision pressure regulating valve is connected to the air solenoid valve switch. The air solenoid valve switch is connected to the air nozzle; the air nozzle maintains a non-contact distance from the surface of the biological tissue sample. The signal generator is used to output pulse signals; The pressure-stabilizing gas storage tank is used to provide airflow; the two-stage precision pressure regulating valve is used to regulate the pressure of the airflow; The drive controller is used to drive and control the air solenoid valve switch to perform state change processing, so that the air nozzle outputs pulsed airflow to the surface of the biological tissue sample to generate shear wave propagation and realize non-contact air pressure excitation; the pulsed airflow is determined based on the pulse signal and the airflow.

[0013] In one embodiment, it further includes: a computer; The computer is connected to the timing controller, the Brillouin scattering elastography system, and the swept-frequency optical coherence elastography system, respectively. The computer is used to acquire the Brillouin spectral signal and the interference signal, determine the longitudinal elastic modulus of the biological tissue sample based on the Brillouin spectral signal, and acquire phase change information caused by shear wave propagation inside the biological tissue sample based on the interference signal.

[0014] According to the specific embodiments provided in this application, the following technical effects are disclosed: This application provides a dual-modal non-contact elasticity detection device based on Brillouin and air-blown swept-frequency optical coherent elastography. A Brillouin-swept-frequency optical coherent elastography common-path scanning unit focuses the Brillouin scattering signal onto the surface of the biological tissue sample and the swept-frequency beam onto the interior of the biological tissue sample. The Brillouin scattering elastography system acquires the backscattered light and performs frequency discrimination processing to determine the longitudinal elastic modulus of the biological tissue sample. An air-blown non-contact excitation unit applies non-contact air pressure excitation to the surface of the biological tissue sample to generate shear wave propagation. The swept-frequency optical coherent tomography unit acquires the backscattered light signal and performs interference to obtain the phase change information caused by shear wave propagation inside the biological tissue sample. By combining the Brillouin scattering elastography system and the swept-frequency optical coherent elastography system, dual-modal elasticity information of longitudinal elastic modulus and phase change information caused by shear wave propagation can be obtained. Furthermore, the air-blown non-contact excitation unit enables in-situ and non-contact measurement of the biological tissue sample, improving measurement reliability. In addition, this application uses a timing controller for synchronous control to improve measurement consistency. Therefore, this application can achieve in-situ synchronous acquisition of dual-modal elastic information, improving measurement consistency and reliability. Attached Figure Description

[0015] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0016] Figure 1 This is a structural diagram of a dual-modal non-contact elasticity detection device based on Brillouin and air-blown sweeping optical coherent elastic imaging.

[0017] Figure label: Narrow linewidth continuous laser-1, modulator-2, fiber delay line-3, first fiber circulator-4, first collimator-5, beam splitter-6, swept frequency source-7, 1×2 fiber coupler-8, second fiber circulator-9, second collimator-10, dichroic mirror-11, scanning galvanometer group-12, optical shutter-13, objective lens-14, motorized optical delay line-15, 2×2 fiber coupler-16, photoelectric balance detector-17, third collimator-18, Brillouin spectrometer-19, first detector-20, biological tissue sample-21, timing controller-22, computer-23, signal generator-24, drive controller-25, air solenoid valve switch-26, two-stage precision pressure regulating valve-27, pressure-stabilized gas storage tank-28. Detailed Implementation

[0018] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0019] To make the above-mentioned objectives, features and advantages of this application more apparent and understandable, the application will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0020] In one exemplary embodiment, such as Figure 1 As shown, a dual-modal non-contact elasticity detection device based on Brillouin and air-blown swept-frequency optical coherent elastography is provided. It includes: a Brillouin-swept-frequency optical coherent elastography common-path scanning unit, a Brillouin scattering elastography system, a swept-frequency optical coherent elastography system, and a timing controller 22.

[0021] The Brillouin scattering elastography system and the swept-frequency optical coherent elastography system share the Brillouin-swept-frequency optical coherent elastography common-path scanning unit; the timing controller 22 is connected to both the Brillouin scattering elastography system and the swept-frequency optical coherent elastography system.

[0022] The swept-frequency optical coherence elastography system includes a swept-frequency optical coherence tomography unit and an air-blown non-contact excitation unit.

[0023] The Brillouin scattering elastography system is used to excite the Brillouin scattering signal; the Brillouin-sweep frequency optical coherence elastography common-path scanning unit is used to focus the Brillouin scattering signal onto the surface of the biological tissue sample 21.

[0024] The Brillouin scattering elastography system is also used to acquire backscattered Brillouin light at biological tissue sample 21 and perform frequency discrimination processing to obtain Brillouin spectral signals, so as to determine the longitudinal elastic modulus of biological tissue sample 21.

[0025] The swept-frequency optical coherence tomography unit is used to emit a swept-frequency beam; the Brillouin-swept-frequency optical coherence elastography common-path scanning unit is used to focus the swept-frequency beam onto the interior of the biological tissue sample 21.

[0026] The air-blowing non-contact excitation unit is used to apply non-contact air pressure excitation to the surface of biological tissue sample 21 to generate shear wave propagation.

[0027] The swept-frequency optical coherence tomography unit is also used to acquire backscattered light signals generated inside the biological tissue sample 21 and to perform interference to obtain interference signals, so as to obtain phase change information caused by shear wave propagation inside the biological tissue sample 21.

[0028] The timing controller 22 is used to synchronously control the working timing of the Brillouin scattering elastography system, the swept-frequency optical coherence tomography unit, and the air-blown non-contact excitation unit.

[0029] The Brillouin scattering elastography system includes a Brillouin signal excitation unit and a Brillouin signal acquisition unit. Both the Brillouin signal excitation unit and the Brillouin signal acquisition unit are connected to the timing controller 22; the Brillouin signal excitation unit and the Brillouin signal acquisition unit are connected via an optical path; the Brillouin signal excitation unit is also connected via an optical path to the Brillouin-sweep frequency optical coherent elastography common-path scanning unit.

[0030] The Brillouin signal excitation unit is used to excite the Brillouin scattering signal; the Brillouin signal acquisition unit is used to acquire the backscattered Brillouin light at the biological tissue sample 21 and perform frequency discrimination processing to obtain the Brillouin spectral signal, so as to determine the longitudinal elastic modulus of the biological tissue sample 21.

[0031] The Brillouin signal excitation unit includes: a narrow linewidth continuous laser 1, a modulator 2, an optical fiber delay line 3, a first optical fiber circulator 4, a first collimator 5, and a beam splitter 6.

[0032] Narrow linewidth continuous laser 1 is connected to timing controller 22; modulator 2 is connected to narrow linewidth continuous laser 1; fiber delay line 3 is connected to modulator 2; first fiber circulator 4 is connected to fiber delay line 3; first collimator 5 is connected to first fiber circulator 4 via an optical path; beam splitter 6 is disposed on the output optical path of first collimator 5; beam splitter 6 is connected to Brillouin-sweep frequency optical coherent elastic imaging common path scanning unit via an optical path.

[0033] Narrow linewidth continuous laser 1 is used to emit a beam; modulator 2 is used to modulate the beam to obtain a modulated beam; fiber delay line 3 is used to adjust the optical path of the modulated beam to obtain an adjusted beam; port 1 of the first fiber circulator 4 is used to receive the adjusted beam, and port 2 of the first fiber circulator 4 is used to output the adjusted beam to the first collimator 5.

[0034] The first collimator 5 is used to collimate the adjustment beam and transmit the collimated beam to the beam splitter 6; the beam splitter 6 is used to split the collimated beam to obtain the scattered beam; the scattered beam is used as the Brillouin scattering signal; the Brillouin scattering signal is focused onto the surface of the biological tissue sample 21 by the Brillouin-sweep frequency optical coherence elastography common path scanning unit, so as to generate backscattered Brillouin light through interaction.

[0035] The Brillouin-sweep frequency optical coherent elastic imaging common-path scanning unit is also used to transmit the back-scattered Brillouin light to the beam splitter 6; the beam splitter 6 is also used to transmit the back-scattered Brillouin light to the first collimator 5.

[0036] The first collimator 5 is also used to transmit the back-scattered Brillouin light to port 2 of the first fiber optic circulator 4; port 2 of the first fiber optic circulator 4 is used to receive the back-scattered Brillouin light and transmit it to port 3 of the first fiber optic circulator 4.

[0037] Port 3 of the first fiber optic circulator 4 is used to transmit the backscattered Brillouin light to the Brillouin signal acquisition unit.

[0038] The Brillouin signal acquisition unit includes: a third collimator 18, a Brillouin spectrometer 19, and a first detector 20.

[0039] The third collimator 18 is set on the output optical path of port 3 of the first fiber optic circulator 4; the Brillouin spectrometer 19 is connected to the third collimator 18; the first detector 20 is connected to the Brillouin spectrometer 19; the first detector 20 is also connected to the timing controller 22.

[0040] The third collimator 18 is used to collimate the backscattered Brillouin light and transmit the collimated backscattered Brillouin light to the Brillouin spectrometer 19; the Brillouin spectrometer 19 is used to perform frequency discrimination processing on the collimated backscattered Brillouin light to obtain the Brillouin spectral signal; the detector is used to receive the Brillouin spectral signal.

[0041] The Brillouin-sweep frequency optical coherent elastography common-path scanning unit includes: a dichroic mirror 11, a scanning galvanometer group 12, an optical shutter 13, and an objective lens 14.

[0042] Dichroic mirror 11 is disposed in the output light path of beam splitter 6; scanning galvanometer group 12 is disposed in the output light path of dichroic mirror 11; optical shutter 13 is disposed in the output light path of scanning galvanometer group 12; objective lens 14 is disposed in the output light path of optical shutter 13; biological tissue sample 21 is disposed in the output light path of objective lens 14.

[0043] The swept-frequency optical coherence tomography unit includes: a swept-frequency light source 7, a 1×2 fiber coupler 8, a 2×2 fiber coupler 16, a sample arm optical path, a reference arm optical path, a photoelectric balance detector 17, and a data acquisition card.

[0044] The swept frequency light source 7 is connected to the timing controller 22; the 1×2 fiber coupler 8 is connected to the swept frequency light source 7; the sample arm optical path and the reference arm optical path are both connected to the 1×2 fiber coupler 8; the 2×2 fiber coupler 16 is connected to the photoelectric balance detector 17; the data acquisition card is connected to the photoelectric balance detector 17; the 2×2 fiber coupler 16 is also connected to the sample arm optical path and the reference arm optical path respectively; the sample arm optical path is also connected to the Brillouin-swept frequency optical coherent elastography common path scanning unit through an optical path.

[0045] The frequency sweep light source 7 is used to emit a frequency sweep beam; the center wavelength of the frequency sweep light source 7 is 1310nm, the frequency sweep bandwidth is not less than 100nm, and the frequency sweep range is 100kHz to 400kHz.

[0046] The 1×2 fiber coupler 8 is used to split the swept beam into sample arm beam and reference arm beam.

[0047] The sample arm optical path is used to transmit the sample arm light to the Brillouin-sweep frequency optical coherence elastography common path scanning unit; the Brillouin-sweep frequency optical coherence elastography common path scanning unit is used to focus the sample arm light onto the interior of the biological tissue sample 21 to generate a backscattered light signal, and transmit the backscattered light signal to the sample arm optical path.

[0048] The sample arm optical path is used to transmit the backscattered light signal to the 2×2 fiber coupler 16; the reference arm optical path includes an electric optical delay line 15; the electric optical delay line 15 is used to adjust the optical path of the reference arm light to obtain the reference arm return light.

[0049] The 2×2 fiber coupler 16 is used to interfere the backscattered light signal and the reference arm return light to obtain the interference signal; the photoelectric balance detector 17 is used to receive the interference signal; and the data acquisition card is used to acquire the interference signal.

[0050] The sample arm optical path includes: a second fiber circulator 9 and a second collimator 10; the second fiber circulator 9 is connected to a 1×2 fiber coupler 8; the second collimator 10 is connected to the second fiber circulator 9; the second collimator 10 is also disposed on the incident optical path of the Brillouin-sweep frequency optical coherent elastic imaging common path scanning unit.

[0051] The first port of the second fiber optic circulator 9 is used to receive the sample arm light; the second port of the second fiber optic circulator 9 is used to transmit the sample arm light to the second collimator 10.

[0052] The second collimator 10 is used to collimate the sample arm light and transmit the collimated sample arm light to the Brillouin-sweep frequency optical coherent elastography common path scanning unit. The second collimator 10 is also used to receive the backscattered light signal transmitted back by the Brillouin-sweep frequency optical coherent elastography common path scanning unit and transmit the backscattered light signal to port number two of the second fiber optic circulator 9.

[0053] The third port of the second fiber optic circulator 9 is used to output the backscattered light signal to the 2×2 fiber optic coupler 16.

[0054] The air-blowing non-contact excitation unit includes: a signal generator 24, a pressure-stabilized air tank 28, a two-stage precision pressure regulating valve 27, an air solenoid valve switch 26, a drive controller 25, and an air nozzle.

[0055] The signal generator 24 is connected to the drive controller 25; the drive controller 25 is connected to the air solenoid valve switch 26; the pressure-stabilized air tank 28 is connected to the two-stage precision pressure regulating valve 27; and the two-stage precision pressure regulating valve 27 is connected to the air solenoid valve switch 26.

[0056] The air solenoid valve switch 26 is connected to the air nozzle; the air nozzle maintains a non-contact distance from the surface of the biological tissue sample 21.

[0057] Signal generator 24 is used to output pulse signals; pressure-stabilized gas storage tank 28 is used to provide airflow; two-stage precision pressure regulating valve 27 is used to regulate the pressure of the airflow; drive controller 25 is used to drive and control air solenoid valve switch 26 to perform state change processing, so that the gas nozzle outputs pulsed airflow to the surface of biological tissue sample 21 to generate shear wave propagation and realize non-contact pneumatic excitation. The pulsed airflow is determined based on the pulse signal and airflow.

[0058] As an optional implementation, the dual-modal non-contact elastic detection device based on Brillouin and air-blown sweeping optical coherent elastic imaging further includes: a computer 23; the computer 23 is connected to the timing controller 22, the Brillouin scattering elastic imaging system and the sweeping optical coherent elastic imaging system respectively.

[0059] Computer 23 is used to acquire Brillouin spectral signals and interference signals, and to determine the longitudinal elastic modulus of biological tissue sample 21 based on the Brillouin spectral signals, and to acquire phase change information inside biological tissue sample 21 caused by shear wave propagation based on the interference signals.

[0060] This application mainly combines Brillouin scattering elastography and swept-frequency optical coherence elastography to detect the elastic distribution of biological soft tissues such as brain tissue.

[0061] This application innovatively adopts an air-blowing non-contact excitation unit, which generates transient air pressure pulses through a pressure-stabilized air tank 28, a two-stage precision pressure regulating valve 27, and a high-speed solenoid valve (air solenoid valve switch 26). The excitation parameters are precisely controllable, making it particularly suitable for fragile samples such as brain tissue and ocular surface.

[0062] Therefore, a multimodal elastography system combining BSE and SS-OCE is adopted, which integrates the advantages of Brillouin scattering high-precision longitudinal modulus measurement and sweep-frequency optical coherence elastography (OCE) rapid three-dimensional shear modulus / Young's modulus imaging. Through timing controller 22 and fiber delay line 3, precise synchronization of laser emission, air blowing excitation and signal acquisition is achieved. It can measure the biomechanical properties of diseased tissue in situ synchronously, that is, it can measure the longitudinal and shear elastic properties of diseased tissue in situ synchronously, providing a scientific basis for the early diagnosis of brain and neurodegenerative diseases.

[0063] The Brillouin scattering elastography system and the swept-frequency optical coherent elastography system share a common scanning unit for Brillouin-sweeped-frequency optical coherent elastography, enabling co-path transmission and synchronous scanning of dual-wavelength probe light. This application leverages the advantages of Brillouin scattering elastography for high-precision measurement of the longitudinal elastic modulus of biological tissues and swept-frequency optical coherent elastography for rapid three-dimensional imaging of the tissue shear wave propagation process. Combined with a non-contact air-blowing excitation method, it achieves in-situ, synchronous, and non-contact detection of the elastic distribution of soft tissue samples such as brain tissue, thus providing technical support for the early diagnosis and mechanistic research of neurological diseases.

[0064] The Brillouin-sweep-frequency optical coherent elastography common-path scanning unit consists of a dichroic mirror 11, a scanning galvanometer group 12, an optical shutter 13, and an objective lens 14. It is used to achieve coaxial scanning and spatially coincident focusing of probe light of different wavelengths, that is, to simultaneously acquire the Brillouin spectral signal and interference signal of the biological tissue sample 21. Specifically, the Brillouin-sweep-frequency optical coherent elastography common-path scanning unit achieves common-path propagation and excitation through the dichroic mirror 11, enabling in-situ synchronous detection by the Brillouin scattering elastography system and the sweep-frequency optical coherent elastography system. The Brillouin scattering elastography system includes a Brillouin signal excitation unit and a Brillouin signal acquisition unit. The Brillouin signal excitation unit is used to excite the Brillouin scattering signal; the Brillouin signal acquisition unit is used to acquire the Brillouin spectral signal to determine the elastic modulus. The swept-frequency optical coherence tomography system includes a swept-frequency optical coherence tomography unit and a blown-type non-contact excitation unit. The swept-frequency optical coherence tomography unit is used to collect interference signals generated inside the biological tissue sample 21 and acquire phase change information caused by shear wave propagation inside the biological tissue sample 21. The blown-type non-contact excitation unit is used to apply non-contact air pressure excitation to the surface of the biological tissue sample 21 to generate shear wave propagation. The timing controller 22 is used to synchronously control the working timing of the Brillouin scattering elastography system, the swept-frequency optical coherence tomography unit, and the blown-type non-contact excitation unit.

[0065] The Brillouin signal excitation unit consists of a narrow linewidth continuous laser 1, a modulator 2, an optical fiber delay line 3, a first optical fiber circulator 4, a first collimator 5, and a beam splitter 6. The Brillouin signal acquisition unit consists of a third collimator 18, a Brillouin spectrometer 19, and a first detector 20. The Brillouin spectrometer 19 is used to perform frequency discrimination detection on the backscattered Brillouin light. The beam emitted by the narrow linewidth continuous laser 1 enters the first port of the first fiber circulator 4 after passing through the modulator 2 and the fiber delay line 3. It is output from the second port of the first fiber circulator 4, collimated by the first collimator 5, and then split by the beam splitter 6. The transmitted beam enters the Brillouin-sweep frequency optical coherent elastic imaging common path scanning unit and is focused on the surface of the biological tissue sample 21. The backscattered Brillouin light generated by the interaction returns to the second port of the first fiber circulator 4 along the original optical path. It is output from the third port of the first fiber circulator 4 and enters the Brillouin spectrometer 19 through the third collimator 18 for frequency discrimination. It is received by the first detector 20, thereby obtaining the Brillouin spectral signal used to calculate the elastic modulus of the tissue.

[0066] The swept-frequency optical coherence tomography unit consists of a swept-frequency light source 7, a 1×2 fiber coupler 8, a 2×2 fiber coupler 16, a sample arm optical path, a reference arm optical path, a photoelectric balance detector 17, and a high-speed data acquisition card. The 1310nm swept beam emitted by the swept light source 7 enters the 1×2 fiber coupler 8 and is split into sample arm beam and reference arm beam. The sample arm beam is input through port 1 of the second fiber circulator 9, output from port 2 of the second fiber circulator 9, collimated by the second collimator 10, reflected by the dichroic mirror 11, enters the Brillouin-swept frequency optical coherence elastography common path scanning unit, and is focused onto the inside of the biological tissue sample 21. The backscattered signal light generated inside the biological tissue sample 21 returns along the original optical path to port 2 of the second fiber circulator 9, output from port 3 of the second fiber circulator 9, and is coupled to the 2×2 fiber coupler 16. The reference arm optical path includes an electro-optical delay line 15, which is used to adjust the optical path of the reference arm beam. The reference arm return beam and the sample arm return beam (i.e., the backscattered light signal) interfere in the 2×2 fiber coupler 16. The interference signal is received by the photoelectric balance detector 17, and the high-speed data acquisition card completes the signal acquisition, thereby obtaining the phase change information caused by the propagation of the shear wave under the air blowing excitation.

[0067] The motorized optical delay line 15 is composed of an optical fiber delay line 3 and a precision displacement stage. It is controlled in real time by a computer 23. When the sample arm optical path is being depth scanned, the optical path of the reference arm light is adjusted synchronously to compensate for the optical path difference of the system and ensure the stability of the interference signal contrast.

[0068] The air-blowing non-contact excitation unit consists of a signal generator 24, a pressure-stabilized gas tank 28, a two-stage precision pressure regulating valve 27, an air solenoid valve switch 26, a drive controller 25, and an air nozzle. The air nozzle maintains a non-contact distance from the surface of the biological tissue sample 21. The pressure-stabilized gas tank 28 provides a stable supply of medical air; the two-stage precision pressure regulating valve 27 enables fine-tuning of the air pressure; and the air solenoid valve switch 26 has a fast response time and can generate a transient airflow with an adjustable range.

[0069] Dichroic mirror 11 transmits light at the Brillouin wavelength and reflects light at the optically coherent elastic wavelength, enabling the co-path propagation of dual-wavelength probe light.

[0070] The dichroic mirror 11 has a transmittance of more than 90% at the Brillouin wavelength and a reflectance of more than 95% at the optical coherent elastic imaging wavelength, so as to achieve common-path propagation of probe light of different wavelengths.

[0071] The timing controller 22 is implemented using an FPGA or a high-speed microprocessor. It can programmably set the relative delay and synchronization relationship between the triggering of the frequency sweep light source 7, the light output of the narrow linewidth laser, and the data acquisition card acquisition initiated by the air blowing excitation, so as to realize the in-situ synchronous measurement of dual-modal elastic information.

[0072] The timing controller 22 is electrically connected to the swept frequency light source 7, the narrow linewidth continuous laser 1, the air-blown excitation unit, and the high-speed data acquisition card. The timing controller 22 is used to perform time-division control of the sweep frequency light source 7 triggering, Brillouin signal excitation, air-blown excitation start-up, and signal acquisition process. The optical shutter 13 is in the closed state by default after the system is powered on and initialized, and is only triggered to open when imaging begins.

[0073] This device targets biological soft tissue samples such as brain tissue. Brillouin scattering elastography provides the longitudinal elastic modulus M, which reflects the axial stiffness of cells and the extracellular matrix, while sweep-frequency optical coherence elastography provides the shear modulus μ and Young's modulus E, which reflect the tissue's shear deformation capacity. The two modal techniques complement each other to construct a complete evaluation system for elastic mechanical parameters.

[0074] This application employs swept-frequency optical coherent elastography (OCE), which, compared to spectral-domain OCE, offers greater imaging depth and higher imaging speed, making it suitable for rapid acquisition of deep elastic information from biological soft tissues. By fusing Brillouin scattering elastography and swept-frequency OCE, complementary measurements of the longitudinal elastic modulus and shear elastic parameters of the tissue are achieved, compensating for the limitations of single elastography modes in mechanical characterization. Furthermore, this application utilizes a pneumatic non-contact excitation method, avoiding the disturbance and contamination caused to soft tissue samples by traditional contact excitation. Through a common-path scanning structure and timing control, in-situ synchronous acquisition of dual-modal elastic information is achieved, improving measurement consistency and reliability.

[0075] The beams emitted by the Brillouin scattering elastography system and the swept-frequency optical coherence elastography system simultaneously reach the brain tissue sample for detection via the timing controller 22 and the fiber delay line 3, achieving in-situ synchronous measurement of the brain tissue sample with a wide field of view, high speed, and high precision.

[0076] In the swept-frequency optical coherence elastography system, the swept-frequency light source 7 emits a 1310nm swept-frequency beam. After being collimated by the 1×2 fiber coupler 8, the first port of the second fiber circulator 9, the second port of the second fiber circulator 9, and the second collimator 10, it is reflected by the dichroic mirror 11. The reflected light passes through the scanning galvanometer group 12 and the optical shutter 13, and is then focused onto the biological tissue sample 21 by the objective lens 14. The backscattered light generated by the interaction with the biological tissue sample 21 returns along the original path and enters through the second port of the second fiber circulator 9. The output signal is sent to the 2×2 fiber coupler 16, where it interferes with the beam returned from the reference arm. This interference is received by the photoelectric balance detector 17 and acquired by the data acquisition card. Simultaneously, the trigger signal generated by the sweep frequency optical coherence elastography system is synchronized by the signal generator 24, which generates a control signal. This signal is amplified by the drive controller 25 and then controlled by the air solenoid valve switch 26 to apply transient air pressure excitation to the biological tissue sample 21. This causes the biological tissue sample 21 to generate shear wave propagation, which is then acquired by the sweep frequency optical coherence tomography unit in the sweep frequency optical coherence elastography system.

[0077] The nozzle includes precision airflow nozzles of different diameters. The nozzle maintains a non-contact distance of 3mm-10mm from the surface of the biological tissue sample 21, which is used to guide the pulsed airflow to the surface of the biological tissue sample 21 to generate transient shear waves and achieve completely non-contact excitation.

[0078] The Brillouin-sweep frequency optical coherent elastography common-path scanning unit scans the biological tissue sample 21 on the XY plane through the scanning galvanometer group 12 to obtain a two-dimensional elastic distribution. At the same time, by adjusting the focal length of the objective lens 14, it scans the biological tissue sample 21 at different depths to obtain a three-dimensional Brillouin elastic distribution image.

[0079] Specifically, the testing of biological soft tissue samples such as brain tissue mainly involves eight steps: Step 1: System Initialization and Structural Imaging Preparation. Turn on the swept-frequency optical coherence elastography system. Without activating the air-blown non-contact excitation unit, the swept-frequency optical coherence elastography system can be considered as an optical coherence tomography system for acquiring tissue structure information. When the device is not performing any imaging operations, the optical shutter 13 should be closed to prevent prolonged laser irradiation of the sample from causing optical damage. At this time, block the airflow from the nozzle and open the optical shutter 13, allowing the beam scanned by the scanning galvanometer group 12 to pass through the optical shutter 13 and enter the objective lens 14.

[0080] Step 2: Tissue Structure Imaging. A swept-frequency optical coherence tomography (OCT) system is used to detect the structure of biological soft tissue. Specifically, in the swept-frequency OCT unit, a swept-frequency light beam with a center wavelength of 1310 nm emitted by the swept-frequency light source 7 is collimated by the second fiber optic circulator 9 and the second collimator 10, then reflected by the dichroic mirror 11 into the Brillouin-swept-frequency OCT common-path scanning unit, and focused by the objective lens 14 onto a biological soft tissue sample, such as brain tissue. The backscattered signal generated by the sample returns along the original optical path, enters port 2 of the second fiber optic circulator 9 through the second collimator 10, and is output from port 3 of the second fiber optic circulator 9 to the 2×2 fiber coupler 16, interfering with the return light from the reference arm. The interference signal is received by the photoelectric balance detector 17 and acquired by the data acquisition card. After processing by the computer 23, the structural information of the biological soft tissue is obtained.

[0081] Step 3: Air-blowing excitation generates shear waves. The air-blowing non-contact excitation unit is activated to apply transient non-contact air pressure excitation to the brain tissue sample, causing shear waves to propagate within the sample. Specifically, the timing controller 22 generates an external trigger signal and sends it to the signal generator 24. The signal generator 24 outputs a control waveform, which drives the air solenoid valve switch 26 to open via the drive controller 25. Simultaneously, the two-stage precision pressure regulating valve 27 precisely adjusts the air pressure output from the pressure-stabilized gas storage tank 28 to ensure the excitation intensity remains within a safe range, avoiding damage to the sample.

[0082] Step 4: Detection of shear wave propagation using swept-frequency optical coherent elastography. Under air-blown excitation, the swept-frequency optical coherent elastography system performs elastography on the brain tissue sample. Specifically, during high-speed scanning, the optical shutter 13 remains open, and the swept-frequency light source 7 continuously emits a swept-frequency beam. After being reflected by the dichroic mirror 11, the swept-frequency beam passes through the scanning galvanometer group 12 and the optical shutter 13, and is focused into the brain tissue sample by the objective lens 14. The backscattered signal generated after interacting with the sample returns along the original optical path, is output through the second fiber optic circulator 9 to the 2×2 fiber optic coupler 16, and interferes with the return light from the reference arm. The interference signal is received by the photoelectric balance detector 17 and recorded by the data acquisition card. The computer 23 performs phase analysis on the acquired signal and calculates the shear wave propagation speed.

[0083] Step 5: System mode switching. Turn off the air-blown excitation unit, stop the airflow output, turn on the Brillouin scattering elastography system, briefly close the optical shutter 13 during the switching process, and then reopen it after ensuring the optical path is stable, in preparation for Brillouin spectral signal acquisition.

[0084] Step 6: Brillouin scattering elastography single-mode detection. The Brillouin scattering elastography system detects the longitudinal elastic modulus of the brain tissue sample. Specifically, the excitation light emitted by the narrow-linewidth continuous laser 1 is adjusted in optical path by the fiber delay line 3 and then focused onto the brain tissue sample by the Brillouin-sweep frequency optical coherence elastography common-path scanning unit. The backscattered Brillouin light generated by the sample enters the Brillouin spectrometer 19 through the first fiber circulator 4, and the spectral signal is acquired by the first detector 20.

[0085] Step 7: Dual-modal synchronous excitation and detection. The air-blown excitation unit is activated to generate transient gas pressure pulses, simultaneously triggering the swept-frequency light source 7 and the narrow-linewidth continuous laser 1, ensuring that the 1310 nm swept-frequency beam and the continuous beam arrive at the brain tissue sample synchronously. The timing controller 22 precisely synchronizes the air-blown excitation, laser emission, and signal acquisition, achieving simultaneous measurement of the shear wave propagation process and the Brillouin scattering signal.

[0086] Step 8: Acquisition and Analysis of Dual-Modal Elastic Parameters. During the dual-modal synchronous detection process, the Brillouin scattering elastography system acquires the longitudinal elastic modulus M of the biological soft tissue sample with high precision; the swept-frequency optical coherence elastography system, relying on its high speed and high sensitivity, rapidly acquires the spatial distribution of the sample's shear modulus μ and Young's modulus E. The Brillouin scattering elastography system and the swept-frequency optical coherence elastography system share the Brillouin-swept-frequency optical coherence elastography common-path scanning unit to achieve in-situ synchronous detection of dual-modal elastic parameters. Specifically, the signal light generated at the brain tissue sample returns along the original optical path of the common-path scanning unit, is collected by its respective signal receiving unit, and is processed and elastic parameter inverted by computer 23.

[0087] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0088] This document uses specific examples to illustrate the principles and implementation methods of this application. The descriptions of the above embodiments are only for the purpose of helping to understand the methods and core ideas of this application. Furthermore, those skilled in the art will recognize that, based on the ideas of this application, there will be changes in the specific implementation methods and application scope. Therefore, the content of this specification should not be construed as a limitation of this application.

Claims

1. A dual-modal non-contact elasticity detection device based on Brillouin and air-blown swept-frequency optical coherent elastic imaging, characterized in that, include: Brillouin-sweep frequency optical coherent elastography common-path scanning unit, Brillouin scattering elastography system, sweep frequency optical coherent elastography system, and timing controller; The Brillouin scattering elastography system and the swept-frequency optical coherence elastography system share the Brillouin-swept-frequency optical coherence elastography common-path scanning unit; the timing controller is connected to both the Brillouin scattering elastography system and the swept-frequency optical coherence elastography system. The swept-frequency optical coherence elastic imaging system includes a swept-frequency optical coherence tomography unit and an air-blown non-contact excitation unit. The Brillouin scattering elastography system is used to excite Brillouin scattering signals; The Brillouin-sweep frequency optical coherent elastography common-path scanning unit is used to focus the Brillouin scattering signal onto the surface of the biological tissue sample. The Brillouin scattering elastography system is also used to acquire backscattered Brillouin light from biological tissue samples and perform frequency discrimination processing to obtain Brillouin spectral signals in order to determine the longitudinal elastic modulus of the biological tissue samples. The swept-frequency optical coherence tomography unit is used to emit a swept-frequency beam; The Brillouin-sweep frequency optical coherence elastography common-path scanning unit is used to focus the sweep frequency beam onto the interior of the biological tissue sample; The air-blowing non-contact excitation unit is used to apply non-contact air pressure excitation to the surface of biological tissue samples to generate shear wave propagation. The swept-frequency optical coherence tomography unit is also used to acquire the backscattered light signal generated inside the biological tissue sample and to perform interference to obtain the interference signal, so as to obtain the phase change information caused by shear wave propagation inside the biological tissue sample. The timing controller is used to synchronously control the operating timing of the Brillouin scattering elastography system, the swept-frequency optical coherence tomography unit, and the air-blown non-contact excitation unit.

2. The dual-modal non-contact elastic detection device based on Brillouin and air-blown swept-frequency optical coherent elastic imaging according to claim 1, characterized in that, The Brillouin scattering elastography system includes: a Brillouin signal excitation unit and a Brillouin signal acquisition unit; Both the Brillouin signal excitation unit and the Brillouin signal acquisition unit are connected to the timing controller; the Brillouin signal excitation unit and the Brillouin signal acquisition unit are connected via an optical path; the Brillouin signal excitation unit is also connected via an optical path to the Brillouin-sweep frequency optical coherent elastic imaging common-path scanning unit. The Brillouin signal excitation unit is used to excite Brillouin scattering signals; The Brillouin signal acquisition unit is used to acquire backscattered Brillouin light from biological tissue samples and perform frequency discrimination processing to obtain Brillouin spectral signals, so as to determine the longitudinal elastic modulus of biological tissue samples.

3. The dual-modal non-contact elastic detection device based on Brillouin and air-blown swept-frequency optical coherent elastic imaging according to claim 2, characterized in that, The Brillouin signal excitation unit includes: a narrow linewidth continuous laser, a modulator, an optical fiber delay line, a first optical fiber circulator, a first collimator, and a beam splitter. The narrow-linewidth continuous laser is connected to the timing controller; the modulator is connected to the narrow-linewidth continuous laser; the fiber delay line is connected to the modulator; the first fiber circulator is connected to the fiber delay line; the first collimator is connected to the first fiber circulator via an optical path; the beam splitter is disposed on the output optical path of the first collimator; the beam splitter is connected to the Brillouin-sweep frequency optical coherent elastic imaging common-path scanning unit via an optical path. The narrow linewidth continuous laser is used to emit a beam; The modulator is used to modulate the light beam to obtain a modulated light beam; The fiber delay line is used to adjust the optical path of the modulated beam to obtain the modulated beam; The first port of the first fiber optic circulator is used to receive the adjustment beam, and the second port of the first fiber optic circulator is used to output the adjustment beam to the first collimator. The first collimator is used to collimate the adjustment beam and transmit the collimated beam to the beam splitter. The beam splitter is used to split the aligned beam to obtain a scattered beam; the scattered beam is used as a Brillouin scattering signal; the Brillouin scattering signal is focused onto the surface of the biological tissue sample by the Brillouin-sweep frequency optical coherence elastography common path scanning unit to generate backscattered Brillouin light through interaction. The Brillouin-sweep frequency optical coherent elastic imaging common scanning unit is also used to transmit the back Brillouin scattered light to the beam splitter. The beam splitter is also used to transmit the back-brillouin scattered light to the first collimator; The first collimator is also used to transmit the backscattered Brillouin light to port 2 of the first fiber optic circulator; port 2 of the first fiber optic circulator is used to receive the backscattered Brillouin light and transmit it to port 3 of the first fiber optic circulator. The third port of the first fiber optic circulator is used to transmit the backscattered Brillouin light to the Brillouin signal acquisition unit.

4. The dual-modal non-contact elastic detection device based on Brillouin and air-blown swept-frequency optical coherent elastic imaging according to claim 3, characterized in that, The Brillouin signal acquisition unit includes: a third collimator, a Brillouin spectrometer, and a first detector; The third collimator is disposed on the outgoing optical path of port 3 of the first fiber optic circulator; the Brillouin spectrometer is connected to the third collimator; the first detector is connected to the Brillouin spectrometer; the first detector is also connected to the timing controller; The third collimator is used to collimate the backscattered Brillouin light and transmit the collimated backscattered Brillouin light to the Brillouin spectrometer. The Brillouin spectrometer is used to perform frequency discrimination processing on the backscattered Brillouin light after alignment to obtain the Brillouin spectral signal. The detector is used to receive the Brillouin spectral signal.

5. The dual-modal non-contact elastic detection device based on Brillouin and air-blown swept-frequency optical coherent elastic imaging according to claim 3, characterized in that, The Brillouin-sweep frequency optical coherent elastic imaging common-path scanning unit includes: a dichroic mirror, a scanning galvanometer group, an optical shutter, and an objective lens; The dichroic mirror is disposed in the output light path of the beam splitter; the scanning galvanometer group is disposed in the output light path of the dichroic mirror; the optical shutter is disposed in the output light path of the scanning galvanometer group; the objective lens is disposed in the output light path of the optical shutter; and a biological tissue sample is disposed in the output light path of the objective lens.

6. The dual-modal non-contact elastic detection device based on Brillouin and air-blown swept-frequency optical coherent elastic imaging according to claim 1, characterized in that, The swept-frequency optical coherence tomography unit includes: a swept-frequency light source, a 1×2 fiber coupler, a 2×2 fiber coupler, a sample arm optical path, a reference arm optical path, a photoelectric balance detector, and a data acquisition card. The swept-frequency light source is connected to the timing controller; the 1×2 fiber coupler is connected to the swept-frequency light source; the sample arm optical path and the reference arm optical path are both connected to the 1×2 fiber coupler; the 2×2 fiber coupler is connected to the photoelectric balance detector; the data acquisition card is connected to the photoelectric balance detector; the 2×2 fiber coupler is also connected to the sample arm optical path and the reference arm optical path respectively; the sample arm optical path is also connected to the Brillouin-swept-frequency optical coherent elastography common-path scanning unit via an optical path; The frequency sweeping light source is used to emit a frequency sweeping beam; The 1×2 fiber coupler is used to split the swept beam into a sample arm beam and a reference arm beam; The sample arm optical path is used to transmit the sample arm light to the Brillouin-sweep frequency optical coherent elastography common scanning unit. The Brillouin-sweep frequency optical coherent elastography common-path scanning unit is used to focus the sample arm light onto the interior of the biological tissue sample to generate a backscattered light signal and transmit the backscattered light signal to the sample arm optical path. The optical path of the sample arm is used to transmit the backscattered light signal to the 2×2 fiber coupler; The reference arm optical path includes an electrically driven optical delay line; the electrically driven optical delay line is used to adjust the optical path of the reference arm light to obtain the reference arm return light; The 2×2 fiber coupler is used to interfere with the backscattered light signal and the return light from the reference arm to obtain an interference signal; A photoelectric balance detector is used to receive the interference signal; The data acquisition card is used to acquire the interference signal.

7. The dual-modal non-contact elastic detection device based on Brillouin and air-blown swept-frequency optical coherent elastic imaging according to claim 6, characterized in that, The optical path of the sample arm includes: a second fiber optic circulator and a second collimator; The second fiber circulator is connected to the 1×2 fiber coupler; the second collimator is connected to the second fiber circulator; the second collimator is also disposed on the incident light path of the Brillouin-sweep frequency optical coherent elastic imaging common path scanning unit; The first port of the second fiber optic circulator is used to receive the sample arm light; the second port of the second fiber optic circulator is used to transmit the sample arm light to the second collimator. The second collimator is used to collimate the sample arm light and transmit the collimated sample arm light to the Brillouin-sweep frequency optical coherent elastic imaging common-path scanning unit; The second collimator is also used to receive the backscattered light signal transmitted back through the Brillouin-sweep frequency optical coherent elastic imaging common path scanning unit, and to transmit the backscattered light signal to the second port of the second fiber optic circulator; The third port of the second fiber optic circulator is used to output the backscattered light signal to the 2×2 fiber optic coupler.

8. The dual-modal non-contact elastic detection device based on Brillouin and air-blown swept-frequency optical coherent elastic imaging according to claim 1, characterized in that, The air-blowing non-contact excitation unit includes: a signal generator, a pressure-stabilized air tank, a two-stage precision pressure regulating valve, an air solenoid valve switch, a drive controller, and an air nozzle; The signal generator is connected to the drive controller; the drive controller is connected to the air solenoid valve switch; the pressure-stabilized gas storage tank is connected to the two-stage precision pressure regulating valve; the two-stage precision pressure regulating valve is connected to the air solenoid valve switch. The air solenoid valve switch is connected to the air nozzle; the air nozzle maintains a non-contact distance from the surface of the biological tissue sample. The signal generator is used to output pulse signals; The pressure-stabilizing gas storage tank is used to provide airflow; the two-stage precision pressure regulating valve is used to regulate the pressure of the airflow; The drive controller is used to drive and control the air solenoid valve switch to perform state change processing, so that the air nozzle outputs pulsed airflow to the surface of the biological tissue sample to generate shear wave propagation and realize non-contact air pressure excitation; the pulsed airflow is determined based on the pulse signal and the airflow.

9. The dual-modal non-contact elastic detection device based on Brillouin and air-blown swept-frequency optical coherent elastic imaging according to claim 1, characterized in that, Also includes: computer; The computer is connected to the timing controller, the Brillouin scattering elastography system, and the swept-frequency optical coherence elastography system, respectively. The computer is used to acquire the Brillouin spectral signal and the interference signal, determine the longitudinal elastic modulus of the biological tissue sample based on the Brillouin spectral signal, and acquire phase change information caused by shear wave propagation inside the biological tissue sample based on the interference signal.

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