A fungicidal composition containing famoxadone and carvacrol

Abstract

The present application relates to a kind of fungicidal compositions containing famoxadone and carvacol, and the effective component is the binary complex of famoxadone and carvacol.The mass ratio of famoxadone and carvacol is 1-20:30-5, and the mass fraction ratio of effective component famoxadone and carvacol in preparation is 6%-50%.The dosage form of the fungicidal composition described in the present application is emulsifiable concentrate, suspension concentrate, water emulsion, microemulsion and water dispersible granule.The fungicidal composition is suitable for preventing and treating various powdery mildew, rust, leaf blight, net blotch, downy mildew, early and late blight of fruit trees, vegetables, ornamental plants, crops, etc., and has good protective and curative effects on early and late blight of tomato, etc.

Description

Technical Field

[0001] This invention relates to the field of pesticide compound technology, and in particular to a fungicide composition containing oxadiazon and carvacrol. Background Technology

[0002] Oxadiazon is a chemical substance with the molecular formula C. 22 H 18 N2O4. Oxadiazon is a broad-spectrum fungicide, mainly used to control important diseases in the Ascomycetes, Basidiomycetes, and Oomycetes classes, such as powdery mildew, rust, glume blight, net blight, downy mildew, and early / late blight. It is suitable for crops such as wheat, barley, peas, sugar beets, rapeseed, grapes, potatoes, ferns, peppers, and tomatoes.

[0003] Carvacrol is a green fungicide with the chemical formula C. 10 H 14 O can prevent gray mold in vegetables and fruit trees. It has good safety, no drug resistance, and synergistic effects with various plant-derived active ingredients. It is a plant-derived active ingredient that meets the standards for green pesticide production. Major registered crop diseases include: tomato gray mold, kiwi gray mold, wolfberry powdery mildew, and potato late blight.

[0004] Applying chemical agents is the most effective means of controlling plant diseases and pests. However, long-term, continuous, high-dose application of a single chemical fungicide can easily lead to problems such as pesticide residues, environmental pollution, and resistance. Rational compounding or mixing of chemical fungicides can broaden the fungicidal spectrum, improve control efficacy, extend the application period, reduce dosage, reduce phytotoxicity, reduce residues, and delay the development of resistance. Pesticide compounding is one of the most effective methods to solve these problems. The price of developing new fungicides is constantly rising, while the development and research of highly efficient, low-toxicity, and low-residue compounding and mixing agents has attracted attention both domestically and internationally due to its lower investment and shorter development cycle, leading to increased research and development efforts. Based on indoor screening and field trials, we have screened out a compound of oxadiazon and carvacrol, which has shown a significant synergistic effect, particularly against early and late blight in tomatoes. Early and late blight are very important diseases in crops such as tomatoes, belonging to fungal diseases, and often cause significant crop losses. This invention, based on the combination of oxadiazon and carvacrol, further enhances the efficacy by adding sodium nitrophenolate and organosilicon penetrants to repair lesions on the target and improve drug permeability. This improves drug utilization and overall efficacy. Furthermore, no previous reports have documented the combination of oxadiazon and carvacrol for fungicidal purposes and its application. Summary of the Invention

[0005] Based on the above, the purpose of this invention is to provide a novel and highly efficient pesticide fungicide composition. It is suitable for controlling leaf spot, blight, and anthracnose in fruit trees, vegetables, flowers, and other ornamental plants and crops, and is particularly effective against early and late blight.

[0006] The technical solution described in this invention is achieved through the following measures:

[0007] A bactericidal composition containing oxadiazon and carvacrol, wherein the active ingredients oxadiazon and carvacrol are a binary compound, and the remainder are auxiliary ingredients. The mass ratio of the active ingredients oxadiazon to carvacrol in the bactericidal composition is 1–20:30–5. The bactericidal composition of the present invention exhibits better synergistic effects when the mass ratio of oxadiazon to carvacrol is 3–7:12–8, and the best synergistic effect is achieved when the mass ratio is 5:10.

[0008] The bactericidal composition of the present invention can be formulated into pesticide formulations such as emulsifiable concentrates, suspension concentrates, water-in-oil emulsions, microemulsions, wettable powders, and water-dispersible granules. The total mass of the active ingredients, oxadiazon and carvacrol, in the formulation accounts for 6% to 50% of the total mass of the formulation. When they account for 10% to 25%, a good balance between toxicity and residue is achieved, and the cost is also lower.

[0009] The specific implementation scheme of the pesticide formulation prepared by the bactericidal composition of the present invention is as follows:

[0010] The bactericidal composition is an emulsifiable concentrate, and the components are in the following proportions by weight: 1-20 parts of oxadiazon; 5-30 parts of carvacrol; 8-25 parts of conventional emulsifier; 15-83 parts of conventional solvent; and 3-10 parts of conventional synergist. The specific production steps of this emulsifiable concentrate are as follows: first, the active ingredients oxadiazon and carvacrol are completely dissolved in a solvent; then, the emulsifier and synergist are added and stirred until a homogeneous, transparent oily liquid is obtained; and finally, it is filled into a container to produce the emulsifiable concentrate of the composition of this invention.

[0011] The bactericidal composition is a suspension concentrate, and the components are in the following proportions by mass: 1-20 parts of oxadiazon; 5-30 parts of carvacrol; 5-20 parts of dispersant; 1-5 parts of antifreeze; 0.1-2 parts of thickener; 0.1-0.8 parts of defoamer; 3-10 parts of synergist; 0.1-5 parts of pH adjuster; and water, with the balance being the balance. The specific production steps for this suspension concentrate are as follows: first, mix the other adjuvants, then mix them evenly using high-speed shearing; add the active ingredients oxadiazon and carvacrol; and then grind the mixture into balls in a ball mill for 2-3 hours until the particle diameter is below 5 μm, thus preparing the suspension concentrate formulation of the present invention.

[0012] The bactericidal composition is an oil-in-water emulsion, and the components are in the following proportions by mass: 1-20 parts of oxadiazon; 5-30 parts of carvacrol; 3-30 parts of emulsifier; 5-15 parts of solvent; 2-15 parts of stabilizer; 1-5 parts of antifreeze; 0.1-8 parts of defoamer; 3-10 parts of synergist; 0.2-2 parts of thickener; water, balance. The specific production steps of this oil-in-water emulsion are as follows: First, oxadiazon, carvacrol, solvent, emulsifier, and co-solvent are added together to dissolve into a homogeneous oil phase; then, a portion of water, antifreeze, antimicrobial agents, and other pesticide adjuvants are mixed together to form a homogeneous aqueous phase; while stirring at high speed in a reaction vessel, the oil phase is added to the aqueous phase, and water is slowly added until the phase inversion point is reached. A shearing machine is then turned on for high-speed shearing, and the remaining water is added. Shearing is continued for about half an hour to form an oil-in-water emulsion, thus producing the oil-in-water emulsion of the composition of this invention.

[0013] The bactericidal composition is a microemulsion, and the components are in the following proportions by mass: 1-20 parts of oxadiazon; 5-30 parts of carvacrol; 10-30 parts of emulsifier; 1-8 parts of antifreeze; 0.5-10 parts of stabilizer; 3-10 parts of synergist; and 15-30 parts of conventional solvent and co-solvent. Oxadiazon and carvacrol are completely dissolved in a co-solvent, then the emulsifier, antifreeze, stabilizer, and other components are added and mixed evenly. Finally, water is added, and the mixture is stirred thoroughly to prepare the microemulsion.

[0014] The bactericidal composition is a water-dispersible granule, and the components are in the following proportions by weight: 1-20 parts of oxadiazon; 5-30 parts of carvacrol; 5-20 parts of dispersant; 1-5 parts of wetting agent; 3-10 parts of disintegrant; 3-10 parts of adhesive; filler; water; and the balance. The components are mixed evenly according to the formula ratio, and then pulverized by air jet mill to obtain a powder. A certain amount of water is added and mixed, and the mixture is granulated in a granulator. After drying and sieving, the granular product is obtained.

[0015] The emulsifiers mentioned above are selected from any one or a mixture of one or more of the following in any proportion: calcium dodecylbenzenesulfonate, fatty acid polyoxyethylene ether, alkylphenol polyoxyethylene ether sulfosuccinate, styrylphenol polyoxyethylene ether, nonylphenol polyoxyethylene ether, castor oil polyoxyethylene ether, fatty acid polyoxyethylene ester, and polyoxyethylene fatty alcohol ether.

[0016] The solvent is a mixture of one or more of the following solvents in any proportion: xylene or toluene, methanol, ethanol, n-butanol, isopropanol, rosin-based vegetable oil (code ND-60), solvent oil, dimethylformamide, dimethyl sulfoxide, and water.

[0017] The dispersant is selected from one or more of the following: polycarboxylate with the codes YUS-WG5, TERSPERSE 2700, TERSPERSE2500; lignin sulfonate with the codes YUS-WG4, YUS-207K, WLNOK, WLNO100, TERSPERSE2020; alkylphenol polyoxyethylene ether methyl ether condensate sulfate; alkyl sulfonate calcium salt; naphthalene sulfonic acid formaldehyde condensate sodium salt; alkylphenol polyoxyethylene ether; fatty acid polyoxyethylene ester; fatty amine polyoxyethylene ether; and glycerol fatty acid ester polyoxyethylene ether.

[0018] The wetting agent is selected from one or more of the following: sodium dodecyl sulfate, calcium dodecylbenzenesulfonate, pull-opening powder BX, TERWET1004, YUS-LXC, TERSPERSE 4894, TERSPERSE2288, alkylbenzenesulfonate polyoxyethylene triphenyl phenyl phosphate, soapberry powder, silkworm excrement, and soapberry powder.

[0019] The disintegrant is selected from one or more of bentonite, urea, ammonium sulfate, aluminum chloride, citric acid, succinic acid, and sodium bicarbonate.

[0020] The binder is selected from one or more of diatomaceous earth, corn starch, PVA, carboxymethyl (ethyl) cellulose and microcrystalline cellulose.

[0021] The thickener is selected from one or more of xanthan gum, carboxymethyl cellulose, carboxyethyl cellulose, methyl cellulose, magnesium aluminum silicate, and polyvinyl alcohol.

[0022] The stabilizer is selected from one of sodium citrate, resorcinol, epoxidized soybean oil, and epichlorohydrin.

[0023] The antifreeze is selected from ethylene glycol and glycerol.

[0024] The synergist is selected from one or more of the following: code SP-4078, organosilicon, hypertonic anesthetic, wax remover, and transdermal extract.

[0025] The defoamer is selected from silicone oil, silicone compounds, and C. 10 ~C 20 Saturated fatty acid compounds, C8~C 10 One or more fatty alcohols.

[0026] The filler is selected from one or more of kaolin, diatomaceous earth, bentonite, attapulgite, silica, starch, and light calcium carbonate.

[0027] This invention provides a compound fungicide with oxadiazon and carvacrol as active ingredients, which has a significant synergistic effect, delays the development of key drug resistance, and reduces production and usage costs. It is suitable for controlling downy mildew, powdery mildew, and anthracnose in fruit trees, vegetables, flowers, and other ornamental plants and field crops, and is particularly effective against early and late blight. Detailed Implementation

[0028] To make the technical solution, objectives, and advantages of the present invention clearer, the present invention is illustrated by the following specific embodiments, but the present invention is not limited to these examples. The effects of the present invention were tested in a field trial. Unless otherwise specified, all proportions mentioned below are by weight.

[0029] Example 1: Field efficacy trial of herbicide for controlling early and late blight in tomatoes.

[0030] 15% Oxazosin·Carvacrol Microemulsion

[0031] Mix according to the following weight ratio:

[0032]

[0033]

[0034] Experiment location: Chengmai, Hainan

[0035] Control agents: 5% oxadiazon microemulsion, 10% carvacrol microemulsion, diluted with water to 30L for conventional spraying.

[0036] Table 1: Results of field efficacy trials for controlling early and late blight of tomatoes

[0037] Test reagents Dosage of the preparation Average disease index Average preventive efficacy (%) The pharmaceutical preparation in Example 1 20g / mu 9.16 92.41 5% Oxafloxacin Microemulsion 20g / mu 14.08 68.15 10% carvacrol microemulsion 20g / mu 12.29 78.32 CK - 45.32 -

[0038] As can be seen from Table 1, Example 1 of the present invention has a significantly higher control efficacy against early and late blight of tomatoes than other control agents, demonstrating excellent control effects. Specifically, using the same dosage, Example 1 achieved an average control efficacy of over 92% against early and late blight of tomatoes, while other control agents only achieved 68%-79%.

[0039] Example 2: Field efficacy trial of pesticides for controlling early and late blight in tomatoes.

[0040] 20% Oxadiazon·Carvacrol Suspension

[0041] Mix according to the following weight ratio:

[0042]

[0043] Experimental location: Chengmai, Hainan. Control agents: 5% oxadiazon suspension, 10% carvacrol suspension, diluted with water to 30L for conventional spraying.

[0044] Table 2: Field efficacy trials of pesticides for controlling early and late blight in tomatoes

[0045] Test reagents Dosage of the preparation Average disease index Average preventive efficacy (%) The pharmaceutical preparation in Example 2 20g / mu 10.35 85.69 5% Oxadiazon Suspension 20g / mu 15.36 65.01 10% carvacrol suspension 20g / mu 12.87 75.35 CK - 58.69 -

[0046] As can be seen from Table 2, Example 2 of the present invention has a significantly higher control efficacy against early and late blight of tomatoes than other control agents, demonstrating excellent control effects. Specifically, using the same dosage, Example 2 achieved an average control efficacy of over 85% against early and late blight of tomatoes, while other control agents only achieved 65%-76%.

[0047] Example 3: Field efficacy trial of pesticides for controlling early and late blight in peppers.

[0048] 15% Oxazosin·Carvacrol EC

[0049] Mix according to the following weight ratio:

[0050]

[0051] Experiment location: Chengmai, Hainan

[0052] Control agents: 5% oxadiazon EC and 10% carvacrol EC, diluted with water to 30L for conventional spraying.

[0053] Table 3: Results of field efficacy trials for controlling early and late blight in chili peppers

[0054]

[0055]

[0056] As can be seen from Table 3, Example 3 of the present invention has a significantly higher control efficacy against early and late blight of peppers than other control agents, demonstrating excellent control effects. Specifically, using the same dosage, Example 3 achieved an average control efficacy of over 88% against early and late blight of peppers, while other control agents only achieved 64%-74%.

[0057] Results analysis:

[0058] In summary, the fungicidal composition of this invention containing oxadiazon and carvacrol, specifically a 15% oxadiazon·carvacrol microemulsion, exhibits excellent control efficacy against early and late blight of tomatoes, and is safe for the target crop. This compound formulation not only improves efficacy but also broadens the fungicidal spectrum, expands its application range, reduces costs, and provides dual control of multiple diseases with a single agent, reducing manpower and material resources and improving production efficiency. Therefore, the invention and promotion of this compound formulation are of great social significance.

[0059] The above description, in conjunction with specific embodiments, provides a further detailed explanation of the present invention, but it should not be construed as limiting the specific implementation of the invention to these descriptions. For those skilled in the art, several simple deductions or substitutions can be made without departing from the concept of the present invention.

Claims

1. A bactericidal composition containing oxadiazon and carvacrol, characterized in that: The active ingredient of this bactericidal composition is a binary compound of oxadiazon and carvacrol, with the remainder being auxiliary ingredients. The mass ratio of the active ingredient oxadiazon to carvacrol is 1-20:30-5.

2. The bactericidal composition according to claim 1, characterized in that: The total weight of oxadiazon and carvacrol in the formulation accounts for 6% to 50% of the total weight of the formulation.

3. The bactericidal composition according to claim 1 or 2, characterized in that: The bactericidal composition is available in the form of emulsifiable concentrate, suspension concentrate, water emulsion, microemulsion, or water-dispersible granules.

4. The bactericidal composition according to claim 1 or 2, characterized in that: This bactericidal composition has a good protective and therapeutic effect against late blight in tomatoes.

5. The bactericidal composition according to claim 1 or 2, characterized in that: The bactericidal effect is optimal when the ratio of oxadiazon to carvacrol in the bactericidal composition is 5:10.

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