Carbendazim with good degerming effect and preparation process of carbendazim

Abstract

The invention discloses carbendazim with a good degerming effect and a preparation process thereof, and relates to the technical field of pavement repair, and the technical key points are as follows: carbendazim and polyoxin are compounded, and a wetting agent, a dispersing agent, a disintegrating agent, a diluent and a binder are supplemented, so that a brand new degerming agent formula is formed; according to the scheme, an advanced airflow crushing technology and a granulation process are adopted to ensure that all components are uniformly mixed and efficiently released, so that the degerming effect of the product is greatly improved; the carbendazim-polyoxin composite water dispersible granule provided by the invention is efficient, economical and environment-friendly, the degerming effect is remarkably improved, the process requirement is not high, and the cost is relatively low.

Description

Technical Field

[0001] This invention relates to the field of road maintenance technology, and in particular to a carbendazim with good antibacterial effect and its preparation process. Background Technology

[0002] Currently, one of the most effective means of controlling plant diseases is the application of chemical agents, among which there are many types of agricultural fungicides, carbendazim being one of them. Carbendazim is a highly effective and low-toxicity systemic fungicide with significant protective and curative effects against ascomycetes and deuteromycetes. Its mechanism of action lies in interfering with the formation of the spindle apparatus during mitosis in pathogens, thereby affecting the cell division process.

[0003] Polyoxin is a highly effective, broad-spectrum, low-toxicity, and environmentally friendly biological pesticide with broad application prospects in agricultural production. Through the rational use of polyoxin, various crop diseases can be effectively controlled, crop yield and quality can be improved, and a positive contribution can be made to the sustainable development of agriculture.

[0004] Currently, carbendazim is often used alone as a suspension concentrate. While suspension concentrates, as environmentally friendly formulations, have significant advantages in reducing environmental pollution, they require stringent production process conditions, making it difficult to achieve high concentrations. Furthermore, their production, packaging, and transportation costs are relatively high, thus increasing the overall cost of use.

[0005] Furthermore, long-term, continuous, high-dose application of single chemical fungicides, including carbendazim, can easily lead to problems such as pesticide residues, environmental pollution, and the development of drug-resistant fungi. To address these issues, rational formulation or mixing of chemical fungicides has become an effective method. Through formulation or mixing, the fungicidal spectrum can be broadened, control efficacy improved, the optimal application period extended, dosage reduced, phytotoxicity decreased, residues reduced, and the occurrence and development of fungal resistance delayed. Therefore, fungicide formulation is considered one of the key means to solve the problems currently faced in the use of chemical fungicides. Summary of the Invention

[0006] In view of the above-mentioned technical problems of carbendazim having poor efficacy when used alone and high cost as a suspension agent, the present invention aims to develop a carbendazim with good antibacterial effect and its preparation process, so as to ensure the antibacterial effect and reduce the cost of the preparation process.

[0007] To achieve the above objectives, the present invention provides the following technical solution:

[0008] A carbendazim with good antibacterial effect, the formulation of which is as follows by weight percentage:

[0009] Carbendazim raw powder: 35%–75%;

[0010] Polyoxin, as a newly added active ingredient: 5%–15%;

[0011] Wetting agent: 2%–8%;

[0012] Dispersant: 3%–10%;

[0013] Disintegrant: 3%–8%;

[0014] Diluent: 5%–35%;

[0015] Adhesive: 3%–10%.

[0016] Preferably, the wetting agent is selected from one of the following: phenylethylphenol polyoxyethylene ether condensate, alkylphenol polyoxyethylene ether formaldehyde condensate, sodium alkylbenzene sulfonate, sodium alkyl sulfate, sodium alkyl phosphate, sodium phenylethylphenol polyoxyethylene ether sulfate, and sodium alkylphenol polyoxyethylene sulfate.

[0017] Preferably, the dispersant is selected from one of the following: sodium alkylnaphthalene formaldehyde condensate sulfonate, sodium alkylphenol formaldehyde condensate sulfate, sodium lignin sulfonate, sodium p-methoxy fatty amide benzene sulfonate, and sodium polycarboxylate.

[0018] Preferably, the disintegrant is selected from one of the following: bentonite, attapulgite, starch, inorganic sodium salt, fumed silica, and silica gel.

[0019] Preferably, the diluent is selected from one of the following: kaolin, light calcium carbonate, diatomaceous earth, clay, or dolomite.

[0020] Preferably, the adhesive is selected from one of the following: modified sodium polyacrylate 80, polyethylene glycol 72, modified polyvinyl alcohol 3, lignin 45, lignin 54, or modified sodium polyacrylate 50.

[0021] Formulation Analysis: Carbendazim technical powder, as the main active ingredient, has a content ranging from 35% to 75%, ensuring the product's basic antibacterial effect. The addition of polyoxin, a new active ingredient, is a highlight of this technical solution. By adding 5% to 15% polyoxin, not only can the antibacterial effect be enhanced, but the bactericidal spectrum may also be broadened, solving the problem of poor efficacy when using carbendazim alone. The addition of wetting agents and dispersants helps improve the product's dispersibility and wettability in water, thereby improving the product's effectiveness. A wide variety of preferred wetting agents and dispersants are available, allowing selection based on specific needs. The addition of disintegrants ensures rapid disintegration of the product in water, releasing the active ingredient and improving usage efficiency. Diluents are used to adjust the overall concentration of the product and may also affect its physical properties, such as flowability and bulk density. Binders play a role in tightly binding the components during the preparation process, ensuring the product's stability and durability.

[0022] A manufacturing process for a fungicide with good antibacterial effect includes the following steps:

[0023] a) Select the raw materials (excluding the binder) according to the carbendazim formula, and mix them evenly to obtain a primary mixture;

[0024] b) The primary mixture is then ultra-finely pulverized using an air jet mill to obtain master powder;

[0025] c) Mix the masterbatch with the binder according to the formula to obtain a secondary mixture;

[0026] d) The secondary mixture is granulated on a granulator to obtain granules, which are then dried.

[0027] e) After sieving the dried granules, carbendazim-polyoxin composite water-dispersible granules are obtained.

[0028] Preparation Process Analysis: First, all raw materials (except the binder) are mixed evenly. This is a crucial step to ensure uniform distribution of the product components. The mixture is then ultra-finely pulverized using an air jet mill to obtain a master powder. This step significantly improves the product's dispersibility and solubility, thereby enhancing its performance. The master powder is then mixed evenly with the binder to form a secondary mixture. The addition of the binder ensures the product's stability and durability in subsequent steps. Granulation is performed on a granulator, and the resulting granules are then dried. This step not only improves the product's physical properties but also enhances its storage stability. The dried granules are then sieved to obtain a carbendazim-polyoxin composite water-dispersible granule that meets the required specifications. Sieving ensures uniform particle size and improves the product's performance.

[0029] The present invention has the following beneficial effects:

[0030] I. Significantly improves sterilization effect

[0031] Synergistic effect of carbendazim and polyoxin: By combining carbendazim and polyoxin, a synergistic effect can be achieved, significantly improving the fungicidal effect. Carbendazim, as a broad-spectrum fungicide, can effectively control fungal diseases on various crops. Polyoxin, on the other hand, has a unique fungicidal mechanism that complements carbendazim, working together to target pathogens and enhance the fungicidal effect. The technical solution carefully designs and optimizes the proportions of carbendazim technical powder, polyoxin, and other additives to ensure that each component can fully exert its efficacy and achieve the best fungicidal effect.

[0032] II. Reduce costs and improve economic efficiency

[0033] Reduced Suspension Agent Costs: By adopting new preparation processes and formulations, this technical solution successfully reduced the cost of carbendazim as a suspension agent. This is mainly due to the optimized selection of raw materials and meticulous control of the preparation process, enabling the product to maintain highly effective sterilization while effectively controlling costs.

[0034] Improved production efficiency: The new preparation process uses modern production equipment and technologies such as airflow pulverization, granulation and drying, which improves production efficiency and reduces energy consumption and labor costs.

[0035] III. Improve product performance and enhance stability

[0036] Improved dispersibility and wettability: By adding wetting and dispersing agents, the product's dispersibility and wettability in water are improved, allowing the active ingredients to be released more quickly and act on pathogens, thus improving the effectiveness of the product.

[0037] Enhanced physical properties of the product: Granulation and drying processes are used in the preparation process to improve the physical properties of the product, such as flowability and bulk density, thereby improving the product's storage stability and ease of use.

[0038] Improved product durability: By adding a binder, the components are tightly bound together, improving the product's durability and making it less prone to breakage or deterioration during storage and use.

[0039] IV. Environmental Protection and Sustainability

[0040] Promoting resource recycling: This technical solution uses a variety of renewable resources and environmentally friendly materials in the preparation process, such as dispersants like sodium lignosulfonate. These materials not only have excellent dispersing properties, but also promote resource recycling.

[0041] In summary, this technical solution has achieved significant benefits in terms of improving sterilization effectiveness, reducing costs, enhancing product performance, and promoting environmental sustainability. These effects not only enhance the product's market competitiveness but also provide agricultural production with a more efficient, economical, and environmentally friendly disease control solution. Attached Figure Description

[0042] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present invention and should not be regarded as a limitation on the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0043] Figure 1 This is a flowchart illustrating the manufacturing process of an embodiment of the present invention. Detailed Implementation

[0044] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0045] Example 1

[0046] Weigh out 67% carbendazim technical powder (adjusting the carbendazim ratio to account for the addition of polyoxin), 10% polyoxin, 3% phenethylphenol polyoxyethylene ether formaldehyde (wetting agent), 3% sodium lignosulfonate (dispersant), 4% silica (disintegrant), and 8% light calcium carbonate (diluent). Mix these ingredients using standard methods, stir until homogeneous, and then pulverize using an air jet mill to obtain a master powder. Mix the master powder with 5% modified sodium polyacrylate 80 binder, then granulate, dry, and sieve to obtain approximately 96% 70% (carbendazim + polyoxin) composite water-dispersible granules. Testing showed that the active ingredient (carbendazim + polyoxin) content was 69.8%, moisture content ≤2.5%, pH value 7.8, sieve separation (passing through a 75μm sieve) ≥98%, suspension rate ≥65%, persistent foaming (1 min) ≤10 mL, wetting properties ≤1 min, dust ≤3.0%, and accelerated heat storage stability was qualified. In practice, when used to control apple tree ring rot, the dosage is 750–937.5 mg / kg (calculated as the total amount of carbendazim + polyoxin), and the control effect is 78–90%.

[0047] Example 2

[0048] Weigh out 68% carbendazim technical powder, 9% polyoxin, 3% sodium methylene bisbenzene sulfonate (wetting agent), 4% sodium lignosulfonate (dispersant), 5% silica (disintegrant), and 4% light calcium carbonate (diluent). Mix them evenly and then pulverize them using an air jet mill to obtain a master powder. Mix the master powder evenly with 5% polyethylene glycol 72 binder, then granulate, dry, and sieve to obtain approximately 96% 69% (carbendazim + polyoxin) composite water-dispersible granules. Testing showed an effective ingredient content of 68.5%, moisture ≤2.5%, pH 7.3, sieve separation (passing through a 75μm sieve) ≥98%, suspension rate ≥65%, persistent foaming (1min) ≤10mL, wetting ≤1min, dust ≤3.0%, and qualified accelerated heat storage stability. For the control of apple tree ring rot, the dosage is 750–937.5 mg / kg (based on the total amount of carbendazim + polyoxin), with a control efficacy of 82–94%.

[0049] Example 3

[0050] Weigh out 43% carbendazim technical powder, 10% polyoxin, 6% sodium dodecylbenzenesulfonate (wetting agent), 8% sodium lignosulfonate (dispersant), 6% attapulgite (disintegrant), and 21% kaolin (diluent). Mix them evenly and then pulverize them using an air jet mill to obtain a master powder. Mix the master powder evenly with 6% polyethylene glycol 72 binder, then granulate, dry, and sieve to obtain approximately 97% 50% (carbendazim + polyoxin) composite water-dispersible granules. Testing showed an effective ingredient content of 50.2%, moisture ≤2.5%, pH 7.3, sieve separation (passing through a 75μm sieve) ≥98%, suspension rate ≥65%, persistent foaming (1min) ≤10mL, wetting ≤1min, dust ≤3.0%, and qualified accelerated heat storage stability. For the control of apple tree ring rot, the dosage is 750–937.5 mg / kg (based on the total amount of carbendazim + polyoxin), with a control efficacy of 75–89%.

[0051] Example 4

[0052] Weigh out 44% carbendazim technical powder, 9% polyoxin, 7% sodium dodecylbenzenesulfonate (wetting agent), 9% sodium lignin sulfonate (dispersant), 6% sodium carbonate (disintegrant), and 17% diatomaceous earth (diluent). Mix them evenly and then pulverize them using an air jet mill to obtain a master powder. Mix the master powder evenly with 7% lignin 54 binder, then granulate, dry, and sieve to obtain approximately 96% 50% (carbendazim + polyoxin) composite water-dispersible granules. Testing showed an effective ingredient content of 51.1%, moisture ≤2.5%, pH 6.8, sieve separation (passing through a 75μm sieve) ≥98%, suspension rate ≥65%, persistent foaming (1min) ≤10mL, wetting ≤1min, dust ≤3.0%, and qualified accelerated heat storage stability. For the control of apple tree ring rot, the dosage is 750–937.5 mg / kg (based on the total amount of carbendazim + polyoxin), with a control efficacy of 77–93%.

[0053] Example 5

[0054] Weigh out 33% carbendazim technical powder, 9% polyoxin, 8% sodium methylene bisbenzenesulfonate (wetting agent), 9% sodium p-methyl fatty amide benzenesulfonate (dispersant), 7% sodium carbonate (disintegrant), and 24% diatomaceous earth (diluent). Mix them evenly and then pulverize them using an air jet mill to obtain a master powder. Mix the master powder evenly with 9% modified sodium polyacrylate 50 binder, then granulate, dry, and sieve to obtain approximately 95% 40% (carbendazim + polyoxin) composite water-dispersible granules. Testing showed an active ingredient content of 40.7%, moisture ≤2.5%, pH 6.9, sieve separation (passing through a 75μm sieve) ≥98%, suspension rate ≥65%, persistent foaming (1min) ≤10mL, wetting ≤1min, dust ≤3.0%, and qualified accelerated heat storage stability. For the control of apple tree ring rot, the dosage is 750–937.5 mg / kg (based on the total amount of carbendazim + polyoxin), with a control efficacy of 73–87%.

[0055] Example 6

[0056] Weigh out 32% carbendazim technical powder, 10% polyoxin, 8% sodium methylene bisnaphthalene sulfonate (wetting agent), 10% sodium p-methyl fatty amide benzene sulfonate (dispersant), 8% sodium chloride (disintegrant), and 24% diatomaceous earth (diluent). Mix them evenly and then pulverize them using an air jet mill to obtain a master powder. Mix the master powder evenly with 8% lignin 54 binder, then granulate, dry, and sieve to obtain approximately 96% 40% (carbendazim + polyoxin) composite water-dispersible granules. Testing showed that the effective ingredient content was 40.5%, moisture content ≤2.5%, pH value 7.5, sieve separation (passing through a 75μm sieve) ≥98%, suspension rate ≥65%, persistent foaming (1min) ≤10mL, wetting properties ≤1min, dust ≤3.0%, and accelerated heat storage stability was qualified. For the control of apple tree ring rot, the dosage is 750–937.5 mg / kg (based on the total amount of carbendazim + polyoxin), and the control effect is 76–91%.

[0057] like Figure 1 As shown, to enable those skilled in the art to better understand the present invention, the present invention provides a method for preparing carbendazim-polyoxin composite water-dispersible granules, comprising the following steps:

[0058] a) Raw material mixing: Select raw materials other than the binder according to the carbendazim formula, and mix them evenly to obtain a primary mixture;

[0059] b) Ultrafine grinding: The primary mixture is ultrafinely ground using an air jet mill to obtain master powder;

[0060] c) Adding binder: Mix the masterbatch with the binder according to the formula to obtain a secondary mixture;

[0061] d) Granulation and drying: The secondary mixture is granulated on a granulator to obtain granules, and then dried.

[0062] e) Screening: The dried granules are screened to obtain carbendazim-polyoxin complex water-dispersible granules.

[0063] The carbendazim-polyoxin composite water-dispersible granules processed using the formula of this invention have shown excellent dispersibility, with the active ingredient remaining suspended indefinitely; rapid disintegration (less than 3 minutes); good thermal storage stability; and high adhesion rate and long-lasting effect during use. This invention exhibits high bactericidal efficacy in production applications. Tests have proven that it achieves over 83% control of various fruit tree diseases (such as apple tree scab, ring rot, and damping-off); it also demonstrates good safety and no phytotoxicity to crops.

[0064] The above are merely specific embodiments of the present invention, but the technical features of the present invention are not limited thereto. Any simple changes, equivalent substitutions, or modifications made based on the present invention to solve essentially the same technical problems and achieve essentially the same technical effects are all covered within the protection scope of the present invention.

Claims

1. A carbendazim with good antibacterial effect, characterized in that: The carbendazim formulation, expressed as a percentage by weight, is as follows: Carbendazim raw powder: 35%–75%; Polyoxin, as a newly added active ingredient: 5%–15%; Wetting agent: 2%–8%; Dispersant: 3%–10%; Disintegrant: 3%–8%; Diluent: 5%–35%; Adhesive: 3%–10%.

2. The carbendazim with good antibacterial effect according to claim 1, characterized in that: The wetting agent is selected from one of the following: phenylethylphenol polyoxyethylene ether condensate, alkylphenol polyoxyethylene ether formaldehyde condensate, sodium alkylbenzene sulfonate, sodium alkyl sulfate, sodium alkyl phosphate, sodium phenylethylphenol polyoxyethylene ether sulfate, and sodium alkylphenol polyoxyethylene sulfate.

3. The carbendazim with good antibacterial effect according to claim 1, characterized in that: The dispersant is selected from one of the following: sodium alkylnaphthalene formaldehyde condensate sulfonate, sodium alkylphenol formaldehyde condensate sulfate, sodium lignin sulfonate, sodium p-methoxy fatty amide benzene sulfonate, and sodium polycarboxylate.

4. The carbendazim with good antibacterial effect according to claim 1, characterized in that: The disintegrant is selected from one of the following: bentonite, karatite, starch, inorganic sodium salt, silica, and silica gel.

5. The carbendazim with good antibacterial effect according to claim 1, characterized in that: The diluent may be one of the following: kaolin, light calcium carbonate, diatomaceous earth, clay, or dolomite.

6. The carbendazim with good antibacterial effect according to claim 1, characterized in that: The adhesive is selected from one of the following: modified sodium polyacrylate 80, polyethylene glycol 72, modified polyvinyl alcohol 3, lignin 45, lignin 54, or modified sodium polyacrylate 50.

7. A manufacturing process for a carbendazim with good antibacterial effect, used to produce the carbendazim with good antibacterial effect as described in any one of claims 1 to 6, characterized in that: Includes the following steps: a) Select the raw materials (excluding the binder) according to the carbendazim formula, and mix them evenly to obtain a primary mixture; b) The primary mixture is then ultra-finely pulverized using an air jet mill to obtain master powder; c) Mix the masterbatch with the binder according to the formula to obtain a secondary mixture; d) The secondary mixture is granulated on a granulator to obtain granules, which are then dried. e) After sieving the dried granules, carbendazim-polyoxin composite water-dispersible granules are obtained.

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